Human semaphorin homologs and polynucleotides encoding the same

The present application claims the benefit of U.S. Provisional Application Nos. 60/205,274 and 60/208,893 which were filed on May 18, 2000 and Jun. 2, 2000, respectively. These U.S. Provisional Applications are herein incorporated by reference in their entirety.

1. INTRODUCTION

The present invention relates to the discovery, identification, and characterization of novel human polynucleotides encoding a protein that shares sequence similarity with mammalian semaphorin proteins. The invention encompasses the described polynucleotides, host cell expression systems, the encoded proteins, fusion proteins, polypeptides and peptides, antibodies to the encoded proteins and peptides, and genetically engineered animals that either lack or over express the disclosed polynucleotides, antagonists and agonists of the proteins, and other compounds that modulate the expression or activity of the proteins encoded by the disclosed polynucleotides that can be used for diagnosis, drug screening, clinical trial monitoring, the treatment of physiological disorders or diseases, and cosmetic or nutriceutical applications.

2. BACKGROUND OF THE INVENTION

Semaphorins are members of a superfamily of structurally related proteins that have been associated with axon guidance. Their expression in non-neural tissues indicate that semaphorins can regulate biology in ways beyond axon guidance.

3. SUMMARY OF THE INVENTION

The present invention relates to the discovery, identification, and characterization of nucleotides that encode novel human proteins, and the corresponding amino acid sequences of these proteins. The novel human protein (NHP) described for the first time herein share structural similarity with mammalian semaphorins and particularly semaphorin G (SEQ ID NOS: 1-17) and semaphorin G (subclass 4) (SEQ ID NOS: 18-50).

The novel human nucleic acid sequences described herein, encode alternative proteins/open reading frames (ORFs) of 1049, 1093, 1034, 1078, 1151, 1136, 954, 939, 215, 496, 702, 697, 843, 838, 870, 865, 116, 397, 603, 598, 744, 739, 771, and 766 amino acids in length (see respectively SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, and 49).

The invention also encompasses agonists and antagonists of the described NHPs, including small molecules, large molecules, mutant NHPs, or portions thereof, that compete with native NHP, peptides, and antibodies, as well as nucleotide sequences that can be used to inhibit the expression of the described NHPs (e.g., antisense and ribozyme molecules, and gene or regulatory sequence replacement constructs) or to enhance the expression of the described NHP polynucleotides (e.g., expression constructs that place the described polynucleotide under the control of a strong promoter system), and transgenic animals that express a NHP transgene, or “knock-outs” (which can be conditional) that do not express a functional NHP. Knock-out mice can be produced in several ways, one of which involves the use of mouse embryonic stem cells (“ES cells”) lines that contain gene trap mutations in a murine homolog of at least one of the described NHPs. When the unique NHP sequences described in SEQ ID NOS:1-50 are “knocked-out” they provide a method of identifying phenotypic expression of the particular gene as well as a method of assigning function to previously unknown genes. To this end, several gene trapped knockout ES cells have been generated in murine homologs of the described NHPs. Additionally, the unique NHP sequences described in SEQ ID NOS:1-50 are useful for the identification of coding sequence and the mapping a unique gene to a particular chromosome.

Further, the present invention also relates to processes for identifying compounds that modulate, i.e., act as agonists or antagonists, of NHP expression and/or NHP activity that utilize purified preparations of the described NHPs and/or NHP product, or cells expressing the same. Such compounds can be used as therapeutic agents for the treatment of any of a wide variety of symptoms associated with biological disorders or imbalances.

4. DESCRIPTION OF THE SEQUENCE LISTING AND FIGURES

The Sequence Listing provides the sequences of the described NHP ORFs that encode the described NHP amino acid sequences. SEQ ID NO:17 and SEQ ID NO:50 describe full length NHP ORFs and flanking sequences.

5. DETAILED DESCRIPTION OF THE INVENTION

The NHP, described for the first time herein, are novel proteins that are widely expressed. SEQ ID NO:1-17 are novel NHPs expressed in, inter alia, human cell lines, and human brain, pituitary, cerebellum, kidney, prostate, testis, thyroid, adrenal gland, pancreas, salivary gland, heart, uterus, cervix, pericardium, fetal kidney and fetal lung cells. SEQ ID NO:18-50 describe for the first time herein, are novel proteins that are expressed in, inter alia, human cell lines, human brain, fetal brain, lymph node, mammary gland, pituitary gland, placenta, prostate, kidney, thyroid, and umbilical vein endothelial cells.

The present invention encompasses the nucleotides presented in the Sequence Listing, host cells expressing such nucleotides, the expression products of such nucleotides, and: (a) nucleotides that encode mammalian homologs of the described polynucleotides, including the specifically described NHPs, and the NHP products; (b) nucleotides that encode one or more portions of the NHPs that correspond to functional domains, and the polypeptide products specified by such nucleotide sequences, including but not limited to the novel regions of any active domain(s); (c) isolated nucleotides that encode mutant versions, engineered or naturally occurring, of the described NHPs in which all or a part of at least one domain is deleted or altered, and the polypeptide products specified by such nucleotide sequences, including but not limited to soluble proteins and peptides in which all or a portion of the signal (or hydrophobic transmembrane) sequence is deleted; (d) nucleotides that encode chimeric fusion proteins containing all or a portion of a coding region of an NHP, or one of its domains (e.g., a receptor or ligand binding domain, accessory protein/self-association domain, etc.) fused to another peptide or polypeptide; or (e) therapeutic or diagnostic derivatives of the described polynucleotides such as oligonucleotides, antisense polynucleotides, ribozymes, dsRNA, or gene therapy constructs comprising a sequence first disclosed in the Sequence Listing.

As discussed above, the present invention includes: (a) the human DNA sequences presented in the Sequence Listing (and vectors comprising the same) and additionally contemplates any nucleotide sequence encoding a contiguous NHP open reading frame (ORF) that hybridizes to a complement of a DNA sequence presented in the Sequence Listing under highly stringent conditions, e.g., hybridization to filter-bound DNA in 0.5 M NaHPO 4 , 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C., and washing in 0.1×SSC/0.1% SDS at 68° C. (Ausubel F. M. et al., eds., 1989, Current Protocols in Molecular Biology, Vol. I, Green Publishing Associates, Inc., and John Wiley & sons, Inc., New York, at p. 2.10.3) and encodes a functionally equivalent gene product. Additionally contemplated are any nucleotide sequences that hybridize to the complement of a DNA sequence that encodes and expresses an amino acid sequence presented in the Sequence Listing under moderately stringent conditions, e.g., washing in 0.2×SSC/0.1% SDS at 42° C. (Ausubel et al., 1989, supra), yet still encodes a functionally equivalent NHP product. Functional equivalents of a NHP include naturally occurring NHPs present in other species and mutant NHPs whether naturally occurring or engineered (by site directed mutagenesis, gene shuffling, directed evolution as described in, for example, U.S. Pat. No. 5,837,458). The invention also includes degenerate nucleic acid variants of the disclosed NHP polynucleotide sequences.

Additionally contemplated are polynucleotides encoding NHP ORFs, or their functional equivalents, encoded by polynucleotide sequences that are about 99, 95, 90, or about 85 percent similar or identical to corresponding regions of the nucleotide sequences of the Sequence Listing (as measured by BLAST sequence comparison analysis using, for example, the GCG sequence analysis package using standard default settings).

The invention also includes nucleic acid molecules, preferably DNA molecules, that hybridize to, and are therefore the complements of, the described NHP nucleotide sequences. Such hybridization conditions may be highly stringent or less highly stringent, as described above. In instances where the nucleic acid molecules are deoxyoligonucleotides (“DNA oligos”), such molecules are generally about 16 to about 100 bases long, or about 20 to about 80, or about 34 to about 45 bases long, or any variation or combination of sizes represented therein that incorporate a contiguous region of sequence first disclosed in the Sequence Listing. Such oligonucleotides can be used in conjunction with the polymerase chain reaction (PCR) to screen libraries, isolate clones, and prepare cloning and sequencing templates, etc.

Alternatively, such NHP oligonucleotides can be used as hybridization probes for screening libraries, and assessing gene expression patterns (particularly using a micro array or high-throughput “chip” format). Additionally, a series of the described NHP oligonucleotide sequences, or the complements thereof, can be used to represent all or a portion of the described NHP sequences. An oligonucleotide or polynucleotide sequence first disclosed in at least a portion of one or more of the sequences of SEQ ID NOS: 1-50 can be used as a hybridization probe in conjunction with a solid support matrix/substrate (resins, beads, membranes, plastics, polymers, metal or metallized substrates, crystalline or polycrystalline substrates, etc.). Of particular note are spatially addressable arrays (i.e., gene chips, microtiter plates, etc.) of oligonucleotides and polynucleotides, or corresponding oligopeptides and polypeptides, wherein at least one of the biopolymers present on the spatially addressable array comprises an oligonucleotide or polynucleotide sequence first disclosed in at least one of the sequences of SEQ ID NOS: 1-50, or an amino acid sequence encoded thereby. Methods for attaching biopolymers to, or synthesizing biopolymers on, solid support matrices, and conducting binding studies thereon are disclosed in, inter alia, U.S. Pat. Nos. 5,700,637, 5,556,752, 5,744,305, 4,631,211, 5,445,934, 5,252,743, 4,713,326, 5,424,186, and 4,689,405 the disclosures of which are herein incorporated by reference in their entirety.

Addressable arrays comprising sequences first disclosed in SEQ ID NOS:1-50 can be used to identify and characterize the temporal and tissue specific expression of a gene. These addressable arrays incorporate oligonucleotide sequences of sufficient length to confer the required specificity, yet be within the limitations of the production technology. The length of these probes is within a range of between about 8 to about 2000 nucleotides. Preferably the probes consist of 60 nucleotides and more preferably 25 nucleotides from the sequences first disclosed in SEQ ID NOS:1-50.

For example, a series of the described oligonucleotide sequences, or the complements thereof, can be used in chip format to represent all or a portion of the described sequences. The oligonucleotides, typically between about 16 to about 40 (or any whole number within the stated range) nucleotides in length can partially overlap each other and/or the sequence may be represented using oligonucleotides that do not overlap. Accordingly, the described polynucleotide sequences shall typically comprise at least about two or three distinct oligonucleotide sequences of at least about 8 nucleotides in length that are each first disclosed in the described Sequence Listing. Such oligonucleotide sequences can begin at any nucleotide present within a sequence in the Sequence Listing and proceed in either a sense (5′-to-3′) orientation vis-a-vis the described sequence or in an antisense orientation.

Microarray-based analysis allows the discovery of broad patterns of genetic activity, providing new understanding of gene functions and generating novel and unexpected insight into transcriptional processes and biological mechanisms. The use of addressable arrays comprising sequences first disclosed in SEQ ID NOS:1-50 provides detailed information about transcriptional changes involved in a specific pathway, potentially leading to the identification of novel components or gene functions that manifest themselves as novel phenotypes.

Probes consisting of sequences first disclosed in SEQ ID NOS:1-50 can also be used in the identification, selection and validation of novel molecular targets for drug discovery. The use of these unique sequences permits the direct confirmation of drug targets and recognition of drug dependent changes in gene expression that are modulated through pathways distinct from the drugs intended target. These unique sequences therefore also have utility in defining and monitoring both drug action and toxicity.

As an example of utility, the sequences first disclosed in SEQ ID NOS:1-50 can be utilized in microarrays or other assay formats, to screen collections of genetic material from patients who have a particular medical condition. These investigations can also be carried out using the sequences first disclosed in SEQ ID NOS:1-50 in silico and by comparing previously collected genetic databases and the disclosed sequences using computer software known to those in the art.

Thus the sequences first disclosed in SEQ ID NOS:1-50 can be used to identify mutations associated with a particular disease and also as a diagnostic or prognostic assay.

Although the presently described sequences have been specifically described using nucleotide sequence, it should be appreciated that each of the sequences can uniquely be described using any of a wide variety of additional structural attributes, or combinations thereof. For example, a given sequence can be described by the net composition of the nucleotides present within a given region of the sequence in conjunction with the presence of one or more specific oligonucleotide sequence(s) first disclosed in the SEQ ID NOS: 1-50. Alternatively, a restriction map specifying the relative positions of restriction endonuclease digestion sites, or various palindromic or other specific oligonucleotide sequences can be used to structurally describe a given sequence. Such restriction maps, which are typically generated by widely available computer programs (e.g., the University of Wisconsin GCG sequence analysis package, SEQUENCHER 3.0, Gene Codes Corp., Ann Arbor, Mich., etc.), can optionally be used in conjunction with one or more discrete nucleotide sequence(s) present in the sequence that can be described by the relative position of the sequence relatve to one or more additional sequence(s) or one or more restriction sites present in the disclosed sequence.

For oligonucleotide probes, highly stringent conditions may refer, e.g., to washing in 6×SSC/0.05% sodium pyrophosphate at 37° C. (for 14-base oligos), 48° C. (for 17-base oligos), 55° C. (for 20-base oligos), and 60° C. (for 23-base oligos). These nucleic acid molecules may encode or act as NHP gene antisense molecules, useful, for example, in NHP gene regulation (for and/or as antisense primers in amplification reactions of NHP gene nucleic acid sequences). With respect to NHP gene regulation, such techniques can be used to regulate biological functions. Further, such sequences may be used as part of ribozyme and/or triple helix sequences that are also useful for NHP gene regulation.

Inhibitory antisense or double stranded oligonucleotides can additionally comprise at least one modified base moiety which is selected from the group including but not limited to 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl)uracil, (acp3)w, and 2,6-diaminopurine.

The antisense oligonucleotide can also comprise at least one modified sugar moiety selected from the group including but not limited to arabinose, 2-fluoroarabinose, xylulose, and hexose.

In yet another embodiment, the antisense oligonucleotide will comprise at least one modified phosphate backbone selected from the group consisting of a phosphorothioate, a phosphorodithioate, a phosphoramidothioate, a phosphoramidate, a phosphordiamidate, a methylphosphonate, an alkyl phosphotriester, and a formacetal or analog thereof.

In yet another embodiment, the antisense oligonucleotide is an α-anomeric oligonucleotide. An α-anomeric oligonucleotide forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gautier et al., 1987, Nucl. Acids Res. 15:6625-6641). The oligonucleotide is a 2′-O-methylribonucleotide (Inoue et al., 1987, Nucl. Acids Res. 15:6131-6148), or a chimeric RNA-DNA analogue (Inoue et al., 1987, FEBS Lett. 215:327-330). Alternatively, double stranded RNA can be used to disrupt the expression and function of a targeted NHP.

Oligonucleotides of the invention can be synthesized by standard methods known in the art, e.g. by use of an automated DNA synthesizer (such as are commercially available from Biosearch, Applied Biosystems, etc.). As examples, phosphorothioate oligonucleotides can be synthesized by the method of Stein et al. (1988, Nucl. Acids Res. 16:3209), and methylphosphonate oligonucleotides can be prepared by use of controlled pore glass polymer supports (Sarin et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:7448-7451), etc.

Low stringency conditions are well known to those of skill in the art, and will vary predictably depending on the specific organisms from which the library and the labeled sequences are derived. For guidance regarding such conditions see, for example, Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual (and periodic updates thereof), Cold Springs Harbor Press, N.Y.; and Ausubel et al., 1989, Current Protocols in Molecular Biology, Green Publishing Associates and Wiley Interscience, N.Y.

Alternatively, suitably labeled NHP nucleotide probes can be used to screen a human genomic library using appropriately stringent conditions or by PCR. The identification and characterization of human genomic clones is helpful for identifying polymorphisms (including, but not limited to, nucleotide repeats, microsatellite alleles, single nucleotide polymorphisms, or coding single nucleotide polymorphisms), determining the genomic structure of a given locus/allele, and designing diagnostic tests. For example, sequences derived from regions adjacent to the intron/exon boundaries of the human gene can be used to design primers for use in amplification assays to detect mutations within the exons, introns, splice sites (e.g., splice acceptor and/or donor sites), etc., that can be used in diagnostics and pharmacogenomics.

Further, a NHP gene homolog can be isolated from nucleic acid from an organism of interest by performing PCR using two degenerate or “wobble” oligonucleotide primer pools designed on the basis of amino acid sequences within the NHP products disclosed herein. The template for the reaction may be total RNA, mRNA, and/or cDNA obtained by reverse transcription of mRNA prepared from human or non-human cell lines or tissue known or suspected to express an allele of a NHP gene.

The PCR product can be subcloned and sequenced to ensure that the amplified sequences represent the sequence of the desired NHP gene. The PCR fragment can then be used to isolate a full length cDNA clone by a variety of methods. For example, the amplified fragment can be labeled and used to screen a cDNA library, such as a bacteriophage cDNA library. Alternatively, the labeled fragment can be used to isolate genomic clones via the screening of a genomic library.

PCR technology can also be used to isolate full length cDNA sequences. For example, RNA can be isolated, following standard procedures, from an appropriate cellular or tissue source (i.e., one known, or suspected, to express a NHP gene). A reverse transcription (RT) reaction can be performed on the RNA using an oligonucleotide primer specific for the most 5′ end of the amplified fragment for the priming of first strand synthesis. The resulting RNA/DNA hybrid may then be “tailed” using a standard terminal transferase reaction, the hybrid may be digested with RNase H, and second strand synthesis may then be primed with a complementary primer. Thus, cDNA sequences upstream of the amplified fragment can be isolated. For a review of cloning strategies that can be used, see e.g., Sambrook et al., 1989, supra.

A cDNA encoding a mutant NHP gene can be isolated, for example, by using PCR. In this case, the first cDNA strand may be synthesized by hybridizing an oligo-dT oligonucleotide to mRNA isolated from tissue known or suspected to be expressed in an individual putatively carrying a mutant NHP allele, and by extending the new strand with reverse transcriptase. The second strand of the cDNA is then synthesized using an oligonucleotide that hybridizes specifically to the 5′ end of the normal gene. Using these two primers, the product is then amplified via PCR, optionally cloned into a suitable vector, and subjected to DNA sequence analysis through methods well known to those of skill in the art. By comparing the DNA sequence of the mutant NHP allele to that of a corresponding normal NHP allele, the mutation(s) responsible for the loss or alteration of function of the mutant NHP gene product can be ascertained.

Alternatively, a genomic library can be constructed using DNA obtained from an individual suspected of or known to carry a mutant NHP allele (e.g., a person manifesting a NHP-associated phenotype such as, for example, example, obesity, behavioral disorders, colitis or spastic colon, high blood pressure, depression, connective tissue disorders, infertility, etc.) or a cDNA library can be constructed using RNA from a tissue known, or suspected, to express a mutant NHP allele. A normal NHP gene, or any suitable fragment thereof, can then be labeled and used as a probe to identify the corresponding mutant NHP allele in such libraries. Clones containing mutant NHP gene sequences can then be purified and subjected to sequence analysis according to methods well known to those skilled in the art.

Additionally, an expression library can be constructed utilizing cDNA synthesized from, for example, RNA isolated from a tissue known, or suspected, to express a mutant NHP allele in an individual suspected of or known to carry such a mutant allele. In this manner, gene products made by the putatively mutant tissue can be expressed and screened using standard antibody screening techniques in conjunction with antibodies raised against a normal NHP product, as described below. (For screening techniques, see, for example, Harlow, E. and Lane, eds., 1988, “Antibodies: A Laboratory Manual”, Cold Spring Harbor Press, Cold Spring Harbor, N.Y.).

Additionally, screening can be accomplished by screening with labeled NHP fusion proteins, such as, for example, alkaline phosphatase-NHP or NHP-alkaline phosphatase fusion proteins. In cases where a NHP mutation results in an expressed gene product with altered function (e.g., as a result of a missense or a frameshift mutation), polyclonal antibodies to a NHP are likely to cross-react with a corresponding mutant NHP gene product. Library clones detected via their reaction with such labeled antibodies can be purified and subjected to sequence analysis according to methods well known in the art.

The invention also encompasses (a) DNA vectors that contain any of the foregoing NHP coding sequences and/or their complements (i.e., antisense); (b) DNA expression vectors that contain any of the foregoing NHP coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences (for example, baculo virus as described in U.S. Pat. No. 5,869,336 herein incorporated by reference); (c) genetically engineered host cells that contain any of the foregoing NHP coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences in the host cell; and (d) genetically engineered host cells that express an endogenous NHP gene under the control of an exogenously introduced regulatory element (i.e., gene activation). As used herein, regulatory elements include, but are not limited to, inducible and non-inducible promoters, enhancers, operators and other elements known to those skilled in the art that drive and regulate expression. Such regulatory elements include but are not limited to the cytomegalovirus (hCMV) immediate early gene, regulatable, viral elements (particularly retroviral LTR promoters), the early or late promoters of SV40 adenovirus, the lac system, the trp system, the TAC system, the TRC system, the major operator and promoter regions of phage lambda, the control regions of fd coat protein, the promoter for 3-phosphoglycerate kinase (PGK), the promoters of acid phosphatase, and the promoters of the yeast α-mating factors.

The present invention also encompasses antibodies and anti-idiotypic antibodies (including Fab fragments), antagonists and agonists of the NHP, as well as compounds or nucleotide constructs that inhibit expression of a NHP gene (transcription factor inhibitors, antisense and ribozyme molecules, or gene or regulatory sequence replacement constructs), or promote the expression of a NHP (e.g., expression constructs in which NHP coding sequences are operatively associated with expression control elements such as promoters, promoter/enhancers, etc.).

The NHPs or NHP peptides, NHP fusion proteins, NHP nucleotide sequences, antibodies, antagonists and agonists can be useful for the detection of mutant NHPs or inappropriately expressed NHPs for the diagnosis of disease. The NHP proteins or peptides, NHP fusion proteins, NHP nucleotide sequences, host cell expression systems, antibodies, antagonists, agonists and genetically engineered cells and animals can be used for screening for drugs (or high throughput screening of combinatorial libraries) effective in the treatment of the symptomatic or phenotypic manifestations of perturbing the normal function of NHP in the body. The use of engineered host cells and/or animals may offer an advantage in that such systems allow not only for the identification of compounds that bind to the endogenous receptor for an NHP, but can also identify compounds that trigger NHP-mediated activities or pathways.

Finally, the NHP products can be used as therapeutics. For example, soluble derivatives such as NHP peptides/domains corresponding to NHPs, NHP fusion protein products (especially NHP-Ig fusion proteins, i.e., fusions of a NHP, or a domain of a NHP, to an IgFc), NHP antibodies and anti-idiotypic antibodies (including Fab fragments), antagonists or agonists (including compounds that modulate or act on downstream targets in a NHP-mediated pathway) can be used to directly treat diseases or disorders. For instance, the administration of an effective amount of soluble NHP, or a NHP-IgFc fusion protein or an anti-idiotypic antibody (or its Fab) that mimics the NHP could activate or effectively antagonize the endogenous NHP receptor. Nucleotide constructs encoding such NHP products can be used to genetically engineer host cells to express such products in vivo; these genetically engineered cells function as “bioreactors” in the body delivering a continuous supply of a NHP, a NHP peptide, or a NHP fusion protein to the body. Nucleotide constructs encoding functional NHPs, mutant NHPs, as well as antisense and ribozyme molecules can also be used in “gene therapy” approaches for the modulation of NHP expression. Thus, the invention also encompasses pharmaceutical formulations and methods for treating biological disorders.

Various aspects of the invention are described in greater detail in the subsections below.

5.1 The NHP Sequences

The cDNA sequences and the corresponding deduced amino acid sequences of the described NHPs are presented in the Sequence Listing. The NHP nucleotides were obtained from clustered human gene trapped sequences, and cDNA products isolated from human brain and kidney mRNA (SEQ ID NOS: 1-17) and human fetal brain and kidney libraries (Edge Biosystems, Gaithersburg, Md.)(SEQ ID NOS 18-50).

The described sequences share substantial structural similarity with a variety of proteins, including, but not limited to, semaphorins G and F. Because of their potential medical significance, semaphorin protein homologs have been subject to considerable scientific scrutiny as evidenced in U.S. Pat. Nos. 5,981,222 and 6,013,781, which are herein incorporated by reference, and which describe various applications, uses, and compositions in which the presently described NHPs can be advantageously applied.

The NHP sequences described in SEQ ID NOS: 1-17 can contain a variety of polymorphisms such as A-G transitions that can occur in the sequence regions represented by nucleotide positions nos. 100, 232, and 406 of, for example, SEQ ID NO:1 that can give rise to a N or D being present at corresponding amino acid positions 34, 78, and 136 of SEQ ID NO:2, and a polymorphism at nucleotide position 1974 of, for example, SEQ ID NO:1 which can give rise to GTG being present or deleted which causes an accompanying presence or deletion of a V at corresponding amino acid position 658, for example, of SEQ ID NO:2.

The NHP sequences described in SEQ ID NOS: 18-50 can also contain a couple of polymorphisms such as a translationally silent C-T transition that can occur in the sequence regions represented by nucleotide position no. 804 of, for example, SEQ ID NO: 28, and a T-C transition at nucleotide position 2060 of, for example, SEQ ID NO:28 which can give rise to a L or a P being present at corresponding amino acid position 687 of, for example, SEQ ID NO:29.

An additional application of the described novel human polynucleotide sequences is their use in the molecular mutagenesis/evolution of proteins that are at least partially encoded by the described novel sequences using, for example, polynucleotide shuffling or related methodologies. Such approaches are described in U.S. Pat. Nos. 5,830,721 and 5,837,458 which are herein incorporated by reference in their entirety.

NHP gene products can also be expressed in transgenic animals. Animals of any species, including, but not limited to, worms, mice, rats, rabbits, guinea pigs, pigs, micro-pigs, birds, goats, and non-human primates, e.g., baboons, monkeys, and chimpanzees may be used to generate NHP transgenic animals.

Any technique known in the art may be used to introduce a NHP transgene into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to pronuclear microinjection (Hoppe, P. C. and Wagner, T. E., 1989, U.S. Pat. No. 4,873,191); retrovirus mediated gene transfer into germ lines (Van der Putten et al., 1985, Proc. Natl. Acad. Sci., USA 82:6148-6152); gene targeting in embryonic stem cells (Thompson et al., 1989, Cell 56:313-321); electroporation of embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814); and sperm-mediated gene transfer (Lavitrano et al., 1989, Cell 57:717-723); etc. For a review of such techniques, see Gordon, 1989, Transgenic Animals, Intl. Rev. Cytol. 115:171-229, which is incorporated by reference herein in its entirety.

The present invention provides for transgenic animals that carry the NHP transgene in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e., mosaic animals or somatic cell transgenic animals. The transgene may be integrated as a single transgene or in concatamers, e.g., head-to-head tandems or head-to-tail tandems. The transgene may also be selectively introduced into and activated in a particular cell type by following, for example, the teaching of Lasko et al., 1992, Proc. Natl. Acad. Sci. USA 89:6232-6236. The regulatory sequences required for such a cell-type specific activation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

When it is desired that a NHP transgene be integrated into the chromosomal site of the endogenous NHP gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous NHP gene are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of the nucleotide sequence of the endogenous NHP gene (i.e., “knockout” animals).

The transgene can also be selectively introduced into a particular cell type, thus inactivating the endogenous NHP gene in only that cell type, by following, for example, the teaching of Gu et al., 1994, Science, 265:103-106. The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

Once transgenic animals have been generated, the expression of the recombinant NHP gene may be assayed utilizing standard techniques. Initial screening may be accomplished by Southern blot analysis or PCR techniques to analyze animal tissues to assay whether integration of the transgene has taken place. The level of mRNA expression of the transgene in the tissues of the transgenic animals may also be assessed using techniques which include but are not limited to Northern blot analysis of tissue samples obtained from the animal, in situ hybridization analysis, and RT-PCR. Samples of NHP gene-expressing tissue, may also be evaluated immunocytochemically using antibodies specific for the NHP transgene product.

5.2 NHPS and NHP Polypeptides

NHPs, polypeptides, peptide fragments, mutated, truncated, or deleted forms of the NHPs, and/or NHP fusion proteins can be prepared for a variety of uses. These uses include but are not limited to the generation of antibodies, as reagents in diagnostic assays, the identification of other cellular gene products related to a NHP, as reagents in assays for screening for compounds that can be used as pharmaceutical reagents useful in the therapeutic treatment of mental, biological, or medical disorders and diseases. Given the similarity information and expression data, the described NHPs can be targeted (by drugs, oligos, antibodies, etc,) in order to treat disease, or to therapeutically augment the efficacy of, for example, chemotherapeutic agents used in the treatment of breast or prostate cancer.

The Sequence Listing discloses the amino acid sequences encoded by the described NHP polynucleotides. The NHPs typically display have initiator methionines in DNA sequence contexts consistent with a translation initiation site.

The NHP amino acid sequences of the invention include the amino acid sequence presented in the Sequence Listing as well as analogues and derivatives thereof. Further, corresponding NHP homologues from other species are encompassed by the invention. In fact, any NHP protein encoded by the NHP nucleotide sequences described above are within the scope of the invention, as are any novel polynucleotide sequences encoding all or any novel portion of an amino acid sequence presented in the Sequence Listing. The degenerate nature of the genetic code is well known, and, accordingly, each amino acid presented in the Sequence Listing, is generically representative of the well known nucleic acid “triplet” codon, or in many cases codons, that can encode the amino acid. As such, as contemplated herein, the amino acid sequences presented in the Sequence Listing, when taken together with the genetic code (see, for example, Table 4-1 at page 109 of “Molecular Cell Biology”, 1986, J. Darnell et al. eds., Scientific American Books, New York, N.Y., herein incorporated by reference) are generically representative of all the various permutations and combinations of nucleic acid sequences that can encode such amino acid sequences.

The invention also encompasses proteins that are functionally equivalent to the NHPs encoded by the presently described nucleotide sequences as judged by any of a number of criteria, including, but not limited to, the ability to bind and cleave a substrate of a NHP, or the ability to effect an identical or complementary downstream pathway, or a change in cellular metabolism (e.g., proteolytic activity, ion flux, tyrosine phosphorylation, etc.). Such functionally equivalent NHP proteins include, but are not limited to, additions or substitutions of amino acid residues within the amino acid sequence encoded by the NHP nucleotide sequences described above, but which result in a silent change, thus producing a functionally equivalent gene product. Amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid.

A variety of host-expression vector systems can be used to express the NHP nucleotide sequences of the invention. Where, as in the present instance, the NHP peptide or polypeptide is thought to be membrane protein, the hydrophobic regions of the protein can be excised and the resulting soluble peptide or polypeptide can be recovered from the culture media. Such expression systems also encompass engineered host cells that express a NHP, or functional equivalent, in situ. Purification or enrichment of a NHP from such expression systems can be accomplished using appropriate detergents and lipid micelles and methods well known to those skilled in the art. However, such engineered host cells themselves may be used in situations where it is important not only to retain the structural and functional characteristics of the NHP, but to assess biological activity, e.g., in drug screening assays.

The expression systems that may be used for purposes of the invention include but are not limited to microorganisms such as bacteria (e.g., E. coli, B. subtilis ) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing NHP nucleotide sequences; yeast (e.g., Saccharomyces, Pichia ) transformed with recombinant yeast expression vectors containing NHP nucleotide sequences; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing NHP sequences; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing NHP nucleotide sequences; or mammalian cell systems (e.g., COS, CHO, BHK, 293, 3T3) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5K promoter).

In bacterial systems, a number of expression vectors may be advantageously selected depending upon the use intended for the NHP product being expressed. For example, when a large quantity of such a protein is to be produced for the generation of pharmaceutical compositions of or containing NHP, or for raising antibodies to a NHP, vectors that direct the expression of high levels of fusion protein products that are readily purified may be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., 1983, EMBO J. 2:1791), in which a NHP coding sequence may be ligated individually into the vector in frame with the lacZ coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, 1985, Nucleic Acids Res. 13:3101-3109; Van Heeke & Schuster, 1989, J. Biol. Chem. 264:5503-5509); and the like. pGEX vectors (Pharmacia or American Type Culture Collection) can also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). In general, such fusion proteins are soluble and can easily be purified from lysed cells by adsorption to glutathione-agarose beads followed by elution in the presence of free glutathione. The PGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene product can be released from the GST moiety.

In an insect system, Autographa californica nuclear polyhidrosis virus (AcNPV) is used as a vector to express foreign genes. The virus grows in Spodoptera frugiperda cells. A NHP coding sequence may be cloned individually into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example the polyhedrin promoter). Successful insertion of NHP coding sequence will result in inactivation of the polyhedrin gene and production of non-occluded recombinant virus (i.e., virus lacking the proteinaceous coat coded for by the polyhedrin gene). These recombinant viruses are then used to infect Spodoptera frugiperda cells in which the inserted sequence is expressed (e.g., see Smith et al., 1983, J. Virol. 46:584; Smith, U.S. Pat. No. 4,215,051).

In mammalian host cells, a number of viral-based expression systems may be utilized. In cases where an adenovirus is used as an expression vector, the NHP nucleotide sequence of interest may be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene may then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non-essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing a NHP product in infected hosts (e.g., See Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659). Specific initiation signals may also be required for efficient translation of inserted NHP nucleotide sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire NHP gene or cDNA, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals may be needed. However, in cases where only a portion of a NHP coding sequence is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc. (See Bitter et al., 1987, Methods in Enzymol. 153:516-544).

In addition, a host cell strain may be chosen that modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products may be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins and gene products. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product may be used. Such mammalian host cells include, but are not limited to, CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3, WI38, and in particular, human cell lines.

For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the NHP sequences described above can be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells may be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method may advantageously be used to engineer cell lines which express the NHP product. Such engineered cell lines may be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the NHP product.

A number of selection systems may be used, including but not limited to the herpes simplex virus thymidine kinase (Wigler, et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc. Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy, et al., 1980, Cell 22:817) genes can be employed in tk − , hgprt − or aprt − cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for the following genes: dhfr, which confers resistance to methotrexate (Wigler, et al., 1980, Natl. Acad. Sci. USA 77:3567; O'Hare, et al., 1981, Proc. Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad. Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin, et al., 1981, J. Mol. Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre, et al., 1984, Gene 30:147).

Alternatively, any fusion protein can be readily purified by utilizing an antibody specific for the fusion protein being expressed. For example, a system described by Janknecht et al. allows for the ready purification of non-denatured fusion proteins expressed in human cell lines (Janknecht, et al., 1991, Proc. Natl. Acad. Sci. USA 88:8972-8976). In this system, the gene of interest is subcloned into a vaccinia recombination plasmid such that the gene's open reading frame is translationally fused to an amino-terminal tag consisting of six histidine residues. Extracts from cells infected with recombinant vaccinia virus are loaded onto Ni 2+ .nitriloacetic acid-agarose columns and histidine-tagged proteins are selectively eluted with imidazole-containing buffers.

Also encompassed by the present invention are fusion proteins that direct the NHP to a target organ and/or facilitate transport across the membrane into the cytosol. Conjugation of NHPs to antibody molecules or their Fab fragments could be used to target cells bearing a particular epitope. Attaching the appropriate signal sequence to the NHP would also transport the NHP to the desired location within the cell. Alternatively targeting of NHP or its nucleic acid sequence might be achieved using liposome or lipid complex based delivery systems. Such technologies are described in Liposomes:A Practical Approach , New,RRC ed., Oxford University Press, New York and in U.S. Pat. Nos. 4,594,595, 5,459,127, 5,948,767 and 6,110,490 and their respective disclosures which are herein incorporated by reference in their entirety. Additionally embodied are novel protein constructs engineered in such a way that they facilitate transport of the NHP to the target site or desired organ. This goal may be achieved by coupling of the NHP to a cytokine or other ligand that provides targeting specificity, and/or to a protein transducing domain (see generally U.S. application Ser. Nos. 60/111,701 and 60/056,713, both of which are herein incorporated by reference, for examples of such transducing sequences) to facilitate passage across cellular membranes if needed and can optionally be engineered to include nuclear localization sequences when desired.

5.3 Antibodies to NHP Products

Antibodies that specifically recognize one or more epitopes of a NHP, or epitopes of conserved variants of a NHP, or peptide fragments of a NHP are also encompassed by the invention. Such antibodies include but are not limited to polyclonal antibodies, monoclonal antibodies (mAbs), humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab′) 2 fragments, fragments produced by a Fab expression library, anti-idiotypic (anti-Id) antibodies, and epitope-binding fragments of any of the above.

The antibodies of the invention may be used, for example, in the detection of NHP in a biological sample and may, therefore, be utilized as part of a diagnostic or prognostic technique whereby patients may be tested for abnormal amounts of NHP. Such antibodies may also be utilized in conjunction with, for example, compound screening schemes for the evaluation of the effect of test compounds on expression and/or activity of a NHP gene product. Additionally, such antibodies can be used in conjunction gene therapy to, for example, evaluate the normal and/or engineered NHP-expressing cells prior to their introduction into the patient. Such antibodies may additionally be used as a method for the inhibition of abnormal NHP activity. Thus, such antibodies may, therefore, be utilized as part of treatment methods.

For the production of antibodies, various host animals may be immunized by injection with a NHP, an NHP peptide (e.g., one corresponding to a functional domain of an NHP), truncated NHP polypeptides (NHP in which one or more domains have been deleted), functional equivalents of the NHP or mutated variant of the NHP. Such host animals may include but are not limited to pigs, rabbits, mice, goats, and rats, to name but a few. Various adjuvants may be used to increase the immunological response, depending on the host species, including but not limited to Freund's adjuvant (complete and incomplete), mineral salts such as aluminum hydroxide or aluminum phosphate, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and Corynebacterium parvum . Alternatively, the immune response could be enhanced by combination and or coupling with molecules such as keyhole limpet hemocyanin, tetanus toxoid, diptheria toxoid, ovalbumin, cholera toxin or fragments thereof. Polyclonal antibodies are heterogeneous populations of antibody molecules derived from the sera of the immunized animals.

Monoclonal antibodies, which are homogeneous populations of antibodies to a particular antigen, can be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to, the hybridoma technique of Kohler and Milstein, (1975, Nature 256:495-497; and U.S. Pat. No. 4,376,110), the human B-cell hybridoma technique (Kosbor et al., 1983, Immunology Today 4:72; Cole et al., 1983, Proc. Natl. Acad. Sci. USA 80:2026-2030), and the EBV-hybridoma technique (Cole et al., 1985, Monoclonal Antibodies And Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The hybridoma producing the mAb of this invention may be cultivated in vitro or in vivo. Production of high titers of mAbs in vivo makes this the presently preferred method of production.

In addition, techniques developed for the production of “chimeric antibodies” (Morrison et al., 1984, Proc. Natl. Acad. Sci., 81:6851-6855; Neuberger et al., 1984, Nature, 312:604-608; Takeda et al., 1985, Nature, 314:452-454) by splicing the genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. A chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a murine mAb and a human immunoglobulin constant region. Such technologies are described in U.S. Pat. Nos. 6,075,181 and 5,877,397 and their respective disclosures which are herein incorporated by reference in their entirety. Also encompassed by the present invention is the use of fully humanized monoclonal antibodies as described in U.S. Pat. No. 6,150,584 and respective disclosures which are herein incorporated by reference in their entirety.

Alternatively, techniques described for the production of single chain antibodies (U.S. Pat. No. 4,946,778; Bird, 1988, Science 242:423-426; Huston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883; and Ward et al., 1989, Nature 341:544-546) can be adapted to produce single chain antibodies against NHP gene products. Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, resulting in a single chain polypeptide.

Antibody fragments which recognize specific epitopes may be generated by known techniques. For example, such fragments include, but are not limited to: the F(ab′) 2 fragments which can be produced by pepsin digestion of the antibody molecule and the Fab fragments which can be generated by reducing the disulfide bridges of the F(ab′) 2 fragments. Alternatively, Fab expression libraries may be constructed (Huse et al., 1989, Science, 246:1275-1281) to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity.

Antibodies to a NHP can, in turn, be utilized to generate anti-idiotype antibodies that “mimic” a given NHP, using techniques well known to those skilled in the art. (See, e.g., Greenspan & Bona, 1993, FASEB J 7(5):437-444; and Nissinoff, 1991, J. Immunol. 147(8):2429-2438). For example antibodies which bind to a NHP domain and competitively inhibit the binding of NHP to its cognate receptor can be used to generate anti-idiotypes that “mimic” the NHP and, therefore, bind and activate or neutralize a receptor. Such anti-idiotypic antibodies or Fab fragments of such anti-idiotypes can be used in therapeutic regimens involving a NHP mediated pathway.

The present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention, and functionally equivalent methods and components are within the scope of the invention. Indeed, various modifications of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description. Such modifications are intended to fall within the scope of the appended claims. All cited publications, patents, and patent applications are herein incorporated by reference in their entirety.

<160> NUMBER OF SEQ ID NOS: 50

<210> SEQ ID NO 1

<211> LENGTH: 3150

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 1

atgacggtgg ttaatccaca agacctgcag ccgtgggtct ctaacttcac ct

#accctgga     60

gcccgggatt tctcccagct ggctttggac ccctccgggr accagctcat cg

#tgggagcc    120

aggaactacc tcttcagact cagccttgcc aatgtctctc ttcttcaggc ca

#cagagtgg    180

gcctccagtg aggacacgcg ccgctcctgc caaagcaaag ggaagactga gg

#aggagtgt    240

cagaactacg tgcgagtcct gatcgtcgcc ggccggaagg tgttcatgtg tg

#gaaccaat    300

gccttttccc ccatgtgcac cagcagacag gtggggaacc tcagccggac ta

#ttgagaag    360

atcaatggtg tggcccgctg cccctatgac ccacgccaca actccacagc tg

#tcatctcc    420

tcccaggggg agctctatgc agccacggtc atcgacttct caggtcggga cc

#ctgccatc    480

taccgcagcc tgggcagtgg gccaccgctt cgcactgccc aatataactc ca

#agtggctt    540

aatgagccaa acttcgtggc agcctatgat attgggctgt ttgcatactt ct

#tcctgcgg    600

gagaacgcag tggagcacga ctgtggacgc accgtgtact ctcgcgtggc cc

#gcgtgtgc    660

aagaatgacg tggggggccg attcctgctg gaggacacat ggaccacatt ca

#tgaaggcc    720

cggctcaact gctcccgccc gggcgaggtc cccttctact ataacgagct gc

#agagtgcc    780

ttccacttgc crgagcagga cctcatctat ggagttttca caaccaacgt aa

#acagcaty    840

gcggcttctg ctgtctgcgc cttcaacctc agtgctatct cccaggcttt ca

#atggccca    900

tttcgctacc aggagaaccc cagggctgcc tggctcccca tagccaaccc ca

#tccccaat    960

ttccagtgtg gcaccctgcc tgagaccggt cccaacgaga acctgacgga gc

#gcagcctg   1020

caggacgcgc agcgcctctt cctgatgagc gaggccgtgc agccggtgac ac

#ccgagccc   1080

tgtgtcaccc aggacagcgt gcgcttctca cacctcgtgg tggacctggt gc

#aggctaaa   1140

gacacgctct accatgtact ctacattggc accgagtcgg gcaccatcct ga

#aggcgctg   1200

tccacggcga gccgcagcct ccacggctgc tacctggagg agctgcacgt gc

#tgcccccc   1260

gggcgccgcg agcccctgcg cagcctgcgc atcctgcaca gcgcccgcgc gc

#tcttcgtg   1320

gggctgagag acggcgtcct gcgggtccca ctggagaggt gcgccgccta cc

#gcagccag   1380

ggggcatgcc tgggggcccg ggacccgtac tgtggctggg acgggaagca gc

#aacgttgc   1440

agcacactcg aggacagctc caacatgagc ctctggaccc agaacatcac cg

#cctgtcct   1500

gtgcggaatg tgacacggga tgggggcttc ggcccatggt caccatggca ac

#catgtgag   1560

cacttggatg gggacaactc aggctcttgc ctgtgtcgag ctcgatcctg tg

#attcccct   1620

cgaccccgct gtgggggcct tgactgcctg gggccagcca tccacatcgc ca

#actgctcc   1680

aggaatgggg cgtggacccc gtggtcatcg tgggcgctgt gcagcacgtc ct

#gtggcatc   1740

ggcttccagg tccgccagcg aagttgcagc aaccctgctc cccgccacgg gg

#gccgcatc   1800

tgcgtgggca agagccggga ggaacggttc tgtaatgaga acacgccttg cc

#cggtgccc   1860

atcttctggg cttcctgggg ctcctggagc aagtgcagca gcaactgtgg ag

#ggggcatg   1920

cagtcgcggc gtcgggcctg cgagaacggc aactcctgcc tgggctgcgg cg

#tggagttc   1980

aagacgtgca accccgaggg ctgccccgaa gtgcggcgca acaccccctg ga

#cgccgtgg   2040

ctgcccgtga acgtgacgca gggcggggca cggcaggagc agcggttccg ct

#tcacctgc   2100

cgcgcgcccc ttgcagaccc gcacggcctg cagttcggca ggagaaggac cg

#agacgagg   2160

acctgtcccg cggacggctc cggctcctgc gacaccgacg ccctggtgga gg

#acctcctg   2220

cgcagcggga gcacctcccc gcacacggtg agcgggggct gggccgcctg gg

#gcccgtgg   2280

tcgtcctgct cccgggactg cgagctgggc ttccgcgtcc gcaagagaac gt

#gcactaac   2340

ccggagcccc gcaacggggg cctgccctgc gtgggcgatg ctgccgagta cc

#aggactgc   2400

aacccccagg cttgcccagt tcggggtgct tggtcctgct ggacctcatg gt

#ctccatgc   2460

tcagcttcct gtggtggggg tcactatcaa cgcacccgtt cctgcaccag cc

#ccgcaccc   2520

tccccaggtg aggacatctg tctcgggctg cacacggagg aggcactatg tg

#ccacacag   2580

gcctgcccag aaggctggtc gccctggtct gagtggagta agtgcactga cg

#acggagcc   2640

cagagccgaa gccggcactg tgaggagctc ctcccagggt ccagcgcctg tg

#ctggaaac   2700

agcagccaga gccgcccctg cccctacagc gagattcccg tcatcctgcc ag

#cctccagc   2760

atggaggagg ccaccggctg tgcagggttc aatctcatcc acttggtggc ca

#cgggcatc   2820

tcctgcttct tgggctctgg gctcctgacc ctagcagtgt acctgtcttg cc

#agcactgc   2880

cagcgtcagt cccaggagtc cacactggtc catcctgcca cccccaacca tt

#tgcactac   2940

aagggcggag gcaccccgaa gaatgaaaag tacacaccca tggaattcaa ga

#ccctgaac   3000

aagaataact tgatccctga tgacagagcc aacttctacc cattgcagca ga

#ccaatgtg   3060

tacacgacta cttactaccc aagccccctg aacaaacaca gcttccggcc cg

#aggcctca   3120

cctggacaac ggtgcttccc caacagctga

#

#         3150

<210> SEQ ID NO 2

<211> LENGTH: 1049

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 2

Met Thr Val Val Asn Pro Gln Asp Leu Gln Pr

#o Trp Val Ser Asn Phe

1               5

#                10

#                15

Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln Le

#u Ala Leu Asp Pro Ser

20

#            25

#            30

Gly Asn Gln Leu Ile Val Gly Ala Arg Asn Ty

#r Leu Phe Arg Leu Ser

35

#        40

#        45

Leu Ala Asn Val Ser Leu Leu Gln Ala Thr Gl

#u Trp Ala Ser Ser Glu

50

#    55

#    60

Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly Ly

#s Thr Glu Glu Glu Cys

65

#70

#75

#80

Gln Asn Tyr Val Arg Val Leu Ile Val Ala Gl

#y Arg Lys Val Phe Met

85

#                90

#                95

Cys Gly Thr Asn Ala Phe Ser Pro Met Cys Th

#r Ser Arg Gln Val Gly

100

#           105

#           110

Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn Gl

#y Val Ala Arg Cys Pro

115

#       120

#       125

Tyr Asp Pro Arg His Asn Ser Thr Ala Val Il

#e Ser Ser Gln Gly Glu

130

#   135

#   140

Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser Gl

#y Arg Asp Pro Ala Ile

145                 1

#50                 1

#55                 1

#60

Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu Ar

#g Thr Ala Gln Tyr Asn

165

#               170

#               175

Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Al

#a Ala Tyr Asp Ile Gly

180

#           185

#           190

Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn Al

#a Val Glu His Asp Cys

195

#       200

#       205

Gly Arg Thr Val Tyr Ser Arg Val Ala Arg Va

#l Cys Lys Asn Asp Val

210

#   215

#   220

Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Th

#r Thr Phe Met Lys Ala

225                 2

#30                 2

#35                 2

#40

Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pr

#o Phe Tyr Tyr Asn Glu

245

#               250

#               255

Leu Gln Ser Ala Phe His Leu Pro Glu Gln As

#p Leu Ile Tyr Gly Val

260

#           265

#           270

Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Se

#r Ala Val Cys Ala Phe

275

#       280

#       285

Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn Gl

#y Pro Phe Arg Tyr Gln

290

#   295

#   300

Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile Al

#a Asn Pro Ile Pro Asn

305                 3

#10                 3

#15                 3

#20

Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly Pr

#o Asn Glu Asn Leu Thr

325

#               330

#               335

Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu Ph

#e Leu Met Ser Glu Ala

340

#           345

#           350

Val Gln Pro Val Thr Pro Glu Pro Cys Val Th

#r Gln Asp Ser Val Arg

355

#       360

#       365

Phe Ser His Leu Val Val Asp Leu Val Gln Al

#a Lys Asp Thr Leu Tyr

370

#   375

#   380

His Val Leu Tyr Ile Gly Thr Glu Ser Gly Th

#r Ile Leu Lys Ala Leu

385                 3

#90                 3

#95                 4

#00

Ser Thr Ala Ser Arg Ser Leu His Gly Cys Ty

#r Leu Glu Glu Leu His

405

#               410

#               415

Val Leu Pro Pro Gly Arg Arg Glu Pro Leu Ar

#g Ser Leu Arg Ile Leu

420

#           425

#           430

His Ser Ala Arg Ala Leu Phe Val Gly Leu Ar

#g Asp Gly Val Leu Arg

435

#       440

#       445

Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg Se

#r Gln Gly Ala Cys Leu

450

#   455

#   460

Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gl

#y Lys Gln Gln Arg Cys

465                 4

#70                 4

#75                 4

#80

Ser Thr Leu Glu Asp Ser Ser Asn Met Ser Le

#u Trp Thr Gln Asn Ile

485

#               490

#               495

Thr Ala Cys Pro Val Arg Asn Val Thr Arg As

#p Gly Gly Phe Gly Pro

500

#           505

#           510

Trp Ser Pro Trp Gln Pro Cys Glu His Leu As

#p Gly Asp Asn Ser Gly

515

#       520

#       525

Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp Se

#r Pro Arg Pro Arg Cys

530

#   535

#   540

Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile Hi

#s Ile Ala Asn Cys Ser

545                 5

#50                 5

#55                 5

#60

Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser Tr

#p Ala Leu Cys Ser Thr

565

#               570

#               575

Ser Cys Gly Ile Gly Phe Gln Val Arg Gln Ar

#g Ser Cys Ser Asn Pro

580

#           585

#           590

Ala Pro Arg His Gly Gly Arg Ile Cys Val Gl

#y Lys Ser Arg Glu Glu

595

#       600

#       605

Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro Va

#l Pro Ile Phe Trp Ala

610

#   615

#   620

Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser As

#n Cys Gly Gly Gly Met

625                 6

#30                 6

#35                 6

#40

Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly As

#n Ser Cys Leu Gly Cys

645

#               650

#               655

Gly Val Glu Phe Lys Thr Cys Asn Pro Glu Gl

#y Cys Pro Glu Val Arg

660

#           665

#           670

Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Va

#l Asn Val Thr Gln Gly

675

#       680

#       685

Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Th

#r Cys Arg Ala Pro Leu

690

#   695

#   700

Ala Asp Pro His Gly Leu Gln Phe Gly Arg Ar

#g Arg Thr Glu Thr Arg

705                 7

#10                 7

#15                 7

#20

Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys As

#p Thr Asp Ala Leu Val

725

#               730

#               735

Glu Asp Leu Leu Arg Ser Gly Ser Thr Ser Pr

#o His Thr Val Ser Gly

740

#           745

#           750

Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cy

#s Ser Arg Asp Cys Glu

755

#       760

#       765

Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Th

#r Asn Pro Glu Pro Arg

770

#   775

#   780

Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Al

#a Glu Tyr Gln Asp Cys

785                 7

#90                 7

#95                 8

#00

Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Tr

#p Ser Cys Trp Thr Ser

805

#               810

#               815

Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gl

#y His Tyr Gln Arg Thr

820

#           825

#           830

Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gl

#y Glu Asp Ile Cys Leu

835

#       840

#       845

Gly Leu His Thr Glu Glu Ala Leu Cys Ala Th

#r Gln Ala Cys Pro Glu

850

#   855

#   860

Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cy

#s Thr Asp Asp Gly Ala

865                 8

#70                 8

#75                 8

#80

Gln Ser Arg Ser Arg His Cys Glu Glu Leu Le

#u Pro Gly Ser Ser Ala

885

#               890

#               895

Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cy

#s Pro Tyr Ser Glu Ile

900

#           905

#           910

Pro Val Ile Leu Pro Ala Ser Ser Met Glu Gl

#u Ala Thr Gly Cys Ala

915

#       920

#       925

Gly Phe Asn Leu Ile His Leu Val Ala Thr Gl

#y Ile Ser Cys Phe Leu

930

#   935

#   940

Gly Ser Gly Leu Leu Thr Leu Ala Val Tyr Le

#u Ser Cys Gln His Cys

945                 9

#50                 9

#55                 9

#60

Gln Arg Gln Ser Gln Glu Ser Thr Leu Val Hi

#s Pro Ala Thr Pro Asn

965

#               970

#               975

His Leu His Tyr Lys Gly Gly Gly Thr Pro Ly

#s Asn Glu Lys Tyr Thr

980

#           985

#           990

Pro Met Glu Phe Lys Thr Leu Asn Lys Asn As

#n Leu Ile Pro Asp Asp

995

#       1000

#      1005

Arg Ala Asn Phe Tyr Pro Leu Gln Gln Thr As

#n Val Tyr Thr Thr Thr

1010

#   1015

#  1020

Tyr Tyr Pro Ser Pro Leu Asn Lys His Ser Ph

#e Arg Pro Glu Ala Ser

1025                1030

#                1035

#               1040

Pro Gly Gln Arg Cys Phe Pro Asn Ser

1045

<210> SEQ ID NO 3

<211> LENGTH: 3282

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 3

atggtgcttg caggccccct ggctgtctcg ctgttgctgc ccagcctcac ac

#tgctggtg     60

tcccacctct ccagctccca ggatgtctcc agtgagccca gcagtgagca gc

#agctgtgc    120

gcccttagca agcaccccac cgtggccttt gaagacctgc agccgtgggt ct

#ctaacttc    180

acctaccctg gagcccggga tttctcccag ctggctttgg acccctccgg gr

#accagctc    240

atcgtgggag ccaggaacta cctcttcaga ctcagccttg ccaatgtctc tc

#ttcttcag    300

gccacagagt gggcctccag tgaggacacg cgccgctcct gccaaagcaa ag

#ggaagact    360

gaggaggagt gtcagaacta cgtgcgagtc ctgatcgtcg ccggccggaa gg

#tgttcatg    420

tgtggaacca atgccttttc ccccatgtgc accagcagac aggtggggaa cc

#tcagccgg    480

actattgaga agatcaatgg tgtggcccgc tgcccctatg acccacgcca ca

#actccaca    540

gctgtcatct cctcccaggg ggagctctat gcagccacgg tcatcgactt ct

#caggtcgg    600

gaccctgcca tctaccgcag cctgggcagt gggccaccgc ttcgcactgc cc

#aatataac    660

tccaagtggc ttaatgagcc aaacttcgtg gcagcctatg atattgggct gt

#ttgcatac    720

ttcttcctgc gggagaacgc agtggagcac gactgtggac gcaccgtgta ct

#ctcgcgtg    780

gcccgcgtgt gcaagaatga cgtggggggc cgattcctgc tggaggacac at

#ggaccaca    840

ttcatgaagg cccggctcaa ctgctcccgc ccgggcgagg tccccttcta ct

#ataacgag    900

ctgcagagtg ccttccactt gccrgagcag gacctcatct atggagtttt ca

#caaccaac    960

gtaaacagca tygcggcttc tgctgtctgc gccttcaacc tcagtgctat ct

#cccaggct   1020

ttcaatggcc catttcgcta ccaggagaac cccagggctg cctggctccc ca

#tagccaac   1080

cccatcccca atttccagtg tggcaccctg cctgagaccg gtcccaacga ga

#acctgacg   1140

gagcgcagcc tgcaggacgc gcagcgcctc ttcctgatga gcgaggccgt gc

#agccggtg   1200

acacccgagc cctgtgtcac ccaggacagc gtgcgcttct cacacctcgt gg

#tggacctg   1260

gtgcaggcta aagacacgct ctaccatgta ctctacattg gcaccgagtc gg

#gcaccatc   1320

ctgaaggcgc tgtccacggc gagccgcagc ctccacggct gctacctgga gg

#agctgcac   1380

gtgctgcccc ccgggcgccg cgagcccctg cgcagcctgc gcatcctgca ca

#gcgcccgc   1440

gcgctcttcg tggggctgag agacggcgtc ctgcgggtcc cactggagag gt

#gcgccgcc   1500

taccgcagcc agggggcatg cctgggggcc cgggacccgt actgtggctg gg

#acgggaag   1560

cagcaacgtt gcagcacact cgaggacagc tccaacatga gcctctggac cc

#agaacatc   1620

accgcctgtc ctgtgcggaa tgtgacacgg gatgggggct tcggcccatg gt

#caccatgg   1680

caaccatgtg agcacttgga tggggacaac tcaggctctt gcctgtgtcg ag

#ctcgatcc   1740

tgtgattccc ctcgaccccg ctgtgggggc cttgactgcc tggggccagc ca

#tccacatc   1800

gccaactgct ccaggaatgg ggcgtggacc ccgtggtcat cgtgggcgct gt

#gcagcacg   1860

tcctgtggca tcggcttcca ggtccgccag cgaagttgca gcaaccctgc tc

#cccgccac   1920

gggggccgca tctgcgtggg caagagccgg gaggaacggt tctgtaatga ga

#acacgcct   1980

tgcccggtgc ccatcttctg ggcttcctgg ggctcctgga gcaagtgcag ca

#gcaactgt   2040

ggagggggca tgcagtcgcg gcgtcgggcc tgcgagaacg gcaactcctg cc

#tgggctgc   2100

ggcgtggagt tcaagacgtg caaccccgag ggctgccccg aagtgcggcg ca

#acaccccc   2160

tggacgccgt ggctgcccgt gaacgtgacg cagggcgggg cacggcagga gc

#agcggttc   2220

cgcttcacct gccgcgcgcc ccttgcagac ccgcacggcc tgcagttcgg ca

#ggagaagg   2280

accgagacga ggacctgtcc cgcggacggc tccggctcct gcgacaccga cg

#ccctggtg   2340

gaggacctcc tgcgcagcgg gagcacctcc ccgcacacgg tgagcggggg ct

#gggccgcc   2400

tggggcccgt ggtcgtcctg ctcccgggac tgcgagctgg gcttccgcgt cc

#gcaagaga   2460

acgtgcacta acccggagcc ccgcaacggg ggcctgccct gcgtgggcga tg

#ctgccgag   2520

taccaggact gcaaccccca ggcttgccca gttcggggtg cttggtcctg ct

#ggacctca   2580

tggtctccat gctcagcttc ctgtggtggg ggtcactatc aacgcacccg tt

#cctgcacc   2640

agccccgcac cctccccagg tgaggacatc tgtctcgggc tgcacacgga gg

#aggcacta   2700

tgtgccacac aggcctgccc agaaggctgg tcgccctggt ctgagtggag ta

#agtgcact   2760

gacgacggag cccagagccg aagccggcac tgtgaggagc tcctcccagg gt

#ccagcgcc   2820

tgtgctggaa acagcagcca gagccgcccc tgcccctaca gcgagattcc cg

#tcatcctg   2880

ccagcctcca gcatggagga ggccaccggc tgtgcagggt tcaatctcat cc

#acttggtg   2940

gccacgggca tctcctgctt cttgggctct gggctcctga ccctagcagt gt

#acctgtct   3000

tgccagcact gccagcgtca gtcccaggag tccacactgg tccatcctgc ca

#cccccaac   3060

catttgcact acaagggcgg aggcaccccg aagaatgaaa agtacacacc ca

#tggaattc   3120

aagaccctga acaagaataa cttgatccct gatgacagag ccaacttcta cc

#cattgcag   3180

cagaccaatg tgtacacgac tacttactac ccaagccccc tgaacaaaca ca

#gcttccgg   3240

cccgaggcct cacctggaca acggtgcttc cccaacagct ga

#

#3282

<210> SEQ ID NO 4

<211> LENGTH: 1093

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 4

Met Val Leu Ala Gly Pro Leu Ala Val Ser Le

#u Leu Leu Pro Ser Leu

1               5

#                10

#                15

Thr Leu Leu Val Ser His Leu Ser Ser Ser Gl

#n Asp Val Ser Ser Glu

20

#            25

#            30

Pro Ser Ser Glu Gln Gln Leu Cys Ala Leu Se

#r Lys His Pro Thr Val

35

#        40

#        45

Ala Phe Glu Asp Leu Gln Pro Trp Val Ser As

#n Phe Thr Tyr Pro Gly

50

#    55

#    60

Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pr

#o Ser Gly Asn Gln Leu

65

#70

#75

#80

Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Le

#u Ser Leu Ala Asn Val

85

#                90

#                95

Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Se

#r Glu Asp Thr Arg Arg

100

#           105

#           110

Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Gl

#u Cys Gln Asn Tyr Val

115

#       120

#       125

Arg Val Leu Ile Val Ala Gly Arg Lys Val Ph

#e Met Cys Gly Thr Asn

130

#   135

#   140

Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Va

#l Gly Asn Leu Ser Arg

145                 1

#50                 1

#55                 1

#60

Thr Ile Glu Lys Ile Asn Gly Val Ala Arg Cy

#s Pro Tyr Asp Pro Arg

165

#               170

#               175

His Asn Ser Thr Ala Val Ile Ser Ser Gln Gl

#y Glu Leu Tyr Ala Ala

180

#           185

#           190

Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Al

#a Ile Tyr Arg Ser Leu

195

#       200

#       205

Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Ty

#r Asn Ser Lys Trp Leu

210

#   215

#   220

Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Il

#e Gly Leu Phe Ala Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Leu Arg Glu Asn Ala Val Glu His As

#p Cys Gly Arg Thr Val

245

#               250

#               255

Tyr Ser Arg Val Ala Arg Val Cys Lys Asn As

#p Val Gly Gly Arg Phe

260

#           265

#           270

Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Ly

#s Ala Arg Leu Asn Cys

275

#       280

#       285

Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr As

#n Glu Leu Gln Ser Ala

290

#   295

#   300

Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gl

#y Val Phe Thr Thr Asn

305                 3

#10                 3

#15                 3

#20

Val Asn Ser Ile Ala Ala Ser Ala Val Cys Al

#a Phe Asn Leu Ser Ala

325

#               330

#               335

Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Ty

#r Gln Glu Asn Pro Arg

340

#           345

#           350

Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pr

#o Asn Phe Gln Cys Gly

355

#       360

#       365

Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Le

#u Thr Glu Arg Ser Leu

370

#   375

#   380

Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Gl

#u Ala Val Gln Pro Val

385                 3

#90                 3

#95                 4

#00

Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Va

#l Arg Phe Ser His Leu

405

#               410

#               415

Val Val Asp Leu Val Gln Ala Lys Asp Thr Le

#u Tyr His Val Leu Tyr

420

#           425

#           430

Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Al

#a Leu Ser Thr Ala Ser

435

#       440

#       445

Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Le

#u His Val Leu Pro Pro

450

#   455

#   460

Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Il

#e Leu His Ser Ala Arg

465                 4

#70                 4

#75                 4

#80

Ala Leu Phe Val Gly Leu Arg Asp Gly Val Le

#u Arg Val Pro Leu Glu

485

#               490

#               495

Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cy

#s Leu Gly Ala Arg Asp

500

#           505

#           510

Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Ar

#g Cys Ser Thr Leu Glu

515

#       520

#       525

Asp Ser Ser Asn Met Ser Leu Trp Thr Gln As

#n Ile Thr Ala Cys Pro

530

#   535

#   540

Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gl

#y Pro Trp Ser Pro Trp

545                 5

#50                 5

#55                 5

#60

Gln Pro Cys Glu His Leu Asp Gly Asp Asn Se

#r Gly Ser Cys Leu Cys

565

#               570

#               575

Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Ar

#g Cys Gly Gly Leu Asp

580

#           585

#           590

Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cy

#s Ser Arg Asn Gly Ala

595

#       600

#       605

Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Se

#r Thr Ser Cys Gly Ile

610

#   615

#   620

Gly Phe Gln Val Arg Gln Arg Ser Cys Ser As

#n Pro Ala Pro Arg His

625                 6

#30                 6

#35                 6

#40

Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Gl

#u Glu Arg Phe Cys Asn

645

#               650

#               655

Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Tr

#p Ala Ser Trp Gly Ser

660

#           665

#           670

Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gl

#y Met Gln Ser Arg Arg

675

#       680

#       685

Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gl

#y Cys Gly Val Glu Phe

690

#   695

#   700

Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Va

#l Arg Arg Asn Thr Pro

705                 7

#10                 7

#15                 7

#20

Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gl

#n Gly Gly Ala Arg Gln

725

#               730

#               735

Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pr

#o Leu Ala Asp Pro His

740

#           745

#           750

Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Th

#r Arg Thr Cys Pro Ala

755

#       760

#       765

Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Le

#u Val Glu Asp Leu Leu

770

#   775

#   780

Arg Ser Gly Ser Thr Ser Pro His Thr Val Se

#r Gly Gly Trp Ala Ala

785                 7

#90                 7

#95                 8

#00

Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cy

#s Glu Leu Gly Phe Arg

805

#               810

#               815

Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pr

#o Arg Asn Gly Gly Leu

820

#           825

#           830

Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln As

#p Cys Asn Pro Gln Ala

835

#       840

#       845

Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Th

#r Ser Trp Ser Pro Cys

850

#   855

#   860

Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Ar

#g Thr Arg Ser Cys Thr

865                 8

#70                 8

#75                 8

#80

Ser Pro Ala Pro Ser Pro Gly Glu Asp Ile Cy

#s Leu Gly Leu His Thr

885

#               890

#               895

Glu Glu Ala Leu Cys Ala Thr Gln Ala Cys Pr

#o Glu Gly Trp Ser Pro

900

#           905

#           910

Trp Ser Glu Trp Ser Lys Cys Thr Asp Asp Gl

#y Ala Gln Ser Arg Ser

915

#       920

#       925

Arg His Cys Glu Glu Leu Leu Pro Gly Ser Se

#r Ala Cys Ala Gly Asn

930

#   935

#   940

Ser Ser Gln Ser Arg Pro Cys Pro Tyr Ser Gl

#u Ile Pro Val Ile Leu

945                 9

#50                 9

#55                 9

#60

Pro Ala Ser Ser Met Glu Glu Ala Thr Gly Cy

#s Ala Gly Phe Asn Leu

965

#               970

#               975

Ile His Leu Val Ala Thr Gly Ile Ser Cys Ph

#e Leu Gly Ser Gly Leu

980

#           985

#           990

Leu Thr Leu Ala Val Tyr Leu Ser Cys Gln Hi

#s Cys Gln Arg Gln Ser

995

#       1000

#      1005

Gln Glu Ser Thr Leu Val His Pro Ala Thr Pr

#o Asn His Leu His Tyr

1010

#   1015

#  1020

Lys Gly Gly Gly Thr Pro Lys Asn Glu Lys Ty

#r Thr Pro Met Glu Phe

1025                1030

#                1035

#               1040

Lys Thr Leu Asn Lys Asn Asn Leu Ile Pro As

#p Asp Arg Ala Asn Phe

1045

#               1050

#              1055

Tyr Pro Leu Gln Gln Thr Asn Val Tyr Thr Th

#r Thr Tyr Tyr Pro Ser

1060

#           1065

#          1070

Pro Leu Asn Lys His Ser Phe Arg Pro Glu Al

#a Ser Pro Gly Gln Arg

1075

#       1080

#      1085

Cys Phe Pro Asn Ser

1090

<210> SEQ ID NO 5

<211> LENGTH: 3105

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 5

atgacggtgg ttaatccaca agacctgcag ccgtgggtct ctaacttcac ct

#accctgga     60

gcccgggatt tctcccagct ggctttggac ccctccgggr accagctcat cg

#tgggagcc    120

aggaactacc tcttcagact cagccttgcc aatgtctctc ttcttcaggc ca

#cagagtgg    180

gcctccagtg aggacacgcg ccgctcctgc caaagcaaag ggaagactga gg

#aggagtgt    240

cagaactacg tgcgagtcct gatcgtcgcc ggccggaagg tgttcatgtg tg

#gaaccaat    300

gccttttccc ccatgtgcac cagcagacag gtggggaacc tcagccggac ta

#ttgagaag    360

atcaatggtg tggcccgctg cccctatgac ccacgccaca actccacagc tg

#tcatctcc    420

tcccaggggg agctctatgc agccacggtc atcgacttct caggtcggga cc

#ctgccatc    480

taccgcagcc tgggcagtgg gccaccgctt cgcactgccc aatataactc ca

#agtggctt    540

aatgagccaa acttcgtggc agcctatgat attgggctgt ttgcatactt ct

#tcctgcgg    600

gagaacgcag tggagcacga ctgtggacgc accgtgtact ctcgcgtggc cc

#gcgtgtgc    660

aagaatgacg tggggggccg attcctgctg gaggacacat ggaccacatt ca

#tgaaggcc    720

cggctcaact gctcccgccc gggcgaggtc cccttctact ataacgagct gc

#agagtgcc    780

ttccacttgc crgagcagga cctcatctat ggagttttca caaccaacgt aa

#acagcaty    840

gcggcttctg ctgtctgcgc cttcaacctc agtgctatct cccaggcttt ca

#atggccca    900

tttcgctacc aggagaaccc cagggctgcc tggctcccca tagccaaccc ca

#tccccaat    960

ttccagtgtg gcaccctgcc tgagaccggt cccaacgaga acctgacgga gc

#gcagcctg   1020

caggacgcgc agcgcctctt cctgatgagc gaggccgtgc agccggtgac ac

#ccgagccc   1080

tgtgtcaccc aggacagcgt gcgcttctca cacctcgtgg tggacctggt gc

#aggctaaa   1140

gacacgctct accatgtact ctacattggc accgagtcgg gcaccatcct ga

#aggcgctg   1200

tccacggcga gccgcagcct ccacggctgc tacctggagg agctgcacgt gc

#tgcccccc   1260

gggcgccgcg agcccctgcg cagcctgcgc atcctgcaca gcgcccgcgc gc

#tcttcgtg   1320

gggctgagag acggcgtcct gcgggtccca ctggagaggt gcgccgccta cc

#gcagccag   1380

ggggcatgcc tgggggcccg ggacccgtac tgtggctggg acgggaagca gc

#aacgttgc   1440

agcacactcg aggacagctc caacatgagc ctctggaccc agaacatcac cg

#cctgtcct   1500

gtgcggaatg tgacacggga tgggggcttc ggcccatggt caccatggca ac

#catgtgag   1560

cacttggatg gggacaactc aggctcttgc ctgtgtcgag ctcgatcctg tg

#attcccct   1620

cgaccccgct gtgggggcct tgactgcctg gggccagcca tccacatcgc ca

#actgctcc   1680

aggaatgggg cgtggacccc gtggtcatcg tgggcgctgt gcagcacgtc ct

#gtggcatc   1740

ggcttccagg tccgccagcg aagttgcagc aaccctgctc cccgccacgg gg

#gccgcatc   1800

tgcgtgggca agagccggga ggaacggttc tgtaatgaga acacgccttg cc

#cggtgccc   1860

atcttctggg cttcctgggg ctcctggagc aagtgcagca gcaactgtgg ag

#ggggcatg   1920

cagtcgcggc gtcgggcctg cgagaacggc aactcctgcc tgggctgcgg cg

#tggagttc   1980

aagacgtgca accccgaggg ctgccccgaa gtgcggcgca acaccccctg ga

#cgccgtgg   2040

ctgcccgtga acgtgacgca gggcggggca cggcaggagc agcggttccg ct

#tcacctgc   2100

cgcgcgcccc ttgcagaccc gcacggcctg cagttcggca ggagaaggac cg

#agacgagg   2160

acctgtcccg cggacggctc cggctcctgc gacaccgacg ccctggtgga gg

#acctcctg   2220

cgcagcggga gcacctcccc gcacacggtg agcgggggct gggccgcctg gg

#gcccgtgg   2280

tcgtcctgct cccgggactg cgagctgggc ttccgcgtcc gcaagagaac gt

#gcactaac   2340

ccggagcccc gcaacggggg cctgccctgc gtgggcgatg ctgccgagta cc

#aggactgc   2400

aacccccagg cttgcccagt tcggggtgct tggtcctgct ggacctcatg gt

#ctccatgc   2460

tcagcttcct gtggtggggg tcactatcaa cgcacccgtt cctgcaccag cc

#ccgcaccc   2520

tccccaggtg aggacatctg tctcgggctg cacacggagg aggcactatg tg

#ccacacag   2580

gcctgcccag aaggctggtc gccctggtct gagtggagta agtgcactga cg

#acggagcc   2640

cagagccgaa gccggcactg tgaggagctc ctcccagggt ccagcgcctg tg

#ctggaaac   2700

agcagccaga gccgcccctg cccctacagc gagattcccg ggttcaatct ca

#tccacttg   2760

gtggccacgg gcatctcctg cttcttgggc tctgggctcc tgaccctagc ag

#tgtacctg   2820

tcttgccagc actgccagcg tcagtcccag gagtccacac tggtccatcc tg

#ccaccccc   2880

aaccatttgc actacaaggg cggaggcacc ccgaagaatg aaaagtacac ac

#ccatggaa   2940

ttcaagaccc tgaacaagaa taacttgatc cctgatgaca gagccaactt ct

#acccattg   3000

cagcagacca atgtgtacac gactacttac tacccaagcc ccctgaacaa ac

#acagcttc   3060

cggcccgagg cctcacctgg acaacggtgc ttccccaaca gctga

#                3105

<210> SEQ ID NO 6

<211> LENGTH: 1034

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 6

Met Thr Val Val Asn Pro Gln Asp Leu Gln Pr

#o Trp Val Ser Asn Phe

1               5

#                10

#                15

Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln Le

#u Ala Leu Asp Pro Ser

20

#            25

#            30

Gly Asn Gln Leu Ile Val Gly Ala Arg Asn Ty

#r Leu Phe Arg Leu Ser

35

#        40

#        45

Leu Ala Asn Val Ser Leu Leu Gln Ala Thr Gl

#u Trp Ala Ser Ser Glu

50

#    55

#    60

Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly Ly

#s Thr Glu Glu Glu Cys

65

#70

#75

#80

Gln Asn Tyr Val Arg Val Leu Ile Val Ala Gl

#y Arg Lys Val Phe Met

85

#                90

#                95

Cys Gly Thr Asn Ala Phe Ser Pro Met Cys Th

#r Ser Arg Gln Val Gly

100

#           105

#           110

Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn Gl

#y Val Ala Arg Cys Pro

115

#       120

#       125

Tyr Asp Pro Arg His Asn Ser Thr Ala Val Il

#e Ser Ser Gln Gly Glu

130

#   135

#   140

Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser Gl

#y Arg Asp Pro Ala Ile

145                 1

#50                 1

#55                 1

#60

Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu Ar

#g Thr Ala Gln Tyr Asn

165

#               170

#               175

Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Al

#a Ala Tyr Asp Ile Gly

180

#           185

#           190

Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn Al

#a Val Glu His Asp Cys

195

#       200

#       205

Gly Arg Thr Val Tyr Ser Arg Val Ala Arg Va

#l Cys Lys Asn Asp Val

210

#   215

#   220

Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Th

#r Thr Phe Met Lys Ala

225                 2

#30                 2

#35                 2

#40

Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pr

#o Phe Tyr Tyr Asn Glu

245

#               250

#               255

Leu Gln Ser Ala Phe His Leu Pro Glu Gln As

#p Leu Ile Tyr Gly Val

260

#           265

#           270

Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Se

#r Ala Val Cys Ala Phe

275

#       280

#       285

Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn Gl

#y Pro Phe Arg Tyr Gln

290

#   295

#   300

Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile Al

#a Asn Pro Ile Pro Asn

305                 3

#10                 3

#15                 3

#20

Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly Pr

#o Asn Glu Asn Leu Thr

325

#               330

#               335

Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu Ph

#e Leu Met Ser Glu Ala

340

#           345

#           350

Val Gln Pro Val Thr Pro Glu Pro Cys Val Th

#r Gln Asp Ser Val Arg

355

#       360

#       365

Phe Ser His Leu Val Val Asp Leu Val Gln Al

#a Lys Asp Thr Leu Tyr

370

#   375

#   380

His Val Leu Tyr Ile Gly Thr Glu Ser Gly Th

#r Ile Leu Lys Ala Leu

385                 3

#90                 3

#95                 4

#00

Ser Thr Ala Ser Arg Ser Leu His Gly Cys Ty

#r Leu Glu Glu Leu His

405

#               410

#               415

Val Leu Pro Pro Gly Arg Arg Glu Pro Leu Ar

#g Ser Leu Arg Ile Leu

420

#           425

#           430

His Ser Ala Arg Ala Leu Phe Val Gly Leu Ar

#g Asp Gly Val Leu Arg

435

#       440

#       445

Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg Se

#r Gln Gly Ala Cys Leu

450

#   455

#   460

Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gl

#y Lys Gln Gln Arg Cys

465                 4

#70                 4

#75                 4

#80

Ser Thr Leu Glu Asp Ser Ser Asn Met Ser Le

#u Trp Thr Gln Asn Ile

485

#               490

#               495

Thr Ala Cys Pro Val Arg Asn Val Thr Arg As

#p Gly Gly Phe Gly Pro

500

#           505

#           510

Trp Ser Pro Trp Gln Pro Cys Glu His Leu As

#p Gly Asp Asn Ser Gly

515

#       520

#       525

Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp Se

#r Pro Arg Pro Arg Cys

530

#   535

#   540

Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile Hi

#s Ile Ala Asn Cys Ser

545                 5

#50                 5

#55                 5

#60

Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser Tr

#p Ala Leu Cys Ser Thr

565

#               570

#               575

Ser Cys Gly Ile Gly Phe Gln Val Arg Gln Ar

#g Ser Cys Ser Asn Pro

580

#           585

#           590

Ala Pro Arg His Gly Gly Arg Ile Cys Val Gl

#y Lys Ser Arg Glu Glu

595

#       600

#       605

Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro Va

#l Pro Ile Phe Trp Ala

610

#   615

#   620

Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser As

#n Cys Gly Gly Gly Met

625                 6

#30                 6

#35                 6

#40

Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly As

#n Ser Cys Leu Gly Cys

645

#               650

#               655

Gly Val Glu Phe Lys Thr Cys Asn Pro Glu Gl

#y Cys Pro Glu Val Arg

660

#           665

#           670

Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Va

#l Asn Val Thr Gln Gly

675

#       680

#       685

Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Th

#r Cys Arg Ala Pro Leu

690

#   695

#   700

Ala Asp Pro His Gly Leu Gln Phe Gly Arg Ar

#g Arg Thr Glu Thr Arg

705                 7

#10                 7

#15                 7

#20

Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys As

#p Thr Asp Ala Leu Val

725

#               730

#               735

Glu Asp Leu Leu Arg Ser Gly Ser Thr Ser Pr

#o His Thr Val Ser Gly

740

#           745

#           750

Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cy

#s Ser Arg Asp Cys Glu

755

#       760

#       765

Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Th

#r Asn Pro Glu Pro Arg

770

#   775

#   780

Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Al

#a Glu Tyr Gln Asp Cys

785                 7

#90                 7

#95                 8

#00

Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Tr

#p Ser Cys Trp Thr Ser

805

#               810

#               815

Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gl

#y His Tyr Gln Arg Thr

820

#           825

#           830

Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gl

#y Glu Asp Ile Cys Leu

835

#       840

#       845

Gly Leu His Thr Glu Glu Ala Leu Cys Ala Th

#r Gln Ala Cys Pro Glu

850

#   855

#   860

Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cy

#s Thr Asp Asp Gly Ala

865                 8

#70                 8

#75                 8

#80

Gln Ser Arg Ser Arg His Cys Glu Glu Leu Le

#u Pro Gly Ser Ser Ala

885

#               890

#               895

Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cy

#s Pro Tyr Ser Glu Ile

900

#           905

#           910

Pro Gly Phe Asn Leu Ile His Leu Val Ala Th

#r Gly Ile Ser Cys Phe

915

#       920

#       925

Leu Gly Ser Gly Leu Leu Thr Leu Ala Val Ty

#r Leu Ser Cys Gln His

930

#   935

#   940

Cys Gln Arg Gln Ser Gln Glu Ser Thr Leu Va

#l His Pro Ala Thr Pro

945                 9

#50                 9

#55                 9

#60

Asn His Leu His Tyr Lys Gly Gly Gly Thr Pr

#o Lys Asn Glu Lys Tyr

965

#               970

#               975

Thr Pro Met Glu Phe Lys Thr Leu Asn Lys As

#n Asn Leu Ile Pro Asp

980

#           985

#           990

Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gln Th

#r Asn Val Tyr Thr Thr

995

#       1000

#      1005

Thr Tyr Tyr Pro Ser Pro Leu Asn Lys His Se

#r Phe Arg Pro Glu Ala

1010

#   1015

#  1020

Ser Pro Gly Gln Arg Cys Phe Pro Asn Ser

1025                1030

<210> SEQ ID NO 7

<211> LENGTH: 3237

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 7

atggtgcttg caggccccct ggctgtctcg ctgttgctgc ccagcctcac ac

#tgctggtg     60

tcccacctct ccagctccca ggatgtctcc agtgagccca gcagtgagca gc

#agctgtgc    120

gcccttagca agcaccccac cgtggccttt gaagacctgc agccgtgggt ct

#ctaacttc    180

acctaccctg gagcccggga tttctcccag ctggctttgg acccctccgg gr

#accagctc    240

atcgtgggag ccaggaacta cctcttcaga ctcagccttg ccaatgtctc tc

#ttcttcag    300

gccacagagt gggcctccag tgaggacacg cgccgctcct gccaaagcaa ag

#ggaagact    360

gaggaggagt gtcagaacta cgtgcgagtc ctgatcgtcg ccggccggaa gg

#tgttcatg    420

tgtggaacca atgccttttc ccccatgtgc accagcagac aggtggggaa cc

#tcagccgg    480

actattgaga agatcaatgg tgtggcccgc tgcccctatg acccacgcca ca

#actccaca    540

gctgtcatct cctcccaggg ggagctctat gcagccacgg tcatcgactt ct

#caggtcgg    600

gaccctgcca tctaccgcag cctgggcagt gggccaccgc ttcgcactgc cc

#aatataac    660

tccaagtggc ttaatgagcc aaacttcgtg gcagcctatg atattgggct gt

#ttgcatac    720

ttcttcctgc gggagaacgc agtggagcac gactgtggac gcaccgtgta ct

#ctcgcgtg    780

gcccgcgtgt gcaagaatga cgtggggggc cgattcctgc tggaggacac at

#ggaccaca    840

ttcatgaagg cccggctcaa ctgctcccgc ccgggcgagg tccccttcta ct

#ataacgag    900

ctgcagagtg ccttccactt gccrgagcag gacctcatct atggagtttt ca

#caaccaac    960

gtaaacagca tygcggcttc tgctgtctgc gccttcaacc tcagtgctat ct

#cccaggct   1020

ttcaatggcc catttcgcta ccaggagaac cccagggctg cctggctccc ca

#tagccaac   1080

cccatcccca atttccagtg tggcaccctg cctgagaccg gtcccaacga ga

#acctgacg   1140

gagcgcagcc tgcaggacgc gcagcgcctc ttcctgatga gcgaggccgt gc

#agccggtg   1200

acacccgagc cctgtgtcac ccaggacagc gtgcgcttct cacacctcgt gg

#tggacctg   1260

gtgcaggcta aagacacgct ctaccatgta ctctacattg gcaccgagtc gg

#gcaccatc   1320

ctgaaggcgc tgtccacggc gagccgcagc ctccacggct gctacctgga gg

#agctgcac   1380

gtgctgcccc ccgggcgccg cgagcccctg cgcagcctgc gcatcctgca ca

#gcgcccgc   1440

gcgctcttcg tggggctgag agacggcgtc ctgcgggtcc cactggagag gt

#gcgccgcc   1500

taccgcagcc agggggcatg cctgggggcc cgggacccgt actgtggctg gg

#acgggaag   1560

cagcaacgtt gcagcacact cgaggacagc tccaacatga gcctctggac cc

#agaacatc   1620

accgcctgtc ctgtgcggaa tgtgacacgg gatgggggct tcggcccatg gt

#caccatgg   1680

caaccatgtg agcacttgga tggggacaac tcaggctctt gcctgtgtcg ag

#ctcgatcc   1740

tgtgattccc ctcgaccccg ctgtgggggc cttgactgcc tggggccagc ca

#tccacatc   1800

gccaactgct ccaggaatgg ggcgtggacc ccgtggtcat cgtgggcgct gt

#gcagcacg   1860

tcctgtggca tcggcttcca ggtccgccag cgaagttgca gcaaccctgc tc

#cccgccac   1920

gggggccgca tctgcgtggg caagagccgg gaggaacggt tctgtaatga ga

#acacgcct   1980

tgcccggtgc ccatcttctg ggcttcctgg ggctcctgga gcaagtgcag ca

#gcaactgt   2040

ggagggggca tgcagtcgcg gcgtcgggcc tgcgagaacg gcaactcctg cc

#tgggctgc   2100

ggcgtggagt tcaagacgtg caaccccgag ggctgccccg aagtgcggcg ca

#acaccccc   2160

tggacgccgt ggctgcccgt gaacgtgacg cagggcgggg cacggcagga gc

#agcggttc   2220

cgcttcacct gccgcgcgcc ccttgcagac ccgcacggcc tgcagttcgg ca

#ggagaagg   2280

accgagacga ggacctgtcc cgcggacggc tccggctcct gcgacaccga cg

#ccctggtg   2340

gaggacctcc tgcgcagcgg gagcacctcc ccgcacacgg tgagcggggg ct

#gggccgcc   2400

tggggcccgt ggtcgtcctg ctcccgggac tgcgagctgg gcttccgcgt cc

#gcaagaga   2460

acgtgcacta acccggagcc ccgcaacggg ggcctgccct gcgtgggcga tg

#ctgccgag   2520

taccaggact gcaaccccca ggcttgccca gttcggggtg cttggtcctg ct

#ggacctca   2580

tggtctccat gctcagcttc ctgtggtggg ggtcactatc aacgcacccg tt

#cctgcacc   2640

agccccgcac cctccccagg tgaggacatc tgtctcgggc tgcacacgga gg

#aggcacta   2700

tgtgccacac aggcctgccc agaaggctgg tcgccctggt ctgagtggag ta

#agtgcact   2760

gacgacggag cccagagccg aagccggcac tgtgaggagc tcctcccagg gt

#ccagcgcc   2820

tgtgctggaa acagcagcca gagccgcccc tgcccctaca gcgagattcc cg

#ggttcaat   2880

ctcatccact tggtggccac gggcatctcc tgcttcttgg gctctgggct cc

#tgacccta   2940

gcagtgtacc tgtcttgcca gcactgccag cgtcagtccc aggagtccac ac

#tggtccat   3000

cctgccaccc ccaaccattt gcactacaag ggcggaggca ccccgaagaa tg

#aaaagtac   3060

acacccatgg aattcaagac cctgaacaag aataacttga tccctgatga ca

#gagccaac   3120

ttctacccat tgcagcagac caatgtgtac acgactactt actacccaag cc

#ccctgaac   3180

aaacacagct tccggcccga ggcctcacct ggacaacggt gcttccccaa ca

#gctga      3237

<210> SEQ ID NO 8

<211> LENGTH: 1078

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 8

Met Val Leu Ala Gly Pro Leu Ala Val Ser Le

#u Leu Leu Pro Ser Leu

1               5

#                10

#                15

Thr Leu Leu Val Ser His Leu Ser Ser Ser Gl

#n Asp Val Ser Ser Glu

20

#            25

#            30

Pro Ser Ser Glu Gln Gln Leu Cys Ala Leu Se

#r Lys His Pro Thr Val

35

#        40

#        45

Ala Phe Glu Asp Leu Gln Pro Trp Val Ser As

#n Phe Thr Tyr Pro Gly

50

#    55

#    60

Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pr

#o Ser Gly Asn Gln Leu

65

#70

#75

#80

Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Le

#u Ser Leu Ala Asn Val

85

#                90

#                95

Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Se

#r Glu Asp Thr Arg Arg

100

#           105

#           110

Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Gl

#u Cys Gln Asn Tyr Val

115

#       120

#       125

Arg Val Leu Ile Val Ala Gly Arg Lys Val Ph

#e Met Cys Gly Thr Asn

130

#   135

#   140

Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Va

#l Gly Asn Leu Ser Arg

145                 1

#50                 1

#55                 1

#60

Thr Ile Glu Lys Ile Asn Gly Val Ala Arg Cy

#s Pro Tyr Asp Pro Arg

165

#               170

#               175

His Asn Ser Thr Ala Val Ile Ser Ser Gln Gl

#y Glu Leu Tyr Ala Ala

180

#           185

#           190

Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Al

#a Ile Tyr Arg Ser Leu

195

#       200

#       205

Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Ty

#r Asn Ser Lys Trp Leu

210

#   215

#   220

Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Il

#e Gly Leu Phe Ala Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Leu Arg Glu Asn Ala Val Glu His As

#p Cys Gly Arg Thr Val

245

#               250

#               255

Tyr Ser Arg Val Ala Arg Val Cys Lys Asn As

#p Val Gly Gly Arg Phe

260

#           265

#           270

Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Ly

#s Ala Arg Leu Asn Cys

275

#       280

#       285

Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr As

#n Glu Leu Gln Ser Ala

290

#   295

#   300

Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gl

#y Val Phe Thr Thr Asn

305                 3

#10                 3

#15                 3

#20

Val Asn Ser Ile Ala Ala Ser Ala Val Cys Al

#a Phe Asn Leu Ser Ala

325

#               330

#               335

Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Ty

#r Gln Glu Asn Pro Arg

340

#           345

#           350

Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pr

#o Asn Phe Gln Cys Gly

355

#       360

#       365

Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Le

#u Thr Glu Arg Ser Leu

370

#   375

#   380

Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Gl

#u Ala Val Gln Pro Val

385                 3

#90                 3

#95                 4

#00

Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Va

#l Arg Phe Ser His Leu

405

#               410

#               415

Val Val Asp Leu Val Gln Ala Lys Asp Thr Le

#u Tyr His Val Leu Tyr

420

#           425

#           430

Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Al

#a Leu Ser Thr Ala Ser

435

#       440

#       445

Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Le

#u His Val Leu Pro Pro

450

#   455

#   460

Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Il

#e Leu His Ser Ala Arg

465                 4

#70                 4

#75                 4

#80

Ala Leu Phe Val Gly Leu Arg Asp Gly Val Le

#u Arg Val Pro Leu Glu

485

#               490

#               495

Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cy

#s Leu Gly Ala Arg Asp

500

#           505

#           510

Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Ar

#g Cys Ser Thr Leu Glu

515

#       520

#       525

Asp Ser Ser Asn Met Ser Leu Trp Thr Gln As

#n Ile Thr Ala Cys Pro

530

#   535

#   540

Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gl

#y Pro Trp Ser Pro Trp

545                 5

#50                 5

#55                 5

#60

Gln Pro Cys Glu His Leu Asp Gly Asp Asn Se

#r Gly Ser Cys Leu Cys

565

#               570

#               575

Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Ar

#g Cys Gly Gly Leu Asp

580

#           585

#           590

Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cy

#s Ser Arg Asn Gly Ala

595

#       600

#       605

Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Se

#r Thr Ser Cys Gly Ile

610

#   615

#   620

Gly Phe Gln Val Arg Gln Arg Ser Cys Ser As

#n Pro Ala Pro Arg His

625                 6

#30                 6

#35                 6

#40

Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Gl

#u Glu Arg Phe Cys Asn

645

#               650

#               655

Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Tr

#p Ala Ser Trp Gly Ser

660

#           665

#           670

Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gl

#y Met Gln Ser Arg Arg

675

#       680

#       685

Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gl

#y Cys Gly Val Glu Phe

690

#   695

#   700

Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Va

#l Arg Arg Asn Thr Pro

705                 7

#10                 7

#15                 7

#20

Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gl

#n Gly Gly Ala Arg Gln

725

#               730

#               735

Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pr

#o Leu Ala Asp Pro His

740

#           745

#           750

Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Th

#r Arg Thr Cys Pro Ala

755

#       760

#       765

Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Le

#u Val Glu Asp Leu Leu

770

#   775

#   780

Arg Ser Gly Ser Thr Ser Pro His Thr Val Se

#r Gly Gly Trp Ala Ala

785                 7

#90                 7

#95                 8

#00

Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cy

#s Glu Leu Gly Phe Arg

805

#               810

#               815

Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pr

#o Arg Asn Gly Gly Leu

820

#           825

#           830

Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln As

#p Cys Asn Pro Gln Ala

835

#       840

#       845

Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Th

#r Ser Trp Ser Pro Cys

850

#   855

#   860

Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Ar

#g Thr Arg Ser Cys Thr

865                 8

#70                 8

#75                 8

#80

Ser Pro Ala Pro Ser Pro Gly Glu Asp Ile Cy

#s Leu Gly Leu His Thr

885

#               890

#               895

Glu Glu Ala Leu Cys Ala Thr Gln Ala Cys Pr

#o Glu Gly Trp Ser Pro

900

#           905

#           910

Trp Ser Glu Trp Ser Lys Cys Thr Asp Asp Gl

#y Ala Gln Ser Arg Ser

915

#       920

#       925

Arg His Cys Glu Glu Leu Leu Pro Gly Ser Se

#r Ala Cys Ala Gly Asn

930

#   935

#   940

Ser Ser Gln Ser Arg Pro Cys Pro Tyr Ser Gl

#u Ile Pro Gly Phe Asn

945                 9

#50                 9

#55                 9

#60

Leu Ile His Leu Val Ala Thr Gly Ile Ser Cy

#s Phe Leu Gly Ser Gly

965

#               970

#               975

Leu Leu Thr Leu Ala Val Tyr Leu Ser Cys Gl

#n His Cys Gln Arg Gln

980

#           985

#           990

Ser Gln Glu Ser Thr Leu Val His Pro Ala Th

#r Pro Asn His Leu His

995

#       1000

#      1005

Tyr Lys Gly Gly Gly Thr Pro Lys Asn Glu Ly

#s Tyr Thr Pro Met Glu

1010

#   1015

#  1020

Phe Lys Thr Leu Asn Lys Asn Asn Leu Ile Pr

#o Asp Asp Arg Ala Asn

1025                1030

#                1035

#               1040

Phe Tyr Pro Leu Gln Gln Thr Asn Val Tyr Th

#r Thr Thr Tyr Tyr Pro

1045

#               1050

#              1055

Ser Pro Leu Asn Lys His Ser Phe Arg Pro Gl

#u Ala Ser Pro Gly Gln

1060

#           1065

#          1070

Arg Cys Phe Pro Asn Ser

1075

<210> SEQ ID NO 9

<211> LENGTH: 3456

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 9

atgccctgtg gcttcagtcc gtctcctgtt gcccaccacc tcgtccctgg gc

#cgcctgat     60

accccagccc aacagctaag gtgtggatgg acagtagggg gctggcttct ct

#cactggtc    120

aggggtcttc tcccctgtct gcctcccgga gctaggactg cagaggggcc ta

#tcatggtg    180

cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tcacactgct gg

#tgtcccac    240

ctctccagct cccaggatgt ctccagtgag cccagcagtg agcagcagct gt

#gcgccctt    300

agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gggtctctaa ct

#tcacctac    360

cctggagccc gggatttctc ccagctggct ttggacccct ccgggracca gc

#tcatcgtg    420

ggagccagga actacctctt cagactcagc cttgccaatg tctctcttct tc

#aggccaca    480

gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gcaaagggaa ga

#ctgaggag    540

gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc ggaaggtgtt ca

#tgtgtgga    600

accaatgcct tttcccccat gtgcaccagc agacaggtgg ggaacctcag cc

#ggactatt    660

gagaagatca atggtgtggc ccgctgcccc tatgacccac gccacaactc ca

#cagctgtc    720

atctcctccc agggggagct ctatgcagcc acggtcatcg acttctcagg tc

#gggaccct    780

gccatctacc gcagcctggg cagtgggcca ccgcttcgca ctgcccaata ta

#actccaag    840

tggcttaatg agccaaactt cgtggcagcc tatgatattg ggctgtttgc at

#acttcttc    900

ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tgtactctcg cg

#tggcccgc    960

gtgtgcaaga atgacgtggg gggccgattc ctgctggagg acacatggac ca

#cattcatg   1020

aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tctactataa cg

#agctgcag   1080

agtgccttcc acttgccrga gcaggacctc atctatggag ttttcacaac ca

#acgtaaac   1140

agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ctatctccca gg

#ctttcaat   1200

ggcccatttc gctaccagga gaaccccagg gctgcctggc tccccatagc ca

#accccatc   1260

cccaatttcc agtgtggcac cctgcctgag accggtccca acgagaacct ga

#cggagcgc   1320

agcctgcagg acgcgcagcg cctcttcctg atgagcgagg ccgtgcagcc gg

#tgacaccc   1380

gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tcgtggtgga cc

#tggtgcag   1440

gctaaagaca cgctctacca tgtactctac attggcaccg agtcgggcac ca

#tcctgaag   1500

gcgctgtcca cggcgagccg cagcctccac ggctgctacc tggaggagct gc

#acgtgctg   1560

ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tgcacagcgc cc

#gcgcgctc   1620

ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg agaggtgcgc cg

#cctaccgc   1680

agccaggggg catgcctggg ggcccgggac ccgtactgtg gctgggacgg ga

#agcagcaa   1740

cgttgcagca cactcgagga cagctccaac atgagcctct ggacccagaa ca

#tcaccgcc   1800

tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc catggtcacc at

#ggcaacca   1860

tgtgagcact tggatgggga caactcaggc tcttgcctgt gtcgagctcg at

#cctgtgat   1920

tcccctcgac cccgctgtgg gggccttgac tgcctggggc cagccatcca ca

#tcgccaac   1980

tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cgctgtgcag ca

#cgtcctgt   2040

ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ctgctccccg cc

#acgggggc   2100

cgcatctgcg tgggcaagag ccgggaggaa cggttctgta atgagaacac gc

#cttgcccg   2160

gtgcccatct tctgggcttc ctggggctcc tggagcaagt gcagcagcaa ct

#gtggaggg   2220

ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cctgcctggg ct

#gcggcgtg   2280

gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc ggcgcaacac cc

#cctggacg   2340

ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc aggagcagcg gt

#tccgcttc   2400

acctgccgcg cgccccttgc agacccgcac ggcctgcagt tcggcaggag aa

#ggaccgag   2460

acgaggacct gtcccgcgga cggctccggc tcctgcgaca ccgacgccct gg

#tggaggac   2520

ctcctgcgca gcgggagcac ctccccgcac acggtgagcg ggggctgggc cg

#cctggggc   2580

ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gcgtccgcaa ga

#gaacgtgc   2640

actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gcgatgctgc cg

#agtaccag   2700

gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cctgctggac ct

#catggtct   2760

ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cccgttcctg ca

#ccagcccc   2820

gcaccctccc caggtgagga catctgtctc gggctgcaca cggaggaggc ac

#tatgtgcc   2880

acacaggcct gcccagaagg ctggtcgccc tggtctgagt ggagtaagtg ca

#ctgacgac   2940

ggagcccaga gccgaagccg gcactgtgag gagctcctcc cagggtccag cg

#cctgtgct   3000

ggaaacagca gccagagccg cccctgcccc tacagcgaga ttcccgtcat cc

#tgccagcc   3060

tccagcatgg aggaggccac cggctgtgca gggttcaatc tcatccactt gg

#tggccacg   3120

ggcatctcct gcttcttggg ctctgggctc ctgaccctag cagtgtacct gt

#cttgccag   3180

cactgccagc gtcagtccca ggagtccaca ctggtccatc ctgccacccc ca

#accatttg   3240

cactacaagg gcggaggcac cccgaagaat gaaaagtaca cacccatgga at

#tcaagacc   3300

ctgaacaaga ataacttgat ccctgatgac agagccaact tctacccatt gc

#agcagacc   3360

aatgtgtaca cgactactta ctacccaagc cccctgaaca aacacagctt cc

#ggcccgag   3420

gcctcacctg gacaacggtg cttccccaac agctga

#

#     3456

<210> SEQ ID NO 10

<211> LENGTH: 1151

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 10

Met Pro Cys Gly Phe Ser Pro Ser Pro Val Al

#a His His Leu Val Pro

1               5

#                10

#                15

Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Ar

#g Cys Gly Trp Thr Val

20

#            25

#            30

Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Le

#u Leu Pro Cys Leu Pro

35

#        40

#        45

Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Me

#t Val Leu Ala Gly Pro

50

#    55

#    60

Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Th

#r Leu Leu Val Ser His

65

#70

#75

#80

Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pr

#o Ser Ser Glu Gln Gln

85

#                90

#                95

Leu Cys Ala Leu Ser Lys His Pro Thr Val Al

#a Phe Glu Asp Leu Gln

100

#           105

#           110

Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Al

#a Arg Asp Phe Ser Gln

115

#       120

#       125

Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Il

#e Val Gly Ala Arg Asn

130

#   135

#   140

Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Se

#r Leu Leu Gln Ala Thr

145                 1

#50                 1

#55                 1

#60

Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Se

#r Cys Gln Ser Lys Gly

165

#               170

#               175

Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Ar

#g Val Leu Ile Val Ala

180

#           185

#           190

Gly Arg Lys Val Phe Met Cys Gly Thr Asn Al

#a Phe Ser Pro Met Cys

195

#       200

#       205

Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Th

#r Ile Glu Lys Ile Asn

210

#   215

#   220

Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg Hi

#s Asn Ser Thr Ala Val

225                 2

#30                 2

#35                 2

#40

Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Th

#r Val Ile Asp Phe Ser

245

#               250

#               255

Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gl

#y Ser Gly Pro Pro Leu

260

#           265

#           270

Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu As

#n Glu Pro Asn Phe Val

275

#       280

#       285

Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Ph

#e Phe Leu Arg Glu Asn

290

#   295

#   300

Ala Val Glu His Asp Cys Gly Arg Thr Val Ty

#r Ser Arg Val Ala Arg

305                 3

#10                 3

#15                 3

#20

Val Cys Lys Asn Asp Val Gly Gly Arg Phe Le

#u Leu Glu Asp Thr Trp

325

#               330

#               335

Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Se

#r Arg Pro Gly Glu Val

340

#           345

#           350

Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Ph

#e His Leu Pro Glu Gln

355

#       360

#       365

Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Va

#l Asn Ser Ile Ala Ala

370

#   375

#   380

Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Il

#e Ser Gln Ala Phe Asn

385                 3

#90                 3

#95                 4

#00

Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Al

#a Ala Trp Leu Pro Ile

405

#               410

#               415

Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Th

#r Leu Pro Glu Thr Gly

420

#           425

#           430

Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gl

#n Asp Ala Gln Arg Leu

435

#       440

#       445

Phe Leu Met Ser Glu Ala Val Gln Pro Val Th

#r Pro Glu Pro Cys Val

450

#   455

#   460

Thr Gln Asp Ser Val Arg Phe Ser His Leu Va

#l Val Asp Leu Val Gln

465                 4

#70                 4

#75                 4

#80

Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Il

#e Gly Thr Glu Ser Gly

485

#               490

#               495

Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Ar

#g Ser Leu His Gly Cys

500

#           505

#           510

Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gl

#y Arg Arg Glu Pro Leu

515

#       520

#       525

Arg Ser Leu Arg Ile Leu His Ser Ala Arg Al

#a Leu Phe Val Gly Leu

530

#   535

#   540

Arg Asp Gly Val Leu Arg Val Pro Leu Glu Ar

#g Cys Ala Ala Tyr Arg

545                 5

#50                 5

#55                 5

#60

Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

565

#               570

#               575

Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu As

#p Ser Ser Asn Met Ser

580

#           585

#           590

Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Va

#l Arg Asn Val Thr Arg

595

#       600

#       605

Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gl

#n Pro Cys Glu His Leu

610

#   615

#   620

Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Ar

#g Ala Arg Ser Cys Asp

625                 6

#30                 6

#35                 6

#40

Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cy

#s Leu Gly Pro Ala Ile

645

#               650

#               655

His Ile Ala Asn Cys Ser Arg Asn Gly Ala Tr

#p Thr Pro Trp Ser Ser

660

#           665

#           670

Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gl

#y Phe Gln Val Arg Gln

675

#       680

#       685

Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gl

#y Gly Arg Ile Cys Val

690

#   695

#   700

Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Gl

#u Asn Thr Pro Cys Pro

705                 7

#10                 7

#15                 7

#20

Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Tr

#p Ser Lys Cys Ser Ser

725

#               730

#               735

Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Ar

#g Ala Cys Glu Asn Gly

740

#           745

#           750

Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Ly

#s Thr Cys Asn Pro Glu

755

#       760

#       765

Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Tr

#p Thr Pro Trp Leu Pro

770

#   775

#   780

Val Asn Val Thr Gln Gly Gly Ala Arg Gln Gl

#u Gln Arg Phe Arg Phe

785                 7

#90                 7

#95                 8

#00

Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gl

#y Leu Gln Phe Gly Arg

805

#               810

#               815

Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala As

#p Gly Ser Gly Ser Cys

820

#           825

#           830

Asp Thr Asp Ala Leu Val Glu Asp Leu Leu Ar

#g Ser Gly Ser Thr Ser

835

#       840

#       845

Pro His Thr Val Ser Gly Gly Trp Ala Ala Tr

#p Gly Pro Trp Ser Ser

850

#   855

#   860

Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Va

#l Arg Lys Arg Thr Cys

865                 8

#70                 8

#75                 8

#80

Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pr

#o Cys Val Gly Asp Ala

885

#               890

#               895

Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cy

#s Pro Val Arg Gly Ala

900

#           905

#           910

Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Se

#r Ala Ser Cys Gly Gly

915

#       920

#       925

Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Se

#r Pro Ala Pro Ser Pro

930

#   935

#   940

Gly Glu Asp Ile Cys Leu Gly Leu His Thr Gl

#u Glu Ala Leu Cys Ala

945                 9

#50                 9

#55                 9

#60

Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Tr

#p Ser Glu Trp Ser Lys

965

#               970

#               975

Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Ar

#g His Cys Glu Glu Leu

980

#           985

#           990

Leu Pro Gly Ser Ser Ala Cys Ala Gly Asn Se

#r Ser Gln Ser Arg Pro

995

#       1000

#      1005

Cys Pro Tyr Ser Glu Ile Pro Val Ile Leu Pr

#o Ala Ser Ser Met Glu

1010

#   1015

#  1020

Glu Ala Thr Gly Cys Ala Gly Phe Asn Leu Il

#e His Leu Val Ala Thr

1025                1030

#                1035

#               1040

Gly Ile Ser Cys Phe Leu Gly Ser Gly Leu Le

#u Thr Leu Ala Val Tyr

1045

#               1050

#              1055

Leu Ser Cys Gln His Cys Gln Arg Gln Ser Gl

#n Glu Ser Thr Leu Val

1060

#           1065

#          1070

His Pro Ala Thr Pro Asn His Leu His Tyr Ly

#s Gly Gly Gly Thr Pro

1075

#       1080

#      1085

Lys Asn Glu Lys Tyr Thr Pro Met Glu Phe Ly

#s Thr Leu Asn Lys Asn

1090

#   1095

#  1100

Asn Leu Ile Pro Asp Asp Arg Ala Asn Phe Ty

#r Pro Leu Gln Gln Thr

1105                1110

#                1115

#               1120

Asn Val Tyr Thr Thr Thr Tyr Tyr Pro Ser Pr

#o Leu Asn Lys His Ser

1125

#               1130

#              1135

Phe Arg Pro Glu Ala Ser Pro Gly Gln Arg Cy

#s Phe Pro Asn Ser

1140

#           1145

#          1150

<210> SEQ ID NO 11

<211> LENGTH: 3411

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 11

atgccctgtg gcttcagtcc gtctcctgtt gcccaccacc tcgtccctgg gc

#cgcctgat     60

accccagccc aacagctaag gtgtggatgg acagtagggg gctggcttct ct

#cactggtc    120

aggggtcttc tcccctgtct gcctcccgga gctaggactg cagaggggcc ta

#tcatggtg    180

cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tcacactgct gg

#tgtcccac    240

ctctccagct cccaggatgt ctccagtgag cccagcagtg agcagcagct gt

#gcgccctt    300

agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gggtctctaa ct

#tcacctac    360

cctggagccc gggatttctc ccagctggct ttggacccct ccgggracca gc

#tcatcgtg    420

ggagccagga actacctctt cagactcagc cttgccaatg tctctcttct tc

#aggccaca    480

gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gcaaagggaa ga

#ctgaggag    540

gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc ggaaggtgtt ca

#tgtgtgga    600

accaatgcct tttcccccat gtgcaccagc agacaggtgg ggaacctcag cc

#ggactatt    660

gagaagatca atggtgtggc ccgctgcccc tatgacccac gccacaactc ca

#cagctgtc    720

atctcctccc agggggagct ctatgcagcc acggtcatcg acttctcagg tc

#gggaccct    780

gccatctacc gcagcctggg cagtgggcca ccgcttcgca ctgcccaata ta

#actccaag    840

tggcttaatg agccaaactt cgtggcagcc tatgatattg ggctgtttgc at

#acttcttc    900

ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tgtactctcg cg

#tggcccgc    960

gtgtgcaaga atgacgtggg gggccgattc ctgctggagg acacatggac ca

#cattcatg   1020

aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tctactataa cg

#agctgcag   1080

agtgccttcc acttgccrga gcaggacctc atctatggag ttttcacaac ca

#acgtaaac   1140

agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ctatctccca gg

#ctttcaat   1200

ggcccatttc gctaccagga gaaccccagg gctgcctggc tccccatagc ca

#accccatc   1260

cccaatttcc agtgtggcac cctgcctgag accggtccca acgagaacct ga

#cggagcgc   1320

agcctgcagg acgcgcagcg cctcttcctg atgagcgagg ccgtgcagcc gg

#tgacaccc   1380

gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tcgtggtgga cc

#tggtgcag   1440

gctaaagaca cgctctacca tgtactctac attggcaccg agtcgggcac ca

#tcctgaag   1500

gcgctgtcca cggcgagccg cagcctccac ggctgctacc tggaggagct gc

#acgtgctg   1560

ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tgcacagcgc cc

#gcgcgctc   1620

ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg agaggtgcgc cg

#cctaccgc   1680

agccaggggg catgcctggg ggcccgggac ccgtactgtg gctgggacgg ga

#agcagcaa   1740

cgttgcagca cactcgagga cagctccaac atgagcctct ggacccagaa ca

#tcaccgcc   1800

tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc catggtcacc at

#ggcaacca   1860

tgtgagcact tggatgggga caactcaggc tcttgcctgt gtcgagctcg at

#cctgtgat   1920

tcccctcgac cccgctgtgg gggccttgac tgcctggggc cagccatcca ca

#tcgccaac   1980

tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cgctgtgcag ca

#cgtcctgt   2040

ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ctgctccccg cc

#acgggggc   2100

cgcatctgcg tgggcaagag ccgggaggaa cggttctgta atgagaacac gc

#cttgcccg   2160

gtgcccatct tctgggcttc ctggggctcc tggagcaagt gcagcagcaa ct

#gtggaggg   2220

ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cctgcctggg ct

#gcggcgtg   2280

gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc ggcgcaacac cc

#cctggacg   2340

ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc aggagcagcg gt

#tccgcttc   2400

acctgccgcg cgccccttgc agacccgcac ggcctgcagt tcggcaggag aa

#ggaccgag   2460

acgaggacct gtcccgcgga cggctccggc tcctgcgaca ccgacgccct gg

#tggaggac   2520

ctcctgcgca gcgggagcac ctccccgcac acggtgagcg ggggctgggc cg

#cctggggc   2580

ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gcgtccgcaa ga

#gaacgtgc   2640

actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gcgatgctgc cg

#agtaccag   2700

gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cctgctggac ct

#catggtct   2760

ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cccgttcctg ca

#ccagcccc   2820

gcaccctccc caggtgagga catctgtctc gggctgcaca cggaggaggc ac

#tatgtgcc   2880

acacaggcct gcccagaagg ctggtcgccc tggtctgagt ggagtaagtg ca

#ctgacgac   2940

ggagcccaga gccgaagccg gcactgtgag gagctcctcc cagggtccag cg

#cctgtgct   3000

ggaaacagca gccagagccg cccctgcccc tacagcgaga ttcccgggtt ca

#atctcatc   3060

cacttggtgg ccacgggcat ctcctgcttc ttgggctctg ggctcctgac cc

#tagcagtg   3120

tacctgtctt gccagcactg ccagcgtcag tcccaggagt ccacactggt cc

#atcctgcc   3180

acccccaacc atttgcacta caagggcgga ggcaccccga agaatgaaaa gt

#acacaccc   3240

atggaattca agaccctgaa caagaataac ttgatccctg atgacagagc ca

#acttctac   3300

ccattgcagc agaccaatgt gtacacgact acttactacc caagccccct ga

#acaaacac   3360

agcttccggc ccgaggcctc acctggacaa cggtgcttcc ccaacagctg a

#           3411

<210> SEQ ID NO 12

<211> LENGTH: 1136

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 12

Met Pro Cys Gly Phe Ser Pro Ser Pro Val Al

#a His His Leu Val Pro

1               5

#                10

#                15

Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Ar

#g Cys Gly Trp Thr Val

20

#            25

#            30

Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Le

#u Leu Pro Cys Leu Pro

35

#        40

#        45

Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Me

#t Val Leu Ala Gly Pro

50

#    55

#    60

Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Th

#r Leu Leu Val Ser His

65

#70

#75

#80

Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pr

#o Ser Ser Glu Gln Gln

85

#                90

#                95

Leu Cys Ala Leu Ser Lys His Pro Thr Val Al

#a Phe Glu Asp Leu Gln

100

#           105

#           110

Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Al

#a Arg Asp Phe Ser Gln

115

#       120

#       125

Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Il

#e Val Gly Ala Arg Asn

130

#   135

#   140

Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Se

#r Leu Leu Gln Ala Thr

145                 1

#50                 1

#55                 1

#60

Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Se

#r Cys Gln Ser Lys Gly

165

#               170

#               175

Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Ar

#g Val Leu Ile Val Ala

180

#           185

#           190

Gly Arg Lys Val Phe Met Cys Gly Thr Asn Al

#a Phe Ser Pro Met Cys

195

#       200

#       205

Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Th

#r Ile Glu Lys Ile Asn

210

#   215

#   220

Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg Hi

#s Asn Ser Thr Ala Val

225                 2

#30                 2

#35                 2

#40

Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Th

#r Val Ile Asp Phe Ser

245

#               250

#               255

Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gl

#y Ser Gly Pro Pro Leu

260

#           265

#           270

Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu As

#n Glu Pro Asn Phe Val

275

#       280

#       285

Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Ph

#e Phe Leu Arg Glu Asn

290

#   295

#   300

Ala Val Glu His Asp Cys Gly Arg Thr Val Ty

#r Ser Arg Val Ala Arg

305                 3

#10                 3

#15                 3

#20

Val Cys Lys Asn Asp Val Gly Gly Arg Phe Le

#u Leu Glu Asp Thr Trp

325

#               330

#               335

Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Se

#r Arg Pro Gly Glu Val

340

#           345

#           350

Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Ph

#e His Leu Pro Glu Gln

355

#       360

#       365

Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Va

#l Asn Ser Ile Ala Ala

370

#   375

#   380

Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Il

#e Ser Gln Ala Phe Asn

385                 3

#90                 3

#95                 4

#00

Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Al

#a Ala Trp Leu Pro Ile

405

#               410

#               415

Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Th

#r Leu Pro Glu Thr Gly

420

#           425

#           430

Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gl

#n Asp Ala Gln Arg Leu

435

#       440

#       445

Phe Leu Met Ser Glu Ala Val Gln Pro Val Th

#r Pro Glu Pro Cys Val

450

#   455

#   460

Thr Gln Asp Ser Val Arg Phe Ser His Leu Va

#l Val Asp Leu Val Gln

465                 4

#70                 4

#75                 4

#80

Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Il

#e Gly Thr Glu Ser Gly

485

#               490

#               495

Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Ar

#g Ser Leu His Gly Cys

500

#           505

#           510

Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gl

#y Arg Arg Glu Pro Leu

515

#       520

#       525

Arg Ser Leu Arg Ile Leu His Ser Ala Arg Al

#a Leu Phe Val Gly Leu

530

#   535

#   540

Arg Asp Gly Val Leu Arg Val Pro Leu Glu Ar

#g Cys Ala Ala Tyr Arg

545                 5

#50                 5

#55                 5

#60

Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

565

#               570

#               575

Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu As

#p Ser Ser Asn Met Ser

580

#           585

#           590

Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Va

#l Arg Asn Val Thr Arg

595

#       600

#       605

Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gl

#n Pro Cys Glu His Leu

610

#   615

#   620

Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Ar

#g Ala Arg Ser Cys Asp

625                 6

#30                 6

#35                 6

#40

Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cy

#s Leu Gly Pro Ala Ile

645

#               650

#               655

His Ile Ala Asn Cys Ser Arg Asn Gly Ala Tr

#p Thr Pro Trp Ser Ser

660

#           665

#           670

Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gl

#y Phe Gln Val Arg Gln

675

#       680

#       685

Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gl

#y Gly Arg Ile Cys Val

690

#   695

#   700

Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Gl

#u Asn Thr Pro Cys Pro

705                 7

#10                 7

#15                 7

#20

Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Tr

#p Ser Lys Cys Ser Ser

725

#               730

#               735

Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Ar

#g Ala Cys Glu Asn Gly

740

#           745

#           750

Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Ly

#s Thr Cys Asn Pro Glu

755

#       760

#       765

Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Tr

#p Thr Pro Trp Leu Pro

770

#   775

#   780

Val Asn Val Thr Gln Gly Gly Ala Arg Gln Gl

#u Gln Arg Phe Arg Phe

785                 7

#90                 7

#95                 8

#00

Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gl

#y Leu Gln Phe Gly Arg

805

#               810

#               815

Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala As

#p Gly Ser Gly Ser Cys

820

#           825

#           830

Asp Thr Asp Ala Leu Val Glu Asp Leu Leu Ar

#g Ser Gly Ser Thr Ser

835

#       840

#       845

Pro His Thr Val Ser Gly Gly Trp Ala Ala Tr

#p Gly Pro Trp Ser Ser

850

#   855

#   860

Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Va

#l Arg Lys Arg Thr Cys

865                 8

#70                 8

#75                 8

#80

Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pr

#o Cys Val Gly Asp Ala

885

#               890

#               895

Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cy

#s Pro Val Arg Gly Ala

900

#           905

#           910

Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Se

#r Ala Ser Cys Gly Gly

915

#       920

#       925

Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Se

#r Pro Ala Pro Ser Pro

930

#   935

#   940

Gly Glu Asp Ile Cys Leu Gly Leu His Thr Gl

#u Glu Ala Leu Cys Ala

945                 9

#50                 9

#55                 9

#60

Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Tr

#p Ser Glu Trp Ser Lys

965

#               970

#               975

Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Ar

#g His Cys Glu Glu Leu

980

#           985

#           990

Leu Pro Gly Ser Ser Ala Cys Ala Gly Asn Se

#r Ser Gln Ser Arg Pro

995

#       1000

#      1005

Cys Pro Tyr Ser Glu Ile Pro Gly Phe Asn Le

#u Ile His Leu Val Ala

1010

#   1015

#  1020

Thr Gly Ile Ser Cys Phe Leu Gly Ser Gly Le

#u Leu Thr Leu Ala Val

1025                1030

#                1035

#               1040

Tyr Leu Ser Cys Gln His Cys Gln Arg Gln Se

#r Gln Glu Ser Thr Leu

1045

#               1050

#              1055

Val His Pro Ala Thr Pro Asn His Leu His Ty

#r Lys Gly Gly Gly Thr

1060

#           1065

#          1070

Pro Lys Asn Glu Lys Tyr Thr Pro Met Glu Ph

#e Lys Thr Leu Asn Lys

1075

#       1080

#      1085

Asn Asn Leu Ile Pro Asp Asp Arg Ala Asn Ph

#e Tyr Pro Leu Gln Gln

1090

#   1095

#  1100

Thr Asn Val Tyr Thr Thr Thr Tyr Tyr Pro Se

#r Pro Leu Asn Lys His

1105                1110

#                1115

#               1120

Ser Phe Arg Pro Glu Ala Ser Pro Gly Gln Ar

#g Cys Phe Pro Asn Ser

1125

#               1130

#              1135

<210> SEQ ID NO 13

<211> LENGTH: 2865

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 13

atgtgtggaa ccaatgcctt ttcccccatg tgcaccagca gacaggtggg ga

#acctcagc     60

cggactattg agaagatcaa tggtgtggcc cgctgcccct atgacccacg cc

#acaactcc    120

acagctgtca tctcctccca gggggagctc tatgcagcca cggtcatcga ct

#tctcaggt    180

cgggaccctg ccatctaccg cagcctgggc agtgggccac cgcttcgcac tg

#cccaatat    240

aactccaagt ggcttaatga gccaaacttc gtggcagcct atgatattgg gc

#tgtttgca    300

tacttcttcc tgcgggagaa cgcagtggag cacgactgtg gacgcaccgt gt

#actctcgc    360

gtggcccgcg tgtgcaagaa tgacgtgggg ggccgattcc tgctggagga ca

#catggacc    420

acattcatga aggcccggct caactgctcc cgcccgggcg aggtcccctt ct

#actataac    480

gagctgcaga gtgccttcca cttgccrgag caggacctca tctatggagt tt

#tcacaacc    540

aacgtaaaca gcatygcggc ttctgctgtc tgcgccttca acctcagtgc ta

#tctcccag    600

gctttcaatg gcccatttcg ctaccaggag aaccccaggg ctgcctggct cc

#ccatagcc    660

aaccccatcc ccaatttcca gtgtggcacc ctgcctgaga ccggtcccaa cg

#agaacctg    720

acggagcgca gcctgcagga cgcgcagcgc ctcttcctga tgagcgaggc cg

#tgcagccg    780

gtgacacccg agccctgtgt cacccaggac agcgtgcgct tctcacacct cg

#tggtggac    840

ctggtgcagg ctaaagacac gctctaccat gtactctaca ttggcaccga gt

#cgggcacc    900

atcctgaagg cgctgtccac ggcgagccgc agcctccacg gctgctacct gg

#aggagctg    960

cacgtgctgc cccccgggcg ccgcgagccc ctgcgcagcc tgcgcatcct gc

#acagcgcc   1020

cgcgcgctct tcgtggggct gagagacggc gtcctgcggg tcccactgga ga

#ggtgcgcc   1080

gcctaccgca gccagggggc atgcctgggg gcccgggacc cgtactgtgg ct

#gggacggg   1140

aagcagcaac gttgcagcac actcgaggac agctccaaca tgagcctctg ga

#cccagaac   1200

atcaccgcct gtcctgtgcg gaatgtgaca cgggatgggg gcttcggccc at

#ggtcacca   1260

tggcaaccat gtgagcactt ggatggggac aactcaggct cttgcctgtg tc

#gagctcga   1320

tcctgtgatt cccctcgacc ccgctgtggg ggccttgact gcctggggcc ag

#ccatccac   1380

atcgccaact gctccaggaa tggggcgtgg accccgtggt catcgtgggc gc

#tgtgcagc   1440

acgtcctgtg gcatcggctt ccaggtccgc cagcgaagtt gcagcaaccc tg

#ctccccgc   1500

cacgggggcc gcatctgcgt gggcaagagc cgggaggaac ggttctgtaa tg

#agaacacg   1560

ccttgcccgg tgcccatctt ctgggcttcc tggggctcct ggagcaagtg ca

#gcagcaac   1620

tgtggagggg gcatgcagtc gcggcgtcgg gcctgcgaga acggcaactc ct

#gcctgggc   1680

tgcggcgtgg agttcaagac gtgcaacccc gagggctgcc ccgaagtgcg gc

#gcaacacc   1740

ccctggacgc cgtggctgcc cgtgaacgtg acgcagggcg gggcacggca gg

#agcagcgg   1800

ttccgcttca cctgccgcgc gccccttgca gacccgcacg gcctgcagtt cg

#gcaggaga   1860

aggaccgaga cgaggacctg tcccgcggac ggctccggct cctgcgacac cg

#acgccctg   1920

gtggaggacc tcctgcgcag cgggagcacc tccccgcaca cggtgagcgg gg

#gctgggcc   1980

gcctggggcc cgtggtcgtc ctgctcccgg gactgcgagc tgggcttccg cg

#tccgcaag   2040

agaacgtgca ctaacccgga gccccgcaac gggggcctgc cctgcgtggg cg

#atgctgcc   2100

gagtaccagg actgcaaccc ccaggcttgc ccagttcggg gtgcttggtc ct

#gctggacc   2160

tcatggtctc catgctcagc ttcctgtggt gggggtcact atcaacgcac cc

#gttcctgc   2220

accagccccg caccctcccc aggtgaggac atctgtctcg ggctgcacac gg

#aggaggca   2280

ctatgtgcca cacaggcctg cccagaaggc tggtcgccct ggtctgagtg ga

#gtaagtgc   2340

actgacgacg gagcccagag ccgaagccgg cactgtgagg agctcctccc ag

#ggtccagc   2400

gcctgtgctg gaaacagcag ccagagccgc ccctgcccct acagcgagat tc

#ccgtcatc   2460

ctgccagcct ccagcatgga ggaggccacc ggctgtgcag ggttcaatct ca

#tccacttg   2520

gtggccacgg gcatctcctg cttcttgggc tctgggctcc tgaccctagc ag

#tgtacctg   2580

tcttgccagc actgccagcg tcagtcccag gagtccacac tggtccatcc tg

#ccaccccc   2640

aaccatttgc actacaaggg cggaggcacc ccgaagaatg aaaagtacac ac

#ccatggaa   2700

ttcaagaccc tgaacaagaa taacttgatc cctgatgaca gagccaactt ct

#acccattg   2760

cagcagacca atgtgtacac gactacttac tacccaagcc ccctgaacaa ac

#acagcttc   2820

cggcccgagg cctcacctgg acaacggtgc ttccccaaca gctga

#                2865

<210> SEQ ID NO 14

<211> LENGTH: 954

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 14

Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cy

#s Thr Ser Arg Gln Val

1               5

#                10

#                15

Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile As

#n Gly Val Ala Arg Cys

20

#            25

#            30

Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Va

#l Ile Ser Ser Gln Gly

35

#        40

#        45

Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Se

#r Gly Arg Asp Pro Ala

50

#    55

#    60

Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Le

#u Arg Thr Ala Gln Tyr

65

#70

#75

#80

Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Va

#l Ala Ala Tyr Asp Ile

85

#                90

#                95

Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu As

#n Ala Val Glu His Asp

100

#           105

#           110

Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Ar

#g Val Cys Lys Asn Asp

115

#       120

#       125

Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Tr

#p Thr Thr Phe Met Lys

130

#   135

#   140

Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Va

#l Pro Phe Tyr Tyr Asn

145                 1

#50                 1

#55                 1

#60

Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gl

#n Asp Leu Ile Tyr Gly

165

#               170

#               175

Val Phe Thr Thr Asn Val Asn Ser Ile Ala Al

#a Ser Ala Val Cys Ala

180

#           185

#           190

Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe As

#n Gly Pro Phe Arg Tyr

195

#       200

#       205

Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Il

#e Ala Asn Pro Ile Pro

210

#   215

#   220

Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gl

#y Pro Asn Glu Asn Leu

225                 2

#30                 2

#35                 2

#40

Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Le

#u Phe Leu Met Ser Glu

245

#               250

#               255

Ala Val Gln Pro Val Thr Pro Glu Pro Cys Va

#l Thr Gln Asp Ser Val

260

#           265

#           270

Arg Phe Ser His Leu Val Val Asp Leu Val Gl

#n Ala Lys Asp Thr Leu

275

#       280

#       285

Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gl

#y Thr Ile Leu Lys Ala

290

#   295

#   300

Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cy

#s Tyr Leu Glu Glu Leu

305                 3

#10                 3

#15                 3

#20

His Val Leu Pro Pro Gly Arg Arg Glu Pro Le

#u Arg Ser Leu Arg Ile

325

#               330

#               335

Leu His Ser Ala Arg Ala Leu Phe Val Gly Le

#u Arg Asp Gly Val Leu

340

#           345

#           350

Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Ar

#g Ser Gln Gly Ala Cys

355

#       360

#       365

Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp As

#p Gly Lys Gln Gln Arg

370

#   375

#   380

Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Se

#r Leu Trp Thr Gln Asn

385                 3

#90                 3

#95                 4

#00

Ile Thr Ala Cys Pro Val Arg Asn Val Thr Ar

#g Asp Gly Gly Phe Gly

405

#               410

#               415

Pro Trp Ser Pro Trp Gln Pro Cys Glu His Le

#u Asp Gly Asp Asn Ser

420

#           425

#           430

Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys As

#p Ser Pro Arg Pro Arg

435

#       440

#       445

Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Il

#e His Ile Ala Asn Cys

450

#   455

#   460

Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Se

#r Trp Ala Leu Cys Ser

465                 4

#70                 4

#75                 4

#80

Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gl

#n Arg Ser Cys Ser Asn

485

#               490

#               495

Pro Ala Pro Arg His Gly Gly Arg Ile Cys Va

#l Gly Lys Ser Arg Glu

500

#           505

#           510

Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pr

#o Val Pro Ile Phe Trp

515

#       520

#       525

Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Se

#r Asn Cys Gly Gly Gly

530

#   535

#   540

Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gl

#y Asn Ser Cys Leu Gly

545                 5

#50                 5

#55                 5

#60

Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Gl

#u Gly Cys Pro Glu Val

565

#               570

#               575

Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pr

#o Val Asn Val Thr Gln

580

#           585

#           590

Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Ph

#e Thr Cys Arg Ala Pro

595

#       600

#       605

Leu Ala Asp Pro His Gly Leu Gln Phe Gly Ar

#g Arg Arg Thr Glu Thr

610

#   615

#   620

Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cy

#s Asp Thr Asp Ala Leu

625                 6

#30                 6

#35                 6

#40

Val Glu Asp Leu Leu Arg Ser Gly Ser Thr Se

#r Pro His Thr Val Ser

645

#               650

#               655

Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Se

#r Cys Ser Arg Asp Cys

660

#           665

#           670

Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cy

#s Thr Asn Pro Glu Pro

675

#       680

#       685

Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Al

#a Ala Glu Tyr Gln Asp

690

#   695

#   700

Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Al

#a Trp Ser Cys Trp Thr

705                 7

#10                 7

#15                 7

#20

Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gl

#y Gly His Tyr Gln Arg

725

#               730

#               735

Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pr

#o Gly Glu Asp Ile Cys

740

#           745

#           750

Leu Gly Leu His Thr Glu Glu Ala Leu Cys Al

#a Thr Gln Ala Cys Pro

755

#       760

#       765

Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Ly

#s Cys Thr Asp Asp Gly

770

#   775

#   780

Ala Gln Ser Arg Ser Arg His Cys Glu Glu Le

#u Leu Pro Gly Ser Ser

785                 7

#90                 7

#95                 8

#00

Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pr

#o Cys Pro Tyr Ser Glu

805

#               810

#               815

Ile Pro Val Ile Leu Pro Ala Ser Ser Met Gl

#u Glu Ala Thr Gly Cys

820

#           825

#           830

Ala Gly Phe Asn Leu Ile His Leu Val Ala Th

#r Gly Ile Ser Cys Phe

835

#       840

#       845

Leu Gly Ser Gly Leu Leu Thr Leu Ala Val Ty

#r Leu Ser Cys Gln His

850

#   855

#   860

Cys Gln Arg Gln Ser Gln Glu Ser Thr Leu Va

#l His Pro Ala Thr Pro

865                 8

#70                 8

#75                 8

#80

Asn His Leu His Tyr Lys Gly Gly Gly Thr Pr

#o Lys Asn Glu Lys Tyr

885

#               890

#               895

Thr Pro Met Glu Phe Lys Thr Leu Asn Lys As

#n Asn Leu Ile Pro Asp

900

#           905

#           910

Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gln Th

#r Asn Val Tyr Thr Thr

915

#       920

#       925

Thr Tyr Tyr Pro Ser Pro Leu Asn Lys His Se

#r Phe Arg Pro Glu Ala

930

#   935

#   940

Ser Pro Gly Gln Arg Cys Phe Pro Asn Ser

945                 9

#50

<210> SEQ ID NO 15

<211> LENGTH: 2820

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 15

atgtgtggaa ccaatgcctt ttcccccatg tgcaccagca gacaggtggg ga

#acctcagc     60

cggactattg agaagatcaa tggtgtggcc cgctgcccct atgacccacg cc

#acaactcc    120

acagctgtca tctcctccca gggggagctc tatgcagcca cggtcatcga ct

#tctcaggt    180

cgggaccctg ccatctaccg cagcctgggc agtgggccac cgcttcgcac tg

#cccaatat    240

aactccaagt ggcttaatga gccaaacttc gtggcagcct atgatattgg gc

#tgtttgca    300

tacttcttcc tgcgggagaa cgcagtggag cacgactgtg gacgcaccgt gt

#actctcgc    360

gtggcccgcg tgtgcaagaa tgacgtgggg ggccgattcc tgctggagga ca

#catggacc    420

acattcatga aggcccggct caactgctcc cgcccgggcg aggtcccctt ct

#actataac    480

gagctgcaga gtgccttcca cttgccrgag caggacctca tctatggagt tt

#tcacaacc    540

aacgtaaaca gcatygcggc ttctgctgtc tgcgccttca acctcagtgc ta

#tctcccag    600

gctttcaatg gcccatttcg ctaccaggag aaccccaggg ctgcctggct cc

#ccatagcc    660

aaccccatcc ccaatttcca gtgtggcacc ctgcctgaga ccggtcccaa cg

#agaacctg    720

acggagcgca gcctgcagga cgcgcagcgc ctcttcctga tgagcgaggc cg

#tgcagccg    780

gtgacacccg agccctgtgt cacccaggac agcgtgcgct tctcacacct cg

#tggtggac    840

ctggtgcagg ctaaagacac gctctaccat gtactctaca ttggcaccga gt

#cgggcacc    900

atcctgaagg cgctgtccac ggcgagccgc agcctccacg gctgctacct gg

#aggagctg    960

cacgtgctgc cccccgggcg ccgcgagccc ctgcgcagcc tgcgcatcct gc

#acagcgcc   1020

cgcgcgctct tcgtggggct gagagacggc gtcctgcggg tcccactgga ga

#ggtgcgcc   1080

gcctaccgca gccagggggc atgcctgggg gcccgggacc cgtactgtgg ct

#gggacggg   1140

aagcagcaac gttgcagcac actcgaggac agctccaaca tgagcctctg ga

#cccagaac   1200

atcaccgcct gtcctgtgcg gaatgtgaca cgggatgggg gcttcggccc at

#ggtcacca   1260

tggcaaccat gtgagcactt ggatggggac aactcaggct cttgcctgtg tc

#gagctcga   1320

tcctgtgatt cccctcgacc ccgctgtggg ggccttgact gcctggggcc ag

#ccatccac   1380

atcgccaact gctccaggaa tggggcgtgg accccgtggt catcgtgggc gc

#tgtgcagc   1440

acgtcctgtg gcatcggctt ccaggtccgc cagcgaagtt gcagcaaccc tg

#ctccccgc   1500

cacgggggcc gcatctgcgt gggcaagagc cgggaggaac ggttctgtaa tg

#agaacacg   1560

ccttgcccgg tgcccatctt ctgggcttcc tggggctcct ggagcaagtg ca

#gcagcaac   1620

tgtggagggg gcatgcagtc gcggcgtcgg gcctgcgaga acggcaactc ct

#gcctgggc   1680

tgcggcgtgg agttcaagac gtgcaacccc gagggctgcc ccgaagtgcg gc

#gcaacacc   1740

ccctggacgc cgtggctgcc cgtgaacgtg acgcagggcg gggcacggca gg

#agcagcgg   1800

ttccgcttca cctgccgcgc gccccttgca gacccgcacg gcctgcagtt cg

#gcaggaga   1860

aggaccgaga cgaggacctg tcccgcggac ggctccggct cctgcgacac cg

#acgccctg   1920

gtggaggacc tcctgcgcag cgggagcacc tccccgcaca cggtgagcgg gg

#gctgggcc   1980

gcctggggcc cgtggtcgtc ctgctcccgg gactgcgagc tgggcttccg cg

#tccgcaag   2040

agaacgtgca ctaacccgga gccccgcaac gggggcctgc cctgcgtggg cg

#atgctgcc   2100

gagtaccagg actgcaaccc ccaggcttgc ccagttcggg gtgcttggtc ct

#gctggacc   2160

tcatggtctc catgctcagc ttcctgtggt gggggtcact atcaacgcac cc

#gttcctgc   2220

accagccccg caccctcccc aggtgaggac atctgtctcg ggctgcacac gg

#aggaggca   2280

ctatgtgcca cacaggcctg cccagaaggc tggtcgccct ggtctgagtg ga

#gtaagtgc   2340

actgacgacg gagcccagag ccgaagccgg cactgtgagg agctcctccc ag

#ggtccagc   2400

gcctgtgctg gaaacagcag ccagagccgc ccctgcccct acagcgagat tc

#ccgggttc   2460

aatctcatcc acttggtggc cacgggcatc tcctgcttct tgggctctgg gc

#tcctgacc   2520

ctagcagtgt acctgtcttg ccagcactgc cagcgtcagt cccaggagtc ca

#cactggtc   2580

catcctgcca cccccaacca tttgcactac aagggcggag gcaccccgaa ga

#atgaaaag   2640

tacacaccca tggaattcaa gaccctgaac aagaataact tgatccctga tg

#acagagcc   2700

aacttctacc cattgcagca gaccaatgtg tacacgacta cttactaccc aa

#gccccctg   2760

aacaaacaca gcttccggcc cgaggcctca cctggacaac ggtgcttccc ca

#acagctga   2820

<210> SEQ ID NO 16

<211> LENGTH: 939

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 16

Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cy

#s Thr Ser Arg Gln Val

1               5

#                10

#                15

Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile As

#n Gly Val Ala Arg Cys

20

#            25

#            30

Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Va

#l Ile Ser Ser Gln Gly

35

#        40

#        45

Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Se

#r Gly Arg Asp Pro Ala

50

#    55

#    60

Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Le

#u Arg Thr Ala Gln Tyr

65

#70

#75

#80

Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Va

#l Ala Ala Tyr Asp Ile

85

#                90

#                95

Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu As

#n Ala Val Glu His Asp

100

#           105

#           110

Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Ar

#g Val Cys Lys Asn Asp

115

#       120

#       125

Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Tr

#p Thr Thr Phe Met Lys

130

#   135

#   140

Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Va

#l Pro Phe Tyr Tyr Asn

145                 1

#50                 1

#55                 1

#60

Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gl

#n Asp Leu Ile Tyr Gly

165

#               170

#               175

Val Phe Thr Thr Asn Val Asn Ser Ile Ala Al

#a Ser Ala Val Cys Ala

180

#           185

#           190

Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe As

#n Gly Pro Phe Arg Tyr

195

#       200

#       205

Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Il

#e Ala Asn Pro Ile Pro

210

#   215

#   220

Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gl

#y Pro Asn Glu Asn Leu

225                 2

#30                 2

#35                 2

#40

Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Le

#u Phe Leu Met Ser Glu

245

#               250

#               255

Ala Val Gln Pro Val Thr Pro Glu Pro Cys Va

#l Thr Gln Asp Ser Val

260

#           265

#           270

Arg Phe Ser His Leu Val Val Asp Leu Val Gl

#n Ala Lys Asp Thr Leu

275

#       280

#       285

Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gl

#y Thr Ile Leu Lys Ala

290

#   295

#   300

Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cy

#s Tyr Leu Glu Glu Leu

305                 3

#10                 3

#15                 3

#20

His Val Leu Pro Pro Gly Arg Arg Glu Pro Le

#u Arg Ser Leu Arg Ile

325

#               330

#               335

Leu His Ser Ala Arg Ala Leu Phe Val Gly Le

#u Arg Asp Gly Val Leu

340

#           345

#           350

Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Ar

#g Ser Gln Gly Ala Cys

355

#       360

#       365

Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp As

#p Gly Lys Gln Gln Arg

370

#   375

#   380

Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Se

#r Leu Trp Thr Gln Asn

385                 3

#90                 3

#95                 4

#00

Ile Thr Ala Cys Pro Val Arg Asn Val Thr Ar

#g Asp Gly Gly Phe Gly

405

#               410

#               415

Pro Trp Ser Pro Trp Gln Pro Cys Glu His Le

#u Asp Gly Asp Asn Ser

420

#           425

#           430

Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys As

#p Ser Pro Arg Pro Arg

435

#       440

#       445

Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Il

#e His Ile Ala Asn Cys

450

#   455

#   460

Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Se

#r Trp Ala Leu Cys Ser

465                 4

#70                 4

#75                 4

#80

Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gl

#n Arg Ser Cys Ser Asn

485

#               490

#               495

Pro Ala Pro Arg His Gly Gly Arg Ile Cys Va

#l Gly Lys Ser Arg Glu

500

#           505

#           510

Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pr

#o Val Pro Ile Phe Trp

515

#       520

#       525

Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Se

#r Asn Cys Gly Gly Gly

530

#   535

#   540

Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gl

#y Asn Ser Cys Leu Gly

545                 5

#50                 5

#55                 5

#60

Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Gl

#u Gly Cys Pro Glu Val

565

#               570

#               575

Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pr

#o Val Asn Val Thr Gln

580

#           585

#           590

Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Ph

#e Thr Cys Arg Ala Pro

595

#       600

#       605

Leu Ala Asp Pro His Gly Leu Gln Phe Gly Ar

#g Arg Arg Thr Glu Thr

610

#   615

#   620

Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cy

#s Asp Thr Asp Ala Leu

625                 6

#30                 6

#35                 6

#40

Val Glu Asp Leu Leu Arg Ser Gly Ser Thr Se

#r Pro His Thr Val Ser

645

#               650

#               655

Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Se

#r Cys Ser Arg Asp Cys

660

#           665

#           670

Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cy

#s Thr Asn Pro Glu Pro

675

#       680

#       685

Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Al

#a Ala Glu Tyr Gln Asp

690

#   695

#   700

Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Al

#a Trp Ser Cys Trp Thr

705                 7

#10                 7

#15                 7

#20

Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gl

#y Gly His Tyr Gln Arg

725

#               730

#               735

Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pr

#o Gly Glu Asp Ile Cys

740

#           745

#           750

Leu Gly Leu His Thr Glu Glu Ala Leu Cys Al

#a Thr Gln Ala Cys Pro

755

#       760

#       765

Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Ly

#s Cys Thr Asp Asp Gly

770

#   775

#   780

Ala Gln Ser Arg Ser Arg His Cys Glu Glu Le

#u Leu Pro Gly Ser Ser

785                 7

#90                 7

#95                 8

#00

Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pr

#o Cys Pro Tyr Ser Glu

805

#               810

#               815

Ile Pro Gly Phe Asn Leu Ile His Leu Val Al

#a Thr Gly Ile Ser Cys

820

#           825

#           830

Phe Leu Gly Ser Gly Leu Leu Thr Leu Ala Va

#l Tyr Leu Ser Cys Gln

835

#       840

#       845

His Cys Gln Arg Gln Ser Gln Glu Ser Thr Le

#u Val His Pro Ala Thr

850

#   855

#   860

Pro Asn His Leu His Tyr Lys Gly Gly Gly Th

#r Pro Lys Asn Glu Lys

865                 8

#70                 8

#75                 8

#80

Tyr Thr Pro Met Glu Phe Lys Thr Leu Asn Ly

#s Asn Asn Leu Ile Pro

885

#               890

#               895

Asp Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gl

#n Thr Asn Val Tyr Thr

900

#           905

#           910

Thr Thr Tyr Tyr Pro Ser Pro Leu Asn Lys Hi

#s Ser Phe Arg Pro Glu

915

#       920

#       925

Ala Ser Pro Gly Gln Arg Cys Phe Pro Asn Se

#r

930

#   935

<210> SEQ ID NO 17

<211> LENGTH: 4074

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 17

cccgcggtct cctcctccct gctctctccg agcgccgggt cgggagctag tt

#ggagcgcg     60

ggggttggtg ccagagccca gctccgccga gccgggcggg tcggcagcgc at

#ccagcggc    120

tgctgggagc ccgagcgcag cgggcgcggg cccgggtggg gactgcaccg ga

#gcgctgag    180

agctggaggc cgttcctgcg cggccgcccc attcccagac cggccgccag cc

#catctggt    240

tagctcccgc cgctccgcgc cgcccgggag tcgggagccg cggggaaccg gg

#cacctgca    300

cccgcctctg ggaggtcttc tcccctgtct gcctcccgga gctaggactg ca

#gaggggcc    360

tatcatggtg cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tc

#acactgct    420

ggtgtcccac ctctccagct cccaggatgt ctccagtgag cccagcagtg ag

#cagcagct    480

gtgcgccctt agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gg

#gtctctaa    540

cttcacctac cctggagccc gggatttctc ccagctggct ttggacccct cc

#gggracca    600

gctcatcgtg ggagccagga actacctctt cagactcagc cttgccaatg tc

#tctcttct    660

tcaggccaca gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gc

#aaagggaa    720

gactgaggag gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc gg

#aaggtgtt    780

catgtgtgga accaatgcct tttcccccat gtgcaccagc agacaggtgg gg

#aacctcag    840

ccggactatt gagaagatca atggtgtggc ccgctgcccc tatgacccac gc

#cacaactc    900

cacagctgtc atctcctccc agggggagct ctatgcagcc acggtcatcg ac

#ttctcagg    960

tcgggaccct gccatctacc gcagcctggg cagtgggcca ccgcttcgca ct

#gcccaata   1020

taactccaag tggcttaatg agccaaactt cgtggcagcc tatgatattg gg

#ctgtttgc   1080

atacttcttc ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tg

#tactctcg   1140

cgtggcccgc gtgtgcaaga atgacgtggg gggccgattc ctgctggagg ac

#acatggac   1200

cacattcatg aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tc

#tactataa   1260

cgagctgcag agtgccttcc acttgccrga gcaggacctc atctatggag tt

#ttcacaac   1320

caacgtaaac agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ct

#atctccca   1380

ggctttcaat ggcccatttc gctaccagga gaaccccagg gctgcctggc tc

#cccatagc   1440

caaccccatc cccaatttcc agtgtggcac cctgcctgag accggtccca ac

#gagaacct   1500

gacggagcgc agcctgcagg acgcgcagcg cctcttcctg atgagcgagg cc

#gtgcagcc   1560

ggtgacaccc gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tc

#gtggtgga   1620

cctggtgcag gctaaagaca cgctctacca tgtactctac attggcaccg ag

#tcgggcac   1680

catcctgaag gcgctgtcca cggcgagccg cagcctccac ggctgctacc tg

#gaggagct   1740

gcacgtgctg ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tg

#cacagcgc   1800

ccgcgcgctc ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg ag

#aggtgcgc   1860

cgcctaccgc agccaggggg catgcctggg ggcccgggac ccgtactgtg gc

#tgggacgg   1920

gaagcagcaa cgttgcagca cactcgagga cagctccaac atgagcctct gg

#acccagaa   1980

catcaccgcc tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc ca

#tggtcacc   2040

atggcaacca tgtgagcact tggatgggga caactcaggc tcttgcctgt gt

#cgagctcg   2100

atcctgtgat tcccctcgac cccgctgtgg gggccttgac tgcctggggc ca

#gccatcca   2160

catcgccaac tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cg

#ctgtgcag   2220

cacgtcctgt ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ct

#gctccccg   2280

ccacgggggc cgcatctgcg tgggcaagag ccgggaggaa cggttctgta at

#gagaacac   2340

gccttgcccg gtgcccatct tctgggcttc ctggggctcc tggagcaagt gc

#agcagcaa   2400

ctgtggaggg ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cc

#tgcctggg   2460

ctgcggcgtg gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc gg

#cgcaacac   2520

cccctggacg ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc ag

#gagcagcg   2580

gttccgcttc acctgccgcg cgccccttgc agacccgcac ggcctgcagt tc

#ggcaggag   2640

aaggaccgag acgaggacct gtcccgcgga cggctccggc tcctgcgaca cc

#gacgccct   2700

ggtggaggac ctcctgcgca gcgggagcac ctccccgcac acggtgagcg gg

#ggctgggc   2760

cgcctggggc ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gc

#gtccgcaa   2820

gagaacgtgc actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gc

#gatgctgc   2880

cgagtaccag gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cc

#tgctggac   2940

ctcatggtct ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cc

#cgttcctg   3000

caccagcccc gcaccctccc caggtgagga catctgtctc gggctgcaca cg

#gaggaggc   3060

actatgtgcc acacaggcct gcccagaagg ctggtcgccc tggtctgagt gg

#agtaagtg   3120

cactgacgac ggagcccaga gccgaagccg gcactgtgag gagctcctcc ca

#gggtccag   3180

cgcctgtgct ggaaacagca gccagagccg cccctgcccc tacagcgaga tt

#cccgtcat   3240

cctgccagcc tccagcatgg aggaggccac cggctgtgca gggttcaatc tc

#atccactt   3300

ggtggccacg ggcatctcct gcttcttggg ctctgggctc ctgaccctag ca

#gtgtacct   3360

gtcttgccag cactgccagc gtcagtccca ggagtccaca ctggtccatc ct

#gccacccc   3420

caaccatttg cactacaagg gcggaggcac cccgaagaat gaaaagtaca ca

#cccatgga   3480

attcaagacc ctgaacaaga ataacttgat ccctgatgac agagccaact tc

#tacccatt   3540

gcagcagacc aatgtgtaca cgactactta ctacccaagc cccctgaaca aa

#cacagctt   3600

ccggcccgag gcctcacctg gacaacggtg cttccccaac agctgatacc gc

#cgtcctgg   3660

ggacttgggc ttcttgcctt cataaggcac agagcagatg gagatgggac ag

#tggagcca   3720

gtttggtttt ctccctctgc actaggccaa gaacttgctg ccttgcctgt gg

#ggggtccc   3780

atccggcttc agagagctct ggctggcatt gaccatgggg gaaagggctg gt

#ttcaggct   3840

gacatatggc cgcaggtcca gttcagccca ggtctctcat ggttatcttc ca

#acccactg   3900

tcacgctgac actatgctgc catgcctggg ctgtggacct actgggcatt tg

#aggaattg   3960

gagaatggag atggcaagag ggcaggcttt taagtttggg ttggagacaa ct

#tcctgtgg   4020

cccccacaag ctgagtctgg ccttctccag ctggccccaa aaaaggcctt tg

#ct         4074

<210> SEQ ID NO 18

<211> LENGTH: 648

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 18

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atggttag

#               648

<210> SEQ ID NO 19

<211> LENGTH: 215

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 19

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Gly

210

#   215

<210> SEQ ID NO 20

<211> LENGTH: 1491

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 20

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcaggta gcccttctct gtgaccctta a

#           1491

<210> SEQ ID NO 21

<211> LENGTH: 496

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 21

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln Val Al

#a Leu Leu Cys Asp Pro

485

#               490

#               495

<210> SEQ ID NO 22

<211> LENGTH: 2109

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 22

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacaggt cccagggaag caggacagca ctgatacagg acatagagag ag

#gaaatcga   1680

ggctgtgaga gcagcaggga tacaggcagg gctctgcagg tccatatggg ct

#caatgtca   1740

ccaccctctg catggccctg tgtgctggat ggtcctgaaa ccagacaagt cc

#tctgccag   1800

ccacctaagc cctgcgtaca ttcacatgca cacatggaag aatgtttatc gg

#ctgggctg   1860

cagtgccccc accctcacct tctcctggtg cattcttgtt tcatccctgc tt

#ctggactt   1920

ggggtaccct cccaattgcc acatcctatc tggtcctctt ccccagcccc at

#gtggtgac   1980

ctctttgtca agagcttggg aacgggccag cctggggagg taagactgca tc

#actcccct   2040

cctctccctt cctgtgtggc ccttgtgaat cagcctcccc actctccttg gt

#cattctca   2100

agagtatga

#

#

#       2109

<210> SEQ ID NO 23

<211> LENGTH: 702

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 23

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln His Se

#r Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Ser

530

#   535

#   540

Gln Gly Ser Arg Thr Ala Leu Ile Gln Asp Il

#e Glu Arg Gly Asn Arg

545                 5

#50                 5

#55                 5

#60

Gly Cys Glu Ser Ser Arg Asp Thr Gly Arg Al

#a Leu Gln Val His Met

565

#               570

#               575

Gly Ser Met Ser Pro Pro Ser Ala Trp Pro Cy

#s Val Leu Asp Gly Pro

580

#           585

#           590

Glu Thr Arg Gln Val Leu Cys Gln Pro Pro Ly

#s Pro Cys Val His Ser

595

#       600

#       605

His Ala His Met Glu Glu Cys Leu Ser Ala Gl

#y Leu Gln Cys Pro His

610

#   615

#   620

Pro His Leu Leu Leu Val His Ser Cys Phe Il

#e Pro Ala Ser Gly Leu

625                 6

#30                 6

#35                 6

#40

Gly Val Pro Ser Gln Leu Pro His Pro Ile Tr

#p Ser Ser Ser Pro Ala

645

#               650

#               655

Pro Cys Gly Asp Leu Phe Val Lys Ser Leu Gl

#y Thr Gly Gln Pro Gly

660

#           665

#           670

Glu Val Arg Leu His His Ser Pro Pro Leu Pr

#o Ser Cys Val Ala Leu

675

#       680

#       685

Val Asn Gln Pro Pro His Ser Pro Trp Ser Ph

#e Ser Arg Val

690

#   695

#   700

<210> SEQ ID NO 24

<211> LENGTH: 2094

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 24

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacagga cagcactgat acaggacata gagagaggaa atcgaggctg tg

#agagcagc   1680

agggatacag gcagggctct gcaggtccat atgggctcaa tgtcaccacc ct

#ctgcatgg   1740

ccctgtgtgc tggatggtcc tgaaaccaga caagtcctct gccagccacc ta

#agccctgc   1800

gtacattcac atgcacacat ggaagaatgt ttatcggctg ggctgcagtg cc

#cccaccct   1860

caccttctcc tggtgcattc ttgtttcatc cctgcttctg gacttggggt ac

#cctcccaa   1920

ttgccacatc ctatctggtc ctcttcccca gccccatgtg gtgacctctt tg

#tcaagagc   1980

ttgggaacgg gccagcctgg ggaggtaaga ctgcatcact cccctcctct cc

#cttcctgt   2040

gtggcccttg tgaatcagcc tccccactct ccttggtcat tctcaagagt at

#ga         2094

<210> SEQ ID NO 25

<211> LENGTH: 697

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 25

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln His Se

#r Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Thr

530

#   535

#   540

Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Ar

#g Gly Cys Glu Ser Ser

545                 5

#50                 5

#55                 5

#60

Arg Asp Thr Gly Arg Ala Leu Gln Val His Me

#t Gly Ser Met Ser Pro

565

#               570

#               575

Pro Ser Ala Trp Pro Cys Val Leu Asp Gly Pr

#o Glu Thr Arg Gln Val

580

#           585

#           590

Leu Cys Gln Pro Pro Lys Pro Cys Val His Se

#r His Ala His Met Glu

595

#       600

#       605

Glu Cys Leu Ser Ala Gly Leu Gln Cys Pro Hi

#s Pro His Leu Leu Leu

610

#   615

#   620

Val His Ser Cys Phe Ile Pro Ala Ser Gly Le

#u Gly Val Pro Ser Gln

625                 6

#30                 6

#35                 6

#40

Leu Pro His Pro Ile Trp Ser Ser Ser Pro Al

#a Pro Cys Gly Asp Leu

645

#               650

#               655

Phe Val Lys Ser Leu Gly Thr Gly Gln Pro Gl

#y Glu Val Arg Leu His

660

#           665

#           670

His Ser Pro Pro Leu Pro Ser Cys Val Ala Le

#u Val Asn Gln Pro Pro

675

#       680

#       685

His Ser Pro Trp Ser Phe Ser Arg Val

690

#   695

<210> SEQ ID NO 26

<211> LENGTH: 2532

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 26

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacaggt cccagggaag caggacagca ctgatacagg acatagagag ag

#gaaatcga   1680

ggctgtgaga gcagcaggga tacagggcca ccaccaccac tgaagacccg ct

#ctgtgctc   1740

cggggtgatg atgtcctcct gccctgtgac cagccatcca acctggcccg gg

#ccttgtgg   1800

ctactcaatg ggagcatggg cctgagcgat gggcagggtg gctaccgtgt gg

#gcgtggac   1860

gggctgctgg ttacagatgc acagcctgag cacagtggca actatggctg ct

#atgccgag   1920

gaaaatggcc tccgcaccct gctggcctcc tatagtctca cagtccggcc ag

#ccactcct   1980

gccccagctc caaaagcccc tgccacacct ggggcacagc tggcacctga tg

#tgagactg   2040

ctctatgtgc tagccattgc cgcgcttggt ggccyctgcc tcatcctggc ct

#cctccctc   2100

ctctatgtgg cctgtctgcg ggaaggcaga cgagggcgcc gacggaaata ct

#cactgggt   2160

cgggccagcc gggcaggagg atctgcggtg caactgcaga cagtctcagg cc

#agtgtcct   2220

ggagaggaag atgagggtga tgatgagggg gctgggggcc tggagggcag ct

#gtctccag   2280

atcatccctg gggagggagc cccagcccca ccacccccac cgcccccacc gc

#caccggct   2340

gagctgacca atggcttggt ggcactgccc agccggctgc ggaggatgaa tg

#gcaatagc   2400

tatgtgcttc tgaggcagag caacaatgga gtaccagcag ggccctgctc ct

#tcgccgag   2460

gaactcagcc gcatcctgga aaaaaggaag cacacgcagc tcgtggagca gc

#tagatgag   2520

agctctgtct ga

#

#

#     2532

<210> SEQ ID NO 27

<211> LENGTH: 843

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 27

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln His Se

#r Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Ser

530

#   535

#   540

Gln Gly Ser Arg Thr Ala Leu Ile Gln Asp Il

#e Glu Arg Gly Asn Arg

545                 5

#50                 5

#55                 5

#60

Gly Cys Glu Ser Ser Arg Asp Thr Gly Pro Pr

#o Pro Pro Leu Lys Thr

565

#               570

#               575

Arg Ser Val Leu Arg Gly Asp Asp Val Leu Le

#u Pro Cys Asp Gln Pro

580

#           585

#           590

Ser Asn Leu Ala Arg Ala Leu Trp Leu Leu As

#n Gly Ser Met Gly Leu

595

#       600

#       605

Ser Asp Gly Gln Gly Gly Tyr Arg Val Gly Va

#l Asp Gly Leu Leu Val

610

#   615

#   620

Thr Asp Ala Gln Pro Glu His Ser Gly Asn Ty

#r Gly Cys Tyr Ala Glu

625                 6

#30                 6

#35                 6

#40

Glu Asn Gly Leu Arg Thr Leu Leu Ala Ser Ty

#r Ser Leu Thr Val Arg

645

#               650

#               655

Pro Ala Thr Pro Ala Pro Ala Pro Lys Ala Pr

#o Ala Thr Pro Gly Ala

660

#           665

#           670

Gln Leu Ala Pro Asp Val Arg Leu Leu Tyr Va

#l Leu Ala Ile Ala Ala

675

#       680

#       685

Leu Gly Gly Leu Cys Leu Ile Leu Ala Ser Se

#r Leu Leu Tyr Val Ala

690

#   695

#   700

Cys Leu Arg Glu Gly Arg Arg Gly Arg Arg Ar

#g Lys Tyr Ser Leu Gly

705                 7

#10                 7

#15                 7

#20

Arg Ala Ser Arg Ala Gly Gly Ser Ala Val Gl

#n Leu Gln Thr Val Ser

725

#               730

#               735

Gly Gln Cys Pro Gly Glu Glu Asp Glu Gly As

#p Asp Glu Gly Ala Gly

740

#           745

#           750

Gly Leu Glu Gly Ser Cys Leu Gln Ile Ile Pr

#o Gly Glu Gly Ala Pro

755

#       760

#       765

Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pr

#o Ala Glu Leu Thr Asn

770

#   775

#   780

Gly Leu Val Ala Leu Pro Ser Arg Leu Arg Ar

#g Met Asn Gly Asn Ser

785                 7

#90                 7

#95                 8

#00

Tyr Val Leu Leu Arg Gln Ser Asn Asn Gly Va

#l Pro Ala Gly Pro Cys

805

#               810

#               815

Ser Phe Ala Glu Glu Leu Ser Arg Ile Leu Gl

#u Lys Arg Lys His Thr

820

#           825

#           830

Gln Leu Val Glu Gln Leu Asp Glu Ser Ser Va

#l

835

#       840

<210> SEQ ID NO 28

<211> LENGTH: 2517

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 28

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacagga cagcactgat acaggacata gagagaggaa atcgaggctg tg

#agagcagc   1680

agggatacag ggccaccacc accactgaag acccgctctg tgctccgggg tg

#atgatgtc   1740

ctcctgccct gtgaccagcc atccaacctg gcccgggcct tgtggctact ca

#atgggagc   1800

atgggcctga gcgatgggca gggtggctac cgtgtgggcg tggacgggct gc

#tggttaca   1860

gatgcacagc ctgagcacag tggcaactat ggctgctatg ccgaggaaaa tg

#gcctccgc   1920

accctgctgg cctcctatag tctcacagtc cggccagcca ctcctgcccc ag

#ctccaaaa   1980

gcccctgcca cacctggggc acagctggca cctgatgtga gactgctcta tg

#tgctagcc   2040

attgccgcgc ttggtggccy ctgcctcatc ctggcctcct ccctcctcta tg

#tggcctgt   2100

ctgcgggaag gcagacgagg gcgccgacgg aaatactcac tgggtcgggc ca

#gccgggca   2160

ggaggatctg cggtgcaact gcagacagtc tcaggccagt gtcctggaga gg

#aagatgag   2220

ggtgatgatg agggggctgg gggcctggag ggcagctgtc tccagatcat cc

#ctggggag   2280

ggagccccag ccccaccacc cccaccgccc ccaccgccac cggctgagct ga

#ccaatggc   2340

ttggtggcac tgcccagccg gctgcggagg atgaatggca atagctatgt gc

#ttctgagg   2400

cagagcaaca atggagtacc agcagggccc tgctccttcg ccgaggaact ca

#gccgcatc   2460

ctggaaaaaa ggaagcacac gcagctcgtg gagcagctag atgagagctc tg

#tctga      2517

<210> SEQ ID NO 29

<211> LENGTH: 838

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 29

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe

#Arg Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

G

lu Asn Leu Val Ile Ser Leu Leu Gln His Ser

# Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Thr

530

#   535

#   540

Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Ar

#g Gly Cys Glu Ser Ser

545                 5

#50                 5

#55                 5

#60

Arg Asp Thr Gly Pro Pro Pro Pro Leu Lys Th

#r Arg Ser Val Leu Arg

565

#               570

#               575

Gly Asp Asp Val Leu Leu Pro Cys Asp Gln Pr

#o Ser Asn Leu Ala Arg

580

#           585

#           590

Ala Leu Trp Leu Leu Asn Gly Ser Met Gly Le

#u Ser Asp Gly Gln Gly

595

#       600

#       605

Gly Tyr Arg Val Gly Val Asp Gly Leu Leu Va

#l Thr Asp Ala Gln Pro

610

#   615

#   620

Glu His Ser Gly Asn Tyr Gly Cys Tyr Ala Gl

#u Glu Asn Gly Leu Arg

625                 6

#30                 6

#35                 6

#40

Thr Leu Leu Ala Ser Tyr Ser Leu Thr Val Ar

#g Pro Ala Thr Pro Ala

645

#               650

#               655

Pro Ala Pro Lys Ala Pro Ala Thr Pro Gly Al

#a Gln Leu Ala Pro Asp

660

#           665

#           670

Val Arg Leu Leu Tyr Val Leu Ala Ile Ala Al

#a Leu Gly Gly Leu Cys

675

#       680

#       685

Leu Ile Leu Ala Ser Ser Leu Leu Tyr Val Al

#a Cys Leu Arg Glu Gly

690

#   695

#   700

Arg Arg Gly Arg Arg Arg Lys Tyr Ser Leu Gl

#y Arg Ala Ser Arg Ala

705                 7

#10                 7

#15                 7

#20

Gly Gly Ser Ala Val Gln Leu Gln Thr Val Se

#r Gly Gln Cys Pro Gly

725

#               730

#               735

Glu Glu Asp Glu Gly Asp Asp Glu Gly Ala Gl

#y Gly Leu Glu Gly Ser

740

#           745

#           750

Cys Leu Gln Ile Ile Pro Gly Glu Gly Ala Pr

#o Ala Pro Pro Pro Pro

755

#       760

#       765

Pro Pro Pro Pro Pro Pro Ala Glu Leu Thr As

#n Gly Leu Val Ala Leu

770

#   775

#   780

Pro Ser Arg Leu Arg Arg Met Asn Gly Asn Se

#r Tyr Val Leu Leu Arg

785                 7

#90                 7

#95                 8

#00

Gln Ser Asn Asn Gly Val Pro Ala Gly Pro Cy

#s Ser Phe Ala Glu Glu

805

#               810

#               815

Leu Ser Arg Ile Leu Glu Lys Arg Lys His Th

#r Gln Leu Val Glu Gln

820

#           825

#           830

Leu Asp Glu Ser Ser Val

835

<210> SEQ ID NO 30

<211> LENGTH: 2613

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 30

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacaggt cccagggaag caggacagca ctgatacagg acatagagag ag

#gaaatcga   1680

ggctgtgaga gcagcaggga tacagggcca ccaccaccac tgaagacccg ct

#ctgtgctc   1740

cggggtgatg atgtcctcct gccctgtgac cagccatcca acctggcccg gg

#ccttgtgg   1800

ctactcaatg ggagcatggg cctgagcgat gggcagggtg gctaccgtgt gg

#gcgtggac   1860

gggctgctgg ttacagatgc acagcctgag cacagtggca actatggctg ct

#atgccgag   1920

gaaaatggcc tccgcaccct gctggcctcc tatagtctca cagtccggcc ag

#ccactcct   1980

gccccagctc caaaagcccc tgccacacct ggggcacagc tggcacctga tg

#tgagactg   2040

ctctatgtgc tagccattgc cgcgcttggt ggccyctgcc tcatcctggc ct

#cctccctc   2100

ctctatgtgg cctgtctgcg ggaaggcaga cgagggcgcc gacggaaata ct

#cactgggt   2160

cgggccagcc gggcaggagg atctgcggtg caactgcaga cagtctcagg ca

#gggctctg   2220

caggtccata tgggctcaat gtcaccaccc tctgcatggc cctgtgtgct gg

#atggtcct   2280

gaaaccagac aagtcctctg ccagccacct aagccctgcg tacattcaca tg

#cacacatg   2340

gaagaatgtt tatcggctgg gctgcagtgc ccccaccctc accttctcct gg

#tgcattct   2400

tgtttcatcc ctgcttctgg acttggggta ccctcccaat tgccacatcc ta

#tctggtcc   2460

tcttccccag ccccatgtgg tgacctcttt gtcaagagct tgggaacggg cc

#agcctggg   2520

gaggtaagac tgcatcactc ccctcctctc ccttcctgtg tggcccttgt ga

#atcagcct   2580

ccccactctc cttggtcatt ctcaagagta tga

#

#       2613

<210> SEQ ID NO 31

<211> LENGTH: 870

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 31

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln His Se

#r Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Ser

530

#   535

#   540

Gln Gly Ser Arg Thr Ala Leu Ile Gln Asp Il

#e Glu Arg Gly Asn Arg

545                 5

#50                 5

#55                 5

#60

Gly Cys Glu Ser Ser Arg Asp Thr Gly Pro Pr

#o Pro Pro Leu Lys Thr

565

#               570

#               575

Arg Ser Val Leu Arg Gly Asp Asp Val Leu Le

#u Pro Cys Asp Gln Pro

580

#           585

#           590

Ser Asn Leu Ala Arg Ala Leu Trp Leu Leu As

#n Gly Ser Met Gly Leu

595

#       600

#       605

Ser Asp Gly Gln Gly Gly Tyr Arg Val Gly Va

#l Asp Gly Leu Leu Val

610

#   615

#   620

Thr Asp Ala Gln Pro Glu His Ser Gly Asn Ty

#r Gly Cys Tyr Ala Glu

625                 6

#30                 6

#35                 6

#40

Glu Asn Gly Leu Arg Thr Leu Leu Ala Ser Ty

#r Ser Leu Thr Val Arg

645

#               650

#               655

Pro Ala Thr Pro Ala Pro Ala Pro Lys Ala Pr

#o Ala Thr Pro Gly Ala

660

#           665

#           670

Gln Leu Ala Pro Asp Val Arg Leu Leu Tyr Va

#l Leu Ala Ile Ala Ala

675

#       680

#       685

Leu Gly Gly Leu Cys Leu Ile Leu Ala Ser Se

#r Leu Leu Tyr Val Ala

690

#   695

#   700

Cys Leu Arg Glu Gly Arg Arg Gly Arg Arg Ar

#g Lys Tyr Ser Leu Gly

705                 7

#10                 7

#15                 7

#20

Arg Ala Ser Arg Ala Gly Gly Ser Ala Val Gl

#n Leu Gln Thr Val Ser

725

#               730

#               735

Gly Arg Ala Leu Gln Val His Met Gly Ser Me

#t Ser Pro Pro Ser Ala

740

#           745

#           750

Trp Pro Cys Val Leu Asp Gly Pro Glu Thr Ar

#g Gln Val Leu Cys Gln

755

#       760

#       765

Pro Pro Lys Pro Cys Val His Ser His Ala Hi

#s Met Glu Glu Cys Leu

770

#   775

#   780

Ser Ala Gly Leu Gln Cys Pro His Pro His Le

#u Leu Leu Val His Ser

785                 7

#90                 7

#95                 8

#00

Cys Phe Ile Pro Ala Ser Gly Leu Gly Val Pr

#o Ser Gln Leu Pro His

805

#               810

#               815

Pro Ile Trp Ser Ser Ser Pro Ala Pro Cys Gl

#y Asp Leu Phe Val Lys

820

#           825

#           830

Ser Leu Gly Thr Gly Gln Pro Gly Glu Val Ar

#g Leu His His Ser Pro

835

#       840

#       845

Pro Leu Pro Ser Cys Val Ala Leu Val Asn Gl

#n Pro Pro His Ser Pro

850

#   855

#   860

Trp Ser Phe Ser Arg Val

865                 8

#70

<210> SEQ ID NO 32

<211> LENGTH: 2598

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 32

atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag

#tcccagga     60

ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca

#taccctat    120

gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa

#cactgctg    180

ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct

#ctctcagt    240

gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc

#cagagatg    300

caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc

#atgtgcgg    360

ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct

#tccagccc    420

ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg

#aggggaag    480

gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg

#gaggcctc    540

tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc

#gccaccca    600

cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt

#ttgtgttc    660

tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg

#tgtactac    720

ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc

#gcagcagt    780

caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga

#agatcctg    840

cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac

#tgtatgag    900

acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct

#tctatgca    960

gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc

#gctatgac   1020

ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg

#gttcccgg   1080

cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta

#tcacagat   1140

tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc

#tggacttt   1200

gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc

#ccctgctg   1260

ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc

#ctgctgga   1320

cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg

#ccgtagtc   1380

ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc

#agtctgtg   1440

gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta

#gcggagtc   1500

atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca

#tcttggcc   1560

cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca

#ccaccata   1620

gccaacagga cagcactgat acaggacata gagagaggaa atcgaggctg tg

#agagcagc   1680

agggatacag ggccaccacc accactgaag acccgctctg tgctccgggg tg

#atgatgtc   1740

ctcctgccct gtgaccagcc atccaacctg gcccgggcct tgtggctact ca

#atgggagc   1800

atgggcctga gcgatgggca gggtggctac cgtgtgggcg tggacgggct gc

#tggttaca   1860

gatgcacagc ctgagcacag tggcaactat ggctgctatg ccgaggaaaa tg

#gcctccgc   1920

accctgctgg cctcctatag tctcacagtc cggccagcca ctcctgcccc ag

#ctccaaaa   1980

gcccctgcca cacctggggc acagctggca cctgatgtga gactgctcta tg

#tgctagcc   2040

attgccgcgc ttggtggccy ctgcctcatc ctggcctcct ccctcctcta tg

#tggcctgt   2100

ctgcgggaag gcagacgagg gcgccgacgg aaatactcac tgggtcgggc ca

#gccgggca   2160

ggaggatctg cggtgcaact gcagacagtc tcaggcaggg ctctgcaggt cc

#atatgggc   2220

tcaatgtcac caccctctgc atggccctgt gtgctggatg gtcctgaaac ca

#gacaagtc   2280

ctctgccagc cacctaagcc ctgcgtacat tcacatgcac acatggaaga at

#gtttatcg   2340

gctgggctgc agtgccccca ccctcacctt ctcctggtgc attcttgttt ca

#tccctgct   2400

tctggacttg gggtaccctc ccaattgcca catcctatct ggtcctcttc cc

#cagcccca   2460

tgtggtgacc tctttgtcaa gagcttggga acgggccagc ctggggaggt aa

#gactgcat   2520

cactcccctc ctctcccttc ctgtgtggcc cttgtgaatc agcctcccca ct

#ctccttgg   2580

tcattctcaa gagtatga

#

#

#2598

<210> SEQ ID NO 33

<211> LENGTH: 865

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 33

Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se

#r Ile Leu Thr Ala Thr

1               5

#                10

#                15

Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se

#r Arg Glu Leu Asp Ala

20

#            25

#            30

Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le

#u Ser Gly Thr Arg His

35

#        40

#        45

Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le

#u Leu Leu Glu Glu Ala

50

#    55

#    60

Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al

#a Leu Phe Ser Leu Ser

65

#70

#75

#80

Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl

#u Ile His Trp Glu Ala

85

#                90

#                95

Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly

#s Gly Lys Asn Asn Gln

100

#           105

#           110

Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl

#n Arg Leu Asn Ser Thr

115

#       120

#       125

His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl

#n Pro Leu Cys Ala Ala

130

#   135

#   140

Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se

#r Phe Glu Glu Gly Lys

145                 1

#50                 1

#55                 1

#60

Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph

#e Thr Gly Leu Ile Ile

165

#               170

#               175

Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl

#u Phe Arg Ser Ile Pro

180

#           185

#           190

Asp Ile Arg Arg Ser Arg His Pro His Ser Le

#u Arg Thr Glu Glu Thr

195

#       200

#       205

Pro Met His Trp Leu Asn Asp Ala Glu Phe Va

#l Phe Ser Val Leu Val

210

#   215

#   220

Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As

#p Asp Lys Val Tyr Tyr

225                 2

#30                 2

#35                 2

#40

Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se

#r Gly Ser Phe Thr Gln

245

#               250

#               255

Ser Arg Ser Ser His Arg Val Ala Arg Val Al

#a Arg Val Cys Lys Gly

260

#           265

#           270

Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly

#s Trp Thr Ser Phe Leu

275

#       280

#       285

Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty

#r Glu Thr Leu Arg Gly

290

#   295

#   300

Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar

#g Thr His Phe Tyr Ala

305                 3

#10                 3

#15                 3

#20

Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le

#u Glu Ala Ser Ala Ile

325

#               330

#               335

Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va

#l Phe Ala Gly Pro Tyr

340

#           345

#           350

Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl

#y Arg Tyr Glu Gly Gly

355

#       360

#       365

Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th

#r Asp Ser Leu Arg Ser

370

#   375

#   380

Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se

#r Leu Val Leu Asp Phe

385                 3

#90                 3

#95                 4

#00

Val Lys Leu His Pro Leu Met Ala Arg Pro Va

#l Val Pro Thr Arg Gly

405

#               410

#               415

Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty

#r Thr His Leu Thr Gly

420

#           425

#           430

Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty

#r Asp Leu Leu Phe Leu

435

#       440

#       445

Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va

#l Val Leu Gly Ser Gly

450

#   455

#   460

Met His Ile Ile Glu Glu Thr Gln Val Phe Ar

#g Glu Ser Gln Ser Val

465                 4

#70                 4

#75                 4

#80

Glu Asn Leu Val Ile Ser Leu Leu Gln His Se

#r Leu Tyr Val Gly Ala

485

#               490

#               495

Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se

#r Cys Ser Arg Tyr Arg

500

#           505

#           510

Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr

#o Tyr Cys Gly Trp Asp

515

#       520

#       525

Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th

#r Ile Ala Asn Arg Thr

530

#   535

#   540

Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Ar

#g Gly Cys Glu Ser Ser

545                 5

#50                 5

#55                 5

#60

Arg Asp Thr Gly Pro Pro Pro Pro Leu Lys Th

#r Arg Ser Val Leu Arg

565

#               570

#               575

Gly Asp Asp Val Leu Leu Pro Cys Asp Gln Pr

#o Ser Asn Leu Ala Arg

580

#           585

#           590

Ala Leu Trp Leu Leu Asn Gly Ser Met Gly Le

#u Ser Asp Gly Gln Gly

595

#       600

#       605

Gly Tyr Arg Val Gly Val Asp Gly Leu Leu Va

#l Thr Asp Ala Gln Pro

610

#   615

#   620

Glu His Ser Gly Asn Tyr Gly Cys Tyr Ala Gl

#u Glu Asn Gly Leu Arg

625                 6

#30                 6

#35                 6

#40

Thr Leu Leu Ala Ser Tyr Ser Leu Thr Val Ar

#g Pro Ala Thr Pro Ala

645

#               650

#               655

Pro Ala Pro Lys Ala Pro Ala Thr Pro Gly Al

#a Gln Leu Ala Pro Asp

660

#           665

#           670

Val Arg Leu Leu Tyr Val Leu Ala Ile Ala Al

#a Leu Gly Gly Leu Cys

675

#       680

#       685

Leu Ile Leu Ala Ser Ser Leu Leu Tyr Val Al

#a Cys Leu Arg Glu Gly

690

#   695

#   700

Arg Arg Gly Arg Arg Arg Lys Tyr Ser Leu Gl

#y Arg Ala Ser Arg Ala

705                 7

#10                 7

#15                 7

#20

Gly Gly Ser Ala Val Gln Leu Gln Thr Val Se

#r Gly Arg Ala Leu Gln

725

#               730

#               735

Val His Met Gly Ser Met Ser Pro Pro Ser Al

#a Trp Pro Cys Val Leu

740

#           745

#           750

Asp Gly Pro Glu Thr Arg Gln Val Leu Cys Gl

#n Pro Pro Lys Pro Cys

755

#       760

#       765

Val His Ser His Ala His Met Glu Glu Cys Le

#u Ser Ala Gly Leu Gln

770

#   775

#   780

Cys Pro His Pro His Leu Leu Leu Val His Se

#r Cys Phe Ile Pro Ala

785                 7

#90                 7

#95                 8

#00

Ser Gly Leu Gly Val Pro Ser Gln Leu Pro Hi

#s Pro Ile Trp Ser Ser

805

#               810

#               815

Ser Pro Ala Pro Cys Gly Asp Leu Phe Val Ly

#s Ser Leu Gly Thr Gly

820

#           825

#           830

Gln Pro Gly Glu Val Arg Leu His His Ser Pr

#o Pro Leu Pro Ser Cys

835

#       840

#       845

Val Ala Leu Val Asn Gln Pro Pro His Ser Pr

#o Trp Ser Phe Ser Arg

850

#   855

#   860

Val

865

<210> SEQ ID NO 34

<211> LENGTH: 351

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 34

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatggtta g

#            351

<210> SEQ ID NO 35

<211> LENGTH: 116

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 35

Met Gln Ser Lys Cys His Gln Lys Gly Lys As

#n Asn Gln Thr Glu Cys

1               5

#                10

#                15

Phe Asn His Val Arg Phe Leu Gln Arg Leu As

#n Ser Thr His Leu Tyr

20

#            25

#            30

Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cy

#s Ala Ala Ile Asp Ala

35

#        40

#        45

Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Gl

#u Gly Lys Glu Lys Cys

50

#    55

#    60

Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Le

#u Ile Ile Asp Gly Gly

65

#70

#75

#80

Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Se

#r Ile Pro Asp Ile Arg

85

#                90

#                95

Arg Ser Arg His Pro His Ser Leu Arg Thr Gl

#u Glu Thr Pro Met His

100

#           105

#           110

Trp Leu Asn Gly

115

<210> SEQ ID NO 36

<211> LENGTH: 1194

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 36

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatgatgc gg

#agtttgtg    360

ttctccgtcc tcgtgcggga gagcaaggcc agtgcagtgg gtgatgatga ca

#aggtgtac    420

tacttcttca cggagcgtgc cactgaggag ggctctggca gcttcactca ga

#gccgcagc    480

agtcaccgtg tggcccgtgt ggctcgygtc tgcaagggag acctgggagg ga

#agaagatc    540

ctgcagaaga agtggacttc cttcctgaaa gcccgtctca tctgccacat tc

#cactgtat    600

gagacactgc gtggggtctg cagcctggat gctgaaacct caagccgtac ac

#acttctat    660

gcagccttca cgctgagcac acagtggaag accctggagg cctcagccat ct

#gccgctat    720

gacctggcag agatccaggc tgtctttgca ggaccctata tggaatacca gg

#atggttcc    780

cggcgctggg gtcgctatga gggtggggtg cctgagcccc ggcctggctc gt

#gtatcaca    840

gattcattgc gcagccaagg ctacaattca tcccaagact tgccatccct gg

#tcctggac    900

tttgtaaagt tgcacccact gatggctcgg cccgttgtgc ccacacgtgg ac

#ggcccctg    960

ctgctcaagc gcaacatacg ctacacacac cttacaggga cacctgtcac ca

#cgcctgct   1020

ggacctacct atgacctgct ctttctgggc acagctgatg gctggatcca ca

#aggccgta   1080

gtcctgggct ctgggatgca cattattgaa gagacacaag tgttcaggga gt

#cccagtct   1140

gtggaaaatc tagtcatctc tctattgcag gtagcccttc tctgtgaccc tt

#aa         1194

<210> SEQ ID NO 37

<211> LENGTH: 397

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 37

Met Gln Ser Lys Cys His Gln Lys Gly Lys As

#n Asn Gln Thr Glu Cys

1               5

#                10

#                15

Phe Asn His Val Arg Phe Leu Gln Arg Leu As

#n Ser Thr His Leu Tyr

20

#            25

#            30

Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cy

#s Ala Ala Ile Asp Ala

35

#        40

#        45

Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Gl

#u Gly Lys Glu Lys Cys

50

#    55

#    60

Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Le

#u Ile Ile Asp Gly Gly

65

#70

#75

#80

Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Se

#r Ile Pro Asp Ile Arg

85

#                90

#                95

Arg Ser Arg His Pro His Ser Leu Arg Thr Gl

#u Glu Thr Pro Met His

100

#           105

#           110

Trp Leu Asn Asp Ala Glu Phe Val Phe Ser Va

#l Leu Val Arg Glu Ser

115

#       120

#       125

Lys Ala Ser Ala Val Gly Asp Asp Asp Lys Va

#l Tyr Tyr Phe Phe Thr

130

#   135

#   140

Glu Arg Ala Thr Glu Glu Gly Ser Gly Ser Ph

#e Thr Gln Ser Arg Ser

145                 1

#50                 1

#55                 1

#60

Ser His Arg Val Ala Arg Val Ala Arg Val Cy

#s Lys Gly Asp Leu Gly

165

#               170

#               175

Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr Se

#r Phe Leu Lys Ala Arg

180

#           185

#           190

Leu Ile Cys His Ile Pro Leu Tyr Glu Thr Le

#u Arg Gly Val Cys Ser

195

#       200

#       205

Leu Asp Ala Glu Thr Ser Ser Arg Thr His Ph

#e Tyr Ala Ala Phe Thr

210

#   215

#   220

Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala Se

#r Ala Ile Cys Arg Tyr

225                 2

#30                 2

#35                 2

#40

Asp Leu Ala Glu Ile Gln Ala Val Phe Ala Gl

#y Pro Tyr Met Glu Tyr

245

#               250

#               255

Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr Gl

#u Gly Gly Val Pro Glu

260

#           265

#           270

Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser Le

#u Arg Ser Gln Gly Tyr

275

#       280

#       285

Asn Ser Ser Gln Asp Leu Pro Ser Leu Val Le

#u Asp Phe Val Lys Leu

290

#   295

#   300

His Pro Leu Met Ala Arg Pro Val Val Pro Th

#r Arg Gly Arg Pro Leu

305                 3

#10                 3

#15                 3

#20

Leu Leu Lys Arg Asn Ile Arg Tyr Thr His Le

#u Thr Gly Thr Pro Val

325

#               330

#               335

Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu Le

#u Phe Leu Gly Thr Ala

340

#           345

#           350

Asp Gly Trp Ile His Lys Ala Val Val Leu Gl

#y Ser Gly Met His Ile

355

#       360

#       365

Ile Glu Glu Thr Gln Val Phe Arg Glu Ser Gl

#n Ser Val Glu Asn Leu

370

#   375

#   380

Val Ile Ser Leu Leu Gln Val Ala Leu Leu Cy

#s Asp Pro

385                 3

#90                 3

#95

<210> SEQ ID NO 38

<211> LENGTH: 1812

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 38

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatgatgc gg

#agtttgtg    360

ttctccgtcc tcgtgcggga gagcaaggcc agtgcagtgg gtgatgatga ca

#aggtgtac    420

tacttcttca cggagcgtgc cactgaggag ggctctggca gcttcactca ga

#gccgcagc    480

agtcaccgtg tggcccgtgt ggctcgygtc tgcaagggag acctgggagg ga

#agaagatc    540

ctgcagaaga agtggacttc cttcctgaaa gcccgtctca tctgccacat tc

#cactgtat    600

gagacactgc gtggggtctg cagcctggat gctgaaacct caagccgtac ac

#acttctat    660

gcagccttca cgctgagcac acagtggaag accctggagg cctcagccat ct

#gccgctat    720

gacctggcag agatccaggc tgtctttgca ggaccctata tggaatacca gg

#atggttcc    780

cggcgctggg gtcgctatga gggtggggtg cctgagcccc ggcctggctc gt

#gtatcaca    840

gattcattgc gcagccaagg ctacaattca tcccaagact tgccatccct gg

#tcctggac    900

tttgtaaagt tgcacccact gatggctcgg cccgttgtgc ccacacgtgg ac

#ggcccctg    960

ctgctcaagc gcaacatacg ctacacacac cttacaggga cacctgtcac ca

#cgcctgct   1020

ggacctacct atgacctgct ctttctgggc acagctgatg gctggatcca ca

#aggccgta   1080

gtcctgggct ctgggatgca cattattgaa gagacacaag tgttcaggga gt

#cccagtct   1140

gtggaaaatc tagtcatctc tctattgcag cacagcctct atgtgggggc tc

#ctagcgga   1200

gtcatccagc taccactctc cagctgctcc cgctaccgat cctgctatga ct

#gcatcttg   1260

gcccgagacc cctactgtgg ctgggaccct ggcacccatg cctgcgcagc ag

#ccaccacc   1320

atagccaaca ggtcccaggg aagcaggaca gcactgatac aggacataga ga

#gaggaaat   1380

cgaggctgtg agagcagcag ggatacaggc agggctctgc aggtccatat gg

#gctcaatg   1440

tcaccaccct ctgcatggcc ctgtgtgctg gatggtcctg aaaccagaca ag

#tcctctgc   1500

cagccaccta agccctgcgt acattcacat gcacacatgg aagaatgttt at

#cggctggg   1560

ctgcagtgcc cccaccctca ccttctcctg gtgcattctt gtttcatccc tg

#cttctgga   1620

cttggggtac cctcccaatt gccacatcct atctggtcct cttccccagc cc

#catgtggt   1680

gacctctttg tcaagagctt gggaacgggc cagcctgggg aggtaagact gc

#atcactcc   1740

cctcctctcc cttcctgtgt ggcccttgtg aatcagcctc cccactctcc tt

#ggtcattc   1800

tcaagagtat ga

#

#

#     1812

<210> SEQ ID NO 39

<211> LENGTH: 603

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 39

Met Gln Ser Lys Cys His Gln Lys Gly Lys As

#n Asn Gln Thr Glu Cys

1               5

#                10

#                15

Phe Asn His Val Arg Phe Leu Gln Arg Leu As

#n Ser Thr His Leu Tyr

20

#            25

#            30

Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cy

#s Ala Ala Ile Asp Ala

35

#        40

#        45

Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Gl

#u Gly Lys Glu Lys Cys

50

#    55

#    60

Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Le

#u Ile Ile Asp Gly Gly

65

#70

#75

#80

Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Se

#r Ile Pro Asp Ile Arg

85

#                90

#                95

Arg Ser Arg His Pro His Ser Leu Arg Thr Gl

#u Glu Thr Pro Met His

100

#           105

#           110

Trp Leu Asn Asp Ala Glu Phe Val Phe Ser Va

#l Leu Val Arg Glu Ser

115

#       120

#       125

Lys Ala Ser Ala Val Gly Asp Asp Asp Lys Va

#l Tyr Tyr Phe Phe Thr

130

#   135

#   140

Glu Arg Ala Thr Glu Glu Gly Ser Gly Ser Ph

#e Thr Gln Ser Arg Ser

145                 1

#50                 1

#55                 1

#60

Ser His Arg Val Ala Arg Val Ala Arg Val Cy

#s Lys Gly Asp Leu Gly

165

#               170

#               175

Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr Se

#r Phe Leu Lys Ala Arg

180

#           185

#           190

Leu Ile Cys His Ile Pro Leu Tyr Glu Thr Le

#u Arg Gly Val Cys Ser

195

#       200

#       205

Leu Asp Ala Glu Thr Ser Ser Arg Thr His Ph

#e Tyr Ala Ala Phe Thr

210

#   215

#   220

Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala Se

#r Ala Ile Cys Arg Tyr

225                 2

#30                 2

#35                 2

#40

Asp Leu Ala Glu Ile Gln Ala Val Phe Ala Gl

#y Pro Tyr Met Glu Tyr

245

#               250

#               255

Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr Gl

#u Gly Gly Val Pro Glu

260

#           265

#           270

Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser Le

#u Arg Ser Gln Gly Tyr

275

#       280

#       285

Asn Ser Ser Gln Asp Leu Pro Ser Leu Val Le

#u Asp Phe Val Lys Leu

290

#   295

#   300

His Pro Leu Met Ala Arg Pro Val Val Pro Th

#r Arg Gly Arg Pro Leu

305                 3

#10                 3

#15                 3

#20

Leu Leu Lys Arg Asn Ile Arg Tyr Thr His Le

#u Thr Gly Thr Pro Val

325

#               330

#               335

Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu Le

#u Phe Leu Gly Thr Ala

340

#           345

#           350

Asp Gly Trp Ile His Lys Ala Val Val Leu Gl

#y Ser Gly Met His Ile

355

#       360

#       365

Ile Glu Glu Thr Gln Val Phe Arg Glu Ser Gl

#n Ser Val Glu Asn Leu

370

#   375

#   380

Val Ile Ser Leu Leu Gln His Ser Leu Tyr Va

#l Gly Ala Pro Ser Gly

385                 3

#90                 3

#95                 4

#00

Val Ile Gln Leu Pro Leu Ser Ser Cys Ser Ar

#g Tyr Arg Ser Cys Tyr

405

#               410

#               415

Asp Cys Ile Leu Ala Arg Asp Pro Tyr Cys Gl

#y Trp Asp Pro Gly Thr

420

#           425

#           430

His Ala Cys Ala Ala Ala Thr Thr Ile Ala As

#n Arg Ser Gln Gly Ser

435

#       440

#       445

Arg Thr Ala Leu Ile Gln Asp Ile Glu Arg Gl

#y Asn Arg Gly Cys Glu

450

#   455

#   460

Ser Ser Arg Asp Thr Gly Arg Ala Leu Gln Va

#l His Met Gly Ser Met

465                 4

#70                 4

#75                 4

#80

Ser Pro Pro Ser Ala Trp Pro Cys Val Leu As

#p Gly Pro Glu Thr Arg

485

#               490

#               495

Gln Val Leu Cys Gln Pro Pro Lys Pro Cys Va

#l His Ser His Ala His

500

#           505

#           510

Met Glu Glu Cys Leu Ser Ala Gly Leu Gln Cy

#s Pro His Pro His Leu

515

#       520

#       525

Leu Leu Val His Ser Cys Phe Ile Pro Ala Se

#r Gly Leu Gly Val Pro

530

#   535

#   540

Ser Gln Leu Pro His Pro Ile Trp Ser Ser Se

#r Pro Ala Pro Cys Gly

545                 5

#50                 5

#55                 5

#60

Asp Leu Phe Val Lys Ser Leu Gly Thr Gly Gl

#n Pro Gly Glu Val Arg

565

#               570

#               575

Leu His His Ser Pro Pro Leu Pro Ser Cys Va

#l Ala Leu Val Asn Gln

580

#           585

#           590

Pro Pro His Ser Pro Trp Ser Phe Ser Arg Va

#l

595

#       600

<210> SEQ ID NO 40

<211> LENGTH: 1797

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 40

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatgatgc gg

#agtttgtg    360

ttctccgtcc tcgtgcggga gagcaaggcc agtgcagtgg gtgatgatga ca

#aggtgtac    420

tacttcttca cggagcgtgc cactgaggag ggctctggca gcttcactca ga

#gccgcagc    480

agtcaccgtg tggcccgtgt ggctcgygtc tgcaagggag acctgggagg ga

#agaagatc    540

ctgcagaaga agtggacttc cttcctgaaa gcccgtctca tctgccacat tc

#cactgtat    600

gagacactgc gtggggtctg cagcctggat gctgaaacct caagccgtac ac

#acttctat    660

gcagccttca cgctgagcac acagtggaag accctggagg cctcagccat ct

#gccgctat    720

gacctggcag agatccaggc tgtctttgca ggaccctata tggaatacca gg

#atggttcc    780

cggcgctggg gtcgctatga gggtggggtg cctgagcccc ggcctggctc gt

#gtatcaca    840

gattcattgc gcagccaagg ctacaattca tcccaagact tgccatccct gg

#tcctggac    900

tttgtaaagt tgcacccact gatggctcgg cccgttgtgc ccacacgtgg ac

#ggcccctg    960

ctgctcaagc gcaacatacg ctacacacac cttacaggga cacctgtcac ca

#cgcctgct   1020

ggacctacct atgacctgct ctttctgggc acagctgatg gctggatcca ca

#aggccgta   1080

gtcctgggct ctgggatgca cattattgaa gagacacaag tgttcaggga gt

#cccagtct   1140

gtggaaaatc tagtcatctc tctattgcag cacagcctct atgtgggggc tc

#ctagcgga   1200

gtcatccagc taccactctc cagctgctcc cgctaccgat cctgctatga ct

#gcatcttg   1260

gcccgagacc cctactgtgg ctgggaccct ggcacccatg cctgcgcagc ag

#ccaccacc   1320

atagccaaca ggacagcact gatacaggac atagagagag gaaatcgagg ct

#gtgagagc   1380

agcagggata caggcagggc tctgcaggtc catatgggct caatgtcacc ac

#cctctgca   1440

tggccctgtg tgctggatgg tcctgaaacc agacaagtcc tctgccagcc ac

#ctaagccc   1500

tgcgtacatt cacatgcaca catggaagaa tgtttatcgg ctgggctgca gt

#gcccccac   1560

cctcaccttc tcctggtgca ttcttgtttc atccctgctt ctggacttgg gg

#taccctcc   1620

caattgccac atcctatctg gtcctcttcc ccagccccat gtggtgacct ct

#ttgtcaag   1680

agcttgggaa cgggccagcc tggggaggta agactgcatc actcccctcc tc

#tcccttcc   1740

tgtgtggccc ttgtgaatca gcctccccac tctccttggt cattctcaag ag

#tatga      1797

<210> SEQ ID NO 41

<211> LENGTH: 598

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 41

Met Gln Ser Lys Cys His Gln Lys Gly Lys As

#n Asn Gln Thr Glu Cys

1               5

#                10

#                15

Phe Asn His Val Arg Phe Leu Gln Arg Leu As

#n Ser Thr His Leu Tyr

20

#            25

#            30

Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cy

#s Ala Ala Ile Asp Ala

35

#        40

#        45

Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Gl

#u Gly Lys Glu Lys Cys

50

#    55

#    60

Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Le

#u Ile Ile Asp Gly Gly

65

#70

#75

#80

Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Se

#r Ile Pro Asp Ile Arg

85

#                90

#                95

Arg Ser Arg His Pro His Ser Leu Arg Thr Gl

#u Glu Thr Pro Met His

100

#           105

#           110

Trp Leu Asn Asp Ala Glu Phe Val Phe Ser Va

#l Leu Val Arg Glu Ser

115

#       120

#       125

Lys Ala Ser Ala Val Gly Asp Asp Asp Lys Va

#l Tyr Tyr Phe Phe Thr

130

#   135

#   140

Glu Arg Ala Thr Glu Glu Gly Ser Gly Ser Ph

#e Thr Gln Ser Arg Ser

145                 1

#50                 1

#55                 1

#60

Ser His Arg Val Ala Arg Val Ala Arg Val Cy

#s Lys Gly Asp Leu Gly

165

#               170

#               175

Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr Se

#r Phe Leu Lys Ala Arg

180

#           185

#           190

Leu Ile Cys His Ile Pro Leu Tyr Glu Thr Le

#u Arg Gly Val Cys Ser

195

#       200

#       205

Leu Asp Ala Glu Thr Ser Ser Arg Thr His Ph

#e Tyr Ala Ala Phe Thr

210

#   215

#   220

Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala Se

#r Ala Ile Cys Arg Tyr

225                 2

#30                 2

#35                 2

#40

Asp Leu Ala Glu Ile Gln Ala Val Phe Ala Gl

#y Pro Tyr Met Glu Tyr

245

#               250

#               255

Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr Gl

#u Gly Gly Val Pro Glu

260

#           265

#           270

Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser Le

#u Arg Ser Gln Gly Tyr

275

#       280

#       285

Asn Ser Ser Gln Asp Leu Pro Ser Leu Val Le

#u Asp Phe Val Lys Leu

290

#   295

#   300

His Pro Leu Met Ala Arg Pro Val Val Pro Th

#r Arg Gly Arg Pro Leu

305                 3

#10                 3

#15                 3

#20

Leu Leu Lys Arg Asn Ile Arg Tyr Thr His Le

#u Thr Gly Thr Pro Val

325

#               330

#               335

Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu Le

#u Phe Leu Gly Thr Ala

340

#           345

#           350

Asp Gly Trp Ile His Lys Ala Val Val Leu Gl

#y Ser Gly Met His Ile

355

#       360

#       365

Ile Glu Glu Thr Gln Val Phe Arg Glu Ser Gl

#n Ser Val Glu Asn Leu

370

#   375

#   380

Val Ile Ser Leu Leu Gln His Ser Leu Tyr Va

#l Gly Ala Pro Ser Gly

385                 3

#90                 3

#95                 4

#00

Val Ile Gln Leu Pro Leu Ser Ser Cys Ser Ar

#g Tyr Arg Ser Cys Tyr

405

#               410

#               415

Asp Cys Ile Leu Ala Arg Asp Pro Tyr Cys Gl

#y Trp Asp Pro Gly Thr

420

#           425

#           430

His Ala Cys Ala Ala Ala Thr Thr Ile Ala As

#n Arg Thr Ala Leu Ile

435

#       440

#       445

Gln Asp Ile Glu Arg Gly Asn Arg Gly Cys Gl

#u Ser Ser Arg Asp Thr

450

#   455

#   460

Gly Arg Ala Leu Gln Val His Met Gly Ser Me

#t Ser Pro Pro Ser Ala

465                 4

#70                 4

#75                 4

#80

Trp Pro Cys Val Leu Asp Gly Pro Glu Thr Ar

#g Gln Val Leu Cys Gln

485

#               490

#               495

Pro Pro Lys Pro Cys Val His Ser His Ala Hi

#s Met Glu Glu Cys Leu

500

#           505

#           510

Ser Ala Gly Leu Gln Cys Pro His Pro His Le

#u Leu Leu Val His Ser

515

#       520

#       525

Cys Phe Ile Pro Ala Ser Gly Leu Gly Val Pr

#o Ser Gln Leu Pro His

530

#   535

#   540

Pro Ile Trp Ser Ser Ser Pro Ala Pro Cys Gl

#y Asp Leu Phe Val Lys

545                 5

#50                 5

#55                 5

#60

Ser Leu Gly Thr Gly Gln Pro Gly Glu Val Ar

#g Leu His His Ser Pro

565

#               570

#               575

Pro Leu Pro Ser Cys Val Ala Leu Val Asn Gl

#n Pro Pro His Ser Pro

580

#           585

#           590

Trp Ser Phe Ser Arg Val

595

<210> SEQ ID NO 42

<211> LENGTH: 2235

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 42

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatgatgc gg

#agtttgtg    360

ttctccgtcc tcgtgcggga gagcaaggcc agtgcagtgg gtgatgatga ca

#aggtgtac    420

tacttcttca cggagcgtgc cactgaggag ggctctggca gcttcactca ga

#gccgcagc    480

agtcaccgtg tggcccgtgt ggctcgygtc tgcaagggag acctgggagg ga

#agaagatc    540

ctgcagaaga agtggacttc cttcctgaaa gcccgtctca tctgccacat tc

#cactgtat    600

gagacactgc gtggggtctg cagcctggat gctgaaacct caagccgtac ac

#acttctat    660

gcagccttca cgctgagcac acagtggaag accctggagg cctcagccat ct

#gccgctat    720

gacctggcag agatccaggc tgtctttgca ggaccctata tggaatacca gg

#atggttcc    780

cggcgctggg gtcgctatga gggtggggtg cctgagcccc ggcctggctc gt

#gtatcaca    840

gattcattgc gcagccaagg ctacaattca tcccaagact tgccatccct gg

#tcctggac    900

tttgtaaagt tgcacccact gatggctcgg cccgttgtgc ccacacgtgg ac

#ggcccctg    960

ctgctcaagc gcaacatacg ctacacacac cttacaggga cacctgtcac ca

#cgcctgct   1020

ggacctacct atgacctgct ctttctgggc acagctgatg gctggatcca ca

#aggccgta   1080

gtcctgggct ctgggatgca cattattgaa gagacacaag tgttcaggga gt

#cccagtct   1140

gtggaaaatc tagtcatctc tctattgcag cacagcctct atgtgggggc tc

#ctagcgga   1200

gtcatccagc taccactctc cagctgctcc cgctaccgat cctgctatga ct

#gcatcttg   1260

gcccgagacc cctactgtgg ctgggaccct ggcacccatg cctgcgcagc ag

#ccaccacc   1320

atagccaaca ggtcccaggg aagcaggaca gcactgatac aggacataga ga

#gaggaaat   1380

cgaggctgtg agagcagcag ggatacaggg ccaccaccac cactgaagac cc

#gctctgtg   1440

ctccggggtg atgatgtcct cctgccctgt gaccagccat ccaacctggc cc

#gggccttg   1500

tggctactca atgggagcat gggcctgagc gatgggcagg gtggctaccg tg

#tgggcgtg   1560

gacgggctgc tggttacaga tgcacagcct gagcacagtg gcaactatgg ct

#gctatgcc   1620

gaggaaaatg gcctccgcac cctgctggcc tcctatagtc tcacagtccg gc

#cagccact   1680

cctgccccag ctccaaaagc ccctgccaca cctggggcac agctggcacc tg

#atgtgaga   1740

ctgctctatg tgctagccat tgccgcgctt ggtggccyct gcctcatcct gg

#cctcctcc   1800

ctcctctatg tggcctgtct gcgggaaggc agacgagggc gccgacggaa at

#actcactg   1860

ggtcgggcca gccgggcagg aggatctgcg gtgcaactgc agacagtctc ag

#gccagtgt   1920

cctggagagg aagatgaggg tgatgatgag ggggctgggg gcctggaggg ca

#gctgtctc   1980

cagatcatcc ctggggaggg agccccagcc ccaccacccc caccgccccc ac

#cgccaccg   2040

gctgagctga ccaatggctt ggtggcactg cccagccggc tgcggaggat ga

#atggcaat   2100

agctatgtgc ttctgaggca gagcaacaat ggagtaccag cagggccctg ct

#ccttcgcc   2160

gaggaactca gccgcatcct ggaaaaaagg aagcacacgc agctcgtgga gc

#agctagat   2220

gagagctctg tctga

#

#

#  2235

<210> SEQ ID NO 43

<211> LENGTH: 744

<212> TYPE: PRT

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 43

Met Gln Ser Lys Cys His Gln Lys Gly Lys As

#n Asn Gln Thr Glu Cys

1               5

#                10

#                15

Phe Asn His Val Arg Phe Leu Gln Arg Leu As

#n Ser Thr His Leu Tyr

20

#            25

#            30

Ala Cys Gly Thr His Ala Phe Gln Pro Leu Cy

#s Ala Ala Ile Asp Ala

35

#        40

#        45

Glu Ala Phe Thr Leu Pro Thr Ser Phe Glu Gl

#u Gly Lys Glu Lys Cys

50

#    55

#    60

Pro Tyr Asp Pro Ala Arg Gly Phe Thr Gly Le

#u Ile Ile Asp Gly Gly

65

#70

#75

#80

Leu Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Se

#r Ile Pro Asp Ile Arg

85

#                90

#                95

Arg Ser Arg His Pro His Ser Leu Arg Thr Gl

#u Glu Thr Pro Met His

100

#           105

#           110

Trp Leu Asn Asp Ala Glu Phe Val Phe Ser Va

#l Leu Val Arg Glu Ser

115

#       120

#       125

Lys Ala Ser Ala Val Gly Asp Asp Asp Lys Va

#l Tyr Tyr Phe Phe Thr

130

#   135

#   140

Glu Arg Ala Thr Glu Glu Gly Ser Gly Ser Ph

#e Thr Gln Ser Arg Ser

145                 1

#50                 1

#55                 1

#60

Ser His Arg Val Ala Arg Val Ala Arg Val Cy

#s Lys Gly Asp Leu Gly

165

#               170

#               175

Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr Se

#r Phe Leu Lys Ala Arg

180

#           185

#           190

Leu Ile Cys His Ile Pro Leu Tyr Glu Thr Le

#u Arg Gly Val Cys Ser

195

#       200

#       205

Leu Asp Ala Glu Thr Ser Ser Arg Thr His Ph

#e Tyr Ala Ala Phe Thr

210

#   215

#   220

Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala Se

#r Ala Ile Cys Arg Tyr

225                 2

#30                 2

#35                 2

#40

Asp Leu Ala Glu Ile Gln Ala Val Phe Ala Gl

#y Pro Tyr Met Glu Tyr

245

#               250

#               255

Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr Gl

#u Gly Gly Val Pro Glu

260

#           265

#           270

Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser Le

#u Arg Ser Gln Gly Tyr

275

#       280

#       285

Asn Ser Ser Gln Asp Leu Pro Ser Leu Val Le

#u Asp Phe Val Lys Leu

290

#   295

#   300

His Pro Leu Met Ala Arg Pro Val Val Pro Th

#r Arg Gly Arg Pro Leu

305                 3

#10                 3

#15                 3

#20

Leu Leu Lys Arg Asn Ile Arg Tyr Thr His Le

#u Thr Gly Thr Pro Val

325

#               330

#               335

Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu Le

#u Phe Leu Gly Thr Ala

340

#           345

#           350

Asp Gly Trp Ile His Lys Ala Val Val Leu Gl

#y Ser Gly Met His Ile

355

#       360

#       365

Ile Glu Glu Thr Gln Val Phe Arg Glu Ser Gl

#n Ser Val Glu Asn Leu

370

#   375

#   380

Val Ile Ser Leu Leu Gln His Ser Leu Tyr Va

#l Gly Ala Pro Ser Gly

385                 3

#90                 3

#95                 4

#00

Val Ile Gln Leu Pro Leu Ser Ser Cys Ser Ar

#g Tyr Arg Ser Cys Tyr

405

#               410

#               415

Asp Cys Ile Leu Ala Arg Asp Pro Tyr Cys Gl

#y Trp Asp Pro Gly Thr

420

#           425

#           430

His Ala Cys Ala Ala Ala Thr Thr Ile Ala As

#n Arg Ser Gln Gly Ser

435

#       440

#       445

Arg Thr Ala Leu Ile Gln Asp Ile Glu Arg Gl

#y Asn Arg Gly Cys Glu

450

#   455

#   460

Ser Ser Arg Asp Thr Gly Pro Pro Pro Pro Le

#u Lys Thr Arg Ser Val

465                 4

#70                 4

#75                 4

#80

Leu Arg Gly Asp Asp Val Leu Leu Pro Cys As

#p Gln Pro Ser Asn Leu

485

#               490

#               495

Ala Arg Ala Leu Trp Leu Leu Asn Gly Ser Me

#t Gly Leu Ser Asp Gly

500

#           505

#           510

Gln Gly Gly Tyr Arg Val Gly Val Asp Gly Le

#u Leu Val Thr Asp Ala

515

#       520

#       525

Gln Pro Glu His Ser Gly Asn Tyr Gly Cys Ty

#r Ala Glu Glu Asn Gly

530

#   535

#   540

Leu Arg Thr Leu Leu Ala Ser Tyr Ser Leu Th

#r Val Arg Pro Ala Thr

545                 5

#50                 5

#55                 5

#60

Pro Ala Pro Ala Pro Lys Ala Pro Ala Thr Pr

#o Gly Ala Gln Leu Ala

565

#               570

#               575

Pro Asp Val Arg Leu Leu Tyr Val Leu Ala Il

#e Ala Ala Leu Gly Gly

580

#           585

#           590

Leu Cys Leu Ile Leu Ala Ser Ser Leu Leu Ty

#r Val Ala Cys Leu Arg

595

#       600

#       605

Glu Gly Arg Arg Gly Arg Arg Arg Lys Tyr Se

#r Leu Gly Arg Ala Ser

610

#   615

#   620

Arg Ala Gly Gly Ser Ala Val Gln Leu Gln Th

#r Val Ser Gly Gln Cys

625                 6

#30                 6

#35                 6

#40

Pro Gly Glu Glu Asp Glu Gly Asp Asp Glu Gl

#y Ala Gly Gly Leu Glu

645

#               650

#               655

Gly Ser Cys Leu Gln Ile Ile Pro Gly Glu Gl

#y Ala Pro Ala Pro Pro

660

#           665

#           670

Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Le

#u Thr Asn Gly Leu Val

675

#       680

#       685

Ala Leu Pro Ser Arg Leu Arg Arg Met Asn Gl

#y Asn Ser Tyr Val Leu

690

#   695

#   700

Leu Arg Gln Ser Asn Asn Gly Val Pro Ala Gl

#y Pro Cys Ser Phe Ala

705                 7

#10                 7

#15                 7

#20

Glu Glu Leu Ser Arg Ile Leu Glu Lys Arg Ly

#s His Thr Gln Leu Val

725

#               730

#               735

Glu Gln Leu Asp Glu Ser Ser Val

740

<210> SEQ ID NO 44

<211> LENGTH: 2220

<212> TYPE: DNA

<213> ORGANISM: homo sapiens

<400> SEQUENCE: 44

atgcaaagca aatgtcatca aaaagggaaa aacaaccaga cggagtgctt ta

#accatgtg     60

cggttcctgc agcggctcaa ttctacccac ctctatgcat gtgggactca cg

#ccttccag    120

cccctctgtg cagccattga tgctgaggcc ttcaccttgc caaccagctt cg

#aggagggg    180

aaggagaagt gtccttatga cccagcccgt ggcttcacag gcctcatcat tg

#atggaggc    240

ctctacacag ccactaggta tgaattccgg agcattcctg acatccgccg ga

#gccgccac    300

ccacactccc tgagaactga ggagacacca atgcattggc tcaatgatgc gg

#agtttgtg    360

ttctccgtcc tcgtgcggga gagcaaggcc agtgcagtgg gtgatgatga ca

#aggtgtac    420

tacttcttca cggagcgtgc cactgaggag ggctctggca gcttcactca ga

#gccgcagc    480

agtcaccgtg tggcccgtgt ggctcgygtc tgcaagggag acctgggagg ga

#agaagatc    540

ctgcagaaga agtggacttc cttcctgaaa gcccgtctca tctgccacat tc

#cactgtat    600

gagacactgc gtggggtctg cagcctggat gctgaaacct caagccgtac ac

#acttctat    660

gcagccttca cgctgagcac acagtggaag accctggagg cctcagccat ct

#gccgctat    720

gacctggcag agatccaggc tgtctttgca ggaccctata tggaatacca gg

#atggttcc    780

cggcgctggg gtcgctatga gggtggggtg cctgagcccc ggcctggctc gt

#gtatcaca    840

gattcattgc gcagccaagg ctacaattca tcccaagact tgccatccct gg

#tcctggac    900

tttgtaaagt tgcacccact gatggctcgg cccgttgtgc ccacacgtgg ac

#ggcccctg    960

ctgctcaagc gcaacatacg ctacacacac cttacaggga cacctgtcac ca

#cgcctgct   1020

ggacctacct atgacctgct ctttctgggc acagctgatg gctggatcca ca

#aggccgta   1080

gtcctgggct ctgggatgca cattattgaa gagacacaag tgttcaggga gt

#cccagtct   1140

gtggaaaatc tagtcatctc tctattgcag cacagcctct atgtgggggc tc

#ctagcgga   1200

gtcatccagc taccactctc cagctgctcc cgctaccgat cctgctatga ct

#gcatcttg   1260

gcccgagacc cctactgtgg ctgggaccct ggcacccatg cctgcgcagc ag

#ccaccacc   1320

atagccaaca ggacagcact gatacaggac atagagagag gaaatcgagg ct

#gtgagagc   1380

agcagggata cagggccacc accaccactg aagacccgct ctgtgctccg gg

#gtgatgat   1440

gtcctcctgc cctgtgacca gccatccaac ctggcccggg ccttgtggct ac

#tcaatggg   1500

agcatgggcc tgagcgatgg gcagggtggc taccgtgtgg gcgtggacgg gc

#tgctggtt   1560

acagatgcac agcctgagca cagtggcaac tatggctgct atgccgagga aa

#atggcctc   1620

cgcaccctgc tggcctccta tagtctcaca gtccggccag ccactcctgc cc

#cagctcca   1680