Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
Published 10 Jan 2013 · application patented
Current assignee: Chugai Pharmaceutical Co., Ltd. (Roche) · originally Roche
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Inventors: Shinya Ishii, Atsuhiko Maeda, Takashi Nakai, Tomoyuki Igawa · Examiner: James Rogers
Life of the application
12 dated eventsAbstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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8 codes- A61K39/00
- A61K39/395
- C07K16/00
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