The invention relates to a process for preparing triphendioxazine compounds by cyclizing the intermediates (IV) in the presence of manganese oxide and sulfuric acid to form compounds of the general formula (I) a process for condensing compounds of the general formula (II) with compounds of the general formula (III) to form the chlorine-free intermediates (IV) and also compounds of the general formula (IV).

Description

11 parts

›FIELD OF THE INVENTION

This invention provides a particularly advantageous process for preparing triphendioxazine compounds and particularly advantageous intermediates.

›BACKGROUND OF THE INVENTION

European patent application EP 0889046 A1 describes symmetrically disubstituted triphendioxazine compounds of the following general formula (I)

where the rings marked A are inter alia linearly fused in positions 2, 3 and 9, 10 with rings having complementary members including of the formulae —NR 1 —(CO) m —NH— and —NR 1 —(CO) m —O—; where R 1 is hydrogen, C 1-4 alkyl or phenyl, preferably hydrogen, methyl or ethyl; and m is 1 or 2.

The preparative process disclosed in EP 0889046 A1 proceeds from intermediates, i.e. amino compounds, which are ortho-substituted by an alkoxy group and obtainable only by a relatively complex synthesis. The process described is characterized by the use of 2,3,5,6-tetrachloro-1,4-benzoquinone and leads to intermediates which are chlorinated on the central ring. The ring closure reaction proceeds by dechlorination and leads to the chlorine-free triphendioxazine compounds of the general formula (I). The condensation reaction does not generally lead completely to the chlorine-free compounds of the formula (I); it virtually always by-produces a certain amount of monochloro and dichloro compounds.

›SUMMARY OF THE INVENTION

It is an object of the present invention to provide a process which proceeds from readily available intermediates that are not chlorinated on the central ring and leads via nonchlorinated intermediates to the desired triphendioxazine compounds which are completely chlorine-free on the central ring.

›DESCRIPTION OF THE PREFERRED EMBODIMENTS · 1 of 2

It was surprisingly determined that even amino compounds which are not substituted in the ortho position are useful as intermediates, provided the cyclization taking place following the reaction with a benzoquinone is carried out according to the invention using manganese dioxide and 80 to 100% strength, preferably 90 to 95% strength, sulfuric acid. It is also unexpected that the cyclization is not accompanied by a sulfonation on the central ring, but provides the triphendioxazine compounds of the general formula (I) directly.

The reaction of 1 mol of a compound of the general formula (II)

where R 3 is hydrogen, C 1-10 alkoxy, halogen or hydroxyl, with 2 mol of a compound of the general formula (III) (=intermediates)

where the ring marked A is linearly fused in position 3, 4 with a ring having a complementary member of the formula —NR 1 (CO) m —NR 2 or —O—CO—NR 2 ; m is 1 or 2; and R 1 and/or R 2 are each independently hydrogen, a C 1-8 alkyl radical, a substituted or unsubstituted phenyl, benzyl, naphthyl or benzanilide radical, a substituted or unsubstituted C 5-6 cycloalkyl radical or a radical of the formula

is followed as a characterizing step by a cyclization carried out using manganese dioxide(MnO 2 ) and 80 to 100% strength, preferably 90 to 95% strength, sulfuric acid.

Preferred compounds of the general formula (III) are

where R 1 and R 2 are each as defined above.

The condensation reaction of compound (II) with compound (III) or (IIIa-d) is carried out in a solvent in the presence of an inorganic or organic acid as a catalyst between 50 and 160° C. It may also be carried out in water or glacial acetic acid. The condensation reaction leads to intermediates of the general formula (IV), where the rings marked A are defined as above for formula (III).

The advantage of this process is that it is possible to proceed from the intermediates (III) or (IIIa), (IIIb), (IIIc) and (IIId) which, unlike the amino compounds bearing an alkoxy group in the ortho position, are relatively simple to obtain. Starting compound (II) is preferably 2,5-dihydroxy-1,4-benzoquinone.

Preferred solvents for the condensation reaction are high-boiling solvents such as, for example, N-methylpyrrolidone, dimethylformamide or orthodichlorobenzene.

The preparation of the intermediates (IIIa), (IIIb), (IIIc) and (IIId) is described in EP 0911337 A1.

Preferably R 1 and R 2 are each independently hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclohexyl, a substituted or unsubstituted benzanilide radical, naphthyl, a radical of the formula

an unsubstituted phenyl radical or a phenyl radical which is substituted by one or more substituents selected from the group consisting of halogen, preferably chlorine, nitro, phenyl, C 1-8 -alkyl, preferably C 1-4 -alkyl, and C 1-2 -alkoxy.

The abovementioned substituted phenyl radical in the definition of R 1 and R 2 is preferably a radical of the formulae (a) to (q)

The abovementioned substituted benzanilide radical in the definition of R 1 and R 2 is preferably a radical of the formulae (r) and (s)

Particularly preferred compounds of the formula (III) are compounds conforming to the following formulae (1) to (18):

Triphendioxazine compounds of the formula (I) which are prepared by the process according to the invention are used as pigments.

The pigments prepared according to the process of the invention are very useful for coloring plastic materials, by which are meant solvent-free and solvent-containing materials comprising plastics or synthetic resins (in oil-based or water-based paints, in coating materials of various kinds, for spin dyeing viscose or cellulose acetate or for pigmenting plastics, for example polyamide, polyethylene, polystyrene, polyvinyl chloride, rubber and artificial leather). They may also be used in printing inks for the graphical industry, for the coloring of paper materials, for the coating of textiles or for pigment printing.

They may also be used in cosmetics.

The colorations obtained are notable for their excellent heat, light and weather fastness, chemical resistance, color strength and very good application properties, for example crystallization resistance and dispersing fastness, and especially for their fastness to migration, bleeding, overcoating and solvents.

In addition, the pigments prepared according to the process of the invention are also useful as colorants in electrophotographic toners and developers, for example one- or two-component powder toners (also known as one- or two-component developers), magnetic toners, liquid toners, polymerization toners and further specialty toners (ref.: L. B. Schein, “Electrophotography and Development Physics”; Springer Series in Electrophysics 14, Springer Verlag, 2 nd edition, 1992).

Typical toner binders include addition polymerization, polyaddition and polycondensation resins, such as styrene, styrene acrylate, styrene butadiene, acrylate, polyester, phenolic and epoxy resins, polysulfones, polyurethanes, individually or in combination, and also polyethylene and polypropylene, in or to which further ingredients, such as charge control agents, waxes or flow auxiliaries, may be present or added subsequently.

A further application area for pigments prepared according to the process of the invention is their use as colorants in powders and powder coating materials, especially triboelectrically or electrokinetically sprayed powder coating materials, which are used to coat the surfaces of articles made, for example, of metal, wood, plastic, glass, ceramic, concrete, textile material, paper or rubber (J. F. Hughes, “Electrostatics Powder Coating”, Research Studies Press, John Wiley & Sons, 1984).

Powder coating resins employed are typically epoxy resins, carboxyl- and hydroxyl-containing polyester resins, polyurethane resins and acrylic resins together with customary curing agents. Combinations of resins are also used. For instance, epoxy resins are frequently used in combination with carboxyl- and hydroxyl-containing polyester resins. Typical curing agent components (depending on the resins system) are, for example, acid anhydrides, imidazoles and dicyandiamide and derivatives thereof, blocked isocyanates, bisacylurethanes, phenolic and melamine resins, triglycidyl isocyanurates, oxazolines and dicarboxylic acids.

›DESCRIPTION OF THE PREFERRED EMBODIMENTS · 2 of 2

The pigments prepared according to the process of the invention are also useful as colorants in inkjet inks, both aqueous and nonaqueous, and in those inks which operate according to the hot-melt process.

›EXAMPLES

In the examples which follow, parts and percentages are by weight. The temperatures are reported in degrees Celsius. One part by volume corresponds to the volume of one part by weight of water.

›Examples5

›Example 1

3,11-Di-p-tolyldiimidazo(4,5-b:4′,5′-m)triphendioxazine-2,10-dione

120 parts of 1-(p-tolyl)-1,3-dihydro-5-aminobenzimidazol-2-one and 35 parts of 2,5-dihydroxy-1, 4-benzoquinone are introduced into 500 parts by volume of glacial acetic acid. The stirred mixture is heated to 110° C., is cooled and the crystallized intermediate is filtered off, washed with 250 parts of glacial acetic acid and then with 500 parts of water and dried.

Microanalysis: calc. C 70.09 H 4.5 N 14.42 O 10.98%; found C 69.9 H 4.4 N 14.4 O 11.1%.

81 parts of this intermediate are introduced into 400 parts of H 2 SO 4 (90%) with ice cooling. 29.6 parts of MnO 2 (88%) are then added over 3 hours and the mixture is warmed to room temperature over 24 hours. 63 parts of water are added to dilute the condensation mixture to 80% and it is then admixed with 5.1 parts of H 2 O 2 with cooling. The pigment obtained is filtered off and washed with 300 parts of 80% H 2 SO 4 , then with 300 parts of 50% H 2 SO 4 and acid-free with 4000 parts of water. The moist pressed cake is then suspended in 500 parts of dimethylacetamide and the remaining water is distilled off at 100-150° C. After cooling to 120° C. the pigment is filtered, then washed with 800 parts of hot dimethylacetamide at 120° C. and then with 400 parts of water and dried at 80° C. under reduced pressure to obtain 60 parts of a pigment of the above formula, which colors plastics in reddish violet shades possessing excellent migration fastness.

NMR 1 H (360 MHz, D6-DMSO): 2.4 (s, 6H, CH3), 6.3 (s, 2H, aromatic CH), 6.5 (s, 2H, aromatic CH), 6.7 (s, 2H, aromatic CH), 7.3 (dd, 8H, tolyl CH).

Microanalysis: calc. C 70.58 H 3.83 N 14.52%; found C 69.2 H 4.0 N 14.6%.

›Example 2

3,11-Dimethyldiimidazo(4,5-b:4′,5′-m)triphendioxazine-2,10-dione

75 parts of 1-methyl-1,3-dihydro-5-aminobenzimidazol-2-one and 35 parts of 2,5-dihydroxy-1,4-benzoquinone are introduced into 400 parts by volume of glacial acetic acid. The stirred mixture is heated to the boil and cooled and the crystallized intermediate is filtered off, washed with 200 parts of glacial acetic acid and then with water and dried.

50 parts of this intermediate are introduced into 500 parts of H 2 SO 4 (95%) with ice cooling. 13 parts of MnO 2 are then added over 3 hours and the mixture is warmed to room temperature over 24 hours. 94 parts of water are added to dilute the condensation mixture to 80% and it is then admixed with 3.6 parts of H 2 O 2 with cooling. The pigment obtained is filtered off and washed with 600 parts of 80% H 2 SO 4 , then with 300 parts of 50% H 2 SO 4 and acid-free with 4000 parts of water. The moist pressed cake is then suspended in 500 parts of dimethylacetamide and the remaining water is distilled off at 100-150° C. After cooling to 120° C. the pigment is filtered, then washed with 800 parts of hot dimethylacetamide at 120° C. and then with 400 parts of water and dried at 80° C. under reduced pressure.

The resultant pigment of the above formula colors plastics in reddish violet shades having excellent migration and solvent fastness.

›Example 3

3,11-Diphenyldiimidazo(4,5-b:4′,5′-m)triphendioxazine-2,10-dione

128 parts of 1-(phenyl)-1,3-dihydro-5-aminobenzimidazol-2-one and 35 parts of 2,5-dihydroxy-1,4-benzoquinone are introduced into 400 parts by volume of glacial acetic acid.

The stirred mixture is heated to 110° C. and cooled and the crystallized intermediate is filtered off, washed with 300 parts of glacial acetic acid and then with 500 parts of water and dried.

NMR 1 H (360 MHz, D 6 -DMSO): 5.8 (s, 2H, CH quinone), 7.15 (s, 4H, aromatic CH), 7.25 (s, 2H, aromatic CH), 7.5 (m, 2H, aromatic CH), 7.7 (m, 8H, aromatic CH), 9.3 (s, 2H, NH), 11.2 (s, 2H, NH).

Microanalysis: calc. C 69.3 H 4.0 N 15.15 O 11.54%; found C 68.4 H 3.9 N 15.5 O 11.7%.

86 parts of this intermediate are introduced into 500 parts of H 2 SO 4 (90%) with ice cooling. 29.6 parts of MnO 2 (88%) are then added over 3 hours and the mixture is warmed to room temperature over 24 hours. 63 parts of water are added to dilute the condensation mixture to 80% and it is then admixed with 5.1 parts of H 2 O 2 with cooling. The pigment obtained is filtered off and washed with 300 parts of 80% H 2 SO 4 , then with 300 parts of 50% H 2 SO 4 and acid-free with 4000 parts of water. The moist pressed cake is then suspended in 500 parts of dimethylacetamide and the remaining water is distilled off at 100-150° C. After cooling to 120° C. the pigment is filtered, then washed with 800 parts of hot dimethylacetamide at 120° C. and then with 400 parts of water and dried at 80° C. under reduced pressure to obtain 60 parts of a pigment of the above formula, which colors plastics in violet shades possessing excellent migration fastness.

NMR 1 H (360 MHz, D 6 -DMSO): 6.3 (s, 2H, aromatic CH), 6.6 (s, 2H, aromatic CH), 6.75 (s, 2H, aromatic CH), 7.3 (m, 2H, phenyl CH), 7.5 (m, 8H, phenyl CH),

Microanalysis. C 69.8 H 3.3 N 15.27 O 11.62%; Found C 67.3 H 3.4 N 15.2 O 12.3%.

›Example 4

3,11-Di-(P-chlorophenyl)-diimidazo(4,5-b:4′,5′-m)triphendioxazine-2,10-dione

145 parts of 1-(p-chlorophenyl)-1,3-dihydro-5-aminobenzimidazol-2-one and 35 parts of 2,5-dihydroxy-1,4-benzoquinone are introduced into 400 parts by volume of glacial acetic acid. The stirred mixture is heated to 110° C. and cooled and the crystallized intermediate is filtered off, washed with 300 parts of glacial acetic acid and then with 500 parts of water and dried.

86 parts of this intermediate are introduced into 500 parts of H 2 SO 4 (90%) with ice cooling. 29.6 parts of MnO 2 (88%) are then added over 3 hours and the mixture is warmed to room temperature over 24 hours. 63 parts of water are added to dilute the condensation mixture to 80% and it is then admixed with 5.1 parts of H 2 O 2 with cooling. The pigment obtained is filtered off and washed with 300 parts of 80% H 2 SO 4 , then with 300 parts of 50% H 2 SO 4 and acid-free with 4000 parts of water. The moist pressed cake is then suspended in 500 parts of dimethylacetamide and the remaining water is distilled off at 100-150° C. After cooling to 120° C. the pigment is filtered, then washed with 800 parts of hot dimethylacetamide at 120° C. and then with 400 parts of water and dried at 80° C. under reduced pressure to obtain 60 parts of a pigment of the above formula, which colors plastics in reddish violet shades possessing excellent migration fastness.

NMR 1 H (360 MHz, D 6 -DMSO): 6.3 (s, 2H, aromatic CH), 6.6 (s, 2H, aromatic CH), 6.8 (s, 2H, aromatic CH), 7.5 (dd, 8H, phenyl CH). μA: calc.: C 62.05 H 2.6 N 13.57%; found: C 61.9 H 2.9 N 13.3%.

›Example 5

3,11-Diethyldiimidazo(4,5-b:4′,5′-m)triphendioxazine-2,10-dione

75 parts of 1-ethyl-5-aminobenzimidazol-2-one and 35 parts of 2,5-dihydroxy -1,4 -benzoquinone are introduced into 400 parts by volume of glacial acetic acid. The stirred mixture is heated to 110° C. and cooled and the crystallized intermediate is filtered off, washed with 200 parts of glacial acetic acid and then with water and dried.

Or:

75 parts of 1-ethyl-5-aminobenzimidazol-2-one and 45 parts of 2,5-dimethoxy-1,4-benzoquinone are introduced into 400 parts by volume of glacial acetic acid. The stirred mixture is heated to 110° C. and cooled and the crystallized intermediate is filtered off, washed with 200 parts of glacial acetic acid and then with water and dried.

Or:

75 parts of 1-ethyl-5-aminobenzimidazol-2-one are introduced into 400 parts by volume of 10% concentrated hydrochloric acid and 81 parts of 1,4-benzoquinone are subsequently added over 2 hours. The stirred mixture is heated to 110° C. and cooled and the crystallized intermediate is filtered off, washed with 800 parts of warm 10% concentrated hydrochloric acid then with warm water and dried.

50 parts of this intermediate are introduced into 300 parts of H 2 SO 4 (95%) with ice cooling. 13 parts of MnO 2 are then added over 3 hours and the mixture is warmed to room temperature over 24 hours. 94 parts of water are added to dilute the condensation mixture to 80% and it is then admixed with 3.6 parts of H 2 O 2 with cooling. The pigment obtained is filtered off and washed with 600 parts of 80% H 2 SO 4 , then with 300 parts of 50% H 2 SO 4 and acid-free with 4000 parts of water. The moist pressed cake is then suspended in 500 parts of dimethylacetamide and the remaining water is distilled off at 100-150° C. After cooling to 120° C. the pigment is filtered, then washed with 800 parts of hot dimethylacetamide at 120° C. and then with 400 parts of water and dried at 80° C. under reduced pressure.

NMR 1 H (360 MHz, D6-DMSO): 1.11 (t, 6H, CH 3 ), 3.71 (q, 4H, CH 2 ), 6.25 (s, 2H, aromatic CH), 6.5 (s, 2H, aromatic CH), 6.6 (s, 2H, aromatic CH).

Microanalysis. C 63.4 H 4.0 N 18.5 O 14.1%; Found C 62.5 H 3.7 N 18.8 O 14.1%.

The resultant pigment of the above formula colors plastics in reddish blue shades having excellent migration and solvent fastness.

Claims as granted

11 claims

Classifications

14 codes

IPC · International Patent Classification

Section C — Chemistry; metallurgy

C09D7/41
C09D7/40
C09D11/00
C09B19/02
C09D201/00
C07B61/00
C08K5/357
C08L101/00
C07D498/22
C07D489/04

Section G — Physics

G03G9/09

USPC · US Patent Classification

544/74544/738/506

Claim changes

Soon

Coming soonHow the claims changed between publication and grant

See which claims were amended, added or cancelled during examination, with every added and removed word marked.

AmendedAddedCancelledUnchanged

The published claims of this application are not paired with the granted ones in what we hold.

File wrapper

⤢ drag to zoom

USPTOApplicanthover for detail · click to open

Pendency

1.9 y

693 days filing → grant

Office actions

non-final + final

Responses

no RCE

Examiner

Richard L. Raymond

art unit 1755 · TC 1700

Law firm

Law firm · Log in to unlock

Citations: 15 back · 1 forward

See the full prosecution history — every USPTO and applicant action on this file, in order.

Documents

Log in to open the documents of this file: the application as filed, every office action and response, the notice of allowance.

Chain of title

⤢ drag to zoom

Titlehover for detail · click to open

See the full assignment history — every owner this patent has passed through, with recordation dates and reel/frame numbers.