Bone remodeling genes

The invention relates to 169 genes identified by their co-expression with genes known to be involved in bone remodeling and bone diseases. The invention also relates to the use of these genes and their gene products in diagnosis, prognosis, prevention, treatment, and evaluation of therapies for bone diseases such as osteoporosis.

Bone Remodeling

Bone remodeling occurs through teams of juxtaposed bone absorbing osteoclast and bone forming osteoblast and osteocyte cells. The development and proliferation of these cells from their progenitors is governed by networks of growth factors and cytokines produced in the bone microenvironment as well as by systematic hormones (Manolagas (1998) Aging 10:182-190; Teitelbaum et al. (1997) J Leukoc Biol 61:381-388). Coordinated balance between absorption and deposition is necessary to maintain bone integrity and requires intimate and complex interactions between osteoclasts and osteoblasts. Under normal states of bone homeostasis, the remodeling activities in bone serve to remove bone mass where the mechanical demands of the skeleton are low and form bone at the those sites where mechanical loads are repeatedly transmitted.

Bone is a composite material composed of an organic and an inorganic phase. By weight, approximately 70% of the tissue is mineral or inorganic matter (mainly calcium phosphate); water comprises 5 to 8%; and, the organic or extracellular matrix makes up the remainder. Approximately 95% of the mineral phase is composed of a specific crystalline hydroxyapatite that is impregnated with impurities which make up the remaining 5% of the inorganic phase. Ninety-eight percent of the organic phase is composed of type I collagen and a variety of non-collagenous proteins; cells make up the remaining 2% of this phase (Einhom (1996) The bone organ system: form and function. In: Marcus et al. eds., Osteoporosis, Academic Press, New York N.Y.). The process of matrix deposition by osteoblasts and osteocytes, subsequent mineralization and the coupling with bone resorbing activity of osteoclasts is governed by a complex interplay of systemic hormones, peptides and downstream signaling pathway proteins, local transcription factors, cytokines, growth factors and matrix remodeling genes.

Parathyroid hormone (PTH) and it's signaling system is the principal regulator of bone remodeling in the adult skeleton (Masiukiewicz and Insogna (1998) Aging 10:232-239; Mierke and Pellegrini (1999) Curr Pharm Des 5:21-36). It has a vital role in the homeostasis of calcium within the blood stream and acute in vivo effect of PTH is to increase bone resorption, although sustained increases in its circulating levels accelerate both formation and resorption. The PTH signaling pathway may also be involved in the regulation of chondrogenesis during bone formation (Vortkamp et al. (1996) Science 273:613-622; Lanske et al. (1999) J Clin Invest 104:399-407).

Several other hormones and local factors are vital to bone health. In a complex pattern of inhibition and stimulation not yet fully understood, growth hormone, insulin-like growth factor-1, the sex steroids, thyroid hormone, calciotrophic hormones such as PTH and prostaglandin E2, various cytokines, such as interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, and 1,25-dihydroxyvitamin D (calcitriol) all act coordinately in the bone remodeling process. Estrogen is involved in inhibition of osteoclast activity (Jilka et al. (1992) Science 257:88-91; Poli et al. (1994) EMBO J 13:1189-1196; Srivastava et al. (1998) J Clin Invest 102:1850-1859). Estrogen may prevent bone loss by blocking the production of cytokines in bone or bone marrow (Kimble et al. (1995) Endocrinology 136:3054-3061). Various cytokines, such as interleukin-l beta, interleukin-6, and tumor necrosis factor-alpha, influence bone remodeling (de Vemejoul (1996) Eur J Clin Chem Clin Biochem 34:729-734).

Bone Remodeling and Osteoporosis

Throughout life, old bone is removed (resorption) and new bone is added to the skeleton (formation). During childhood and teenage years, new bone is added faster than old bone is removed. As a result, bones become larger, heavier and denser. Bone formation continues at a pace faster than resorption until peak bone mass is reached during the mid-20s. After age 30, bone resorption slowly begins to exceed bone formation, most rapidly in the first few years after menopause but persistantly until death. Osteoporosis develops when bone resorption occurs too quickly or if replacement occurs too slowly. Two major classes of osteoporosis are primary and secondary osteoporosis. Type I osteoporosis occurs in a subset of postmenopausal women who are between 50 and 70 years of age and is associated with fractures of vertebral bodies and the forearm. Type II osteoporosis occurs in women and men over the age of 70 and is associated with fractures of the femoral neck and proximal humerus and tibia. In some instances, osteoporosis is a manifestation of another disease (Fauci et al. (1998) Harrison's Principles of Internal Medicine , McGraw Hill Companies, New York N.Y., pp 2249). Current therapies are designed to interfere with these growth regulatory systems to encourage the growth and function of osteoblasts and inhibit the growth and activity of osteoclasts.

The present invention satisfies a need in the art by providing new compositions that are useful for diagnosis, prognosis, treatment, prevention, and evaluation of therapies for bone remodeling and associated disorders, such as osteoporosis. We have implemented a method for analyzing gene expression patterns and have identified 169 polynucleotides by their co-expression with genes known to be involved in bone remodeling and osteoporosis.

The invention provides for a combination of substantially purified polynucleotides that are co-expressed with one or more genes known to be involved in bone remodeling and osteoporosis wherein the polynucleotides or the complements thereof are SEQ ID NOs: 1-169. The genes known to be involved in these conditions include genes encoding PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome), human parathyroid hormone, TNF receptor associated factor 2, tumor necrosis factor receptor superfamily member 11/RANK ligand, tumor necrosis factor receptor superfamily member 11A/receptor activator of NFkB (RANK), vitamin D 24-hydroxylase, natriuretic precursor protein B. human granulocyte macrophage colony stimulating factor 2, cytochrome P450, subfamily XIX, epidermal growth factor, interleukin 1 alpha, microphthalmia-associated transcription factor, bone morphogenic protein 7, human integrin-binding sialoprotein beta-3 integrin, alpha-2-Hs-glycoprotein, osteoprotegerin, interleukin 1 beta, SPI1, matrix metalloprotease 9, parathyroid receptor 1, SRC kinase insert domain receptor, vascular endothelial growth factor receptor, disintegrin and metalloprotease 12, human homolog of Drosophila mothers against decapentaplegic 6, parathyroid hormone receptor 2, glucocorticoid receptor-like 1, phosphodiesterase I, bone morphogenic protein 2, vitamin D receptor, human estrogen receptor 1, TNF receptor associated factor 5,transforming growth factor beta 1, acid phosphatase type 5, cathepsin K, bone morphogenic protein 6, secreted protein, acidic, cysteine-rich, osteonectin, vascular endothelial growth factor A, vascular endothelial growth factor receptor, bone gla protein (osteocalcin), carbonic anhydrase II, alpha-V integrin, early growth response 1, collagen type 1 alpha 2, macrophage colony stimulating factor 1, biglycan, secreted phosphoprotein (osteopontin), insulin growth factor-1, decorin, cathepsin B, colony stimulating factor receptor, and Klotho. The invention also provides a combination wherein the polynucleotides or the complements thereof are SEQ ID NOs: 107-169 that are highly co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention further provides a combination wherein the polynucleotides or the complements thereof are SEQ ID NOs: 143-169 that are very highly co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention additionally provides novel polynucleotides or complements thereof selected from SEQ ID NOs: 155-169 which are co-expressed with one or more of the genes known to be involved in bone remodeling and osteoporosis.

The invention provides a method of using a polynucleotide selected from SEQ ID NOs: 155-169 to screen a library of molecules or compounds (DNA molecules, RNA molecules, PNAs, mimetics, and proteins) to identify or purify a ligand which specifically binds the polynucleotide by combining a polynucleotide with a library of molecules or compounds under conditions to allow specific binding, and detecting specific binding, thereby identifying or purifying a ligand which specifically binds the polynuclcotide.

The invention provides for the use of at least one polynucleotide selected from SEQ ID NOs: 1-169 on an array and for the use of that array in a method for diagnosing a bone remodeling disease or disorder by hybridizing the array with a patient sample under conditions to allow complex formation, detecting complex formation, and comparing the amount of complex formation in the patient sample to that of standards for normal and diseased tissues wherein the complex formation in the patient sample indicates the presence of a bone remodeling disease or disorder.

The invention also provides for an expression vector comprising a polynucleotide selected from SEQ ID NOs: 1-169, a host cell transformed with the expression vector and a method for producing a polypeptide, the method comprising: culturing the host cell under conditions for expression of the polypeptide and recovering the polypeptide from cell culture.

The invention further provides for a polypeptide selected from SEQ ID NOs: 170-172, or a portion thereof, comprising the product of a gene that is co-expressed with one or more genes known to be involved in bone remodeling and osteoporosis. The invention additionally provides for the use of the polypeptide or a portion thereof to screen a library of molecules or compounds (DNA molecules, RNA molecules, PNAs, mimetics. proteins, agonists, antagonists, and antibodies) to identify or purify at least one ligand which specifically binds the polypeptide by combining the polypeptide or a portion thereof with the library of molecules or compounds under conditions to allow specific binding, and detecting specific binding between the polypeptide and ligand, thereby identifying or purifying a ligand which specifically binds the polypeptide.

The invention finally provides for a pharmaceutical composition comprising a polynucleotide selected from SEQ ID NOs: 1-169, polypeptide selected from SEQ ID NOs: 170-172, a ligand identified or purified using a selected polynucleotide or polypeptide which modulates the activity of the selected polynucleotide or polypeptide and a suitable pharmaceutical carrier.

A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.

The Sequence Listing provides exemplary polynucleotide sequences, SEQ ID NOs: 1-169, and polypeptide sequences, SEQ ID NOs: 170-172, which co-express with genes known to be involved in bone remodeling and osteoporosis. Each sequence is identified by a sequence identification number (SEQ ID NO) and Incyte ID No.

It must be noted that as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include the plural reference unless the context clearly dictates otherwise. Thus, for example, a reference to “a host cell” includes a plurality of such host cells, and a reference to “an antibody” is a reference to one or more antibodies and equivalents thereof known to those skilled in the art, and so forth.

“Genes known to be involved in bone remodeling or osteoporosis” have been previously identified as useful in the diagnosis, treatment, prognosis, or prevention of bone diseases and disorders and include the genes which encode PHEX, human parathyroid hormone, TNF receptor associated factor 2, tumor necrosis factor receptor superfamily member 11/RANK ligand, tumor necrosis factor receptor superfamily member 11A/receptor activator of NFkB (RANK), vitamin D 24-hydroxylase, natriuretic precursor protein B, human granulocyte macrophage colony stimulating factor 2, cytochrome P450, subfamily XIX, epidermal growth factor, interleukin 1 alpha, microphthalmia-associated transcription factor, bone morphogenic protein 7, human integrin-binding sialoprotein, beta-3 integrin, alpha-2-Hs-glycoprotein, osteoprotegerin, interleukin 1 beta, SPI 1, matrix metalloprotease 9, parathyroid receptor 1, SRC kinase insert domain receptor, vascular endothelial growth factor receptor, disintegrin and metalloprotease 12, human homolog of Drosophila mothers against decapentaplegic 6, parathyroid hormone receptor 2, glucocorticoid receptor-like 1, phosphodiesterase I, bone morphogenic protein 2, vitamin D receptor, human estrogen receptor 1, TNF receptor associated factor 5,transforming growth factor beta 1, acid phosphatase type 5, cathepsin K, bone morphogenic protein 6, secreted protein, acidic, cysteine-rich, osteonectin, vascular endothelial growth factor A, vascular endothelial growth factor receptor, bone gla protein (osteocalcin), carbonic anhydrase II, alpha-V integrin, early growth response 1, collagen type 1 alpha 2, macrophage colony stimulating factor 1, biglycan, secreted phosphoprotein (osteopontin), insulin growth factor-1, decorin, cathepsin B, colony stimulating factor receptor, and Klotho as presented in Table 3. These genes are expressed at higher levels and have more abundant transcripts in osteoporotic bone tissue than in normal or non-diseased bone or any other tissue.

“Ligand” refers to any molecule, agent, or compound which will bind specifically to a complementary site on a polynucleotide or polypeptide. Such ligands stabilize or modulate the activity of polynucleotides or polypeptides of the invention. For example, ligands may be found among libraries of inorganic and organic molecules or compounds such as nucleic acids, proteins, peptides, mimetics, carbohydrates, fats, and lipids.

“NSEQ” refers generally to a polynucleotide sequence of the present invention and includes SEQ ID NOs:1-169. “PSEQ” refers generally to a polypeptide sequence of the present invention and includes SEQ ID NOs: 170-172.

A “fragment” refers to a nucleic acid sequence that is preferably at least 20 nucleotides in length, more preferably 400 nucleotides, and most preferably 1000 nucleotides in length, and encompasses, for example, fragments consisting of 1-50, 51-400, 401-4000, 4001-12,000 nucleotides, and the like, of SEQ ID NOs: 1-169. Fragment is substantially equivalent to element and probe.

“Gene” refers to the partial or complete coding sequence of a gene including 5′ or 3′ untranslated, regulatory regions.

“Polynucleotide” refers to a nucleic acid, nucleic acid sequence, oligonucleotide, or any fragment thereof It may be DNA or RNA of genomic or synthetic origin, double-stranded or single-stranded, and combined with carbohydrate, lipids, protein or other materials to perform a particular activity or form a useful composition. “Oligonucleotide” is substantially equivalent to the terms amplimer, primer, and oligomer.

“Polypeptide” refers to an amino acid sequence, oligopeptide, peptide, or protein or portions thereof whether naturally occurring or synthetic.

A “portion” refers to peptide sequence which is preferably at least 5 to about 15 amino acids in length, most preferably at least 10 amino acids long, and which retains some biological or immunological activity of, for example, a portion of SEQ ID NOs: 170-172.

“Sample” is used in its broadest sense. A sample containing nucleic acids may comprise a bodily fluid; an extract from a cell, chromosome, organelle, or membrane isolated from a cell; genomic DNA, RNA, or cDNA in solution or bound to a substrate; a cell; a tissue; a tissue print; and the like.

“Substantially purified” refers to a nucleic acid or an amino acid sequence that is removed from its natural environment and that is isolated or separated, and is at least about 60% free, preferably about 75% free, and most preferably about 90% free, from other components with which it is naturally present.

“Substrate” refers to any rigid or semi-rigid support to which polynucleotides or polypeptides are bound and includes membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, capillaries or other tubing, plates, polymers, and microparticles with a variety of surface forms including wells, trenches, pins, channels and pores.

A “variant” refers to a polynucleotide whose sequence diverges from SEQ ID NOs: 1-169. Polynucleotide sequence divergence may result from mutational changes such as deletions, additions, and substitutions of one or more nucleotides; it may also be introduced to accommodate differences in codon usage. Each of these types of changes may occur alone, or in combination, one or more times in a given sequence.

The present invention encompasses a method for identifying polynucleotides and polypeptides that are associated with a specific disease, regulatory pathway, subcellular compartment, cell type, tissue type, or species. In particular, the method identifies polynucleotides useful in diagnosis, prognosis, treatment, prevention, and evaluation of therapies for disorders associated with bone remodeling and osteoporosis including, but not limited to, Paget's disease, osteopenia, osteoporosis, osteomalacia, rickets, including vitamin D dependent, type I and II, and x-linked hypophosphatemic rickets, Cushing's disease/syndrome, Turner syndrome, Gaucher disease, hyperparathyroidism, hypoparathyroidism, hyperthyroidism, hypogonadism, thyrotoxicosis, scurvy, calcium deficiency, systemic mastocytosis, adult hypophosphatasia, hyperadrenocorticism, osteogenesis imperfecta, homocystinuria due to cystathionine synthase deficiency, Ehlers-Danlos syndrome, Marfan's syndrome, diabetes, rheumatoid arthritis, epilepsy, primary biliary cirrhosis, chronic obstructive pulmonary disease, Menkes' syndrome, pregnancy and lactation, hepatobiliary disease, distal renal tubular acidosis, chronic renal failure, Fanconi's syndrome, and fibrogenesis imperfecta ossium.

The method entails first identifying polynucleotides that are expressed in a plurality of cDNA libraries. The identified polynucleotides include genes of known or unknown function which are expressed in a specific disease process, subcellular compartment, cell type, tissue type, or species. The expression patterns of the genes with known function are compared with those of genes with unknown function to determine whether a specified co-expression probability threshold is met. Through this comparison, a subset of the polynucleotides having a high co-expression probability with the known genes can be identified. The high co-expression probability correlates with a particular co-expression probability threshold which is preferably less than 0.001 and more preferably less than 0.00001.

The polynucleotides originate from cDNA libraries derived from a variety of sources including, but not limited to, eukaryotes such as human, mouse, rat, dog, monkey, plant, and yeast; prokaryotes such as bacteria; and viruses. These polynucleotides can also be selected from a variety of sequence types including, but not limited to, expressed sequence tags (ESTs), assembled polynucleotide sequences, full length gene coding regions, promoters, introns, enhancers, 5′ untranslated regions, and 3′ untranslated regions. To have statistically significant analytical results, the polynucleotides need to be expressed in at least three cDNA libraries.

The cDNA libraries used in the co-expression analysis of the present invention can be obtained from adrenal gland, biliary tract, bladder, blood cells, blood vessels, bone marrow, brain, bronchus, cartilage, chromaffin system, colon, connective tissue, cultured cells, embryonic stem cells, endocrine glands, epithelium, esophagus, fetus, ganglia, heart, hypothalamus, immune system, intestine, islets of Langerhans, kidney, larynx, liver, lung, lymph, muscles, neurons, ovary, pancreas, penis, peripheral nervous system, phagocytes, pituitary, placenta, pleurus, prostate, salivary glands, seminal vesicles, skeleton, spleen, stomach, testis, thymus, tongue, ureter, uterus, and the like. The number of cDNA libraries selected can range from as few as 3 to greater than 10,000. Preferably, the number of cDNA libraries is greater than 500.

In a preferred embodiment, genes are assembled from related sequences, such as assembled sequence fragments derived from a single transcript. Assembly of the sequences can be performed using sequences of various types including, but not limited to, ESTs, extensions, or shotgun sequences. In a most preferred embodiment, the polynucleotide sequences are derived from human sequences that have been assembled using the algorithm disclosed in “System and Methods for Analyzing Biomolecular Sequences”, Lincoln et al. U.S. Pat. No. 9,276,534, filed Mar. 25, 1999, incorporated herein by reference.

Experimentally, differential expression of the polynucleotides can be evaluated by methods including, but not limited to, differential display by spatial immobilization or by gel electrophoresis, genome mismatch scanning, representational difference analysis, and transcript imaging. Additionally, differential expression can be assessed by microarray technology. These methods may be used alone or in combination.

Genes known to be involved in bone remodeling and osteoporosis are selected based on the published use of the genes or gene products as diagnostic or prognostic markers or as therapeutic targets.

The procedure for identifying novel genes that exhibit a statistically significant co-expression pattern with genes known to be associated with bone remodeling and osteoporosis is as follows. First, the presence or absence of a gene in a cDNA library is defined: a gene is present in a cDNA library when at least one cDNA fragment corresponding to that gene is detected in a cDNA sample taken from the library, and a gene is absent from a library when no corresponding cDNA fragment is detected in the sample.

Second, the significance of gene co-expression is evaluated using a probability method to measure a due-to-chance probability of the co-expression. The probability method can be the Fisher exact test, the chi-squared test, or the kappa test. These tests and examples of their applications are well known in the art and can be found in standard statistics texts (Agresti (1990) Categorical Data Analysis , John Wiley & Sons, New York N.Y., Rice (1988) Mathematical Statistics and Data Analysis , Duxbury Press, Pacific Grove Calif.). A Bonferroni correction (Rice, supra, p. 384) can also be applied in combination with one of the probability methods for correcting statistical results of one gene versus multiple other genes. In a preferred embodiment, the due-to-chance probability is measured by a Fisher exact test, and the threshold of the due-to-chance probability is set preferably to less than 0.001, more preferably to less than 0.00001.

To determine whether two genes, A and B. have similar co-expression patterns, occurrence data vectors can be generated as illustrated in Table 1. The presence of a gene occurring at least once in a library is indicated by a one, and its absence from the library, by a zero.

For a given pair of genes, the occurrence data in Table 1 can be summarized in a 2×2 contingency table.

Table 2 presents co-occurrence data for gene A and gene B in a total of 30 libraries. Both gene A and gene B occur 10 times in the libraries. Table 2 summarizes and presents: 1) the number of times gene A and B are both present in a library; 2) the number of times gene A and B are both absent in a library; 3) the number of times gene A is present, and gene B is absent; and 4) the number of times gene B is present, and gene A is absent. The upper left entry is the number of times the two genes co-occur in a library, and the middle right entry is the number of times neither gene occurs in a library. The off diagonal entries are the number of times one gene occurs, and the other does not. Both A and B are present eight times and absent 18 times. Gene A is present, and gene B is absent, two times; and gene B is present, and gene A is absent, two times. The probability (p-value) that the above association occurs due to chance as calculated using a Fisher exact test is 0.0003. Associations are generally considered significant if a p-value is less than 0.01 (Agresti, supra; Rice, supra).

This method of estimating the probability for co-expression of two genes makes several assumptions. The method assumes that the libraries are independent and are identically sampled. However, in practical situations, the selected cDNA libraries are not entirely independent, because more than one library may be obtained from a single subject or tissue. Nor are they entirely identically sampled, because different numbers of cDNAs may be sequenced from each library. The number of cDNAs sequenced typically ranges from 5,000 to 10,000 cDNAs per library. In addition, because a Fisher exact co-expression probability is calculated for each gene versus 45,233 other assembled genes, a Bonferroni correction for multiple statistical tests is used.

The present invention identifies 169 novel polynucleotides that exhibit strong association with genes known to be involved in bone remodeling or osteoporosis. The results presented in “Tables 4 and 5” show that the expression of the 169 novel polynucleotides has direct or indirect association with the expression of genes known to be involved in bone remodeling. Therefore, the novel polynucleotides can potentially be used in diagnosis, treatment, prognosis, or prevention of bone diseases or disorders or in the evaluation of therapies for such diseases and disorders. Further, the gene products of the 169 novel polynucleotides are either potential therapeutics or targets of therapeutics against bone diseases and disorders.

Therefore, in one embodiment, the present invention encompasses a polynucleotide sequence comprising the sequence of SEQ ID NOs: 1-169. These 169 polynucleotides are shown by the method of the present invention to have strong co-expression association with genes known to be involved in bone remodeling and osteoporosis and with each other. The invention also encompasses a variant of the polynucleotide sequence, its complement, or 15 consecutive nucleotides of a sequence provided in the above described sequences. Variant polynucleotide sequences typically have at least about 75%, more preferably at least about 85%, and most preferably at least about 95% polynucleotide sequence identity to NSEQ.

NSEQ or the encoded PSEQ may be used to search against the GenBank primate (pri), rodent (rod), mammalian (mam), vertebrate (vrtp), and eukaryote (eukp) databases, SwissProt, BLOCKS (Bairoch et al. (1997) Nucleic Acids Res. 25:217-221), PFAM, and other databases that contain previously identified and annotated motifs, sequences, and gene functions. Methods that search for primary sequence patterns with secondary structure gap penalties (Smith et al. (1992) Protein Engineering 5:35-51) as well as algorithms such as Basic Local Alignment Search Tool (BLAST; Altschul (1993) J Mol Evol 36:290-300; Altschul et al. (1990) J Mol Biol 215:403-410), BLOCKS (Henikoff and Henikoff (1991) Nucleic Acids Res 19:6565-6572), Hidden Markov Models (HMM; Eddy (1996) Cur Opin Str Biol 6:361-365; Sonnhammer et al. (1997) Proteins 28:405-420), and the like, can be used to manipulate and analyze nucleotide and amino acid sequences. These databases, algorithms and other methods are well known in the art and are described in Ausubel et al. (1997 ; Short Protocols in Molecular Biology , John Wiley & Sons, New York N.Y., unit 7.7) and in Meyers (1995 ; Molecular Biology and Biotechnology , Wiley VCH, New York N.Y., p 856-853).

Also encompassed by the invention are polynucleotide sequences that are capable of hybridizing to SEQ ID NOs: 1-169, and fragments thereof under stringent conditions. Stringent conditions can be defined by salt concentration, temperature, and other chemicals and conditions well known in the art. Conditions can be selected, for example, by varying the concentrations of salt in the prehybridization, hybridization, and wash solutions or by varying the hybridization and wash temperatures. With some substrates, the temperature can be decreased by adding formamide to the prehybridization and hybridization solutions.

Hybridization can be performed at low stringency. with buffers such as 5×SSC with 1% sodium dodecyl sulfate (SDS) at 60° C., which permits complex formation between two nucleic acid sequences that contain some mismatches. Subsequent washes are performed at higher stringency with buffers such as 0.2×SSC with 0.1% SDS at either 45° C. (medium stringency) or 68° C. (high stringency), to maintain hybridization of only those complexes that contain completely complementary sequences. Background signals can be reduced by the use of detergents such as SDS, Sarcosyl, or Triton X-100, and/or a blocking agent, such as salmon sperm DNA. Hybridization methods are described in detail in Ausubel (supra, units 2.8-2.11, 3.18-3.19 and 4-6-4.9) and Sambrook et al. (1989 ; Molecular Cloning. A Laboratory Manual , Cold Spring Harbor Press, Plainview N.Y.)

NSEQ can be extended utilizing a partial nucleotide sequence and employing various PCR-based methods known in the art to detect upstream sequences such as promoters and other regulatory elements. (Sec, e.g., Dieffenbach and Dveksler (1995) PCR Primer, a Laboratory Manual , Cold Spring Harbor Press, Plainview N.Y.). Additionally, one may use an XL-PCR kit (PE Biosystems, Foster City Calif.), nested primers, and commercially available cDNA libraries (Life Technologies, Rockville Md.) or genomic libraries (Clontech, Palo Alto Calif.) to extend the sequence. For all PCR-based methods, primers may be designed using commercially available software, such as OLIGO 4.06 Primer Analysis software (National Biosciences, Plymouth Minn.) or another program, to be about 15 to 30 nucleotides in length, to have a GC content of about 50%, and to form a hybridization complex at temperatures of about 68° C. to 72° C.

In another aspect of the invention, NSEQ can be cloned in recombinant DNA molecules that direct the expression of PSEQ, or structural or functional portions thereof, in host cells. Due to the inherent degeneracy of the genetic code, other DNA sequences which encode substantially the same or a functionally equivalent amino acid sequence may be produced and used to express the polypeptide encoded by NSEQ. The nucleotide sequences of the present invention can be engineered using methods generally known in the art in order to alter the nucleotide sequences for a variety of purposes including, but not limited to, modification of the cloning, processing, and/or expression of the gene product. DNA shuffling by random fragmentation and PCR reassembly of gene fragments and synthetic oligonucleotides may be used to engineer the nucleotide sequences. For example, oligonucleotide-mediated site-directed mutagenesis may be used to introduce mutations that create new restriction sites, alter glycosylation patterns, change codon preference, produce splice variants, and so forth.

In order to express a biologically active polypeptide, NSEQ, or derivatives thereof, may be inserted into an expression vector, i.e., a vector which contains the elements for transcriptional and translational control of the inserted coding sequence in a particular host. These elements include regulatory sequences, such as enhancers, constitutive and inducible promoters, and 5′ and 3′ untranslated regions. Methods which are well known to those skilled in the art may be used to construct such expression vectors. These methods include in vitro recombinant DNA techniques, synthetic techniques, and in vivo genetic recombination. (See, e.g., Sambrook, supra; and Ausubel, supra).

A variety of expression vector/host cell systems may be utilized to express NSEQ. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors; yeast transformed with yeast expression vectors; insect cell systems infected with baculovirus vectors; plant cell systems transformed with viral or bacterial expression vectors; or animal cell systems. For long term production of recombinant proteins in mammalian systems, stable expression in cell lines is preferred. For example, NSEQ can be transformed into cell lines using expression vectors which may contain viral origins of replication and/or endogenous expression elements and a selectable or visible marker gene on the same or on a separate vector. The invention is not to be limited by the vector or host cell employed.

In general, host cells that contain NSEQ and that express PSEQ may be identified by a variety of procedures known to those of skill in the art. These procedures include, but are not limited to, DNA—DNA or DNA-RNA hybridizations, PCR amplification, and protein bioassay or immunoassay techniques which include membrane, solution, or chip based technologies for the detection and/or quantification of nucleic acid or amino acid sequences. Immunological methods for detecting and measuring the expression of PSEQ using either specific polyclonal or monoclonal antibodies arc known in the art. Examples of such techniques include enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and fluorescence activated cell sorting (FACS).

Host cells transformed with NSEQ may be cultured under conditions for the expression and recovery of the polypeptide from cell culture. The polypeptide produced by a transgenic cell may be secreted or retained intracellularly depending on the sequence and/or the vector used. As will be understood by those of skill in the art, expression vectors containing NSEQ may be designed to contain signal sequences which direct secretion of the polypeptide through a prokaryotic or eukaryotic cell membrane.

In addition, a host cell strain may be chosen for its ability to modulate expression of the inserted sequences or to process the expressed polypeptide in the desired fashion. Such modifications of the polypeptide include, but are not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation, and acylation. Post-translational processing which cleaves a “prepro” form of the polypeptide may also be used to specify, protein targeting, folding, and/or activity. Different host cells which have specific cellular machinery and characteristic mechanisms for post-translational activities (e.g., CHO, HeLa, MDCK, HEK293, and W138) are available from the American Type Culture Collection (ATCC, Manassas Md.) and may be chosen to ensure the correct modification and processing of the expressed polypeptide.

In another embodiment of the invention, natural, modified, or recombinant nucleic acid sequences are ligated to a heterologous sequence resulting in translation of a fusion polypeptide containing heterologous polypeptide moieties in any of the aforementioned host systems. Such heterologous polypeptide moieties facilitate purification of fusion polypeptides using commercially available affinity matrices. Such moieties include, but are not limited to, glutathione S-transferase, maltose binding protein, thioredoxin, calmodulin binding peptide, 6-His, FLAG, c-myc, hemaglutinin, and monoclonal antibody epitopes.

In another embodiment, the nucleic acid sequences are synthesized, in whole or in part, using chemical or enzymatic methods well known in the art (Caruthers et al. (1980) Nucl Acids Symp Ser 215-233; Ausubel, supra). For example, peptide synthesis can be performed using various solid-phase techniques (Roberge et al. (1995) Science 269:202-204), and machines such as the ABI 431A Peptide synthesizer (PE Biosystems) can be used to automate synthesis. If desired, the amino acid sequence may be altered during synthesis and/or combined with sequences from other proteins to produce a variant protein.

In another embodiment, the invention entails a substantially purified polypeptide comprising the amino acid sequence of SEQ ID NOs: 170-172 and fragments thereof.

The polynucleotide sequences can be used in diagnosis, prognosis, treatment, prevention, and selection and evaluation of therapies for diseases and disorders involved in bone remodeling or osteoporosis including, but not limited to, Paget's disease, osteopenia, osteoporosis, osteomalacia, rickets, including vitamin D dependent, type I and II, and x-linked hypophosphatemic rickets, Cushing's disease/syndrome, Tumer syndrome, Gaucher disease, hyperparathyroidism, hypoparathyroidism, hyperthyroidism, hypogonadism, thyrotoxicosis, scurvy, calcium deficiency, systemic mastocytosis, adult hypophosphatasia, hyperadrenocorticism, osteogenesis imperfecta, homocystinuria due to cystathionine synthase deficiency, Ehlers-Danlos syndrome, Marfan's syndrome, diabetes, rheumatoid arthritis, epilepsy, primary biliary cirrhosis, chronic obstructive pulmonary disease, Menkes' syndrome, pregnancy and lactation, hepatobiliary disease, distal renal tubular acidosis, chronic renal failure, Fanconi's syndrome. and fibrogenesis imperfecta ossium.

The polynucleotide sequences may be used to screen a library of molecules for specific binding affinity. The assay can be used to screen a library of DNA molecules, RNA molecules, PNAs, peptides, ribozymes, antibodies, agonists, antagonists, immunoglobulins, inhibitors, proteins including transcription factors, enhancers, repressors, and drugs and the like which regulate the activity of the polynucleotide sequence in the biological system. The assay involves providing a library of molecules, combining the polynucleotide sequence or a fragment thereof with the library of molecules under conditions suitable to allow specific binding, and detecting specific binding to identify, at least one molecule which specifically binds the polynucleotide sequence.

Similarly the polypeptides or portions thereof may be used to screen libraries of molecules or compounds in any of a variety of screening assays. The portion of a polypeptide employed in such screening may be free in solution, affixed to an abiotic or biotic substrate (e.g. bome on a cell surface), or located intracellularly. Specific binding between the polypeptide and the molecule may be measured. The assay can be used to screen a library of DNA molecules, RNA molecules, PNAs, peptides, mimetics, ribozymes, antibodies, agonists, antagonists, immunoglobulins, inhibitors, peptides, polypeptides, drugs and the like, which specifically bind the polypeptide. One method for high throughput screening using very small assay volumes and very small amounts of test compound is described in Burbaum et al. U.S. Pat. No. 5,876,946, incorporated herein by reference, which screens large numbers of molecules for enzyme inhibition or receptor binding.

In one preferred embodiment, the polynucleotide sequences are used for diagnostic purposes to determine the absence, presence, or altered-increased or decreased compared to a normal standard-expression of the gene. The polynucleotides may be at least 15 nucleotides long and consist of complementary RNA and DNA molecules, branched nucleic acids, and/or peptide nucleic acids (PNAs). In one alternative, the polynucleotides are used to detect and quantify gene expression in samples in which expression of NSEQ is correlated with disease. In another alternative, NSEQ can be used to detect genetic polymorphisms associated with a disease. These polymorphisms may be detected in the transcript cDNA.

The specificity of the probe is determined by whether it is made from a unique region, a regulatory region, or from a conserved motif. Both probe specificity and the stringency of diagnostic hybridization or amplification (maximal, high, intermediate, or low) will determine whether the probe identifies only naturally occurring, exactly complementary sequences, allelic variants, or related sequences. Probes designed to detect related sequences should preferably have at least 50% sequence identity to any of the polynucleotides encoding PSEQ.

Methods for producing hybridization probes include the cloning of nucleic acid sequences into vectors for the production of mRNA probes. Such vectors are known in the art, are commercially available, and may be used to synthesize RNA probes in vitro by adding RNA polymerases and labeled nucleotides. Hybridization probes may incorporate nucleotides labeled by a variety of reporter groups including, but not limited to, radionuclides such as 32 p or 35 S, enzymatic labels such as alkaline phosphatase coupled to the probe via avidin/biotin coupling systems, fluorescent labels, and the like. The labeled polynucleotide sequences may be used in Southern or northern analysis, dot blot, or other membrane-based technologies; in PCR technologies; and in microarrays utilizing samples from subjects to detect altered PSEQ expression.

NSEQ can be labeled by standard methods and added to a sample from a subject under conditions for the formation and detection of hybridization complexes. After incubation the sample is washed, and the signal associated with hybrid complex formation is quantitated and compared with a standard value. Standard values are derived from any control sample, typically one that is free of the suspect disease. If the amount of signal in the subject sample is altered in comparison to the standard value, then the presence of altered levels of expression in the sample indicates the presence of the disease. Qualitative and quantitative methods for comparing the hybridization complexes formed in subject samples with previously established standards are well known in the art.

Such assays may also be used to evaluate the efficacy of a particular therapeutic treatment regimen in animal studies, in clinical trials, or to monitor the treatment of an individual subject. Once the presence of disease is established and a treatment protocol is initiated, hybridization or amplification assays can be repeated on a regular basis to determine if the level of expression in the patient begins to approximate that which is observed in a healthy subject. The results obtained from successive assays may be used to show the efficacy of treatment over a period ranging from several days to many years.

The polynucleotides may be used for the diagnosis of a variety of diseases or disorders associated with bone remodeling or osteoporosis. These include, but are not limited to, Paget's disease, osteopenia, osteoporosis, osteomalacia, rickets, including vitamin D dependent, type I and II, and x-linked hypophosphatemic rickets, Cushing's disease/syndrome, Tumer syndrome, Gaucher disease, hyperparathyroidism, hypoparathyroidism, hyperthyroidism, hypogonadism, thyrotoxicosis, scurvy, calcium deficiency, systemic mastocytosis, adult hypophosphatasia, hyperadrenocorticism, osteogenesis imperfecta, homocystinuria due to cystathionine synthase deficiency, Ehlers-Danlos syndrome, Marfan's syndrome, diabetes, rheumatoid arthritis, epilepsy, primary biliary cirrhosis, chronic obstructive pulmonary disease, Menkes' syndrome, pregnancy and lactation, hepatobiliary disease, distal renal tubular acidosis, chronic renal failure, Fanconi's syndrome, and fibrogenesis imperfecta ossium.

The polynucleotides may also be used as targets in a microarray. The microarray can be used to monitor the expression patteins of large numbers of genes simultaneously and to identify splice variants, mutations, and polymorphisms. Information derived from analyses of the expression patterns may be used to determine gene function, to understand the genetic basis of a disease, to diagnose a disease, and to develop and monitor the activities of therapeutic agents used to treat a disease. Microarrays may also be used to detect genetic diversity, single nucleotide polymorphisms which may characterize a particular population, at the genome level.

In yet another alternative, polynucleotides may be used to generate hybridization probes useful in mapping the naturally occurring genomic sequence. Fluorescent in situ hybridization (FISH) may be correlated with other physical chromosome mapping techniques and genetic map data as described in Heinz-Ulrich et al. (In: Meyers, supra, pp. 965-968).

In another embodiment, antibodies or Fabs comprising an antigen binding site that specifically binds PSEQ may be used for the diagnosis of diseases characterized by the over-or-under expression of PSEQ. A variety of protocols for measuring PSEQ, including ELISAs, RIAs, and FACS, are well known in the art and provide a basis for diagnosing altered or abnormal levels of expression. Standard values for PSEQ expression are established by combining samples taken from healthy subjects, preferably human, with antibody to PSEQ under conditions for complex formation The amount of complex formation may be quantitated by various methods, preferably by photometric means. Quantities of PSEQ expressed in disease samples are compared with standard values. Deviation between standard and subject values establishes the parameters for diagnosing or monitoring disease. Alternatively, one may use competitive drug screening assays in which neutralizing antibodies capable of binding PSEQ specifically compete with a test compound for binding the polypeptide. Antibodies can be used to detect the presence of any peptide which shares one or more antigenic determinants with PSEQ. In one aspect, the anti-PSEQ antibodies of the present invention can be used for treatment or monitoring therapeutic treatment for bone remodeling disorders or osteoporosis.

In another aspect, the NSEQ, or its complement, may be used therapeutically for the purpose of expressing mRNA and polypeptide, or conversely to block transcription or translation of the mRNA. Expression vectors may be constructed using elements from retroviruses, adenoviruses, herpes or vaccinia viruses, or bacterial plasmids, and the like. These vectors may be used for delivery of nucleotide sequences to a particular target organ, tissue, or cell population. Methods well known to those skilled in the art can be used to construct vectors to express nucleic acid sequences or their complements. (See, e.g., Maulik et al. (1997) Molecular Biotechnology, Therapeutic Applications and Strategies , Wiley-Liss, New York N.Y.) Alternatively, NSEQ, or its complement, may be used for somatic cell or stem cell gene therapy. Vectors may be introduced in vivo, in vitro, and ex vivo. For ex vivo therapy, vectors are introduced into stem cells taken from the subject, and the resulting transgenic cells are clonally propagated for autologous transplant back into that same subject. Delivery of NSEQ by transfection, liposome injections, or polycationic amino polymers may be achieved using methods which are well known in the art. (See, e.g., Goldman et al. (1997) Nature Biotechnology 15:462-466.) Additionally, endogenous NSEQ expression may be inactivated using homologous recombination methods which insert an inactive gene sequence into the coding region or other targeted region of NSEQ. (See, e.g. Thomas et al. (1987) Cell 51: 503-512.)

Vectors containing NSEQ can be transformed into a cell or tissue to express a missing polypeptide or to replace a nonfunctional polypeptide. Similarly a vector constructed to express the complement of NSEQ can be transformed into a cell to downregulate the overexpression of PSEQ. Complementary or antisense sequences may consist of an oligonucleotide derived from the transcription initiation site; nucleotides between about positions −10 and +10 from the ATG are preferred. Similarly, inhibition can be achieved using triple helix base-pairing methodology. Triple helix pairing is useful because it causes inhibition of the ability of the double helix to open sufficiently for the binding of polymerases, transcription factors, or regulatory molecules. Recent therapeutic advances using triplex DNA have been described in the literature. (See, e.g., Gee et al. In: Huber and Carr (1994) Molecular and Immunologic Approaches , Futura Publishing Co., Mt. Kisco N.Y., pp. 163-177.)

Ribozymes, enzymatic RNA molecules, may also be used to catalyze the cleavage of mRNA and decrease the levels of particular mRNAs, such as those comprising the polynucleotide sequences of the invention. (See, e.g., Rossi (1994) Current Biology 4: 469-471.) Ribozymes may cleave mRNA at specific cleavage sites. Alternatively, ribozymes may cleave mRNAs at locations dictated by flanking regions that form complementary base pairs with the target mRNA. The construction and production of ribozymes is well known in the art and is described in Meyers (supra).

RNA molecules may be modified to increase intracellular stability and half-life. Possible modifications include, but are not limited to, the addition of flanking sequences at the 5′ and/or 3′ ends of the molecule, or the use of phosphorothioate or 2′ O-methyl rather than phosphodiester linkages within the backbone of the molecule. Alternatively, nontraditional bases such as inosine, queosine, and wybutosine, as well as acetyl-, methyl-, thio-, and similarly modified forms of adenine, cytidine, guanine, thymine, and uridine which are not as easily recognized by endogenous endonucleases, may be included.

Further, an antagonist, or an antibody that binds specifically to PSEQ may be administered to a subject to treat or prevent diseases or disorders associated with bone remodeling or osteoporosis. The antagonist, antibody, or fragment may be used directly to inhibit the activity of the polypeptide or indirectly to deliver a therapeutic agent to cells or tissues which express the PSEQ. An immunoconjugate comprising a PSEQ binding site of the antibody or the antagonist and a therapeutic agent may be administered to a subject in need to treat or prevent disease. The therapeutic agent may be a cytotoxic agent selected from a group including, but not limited to, abrin, ricin, doxorubicin, daunorubicin, taxol, ethidium bromide, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicine, dihydroxy anthracin dione, actinomycin D, diphteria toxin, Pseudomonas exotoxin A and 40, radioisotopes, and glucocorticoid.

Antibodies to PSEQ may be generated using methods that are well known in the art. Such antibodies may include, but are not limited to, polyclonal, monoclonal, chimeric, and single chain antibodies, Fab fragments, and fragments produced by a Fab expression library. Neutralizing antibodies, such as those which inhibit dimer formation, are especially preferred for therapeutic use. Monoclonal antibodies to PSEQ may be prepared using any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to, the hybridoma, the human B-cell hybridoma, and the EBV-hybridoma techniques. In addition, techniques developed for the production of chimeric antibodies can be used. (See, e.g., Pound (1998) Immunochemical Protocols , Methods Mol Biol Vol. 80). Alternatively, techniques described for the production of single chain antibodies may be employed. Fabs which contain specific binding sites for PSEQ may also be generated. Various immunoassays may be used to identify antibodies having the desired specificity. Numerous protocols for competitive binding or immunoradiometric assays using either polyclonal or monoclonal antibodies with established specificities are well known in the art.

Yet further, an agonist of PSEQ may be administered to a subject to treat or prevent a disease associated with decreased expression, longevity or activity of PSEQ.

An additional aspect of the invention relates to the administration of a pharmaceutical or sterile composition, in conjunction with a pharmaceutically acceptable carrier, for any of the therapeutic applications discussed above. Such pharmaceutical compositions may consist of PSEQ or antibodies, mimetics, agonists, antagonists, or inhibitors of the polypeptide. The compositions may be administered alone or in combination with at least one other agent, such as a stabilizing compound, which may be administered in any sterile, biocompatible pharmaceutical carrier including, but not limited to, saline, buffered saline, dextrose, and water. The compositions may be administered to a subject alone or in combination with other agents, drugs, or hormones.

The pharmaceutical compositions utilized in this invention may be administered by any number of routes including, but not limited to, oral, intravenous, intramuscular, intra-arterial, intramedullary, intrathecal, intraventricular, transdermal, subcutaneous, intraperitoneal, intranasal, enteral, topical, sublingual, or rectal means.

In addition to the active ingredients, these pharmaceutical compositions may contain pharmaceutically-acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. Further details on techniques for formulation and administration may be found in the latest edition of Remington's Pharmaceutical Sciences (Maack Publishing Co., Easton Pa.).

For any compound, the therapeutically effective dose can be estimated initially either in cell culture assays or in animal models such as mice, rats, rabbits, dogs, or pigs. An animal model may also be used to determine the concentration range and route of administration. Such information can then be used to determine useful doses and routes for administration in humans.

A therapeutically effective dose refers to that amount of active ingredient which ameliorates the symptoms or condition. Therapeutic efficacy and toxicity may be determined by standard pharmaceutical procedures in cell cultures or with experimental animals, such as by calculating and contrasting the ED 50 (the dose therapeutically effective in 50% of the population) and LD 50 (the dose lethal to 50% of the population) statistics. Any of the therapeutic compositions described above may be applied to any subject in need of such therapy, including, but not limited to, mammals such as dogs, cats, cows, horses, rabbits, monkeys, and most preferably, humans.

It is to be understood that this invention is not limited to the particular devices, machines, materials and methods described. Although particular embodiments are described, equivalent embodiments may be used to practice the invention. The described embodiments are provided to illustrate the invention and are not intended to limit the scope of the invention which is limited only by the appended claims.

I cDNA Library Construction

The cDNA library, BONTNOT01, was selected as an example to demonstrate the construction of cDNA libraries from which the novel polynucleotides were derived. The BONTNOT01 tibial periosteum library was constructed using 7 nanograms of polyA RNA isolated from tibial periosteum removed from a 20-year-old Caucasian male. Pathology for the matched tumor tissue indicated partially necrotic and cystic ostcoblastic grade 3 osteosarcoma (post-chemotherapy). The tumor involved almost the entire length of the femoral shaft along the site of a previously placed metal rod tract.

The frozen tibial periosteum was homogenized and lysed in a guanidinium isothiocyanate solution using a POLYTRON homogenizer (PT-3000, Brinkmann Instruments, Westbury N.J.). The lysate was centrifuged over a 5.7 M CsCl cushion using an SW28 rotor in an L8-70M ultracentrifuge (Beckman Coulter, Fullerton Calif.) for 18 hours at 25,000 rpm at ambient temperature. The RNA was extracted with acid phenol, pH 4.7, precipitated using 0.3 M sodium acetate and 2.5 volumes of ethanol, resuspended in RNAse-free water, and treated with DNase at 37° C. RNA extraction and precipitation was repeated as before. The mRNA was isolated with the OLIGOTEX kit (Qiagen, Chatsworth Calif.) and used to construct the cDNA library.

The mRNA was handled according to the recommended protocols in the SUPERSCRIPT plasmid system (Life Technologies). The cDNAs were fractionated on a SEPHAROSE CL-4B column (Amersham Pharmacia Biotech, Piscataway N.J.), and those cDNAs exceeding 400 bp were ligated into PSPORT I (Life Technologies). The plasmid was subsequently transformed into DH5α competent cells (Life Technologies).

II Isolation and Sequencing of cDNA Clones

Plasmid DNA was released from the cells and purified using the REAL PREP 96 plasmid kit (Qiagen). This kit enabled the simultaneous purification of 96 samples in a 96-well block using multi-channel reagent dispensers. The recommended protocol was employed except for the following changes: 1) the bacteria were cultured in 1 ml of sterile Terrific Broth (Life Technologies) with carbenicillin at 25 mg/l and glycerol at 0.4%; 2) after inoculation, the cells were cultured for 19 hours and lysed with 0.3 ml of Iysis buffer; and 3) following isopropanol precipitation, the DNA pellet was resuspended in 0.1 ml of distilled water. After the last step in the protocol, samples were transferred to a 96-well block for storage at 4° C.

The cDNAs were prepared using a MICROLAB 2200 system (Hamilton, Reno Nev.) in combination with DNA ENGINE thermal cyclers (PTC200; MJ Research, Waltham Mass.). The cDNAs were sequenced by the method of Sanger and Coulson (1975; J. Mol. Biol. 94:441f) using ABI PRISM 377 DNA sequencing systems (PE Biosystems). Most of the sequences were sequenced using standard ABI protocols and kits (PE Biosystems) at solution volumes of 0.25×-1.0×. In the alternative, some of the sequences were sequenced using solutions and dyes from Amersham Pharmacia Biotech.

III Selection, Assembly, and Characterization of Sequences

The sequences used for co-expression analysis were assembled from EST sequences, 5′ and 3′long read sequences, and full length coding sequences. Selected assembled sequences were expressed in at least three cDNA libraries.

The assembly process is described as follows. EST sequence chromatograms were processed and verified. Quality scores were obtained using PHRED (Ewing et al. (1998) Genome Res 8:175-185; Ewing and Green (1998) Genome Res 8:186-194), and edited sequences were loaded into a relational database management system (RDBMS). The sequences were clustered using BLAST with a product score of 50. All clusters of two or more sequences created a bin which represents one transcribed gene.

Assembly of the component sequences within each bin was performed using a modification of Phrap, a publicly available program for assembling DNA fragments (Green, P. University of Washington, Seattle Wash.). Bins that showed 82% identity from a local pair-wise alignment between any of the consensus sequences were merged.

Bins were annotated by screening the consensus sequence in each bin against public databases, such as GBpri and GenPept from NCBI. The annotation process involved a FASTn screen against the GBpri database in GenBank. Those hits with a percent identity of greater than or equal to 75% and an alignment length of greater than or equal to 100 base pairs were recorded as homolog hits. The residual unannotated sequences were screened by FASTx against GenPept. Those hits with an E value of less than or equal to 10 −8 were recorded as homolog hits.

Sequences were then reclustered using BLASTn and Cross-Match, a program for rapid amino acid and nucleic acid sequence comparison and database search (Green. supra), sequentially. Any BLAST alignment between a sequence and a consensus sequence with a score greater than 150 was realigned using cross-match. The sequence was added to the bin whose consensus sequence gave the highest Smith-Waterman score (Smith et al. (1992) Protein Engineering 5:35-51) amongst local alignments with at least 82% identity. Non-matching sequences were moved into new bins. and assembly processes were repeated.

IV Co-expression Analyses of Bone Remodeling and Osteoporosis-Associated Genes

Fifty-five genes known to be involved in bone remodeling and osteoporosis were selected to identify the novel polynucleotides of the Sequence Listing. The known genes and brief descriptions of their functions are listed in Table 3.

V Novel Genes Co-Expressed with Genes Involved with Bone Remodeling and Osteoporosis

Using the co-expression analysis method, 169 polynucleotides, including 18 novel polynucleotides, have been identified.

Polynucleotides comprising the consensus sequences of SEQ ID NOs: 1-169 of the present invention were first identified from Incyte bins and assembled as described in Example III. BLAST and other motif searches were performed for SEQ ID NOs: 1-169 according to Example VI. The full length and 5′-complete sequences were translated, and sequence identity was investigated using the methods described in Example VI.

SEQ ID NO: 170 of the present invention was encoded by the polynucleotide of SEQ ID NO: 159. SEQ ID NO: 170 has 93 amino acids. Motif analyses of SEQ ID NO: 170 shows one potential casein kinase II phosphorylation site at residue T85. BLOCKS identifies a potential single-strand binding protein domain from S2 to V11.

SEQ ID NO: 171 of the present invention was encoded by the polynucleotide of SEQ ID NO:37. SEQ ID NO: 177 has 353 amino acids. Motif analyses of SEQ ID NO: 171 shows two potential cAMP- and cGMP-dependent protein kinase phosphorylation sites at residues T198 and S240, respectively; six potential casein kinase II phosphorylation sites at residues T189, S240, S266, S285, and T326, respectively; seven potential protein kinase C phosphorylation sites at residues T60, T77, S110, S194, S210, S256, and T278, respectively. Additionally, SEQ ID NO:171 contains a potential zinc finger C3HC4 type signature sequence from residue C39 to C47. BLOCKS identifies a potential zinc finger C3HC4 type domain at C39 to C47, and Pfam identifies a potential zinc finger C3HC4 type domain at C23 to C47.

SEQ ID NO: 172 of the present invention was encoded by the polynucleotide of SEQ ID NO:85. SEQ ID NO: 178 has 574 amino acids. Motif analyses of SEQ ID NO: 172 shows three potential N-glycosylation sites at residues N76, N240, and N488, respectively; one potential cAMP- and cGMP-dependent protein kinase phosphorylation site at residue T370; seven potential casein kinase II phosphorylation sites at residues S27, T188, S324, S342, T500, T547, and S563, respectively; and nine potential protein kinase C phosphorylation sites at residues T168, S261, S299, S324, T364, S365, S403, S440, and S529, respectively.

VI Homology Searching of the Co-Expressed Polynucleotides and Polypeptides

The polynucleotide sequences, SEQ ID NOs: 1-169, and polypeptide sequences, SEQ ID NOs: 170-172, were queried against databases derived from sources such as GenBank and SwissProt. These databases, which contain previously identified and annotated sequences, were searched for regions of similarity using BLAST (Altschul, supra). BLAST searched for matches and reported only those that satisfied the probability thresholds of 10 −25 or less for nucleotide sequences and 10 −8 or less for polypeptide sequences.

The polypeptide sequence was also analyzed for known motif patterns using MOTIFS, SPSCAN, BLIMPS, and HMM-based protocols. MOTIFS (Genetics Computer Group, Madison Wis.) searches polypeptide sequences for patterns that match those defined in the Prosite Dictionary of Protein Sites and Patterns (Bairoch, supra) and displays the patterns found and their corresponding literature abstracts. SPSCAN (Genetics Computer Group) searches for potential signal peptide sequences using a weighted matrix method (Nielsen et al. (1997) Prot. Eng. 10:1-6). Hits with a score of 5 or greater were considered. BLIMPS uses a weighted matrix analysis algorithm to search for sequence similarity between the polypeptide sequences and those contained in BLOCKS, a database consisting of short amino acid segments, or blocks of 3-60 amino acids in length, compiled from the PROSITE database (Henikoff; supra; Bairoch, supra), and those in PRINTS, a protein fingerprint database based on non-redundant sequences obtained from sources such as SwissProt, GenBank, PIR, and NRL-3D (Attwood et al. (1997) J Chem Inf Comput Sci 37:417-424). For the purposes of the present invention, the BLIMPS searches reported matches with a cutoff score of 1000 or greater and a cutoff probability value of 1.0×10 −3 . HMM-based protocols were based on a probabilistic approach and searched for consensus primary structures of gene families in the protein sequences (Eddy, supra; Sonnhammer, supra). More than 500 known protein families with cutoff scores ranging from 10 to 50 bits were selected for use in this invention.

VII Labeling of Probes and Hybridization Analyses

Substrate Preparation

Polynucleotides are isolated from a biological source and applied to a substrate for standard hybridization protocols by one of the following methods. A mixture of target nucleic acids, a restriction digest of genomic DNA, is fractionated by electrophoresis through an 0.7% agarose gel in 1×TAE [Tris-acetate-ethylenediamine tetraacetic acid (EDTA)] running buffer and transferred to a nylon membrane by capillary transfer using 20× saline sodium citrate (SSC). Alternatively, the target nucleic acids are individually ligated to a vector and inserted into bacterial host cells to form a library. Target nucleic acids are arranged on a substrate by one of the following methods. In the first method, bacterial cells containing individual clones are robotically picked and arranged on a nylon membrane. The membrane is placed on bacterial growth medium, LB agar containing carbenicillin, and incubated at 37° C. for 16 hours. Bacterial colonies are denatured, neutralized, and digested with proteinase K. Nylon membranes are exposed to UV irradiation in a STRATALINKER UV-crosslinker (Stratagene) to cross-link DNA to the membrane.

In the second method, target nucleic acids are amplified from bacterial vectors by thirty cycles of PCR using primers complementary to vector sequences flanking the insert. Amplified target nucleic acids are purified using SEPHACRYL-400 beads (Amersham Pharmacia Biotech). Purified target nucleic acids are robotically arrayed onto a glass microscope slide (Coming Science Products, Coming N.Y.). The slide is previously coated with 0.05% aminopropyl silane (Sigma-Aldrich, St. Louis Mo.) and cured at 110° C. The arrayed glass slide (microarray) is exposed to UV irradiation in a STRATALINKER UV-crosslinker (Stratagene).

Probe Preparation

cDNA probes are made from mRNA templates. Five micrograms of mRNA is mixed with 1 μg random primer (Life Technologies), incubated at 70° C. for 10 minutes, and lyophilized. The lyophilized sample is resuspended in 50 μl of 1× first strand buffer (cDNA Synthesis systems; Life Technologies) containing a dNTP mix, [α- 32 P]dCTP, dithiothreitol, and MMLV reverse transcriptase (Stratagene), and incubated at 42° C. for 1-2 hours. After incubation, the probe is diluted with 42 μl dH 2 O, heated to 95° C. for 3 minutes, and cooled on ice. mRNA in the probe is removed by alkaline degradation. The probe is neutralized, and degraded mRNA and unincorporated nucleotides are removed using a PROBEQUANT G-50 microcolumn (Amersham Pharmacia Biotech). Probes can be labeled with fluorescent markers, Cy3-dCTP or Cy5-dCTP (Amersham Pharmacia Biotech), in place of the radionucleotide, [ 32 P]dCTP.

Hybridization

Hybridization is carried out at 65° C. in a hybridization buffer containing 0.5 M sodium phosphate (pH 7.2), 7% SDS, and 1 mM EDTA. After the substrate is incubated in hybridization buffer at 65° C. for at least 2 hours, the buffer is replaced with 10 ml of fresh buffer containing the probes. After incubation at 65° C. for 18 hours, the hybridization buffer is removed, and the substrate is washed sequentially under increasingly stringent conditions, up to 40 mM sodium phosphate, 1% SDS, 1 mM EDTA at 65° C. To detect signal produced by a radiolabeled probe hybridized on a membrane, the substrate is exposed to a PHOSPHORIMAGER cassette (Amersham Pharmacia Biotech), and the image is analyzed using IMAGEQUANT data analysis software (Amersham Pharmacia Biotech). To detect signals produced by a fluorescent probe hybridized on a microarray, the substrate is examined by confocal laser microscopy, and images are collected and analyzed using GEMTOOLS gene expression analysis software (Incyte Pharmaceuticals).

VIII Complementary Polynucleotides

Molecules complementary to the polynucleotide, or a fragment thereof, are used to detect, decrease, or inhibit gene expression. Although use of oligonucleotides comprising from about 15 to about 60 base pairs is described, the same procedure is used with larger or smaller fragments or their derivatives (PNAs). Oligonucleotides are designed using OLIGO 4.06 software (National Biosciences) and SEQ ID NOs: 1-169 or fragments thereof. To inhibit transcription by preventing promoter binding, a complementary oligonucleotide is designed to bind to the most unique 5′ sequence, most preferably about 10 nucleotides before the initiation codon of the open reading frame. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding to the mRNA encoding the polypeptide.

IX Production of Specific Antibodies

The polypeptides encoded by SEQ ID NOs: 1-1 69, or portions thereof, substantially purified using polyacrylamide gel electrophoresis or other purification techniques, are used to immunize rabbits and to produce antibodies using standard protocols as described in Pound (1998; Immunochemical Protocols, Methods Mol. Biol. Vol. 80).

Alternatively, the amino acid sequence is analyzed using LASERGENE software (DNASTAR, Madison Wis.) to determine regions of high immunogenicity, and a corresponding oligopeptide is synthesized and used to raise antibodies by means known to those of skill in the art. Methods for selection of epitopes, such as those near the C-terminus or in hydrophilic regions are well described in the art. Typically, oligopeptides 15 residues in length are synthesized using an ABI 431A Peptide synthesizer (PE Biosystems) using fmoc-chemistry and coupled to keyhole limpet hemocyanin (KLH, Sigma-Aldrich) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester (Ausubel supra) to increase immunogenicity. Rabbits are immunized with the oligopeptide-KLH complex in complete Freund's adjuvant. Resulting antisera are tested for antipeptide activity by, for example, binding the peptide to plastic, blocking with 1% BSA, reacting with rabbit antisera, washing, and reacting with radio-iodinated goat anti-rabbit IgG.

X Screening Molecules for Specific Binding with the Polynucleotide or Polypeptide

The polynucleotide, or fragments thereof, or the polypeptide, or portions thereof, are labeled with 32 P-dCTP, Cy3-dCTP, or Cy5-dCTP (Amersham Pharmacia Biotech), or with BIODIPY or FITC (Molecular Probes, Eugene Oreg.), respectively. Libraries of candidate molecules previously arranged on a the substrate are incubated in the presence of labeled polynucleotide or polypeptide. After incubation under conditions for either a nucleic acid or amino acid sequence, the substrate is washed, and any position on the substrate retaining label, which indicates specific binding or complex formation, is assayed, and the binding molecule is identified. Data obtained using different concentrations of the polynucleotide or polypeptide are used to calculate affinity between the labeled nucleic acid or protein and the bound molecule.

1

gttttgccta ccatcgtgac atctccatgg ctgtaccacc ttgtcgggta gcttatcaga 60

ctgatgttga ctgttgaatc tcatggcaac accagtcgat gggctgtctg acattttggt 120

atctttcatc tgaccatcca tatccaatgt tctcatttaa acattaccca gcatcattgt 180

ttataatcag aaactctggt ccttctgtct ggtggcactt agagtctttt gtgccataat 240

gcagcagtat ggagggagga ttttatggag aaatggggat agtcttcatg accacaaata 300

aataaaggaa aactaagctg cattgtgggt tttgaaaagg ttattatact tcttaacaat 360

tctttttttc agggactttt ctagctgtat gactgttact tgaccttctt tgaaaagcat 420

tcccaaaatg ctctatttta gatagattaa cattaaccaa cataattttt tttagatcga 480

gtcagcataa atttctaagt cagcctctag tcgtggttca tctctttcac ctgcatttta 540

tttggtgttt gtctgaagaa aggaaagagg aaagcaaata cgaattgtac tatttgtacc 600

aaatctttgg gattcattgg caaataattt cagtgtggtg tattattaaa tagaaaaaaa 660

aaattttgtt tcctaggttg aaggtctaat tgatacgttt gacttatgat gaccatttat 720

gcactttcaa atgaatttgc tttcaaaata aatgaagagc agctgtcctt ctttcctctt 780

ttaagtgttc agctgtggca tgctcagagg ttcctgctgg attccagctg gagcggtgtg 840

atacccttct ttttcagctg ttcgtgcctt cctttcttgt atccaccaaa gtggagacaa 900

atacatgatc tcaaagatac acagtaccta cttaattcca gctgatggga gaccaaagaa 960

tttgcaagtg gatggtttgg tatcactgta aataaaaaga gggcctggga attcttgcga 1020

ttccatctct actttgtata agtctcattt tgtgccttac acatctgcag tatttatcat 1080

gttccaactt ggtgactgtc aggcagtgca atacatcagc agtttatcac cgaagagctg 1140

aggaatacct cccttaaaac agacaatgtc 1170

2

taagttaccc cgatgacttg gtttggaagg ggttaaggca ccagtcatcc tcttctaaag 60

tgatttatga tgatgtgtgg agtttaaaaa ctttacccca ccccaaagaa cagccctctc 120

actcctcact gagtccactc tgaacgtgct aaaatgggaa ggaggcggtg ttttgatgat 180

ctgttaaatt cttagtgaag tttccttgat ttccagtggc tgctgttgtt tgagtttggt 240

ttggagcaaa actgaggtag tcctaacatt tctgggactg aatccaggca agagaaagaa 300

gaaaaagaag aagaaaaaga ggaggaaaaa ggtagggaga aataaaggga ggagagaagc 360

acagtgaaaa aaaaaaaaag tcccttttcg acatcacatt cctgtgtttt ccctcagcct 420

ggaaaacata tgaatcccag tgcttttacg cccggaaaca aagagactaa gccagactat 480

gggggaaagg gagataagaa ggatcctgga actttaaaga gggaaagagt gagattcaga 540

aatcgccagg actggacttt aagggacgtc ctgtgtcagc acaagggact ggcacacaca 600

gacacacgag accgaggaga aactgcagac aaatggagat acaaagactt agaaggacag 660

ctcctttcac ctcatcctac ttgtccagaa ggtaaaaaga cacagccaga aagaaaaggc 720

atcggctcag ctctcagatc aggacaggct gtggatctgt ggcggtactc tgaaagctgg 780

agctgcagca cacccctttt gtattgctca ccctcggtaa agagagagag ggctgggagg 840

aaaagtagtt catctaggaa actgtcctgg gaaccaaact tctgatttct tttgcaaccc 900

tctgcattcc atctctatga gccaccattg gattacacaa tgacatggag aatgggaccc 960

cgtttcacta tgctgttggc catgtggcta gtgtgtggat cagaacccca cccccatgcc 1020

actattagag gcagccacgg aggacggaaa gtgcctttgg tttctccgga cagcagtagg 1080

ccagctcggt ttctgaggca cactgggagg tctcgcggaa ttgagagatc cactctggag 1140

gaaccaaacc ttcagcctct ccagagaagg aggagtgtgc ccgtgttgag actagctcgc 1200

ccaacagagc cgccagcccg ctcggacatc aatggggccg ccgtgagacc tgagcaaaga 1260

ccagcagcca ggggctctcc gcgtgagatg atcagagatg aggggtcctc agctcggtca 1320

agaatgttgc gtttcccttc ggggtccagc tctcccaaca tccttgccag ctttgcaggg 1380

aagaacagag tatgggtcat ctcagcccct catgcctcgg aaggctacta ccgcctcatg 1440

atgagcctgc tgaaggacga tgtgtactgt gagctggcgg agaggcacat ccaacagatt 1500

gtgctcttcc accaggcagg tgaggaagga ggcaaggtga gaaggatcac cagcgagggc 1560

cagatcctgg agcagcccct ggaccctagc ctcatcccta agctgatgag cttcctgaag 1620

ctggagaagg gcaagtttgg catggtgctg ctgaagaaga cgctgcaggt ggaggagcgc 1680

tatccatatc ccgttaggct ggaagccatg tacgaggtca tcgaccaagg ccccatccgt 1740

aggatcgaga agatcaggca gaagggcttt gtccagaaat gtaaggcctc tggtgtagag 1800

ggccaggtgg tggcggaggg gaatgacggt ggagggggag caggaaggcc aagcctgggc 1860

agcgagaaga agaaagagga cccaaggaga gcacaagtcc caccaaccag agagagtcgg 1920

gtgaaggtcc tgagaaaact ggccgccact gcaccagctt tgccccaacc tccctcaacc 1980

cccagagcca ccacccttcc tcctgcccca gccacaacag tgactcggtc cacgtcccgg 2040

gcggtaacag ttgctgcaag acctatgacc accactgcct ttcccaccac gcagaggccc 2100

tggaccccct caccctccca caggccccct acaaccactg aggtgatcac tgccaggaga 2160

ccctcagttt cagagaatct ttaccctcca tcccggaagg atcagcacag ggagaggcca 2220

cagacaacca ggaggcccag caaggccacc agcttggaga gcttcacaaa tgcccctccc 2280

accaccatct cagaacccag cacaagggct gctggcccag gccgtttccg ggacaaccgc 2340

atggacaggc gggaacatgg ccaccgagac ccaaatgtgg tgccaggtcc tcccaagcca 2400

gcaaaggaga aacctcccaa aaagaaggcc caggacaaaa ttcttagtaa tgagtatgag 2460

gagaagtatg acctcagccg gcctactgcc tctcagctgg aggacgagct gcaggtgggg 2520

aatgttcccc ttaaaaaagc aaaggagtct aaaaagcatg aaaagcttga gaaaccagag 2580

aaggagaaga aaaaaaagat gaagaatgag aacgcagaca agttacttaa gagtgaaaag 2640

caaatgaaga agtctgagaa aaagagcaag caagagaaag agaagagcaa gaagaaaaaa 2700

ggaggtaaaa cagaacagga tggctatcag aaacccacca acaaacactt cacgcagagt 2760

cccaagaagt cagtggccga cctgctgggg tcctttgaag gcaaacgaag actccttctg 2820

atcactgctc ccaaggctga gaacaatatg tatgtgcaac aacgtgatga atatctggaa 2880

agtttctgca agatggctac caggaaaatc tctgtgatca ccatcttcgg ccctgtcaac 2940

aacagcacca tgaaaatcga ccactttcag ctagataatg agaagcccat gcgagtggtg 3000

gatgatgaag acttggtaga ccagcgtctc atcagcgagc tgaggaaaga gtacggaatg 3060

acctacaatg acttcttcat ggtgctaaca gatgtggatc tgagagtcaa gcaatactat 3120

gaggtaccaa taacaatgaa gtctgtgttt gatctgatcg atactttcca gtcccgaatc 3180

aaagatatgg agaagcagaa gaaggagggc attgtttgca aagaggacaa aaagcagtcc 3240

ctggagaact tcctatccag gttccggtgg aggaggaggt tgctggtgat ctctgctcct 3300

aacgatgaag actgggccta ttcacagcag ctctctgccc tcagtggtca ggcgtgcaat 3360

tttggtctgc gccacataac cattctgaag cttttaggcg ttggagagga agttggggga 3420

gtgttagaac tgttcccaat taatgggagc tctgttgttg agcgagaaga cgtaccagcc 3480

catttggtga aagacattcg taactatttt caagtgagcc cggagtactt ctccatgctt 3540

ctagtcggaa aagacggaaa tgtcaaatcc tggtatcctt ccccaatgtg gtccatggtg 3600

attgtgtacg atttaattga ttcgatgcaa cttcggagac aggaaatggc gattcagcag 3660

tcactgggga tgcgctgccc agaagatgag tatgcaggct atggttacca tagttaccac 3720

caaggatacc aggatggtta ccaggatgac taccgtcatc atgagagtta tcaccatgga 3780

tacccttact gagcagaaat atgtaacctt agactcagcc agtttcctct gcagctgcta 3840

aaactacatg tggccagctc cattcttcca cactgcgtac tacatttcct gcctttttct 3900

ttcagtgttt ttctaagact aaataaatag caaactttca cctattcatg agttattatt 3960

gaaacctcaa atcataaaga catttaaaag aattgttttt ctaactggag gggctctagt 4020

gctaaataat agtactgaaa attgatatta ttttcctttt cttatatgaa ggaccttatt 4080

tggcatataa aattttataa aatatgtaaa aaaaaaa 4117

3

agaaatatca tatggttact ttggtatctg acacagccat gacaccaatt gctagtgtag 60

acacaatagc tgtgtgtctt tttgcaggag cctggggagg ggccatggtg ccaatgcact 120

tactggggag actggagaag ccgcttctcc tcctgtgctg cgcctccttc ctactggggc 180

tggctttgct gggcataaag acggacatca cccccgttgc ttatttcttt ctcacattgg 240

gtggcttctt cttgtttgcc tatctcctgg tccggtttct ggaatggggg cttcggtccc 300

agctccaatc aatgcagact gagagcccag ggccctcagg caatgcacgg gacaatgaag 360

cctttgaagt gccagtctat gaagaggccg tggtgggact agaatcccag tgccgccccc 420

aagagttgga ccaaccaccc ccctacagca ctgttgtgat acccccagca cctgaggagg 480

aacaacctag ccatccagag gggtccagga gagccaaact ggaacagagg cgaatggcct 540

cagaggggtc catggcccag gaaggaagcc ctggaagagc tccaatcaac cttcggcttc 600

ggggaccacg ggctgtgtcc actgctcctg atctgcagag cttggcggca gtccccacat 660

tagagcctct gactccaccc cctgcctatg atgtctgctt tggtcaccct gatgatgata 720

gtgtttttta tgaggacaac tgggcacccc cttaaatgac tctcccaaga tttctcttct 780

ctccacacca gacctcgttc atttgactaa cattttccag cgcctactat gtgtcagaaa 840

caagtgtttc tgcctggaca tcataaatgg ggacttggac cctgaggaga gtcaggccac 900

ggtaagccct tcccagctga gatatgggtg gcataatttg agtcttctgg caacatttgg 960

tgacctaccc catatccaat atttccagcg ttagattgag gatgaggtag ggaggtgatc 1020

cagagaaggc ggagaaggaa gaagtaacct ctgagtggcg gctattgctt ctgttccagg 1080

tgctgttcga gctgttagaa cccttaggct tgacagcttt gtgagttatt attgaaaaat 1140

gaggattcca agagtcagag gagtttgata atgtgcacga gggcacactg ctagtaaata 1200

acattaaaat aactcgaatg ac 1222

4

cggacccaaa ggagcaaaag gagattccag aacaatcaca accaaaggtg agcggggaca 60

gcccggcgtc ccaggtgtgc ccgggatgaa aggtgacgat ggcagcccag gccgcgatgg 120

gctcgatgga ttccccggcc tcccaggccc tcccggtgat ggcatcaagg gccctccagg 180

ggacccaggc tatccaggaa tacctggaac gaagggtact ccaggagaaa tgggcccccc 240

aggactgggc cttcccggcc tcaaaggcca acgtggtttc cctggagacg ccggcttacc 300

tggaccacca ggcttcctgg gccctcctgg ccccgcagga ccccaggaca aatagattgt 360

gacacagatg tgaaaagggc cgttggaggt gacagacagg aggccatcca gccaggttgc 420

ataggagggc ccaagggatt gccaggcctg ccaggacccc caggccccac aggtgccaaa 480

ggcctccgag gaatcccagg cttcgcagga gctgatggag gaccagggtc caggggcttg 540

ccaggagacg caggtcgtga agggttccca ggacccccag ggttcatagg accccgagga 600

tccaaaggtg cagtgggcct ccctggccca gatggatccc caggtcccat cggcctgcca 660

gggccagatg ggccccctgg ggaaaggggc ctccctggag aagtcctggg agctcagccc 720

gggccacggg gagatgctgg tgtgcctgga cagcctgggc ttaaaggcct tcccggagac 780

agaggccccc ctggattcag aggaagccaa gggatgcctg ggatgccagg gctgaagggc 840

cagccaggcc tcccaggacc ttccggccag ccaggcctgt atgggcctcc aggactgcat 900

ggattcccag gagctcctgg ccaagagggg cccttggggc tgccaggaat cccaggccgt 960

gaaggtctgc ctggtgatag aggggaccct ggggacacag gcgctcctgg ccctgtgggc 1020

atgaaaggtc tctctggtga cagaggagat gctggcttca caggggagca aggccatcca 1080

ggaagccctg gatttaaagg aattgatgga atgcctggga cccccgggct aaaaggagat 1140

agaggctcac ctgggatgga tggtttccaa ggcatgcctg gactcaaagg gagacccggg 1200

tttccaggga gcaaaggcga ggctggattt ttcggaatac ccggtctgaa gggtctggct 1260

ggtgagccag gttttaaagg cagccgaggg gaccctgggc ccccaggacc acctcctgtc 1320

atcctgccag gaatgaaaga cattaaagga gagaaaggag atgaagggcc tatggggctg 1380

aaaggatacc tgggcgcaaa aggtatccaa ggaatgccag gcatcccagg gctgtcagga 1440

atccctgggc tgcctgggag gcccggccac atcaaaggag tcaagggaga catcggagtc 1500

cccggcatcc ccggtttgcc aggattccct ggggtggctg gcccccctgg aattacggga 1560

ttcccaggat tcataggaag ccggggtgac aaaggtgccc cagggagagc aggcctgtat 1620

ggcgagattg gcgcgactgg tgatttcggt gacatcgggg acactataaa tttaccagga 1680

agaccaggcc tgaaggggga gcggggcacc actggaatac caggtctgaa gggattcttt 1740

ggagagaagg gaacagaagg tgacatcggc ttccctggga taacaggcgt gactggagtc 1800

caaggccctc ctggacttaa aggacaaaca ggctttccag ggctgactgg gcctccaggg 1860

tcgcagggag agctggggcg gattggactg cctggtggca aaggagatga tggctggccg 1920

ggagctccgg gcttaccagg ttttccggga ctccgtggga tccgcggctt acacggcttg 1980

ccaggcacca agggctttcc aggatcccca ggttctgaca tccacggaga cccaggcttc 2040

ccaggccctc ctggggaaag aggtgaccca ggagaggcca acacccttcc aggccctgtg 2100

ggagtcccag gacagaaagg agaccaagga gctccagggg aacgaggccc acctgggagc 2160

ccaggacttc aggggttccc aggcatcaca cccccttcca acatctctgg ggcacctggt 2220

gacaaagggg cgccagggat atttggcctg aaaggttatc ggggcccacc agggccacca 2280

ggttctgctg ctcttcctgg aagcaaaggt gacacaggga acccaggagc tccaggaacc 2340

ccagggacca aaggatgggc cggggactcc gggccccagg gcaggcctgg tgtgtttggt 2400

ctcccaggag aaaaagggcc caggggtgaa caaggcttca tggggaacac tggacccacc 2460

ggggcggtgg gcgacagagg ccccaaggga cccaagggag acccaggatt ccctggtgcc 2520

cccgggactg tgggagcccc cgggattgca ggaatccccc agaagattgc cgtccaacca 2580

gggacagtgg gtccccaggg gaggcgaggc ccccctgggg caccggggga gatggggccc 2640

cagggccccc ccggagaacc aggttttcgt ggggctccag ggaaagctgg gccccaagga 2700

agaggtggtg tgtctgctgt tcccggcttc cggggagatg aaggacccat aggccaccag 2760

gggccgattg gccaagaagg tgcaccaggc cgtccaggga gcccgggcct gccgggtatg 2820

ccaggccgca gcgtcagcat cggctacctc ctggtgaagc acagccagac ggaccaggag 2880

cccatgtgcc cggtgggcat gaacaaactc tggagtggat acagcctgct gtacttcgag 2940

ggccaggaga aggcgcacaa ccaggacctg gggctggcgg gctcctgcct ggcgcggttc 3000

agcaccatgc ccttcctgta ctgcaaccct ggtgatgtct gctactatgc cagccggaac 3060

gacaagtcct actggctctc taccactgcg ccgctgccca tgatgcccgt ggccgaggac 3120

gagatcaagc cctacatcag ccgctgttct gtgtgtgagg ccccggccat cgccatcgcg 3180

gtccacagtc aggatgtctc catcccacac tgcccagctg ggtggcggag tttgtggatc 3240

ggatattcct tcctcatgca cacggcggcg ggagacgaag gcggtggcca atcactggtg 3300

tcaccgggca gctgtctaga ggacttccgc gccacaccat tcatcgaatg caatggaggc 3360

cgcggcacct gccactacta cgccaacaag tacagcttct ggctgaccac cattcccgag 3420

cagagcttcc agggctcgcc ctccgccgac acgctcaagg ccggcctcat ccgcacacac 3480

atcagccgct gccaggtgtg catgaagaac ctgtgagccg gcgcgtgcca ggaagggcca 3540

ttttggtgct tattcttaac ttattacctc aggtgccaac ccaaaaattg gttttatttt 3600

tttcttaaaa aaaaaaaagt ctaccaaagg aatttgcatc cagcagcagc acttagacct 3660

gccagccact gtcaccgagc gggtgcaagc actcggggtc cctggagggc aagccctgcc 3720

cacagaaagc caggagcagc cctggccccc atcagccctg ctagacgcac cgcctgaagg 3780

cacagctaac cacttcgcac acacccatgt aaccactgca ctttccaatg ccacagacaa 3840

ctcacattgt tcaactccct tctcggggtg ggacagacga gacaacagca cacaggcagc 3900

cagccgtggc cagaggctcg aggggctcag gggctcaggc acccgtcccc acacgagggc 3960

cccgtgggtg ggcctggccc tgctttctac gccaatgtta tgccagctcc atgttctccc 4020

aaataccgtt gatgtgaatt attttaaagg caaaactgtg ctctttattt taaaaaacac 4080

tgataatcac actgcggtag gtcattcttt tgccacatcc ctatagacca ctgggtttgg 4140

caaaactcag gcagaagtgg agacctttct agacatcact gtcagccttg ctacttgaag 4200

gtacacccca tagggtcgga ggtgctgtcc ccactgcccc acgttgtccc tgagatttaa 4260

cccctccact gctgggggtg agctgtactc ttctgactgc cccctcctgt gtaacgacta 4320

caaaataaaa cttggttctg aatattttta aaaaaaaaa 4359

5

cggggcgggg ctgagcgtgt ttacatccgc cgggtgcgcg gcttcgccgc ccgaggtcgt 60

tcggctcggg taccatcctc cgcgccatgg acaccagcga cctgttcgcc agctgcagga 120

agggggatgt gggccgagtg cggtacctgc tggagcagcg agacgtggag gtactatgcc 180

tgcttgtgtg ggcacgagga gctggtactc taccttctgg ccaatggagc ccgctgcgag 240

gccaacacct tcgatggtga gcgctgcctc tatggggcac tgagtgaccc catccgccgg 300

gctctacgcg attacaagca ggtcacggct tcctgcagga ggcgggatta ctatgacgac 360

ttcttgcagc ggcttctaga gcagggcatc cacagtgacg tggtctttgt agtacacggg 420

aagccattcc gggtgcatcg ctgcgtcctg ggtgcacgta gcgctacttt gccaacatgc 480

tggacaccaa atggaagggc aagagtgtcg tggttctcag gcacccactg atcaaccccg 540

tggcctttgg ggccctgctg cagtacctgt acacaggccg cctggacatt ggcgtagagc 600

atgtgagtga ctgtgagcgc ctggccaagc aatgccagct gtgggacctg ctcagcgacc 660

tggaggccaa gtgcgagaag gtgtctgagt ttgtggcgtc taagccaggc acgtgtgtga 720

aggtgctgac catcgagccc ccacctgcag acccccgcct ccgggaggac atggcgctgc 780

tggccgattg tgccctgccc cccgagctcc gaggtgatct ttgggagctg cccttccctt 840

gtcctgacgg cttcaacagc tgccctgaca tctgcttccg agtggctggc tgcagcttcc 900

tctgccacaa ggcctttttc tgtggccgca gtgactactt ccgagccctg ctggatgacc 960

acttccgaga gagcgaggag ccagcgacct cagggggccc cccagccgtc accctgcatg 1020

gcatctcacc cgacgtcttc actcacgtgc tctactacat gtacagcgac cacactgagc 1080

tgtcccccga ggcagcctat gatgtgctga gcgtcgccga catgtacctg ctgccaggcc 1140

tgaagaggct gtgcggccgc agcctggctc agatgctaga cgaggacact gtggtgggtg 1200

tgtggcgcgt ggccaagctc ttccgcctgg cgcggcttga ggaccagtgc actgagtaca 1260

tggccaaggt cattgagaag ctggtggagc gggaggactt cgtggaggcg gtgaaggagg 1320

aggcagcggc tgtggcagcc cggcaggaga cggactctat cccgctggtg gacgacatcc 1380

gcttccacgt ggccagcacg gtgcagacct acagcgccat agaggaggcg cagcagcgtc 1440

tgcgggcact cgaggacctg ctcgtgtcca tcggtctgga ctgttgagcc cctggctggg 1500

cagccccagg ggccaggagc tctcttggag acaagcatgt gtatgcgttt gtgtgcagct 1560

cttcttcctg ctccctgcac attgagggct tcatgggggg tgcgaggggc tcagtggggc 1620

ttctcttccc tccatgagcc tggagacccc aggggaggat ccatttggga tgagccccct 1680

ccccccaatg cacaagccag cccccaagac cctgggggtg gacaccactc agggaaacct 1740

ggggtggggg tgggctttgg tcttagcact ttccttctcc agatcccccc tacccacccc 1800

agtcccaaat ccagtcctct ggcccttgcc tagccctgaa ttgcttctct aagctggtgt 1860

tcccatgcac agggccattc aggaagggct gggggagtgt gtgtggcaat aaagcttgaa 1920

ggcaccgtgg gaaaaaaaaa aaaaaa 1946

6

tttttttcat attttgtgtg ctgatttttt aatgaacaac ttataatctt acaaaataac 60

tggctgtagc tgttttacat tacaatacag tagatcagct cctttcacta cattcccaat 120

caagccatcc ccttgggtgt taactaatgc actcaatagt gatcacaaag aatacaggaa 180

gtgccaagtt caatgccttg taatagaaaa aagagaagat gagaatcagg aagagctctt 240

tactttcaca atccctttac tttaatttct gtcagtatct gcccattctc ctcaccctgt 300

ccccttacct gcctttctga ttggaggctg tcatgctagt tgttagagcc agctagccct 360

gggccacctg ggcacaatca aacacacaga agagtctctg agaaaggctc tcaatgacca 420

catgggtgga taagagtagc agaatgtgga ccaccacatg gattgagtgt gagttgatgt 480

tgctgggatc tgtgaccaca gtgtcttagt ccttccactt tatcagtgac ctgagttgct 540

caaaacatca ggtcccagga acaaagactg gaagaacctg ctgtctctga atagctatag 600

ctgactatgg ctgggaagcc ttatagccta agaggctctt cacacacaac aggaactttc 660

cttttgcttt cccagagcag tggtgaattg cagataataa aatattttaa aatgaaattt 720

aaaacagaaa tgttcttact gttgctcttg tggagagact gcatgaagac acacactggc 780

atgaaccaca ggctccatgt tcctgagctg agtaatgccc aggataacaa ttcctctgcc 840

tcaatctcag acaaagtagg attctccaag gcagaactta gaatgtgtct agcaatttgg 900

acattttccc caataaaaca agtttataaa attttgaaaa tagagtgtct aaacttttcc 960

attgtcctta gcgtattgaa gcctatcaga atcccaagaa taaatatgtt tgtcttcttg 1020

ggggcactaa gcatgaccca agacaatgaa tggtatctga actacatttt ctttacacta 1080

gagattagta gacaaaaggt tttttttgaa tgggtgaact ctgctctttc cttttcccaa 1140

taactttgca accctcattc cacaaaccca cagattaatg tgggtacatc accttattcg 1200

tgttttattc tctttcagga tattgttctt ccctacgtga tagtgtggat aatatttcta 1260

tcattgtggt agtatttcct attcctattt gcacagccat tgctctagtg ttgatgggaa 1320

gagtagaaaa actgtggtca aagcaaaaga gcagaagatg agaagagacc acagctgagc 1380

tctaaatttt gtctgttctt ggtttccatt ggagaagaaa ctttaaagga gacaagcctc 1440

acagccttcc taaaatgagt aaaactagaa tgttaaacag aaactggctc cttactcact 1500

ttccctaggg tctaatccag aaaccgttac aagaaaatgt aactgcagta gaccacatcc 1560

cagtgagcct gggatgtaaa tagagagagg cttaatatgg tcatttcatg tgcattccat 1620

ctattggata agaaagggta aaaacaacaa aatggacatt aaatagttga aattcttctg 1680

tctccccaca gagtgtcacc cttgctccat gcatttccat ggcttgctca agtcaaaatc 1740

tctggctcac agattttgta catgatactt gaagagaatt tatctcagat tcttcattgc 1800

tcaagggacc cactttggtc ttctttggag acttggaaca aggaccgagt ctccctgatn 1860

acttccattc tcatgcccgg gcctggattt aaccctgaca gntcttgcan tgttct 1916

7

attcctgatt tgcctttgcc atataatcta atgcttgttt atatagtgtc tggtattgtt 60

taacagttct gtcttttcta tttaaatgcc actaaatttt aaattcatac ctttccatga 120

ttcaaaattc aaaagatccc atgggagatg gttggaaaat ctccacttca tcctccaagc 180

cattcaagtt tcctttccag aagcaactgc tactgccttt cattcatatg ttcttctaaa 240

gatagtctac atttggaaat gtatgttaaa agcacgtatt tttaaaattt ttttcctaaa 300

tagtaacaca ttgtatgtct gctgtgtact ttgctatttt tatttatttt agtgtttctt 360

atatagcaga tggaatgaat ttgaagttcc cagggctgag gatccatgcc ttctttgttt 420

ctaagttatc tttcccatag cttttcatta tctttcatat gatccagtat atgttaaata 480

tgtcctacat atacatttag acaaccacca tttgttaagt atttgctcta ggacagagtt 540

tggatttgtt tatgtttgct caaaaggaga cccatgggct ctccagggtg cactgagtca 600

atctagtcct aaaaagcaat cttattatta actctgtatg acagaatcat gtctggaact 660

tttgttttct gctttctgtc aagtataaac ttcactttga tgctgtactt gcaaaatcac 720

attttctttc tggaaattcc ggcagtgtac cttgactgct agctaccctg tgccagaaaa 780

gcctcattcg ttgtgcttga acccttgaat gccaccagct gtcatcacta cacagccctc 840

ctaagaggct tcctggaggt ttcgagattc agatgccctg ggagatccca gagtttcctt 900

tccctcttgg ccatattctg gtgtcaatga caaggagtac cttggctttg ccacatgtca 960

aggctgaaga aacagtgtct ccaacagagc tccttgtgtt atctgtttgt acatgtgcat 1020

ttgtacagta attggtgtga cagtgttctt tgtgtgaatt acaggcaaga attgtggctg 1080

agcaaggcac atagtctact cagtctattc ctaagtccta actcctcctt gtggtgttgg 1140

atttgtaagg cactttatcc cttttgtctc atgtttcatc gtaaatggca taggcagaga 1200

tgatacctaa ttctgcattt gattgtcact ttttgtacct gcattaattt aataaaatat 1260

tcttatttat tttgttactt ggtacaccag catgtccatt ttcttgttta ttttgtgttt 1320

aataaaatgt tcagtttaac atcccagtgg agaaagttaa aa 1362

8

cgttagtcct taaaacacaa cggacacgtc gtccccgtcc cagacccaaa actacatcaa 60

gtcctgaagt acctcagaac aaatcggttt ctgttacagg ctttgaacct gttgttcata 120

gtactgatgc tccaggaaca acatttgctc tgactgaact gcaaactctt attttgaaac 180

cagtgacatc accaagccta gaaatgacag aaagtcaacc tgtttctgat gggttctgga 240

atcggttaca cttagtactg agtcaccaaa ggagaccata gcaccagcca aaacagacta 300

tgtatatccc actgccaaag caccactctg gccagaggag ccaaagactg aagttgtgga 360

atctattaca tatgtatctg aaccacctga gaccacacta gaaacgtcgc ctctgccttc 420

tcaatctata accctaccca gcccagatga gcctcagact gaacctgctc ccaagcagac 480

accacgtgct cctcctaagc caaaaacatg caccacgccc aagaatccca caaacacaac 540

cagttcctaa ggtgccccag cgtgttactg caaaaccaaa aacgtcacca agtccagaag 600

tgtcatacac cacacctgct ccaaaagatg tgctccttcc tcataaacca tacccncnag 660

gtntctcaga gcgaacctgc tcctctagag acacgaggca tcccttttat acccatgatt 720

tccccaagtc ctagtcaaga ggaactacag accactctgg aagaaacaga ccaatccacc 780

caagaacctt tcacaactaa gattccacga acaactgaac tagcaaagac aactcaggcg 840

ccacacagat tttatactac tgtgaggccc agaacatctg acaagccaca catcagacct 900

gttctgaata ggacaactac aagacctact aggcccaaac ccagtgggat gcccagtggg 960

aatggagtgg gaacaggggt caagcaagca cccaggccat caggtgctga tagaaatgta 1020

tcagtggact ctacccaccc cactaaaaag ccagggactc gccgcccacc cttgccaccc 1080

agacctacac acccacgaag aaaaccttta ccaccaaata atgtcactgg aaagccagga 1140

agtgcaggaa tcatttcatc agggcccaat aactacacca cccctgaggt caacacccag 1200

gcctactgga actcccttgg agagaataga gacagatata aagcaaccaa cagttcctgc 1260

ctctggagaa gaactggaaa atataactga ctttagctca agcccaacaa gagaaactga 1320

tcctcttggg aagccaagat tcaaaggacc tcatgtgcga tacatccaaa agcctgacaa 1380

cagtccctgc tccattactg actctgtcaa acggttcccc aaagaggagg ccacagaggg 1440

gaatgccacc agcccaccac agaacccacc caccaacctc actgtggtca ccgtggaagg 1500

gtgccccttc atttgtcatc ttggactggg aaaagccact aaatgacact gtcactgaat 1560

atgaagttat atccagagaa aatgggtcat tcagtgggaa gaacaagtcc attcaaatga 1620

caaatcagac attttccaca gtagaaaatc tgaaaccaaa cacgagttat gaattccagg 1680

tgaaacccaa aaacccgctt ggtgaaggcc cggtcagcaa cacagtggca ttcagtactg 1740

aatcagcgga cccaagagtg agtgagccag tttctgcagg aagagatgcc atctggactg 1800

aaagaccctt taattcagac tcttactcag agtgtaaggg caaacaatat gtcaaaagga 1860

catggtataa aaaatttgta ggagtgcagc tgtgcaactc tctcagatac aagatttact 1920

tgagcgactc cctcacagga aaattttata acataggtga tcagaggggc catggagaag 1980

atcactgcca gtttgtggat tcatttttag atggacgcac tgggcagcaa ctcacttctg 2040

accagttacc aatcaaagaa ggttatttca gagcagttcg ccaggaacct gtccaatttg 2100

gagaaatagg tggtcacacc caaatcaatt atgttcagtg gtatgaatgt gggactacaa 2160

ttcctggaaa atggtagatg ctgcacaaag ttaccttctg tttcatcatt gcaaacaaaa 2220

atcattgaaa atactatgcc gcattcattt aaagctattt tgtttactat gtataaaagt 2280

ctacaatcta attaatagca atactagatg tttattatta gaaaagattg ctgagagtat 2340

ttatcaggtt ttacaaagtc cattttaaga aagcaagata ctgatgttaa cagaataaca 2400

tttttgggga agctggctcc ctattcatgg tattttaaga gatcatttgt atattattta 2460

tcacactgtt gtaatgatgt tttgagatac ttttataaca aaattaacat caaaaaggta 2520

tatacttttt aaaaagtata tacttttatt gatgtgtact cttcctattg atgagttaat 2580

tccataaatc tctacttagt ttaacttatt ggatcaaatt atcttcagca tgtatatctg 2640

gggaaaaaag gtccgaattt tcacatttat atttaaactt caatttttta tatttaaact 2700

tcaatttttt agcaacagct gaatagcttt gcggaggagt ttaatagtta cacattcatg 2760

ctaatataca tttcctttaa acatccacaa attcttaaaa agattgaatc agtaaatttc 2820

atttcagcta aaaatggagt ctaatatatt gtttcaaaag atacattttt acccaccata 2880

aatgttacaa tatctgaata tgctttgtca aactatccct ttatgcaatc gtcttcatat 2940

tgtttttatg attctaatca agctgtatgt agagactgaa tgtgaagtca agtctgagca 3000

caaaaagata atgcacaatg agattgccta ccattttata ggatatttac tatgtattta 3060

tacgttaaga cctctatgaa tgatgtatca gagaatgtct ttgtaactaa ctgtttaatt 3120

caatctgtaa taaaaatcta actaactaac tcatttattt ctattaaaaa ggtattgtcc 3180

tttaggcggg gaatgggaat ccttgctgca ctgttgcagt cattctgaaa ggacctttcc 3240

ctgtacttac ctttcaacat gcttcaatct tatcaacgct acattttgta tttttcaaac 3300

aagtataaat tctgcaataa agagatgtag ttttttttta agattgagtt tttgtttgtt 3360

atttctgaat ggttcatcag tatgttaact atacctttta tcgagaagga aaatcactaa 3420

gttttattca ggctctacca acccccatta tatctactgt ttgtttatgt cctaaattaa 3480

cctttcatcc tatgaagtaa taaagttcat tttaaaccaa cg 3522

9

gacaacagcc ccacgtgacc ggccaacact gagtgttgtc tcgctctggc gtcagagccg 60

tcgtggctcg ttccattctc ggcggtggta cctgctcccg gtggccctga ggacgtgtgg 120

gccaggggcg gccccgaaat taggaagcgg agggggagca gtctgcaggt ctgcggggct 180

aagtgtcggc ggcggcgcac cttcgcgtca agaatccgga ggaggagact gcaaggatag 240

gcccaggagt aatggagtcc aaagaggaac tagcggcaaa caatctcaac ggggaaaatg 300

cccaacaaga aaacgaagga ggggagcagg cccccacgca gaatgaagaa gaatcccgcc 360

atttgggagg gggtgaaggc cagaagcctg gaggaaatat caggcggggg cgagttaggc 420

gacttgtccc taattttcga tgggccatac ctaataggca tattgagcac aatgaagcga 480

gagatgatgt agaacggttt gtagggcaga tgatggaaat caagagaaag actagggaac 540

agcagatgag gcactatatg cgcttccaaa ctcctgaacc tgacaaccat tatgactttt 600

gcctcatacc ttgaatccta aaagttttcg ctgaggttaa tgtgaacact gctttacaag 660

cttgtatttt tgtgatttac tttttctgta agccttttgg ggtttacact taccagtttc 720

taatggaaat tagaattcta attgaatatt gttttgtctc agcctaaaag ttacggtcag 780

catggcaatt cacctatttt aggaaaaata ctcttttcat aatatgaaat gcataaagca 840

gttcaaaaag cagtctgtat tccatcatct tcctttttca ttccagtcct tatttttgta 900

agtattactt ttcctcctcc ggctacctgg actcaaaatc tcagttgtct ttgacagttt 960

ttttcttgtc cctgaccaaa aaagaatgat catacccaga attcaatgtt tgatatttta 1020

agaatgtatg ttctagtgtt tttcagagtg agtctaccat ctgtataaaa acaccttggg 1080

ggcaggcagg ggcatttaaa aatgtaggac ctatcgtcca gactcacaga gtggggctcc 1140

agaatctcca tttttaacaa actctcttaa gtaattctga tgtgtaccaa aatcagtgcc 1200

attggtgtgt gtgtacgtaa ctatatacat atgtgtgtgt gtgtatatat ataatgtgtc 1260

ataaccgtaa acaataaaca atatcaagat aaatctgact ttgatgggca agtaattaaa 1320

aaagaaaagt atgagacctt 1340

10

gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg 60

gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc 120

gacctccgga gggaaccggc tccttgcgtc ccgcccgcgc agggagctcc gcacgggatt 180

tgcagattta cagaatggct gcacattaat ggaaagagaa gcataaacct atcttctttc 240

attatggagg gaggtttggc agatggggaa cctgatcgaa cttcgcaaac agtgacgaat 300

ctcagcttct gacaccagga aagatgagtc agcgccaagg aaaagaagct tatccaacgc 360

caaccaaaga tttgcatcag ccatctctta gtccagcaag tcctcatagc cagggttttg 420

aaagacggga agcgaacgat atcttctcca aaattaaacg atgaatcttc actttctatg 480

tcaaagagca aggtctgaat ctaaacttta taatggctca gagaaggaca gttcaacttc 540

aagcaaactc acaaaaaaag antctcttaa ggtacaaaag aaaaattacc gagaagaaaa 600

gaaaagagcc acaaaggagc tgctcagtac aatcacagat ccttctgtta ttgttatggc 660

tgattggtta aagattcgtg gtactctaaa gagctggacc aagttatggt gtgtgttgaa 720

acctggggtg ctactgatct ataaaaccca aaaaaatggt cagtgggtag gaacagttct 780

tctgaatgcc tgtgaaatca ttgaacgtcc atcaaaaaag gatggctttt gtttcaaact 840

tttccatcct ttggagcaat ctatttgggc agtgaagggt ccaaaaggtg aagcggttgg 900

atccattact caacccttac ctagcagtta tttgatcatc cgagctactt cacgagtccg 960

atgggaaggt gctgaatgga tgctttgaag ttggctttga aatgtcctag tctccttaaa 1020

ggtacaatga tcagagaagg aaaggaccat gacctgagcg tttcatcaga tagcacacat 1080

gtgacttcca atggcttact acgtgctacc aatctccaca gtggtgataa cttccagtta 1140

aatgatagtg aaattgaccg ccaacatttt aaggaccaag ata 1183

11

ccggtgcctg anattatgtg cggccccgcg ggctgctttc cgaggtcaga gtgccctgct 60

gctgtctcag aggcatctgt tctgcaaatc ttaggaagaa aaatgtccct agtagcaaac 120

gggtgtcttc tgtgcataaa taagtacaac acaattctcc gaaagttcgg gtaaaaagag 180

atgcggtagc agctgccctg tgtgaagctg tctaccccgc atctctcagg cgctaagctc 240

agtttttgtt tttgtttttg tttttttaaa gaaaagatgt ataattgcag gaattttttt 300

ttattttttt attttccatc attctatata tgtgatggtg aaagatatgc ctggaaaagt 360

tttgttttga aaagtttatt ttctgcttcg tcttcagttg gcaaaagctc tcaattcttt 420

agcttccagt ttcttttctc tctttttctt tgttaggtaa ttaaaggtat gtaaacaaat 480

tatctcatgt agcaggggat tttcatgttg agaggaatct tccgtgtgag ttgtttggtc 540

acacaaataa ccctttctca attttaggag tttggattgt caaatgtagg tttttctcaa 600

agggggcata taactacata ttgactgcca agaactatga ctgtagcact aatcagcaca 660

catagagcca cacaattatt taatttctaa ctctctgtgg tccctagaaa aattccgttg 720

atgtgcttag gttaaagttc tgaagatacc cgttgtaccc ttacttgaaa gtttctaatc 780

ttaagtttta tgaaatgcaa taatatgtat cagctagcaa tatttctgtg atcaccaaca 840

actctcagtt tgatcttaaa gtctgaataa taaaacaaat cccagcagta atacatttct 900

taaacctcac agtgcatgat atatcttttc attctgatcc tgtgtttgca aaaatataca 960

catgtatatc atagttcctc actttttatt catttgtttt cctattacct gtagtaaata 1020

tattagttag tacatggaat ttatagcatc agctaccccc aggaacagca cctgacaggc 1080

gggggatttt ttttcaagtt gttctacatt tgcataaatt atttctatta ttattcatgt 1140

atgttattta tttctgaatc acactagtcc tgtgaaagta caactgaagg cagaaagtgt 1200

taggattttg catctaatgt tcattatcat ggtattgatg gacctaagaa aataaaaatt 1260

agactaagcc cccaaataag ctgcatgcat ttgtaacatg attagtagat ttgaatatat 1320

agatgtagta ttttgggtat ctaggtgttt tatcattatg taaaggaatt aaagtaaagg 1380

actttgtagt tgtttttatt aaatatgcat atagtagagt gcaaaaatat agcaaaaata 1440

aaaactaaag gtagaaaagc attttagata tgccttaatt tagaaactgt gccaggtggc 1500

cctcgggaat agatgccagg cagagaccag tgcctgggtg gtgcctcctc ttgtctgccc 1560

tcatgaagaa gcttccctca cgtgatgtag tgcccctcgt aggtgtcatg tggagtagtg 1620

ggaacaggca gtactgttga gaggagagca gtgtgagagt ttttctgtag aagcagaact 1680

gtcagcttgt gccttgaggc ttccagaacg tgtcagatgg agaagtccaa gtttccatgc 1740

ttcaggcaac ttagctgtgt acagaagcaa tccagtgtgg taataaaaag caaggattgc 1800

ctgtataatt tattataaaa taaaagggat tttaacaacc aacaattccc aacacctcaa 1860

aagcttgttg cattttttgg tatttgaggt ttttatctga aggttaaagg gcaagtgttt 1920

ggtatagaag agcagtatgt gttaagaaaa gaaaaatatt ggttcgcgta gagtgcaaat 1980

tagaactaga aagttttata cgattatcat tttgagatgt gttaaagtag gttttcactg 2040

taaaatgtat tagtgtttct gcattgccat agggcctggt taaaactttc tcttaggttt 2100

caggaagact gtcacataca gtaagctttt ttccttctga cttataatag aaaatgtttt 2160

gaaagtaaaa aaaaaaaaat ctaatttgga aatttgactt gttagtttct gtgtttgaaa 2220

tcatggttct agaaatgtag aaattgtgta tatcagatac tcatctaggc tgtgtgaacc 2280

agcccaagat gaccaacatc cccacacctc tacatctctg tcccctgtat ctcttccttt 2340

ctaccactaa agtgttccct gctaccatcc tggcttgtcc acatggtgct ctccatcttc 2400

ctccacatca tggaccacag gtgtgcctgt ctaggcctgg ccaccactcc caacttgacc 2460

tagccacatt catctagaga tggttcctga tgctgggcac agactgtgct catggcaccc 2520

attagaaatg cctctagcat ctttgtatgc atcttgattt ttaaaccaag tcattgtaca 2580

gagcattcag ttttggctgt ggtaccaaga gaaaaactaa tcaagaatat aaaccacatt 2640

ccaggctgct gttttctctc catctacagg ccacactttt actgtatttc ttcatacttg 2700

aaattcattc tgctattttc atatcagggt acagacttat aagggtgcat gttccttaaa 2760

ggtgcataat tattcttatt ccgtttgctt atattgctac agaatgctct gttttggtgc 2820

tttgagttct gcagacccaa gaagcagtgt ggaaattcac tgcctgggac acagtcttat 2880

aagaatgttg gcaggtgact ttgtatcaga tgttgcttct cttttctctg tacacagatt 2940

gagagttacc acagtggcct gtcgggtcca ccctgtgggt gcagcacagc tctctgaaag 3000

caagaacctt cctacctatt ctaacgtttt tgccctctaa gaaaaatggc ctcaggtatg 3060

gtatagacat agcaagaggg gaagggctgt ctcactctag caaccatccc tccattacac 3120

acagaaagcc ctcttgaagc aaaagaagaa gaaagaaaga aagcttatct ctaaggctac 3180

tgtcttcaga atgctctgag ctgaatgctc ttgctccttt cccaagaggc agatgaaaat 3240

atagccattt tatctatacc cttcctatct gaggaggaga atagaaaagt agggtaaata 3300

tgtaacgtaa aatatgtcat tcaaggacca ccaaaacttt aagtacccta tcattaaaaa 3360

tctggtttta aaagtagctc aagtaaggga tgctttgtga cccagggttt ctgaagtcag 3420

atagccattc ttacctgccc cttactctga cttattggga aagggagaac tgcagtggtg 3480

tttctgttgc agtggcaaag gtaacatgtc agaaaattca gagggttgca taccaataat 3540

cctttggaaa ctggatgtct tactgggtgc tagaatgaaa atgtaggtat ttattgtcag 3600

atgatgaagt tcattgtttt tttcaaaatt ggtgttgaaa tatcactgtc caatgtgttc 3660

acttatgtga aagctaaatt gaatgaggca aaaagagcaa atagtttgta tatttgtaat 3720

accttttgta tttcttacaa taaaaatatt ggtagcaaat aaaaataata aaaacaataa 3780

ctttaaactg ctttctggag atgaattact ctcctggcta ttttcttttt tactttaatg 3840

taaaatgagt ataactgtag tgagtaaaat tcattaaatt ccaagtttta gcaaaa 3896

12

ctttccgaag cctctaggtc attgtggtgc cttgtagctg tcccgggagc cctcagcagc 60

agttggagct ggtgcacagg aaggatgagg aagaccaggc tctgggggct gctgtggatg 120

ctctttgtct cagaactccg agctgcaact aaattaactg aggaaaagta tgaactgaaa 180

gaggggcaga ccctggatgt gaaatgtgac tacacgctag agaagtttgc cagcagccag 240

aaagcttggc agataataag ggacggagag atgcccaaga ccctggcatg cacagagagg 300

ccttcaaaga attcccatcc agtccaagtg gggaggatca tactagaaga ctaccatgat 360

catggtttac tgcgcgtccg aatggtcaac cttcaagtgg aagattctgg actgtatcag 420

tgtgtgatct accagcctcc caaggagcct cacatgctgt tcgatcgcat ccgcttggtg 480

gtgaccaagg gtttttcagg gacccctggc tccaatgaga attctaccca gaatgtgtat 540

aagattcctc ctaccaccac taaggccttg tgcccactct ataccagccc cagaactgtg 600

acccaagctc cacccaagtc aactgccgat gtctccactc ctgactctga aatcaacctt 660

acaaatgtga cagatatcat cagggttccg gtgttcaaca ttgtcattct cctggctggt 720

ggattcctga gtaagagcct ggtcttctct gtcctgtttg ctgtcacgct gaggtcattt 780

gtaccctagg cccacgaacc cacgagaatg tcctctgact tccagccaca tccatctggc 840

agttgtgcca agggaggagg gaggaggtaa aaggcaggga gttaataaca tgaattaaat 900

ctgtaatcac cagctatttc taaagtc 927

13

cactgatccc gcctggggcc ggctgagtgg cacttaagcg ggccatgcca tgcaaccttg 60

ggcgctgcca accgtgggcg agctctgggt gtgcgggcgg cctggcgcgg cgcttccggt 120

aaggcgtgtg tgcggcaggg cggggacaga accgtcctct cgggctctgg gcgtgtccga 180

gaccgcgctc cccgccgaaa tcaagctccg agtcatccgt gtggggcatt cgtcccccct 240

ggcacagttg gcctctttcc agaagcccgt tttgtttgtt ttacgtctaa attcgcgtcg 300

gttcttattt ctctccctgg caaggtctga agacgggtag gagaataacg tatgtagagc 360

tgtgtcagcg tgttatgatg ccgtcccgta ccaacctggc tactggaatc cccagtagta 420

aagtgaaata ttcaaggctc tccagcacag acgatggcta cattgacctt cagtttaaga 480

aaacccctcc taagatccct tataaggcca tcgcacttgc cactgtgctg tttttgattg 540

gcgcctttct cattattata ggctccctcc tgctgtcagg ctacatcagc aaagggccac 600

cagggggcag accgggccgt tccagtgctg atcattggca ttctggtgtt cctacccgga 660

ttttaccacc tgcgcatcgc ttactatgca tccaaaggct accgtggtta ctcctatgat 720

gacattccag actttgatga ctagcaccca ccccatagct gaggaggagt cacagtggaa 780

ctgtcccagc tttaagatat ctagcagaaa ctatagctga ggactaagga attctgcagc 840

ttgcagatgt ttaagaaaat aatggccaga ttttttgggt ccttcccaaa gatgttaagt 900

gaacctacag ttagctaatt aggacaagct ctatttttca tccctgggcc ctgacaagtt 960

tttccacagg aatatgtatc atggaagaat agaggttatt ctgtaatgga aaagtgttgc 1020

ctgccaccac cctctgtaga gctgagcatt tcttttaaat agtcttcatt gccaatttgt 1080

tcttgtagca aatggaacaa tgtggtatgg ctaatttctt attattaagt aatttatttt 1140

aaaaatatct gagtatatta tcctgtacac ttatccctac cttcatgttc cagtggaaga 1200

ccttagtaaa atcaaagatc agtgagttca tctgtaatat tttttttact tgctttctta 1260

ctgacagcaa ccaggaattt ttttatcctg cagagcaagt tttcaaaatg taaatacttc 1320

ctctgtttaa cagtccttgg accattctga tccagttcac cagtaggttg gacagcatat 1380

aatttgcatc attttgtccc ttgtaaatca agatgttctg cagattattc ctttaacggc 1440

cggacttttg gctgtttcct aatgaaacat gtagtggtta ttatttagag tttatagccg 1500

tattgctagc accttgtagt atgtcatcat tctgctcatg attccaagga tcagcctgga 1560

tgcctagagg actagatcac cttagtttga ttctattttt tagcttgcaa aaagtgactt 1620

atattccaaa gaaattaaaa tgttgaaatc caaatcctag aaataaaatg agttaacttc 1680

aaacatttca gaaaacaaaa aaaaagg 1707

14

ctcagccaga agaggtaatg taatgctgta gatgggaata ggagcattga tcttgctctt 60

cttcctgact gtagtacttc ctttctatgg ctttaaccag ccacctcctc cctgggaaac 120

atctcctgtg ggcttgttgg gtatagaagc tactctaaga cccaaccaga taccatgatg 180

ccactgttaa ttctgtttgc tcttctaatt aacctaagct agtgtgtatg tggacaggga 240

gggtggacaa aattctacag taaatatttc aaaaattata gcatcataga atcatcttta 300

tggctgccag atttgtcatc aacaccccca ggatagacag tttcatcttc cgacctatct 360

ggaaaatctc aaggaccatg tccccagacc tcctaactaa ccatagcacc ccaaaatacc 420

caaaccccta ttgtgaagtg gaactcttcc ccacttagtg gntcccccct ggaccctgct 480

gtccccctgc cctgaccact attatcggaa tctgggaagt tgggcatcta tatctccagt 540

gcactcataa ctctaacatt tgcatcca 568

15

attattttaa aagtaggtca catacatggt tgaaaacaat caactggtaa aaaagatatt 60

ggatagaaag gtaagtctgt gttctacttg agtctgagac atatgccctg aagagtttct 120

tctttatctc taagtatgtc cgaggcatga ataactgtct gacatataca catctctaca 180

cagacatttc tcagcttaat ttttctttac ctcagcaatt gttccatatc agcacacata 240

caaaatactt ttacactgct acatttcatc aggaggatgt actaccattt atatgcccag 300

ttcccaagaa taaacagttg ggtcattacc atgcctttgc taaaaactgc tgaaacagac 360

tttgcatcca cagtctgcac acgtgaacat gtttctagat gtggagttgg gggccaaaga 420

gtaaatggat tttcatcttt gacagatttg ccctccaaaa aagacaacac tagtttccat 480

tcccaacaaa actccgtgag cttacctgac agcctttggt aaacagtatc tatgtatatt 540

aaactcctga tctcagttgc tggcacaggt gaaaaatact atctctaggt ggttatttgc 600

atctgtgact gagactgggt ctctttttaa atccacacat ggccatttct atatttattt 660

cctacgggtg tcactgtgtt ttgcacatta ttctatttct cagggtcttg gcattcttct 720

tactgatttc taaaagtaca cactcaatgt taaagaattt atcctttgtt atgtgtgttg 780

caaatatgtc ctccctccct ggtcctctgt ctctggaact caaatgaagt aattgttttt 840

gccacacaga ttattttgta taatttttgt gtagtcagtg gtcaaacaga ccattcttta 900

ccatttctaa gttttgtgtc ttgcttagca agatcctttc cccttcaaaa ttatcattct 960

ttcaaa 966

16

gtcaagctct acctgagcga caaccacctc aatagcctgc ctccggagct ggggcagcta 60

cagaacctgc agattctggc cttggatttc aacaacttca aggctctgcc ccaggtggtg 120

tgcaccttga aacagctctg catcctctac ctgggcaaca acaaactctg cgacctcccc 180

agtgagctga gcctgctcca gaacctcagg accctgtgga tcgaggccaa ctgcctcacc 240

cagctgccgg atgtggtctg tgagctgagt ctccttaaga ctctgcatgc cggctccaac 300

gccctgcgtt tgctgccagg ccagctccgg cgcctccagg agctgaggac catctggctc 360

tcgggcaacg gctaactgac tttcccactg tgctgcttca catgcccttc ctggaggtga 420

ttgatgtgga ctggaacagc atccgttact tccccagcct ggcgcacctg tcaagtctga 480

agctggtcat ctatgaccac aatccttgca ggaacgcacc caaggtggcc aaaggtgtgc 540

gccgtgtggg gagatgggca gaggagacgc cagagcccga ccctagaaaa gccaggcgct 600

atgcgttggt cagagaggaa agccaggagc tacaggcacc agtccctcta cttcctccta 660

ccaactcctg aggagcttca gttgcaagtc aatggccaag gacccaactg cagcatgttc 720

tggaagcctc tccattggag tggaaaggat ggctctgggt catttgggag tggctctgct 780

aagtagagac tgatggagaa agccaggtgg aatgccataa aatcacactg agaaaatatt 840

tc 842

17

ctcaaagatc cacgtggccc tgggtggcag cctgttcctc ctgaatctgg ccttcttggt 60

caatgtgggg agtggctcaa aggggtctga tgctgcctgc tgggcccggg gggctgtctt 120

ccactacttc ctgctctgtg ccttcacctg gatgggcctt gaagccttcc acctctacct 180

gctcgctgtc agggtcttca acacctactt cgggcactac ttcctgaagc tgagcctggt 240

gggctggggc ctgcccgccc tgatggtcat cggcactggg agtgccaaca gctacggcct 300

ctacaccatc cgtgataggg agaaccgcac ctctctggag ctatgctggt tccgtgaagg 360

gacaaccatg tacgccctct atatcaccgt ccacggctac ttcctcatca ccttcctctt 420

tggcatggtg gtcctggccc tggtggtctg gaagatcttc accctgtccc gtgctacagc 480

ggtcaaggag cgggggaaga accggaagaa ggtgctcacc ctgctgggcc tctcgagcct 540

ggtgggtgtg acatgggggt tggccatctt caccccgttg ggcctctcca ccgtctacat 600

ctttgcactt ttcaactcct tgcaaggtgt cttcatctgc tgctggttca ccatccttta 660

cctcccaagt cagagcacca cagtctcctc ctctactgca agattggacc aggcccactc 720

cgcatctcaa gaataggaag gcacggccct gccaatatgg actcagnnnn nnnnnnnnnn 780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840

nnnnnngggg agggagagga tgggaccagg ttggaccacg tggcatcaga ggtcccatcc 900

agatccaact ataggtccaa gagtccacgt aagcaggttt gcaaggctct aaagttccta 960

tagtcctgag accccctgcc agcaaagagt gacagtcacc tccatgccct gccctcattg 1020

caaagccctc actcaccttc tggtctcagc aagggaggag agtctgttgc tggcatagcc 1080

ctggaaggag cccccagcct ctcccctcct cctccttgtc actggcctcc cacaactccc 1140

cttctggctg cctgtaacct tgaggggcat tcaggaggcc agcgttccct caggcactgg 1200

gggtttgttt tggggggtgg gagttgatcc tcccacccag tctgcccctg gtctctgccc 1260

atccaatcag agcccaccct cctggaagag acccccgtgt tcagagtgct ggcagccctg 1320

cacgtgtcca gggacactgc atttcaaaga accactgagt gggtgagcta ccttgggcaa 1380

accccccact cctgactctg actgccacgt gggtggcccg acctctgacc tgctgtcatc 1440

gtagaggtag aaagcaaaca atctggggct cagcacacct gggggtgctc ccactcattc 1500

agtgtgtggg gcccctgagc agaggctggg cattgccact aggacctgag ctcctagaga 1560

acaaggacct gggtggcctc gcttactgtt ccagcccagg ccaagcacag ggtctggctc 1620

gtggcaaacc ttgaataaat atttgttggc t 1651

18

gccacccacc ccacgtgcca acntcccctc cccgtgccag cnctgccgct tccacctggg 60

ccacccaccg gaccctcgca cgccgtgcca ggcctgcccc agacgcgtct gcaggccgct 120

tgccctcctg tnccctcccc gcaggggcaa cagtggagac gcaggggctc tgggcccgta 180

ccgccaactc gggtcacacc tgaacgctgc tgccagccga tgccccagcc ctgcacgcca 240

cccactatcc cggcacgctc cctctgcaga tggtcgccgc acctacaagc cctggccgca 300

cccaacctgt gttgttgccg cccggccctt ncctccacag ntctncttcc tnccgcccgg 360

cacttctgtg gaccccttct tagttcacag gcacggntgg ggccggtctg tgctggcgnc 420

tgctggccac tgagggacag ggacacgtgc cacctgctca tctctgccct gaggtcaccc 480

cgtggtccct ccacgtgccc atctctctgc agtgccctcc tcgcctgtgc agcccgccca 540

cccacaggct cacccctcct gccggctgcc agaggccccc tccagcaggg cctctctccg 600

tngccccagc ttcactctct ccctcagcac ctgccctgct ggaggcccca gccctccgtg 660

gacagcaggg gccacgtgga gcccgggccg ctcacccgcc acccagtgct ggccgccttc 720

ttggtgccaa acccccttcc cccacccaga gactgggcag ctgtgtctgg ttcgttcttt 780

gcactaacca catttgtcat ctctagggca ggctggggct gcgggctgag ggggaccgct 840

ggcacccccc ttccctccct tcttggttcc atttccatcc atgacaggta cagcatccca 900

ggagcccggc ctgaggggct ggacccgagc cggctgtgaa catccctcag cccctgctgt 960

ccccccttgg gactaaccac taacctcacc cccaaactcc acgggtgccc ctagctggcc 1020

cagagccggc agtgtgagcc caagtccggg ctggagccga ggccggagca gctgtctggg 1080

agtcaaggct gcagtagcgt ttcttcatgg ggtgctccag ggggtgccac agaccgacag 1140

gcagcccaag ggcctggaca cccctcccca ggcaggtgct gccccaggag gactgtcctc 1200

gggaatgaac ctcccgcggg ctttggactg aggtccctgt ggcctcggtc tcctccccat 1260

gaagtgggag cgaggctccc caatggtgct tttggcttta gtgtacgatg tttgctgtgc 1320

ttcccgccgt ggagggcaga gccaccccac atcaggatcg gacgtgctac ccctcccggt 1380

cccggccctg gcccagccag cccagccctc gaggctcgat gcctgtgcca aggccagggg 1440

cagccagagg gcagctggat ggccacgtgc aggggtcaag gctgggccct gcagtggggc 1500

gggccgccag ccccagcagt ttacagacgc atggctcttc ctcccagagc agccggcagc 1560

tacctggacc ggaaatgtcc tcatccccct ccctggggcc aggctctgcc ctggccttcc 1620

tctgtgaacc cctcctttct ttgtgctggt gtctgggacc aaaaaggggg aatatgggag 1680

ggcagagtgg ggaggggagt ccatgggcct ggggccccaa gccggggcgt ctgagctccc 1740

caggcatgac caaacctcag tggaggggcc tctgcttcag gccccgcctg gctgacattc 1800

tgagcccccc tcggaggccc cgccacagcc aacctgccca gtctttcctc tggggcttga 1860

cccgccaggg gagttctcca ggcctagggc caggagagag gccctggcac cctggcgtgg 1920

gtgcccgcca aacgccctgc gaccgctaca gaagcacaaa tgctgtccat ggccgtgagg 1980

ctgcctgcca ggtgaatgga catagcgtga gaggcggtga ggccagggct tccagcctcg 2040

tgctgtctcg ggactcctga ccgtggtgtg cgtgtgtgcc cgtctgtgac tttctactca 2100

ccaaggttga agaaaggaaa cggggaaaat caaaaggggt tcaaacccca cctcagtagg 2160

tggaggggag cgcctgccat tggttgtatt tttgttctga gttttcggtg ccgtgttcct 2220

aactactcca tcccatgacc tcgccacacc tactggggca tctggctggt gcctgctgcc 2280

atggccagcc cccactctca ccctgcacag ggggtcttgc agcccccagg cccacagcct 2340

cgttgggagg acagggtggc cctggggaca agagggagga gcccaggggc ttacctcact 2400

gagagtgctc cccagcaggc atccactacc ccagggcccc ccacatgtca tggcaaggtt 2460

ggtagtgaat gggcctggtt gggagcagcc cctggcccat tgcccaccca cccatctcac 2520

tatgcaattc gagttccaag caacatttgc tcctgccctg gggccagctc tgccccagcc 2580

ctgagagggg tggtgaggca gccccctgga ccccagaacc ccagacaagg gggcaggcgg 2640

gggaccaggg cctctcctgt gggatctttg ttttgtgttt aaccataatg gttgtgtact 2700

gaaccacttc atatttgtta tatataatat atatatatat aatctcctta agactcagcc 2760

tcctggttta cccccccggc ctgggcatct gacctccccc accccagtgt gatttaacat 2820

ccaggaactg aggcctgaac cattttgcat ttccccctcc tccagcctct gtagggccat 2880

ggctgtatgt actgtcgctg tgtttttttg tttttttaga actgggtttg ggggctgatt 2940

tttatttctt tgggggcttt ttttcttggc aaatactaaa aatctcgtca atgtaatttc 3000

tgtggtttct attcagcttg ggtttcatgt tttaaaataa attttaaaaa gcaaaaaaa 3059

19

cctacacgcc actgtggttt gagaagaggc tggatccgct gaccggggag atggcctgtg 60

tgtacaaggg cggctactgg gaggccaagg agaagcaaga ctggcatatg tgccccaaca 120

tcttctgagc gccacccttg caacaaatac aggcgcctgc acagcctggc ccacctgttc 180

attaatgcac tcaatttagt actgaatggt ctttctccca gcccattccc agcccttcct 240

atttcctttc ctattttttt tttctcccca cactttcttg ggactcccac cttggaagga 300

ggaagggctg acctgggttc tctccagccc ccaggtgcgc cgggtcaccc gtgccccttc 360

attatggacc tgggccctac cggaacccct gccccagtta ccacaactca ggccggctgg 420

cccgggccat gggctgcgca aatcaccagc ccccaaccca gggaggaact ggcccctcct 480

agggagcctc ttcgactttt ttagaaaaat gatctccatt tctttccagc catgatgttt 540

agtaaatatt tttagtaccg cacttagcag acagctttcc aagtgtgctt tcttgccaca 600

aaagtgtcct ggcaagagcc ccttattttt aagacatcag gaagccagac cgctttgagt 660

tgggagaatt ttgtagctca acatatcaag tcctcgatgg tatctgagct gcccacaccc 720

ccacctgcca aggccccaca gagcccaaaa cagaaggggg ctgccccagc ccagcagagc 780

acagagtttc tggagctccc atccacagat gcaggagggg gtactgatgg taacccccat 840

gtggatttga gggcagcagt ccctggcctc accctagcca gcctgggtgg ctccctagcc 900

ccaagaggcc aggaagggct ggaaggcagg gcctgcaggt gctccccgcc ctgagaccca 960

ggccccaaat cagcaataat gaacaaaccc ttggcccagc ctgggctggt gacctgggca 1020

ccagagacct tgcatccctc ctcatcctag gaggccccta ggggtgcccc atctcagtgt 1080

cccctgaact ctttatttgc ctaatttata tatatatata tgagatatat aaatatatat 1140

aaaatagcta ttttgcttaa atttctacag tatgtaaaag tgaaaaaatg atgaagacgg 1200

gtgcacctgt ctgagtttgg ccctcatgtg agctgtgccc ttccctctcc tcatgccccc 1260

ttccagcggc ttctgccaac catggggggc tggaccacca tggccactga cccagcccct 1320

cagaatccca cactccaatc ctttccattt cagtttagtc ctaaaagttc atcacagggt 1380

ctttctttct actccaggac tggttttgtt tttatatata taaaaaaaaa aagtgaaaac 1440

accaatgtgt gaaatgcctt acaatgccca ctggagaggc ggggcggggt ggggcaggat 1500

ggccccacta gggctcctac agagctgtgg aatgtacctc tccccaacac tgttttgtta 1560

gcgagcacct tttgaccagt aataaaaaac cttggctttg gagttttcca aaaaaaaaaa 1620

aaanggg 1627

20

ggctcgggga ccactggtag cggcagcagc tcgcgcccgc gccctcctcg tacccgtgcg 60

cccccggaga ccgatcccgc cccgcggccc aggccgggcc tgaacccagc gggtgccgct 120

tctccacccg aggcttccac ctccaacgag ccatgttcca ggctgcagga gccgcccagg 180

ccaccccctc tcatgacgcc aaaggcggcg ggcagcagca cggtgcagcg ctccaagtcc 240

ttcagcctgc gggcccaggt gaaggagacc tgcgccgcct gccagaagac cgtgtacccc 300

atggagcggc tggtggccga caagctcatt ttccacaact cttgcttctg ctgcaagcac 360

tgtcacacca agctcagcct gggcagctac gccgcgctgc acggggagtt ctactgcaaa 420

ccccacttcc agcagctgtt taagagcaaa ggcaactacg acgaggggtt tggccgcaag 480

cagcacaagg agctctgggc ccacaaggag gtggaccccg gcaccaagac ggcctgaggc 540

ctctgtaacc ttccaccccc tctgcggaag gcctggagcc ggcaggggga aggtgggaag 600

gaggtcgagc tgggcttgcg tgggggccag gtgggaaggg gatgaggctt gctcaggcgt 660

aggggaccag ggcagggctc tgctccagga ctccttcctt cttccttctc ccgcagccgg 720

tgagggtttg gaaaccagga ttggggtctg cccaccaccc tgcttcctgc ttcgttcagc 780

ctccctcccc acctcacccc aggaccccct gggaggcccc caagcccagc tcccctatct 840

aggtgccttt tctccagcaa ggagtcagca tgcccccctc agggtcccaa gctccctcac 900

tgccaccgga gactgtgtgg cccccacgtc tccccatcta cctctaccct taacctgttt 960

ctgagccacg gagacaggga ggaaggagcg cgacagtgcc acctgttggg catcataaat 1020

gcccctgcag cccatggggg aggagatggg gaagtggagc caccctgcct ctgcagggca 1080

aggcagggcc tgccccagtg gggcttggga ccatctcgaa ccaccagcgt ggagaagcag 1140

aagcaaaagc actcgccagg ctgcagcctc aggcactggc aggggctggt gcggccccac 1200

tcccctcccc cgctcccatt tgtgcccatc ctgttgtgac caaccccgtt ttaaacatgt 1260

ttcaatagat cccgccccgc ggcccaggcc gggcctgaac ccagcgggtg ccgcttctcc 1320

acccgaggct tccacctcca acgagccatg ttccaggctg caggagccgc ccaggccacc 1380

ccctctcatg acgccaaagg cgcgcggcag cagcacggtg cagcgctcca agtccttcag 1440

cctgcgggcc caggtgaagg agacctgcgc cgcctgccag aagaccgtgt accccatgga 1500

gcggctggtg gccggacaag ctcattttcc acaactcttg cttctgctgc aagnactgtc 1560

acaccaagct tcagcctggg nagctacgcc gcgctgcacg gggaattcta ctgcaaaccc 1620

caanttccaa gcagctgt 1638

21

gagaacattg gcttatgcca gataccacac cacatctggg cttacattct tgtatctttt 60

ttggtgtgtg ggcggggggg gtggggggca gttcagtgaa gtctagaaga cctgctggac 120

aaattctaaa agagctagag ctgtaacact tattcttgca tcttattaat tttctatgat 180

attttttcct tcttcgtagg gacttgggac aatctggctt tgctgctttc taactgctag 240

gcacctctct ctaaccctca ttgtcagagg gaattggagg atatccacag tctgttcctg 300

ttctgatatt ctgagcagag aaaaggcact aacggttcct cttagctatt taattatcag 360

aagcaagtaa tctttcccca gataatattt tgccctagaa gaagccgtga tttagctctt 420

ttattgtgct tacttggtcc aaatacatct gtggggtgtt ttgtcatttc ttaatgaatg 480

aatcatagtt ataaccaggg gccaagctgc ccaagaggct cttcagagat catggatgct 540

ctctttctgg aagctgtggc ctgatggagc agccccattc cagggtccca tctgtccgga 600

gttgtgtatg tcaagtccgg ctcagtcttt atttccaaca ctagccgtgg tcctgtgcag 660

tcaagctctc agctagtgtt tagggctgtc tgtcagaaat ggttatacgt gggcaaaaga 720

agatctgaca gctcctatat accttatctt actgaattct taaactttga accagttctt 780

ccacttactg acttgttacc actgctgact ttctgaaaag ttttccagtt tttgtttttt 840

gttttttgtt ttccagtagg ggattagaat gtttagtcct acttagtaag aaaaatattg 900

tatttttaat cattcatagt gctggt 926

22

ccagaatgat tgcctctact gtcctcattg acttgtttga accttagtgc cttaccctgt 60

cctcttccca gttctcttta tagaagctct aggagctttc gaaaagccaa agtctttctg 120

aagaatctgt gctggacaga cataattccc tttctcattg tctccatctt tgttggtcat 180

ggtaaggttt ttccatcagc ctctgaaaaa atagttgtgc acaacatctg ctcactggac 240

tgtctgatcc aatgtaattg gctgcgtctg gctaattcta agcactaaag tctacatcta 300

agctatagat ttaagcttga agctacagat tatatcacta tcaccaccac ccctcaccct 360

atgnnnnnnn nnnnnnnnnn ntcttaagtt aaagatattt gttgtctttg aatgatttgc 420

tgtcacagac tatttggtag aagaaatatt tttcacctga gagaggaaga gaaatttctc 480

tagtaacaca aagagtgagt tctaaaaggc atgcccacat ctctttcgtg ccttaaggat 540

agtgagatgc acacttatat atatactgta tnnnnnnnnn nnnnnnnnnn nnnnnnncat 600

atatatatat aatattgcaa gcttaagttt gcaatttccc aaacaataca aaaagcaaat 660

tacacaccct caccactgtt cttatctcta tagtgatgaa acattaatta gggatcttgc 720

tgcttttctt tttctacacg aagttttcat taaagccaca gaataattga tagggcagct 780

gtttgagaac aggtcccatt ttcacattag ggctttaaat gaattagaaa ctatttgagg 840

ctataaaaat gtccttgagt ttggagcctg agctctggtg aaatgctgat acatctgatc 900

tatcatggga attgcagtta gagagagtaa ggaataccat ttagtcatct atccgttctt 960

cacttagcag gaatatgaaa gaaaggcaca tgtttaagag gaatacctaa aggtttttct 1020

aaattccaac atttaaaagg caattgtggg ctatttttat tttttaatat tttgaaataa 1080

agtttagtgt ctagggctgg gagccaggac tgatcttcca tttctttttc tttgttccca 1140

gccatgcttt tgtaacttgc caggtggact tgaccaacta cattaccatg nnnnnnnnnn 1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntaccta cctcacaggg gtgttgtgag 1260

gctctattca tttgctcctt tattctttcc tgtattctct gtatgtccag cactttgtag 1320

ccatgggagg aaagggacta taaaagtgta caatgttaat ggaatgatac ggtacctgaa 1380

agccttgttt tctagtaaga aaatgctacc ttgctgtaca tacttataac cttgtatttg 1440

gaaatgagaa ataggtttat attttcagat ctctcaaaaa tcacatcatt tgaccaaaga 1500

ataatttaag acacatagaa cagatttttt taatttatat tttcatcctg accagcttag 1560

ttctaataat ttttagttgt gagtgattaa aaaactttgg atcaattttg gtcaaacatg 1620

ccaactttgt agtctgagtg acaggcaagg atttttgggt ttaagatgca cttttagcac 1680

acatttgtat ttcccttggc atatcagatt gagctaatgg tgatgttatt tcaatctaac 1740

agccaccaat ctgaaattgt atttcaaatg ttgattctgt agttctttaa ataataatga 1800

agctcatctt atacattttg ctttcaccaa ttgattcctt cttcttttag cccactatta 1860

aaacatttct tactgaatgg ttcatgtagg cttgctgaac agcacgcatt acttgcttcc 1920

tgaagagttc ccccattcat ccatttgtcc cattagttgc tgtggattat caagttttga 1980

aggaactgta catcccaaca gactgaaaca ttctaagtga aatgagtata atccaagtaa 2040

ctggtgaact ttggaggttt ggagcttgaa gagaatggct aagaagattt gaattatagg 2100

gagggaacag aaatcataca tgaaaaggtt ttactgagaa ggggaaaacc ttagatagag 2160

ggacatgtga aacaaaattc atttgaaatt ttgattcaga catccatttc cagtggcaaa 2220

cagcaaagcc tgaacccata aacccaaatg ataggtgaag ttgggtggtt ttatccaatg 2280

tctcaagcaa gcaatgtctg ggaatatcat agagtaacaa gtgctggtca gccaaagaaa 2340

cattcactgc tggtgaacca ataccataag catgtattat ctaagcactt gatcaagaaa 2400

tatacatgtt gtacaagctc tcaattttgt tcatttatta tcaaattttt aaaatacaag 2460

tttggtatgt gatttggaaa agatgccttc tggatcttaa gccagttgtc agtggaggtc 2520

ctcagggctg caaatgtcaa gacataaccc tgttcctcac catcatgata ccagatacag 2580

gtgaatacat aggaactatc tgcctgtgtc ctcaatctcc cttcaaacaa gatgctgatt 2640

tgtagggtac ttggcaggtt aaattaaacc agaagaggtg acttaataaa aaagggaatg 2700

acatttaggg tataaagatc tcataagaaa tgtaatatgt aaattatatc ttgctttatg 2760

ttgtaaaata tacattgttt gcgctagaat agaaatgatt tcttttcaat aaaaagaaag 2820

aaggactcta ccatgtcttt tgttata 2847

23

ccttgatgng ctggcggcct cggccgggaa ctccggggta gatgaccgtg gacagcagca 60

tgancagtgg gtactgcagc ctggacgagg aactggaaga ctgcttcttc actgctaaga 120

ctaccttttt cagaaatgcg cagagcaaac atctttcaaa gaatgtctgt aaacctgtgg 180

aggagacaca gcgcccgccc acactggcag gagatcaagc agaagatcga cagctacaac 240

acgcgagaga agaactgcct gggcatgaaa ctgagtgaag acggcaccta cacgggtttc 300

atcaaagtgc atctgaaact ccggcggcct gtgacggtgc ctgctgggat ccggccccag 360

tccatctatg atgccatcaa ggaggtgaac ctggcggcta ccacggacaa gcggacatcc 420

ttctacctgc ccctagatgc catcaagcag ctgcacatca gcagcaccac caccgtcagt 480

gaggtcatcc aggggctgct caagaagttc atggttgtgg acaatcccca gaagtttgca 540

ctttttaagc ggatacacaa ggacggacaa gtgggatgcc ttctccatcc ctgaacttca 600

gaacttccta acaatcctgg aaaaagagga gcaggacaaa atccaacaag tgcaaaagaa 660

gtatgacaag tttaggcaga aactggagga ggccttaaga gaatcccagg gcaaacctgg 720

gtaaccggtc ctgcttcctc tcctcctggt gcattcagat ttatttgtat tattaattat 780

tattttgcaa cagacacttt ttctcaggac atctctggca ggtgcatttg tgcctgccca 840

gcagttccag ctgtggcaaa agtctcttcc atggacaagt gtttgcacga gggttcagct 900

gtgcccgccc ccaggctgtg ccccaccaca gattctgcca aggatcagaa ctcatgtgaa 960

acaaacagct gacgtcctct ctcgatctgc aagcctttca ccaaccaaat agttgcctct 1020

ctcgtcacca aactggaacc tcacaccagc cggcaaagga aggaagaaag gttttagagc 1080

tgtgtgttct ttctctggct ttgattcttc tttgagttct cttacttgcc acgtacagga 1140

ccattattta tgagtgaaaa gttgtagcac attccttttg caggtctgag ctaagcccct 1200

gaaagcaggg taatgctcat aaaaggactg ttcccgcggc cccaaggtgc ctgttgttca 1260

cacttaaggg aagtttataa agctactggc cccagatgct cagggtaagg agcaccaaag 1320

ctgaggctgg ctcagagatc tccagagaag ctgcagcctg ccctggccct ggctctggcc 1380

ctggcccaca ttgcacatgg aaacccaaag gcatatatct gcgtatgtgt ggtacttagt 1440

cacatctttg tcaacaaact gttcgttttt aagttacaaa tttgaattta atgttgtcat 1500

catcgtcatg tgtttcccca aagggaagcc agtcattgac catttaaaaa gtctcctgct 1560

aagtatggaa atcagacagt aagagaaagc caaaaagcaa tgcagagaaa ggtgtccaag 1620

ctgtcttcag ccttccccag ctaaagagca gaggagggcc tgggctactt gggttcccca 1680

tcggcctcca gcactgcctc cctcctccca ctgcgactct gggatctcca ggtgctgccc 1740

aaggagttgc cttgattaca gagaggggag cctccaattc ggccaacttg gagtcctttc 1800

tgttttgaag catgggccag acccggcact gcgctcggag agccggtggg cctggcctcc 1860

ccgtcgacct cagtgccttt ttgttttcag agagaaatag gagtagggcg agtttgcctg 1920

aagctctgct gctggcttct cctgccagga agtgaacaat ggcggcggtg tgggagacaa 1980

ggccaggaga gcccgcgttc agtatgggtt gagggtcaca gacctccctc ccatctgggt 2040

gcctgagttt tgactccaat cagtgatacc agaccacatt gacagggagg atcaaattcc 2100

tgacttacat ttgcactggc ttcttgttta ggctgaatcc taaaataaat tagtcaaaaa 2160

attccaacaa gtagccagga ctgcagagac actccagtgc agagggagaa ggacttgtaa 2220

ttttcaaagc agggctggtt ttccaaccca gcctctgaga aaccatttct ttgctatcct 2280

ctgccttccc aagtccctct tgggtcggtt caagcccaag cttgttcgtg tagcttcaga 2340

agttccctct ctgacccagg ctgagtccat actgcccctg atcccagaag gaatgctgac 2400

ccctcgtcgt atgaactgtg catagtctcc agagcttcaa aggcaacaca agctcgcaac 2460

tctaagattt ttttaaacca caaaaaccct ggttagccat ctcatgctca gccttatcac 2520

ttccctccct ttagaaactc tctccctgct gtatattaaa gggagcaggt ggagagtcat 2580

tttccttcgt cctgcatgtc tctaacatta atagaaggca tggctcctgc tgcaaccgct 2640

gtgaatgctg ctgagaacct ccctctatgg ggatggctat tttatttttg agaaggaaaa 2700

aaaaagtcat gtatatatac acataaaggc atatagctat atataaagag ataagggtgt 2760

ttatgaaatg agaaaattat tggacaattc agactttact aaagcacagt tagacccaag 2820

gcctatgctg aggtctaaac ctctgaaaaa agtatagtat cgagtacccg ttccctccca 2880

gaggtgggag taactgctgg tagtgccttc tttggttgtg ttgctcagtg tgtaagtgtt 2940

tgtttccagg atattttctt tttaaatgtc tttcttatat gggttttaaa aaaaagtaat 3000

aaaagcctgt tgcaaaaatg aaaaaaaaac 3030

24

atgaattgtg taaacttaga tccttctccc ttttgggccc aaaagaaccc ttgatttagt 60

tccagaatcc aaccagtttc tttgttaaaa gggtcctttt gaagcaatta agtgctggta 120

agaatatttc tctgttgttg ccaggttacc ttctgctttt aaattgccat cttgtaaagt 180

gtatgtggtt cttaagtgcc agggagatca gccttgccca tgaaggttgc atatgtgtgg 240

tatacagttt ttacctgaaa gcctgagctt tctcttattc ctaaagtggt ggcaaaagaa 300

tgaactgggt atgaccctgc ccccttactg ggcttggata ttgaggacca gacgctgcca 360

aatctaggac aagacagacc atcaaagcag acttttgtgg gctcctcttt ggggtgacca 420

ctgctttcaa agccatctgc caaggctctc cagggcagga cctgactggt ggggaatgag 480

tgttcagaag ccttgggaga ggccaaagag ccattctagc atgatctgag aaaaccttcc 540

tgcagaggcc agaaaccttg agcttaggtg cctggggacc agcttcgaca ttctctccag 600

tttctgattc taatttttgc cacgtgtcac aacttttcca gtctctgaga aggtcccagc 660

ctttctcaaa tattctgatt ttgaaaatat gtatccaaag tgggaggccc ctgtgacatt 720

ttgccaactt aaacgagaaa aagacccccc gcacccggca cactccccct tcctccagcc 780

ccgcttcagc cacatgctcc agctgctgcc cagtaaagcc ctgtgccttt ttttcccctg 840

aatactgccc aaagcatccc cttcccatct gcctctcagg agttggggac tttgctagga 900

gattttttaa gtgttcctta ctgggacaac gtggagccac gtttgcagga gctccatttg 960

tatccctgct ggtgttgact tctgtgtagg ggccagttca tgtccctgac tctcacctcc 1020

cattagataa atgaagccca cccccctttt ctagagtgat gagagtcaag aagaggggat 1080

gtatgaacgg ccaaattccc atgtgagagg aagatgacct gatccaccta gccttttctt 1140

ctggatctgt cctccctcac ccctttcacc tgagctgtcc acagtaggaa acataaagaa 1200

acaatgtccc ctacatatcc ccatgactac ataatccatc atcgtaggaa ataggaaagc 1260

aaatttgatt ttggttttgt aaaacgtaca tgcttcaata attctttttt tgtgtcttaa 1320

atactcatag gggaaaaaaa cagctcaccc aaggtgttag gtttcacata tatattcatc 1380

aactatttta gaagatttaa ttctatcaaa tcttgtatta cctcagatca ttttaaatag 1440

caagccaata acgagctttg aaggctattt taccattcct gttcacaaaa ggttctcatg 1500

gtgcctgaca ggttaccctt gagggcttgt gtctactttt taaaagtcaa tggttttttt 1560

tcttgtgttc tagtttccat aataggagag aaaatataga aatatatgca aaaattatag 1620

ttttctttag atcagaaact gatatttttg ggtcagccat atgtattttg tttaaaggat 1680

ttaaaataaa gtgccgtcat gtagccctgt ggaagggagc acataaccag ctgtttggca 1740

tgacaggtga cttagtatat ttgtaattgg ttttaaaacc aatacaccat actttctttc 1800

tgcaaacagc catctttata cttagggaag aaaaattgtt gggttctaga cttttttaat 1860

ataaattttg ttgatatgga attaggtaag tttaagtgtc tatgtgcata tgttttttat 1920

ataagttttt tctattcagt ttcactgatc caactggcag tgggtaaata tggcataagt 1980

taataacact tttccccaaa atggtgcttt ggatttgaaa agggtctgat ggggagaagg 2040

agaacgtatc atcctagctt cctctcttaa taaacctaga aaaacgggta gtaaactgtg 2100

gatagtcagg aaaacaccca gcaagggaca cagctgtcag gaaatgaatc ttccccccaa 2160

cccccaccat gcagatggat agacagaatc tttcctgact agtcattagg atcaggggcc 2220

tctgttggat ttgtgtttct tgaagaatag ctggcagagt ggtataaaag acacgaatat 2280

ctcctggtct ataaggatac tctgatttgg ggtttgcatt tttcatggtt tttatttcct 2340

gttccccctg gagttttcca ttagtgagtt tttgtgcaag gatcttattt gtgatgcctt 2400

ccctccccta gaaagatttt gtgcaatata ttaaatgggg acagaattct aaatggataa 2460

aacaatggct ggttctagcc ctgagtgaca gtcttaaggc tagatccttc ccatagtatc 2520

atctgtcctc tggaatgact ctcctgtccc taaaggggtt aagagagaga tcacctagaa 2580

atccctctgg acacttgtgg gttctttagg gtttgagttt cttcttcccc ttgagcttca 2640

gagaggagag ttggcatggt taaatctgaa tggttacctc actgctgaaa acccagaggg 2700

gcgtggcaca ctcgcttgtg tggaaaagcc tctaaatgca tcccttcctt tctttcctgc 2760

ttcctttgcc ttacaattga agcagcccgt ggtaccatca cagtatgcag agacttcctc 2820

acctttcata tctagggacc acccccgatg cattggtgag ggtgggcact tataaatgcc 2880

tgctattgtt aagccattcc agcctcttcc tctgaataga ccagacgccc tttcacttag 2940

ttcagtgcca gtccttttgc cttcccaacc ctgctgttag gcctgctgtt ccctttgctc 3000

ttgattagga gagatggaag gagatgagct cccataactg aattggcctt tggttcatgt 3060

tttctcccca tatgtatata tgccatatgt gaatatgcca tatatatgtg ccaacaaatc 3120

tatctacgtt gttcttttca aattagcacg cagataggaa ttttgagttt cttcttcttt 3180

tagtaactag tataacaagc actggtattt ttgtacaaaa aagaaaaaca aaagattgac 3240

tattgtggtc tgcatgacat aaacaaacaa atggtgatat caaagcaacg tataccccag 3300

tccagtgtgt gttgccataa tttgcaattc agcttaacag tgcacccaat ctatatttgc 3360

attttgatat tatttaagct ccatgtacaa ggttttgcat gtatttatat ggttcttagg 3420

gaaaaaaaat gctataaact gcaaatctga aattcaaatg tgttgttcca ctgagaccag 3480

aagaagaaga ggagttttaa aagggataat ttgttggagc caataaagct ttttgctgat 3540

gaacagaaac caatactgct gtgcactgag aataaaaact catgcccact tgtaaaa 3597

25

ggaaaaggaa ccacgaaaaa tgtggctata aactgttntc accttcaaga ttctngagag 60

ataactacac ataccctttg ccatagtggg aatgactgtg tagtagtnac tggaggagaa 120

agtttctttg tacacaacta tgctttgatt ttcaagagga ggaatgaaat tgcctcgtaa 180

aattacagag ttaaatacaa tgtacttaag agattatggc atcagaaacc cacaatgtta 240

aaaaacggaa cttttgtaat aagattgagg atcatttcat tgatcttcct agaaaaaaga 300

tctctaattt cactaataag aacatgaagg aggttaagaa atctccaaaa cagttggctg 360

cttacataaa tagaacagtt ggacaaactg tgaaaagccc agataaactt cgtaaagtga 420

tctatcgcag aaagaaagtt catcatccct ttccaaatcc ttgttacaga aaaaaacagt 480

cccctggaag tgggggctgt gacatggcaa ataaagaaaa tgaactggct tgtgcaggcc 540

acctgcctga aaaattacac catgatagtc gaacatattt ggttaactcc agtgattctg 600

gttcttcaca gacagaaagc ccatcatcaa aatatagtgg gtttttttct gaggtttctc 660

aggaccatga aacaatggcc caagttttgt tcagcaggaa tatgagattg aatgtagctt 720

taactttctg gagaaagaga agtataagtg aacttgtagc ttatttgttg aggatagaag 780

atcttggcgt tgtggtagat tgccttcctg tgctcaccaa ttgtttacag gaagaaaaac 840

aatatatctc acttggctgc tgtgttgact tgttgcctct agtaaagtca ctacttaaaa 900

gcaaatttga agaatatgtt atagttggtt taaactggct tcaagcagtc attaaaaggt 960

ggtggtcaga actatcatcc aaaacagaaa ttataaatga tggaaatatt caaattttaa 1020

aacaacaatt aagtggatta tgggaacagg aaaaccatct tactttggtt ccaggatata 1080

ctggtaatat agctaaggat gtagatgctt atttattaca gttacattga gagatttcat 1140

ctactaaaga gcatttggtt tttcaaaaca tccctgaact gtataattta caaaaaaaaa 1200

agtctcgtct gagaactgtg aactgtggaa gaaatcaaaa ctattttttc ttttaaaaag 1260

ccacgtaatg aaaccactaa tgaaatccca gcaatctgct tcacattgaa gtggaaaaat 1320

atccaaaagg agcagcttca atttcattga ggtgaaagtg cactatgaag attgttcacc 1380

tttgctgcat ttgggagtta tatggttatt tggtaacatt aagaactact ggattttaat 1440

gcaatcctgc ataaaaatat aatttatact atgtgaaaaa ataagacagg acttaccact 1500

aggaaccacc aagaccaatc atcattaact tttttaagat tgtgttttat taaaaaanaa 1560

aaacncttaa atgtgtgcag ctattttctt atgttgaaaa gactgaaagt ttaaaacatg 1620

aaaaaaatca atattaaaca ttttttgttc acactgagat actgtgtatg taaaatgcct 1680

taattattaa taagccaatg tgttatgata ccaatatctg ttttaaaaaa ctaaaaccaa 1740

ccatgcttct ggcatgataa aatcatggaa ttaaatcagg ggtttacatt cttgtagagt 1800

gttcttgaaa cactctctgc accattttta aaacttgaga atagttttag tatctctgat 1860

attttttgcc agaatcatca tgtcatgtat gaatgtgtta tccctatcta aggaaaaagg 1920

tgaatatgtt tttgtatgaa tgtttaactg gaaatgtcca tggacttggc taatttatat 1980

ttacttttta ttgtacatag atttctaata tttttcattc ctgtatcatt taaacttcct 2040

tcatttgagt aaattcacta aatatttcta ttttttgctt ttttaaattc tgattttata 2100

tgaattctaa ttctttttca ctacttatgt tttaaagagt tacatacagt gatttagaat 2160

ggtttacagt taatgctgat cttgtatttt aaattccaac actttgtgtc actacctcct 2220

ctaatggtta gtatgatatg ctagcagact gtatgaggtc tttttttaaa ataccacttt 2280

tagtggtcag tgaaccaaat tctggaatgt cttaacagct ctaaatctta cttgtcttga 2340

aaatgattgg ggtttaatac cactgctggt ggttcacaca tcatcccatc cttaatatgc 2400

ctgacaggca tctgagcaaa ggtttttagt aattgaattt ctctgcagta gtccttcaag 2460

cacttgaatg taaaccttta gcatttattc gtttaatgac tactgatacg aatctcaagc 2520

agatttcttg ctcttaaaag ttatgtttca ctgagttctg gttttgtgta gctatatttt 2580

atatagctag atattcctca cagtgaacat gaattgtaat aattggttat ttccttaagt 2640

ctttagatta taataatttc agattattgc acgtctgtga tttgagaggt gagttattta 2700

agaggccagt tttcaggaca tgggaatttg aattgtaaac ctgttatctc tgtgaaactt 2760

ttaacatgat aaaatataac ctttctttgt gcttaaaaaa aa 2802

26

gcataagcca ccatgtccaa ctgaaattct taataattaa taatttttga gcaagaggtc 60

cacactttca ttttgcactg ggttcccaaa caggtcctgg gtaggaagga tggctgagga 120

taaaacagga gttgctttgg cctggctgaa catttgaacc aatgatcaga gtttcatttt 180

atgattgtgt tactctgaac agatttgcta tttttttcca gctacattta gagttcctca 240

tgtatatatc acccctcttt ttccagtcca tctaacctct cctttttttt gtgcctagaa 300

tcagttctcc ttgccttcaa aatccctgat aagtgtccat ttctttttgt atcctttgat 360

gtagaagcca caagaatggc tttagcagct tattttaatc ttatgaatta ttcattcagg 420

attttttaaa tgattcagat gctttcagtc tgttaacagt atttataaaa catgtttcag 480

tgatacaaca taggtgaact aaaccaaaga tgcaaatgcc ttggaggaaa agaaattgta 540

ttatagagaa tcctgagata tatccttttg ggttgtttaa tttaaagcct atcacaaaac 600

aaagagaatt gtcgcacttt aattccaacc tcctgcagta cttcacaacc cttagcataa 660

gattctgaaa tttgtaatag gtggtaccta gtttgatgca gggttttgca gcagttgtgc 720

gaatgcctct gcgcaacggc ctttcagtca gactaaatga gaaaatccaa actgtcctat 780

caaaactgac ccacaataac tgtactctga ggcgaaacag agcaaatgtg ggtttcctgt 840

tttcattgta aaacattcca ggttctcaga ttgaagagct acattcagct gatagttgac 900

atctgttccc tcacacgtag tggctctcaa cacgggctgc actttggaat cacctgagga 960

cctttcggaa tcttcggttg aatcatcctg gctgtcctgg tgatgcttct tatgtgcagc 1020

taggctggag aaccactaca gggctgacac ctggaatggg agcttgtaac ttttacaaaa 1080

taatagatgt ttatcatctt ttgcaatttt tacttttaag tctatactaa aatgagccaa 1140

agaagtctta acaatgatgt atggcacaat tggttggttg aggctatcat tccatgatta 1200

caaataggtg gttatgtggg gtggttttgc acttgtggca attggactgc aatttggcct 1260

taaaatgaca caattcctcg ttctcagatg gagaggaatt gccttgaaat ttgcatgtac 1320

cagactaagt gccagtatat atatgactga tattttcgtg actcatagaa ggtgtccatg 1380

gtatagagtt tatgcctaca tctctatctt tattttgggc acacatgagc ttttgttaat 1440

tatttctttg tacttgttag aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngattt 1500

gtggtggatt caccttctta aaataataaa tttagaggat attaggaatg acattcaaaa 1560

caaatatagt gagaggtgat tttttaaaaa tttttgttcc tggtttccaa attatgttta 1620

ctttgatttg attatatgtt ggtatctccc aaatataggt taacttagct atttaaatgg 1680

tatcttttga catttaaaaa gaattaagta cctgtcaaat cttgcattga ggttgcagtt 1740

gaataagata aaagcttagg atgtcaaaaa ataatataga gaaatattat aagattttat 1800

gattattctt gaagtttttg atgcaaaagg aaaatatgct gaatagttct tccaaaaaat 1860

attatttccc tcaatatttt atttgtagcc atgtaattta aagagaacag aaaataactg 1920

caatcaaaag tatggtttaa tatcaatcaa agtggcacaa cagaattgat aagatcttta 1980

taacaatcaa ttggctgata ttaaaatatt gattttaatt gatcttttca attaaaatct 2040

ttagggcctg taactcataa aatcagcatc caccacaata tatggtcatt attggtttgt 2100

aagcatagat caccattgac tcctacctgg agagacatgt ctatttctaa aaatccagta 2160

gtttctttgc attctcagta gtacacgttg tatatatata tatgtaacaa atttggtagt 2220

tttcagtatg tgtgatgtcc tttgggggtt atttatcttg ctggtccata ggaggggtac 2280

actaccccaa gaatcaagac atctgagttc tagttctagt tctagctctg ccactgaaga 2340

gccaccttac ctggggcaag ttagccattg tctcccagtc atgtttacca cccatgaaag 2400

gactcgtcgg tttgatgttt ccattaagct caatgagtaa ctctaatagt tactcttgaa 2460

tctggattga aaaacaccat gcatctgatg agataattca taaatgttgc ccctttttta 2520

aatgatacaa ccctaaaagt gactgaattg cccaagtgct tgaacatggc agaggtagtt 2580

actcctattt tgcagtttgt gcacttaaaa attcctacag tgattgttac tttactgggg 2640

aaaaaagatg aggtgaaact tcctcccaag gaattaaaat atctgtagaa gccatggctt 2700

gcttttataa tgtggaaatc atttgatttg ctgtaattca cgcagatccc tccttttgtc 2760

agggggaaat gatttgcatc atgttctttt ttcataatgc ttttacttcc tgtttggatc 2820

agttgtatgt aaatgtacat ttttgttact ttggctgtgc ccgttagaat ttatcttcca 2880

taaagtattt ctcccattga gtctaatgat gtatactttg cctaggtctt tccaaaatta 2940

aatttatgta aatgtctatt ttatataaaa tatgattaaa ataagtatgt ctggtttcaa 3000

tctcaaaaaa aaaaaaa 3017

27

ggcagggagg aggaagcggt ggctgctgcg gatgtcggtg tgagcgagcg gcgcctgaac 60

acacggcggc tgccgagcgc ctgacccggg cctgcgccag agcctgcacc gagctccggg 120

gccccacacc cgctacggtg gccctgcgcc cgttgctact gaggcggcgt gctctgcatt 180

cttcgctgtc caggcctgcc ggctctggtg tctgctggct cctccttgct cgcctgctcc 240

ctcctgcttg cctgannnnn nnnnnnnnnn nnnnnnnnnn nnatggccga gagtggtgaa 300

agcggcggtc ctccgggctc ccaggatagc gccgccggag ccgaaggtgc tggcgccccc 360

gcggccgctg cctccgcggc gcccaaaatc atgaaagtca ccgtgaagac cccgaaggaa 420

aaggaggaat tcgccgtgcc cgagaatagc tccgtccagc agtttaagga agaaatctct 480

aaacgtttta aatcacatac tgaccaactt gtgttgatat ttgctggaaa aattttgaaa 540

gatcaagata ccttgagtca gcatggaatt catgatggac ttactgttca ccttgtcatt 600

aaaacacaaa acaggcctca ggatcattca gctcagcaaa caaatacagc tggaagcaat 660

gttactacat catcaactcc taatagtaac tctacatctg gttctgctac tagcaaccct 720

tttggtttag gtggccttgg gggacttgca ggtctgagta gcttgggttt gaatactacc 780

aacttctctg aactacagag tcagatgcag cgacaacttt tgtctaaccc tgaaatgatg 840

gtccagatca tggaaaatcc ctttgttcag agcatgctct caaatcctga cctgatgaga 900

cagttaatta tggccaatcc acaaatgcag cagttgatac agagaaatcc agaaattagt 960

catatgttga ataatccaga tataatgaga caaacgttgg aacttgccag gaatccagca 1020

atgatgcagg agatgatgag gaaccaggac cgagctttga gcaacctaga aagcatccca 1080

gggggatata atgctttaag gcgcatgtac acagatattc aggaaccaat gctgagtgct 1140

gcacaagagc agtttggtgg taatccattt gcttccttgg tgagcaatac atcctctggt 1200

gaaggtagtc aaccttcccg tacagaaaat agagatccac tacccaatcc atgggctcca 1260

cagacttccc agagttcatc agcttccagc ggcactgcca gcactgtggg tggcactact 1320

ggtagtactg ccagtggcac ttctgggcag agtactactg cgccaaattt ggtgcctgga 1380

gtaggagcta gtatgttcaa cacaccagga atgcagagct tgttgcaaca aataactgaa 1440

aacccacaac ttatgcaaaa catgttgtct gccccctaca tgagaagcat gatgcagtca 1500

ctaagccaga atcctgacct tgctgcacag atgatgctga ataatcccct atttgctgga 1560

aatcctcagc ttcaagaaca aatgagacaa cagctcccaa ctttcctcca acaaatgcag 1620

aatcctgata cactatcagc aatgtcaaac cctagagcaa tgcaggcctt gttacagatt 1680

cagcagggtt tacagacatt agcaacggaa gccccgggcc tcatcccagg gtttactcct 1740

ggcttggggg cattaggaag cactggaggc tcttcgggaa ctaatggatc taacgccaca 1800

cctagtgaaa acacaagtcc cacagcagga accactgaac ctggacatca gcagtttatt 1860

cagcagatgc ttcaggctct tgctggagta aatcctcagc tacagaatcc agaagtcaga 1920

tttcagcaac aactggaaca actcagtgca atgggatttt tgaaccgtga agcaaacttg 1980

caagctctaa tagcaacagg aggtgatatc aatgcagcta ttgaaaggtt actgggctcc 2040

cagccatcat agcagcattt ctgtatcttg aaaaaatgta atttattttt gataacggct 2100

cttaaacttt aaaatacctg ctttatttca ttttgactct tggaattctg tgctgttata 2160

aacaaaccca atatgatgca ttttaaggtg gagtacagta agatgtgtgg gtttttctgt 2220

atttttcttt tctggaacag tgggaattaa ggctactgca tgcatcactt ctgcatttat 2280

tgtaattttt taaaaacatc accttttata gttgggtgac cagattttgt cctgcatctg 2340

tccagtttat ttgcttttta aacattagcc tatggtagta atttatgtag aataaaagca 2400

ttaaaaagaa gcaaatcatt tgcactctat aatttgtggt acagtattgc ttattgtgac 2460

tttggcatgc atttttgcaa acaatgctgt aagatttata ctactgataa ttttgtttta 2520

tttgtataca atatagagta tgcacatttg ggactgcatt tctggaaaca tactgcaata 2580

ggctctctga gcaaaacacc tgtaactaaa aaagtgaaga taagaaaata ctcttaaagc 2640

tgagtatttc ctaattgtat agaatcttac agcatctttg acaaacatct cccagcaaaa 2700

gtgccggtta gtcaggtttg ttgaaaatac agtagaaaag ctgattctgg ttatctcttt 2760

aaggacaatt aattgtacag acacataatg taacattgtc tcaacattca ttcacagatt 2820

gactgtaaat taccttaatc tttgtgcaga ctgaaggaac actgtagtat accccaaagt 2880

gcatttgcct aggacttctc agcttctccc ataggtagtt taacaggcat taaaatttgt 2940

aattgaaatg ttgctttcac tgaaaaagtg tcttgatgtt tcagttattt ttaatcgcca 3000

taaaaaaata gaactatctt ttgggtttat ctgttttctc atgcacaggc aatacacaaa 3060

tttaaaatga gttgtgagcc aattgtttct gaagtgtttt ggtagttcta ttaagaaata 3120

gttaaatatt gtgcttttca gagcctcaga gaaaggggga cggggtgggg gggtggggca 3180

gcggaatctg tcctggatgg ggccagctta aataatactg gcaaccaaga ttctgttagg 3240

atttctgtgc atatagtgta gtaaagaagt atcattcagg ggtgaaaaac aaagagccgt 3300

tttaatgatg ttgagtacat ttggctgttt tatagccttt tcttccctcc cccaaagaat 3360

tctgtttgcc taactcccaa actgttgggg tggtacattc ctttaggacc aattaaaaca 3420

taattgaggg tcagtgatac atttggctga ctctggttca gtattctctt aggtgattat 3480

attctctcat gtacagttac aggaaattaa aatgttaaag taacctaaaa tgaattcaga 3540

ccaataaaat caagggaaat acaagttgat tgcattactt ctgtatgttg cttgctatta 3600

aaaaggttaa gaggccaggt tacccaccag tccttgcact gttctgacac tttccccagg 3660

aggaaaacaa gtacaaaggt tacggtggag gcataagtag aagagattgt taagaagggt 3720

attcatgtgt ctttgctctt tctgctttat gcctcagttt ggtttaaaaa cttctgtact 3780

ggcaaatggt ggtattcagt gtgggatagt gtcataacta atttgacaat ttattaatca 3840

taaaataaca ataaatctct agcttttaca cttgagaaaa aaaagaagaa aaaaagaagg 3900

28

gccgggacat ggtgccagtc gcaccccttc cccgccgccg ctgagctcgc cggccgcgcc 60

cgggctggga cgtccgagcg ggaagatgtt ttccgccctg aagaagctgg tggggtcgga 120

ccaggccccg ggccgggaca agaacatccc cgccgggctg cagtccatga accaggcgtt 180

gcagaggcgc ttcgccaagg gggtgcagta caacatgaag atagtgatcc ggggagacag 240

gaacacgggc aagacagcgc tgtggcaccg cctggcaggg ccggccgttc gtggaggagt 300

acatccccac acaggagatc caggtcacca gcatccactg gagctacaag accacggatg 360

acatcgtgaa ggttgaagtc tgggatgtag tagacaaagg aaaatgcaaa aagcgaggcg 420

acggcttaaa gatggagaac gacccccagg aggcggagtc tgaaatggcc ctggatgctg 480

agttcctgga cgtgtacaag aactgcaacg gggtggtcat gatgttcgac attaccaagc 540

agtggacctt acaattacat tctccgggag cttccaaaag tgcccaccca cgtgccagtg 600

tgcgtgctgg ggaactaccg ggacatgggc gagcaccgag tcatcctgcc ggacgacgtg 660

cgtgacttca tcgacaacct ggacagacct ccaggttcct cctacttccg ctatgctgag 720

tcttccatga agaacagctt cggcctaaag taccttcata agttcttcaa tatcccattt 780

ttgcagcttc agagggagac gctgttgcgg cagctggaga cgaaccagct ggacatggac 840

gccacgctgg aggagctgtc ggtgcagcag gagacggagg accagaacta cggcatcttc 900

ctggagatga tggaggctcg cagccgtggc catgcgtccc cactggcggc caacgggcag 960

agcccattcc ccgggctccc agtcaccagt ggtgcctgca ggcgctgtgt ccacggggag 1020

ctccagcccc ggcacanccc agcccncccc acagctgccc ctcaatgctg ccccaccatc 1080

ctctgtnccc cctgtaccac cctcagaggc cctgccccca cctgcgtgcc cctcagcccc 1140

cgccccacgg cgcacatgca tctctaggct gtttgggacg tcacctgcca ccgaggcagc 1200

ccctccacct ccagagccag tcccggccgc acagggccca gcaacggtcc agagtgtgga 1260

ggactttgtt cctgacgacc gcctggaccg cagcttcctg gaagacacaa cccccgccag 1320

ggacgagaag aaggtggggg ccaaggctgc ccagcaggac agcgacagtg atggggaggc 1380

cctgggcggc aacccgatgg tggcagggtt ccaggacgat gtggacctcg aagaccagcc 1440

acgtgggagt cccccgctgc ctgcaggccc cgtccccagt caagacatca ctctttcgag 1500

tgaggaggaa gcagaagtgg cagctcccac aaaaggccct gccccagctc cccagcagtg 1560

ctcagagcca gagaccaagt ggtcctccat accagcttcg aagccacgga gggggacagc 1620

tcccacgagg accgcagcac ccccctggcc aggcggtgtc tctgttcgca caggtccgga 1680

gaagcgcagc agcaccaggc cccctgctga gatggagccg gggaagggtg agcaggcctc 1740

ctcgtcggag agtgaccccg agggacccat tgctgcacaa atgctgtcct tcgtcatgga 1800

tgaccccgac tttgagagcg agggatcaga cacacagcgc agggcggatg actttcccgt 1860

gcgagatgac ccctccgatg tgactgacga ggatgagggc cctgccgagc cgcccccacc 1920

ccccaagctc cctctccccg ccttcagact gaagaatgac tcggacctct tcgggctggg 1980

gctggaggag gccggaccca aggagagcag tgaggaaggt aaggagggca aaaccccctc 2040

tnnnnnnnnn nnnnnnnnnn nnnnnnnagg caaagaggaa gaagaaaaag ctgccaagaa 2100

gaagagcaaa cacaagaaga gcaaggacaa ggaggagggc aaggaggagc ggcgacggcg 2160

gcagcagcgg cccccgcgca cagggagagg acggctgccg atgagctgga ggctttcctg 2220

gggggcgggg ccccg 2235

29

caactaacgg tgtttttaag ggggtctaag cctgcctttt caatgattta atttgatttt 60

attttatccg tcaaatctct taagtaacaa cacattaagt gtgaattact tttctctcat 120

tgtttcctga attattcgca ttggtagaaa tatattaggg aaagaaagta gccttctttt 180

tatagcaaga gtaaaaaagt ctcaaagtca tcaaataaga gcaagagttg atagagcttt 240

tacaatcaat actcacctaa ttctgataaa aggaatactg caatgttagc aataagtttt 300

tttcttctgt aatgactcta cgttatcctg tttccctgtg cctaccaaac actgtcaatg 360

tttattacaa aattttaaag aagaatatgt aacatgcagt actgatatta taattctcat 420

tttactttca ttatttctaa taagagatta tgtgacttct ttttctttta gttctattct 480

acattcttaa tattgtatat tacctgaata attcaatttt tttctaattg aatttcctat 540

tagttgacta aaagaagtgt catgtttact catatatgta gaacatgact gcctatcagt 600

agattgatct gtatttaata ttcgttaatt aaatctgcag ttttattttt gaaggaagcc 660

ataactattt aatttccaaa taattgcttc ataaagaatc ccatactctc agtttgcaca 720

aaagaacaaa aaatatatat gtctctttaa atttaaatct tcatttagat ggtaattaca 780

tatccttata tttactttaa aaaatcggct tatttgttta ttttataaaa aatttagcaa 840

agaaatatta atatagtgct gcatagtttg gccaagcata ctcatcattt ctttgttcag 900

ctccacattt cctgtgaaac taacatctta ttgagatttg aaactggtgg tagtttccca 960

ggaaggcaca ggtggagtta tttgtgagaa gcaaagtgtt tactaatgac aaagtagtaa 1020

accattttca agatgaaaac tgatttctat ttattttgct tcaaaggtcc tgaaaaaata 1080

agcaattatc ataacaattt gttattgata ctggaggttt cattgacatg tctctcaaat 1140

taaagctcac actgcctcca taaaagtctt caacatctaa tttataagct ttacaagtat 1200

ttattttata aggcttagac agaattattg gagttttaaa ttaagtgtat tggaaaagaa 1260

aggatggtat gtgtatgaaa tgttaagatc ctacgcaaca ctgctatttt tttcctttaa 1320

tatttgtgct gcataacaaa agccactaga ctgttactgt cttgtctgtc catgtgttaa 1380

cagcatttct taatgatgta tatatggagt ggtcttcaat catagtgaag aatttaaaga 1440

gaaagtcaat tgtattggca tttttaataa gaacaaaatt agttcgtcta aggggactgg 1500

ctggccacat atttgttcct tgcccatatg ctttctactt cttgttctta ttatgaaatt 1560

atgaatttga agcctctgaa atggtgatca gtttttcaac atctttcaaa aacaaaatta 1620

ctatttcctc catattgcct tttttagata actttaaagt taggatttta aaatatttgt 1680

aactggctaa attttaaagt cgtgacaaat aattacttag gttcagaaat atacacacac 1740

ttactcttta gccagtttct ttcaaggttt actgtcccat cagatatcta gccattttcc 1800

tttgcaaatt acataccttc ttaagagtgt atttttaaga ttattactta cgctttatga 1860

tgatatagtt tttcaaaatt atttatagct tcatatgatg ttttgtaatt ttttctattg 1920

atacctgttt taaaaatatt ttccaaggaa gttgattaaa attatatttg ttacctttta 1980

gaaaaagcat tgaaatgagt ttctcttgct ttttcatttt ccctctgctt tatatgctct 2040

tcgcaataca tcatgtccaa cgggatacct attgttctca tgacacccaa aattgatgag 2100

agcaaagggg tcgcaccata tggaaatgtt gaaaactatt gtaaagtagt attatgaagt 2160

agcttttgtg tcattcatgt cgatgacatg aaagtgaagt aaatttattc tatgtaaatt 2220

cacactaaaa ccagtacagt accataagta gaatacatgt aagaatcacc tagtcttcac 2280

tatattgagt aaatataaca tgctaatttt acaattaatg aaactaaact tttaaacatc 2340

tccattatat ctacatcctt ttgaaggtat ttatcatagt tgccaatttt aattttagga 2400

ttgactttct ctttctgaat gacttcataa agtttggtgt gaattttgaa gacttgggtt 2460

actaatgatt gtatctttgc tagtcaacaa cttatgaaat atactcaatg cgtctgatgt 2520

gtcattaagt gcagaaataa ctaagacaca aataaccttt gcaaaccttc aagctgtgta 2580

atattccaat gttgtttttt tctttgtata tatacttata tcacgtagga tgtaaaacca 2640

gtatgacctt gtctagtctc caaacttaaa ataaactttt gaaaagctgg gattcttttg 2700

aagcagttgt aattaaacac atttataaga atacaaa 2737

30

gaaaaatgta gaaaaacggc agagacagtg tcttacctag aatatctagt gatgttagtc 60

aatacatatt ttttcaaaca tttattctgg tttagttgct tttttctact gtccattttg 120

cttttctgaa gggattagat taaacgtggt tcattgatgc aacacagact tactgattgt 180

ttattgtgtg ccaggtactg ttatggtctg gaggtacaaa aaaatgcaca aaatttactt 240

gctgcctnag ggaagtaatg ttgattggat aattagactt ataagcagac agttcaggtg 300

tacatgtggg gctctggcat aaagaagagg actcagacca agctggggag ttgcttaagg 360

aaggcttcca ggaattggag tctcttaagc tgattttaaa gggtgaataa aagtggacca 420

tgcagataat ctgttggaaa atgggttgga ggttatctca gaggaagtca cttgcctaca 480

tagagaacat gatgaatgta agatgaattt gaatgtacag gtcacatgta ggataggtaa 540

agagtcagtc caaaaacaga atatgagggg cttgtgtccc gtgttgtgga acttgcattc 600

ctgactttcc tcctccaccc cactgagatg ctagagagta actggagaat tttgagtagg 660

gaagtgacct gttgatcagc tattcttgtt taaaagctca ttctaggggt agcatgggat 720

atagctgtga cttaagccaa gagttctgtt agggggatag aagagaatga ggtcctaaag 780

ttcagccgcg atagggagaa tgactgtgag agttaactta ggctgaatta gtaggactgt 840

tgatggaata tgcaggtagg aagaagagag tgaattcttg aatgctgtcc ttaggtatct 900

gggtggagcc ctttaccaag atagatgatg caggtaggac aggttttggg gtgttgaatt 960

cagatttagc catgtctgtt tgatgagtct gagtgacaca gaatagaaat agggacatag 1020

agatatctat ttagactaaa tctgtaatat gttctattct aaatggaatt atactccaga 1080

agaaaataaa ctgatttaaa atagcttgtt acagcacttc aggtgttttt ttcttacact 1140

aatgattttg ttttacggct gaaaagtaaa atggccaact tgagaagcct aggtataata 1200

tgccttagat tatatttttg aatggaatta ttgttcttta cctgataatt tatattggtt 1260

acttggcctt taaatctttc ttcttaccta actttctatt ctactattta aggggaaaga 1320

taaagggtca ttataagagg gctgtggaat gatttaaaat ggtgggtgaa gggtaaaact 1380

gaaagtgttt attaggaaag taaagctatt catgttttta caggtaactg aagatcaaag 1440

taaagcaaca gaggaatgta catctaccta ataactttct aaaatttaaa tatgtataat 1500

aaaataaatg ttttaaatat 1520

31

gtggagcaga agccacagtc acttcctgaa ggcagcggcc ccagctcggg tcccactcat 60

cccatggccc atcacctgcc tgcagccatg gagagccatc aggacttccg gagcatcaaa 120

gcaaagttcc aggcctctca gccggagccc agcgacctgc ccaaaaaacc tccgaagcct 180

gagtttggta aactgaagaa gttctcccag cctgagctaa gcgagcaccc ccagaaggcc 240

ccgccgcctg agtttggtgc agtgtccttg aagcccccgc agcctcagtt cactgacctt 300

ccccaagaag gccccgcngc ctgaggtcac tgactccccc aagaagcccc cgncggctga 360

ggtcactgac ctccccaaga agcccccgcc gcctgaggtc actgacctcc ccaagaagcc 420

gtccaaactg gagttgagtg acctctccaa gaagttccca cagctggagg ccactccgtt 480

tccaaggaag cccctgcagc ctgaggtcgg tgaggcccct ttgaaggcct cgctgccgga 540

gcctggtgcg ccggcccgga aacccctgca gcccgacgaa ctcagtcacc ccgccagacc 600

cccctccgaa cccaaatccg gcgcattccc caggaagctc tggcaacccg aggccggtga 660

ggctaccccg aggtccccgc agcctgagtt gagtaccttt cccaagaagc ctgcgcanct 720

ggagttcaac gtgtacccca aaaagcctcc gcagcctcag gtcggtggcc tccctaagaa 780

gtccgtgccg cagcctgagt tcagcgaggc cgctcagact cccctctgga agcctcagtc 840

cagcgagccg aagcgcgact ccagcgcctt tcccaaaaag gcctcccagc ctccgctgag 900

tgactttccc aagaagcctc cgcagcctga gcttggggac ctcaccagga 950

32

ctgcactcca gcctgaacag agtgagatcc tgtcaaaaaa gaaaagaaaa agaaagcagc 60

attcaaatgt aagacaactg taaaatattg agccccactt ggtctaaaat tcaaaaagaa 120

gaacgcctgt ccatcgcctt tttataagtc cttctctcca cacctaaaag cagctgcagc 180

tggaagggca caaattccac tgtgtaaaat aaaatattag gggcaacaca cttcatcaag 240

gcatgcacgg aatgagagag agcagagaag atcaaggatg aagtcttggg tactgaaaaa 300

ttcagtgctg ggcagaaaaa ctgacagggc agtacaagta acaaacagaa tccaagtggg 360

gtggcccttg tgcacagagc tccaggtgac ctctggagag acatgggcat tcacatggaa 420

agctaaaacg gaagctcaag tttcatactc aacataatct tctgtgtgac aaaggacaag 480

ccatgtagcc tctctgtgcc tatttcttca tgcataaact gggactcata atatttgtaa 540

aatgtattga tactctcagg gcaaattcac tatattgcta tacagttgag atcagtgttg 600

taaaattaaa ctgatctggt tctaattgcc tcaaaggcca aagcccaggc atttgaaatg 660

gaaagaagca gagaggaggc tgacttagct gattggtatg gaaacagttg ggccaagagc 720

cagaatttcc ctttgtagca acacggctag ttttactttg agaagctctg ctcagctgct 780

ttataacatt aagtctggcg gaatggatgt cactgtgcac aataaagttt tcacaagtat 840

aaacaatggt gatgtaagtc aacattggct gtagccaggt gtgaaggttg tatggtgtgt 900

gacgaatgta catcatgttt gtaggtttgg atgctaatct tgaattgtag cttaaaaaat 960

acgtattttt gtaactcttt gaaagtttat gaagactgac agctttcctt gtaagcacta 1020

agagaaaaaa aagaaagagg gacatttgac aattttaaag aaacaacaag aaattagaat 1080

gaaaatctgt gacaaacagc gtcagtgtgg ccatgtccac attcctacat gtctctctct 1140

acaagcacct ctctaagaag cctgacatcc cggtggactc tttatagtca tgtacacttg 1200

attccagatg agctctggtc ttatctggat gctcagataa gaggtttcta tctgaggcat 1260

ccagatgttc cctcaggttc caagacattt caccccaggc cctggggttc actctggaat 1320

tcgtaggctt cacgtctctc tagaaatgac gtgtaaaatt taagaccaga cctcagccat 1380

cagcgtccag accatcctag aagtctttcc caatctcaca gagaaagccc tagtatttcc 1440

cagtgacccc aggattccac gttggggtgg ccaaagaaat aggtctctca gggctttgcc 1500

acagcctcca gcccatcctt cagaggcaca cacagcacct ctcggctgct ccagctctgt 1560

aggatagcct cccctggggt ccgtgggacg cgggccacag tgttgaggta gacaaggagg 1620

atcagtgaga ggcctcttcc ctctccacag agactggatt gtcattgttc cttcatttat 1680

atcgtagggc ttaacatttc actcaaaaaa aagcccctct ttttctaatc cttagtcttt 1740

gtttcaagga aagccagttt ttcttctacc acattttcca ggatcgactt taagaaaaat 1800

gcaacatcta ttgaaaaaaa gtggggtgta tgcatgtggt ttaattccag attgcttttg 1860

ggtttaagtg gtatcaaatt tcagtatatt tctgtcttat gtgaaagaaa tatattacta 1920

aaacgtcagt gagcaataat gtcagctgtc aagcactaga tttatttttg caggatatgg 1980

agtgcaatga actgagtcaa tatggcaagg tgtatgtgat ctgtgggagt tatgccattt 2040

aacataggaa gtgcatggga ctttccctct ctgcactcca gctcttactg taccattaga 2100

agatgcagaa ttctgttggt gtgcaaaaag tatagcctta cattcaagca gaatggatct 2160

gaagaaagca gcaatatctg ttactagaga acattcccat gtgtttaaac tcttcacttc 2220

ttagatgcat ttaaattctt aatgcaaatg acgtagcaat ttgaaaactt ctccgtatta 2280

cttgtgttta aaatgtcttg ctttaaatac aaaacaaatg gtaaagggga ttatcttttg 2340

tttagatggt taaatattat ttttgcctta gatagctttg taataatttt tctccagaca 2400

gttcaacact tttgaaaaat gacatgaatt ttcattaaaa acccttttcc tatgtttatt 2460

gtatacaaga attatgcaat aaaatttctt tataaaa 2497

33

aacaaggatc ataagagaat gtttggaacc tacttccgag ttggtttctt tggatccaaa 60

tttggggatt tggatgaaca ggaatttgtc tacaaagagc ctgcaattac caagcttcct 120

gagatctcac atagactaga ggcattttat ggtcaatgtt ttggtgcaga atttgtggaa 180

gtgattaaag actccactcc tgtggacaaa accaagttgg atcctaacaa ggcctacata 240

cagatcactt ttgtggagcc ctactttgat gagtatgaga tgaaagacag ggtcacatac 300

tttgagaaga atttcaacct ccggaggttc atgtacacca ccccgttcac cctggagggg 360

cggcctcggg gagagctgca tgagcagtac agaaggaaca cagtcctgac cactatgcac 420

gccttcccct acatcaagac caggatcagc gtcatccaga aggaggagtt tgttttgaca 480

ccgattgaag ttgccattga agacatgaag aagaagaccc tgcagttagc agttgccatt 540

aaccaggagc cgcctgatgc aaagatgctt cagatggtgc tgcaaggctc tgtgggagct 600

actgtaaatc agggaccact ggaagtagcc caagtgtttt tggctgaaat tcctgctgat 660

ccaaaactct atcgacatca caacaagttg aggttatgct ttaaggaatt catcatgaga 720

tgtggtgaag ctgtagagaa aaacaagcgt ctcatcacgg cagaccagag ggaatatcag 780

caggaactca aaaagaacta taacaagcta aaagagaacc tcaggccaat gatcgagcgg 840

aaaattccag aactgtacaa gccaatattc agagttgaga gtcaaaagag ggactccttc 900

cacagatcta gtttcaggaa atgtgaaacc ccagttgtca cagggcagct aagaaaagcc 960

atcttcattc gtggagactg tggccctgca accctggaga aggacttgct ggtacttaaa 1020

aaatgggaca tttgccaccc aggactgact gtacactccc tgatcagcca gcactctggg 1080

aagctttggg atcccaggaa ccatggaatt attcccaaat ggactctgac cagatttttg 1140

ccatactggg gggtggcggg atggaggatg ggtactcagg catgactgcg tatttattaa 1200

agtgtgtttt tccacaatgt accaaacaag gcataagcag cttctcctgc tgactggcca 1260

atcactgccc atctgagaga tgatttcctc tggcccatat ttgaatttat tggagtaact 1320

caaattgcct gaggaaaaat ggaaaaatta tccaccagtc gattcaaact gaatttcact 1380

ctttatagga aggcagggca aacttgtagg agtacgaaac attttcaata aatctacaaa 1440

gggaagcctt actacaattc caaaaatcat catggttgga aatttgggag gagattattt 1500

gtgaacttgt tacccttttg gtaatggtgg actaattgct gtatagttat ttttgtttta 1560

ttattactgt tacattaatt taacatgcat ttatagaaga atacattcaa agcactgatg 1620

taggagatac acggtacttg gagcagtcag ccaaaaatca cagatactgc tttcacttaa 1680

atggaaacaa ttctccgata atgctttgct ttttttctta tgtcactctt gtgtactatc 1740

tatttttctc ctctctggga ccaagtttct ttttataaag caataatatc tctgttttca 1800

tttcagaaca ttgtgctgtc tgtcagcata tgtatatcag ctacaaaata tattcaactt 1860

tgacttcttt tgacaaagga ctttaggaaa aagaggaaca aagacattat ttgagaatta 1920

aattatatat ttttaatatg actgtgacct tgactgataa taaagatgta ataagaattg 1980

caagctaaat gtttcccttt gcaactcatg ctttgtgttt tgttttgatg acctactcgc 2040

tcgtaatgtt ttgtaaggca cttcagagag aagacagatg catcatcctg gcctccatca 2100

aataacacta tccaaggtgg cacctcttct gcaatgttta accctgctag taatgaacga 2160

tgacttagtt cggatatttc agaacttttt gtttatacca tcaggtatgc atgaatttat 2220

aatct 2225

34

tcacccactt tcacactcca ctgttaagtt ctgcatatcc tacggttttt taatgcacat 60

ataagcatat ggctcttcac aaatgggatg ataccatata tacattctat aatttaagaa 120

aaaatggctt tcagtatatc tagatctatc tataacagct gtgaggtatt ccactacatg 180

gatgtggcaa aattcattta actaaaacca aactaatagg catgtgttgg ttgtttttac 240

tgggccatta gcaacagtgc tatagtaaac atcattttga ataaatctct atacaattgt 300

tcaagtacgg agggataaat ttctagaaat aaaatttctg gatgaaagaa agcatgggaa 360

tgacttttat ttggatacat atccatcaaa agtgggagaa tgccattttc cccacagcct 420

caccaattct tcaccaatct gacaggtgga aaaagtgtgc cccaactacc ttttagagtt 480

tctctgccca gcagtttcca gtgactgtac atgcaaatgg aaaagtccca ttagaaatag 540

ttgacccaac acagttgcaa tcaagtatct gagctaagta cacaccagca aattactaaa 600

aatatccaga aaaactcaag cttcataaaa cctcaaattt caaaaaaagg atgctaaaat 660

ccacataggt cacttgtgtt ggcctggcct aaacagaccc ctcaaaggaa ctttggaggg 720

aaattgtttc tctaggtaag gaataacagc ataaagggaa aaaaattaaa attgttagat 780

acaggattct ctctagatct gccctgtcca atatagatgc cactaaccct cgtg 834

35

ggaaatggga tgggcacctg ggagaatctc cacgtaactt cagaaagggg tggcagatgg 60

ttttcaactg acaagttgaa ttgattggta gtggctccca gaggattctg aggtggtctc 120

catgttgggt gggcaagaga gattgactag tgatgactgc cacagaatgg agaggagggc 180

cctttacttc tttgaaccct aattttctca cgtataagcg gagaccctgg cccctcccgg 240

gcacagagta agctctgagc aaaggaggca atgctgttcc catcagtaag gctgcggaaa 300

ccaccacctc cctctnccca ccaccccgct ccttaacacc acctccagtc acaacctggt 360

gatgaaacac ctccctgggg ccgaccctga gctcgtgctg ctgggccgcc gctacgagga 420

actagaggtg aggccgtggg aggtgggctg ggggcgaggc cagaggcgag gcccagcctg 480

ctgaccccgc ccctcctccg cctcagcgca tcccactcag tgaaatgacc cgcgaagaga 540

tcaatgcgct agtgcaggag ctcggcttct accgcaaggc ggcgcccgac gcgcaggtgc 600

cccccgagta cgtgtgggcg cccgcgaagn ctccagagga aacttcggac cacgctgacc 660

tgtaggtccg ggggcgcggc ggagctggga cctacctgcc tgagtcctgg agacagaatg 720

aagcgctcag catcccggga atacttctct tgctgagagc cgatgcccgt ccccgggcca 780

gcagggatgg ggttggggag gntctncnaa ccccactttc t 821

36

gaaagccgca gcctcagtcc cgccgccgcc cgctgcgtcc gcccagcgcc agctccgcgt 60

ccccgaccgg cccgcggcag cctgcgccgc gccatggcca cctccccgca gaagtcgcct 120

tctgtcccca agtctcccac tcccaagtcg cccccgtccc gcaagaaaga tgattccttc 180

ttggggaaac ttcggaggga ccctggcccg gaggaagaaa gccaaggagg tgtccgagct 240

gcaggaggag ggaatgaacg ccatcaacct gcccctcagc ccaattccct ttgagctgga 300

ccccgaggac acgatgctgg aggagaatga ggtgcgaaca atggtggatc caaactcacg 360

cagtgacccc aagcttcaag aactgatgaa ggtattaatt gactggatta atgatgtgtt 420

ggttggagaa agaatcattg tgaaagacct agctgaagat ttgtatgatg gacaagtcct 480

gcagaagctt ttcgagaaac tggagagtga gaagctaaat gtggctgagg tcacccagtc 540

agagattgct cagaagcaaa aactgcagac tgtcctggag aagatcaatg aaaccctgaa 600

acttcctccc aggagcatca agtggaatgt ggattctgtt catgccaaga gcctggtggc 660

catcttacac ctgctcgttg ctctgtctca gtatttccgc gcaccaattc gactcccaga 720

ccatgtttcc atccaagtgg ttgtggtcca gaaacgagaa ggaatcctcc agtctcggca 780

aatccaagag gaaataactg gtaacacaga ggctctttcc gggaggcatg aacgtgatgc 840

ctttgacacc ttgttcgacc atgccccaga caagctgaat gtggtgaaaa agacactcat 900

cactttcgtg aacaagcacc tgaataaact gaacctggag gtcacagaac tggaaaccca 960

gtttgcagat ggggtgtacc tggtgctgct catggggctc ctggagggct actttgtgcc 1020

cctgcacagc ttcttcctga ccccggacag ctttgaacag aaggtcttga atgtctcctt 1080

tgcctttgag ctcatgcaag atggagggtt ggaaaagcca aaaccgcggc cagaagacat 1140

agtcaactgt gacctgaaat ctacactacg agtgttgtac aacctcttca ccaagtaccg 1200

taacgtggag tgaggggctg ccctgggccc accactgccc aagagttctt gctgttggcg 1260

tactggaccc tcctccgaac tgccttaccc tgcttattcc tgtctcttgc actgtgctct 1320

cccacaagtc cagctgcaac ccagagatag tggaaactga aattaggaag gaaatcatca 1380

ataactcagt gggctgaccc atccctccca ggcgctgggg accaacctag caatgaaggt 1440

tgggaaggtt gttcccttcc cggtgccagg tccagatttc cctccatgat ttgggaacca 1500

ggttaggcaa aagagtcccc acaagatgaa aataaagatc ctagttacca ttcaaaggat 1560

gctaactgtg tgtcaggccc cacactaagt gctctgctct gatatactca aggccattaa 1620

tcttcaggac tcccattgac gtaggtgttt cattcccctt ttacaggntg aggcaactaa 1680

ggcttggagg ttaaatgact tgccagaagt tggaattttt ttcctctttg aacataacct 1740

ctcccttctc cctaaaggta accactattc tgagtccaat catcaaggtt ttgcttttct 1800

ttttagctaa gtatgcattc ctcaatagta gacagtacaa catgtttata acaagccaat 1860

tacattatgt tctttgcatg ttctaaagtt gtgtatgtgt gtgcacatct gagcacgtgc 1920

acatgtacac ctgagccaaa aacacgagaa cccactgatc tcaccactgg ggcaagctag 1980

gtcagagctt agtgattcac actgaaattg gcaaattgga tttaacccaa ttaatagtgt 2040

gtgtgtggca ggagtcatgt ccctcacatc ctttgtacaa atgaaaatta ctcttaattc 2100

cttcagattt ataataactc tgtactttgg tttcagggtg acatttggga aggattttgt 2160

ttagaattaa tggagtggca cattttgcag cctttttgct tgattgcatg taatggaaat 2220

gccctatatt ttcctgcaaa ataagtacta aattcattat cgttaagcaa atgtacaata 2280

tggctcaggc accgcagaga gctgggcacg ggcccatgtg agcatcactt tggaagtagg 2340

gctcttcaac agggaccctt gaactttaaa gaaaggaact tctttttgcc ttctaattga 2400

tcatttagac tattctggct aagtctgccc acatgtaatt accggctaat tcaagcgagg 2460

aaaaatgtaa gtcatttaga ccaaagccaa gcagtttctt tgcgtgggtt actcaagggc 2520

ttgtggttac ttgtatctcc tctatgtgaa cttgactttg aaagacagag ctctagtgtg 2580

ccagcctgct aagtcctgta agaataggga agggcggagg ggggtgggca gtgactaggg 2640

gacgagaagc atggggaaaa tatttgcact ctaaacatac agagatagag gtggggcttg 2700

tggtacttaa cacttgtagc catcaactga ctgagacctt gggctaaata atcaattgtg 2760

ctgatattac atctcgttat ggaatgttcc taaatatgcc aggtagacac cagcccaagt 2820

accctcctcc agaagtctgt gactaccttg tcactacttt aggcccattc cacaaagccc 2880

atctctggtt tgagaattca ttttgatctg tatctacacc acccaaagtt aggcctccta 2940

taatgtccaa aacattcctt tcagcctttt tatttcttac tgtactgtct cttactgtac 3000

tgtctatctg cagtaattga ggacccataa aatttagata actacatgtc tttgctctta 3060

gaattgtcac tcagcataat gagcatttaa catacaaagg caatgtactg ttttgtgttg 3120

atctatgtaa aagaatacaa ttctttttta cataattagt gaaattttat tttttattag 3180

gaaacactaa atagtgtaat atttcttttg cttttaaaaa aattcctggt agcaaatcaa 3240

gataaataat tgcttcattt tcttgagcaa tactgaagca ggatgaagta agaggaatgc 3300

attcatttaa acatgctttg ctttatgaat tttgtctctt ttttggtctc tttttcttat 3360

attcaagtta caaatgtaca agtatcctta ctaagagtgc tccttttgta ttttacatat 3420

atacagtatg aaaatacatt ggaacactag gaaagttttt aaataacagt tctaatttat 3480

cagaaaattg tgttttggga ttgagttctt tgtctcagcc cagaatccca ggtcctgggc 3540

ctggttttct aatgctgtca tctcagttcg atattttact ttagaatctg gaatctccta 3600

cttaatatat gaccatgact ttgaaaggca aaagaggaat caagaataaa taaaacaaac 3660

ttaatcttca tctttaaaaa aaagaaaaaa gaaaccaaaa tgagaatcaa cacttcatag 3720

gctcactggg ttttcttttc ttttctgtta atttaaactc agttattttt aatgcttaat 3780

acatacatgg tgcaaaattt aaaaagcgca aataggtatc tagtggaaaa cctaagcctc 3840

cctctctcct ccggcaccca ttacctctcc ctggaggcaa ctgttttgat ccatttctta 3900

cacacactgc cagagatact ctaggcatgt aaagcacaaa catacatata aaatctgcgg 3960

gcttcaaaaa atataagtag gatgtcatct atactgtnnn nnnnnnnnnn nnnnnnnnnn 4020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnctgt tctgcagggc ttcagcgtgg 4080

ccttcattcc cgcctcgcct cggcctcttt tcaattaaga agtgatgcca cttgaggcag 4140

ggtctgcatg atcacttctt gggtttgagt ttgaaagctg ccatccctgc gactgcccag 4200

ggcctgtatg ttgggaccga agccaaacac cactgtcctc cagggggctt tcggcccggg 4260

gcagggtccc cagtgcccgc cttcgaatca gactccgcgt ttccgcctct ccctgggcgg 4320

acctgccgct agagggcgct cctcctccgc agccggcgcc ggcctccagc gccccagact 4380

cccgcgctgc cgcccgagcc tgaggtttct cacggcgttc gggattcgcg cttcggaaac 4440

cgggaacaaa gaagcaagca gcacccttca gaaacagtgt tctcgctctc ctagcagctg 4500

gcccgggccc ggaggctggt gccaggagaa ggcagaagag cccgggcagc cggagtgggc 4560

tacggggttc aggcagtgcc aaggaagaag ggcctcacaa tgggcaattc agctgcctcc 4620

cgggccgttg tccccgctgt cttcaaacag gggtcccctg tcccagctgc cccaggagga 4680

gcgggggagg caggcagggc cgaaaccctc cagagcccag agggggacgc ttggtggccg 4740

ctgcagttac ataaccatag gatgnttttg taccgtggac cttgttctag caggatcctt 4800

tcggaattgc anttttacat gttgggcgaa tttgtgtccg tgctgaagtt tattaaagga 4860

aaatagatgg aaaa 4874

37

ccaggagaag gaagccaaca ggatccgacc cggtgttttg tgacaaaggc aagaccccca 60

ggtctactta gagcaaagtt agtagaggag gcagctaggc gtggctctca ttccttccca 120

cagaatggat tataagtcga gcctgatcca ggatgggaat cccatggaga acttggagaa 180

gcagctgatc tgccctatct gcctggagat gtttaccaag ccagtggtca tcttgccgtg 240

ccagcacaac ctgtgccgga agtgtgccaa tgatattttc caggcctcta acccgtattt 300

gcccacaaga ggaggtacca ccatggcatc agggggccga ttccgctgcc catcctgtag 360

acatgaagtg gttttggata gacatggggt atatggactt cagaggaacc tgctggtgga 420

gaacatcatc gacatctaca aacaggagtg ctccagtcgg ccgctgcaga agggcagtca 480

ccccatgtgc aaggagcacg aagatgagaa aatcaacatc tactgtctca cgtgtgaggt 540

gcccacctgc tccatgtgca aggtgtttgg gatccacaag gcctgcgagg tggccccatt 600

gcagagtgtc ttccagggac aaaagactga actgaataac tgtatctcca tgctggtggc 660

ggggaatgac cgtgtgcaga ccatcatcac tcagctggag gattcccgtc gagtgaccaa 720

ggagaacagt caccaggtaa aggaagagct gagccagaag tttgacacgt tgtatgccat 780

cctggatgag aagaaaagtg agttgctgca gcggatcacg caggagcagg agaaaaagct 840

tagcttcatc gaggccctca tccagcagta ccaggagcag ctggacaagt ccacaaagct 900

ggtggaaact gccatccagt ccctggacga gcctggggga gccaccttcc tcttgactgc 960

caagcaactc atcaaaagca ttgtggaagc ttccaagggc tgccagctgg ggaagacaga 1020

gcagggcttt gagaacatgg acttctttac tttggattta gagcacatag cagacgccct 1080

gagagccatt gactttggga cagatgagga agaggaagaa ttcattgaag aagaagatca 1140

ggaagaggaa gagtccacag aagggaagga agaaggacac cagtaaggag ctggatgaat 1200

gagaggcccc cagatgcaga gagactggag agggtgggga ggggcccagc ggccttggtg 1260

acaggcccag ggtgggaggg gtcggggccc ctggaggggc aatggggagg tgatgtcttc 1320

tctctgctca gagagcaggg actagggtag gaccctcacc gctgcgtcca gcagacactg 1380

aaccagaatt ggaaacgtgc ttgaaacaat cacacaggac acttttctac attggtgcaa 1440

aatggaatat tttgtacatt tttaaaatgt gatttttgta tatacttgta tatgtatgcc 1500

aatttggtgc tttttgtaaa ggaacttttg tataataatg cctggtcatt gggtgacctg 1560

cgattgtcag aaagagggga aggaagccag gttgatacag ctgcccactt cctttcctga 1620

gcaggaggat ggggtagcac tcacagggac gatgtgctgt atttcagtgt ctatcccaga 1680

catacggggt ggtaactgag tttgtgttat atgttgtttt aataaatgca caatgctctc 1740

ttcctgttct tcaaagg 1757

38

ggctagtgca aggatcagat agcacctgct tggaagttca ctgattaatg atttaacaag 60

ggcggtcaca tgggacaact gctgcttttc tctgccctca tttttcttac taacaggtct 120

gaaaattgaa caagatggac gggtccagga aagaggagga ggaagacagc acattcacca 180

acatttctct tgcagatgac atagaccatt cctcaagaat tttgtatcca aggcccaaaa 240

gtttgttacc caagatgatg aatgctgaca tggatgcagt tgatgctgaa aatcaagtgg 300

aactggagga aaaaacaaga cttattaatc aagtgttgga actccaacac acacttgaag 360

atctctctgc aagagtagat gcagttaagg aagaaaatct gaagctaaaa tcagaaaacc 420

aagttcttgg acaatatata gaaaatctca tgtcagcttc tagtgttttt caaacaactg 480

acacaaaaag caaaagaaag taagggattg acacccttct gttttatgga attgctgctg 540

atcatttttt ctttaaaact tggacagatt ccaaaaagtt acagtacctt tgtggcttca 600

ttgaatattt atgaagataa tgtcagatgt agacaaaaat aacacaataa caggagactt 660

ccataagttt gtgtattatg ttagtctatg aaaacgtgca aatgtattgt agagacttta 720

tgattagaat tgcatatatt tatgaaactt aaagatgaat gttttattga atttgtaggt 780

ttagcactgt cttttattat aggattagta agatatacaa gaaaataacc accgtgttgt 840

gaaaaagtga ccaaaatcat gtactaaatg cacagcttta tgtaccctgt ccaccatctt 900

gtgcctcttc tccatttgcc tcttccttcc tatttccctt ccgctaagga aaaaaattgg 960

tgtcacattt gtaaaagtaa ttttaatagt taatccatct ctgagagtaa cctgtatttt 1020

aattgttgaa acttaaccaa aataagatac tgtctcagct aggggcttgt catttgtgta 1080

tttagtgtta agataggaat gctagtgtct ctttaattaa ttggaaatat atggaggcta 1140

aaaatgaagg tttttctttg aaactgaatt aacttgggaa tatttgttgt taaaaacttc 1200

tttttgccca aaataactca ttttgtatta tctgaaaata tataatttct ggtcatgtgt 1260

atgttaaaat agaaaatttt gaggaaaaat ggaaataggg tggaaaagta ctcggtaaac 1320

agtagtaacc aaatattttc actccagatt tgtgttttct ctggcacaga gtagatcttt 1380

tgggaaatat atatgaaagt ggattaagtt tgactaccct tatgttagcc acatctggat 1440

gagaacagtt acaaagagtt tggtctctaa gttgatttgt acccagtggg tcaacttctg 1500

caaaattccg taatggtgta ttagtattag aatagtgaat aaaatgggaa agttatacat 1560

gtatacttat tatcttgctc agtattttat ctcacttgtt ctagaatttt ctgtaaaccc 1620

tgctactggg tttgaagagt tttagtcatc ctttaacaat ttttaaaaat ttagcttcta 1680

gattccattt ggtaaggaaa tcaatattgg aagtattgct aaaatcttat aatatgaaaa 1740

gagatccact aatgtagctt aaggttatta gatttgggct tttaatcatg gaataatctt 1800

atgtattggt gtaagagttg atgaatgact ttagctgtgt gaatatataa tagtcaaact 1860

gcaaacattt tgcatccctt ttgtgaccta atttacagac atttaaattg tgttgcagtt 1920

ctgctttgcc gtttaataaa aagctatttc agaggt 1956

39

atgggggcag tgaatgtcgc caaagggacc gtccagacca gtgtggacac caccaagact 60

gtcctaactg gtaccaagga caccgtctgc agtggggtga ccggtgctgc gaatgtggcc 120

aagggggccg tccagggggg cctggacact acaaagtctg tcctgactgg cactaaagac 180

accgtatcca ctgggctcac aggggctgtg aacttggcca aagggactgt ccagaccggc 240

gtggacacca gcaagactgt cctgaccggt accaaggaca ccgtctgcag tggagtcact 300

ggtgccgtaa atgtggccaa aggcaccgtc cagacaggtg tggacacagc caagacggtg 360

ctgagtggcg ctaaggatgc agtgactact ggagtcacgg gggcagtgaa tgtggccaaa 420

ggaaccgtgc agaccggcgt ggacgcctcc aaggctgtgc ttatgggtac caaggacact 480

gtcttcagtg gggttaccgg tgccatgagc atggccaaag gggccgtcca ggggggcctg 540

gacaccacca agacagtgct gaccggaacc aaagacgcag tgtccgctgg gctcatgggg 600

tcagggaacg tggcgacagg ggccacccac actggcctca gcaccttcca gaactggtta 660

cctagtaccc ccgccacctc ctggggtgga ctcaccagtt ccaggaccac agacaatggt 720

ggggagcaga ctgccctgag cccccaagag gccccgttct ctggcatctc cacgcccccg 780

gatgtgctca gtgtaggccc ggagcctgcc tgggaagccg cagccactac caagggcctt 840

gcgactgacg tggcgacgtt cacccaaggg gccgccccag gcagggagga cacggggctt 900

ttgaccacca cacacggccc cgaagaagcc ccacgcttgg caatgctgca gaatgagttg 960

gaggggctgg gggacatctt ccaccccatg aatgcggagg agcaagctca gctggctgcc 1020

tcccagcccg ggccaaaggt gctgtcggcg gaacagggga gctacttcgt tcgtttaggt 1080

gacctgggtc ccagcttccg ccagcgggca tttgaacacg cggtgagcca cctgcagcac 1140

ggccagttcc aagccaggga cactctggcc cagctccagg actgcttcag gctgattgaa 1200

aaggcccagc aggctccaga agggcagcca cgttctggac cagggctcag gtgccagtgc 1260

ggaggacgct gctgtccagg aggagcggga tgccggggtt ctgtccaggg tctgcggcct 1320

tctccggcag ctgcacacgg cctacagtgg cctggtctcc agcctccagg gcctgcccgc 1380

cgagctccag cagccagtgg ggcgggcgcg gcacagcctc tgtgagctct atggcatcgt 1440

ggcctcagct ggctctgtag aggagctgcc cgcagagcgg ctggtgcaga gccgcgaggg 1500

tgtgcaccag gcttggcagg ggttagagca gctgctggag ggcctacagc acaatccccc 1560

gcttcagctg gctggtaggg cccttcgcct tgcccgctgg cgggcagtag ctgtaggagc 1620

ctgcaggccc ggcgcggggt cgccctgctc tgtccaggga ggagctgcct cagaactttc 1680

tccccgcccc caaacctgga tcggttccct aaagccctag acctttgggg ctgcagctgg 1740

ctgagcgccg aggggctgcg gaggcagtga ccttcttaac tgagccaccc cacgccctgc 1800

tccgggcctg cctgcatctc ccacctcctc cccagcgctg cctgcccctc tcggagcctg 1860

gggtcactca gaccaccagc caagagcctt cccttgaagt ccccaagcaa gcactgcaat 1920

taggaaagag aaaaagcagc gtgcccagcc tggaagggca tctgtttgcc ccgctagcaa 1980

cccttttata tctagcaggg gctcttccag tcctgcagca cgggccccca gctatcagcg 2040

gtgcaggcag tgctgtggca tcccaggctc cgggcagctc cgttctcatg ctgaaagtgg 2100

gtctccggcc ttagcacaca caccttgagg gtcttaagaa ccacattccc tcatagtaga 2160

aagtactaga aaaagcgaca ctgccatcat catcccaagg caggctgcta ctgcctttgc 2220

tgacccccgg ggtggcctca cggtggggac aaagctgcca ggagccacag cagccacagc 2280

tgggggcttt gcaccagcct ggcttgagac tgagcagttt gcagggggtg gggggtgcaa 2340

aaaacaagca aacaggctgc tgctgcctcc agctgcccac cacaggcctg ccccaggcac 2400

ctggggctct gaggcccctg gggaggctgg ggcccagcag ctgcccctgg gaggaacaca 2460

gacaaaggac ttccccgcag ggaactgtgc cctatggagg gatcagacag ggctgggaac 2520

agccacagag gctgcgtgcc tatggcacag cccttcctcc gccgcacact ccccctgggt 2580

cctcaggccc acccaagcgc cgggctgcag aggaagcggg gctggggagg ctgcaggcat 2640

cagagacact ggtggtggcg gacccggccg ccgggccccg tgctctcagg ctagcccagg 2700

tcgtggaggc tggcaggctc aggtcgggtg tgagacgtgc cgtggctgcg ctcagtccag 2760

cggggaggag ccgttcagcc cggcctcccc aggaagccat atccccactc acccggtaag 2820

agaaccttgt acgtcccctt tccatgctct cctaggacac gagcccagga accccagacc 2880

cagggggagg aagggtggag gggccccagg ggtcaccatg tgcaccaggg gccgtgaggg 2940

gccggggcat tcagcttcag ctctgaaccg gggaagctgg cacggcaagg actgcctcag 3000

gtgacgggcc gtgagagggg acgggtcagg agccttccca agccttctcc tcagcccgac 3060

acccatggcc atcggaggct aggatgccag acacagccat ttgcagaaat caggcacagt 3120

gactgcagct cacgtccagc caaccaagca tggggccgca gcttcaggaa gtcccttccc 3180

gccacaccac agcctaattc ttactgggac ggaggcaact cgggctacgc tggggcagga 3240

cgacaaacac gagacgccac tgtggaatga gcaacttcgg agcacggggt gacttgcttg 3300

ggaccgtgcc cacgtgacag ccccttatgc agaggaggaa agagaagccc cgagtgggag 3360

gggaacctgt ccaaagtcac acggtgtgtg ggtgacacag ctggggtgag tcgaggctgg 3420

cccctgaggc ccatgctccc tgaacgctgg agaccactgt cggctagcag cggctctcag 3480

ggaaggcctg gtctccaccc tcccagccta gcctcgcgga ccctcgtcct ccccacatcg 3540

gacctgctca cctgcctgga ccctgggctg ccagatgcag gaagcatcaa accccccagc 3600

ctcgtgggtg cggggcaggg cgcaggcagc acagcttaga tgccctggtt tgtccctctt 3660

gtctcctggg aagagcttgc tcccgcccag ctctcctgcc actggccttt cagggttggg 3720

ctgggcccag agtgcctttt agtcgcttct cacggtggcc tgatggctca acccagtccc 3780

aaacgggccc agtgacactg ccgactgcac cccagctcag gcccccactg caccagcaat 3840

gctagaaaac caagccaata aaagtgattt cttttttcat taaaaaaaa 3889

40

gcggccgccg cctgcgcccc cctggactcc ggcgcctccg agaacagccg caagccccct 60

tcggcgtcct cggccccggc cctggcgcga gagtgcgtgg tgtgcgccga gggcgaggtg 120

atggctgcgc tggtcccctg cggccacaac ctcttctgca tggactgcgc cgtccgcatc 180

tgcggcaaga gcgagcccga gtgtcccgcc tgccgcacgc cggccaccca ggccattcat 240

atcttttcct agagcgcggc cccgtatcct tcccaggcgg cgccgccttc tccacggcca 300

gtgtttacag atgagcttta actgccgcct caggcgtgga gacggagacc ccgcagcccg 360

gcggcgcctc agcccttcaa cgacagtatt gagtggtcag gttacaataa accggagaga 420

aaaggtccgc ttgcactttt tttagttttc ttatttttag acacccctcc cctccagggt 480

gatctttaaa aaagcaaaac aaaaaacacg acttttccag cgctcagcgt tttttccttt 540

cgtccgaagc cgttttctga tttgactttt ctcgccggcc ggtctcaggc cgcacagacg 600

ttccagagga ggagggtgac atttttactc cctttttggg gctaaccatt tatgcttttg 660

tacatcaacc gtgcgcggcc ggaggggggc aggggggcgg gggcgagggg cgttccaatc 720

aaatttctaa ctttctgtta attattaatc ccctttttac tgcggtttct gttgtcattt 780

ttaaaatttt tttaattnnt tnttnncgtn taacttttac tttttacctc ttgtgtatat 840

gtagggaatt tatagggaaa tatgtacttt atggaataaa ttttaagaac taaaatatat 900

tttattttaa ataaagtaat ggacctttaa tcttacacag ctaaattact gattatatat 960

ttgctgagct gatttaaggg ttaaaaaaat tgtatcaaga gttttatttt ttgacttcaa 1020

agccttctta ataaagcctc ttttctacat gtgagcaaaa aaaaananna aaanaaa 1077

41

gttctttgat ctatacattt tcattgttta aagtgttcac aggtcaatgc ccatgttacc 60

caaatagcag taagaattat ttatgatgaa atctctcaga tatatctggc gcttagtgtc 120

aaggggtcca agtcatcttg ttgagctgag actctagtgt attttcatag attacaggcg 180

tgagccacca cacctggcct ttctgcaaca tttttttaaa aaaatctaat aaatcttaga 240

tttttaaaaa agaattaaaa tgtgggagtt ctcagaaaga aataaacaca tgagaataag 300

attattacac attttggaag gacttttgag gaatgatgtg atgtgtagag aatagaaaga 360

tttagatata tgcctgtgac aggaatagat tctgggttca ggggtcccca tctgtacaaa 420

tgagaagatt ggattatcta atcttttaga tccttaacaa ctctgatatt ctgagattct 480

ctcatttgta gaatgcccgc tgatgcattg tttatttttt ttgctcataa tataaatatc 540

agattatgtt taggagtgga ttaggtaatt agtgtcacta catgtatcat taaaggtcct 600

aaaaggaatt gttaggcggc aggctttgtg ttacgtgtta catggagtga gggtagatgt 660

gaagatttaa aacgattgat ggatttaagg aagtggtaca taaatatgtc tgttattatg 720

caatcgtagg tcatgataat ttattcagtt atagaaaaca tgccacagaa gccgatgtaa 780

caagtggtgc ttctttagaa agttgtcatt agaatgttct gaggaagtta agcagctgct 840

tcatcaatcc catgacacat gccttgttag catgcccatc aaataatcag atcaaacacc 900

tgctccttat tgccataccc acgaactgtt aaatataaaa aaattcaaag tatttgacat 960

cttaagcaaa tatccagaat atttttaagt aaaaaaccat cttaagtatt caaaatttcc 1020

ttggtttttt aaaggtgata attttgcttt gtgttacttt tttgctcttg aatgtatcgt 1080

tatgatggtc tcttataatc atggtatctt tcacagaata aaaattaaaa ataatgccag 1140

ggtgcaagtg accaaggcct tatcttgaaa gttaaaaaaa aaaagtaaag aaatcacagt 1200

aagttctatt agtgatgata gaaccagata taaaattgtt cagtgatgga gaaaagaaac 1260

gataaatact ttccaaggtt atattgttaa attatcttaa attatcaagg tgtaagatgt 1320

aatgatccca agagttttta tagaatccta aaaaataacg cctgatgtat agattagtta 1380

gcaaattctc agaaatcccc cacataaaag ccttactttg ttcaaaattt attatagtgg 1440

tttaatcatt ttagatttga atgttttaag ataggagaga cttagcagaa aatacttggc 1500

ttgccagggc cacgttctac ttcattgctt tcttttataa gtgcaaggag ttatttccat 1560

cagttgacat agatattatt cactaaaatt ttcagcagac tcaaaataga gaggagactt 1620

taaacttaca tgttagcata aaacagactt ctctctcatt gcatgcacta gatcaatatt 1680

atcatctgta ttaagctatc tgaatttatt cgagacatta agaaaaagac agtacatggt 1740

gggaaagctg cacatttctc acaaggaaaa aaacattcta tatttgtagc agaaatcagt 1800

ggtttgaaaa gtcatacttt gcagatatga acctgaaaat caaagtgcca ttgttaaatc 1860

atcctaaagt gtactgtggg tattctccag catacttgaa aatgaataaa gttagattgc 1920

tcacattgaa gctaatggtt gagacaagac acctgccaga gtgaagtttg attcctatgg 1980

gtgagaagat gtagatgact attgttctca ctaaagttct aaaataatag caagtgtaga 2040

gaagagccgt tgctttgaaa atacatacca catttgttat aaagcatttg tttgttagta 2100

tcaatcacat aggtagaaag agtttgagtt ttactgtgga ttaaaaagcc ttccctaaaa 2160

agagagcatg ccagtcatag agacactaat ttggcacttt tcctccttct taggtttaaa 2220

tgttatacca atgcatgtgt ttgaaatatc cattaagatg atttaaaatt tgtcttgtat 2280

tttgagtttc ttaaatgcgt ggattcttgt tcatttatct ctgaatatgt ctcttttata 2340

ttttggcaca attatacaca ttggaaaggg ccaacctatt agggctcaag tatgtatatg 2400

caaaaaaaaa aagttatatc aaacaggcac agttattaca actagagaga aattccagaa 2460

atatttgttt ttttaagaga aagtaaattt tcacattaga tttctattca aagtactaat 2520

atctacatgg tccacacttt tctattttaa aaaattgtgt tctcttgtta aatagattaa 2580

catttccact tctgtttatc acaaaagact gtatttgaaa tatgcatacg gaaaattgaa 2640

attatattag taataaatgt aacttgaaaa atcaaa 2676

42

cacccttttt gaagtagtct gggcaatgca caaagcagtc catggtggcc ccccagtccc 60

ccaggcttac tacccccctt gttgcagagc ccaaagtcca gctcctcatt cccccatcca 120

ctcttctaac tggggaccca ggactcctgc actgccctgt tcttaccccc tatatcccaa 180

tcacctgtac tgttagcttt caggttctta ttggttcctc cactaaggac gggccatgag 240

ggcagggacc ttatctgccc ttcagggcgg aattcccagt accaggcacg cagtaggtgt 300

tccataaatg tttgctgaat gactaaaagc ccacccccaa ggaacaaaga aaaatctctc 360

ctttcacaca cttcccaggg cctgctcagt gccttgctct ggaaacagag cttggtgagc 420

ttcctgggga gggtctctgc ctagggcacc ttcagctcag gtggtgggtg agccgggctg 480

ggggtgggag cccccgccct caccactgct cctgccccca cccccgcggc tccgtctgtg 540

tgcagtgctg atcctggtcg gcgtgggact ggaggcgacc ccctctccag gtgtctccag 600

cgccatcttc ttcgtgccgg gcttcctgtt gttggtgcct ggagtctatc acgtgatctt 660

catctactgc gcggtcaagg gccaccgggg cttccagttc ttctacctgc cctacttcga 720

gaagtgatcg cggcgcagcg tggacccctt gcgcccatgg gggcgcccct cttgccctgt 780

tccgttcccc tcatctcaag ggaagaggcc ctccaggacc ctcgaaaccc cagcccctag 840

ggagtttgct caggaagttc ggggcatgca ggcctggccc tgggaaagcc gcccgtcgcc 900

tgctctgtgc cttaacttat tctc 924

43

agggtcgtca ttggacaacc gccgcgggcg ccctggtctc tgctacctgt agctgagggt 60

gctgttgatg ggcagcgcgg cgcgctggng aaggctcgtt ctcgcgagan ttcagctccc 120

ttcttanccg tggctgcctc agcacctcga ggatcgacat ggacgctctc gaggactacg 180

tttgggccgc gggcaacctc ggagcttata ctcctcccag tgacgggtct ggagtgcgtg 240

ggggaccggc tgttggcggg tgagggtccc gatgtcctgg tgtacagctt ggactttggt 300

gggcatctgc ggatgataaa gcgagtgcag aacctgcttg gccactatct tatccatggc 360

ttccgggtac ggccagagcc taatggagac cttgacttgg aggccatggt ggctgtgttt 420

ggaagcaagg gactccgagt tgtgaaaatt agctggggac agggccactt ctgggagctt 480

tggcgctctg gcctgtggaa catgtctgac tggatttggg atgcacgctg gcttgaggga 540

aatatagcct tggccctggg ccacaactca gtggtgctat atgaccctgt agtagggtgc 600

atcctgcaag angtgccctg cacagacagg tgcaccctct cttcagcctg cctgattgga 660

gacgcctgga aggagctgac catagtggca ggtgctgttt ccaaccagct cttggtctgg 720

tacccagcaa ctgccttagc agacaacaaa cctgtagcac ctgaccgacg aatcagtggg 780

catgtgggca tcatcttcag catgtcatac ctggaaagca agggattgct ggctacagct 840

ttcagaagac cgaagcgttc gtatctggaa ggtgggcgac ctgcgagtgc ctgggggtcg 900

ggtgcagaat attgggcact gctttgggca cagcgcccgt gtgtggcagg tcaagcttct 960

agagaattac cttatcagtg caggagagga ttgtgtctgc ttggtgtgga gccatgaagg 1020

tgagatcctc caggcctttc ggggacacca gggacgtggg atccgggcca tagctgccca 1080

tgagaggcag gcctgggtga tcactggggg tgatgactca ggcattcggc tgtggcactt 1140

ggtagggcgt gggtaccggg gattgggggt ctcggctctc tgcttcaagt cccgtagtag 1200

gccaggtaca ctcaaggctg tgactctggc tggctcttgg cgactgctgg cagtgactga 1260

tacaggggcc ctgtatctct atgacgtcga ggtcaagtgc tgggagcagc tgctagagga 1320

taaacatttc cagtcctact gcctgctgga ggcagctcct ggtcccgagg gcttcggatt 1380

gtgtgctatg gccaatgggg aaggtcgtgt caaggttgtt ccccatgcaa cacttccaac 1440

tgctgctgtg gaccagaccc tgtttcctgg gaaggtgcac agcttgagct gggccctgcg 1500

tggttatgag gagctcctgt tgctggcatc gggccctggc ggggtagtag cttgcctaga 1560

gatctcagcc gcaccctctg gcaaggccat ctttgtcaag gaacgttgtc ggtacctgct 1620

gcccccaagc aagcagagat ggcacacatg cagtgccttc ctacccccag gtgacttcct 1680

ggtgtgtggt gaccgccggg gctctgtgct gctattcccc tccagaccag gtctgctcaa 1740

ggaccctggg gtgggaggca aggctcgggc tggtgctggg gcacctgtag tgggtagtgg 1800

tagtagtggg ggtgggaatg ctttcactgg gttgggccca gtgtctaccc tgccctctct 1860

gcacgggaag cagggtgtga cctcagtcac atgccatggt ggctatgtgt ataccacagg 1920

gcgtgatgga gcctactacc agctgtttgt acgagacggc cagctccagc cagtcctaag 1980

gcagaagtcc tgtcgaggca tgaactggct agctgggctc cgtatagtgc ccgatgggag 2040

catggttatc ctgggtttcc atgccaatga gtttgtggtg tggaaccctc ggtcacacga 2100

gaagctgcac atcgtcaact gtggtggagg gcaccgttcg tgggcattct ctgatactga 2160

ggcggccatg gcctttgctt acctcaagga tggggatgtc atgctgtaca gggctctggg 2220

tggctgcacc cggccacacg tgattctccg ggagggtctg catggccgtg agatcacttg 2280

tgtaaagcgt gtgggcacca ttaccctggg gcctgaatat ggagtgccca gcttcatgca 2340

gcctgatgac ctggagcctg gcagtgaggg gcccgacttg actgacattg tgatcacatg 2400

tagtgaggac actactgtct gtgtcctagc actccctaca accacaggct cagcccacgc 2460

actcacagct gtttgtaacc atatctccct cggtacgtgc tgtggctgtg tgggggcatt 2520

ggcaccccag gtggccctca ggatcctcag ccaggcctga ctgcccatgt ggtgtctgcg 2580

ggggggcggg ctgagatgca ctgcttcagc atcatggtta ctccggaccc cagcacccca 2640

aagccgcctc gcctgccatg tcatgcacct ttcgtcccac cggctagatg agtattggga 2700

ccggcaacgc aattcggcat cggatggtta aggtagaccc agagaccagg taatatatgc 2760

tcctgggcag ggtgtggtat gggtcatgca gatgctccca ggcttgcagg ctccacctga 2820

cagctgcatg ttgtctctgc aggtacatgt cccttgctgt gtgtgaactt gaccagcccg 2880

gccttggccc ccttgtggct gcagcctgta gtgatggggc cgtaaggtga gagcataggg 2940

cccagtggga caggagacaa aggaagtaag gttgtctagg atgcgttctg agctgggcca 3000

ccccccgccc cccaggctct ttcttttgca ggattctggg cggattctgc agctccttgc 3060

tgaaaccttc caccataagc gatgtgtcct caaggtccac tcctttacac acgaggcacc 3120

caaccagagg cggtgagagg ggctggatga tggtcctgca tgggctgggt tggggggttc 3180

ctgttgagct tcatctctgt tattgaccag gctgtctttt cctggctctc aggaggtcct 3240

cctgtgcagc gcactaactg atggcagctg gcttctggga 3280

44

ctcttttcca ggcacattgt aaactgtgtc tacagtttat ccatataact tctcttctga 60

aaactgagga gtgtcctctg ttcttccagt tcacgagggc agggggttta aaacaagaat 120

gataggccag gaaggcagtg gggatccacc atcacatgga actgtaaggc catataacta 180

cacaaaactg accaatctgg gttgccaaag cagccaggct tatgctgaaa ccggggaagt 240

ctgacatatg caggaaactc ttttgaaata actttggtgc ccaggccaag tagaatgaga 300

tgagactgag tttggcctct ggctcggttt cctttctttg gtctgatact tcatgtattt 360

gaatatagtt aaatcgtatt atttttttct taacagaaat atttttaaaa atgaaaaagt 420

actcaaaagt gagaagagtt aacttgtcaa agcagaatgg ttctctttga cccactctgg 480

tctattgtgt aaatatttat ttagactatt ttaataatac atattattta ccccactgta 540

acatcatgta aactaagtat gtttttaaac aatttttaag acttgtaatt accctgaaaa 600

taaggtttat aatgcaaaga ccagctcctt tgcggtggca gtgctctagg gctgccatta 660

cacggtcttg tgatgtgact aaaagccact ttgtgactcc cttcatgtaa tcctcttttc 720

ctccccactc ctccacagag ggcagagctc aggacatttg ccagttccag atctcttttt 780

cagcattttg atggaattaa tttacacgta atgagggaag tcctaggatg gatagaaaaa 840

aagcacttac attggggcac acaggaaatc ccagtgtcta gcaatggttt ggtttgcaga 900

gaacacagcc tgatacttaa ttttcttaaa actattttta atgatccact aaacaaagca 960

ggggatcctg aagctgatat aaataagtct agctctataa tccccaagtt ctaaaagtta 1020

tggttagatg ctattctgtg ggttgctttg ataattctta ctaacacaga ttagggtata 1080

ggcatctaga gatgcactgt ccactgtaaa tactataatg agagccacat ctgtaattta 1140

aatgtttcta gtaaccacat ttttttaaaa gtaaaaagaa cccaggtatt gatttaaata 1200

tatttattta acccaatagg ctcaaaaaca ctatcatttc aacataggat caatataaaa 1260

attattaatg agttatttta ctttttttca tattaggcct ttgaaattca gtgtgtatta 1320

aacacatctc aattcaaacc atcaccatat ttcaagtctt tgtagccaaa tgtgactagt 1380

ggctaccata ttagacagtg cagatctata ctcattcctt caaatacatt actctgttaa 1440

tctcaaagtg tggccaactc ccatttactt agaggctgat tatctagttt tgtagttcct 1500

caggcctcta atttattttt tgctttctgc tttattgatc ttttgcatgt cccccaaagc 1560

cagaatctgc tcatggagga aggaaggcta agaactgtcc ttgaggaact tcatcagtaa 1620

ctctggtaaa gcatcctgtg gagggagagg agagcccagt catttgctta gatggtgttt 1680

gtgggatcac ctggcagatt taaagcctac tctgccacag actcgagtaa gaaaatgttc 1740

tcttgatgac acagtgctcc tactctatcc acattaagta ggcacttttg tggtagaact 1800

gattcttaag gcaggcctga aaggccattt actaatagaa acacagcctt tccaatcctc 1860

tggaacatat tctgtctggg tttttaatgt ctgtggaaaa aaactaaaca agtctctgtc 1920

tcagttaaga gaaatctatt ggtctgaagg tttctgaacc tctttctggt tctcagcaga 1980

agtaactgaa gtagatcagg aaggggctgc ctcaggaaaa ttcctagatc ctaggaattc 2040

agtgagaccc tgggaaggac cagcatgcta atcagtgtca gtgaatccac agtctttact 2100

tcctgcctca taaagggcca ggtctcccca gtaccaagtc ctttcctcat gaagttgtgt 2160

tgcctcaggc tgtttaggga ccattgcctg tcttggtcac atgagtctgt ctccttactt 2220

tagtccctgg gcaatccttg cttaatgctt ttgttgactc aacgagggcc cgaggcctta 2280

ggttttctat taaggtctct gccccaggca tggtgctcta tatcttggcc aaataaatta 2340

ctttccttga atatccagga atcttttagt ctaaagcaat gaggagttat cacctcatcc 2400

tcaaactcca acaagatcta tgccttagtg ttgtttttgt tgtctgcttt gatgtaaaag 2460

caagagtatt tggagcaaga agctgcaatg cgccaaatac acaataggcc ttttctttat 2520

cattcatacg acatttctgg tttaggtgta tgtagttggg ccatgttact tgtccagagg 2580

aagagactaa agatataaga ataatttttt agtcctaaat gctgttttgt ttactttctg 2640

tcaagatatt tacccgtgtc aaattcaaac tacagtactg tgtaattatg tataaagttt 2700

ttttatttat ttgaagttag actagatata cgtttttaaa tttaacatct ggctggacag 2760

tgttctatta actcattgaa tgtgtttcct ttgtcttgtg ttaataaata ttgatgcctg 2820

a 2821

45

agcgcttcag ttgtcactgc agagccatcg tatgtcagtt gcaatttcca tctgaagcta 60

tgtctttgac ttcactttaa gcagaaaatt ttgtaccctg gtggtcgagt cttcccttaa 120

aaattgttaa atcatttggc tttaatggtt caataatttg gggtggcttc atggtgtttc 180

ttttcttccc agtttaaaaa aaaaactttt taagcgtaaa atctttaagg ggtacacatt 240

tataagtctg gctaatttct aatatgctaa ttaaacattt cccattttaa ggttatatac 300

agtgaggctc ttcaggacaa ttattttctg ggttgattgg gcatatgttt gccgtgtaaa 360

catggatatg ataaagtgtc agtaacaatg gaaaaggtcc cagaggcatt aggcatctaa 420

gaggatgccc tcagaaacgt attctggctt gatttgtgtt attaacttca gaagaacctt 480

ttcaaatgtc ccagtatcgt tcttagtgct ttgggaaaaa atatttaaca cactgttaat 540

aaatttgtta tcagaagttt acaagacgaa gggcttctct cgtctgaatt tctagattta 600

agtcatgaag tgtaaaactg tttcacccag aagtgtaact aagcagaact aggagttttc 660

tctggcttca cctttttcag agccagcagt gctgttttct caagcacagc gtttgctctt 720

agactctgat ctgcttgtgc ctaagcattg cacaggtttc cgaagacggg cagcttcaga 780

gaagaggatt attcgggaga ttgctggtgt ggcccataga ctctttggca tagactcttt 840

cgcaggcagc cactctgagt gtggccagtt ctataaccat ccccaaacta gctggagcct 900

gatggatagg aacgggtagt ctgtcctctt ccccataaaa atgttccaaa aagttatctc 960

cagagagagt cccttatgaa gacagttgcc aagctgtatt ctcattcttt aaaccaatac 1020

ccaggtcagg gctagttcac actagcactg ttagggacat ggtgtggcta gaaatgaatt 1080

gagtgtgact tctccctaca accccaggcc cagggatagg aggaggcaga ggggtgcctg 1140

gagtttctgc actctcatca gtgatgttca tgttacactt gcacaagggc tgatttccac 1200

gtatgtgtgt gttaatttat tcacttagtt tcaaaagatt ttctctcccc agccattcag 1260

aggtttccaa actaagccac tgagtttgag tcagggaatt ccacgtaaaa agatcagatt 1320

aaggtaaatt ctttgttctg tattgctgct gtgacttcag aaaaaaaaaa ttatgagagc 1380

tcttcctgga attttgaaat ttctatttaa tgaagaagtg tataattcca ttatttattg 1440

tttgaggttt gatttatctg gaagcttaaa aagaatgttt tatttttgtt gttaataaaa 1500

tcccaatcac atttcacaat aactaaaatg tctccaggtg ggttactggt agatgatagt 1560

ggtgacacct gcaggtctgc atttgaattg gattcacaga gaagcattcc atggtcacat 1620

aatgaatagg gagaacagat attttcagaa aaatcaaccg attgtttttt ccagaaacag 1680

aacagaaaat gttcagaata ttttcaaatt tgtcagattc ttttatgttt cctttgaaat 1740

ttattattta agcctattac taaaccttta taaaaatata tttggcaaat acaccaaaga 1800

aaccagctta caaaagatta tgatcattaa tgaactgcaa acctcatctt tcgaaaacaa 1860

ggttttgngt ntttttattt tttgtaaata tttgtgttta taaatgtaca gcagagtaag 1920

agtgtttttt agattattta attcccatat ttctaaacta tttactacac agtaatccat 1980

gcctgttagt ttggaggact tgactgtctc attttttaat tcattgtcag tcatgcttgg 2040

aacagcattt ccactagaga atccagcgtt ctggcagtag caagagtaca catctggagc 2100

atgagggact ctagcatgac tcgtcagatg cacaccccaa gagacaagaa tgtgtagttt 2160

aatgaccggc gtggaccata cgaaattgag attctaactt tcctgcagga gtgctcatga 2220

gcccagaatg tgattgggat aaggccattt gcccacaaat ttagctttca tgtaactcct 2280

agtgtgttat atcataatgt attttgttct tcctttttaa tgtaagtttt gctttgggtc 2340

aatttgaatt aaaaaaatca aatctga 2367

46

ggagagaggc agtacctgcc gtcagggatg gagcacagca tgcacatgat tagcccttca 60

cccaataacc aacaggcaac caacacttgt gatggccggc agtatggggc agttccaggc 120

tcctcctccc agatgtccgt gcacatggtt taaaggccag tccaaacacc acggagcatt 180

tggcaatcaa ggccccagag tctccgtggt cagatcctcc tctttgggag tcacccaaga 240

acaagagata cctttaagcc agtgaaggat acttgcgata gaatcatccg caactcagtg 300

gccattcttc tgccttccca gaccttattg tctgttccag agtggccttt gaagagactg 360

aataatcact tcgtcataat gttaagggag atgctagtgt gtggcagcca nnnnnnnnnn 420

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnta 480

ttcatacaca attcatacac atgcaatcat acatgcacac tgactctgaa ctgggtgaac 540

tctgtggagg gaggcccaga atgggtgctt tcaccaagaa tttgtctgtg tacaactcta 600

gatggagtgg gccagcagta gctgccagtc tttctcccct gcagcttcct ctgcttctgg 660

aatgaaccat gtatcctgga gaccctccca atggatgaga gtggaaagac atcagtacaa 720

ctggacttgg cttccggaaa aagattgctt ttgaactttg gctctcttca cttgtatgct 780

atcattgata ttcccagtgg tgcccgtgga aagagggaga aagagaagct gaacaggaga 840

aagacaaaca gaaagaatag agaacaggaa cgaggtggag agcaagactg acagagaaag 900

tgtgagcaat gatgagaatt ttaattcacc aaggagacgt gtttttggtt tgtcccccca 960

aaccccgccc gccccactac aggttatgga aagaatcatg gcattactga ggagtaaacc 1020

tctctggcac actgagcatg gtcagggcat tggtcagagg gacagagcaa ggaatgcatc 1080

ctgagcccac agctttgacc actgtgatcc agaagagagg tgcactacgt gggaagtgct 1140

gattccacag catgcagcct ggtaggggaa ggaaaataaa agggtgtgaa gaaggaatag 1200

ttttataatc tcggaagatg ataccaagag cagaggcaac aaatagaggc ctggcctcca 1260

ggtgccggat ccagacacct gacctagaat gcctgcccgc tatccctgtg gcaggaaata 1320

tcccctcatg tcccagggaa ttgcagatgg gtcttctata cccttctacc tgcccttaga 1380

tctccatttt tatcaaatag tacattgcat tttgaagttt tgggttttgt ccttcatctt 1440

tccctttccc ttcaaatctt ttaatggtaa gaaagcaagt gaagcttggt gcaagctaaa 1500

atttttaaat ggtgtggaaa tgcaaataat accaagtaaa ataatacaga tattattaaa 1560

gtttctggtt ttgaggtgtt gtagataaat gtatttatgt gcctagtggg gaatccaata 1620

ttatgaatat gaaaaagggg gcaataaaag ggtatgtaaa atatgtatga agaaaaggtg 1680

tacaaaaatt tgcccttatg cacggaactc tgtttctaag tgccaagcac agaaagccgc 1740

taaataaaat ctttgcaatt gttttctgc 1769

47

cgaactcagg gtggcagccc ggagccgggg aatgtgaaga gctctcggct gtgcagtggt 60

accgtcgggg cctgggccgc gaaggatctt ctgccacagc tgcaacatgg gcggcaagaa 120

caagaaacac aaggctccag ggagccccgt gtcaagcaag gtccaaaaat ttatagtttt 180

aattctacaa atgattctag tggtcctgca aatctggata aatctatttt gaaagtggta 240

acttaataac aaactagagc aaagaattat tggagtgatc aatgagcata aaaagcaaaa 300

taatgacaaa ggaatgattt ctggaagact tactgccaaa aaattgcagg atttatacat 360

ggctttacaa gcattttcat ttaagacaaa ggacattgaa gatgccatga ccaatacact 420

cttatatgga ggtgaccttc attctgcctt ggattggctc tgtttaaacc tttcagatga 480

tgcacttcct gaaggattca gtcaggaatt tgaagagcag caacctaaaa gtaggcctaa 540

atttcagtct cctcaaatac aagccactat ttcacctcca ttgcaaccta aaacaaaaac 600

atatgaagag gaccctaaga gtaagccaaa aaaggaagaa aaaaatatgg aagtaaatat 660

gaaagagtgg attttacgat atgctgaaca acaaaatgaa gaagaaaaga atgagaattc 720

taaaagttta gaagaggagg aaaaatttga ccctaatgaa aggtacttac atcttgcagc 780

aaaactgctg gatgcaaaag aacaagcagc tacctttaaa ctagaaaaaa acaagcaagg 840

ccaaaaagag gctcaggaaa aaataaggaa atttcaaaga gaaatggaaa ctttagaaga 900

ccatccagta tttaacccag ccatgaagat ttcacatcaa caaaatgaaa ggaaaaagcc 960

tcctgtagcc acagaaggag aaagtgcatt gaattttaat ttatttgaaa aatctgcagc 1020

tgctactgaa gaagagaaag ataaaaagaa agaacctcat gatgtaagaa attttgacta 1080

tactgctcga agttggactg gaaaatctcc caaacaattt ctgattgatt gggtcaggaa 1140

gaatcttccc aagagtccaa atccttcctt tgaaaaagtt ccagtaggta gatactggaa 1200

atgtagggtt agggtaatca agtctgaaga tgatgtcctg gtagtatgcc ctacaatctt 1260

aacagaagat ggcatgcaag ctcagcacct gggagctact ttagccctta ccgtttagtt 1320

aaagggcagg taagactttt taggcctaac tatatctgta tgtggaaggc agtatttaat 1380

tatggttcaa ttttctcttt attgaactgt ttcttctgat aat 1423

48

agctgctgtc cttccaccac cagcaccgga ccacctgctc caagaccagc ctcctggggg 60

gaccaggcac ccggccttca ctggcaccca gggagccgtc ctcagcagcg tcaacatgtc 120

aaggcccagc agcagagcca tttacttgca ccggaaggag tactcccaga acctcacctc 180

agagcccacc ctcctgcagc acagggtgga gcacttgatg acatgcaagc aggggagtca 240

gagagtccag gggcccgagg atgccttgca gaagctgttc gagatggatg cacagggccg 300

ggtgtggagc caagacttga tcctgcaggt cagggacggc tggctgcagc tgctggacat 360

tgagaccaag gaggagctgg actcttaccg cctagacagc atccaggcca tgaatgtggc 420

gctcaacaca tgttcctaca actccatcct gtccatcacc gtgcaggagc cgggcctgcc 480

aggcactagc actctgctct tccagtgcca ggaagtgggg gcagagcgac tgaagaccag 540

cctgcagaag gctctggagg aagagctgga gcaaagacct cgacttggag gccttcagcc 600

aggccaggac agatggaggg ggcctgctat ggaaaggccg ctccctatgg agcaggcacg 660

ctatctggag ccggggatcc ctccagaaca gccccaccag aggaccctag agcacagcct 720

cccaccatcc ccaaggcccc tgccacgcca caccagtgcc cgagaaccaa gtgcctttac 780

tctgcctcct ccaaggcggt cctcttcccc cgaggaccca gagagggacg aggaagtgct 840

gaaccatgtc ctaagggaca ttgagctgtt catgggaaag ctggagaagg cccaggcaaa 900

gaccagcagg aagaagaaat ttgggaaaaa aaacaaggac cagggaggtc tcacccaggc 960

acagtacatt gactgcttcc agaagatcaa gcacagcttc aacctcctgg gaaggctggc 1020

cacctggctg aaggagacaa gtgcccctga gctcgtacac atcctcttca agtccctgaa 1080

cttcatcctg gccaggtgcc ctgaggctgg cctagcagcc caagtgatct cacccctcct 1140

cacccctaaa gctatcaacc tgctacagtc ctgtctaagc tcacctgaga gtaacctttg 1200

gatggggttg ggcccagcct ggaccactag ccgggccgac tggacaggcg atgagcccct 1260

gccctaccaa cccacattct cggatgactg gcaacttcca gagccctcca gccaagcacc 1320

cttaggatac caggaccctg tttcccttcg gccctccagc cccaaacctg cccagccagc 1380

cctgaaaatg caagtcttgt acgagtttga agctaggaac ccacgggaac tgactgtggt 1440

ccagggagag aagctggagg ttctggacca cagcaagcgg tggtggctgg tgaagaatga 1500

ggcgggacgg agcggctaca ttccaagcaa natcctggag ccctaaaagc cggggacccc 1560

tgggacccan ggccagtcac ctcttgggtt caatgcttcg cttagctcga ggcctgaaga 1620

ggtcacagac tggctgaagc agagaantct t 1651

49

gagagagana gagagaaaga ggtttttaaa ttctccatga agtgtactat gttccatcat 60

tccttcccaa agccaccgga agcattcctt ctaggaaagg tggagtcggt agtgagaagc 120

cggaggtgag aagacccctg agcggatgga ttcattcatt ttctgaattt cctatgtgag 180

gacagtatta gagcccagtg aggctttgag aggccccaaa gatgagcgcc aacagtagca 240

gagtgggcca gcttctcttg cagggttcag cgtgcattag gtggaagcag gatgtggaag 300

gggctatcta ccacctagcc aactgcctct tactcctggg cttcatgggg ggcagtgggg 360

tgtatggatg cttctatctt tttggcttcc tgagtgcagg ttacctgtgc tgcgtgctgt 420

ggggctggtt cagtgcctgt ggcctggaca ttgttctttg gagcttcctg ctggctgtgg 480

tctgcctgct ccagctggca cacctggtat accgtctgcg tgaggacacc ctccctgagg 540

agtttgacct cctctacaag acgctgtgcc tgccccttgc aggtgcccct acagacatac 600

aaggagattg ttcactgctg tgaggagcag gtcttaactc tggccactga acagacctat 660

gctgtggagg gtgagacacc catcaaccgc ctgtccctgc tgctctctgg ccgggttcgt 720

gtgagccagg atgggcagtt tctgcactac atctttccat accagttcat ggactctcct 780

gagtgggaat cactacagcc ttctgaggag ggggtgttcc aggtcactct gactgctgag 840

acctcatgta gctacatttc ctggccccgg aaaagtctcc atcttcttct gaccaaagag 900

cgatacatct cctgcctctt ctcggctctg ctgggatatg acatctcgga gaagctctac 960

actctcaatg acaagctctt tgctaagttt gggctgcgct ttgacatccg ccttcccagc 1020

ctctaccatg tcctgggtcc cactgctgca gatgctggac cagagtccga gaagggtgat 1080

gaggaagtct gtgagccagc tgtgtcccct cctcaggcca cacccacctc tctccagcaa 1140

acaccccctt gttctacccc tccagctacc accaactttc ctgcacctcc tacccgggcc 1200

aggttgtcca ggccagacag tggcatactg gcttctagaa ttcctctcca gagctactct 1260

caagttatat ccaggggaca ggcccctttg gctccaaccc acacgcctga actttaagga 1320

tcattggact atcttctctg tggccagcgc agctctcttc tgtgttcaca gaatggccac 1380

tgataggcac gcctcttttc ccacccactg gaa 1413

50

atttactatt nattaaatgg aagtgggtca acataaaagt cttcattctn attgtcttca 60

cattgagtag gcagaggagg agaaagatgg ggaggaagag aaggcgttgg tcttgcagtc 120

ttgtcttagg ggtgtgggga gtgggggaaa gaatattcat gtataagtgg gaccccttgc 180

nattccaagc ccttgttgtt caagggtcaa ctgtaatagg atatagctat ttttcttcct 240

ctatcaacca aatggtaagc atctattttg tagtccactc tactgagcta aattatagat 300

ccagctatgc tatttataat tattttcttg atgaataaat tttcaatttc tcctctgacc 360

atttcagaac atcttccaat aactcataaa acaactgaag taaaattgag tgctggaaaa 420

tatattcacc aaactttggt aatttaagtt gactaaagtt taaaattaag tctaaaatag 480

tttacaccta tactgcataa tccaacaatt ttaatttcag ttgaagacat gttactaata 540

taactattat taaaagagta gaggatgtgt aattaaccat atcttctaaa acatggttac 600

taaaagaata tgtaacatca atattgacct tggtttctta cacaagtgtt gctaactcaa 660

tagtgaagga gacactatta aattttctga acccatgaga gatactagag atggggagtg 720

gaaagtgttt ggttcaggga tatctgaaga acagaagggc agagatttct taagtgacgc 780

ctcatctaca agctggaaat tcctaaaaac aagtagaaag cttataaaca acaggtgata 840

cactcacctc actggtttta gtaaattacc aatacagaaa gtatccctag tcttaaaaac 900

aagtggaaaa tttgaactga ttagtcatat tcctttgatt acactgtttg ttacaatatt 960

tttctcagta aacagaaata actaattttt ttgttcttca ttctttgata gaaattaaaa 1020

tcttattctg tgaggattac agaatactat aactcaaatt ataaagtaga ataaactctt 1080

taaataatta ttcttcatca taaagtgtaa agaataagat ataagaaaac aatttatttt 1140

taaaatttaa tatactaaat gctcaaatat gttctactat agaataagtt cttatcttaa 1200

tttacagggc actaaaaaca attttaaaat gcttaatgtt gccttttata ttttaattgg 1260

ttaagaatat atatttgttt aatgcaaatc agaatcacta tattaaaatg aatgttcttg 1320

51

tcgcggccgc aggagccggc gccgggcggc tggggagggc ttgctgacgc tgcgggccaa 60

gccgccctcg gaggccgagt acaccgacgt gctgcagaag atcaagtacg ccttcagcct 120

gctggcccgg ctgcgcggca acatcgccga cccctcctct ccggagctgt tgcacttcct 180

tttcgggcct ctgcagatga ttgtgaacac gtcggggggg ccggagttcg cgagcagtgt 240

gcggcggccg catctgacat cggatgccgt ggcgctgctg cgggacaacg tcactccacg 300

tgaaaacgag ctctggacct cgctggggga ctcgtggacc cgccccgggc tggagctgtc 360

cccggaggag ggacccccat acagacccga gttcttcagc ggctgggagc cgccggtcac 420

tgacccgcag agccgcgcct gggaggaccc agttgagaaa cagctacagc acgagcggag 480

gcgccggcag caaagcgccc ccgaggtcgc tgtcaatggt caccgaggac ttgggagcca 540

gaatctgagc ctcagctgga gtcagagaca gcaggaaaat gggtcctgtg taattatgac 600

ttccaggccc gcaacagcag tgagctgtcg gtcaagcagc gggacgtact ggaggtcctg 660

gatgacagtc gtaagtggtg gaaggttcgg gacccagcgg ggcaggaggg atatgtgccc 720

tacaacatcc tgacacccta ccccggaccc cggctgcacc acagccaaag ccctgcccgc 780

agcctgaaca gcactcctcc tccaccacca gccccagccc cggccccacc tccagctctg 840

gctcggcccc gctgggacag gccccgctgg gacagctgcg atanctcaac ggcttggacc 900

ccagcgagaa ggagaaattc tcccagatgc tcatcgtcaa cgaggaactg caggcgcgcc 960

tggcccaggg ccgctcggga ccgagccgcg cagtcccagg gccccgcgcc ccggaaccgc 1020

agctcagccc gggctcggac gcctccgang tccgcgcctg gctgcaggnc aagggcttta 1080

gctccgggac cgtggacgcg ctgggtgtgc tgaccggggc gcacttttct cgctgcagaa 1140

ggaggagctg cgggcggtga gccccgagga gggggcacgt gtgtacagcc aggtcaccgt 1200

gcagcgcttc gctgctggag gacaaagaga aagtgtcaga gctggaggca gtgatggaga 1260

agcaaaagaa gaaggtggaa ggcgaggtgg aaatggaggt catttgacct gccaggcgcc 1320

cttcgcaaag agtgacgagg ccccgtggga gaacggactc ctcagactct ccccaatagc 1380

ggaagtcgat cttctgaagg atggccaatc tgctccggcc ctggtcttcc cccatcccgg 1440

tggacagact taacgatcct tgctgcagtc cctccggaga ggatctggac tggctgggag 1500

tggggagggc gtggagacag tctacggaaa gcgctagcag acccccgaga gggtgcagtg 1560

gagccctgag cattgtaata tgcggcccag cctataaaca gcctccgtgc ttagcagatg 1620

gtgtgccant tnaaa 1635

52

ttttcaaaca caaagtggat ggtggtatga gacaatgttt aatgtccttc taactccgag 60

agtccttgat tctggagagg cacaggatga acatctgttg ctactgctga gtatacacac 120

tcttgcctct gagatggcgt gaccagcaga aaagaaagct cagggctgtg gcttcagaat 180

tcatggaaac agagccactg tcaagaagga atctgctcag agcagattct gagttttcac 240

actccacaaa tcctcagatt tagtgggaag ctggaaaaag gaactcttaa ttccaattga 300

ggagaaacaa gaaaacatta caaatcagtt tcccaagctg agaaggatta gccttgaccc 360

cttgggtctg cctctgttgc cctcaccagt ttaccttcta caacagtttc tcaggaacat 420

gtgtatttcc ccattcagct ttcagcattg ctccacgcca cagcataagc atagatccca 480

agtccacagg ctccattttg caggtcatct tctgatccta gcaaatgtcc tttccccata 540

gttgtcctat gcctttgggc tttagtctat cccaggacta actgtggaga aatcattggt 600

ttgagagtca agagagcatt ggtttgggag ctttaatcct ctttctgctt cacactaagt 660

gtgtcatctt ggctaaatca cttggtcttt ctgcattttg ttttcttatt tataggatga 720

ggaaattaga ttaaatggtt ttgaggtcct ttcttgttct gatatgtcca gtactcactg 780

gaaaattgga tctataactg atgggtttag taatctgctc atttcttgct ctgaaaattg 840

tagtcagcaa aagagatcat ggaagaaatc actgtaatgg tagtaatagt aacacatgcc 900

atttgtattg tgccttaggt ttaccaggtg tttccaaata cattagcata tttgatatgt 960

gcaggactag ataccttggg acctgccaca ctccactttc aagatatgta ttagcttcat 1020

tagaattaaa gggacttgaa ctcaggacct gcagcctatt ctttatccac atgtctctgg 1080

tagggctaca tccagatcac accatgactt cttatagagc aagagaaaat aatattatta 1140

tatcttcctt tgcctaaaat ctctccactt attctttttt atgattctgc accagttcac 1200

tgggttattc tatgattcca nnnnnnnnnn nnnnnnnntc atatttaaaa tgaacttaca 1260

atgtctgaat tttcctggcc ttgagtcaca gaagtaatat gtttcagatg gctgcccaat 1320

atgtattatc atgtaataca tatctgtgtc cttttctggg atgaggaagg cttcaacttc 1380

tggcactgag aactttgtat tacagacaca ggtttagttt ctagcttagt catgccttta 1440

gagtttagta gcacaaatcc atgcaaccca acagaataca tggtgagggc ctagtatgta 1500

gaatttgaaa gtagttcaaa tttgaattag aagaatgaag ctaggactta tttggaaaag 1560

gagatagaaa aaaaatgatc agaaactgtg gggccttatt acctttgcag taagttatct 1620

tcttcatgat atatgtgaat tattttatgt gcagattgtg ttttgggatt gtcagatcta 1680

aacttatatt cttgctggct aatgtgctga tagccaggtc tgaaacttga tgtgctatcc 1740

agacacatat gatcagaaaa gatctagagt gcaaagaggt gtctgaggag caaaatgtgg 1800

ttttaatgtt gtggaaagat cacttgcaag tatataagac tgtataaaga agaggactgt 1860

gtgcaagtgg ggtgaaaaaa aaggatacgc gaatgtgcat atgactgaat agggaggaag 1920

gtcagggcta gaaaggaggc tacataaaaa ggggcaatgg agagtgcaca ggaaagacac 1980

aggggaaggt caagtcgagc aaggtagaaa caggagtagc tagagccatt gggaatccat 2040

tttgaaacaa gaaggagttt tgaaagggaa taggaaagta agtgtcttga agtaaaagat 2100

aaatatggat ggagaaagaa gaaattctgg atgatagaga tgataaaaat atttattaag 2160

aaatgaagtc aggttcagtg tatgaaatgg aaaggaattt ttcagaattt taagaaaggg 2220

gaagttcctc ttggaaaaga tatagcaacc attggggaat gaccttttca tttcagaagt 2280

ggatgaggaa ggtggtgtga gcatcaggta tattctggac catttcaagt gctggtgaga 2340

agaaaggaac tctttgcctg aactgggctt ggttttccaa gtgctgcttt ggaaatgaag 2400

acccagagat gcagagctta tggtagttca taaatcttca tgttctatta tctttcatct 2460

gccaataaag ttcattttca ataatgtcca ccattgctgt gcccagaata accacaggca 2520

aacatcaaaa caatacgcat aagttagaca agattaaatc ttgtctgata tctgcacaaa 2580

cagatatgca ccatgttgga aacatgtgtt ttcctagtcc catccaggct tcccacaaga 2640

aagccatgat gtgggtctaa accatatgtt ttgagtaaag gagaatagaa gaaggggagt 2700

gtccgcaaaa tggaaagaga tgaagatgtt ccaaggaaat atgctgaaac agaacagtga 2760

atgttttgcc caaaactaca aaaataaaag aaaaaaagaa aattgcaata catggctact 2820

aagtctttga tcataagtcg aatttataga cctggaattt gccatcctag tctttccttt 2880

ttagtaagac ttctgtcctc tggcagtgca tatggtaggt ctctaatgtt tctgcatctc 2940

caggaagatg cagatcctta tttttgctgg gaaatccttc taaatagaaa tgtaacattt 3000

ttataaaaac agattaatgt gtttttcact tagtaaatgt tttcaagagc tgaattgaga 3060

aggaaagaga ctggagtggt taatggtgat ttgatttctg gcattctgag ttttctgcta 3120

caattagctg cattacttgg tgccaaagag cagtggggaa ttgttgagtt gctgtatcct 3180

ttaaaaaaaa acaaaaaact tgttattttg aaagaactta aggctcacaa gatgttacaa 3240

aaatagtaga gtggccttac cctagatcca gttttcccca tttataacat ttcacttagt 3300

ccattttcgg aaccagaaaa ttaacattgg cataatgcta taactaaact acagaccttt 3360

ttcanttcgc cagtttttcc acacatattc atttagttgc tggatacttt taattcttgc 3420

tgatttgtaa actggccttg cttggataca acaggaaaga tactatctgg ataaagttct 3480

acagttttag agagactatt aacacattaa tgtgttcctt tgtgcatgag caataccctg 3540

cctacactgc ttctaaattt tctgatttgt ttggctgttt ggcatctgaa acaatccaag 3600

acaaacttag aaagattagg caacacaaaa cacagtaaga cctgttcata gcttgttgcc 3660

tagaaaacca ggtagcagga tattctagat gcttcctgct gcttctacgt gagtaggatt 3720

agcactgggg acaaaataag gagtttagag taaaccagta tttcagtcaa gagttagttg 3780

gcacttagtt aatggcactg gaaatagctt gtggagagaa tagaatacaa tggtatagac 3840

tcctaatgtt tgataaaata ctattttcag agtggtagag aggttttatt tgcctaaata 3900

gccgttatta aatggaataa caaccacatt agaccaaatt aattgcaaac acagcggcaa 3960

cctggggaga agttgaaact ccagttttgt ggattacagt tttgagtttt atgattgaca 4020

tttttaagtc ccctatttaa ggggtcaaga ttataaaaat gtgtgtctta ctaagtttct 4080

aggtcattgt gagcacttga taaatatttg ctgaatgttg tttttttgaa tgaacataag 4140

atagaaacaa aaacttctca tccagttaac tagagtgaat gtagggagaa ttgttttgct 4200

tgtaacatgg agagtttatt ttcaagtgag gaaagagaaa aaaattactc agacttgttc 4260

ctggtgaagt gcattctctg tttgtatact ttttgatgga gaaattgatc tatagaactg 4320

cttaattttt tgaggcattt agacagcaat gaaaggtagt tctccacagg acaccgaatc 4380

aaaaggagag accagactct ggcctcatac ccagcctatt tgaaacaagc tatctagttt 4440

ctcctgcaga caccttgtca acaacatgca acagtgtcag gtgccttgca ggaaaataat 4500

ctgagtccca agctagcctg tgctcatcca caatcacaat gaacatgtca aggaagaatt 4560

tgcagagact caagggaagc acaatgggat aaggtaatca ctttcagtga aaaactgttt 4620

tcttgaaaac aggcttggac acaattgaaa gctggcttcc tgcaaacaca ccaagagtct 4680

gtaatctagc ctatccatta tatgtccttt attattcatg atatcctatt cttctacctt 4740

gttgcctggt aactttttct gaggactgag tttctgcagc gatgtggtgc actcttcctg 4800

tgatgaggaa acatctgggc ccccttctgc aggctttgga agatgatgtg tcttgtcaag 4860

gggtaaaggg caaatggatt taatttctgc ttaaaactat catagacgtt ccaaatagaa 4920

tatgtaaaat ttctctgtat tagaaaaaga aacgtgatac caattgtata ttttcttttc 4980

tttatttatt ctctgtaagt ctgtcagatg ataaattgta aataacaatg attaaagagt 5040

catgctactg atggatctcc ctttctgtat aaacagtgcc agttctgggc tttgtaacct 5100

ttgctcttta tagtctttca ttcctgggga agtgatgggg catgggccca gagctggggt 5160

gtatgtggta tggacacctg tttgtgggnt ttccagcaaa ggattattta aatagacctc 5220

taacat 5226

53

gccattctcc tatcccgtgt ctgtncccat ccctgtgacc cctgacccct ggcctttgcc 60

actccccagg gaccgatgat gtggcgacca tcagttctgc tgcttctgtt gctactgagg 120

cacggggccc aggggaagcc atccccagac gcaggccctc atggccaggg gagggtgcac 180

caggcggccc ccctgagcga cgctccccca tgatgacgcc cacgggaact tccagttacg 240

accatgaggc tttcctggga cgggaagtgg ccaaggaatt cgaccaactc accccagagg 300

aaagccaggc ccgtctgggg cggatcgtgg accgcatgga ccgcgcgggg gacggcgacg 360

gctgggtgtc gctggccgag cttcgcgcgt ggatcgcgca acacgcagca gcggcacata 420

cgggactcgg tgagcgcggc ctggggacac gtacgacacg gaccgcgacg ggcgtgtggg 480

ttgggaggag ctgcgcaacg ccacctatgg ccactacgcg cccggtgaag aatttcatga 540

cgtggaggat gcagagacct acaaaaagat gctggctcgg gacgagcggc gtttccgggt 600

ggccgaccag gatggggact cgatggccac tcgagaggag ctgacagcct tcctgcaccc 660

cgaggagttc cctcacatgc gggacatcgt gattgctgaa accctggagg acctggacag 720

aaacaaagat ggctatgtcc aggtggagga gtacatcgcg gatctgtact cagccgagcc 780

tggggaggag gagccggacg tgggtgcaag acggagaggc agcagttccg ggacttccgg 840

gatctgaaca aggatgggca cctggatggg agtgaggtgg gccactgggt gctgccccct 900

gcccaggacc agcccctggt ggaagccaac cacctgctgc acgagagcga cacggacaag 960

gatgggcggc tgagcaaagc ggaaatcctg ggtaattgga acatgtttgt gggcagtcag 1020

gccaccaact atggcgagga cctgacccgg caccacgatg agctgtgagc accgcgcacc 1080

tgccacagcc tcagaggccc gcacaatgac cggaggaggg gccgctgtgg tctggccccc 1140

tccctgtcca ggccccgcag gaggcagatg cagtcccagg catcctcctg cccctgggct 1200

ctcagggacc ccctgggtcg gcttctgtcc ctgtcacacc cccaacccca gggaggggct 1260

gtcatagtcc cagaggataa gcaataccta tttctgactg agtctcccag cccagaccca 1320

gggacccttg gccccaagct cagctctaag aaccgcccca acccctccag ctccaaatct 1380

gagcctccac cacatagact gaaactcccc tggccccagc cctctcctgc ctggcctggc 1440

ctgggacacc tcctctctgc caggaggcaa taaaagccag cgccgggaaa 1490

54

tcaaaagatc ttttatttta caattngttc atttaaatca ggagctcaaa actgtacaca 60

cacagtgatt gatagataat gtctttttaa taggttcctt tttttcccct cagttttgta 120

atttatttgt tgaagaaaca gatcatttgg cctataacat ttcccagagt ctggatttcg 180

ctggccagca attttaaatt aaagctttta tggtcaataa atcacatttc ctgtccctct 240

gtgctatcat tggatccaac ccccaaatca tatgcaataa gtttagtgtt attctcttca 300

gatgcaagaa acaaagattc cctcaggata cctctagcag gaagttttat tgtaaagata 360

cacatgggat gggattaaag gatataggac ctcaaatggt g 401

55

cacgagagtg actctcctat gaaggtaaag gccacccctc ttcagttcca gtgactgaga 60

tacatttttc baatcctggg ggcaaataca gacacagcaa gttccttctt ccctttggaa 120

atttggcagc tgccttcacc agtgagcaca aagccacatt tcaaaggaaa ctgacaaatt 180

atccccagct gccagaagaa gaaatcctca ctggacggct tcctgtttcc tgtggttcat 240

tatctgattg gctgcaggga tgaaagtttt taagttcata ggactgatga tcctcctcac 300

ctctgcgttt tcagccggtt caggacaaag tccaatgact gtgctgtgct ccatagactg 360

gttcatggtc acagtgcacc cttcatgcta aacaacgatg tgtgtgtaca ctttcatgac 420

tacattgggc ctgggttgcc cccaaaccat gttcagccac acgcctacca gttcactacc 480

gtgttactga atgtggcatc agggccaaag ctgtctctca ggacatggtt atctacagca 540

ctgagataca ctactcttct aagggcacgc catctaagtt tgtgatccca gtgtcatgtg 600

ctgcccccca aaagtcccca tgggctcacc aagccctgct ccatgagagt agccagcaag 660

agcagggcca cagccagtaa ggatgagaaa tgctacgagg tgttcagctt gtcacagtcc 720

agtcaaaggc ccaactgcga ttgtccacct tgtgtcttca gtgaagaaga gcatacccag 780

gtcccttgtc accaagcagg ggctcaggag gctcaacctc tgcagccatc tcactttctt 840

gatatttctg aggattggtc tcttcacaca gatgatatga ttgggtccat gtgatcctca 900

ggtttggggt ctcctgaaga tgctatntct agaattagta tatagtgtac aaatgtctga 960

naaataagtg ctcttgtgac cctcatntga gcacttttga gaaagagaaa cctatagcaa 1020

cttcatgaat taagcctttt tctatatntt tatattcatg tgtaaacaaa aaataaaata 1080

aaattctgat cgcataaa 1098

56

cagggaagag cctggctacg gtggactgtg agactcagtg cactgtcctc ctcccagcga 60

cgcccacgct ggacccccct gccggaccct ccacccttcg gcccccaagc ttcccagggg 120

cttcctttgg actggactgt ccctgctcat ccattctcct gccaccccca gacctcctca 180

gctccaggtt gccacctcct ctcgccagag tgatgaggtc ccgggcttct gctctccgtg 240

gcccatctgc ccacaattcg ggagaccacg gaggagatgc tgcttggggg tcctgggaca 300

gggagccccc accctactcc tagcctggat gactacgtga ggtctatatc tcgactggca 360

cagcccacct ctgtgctgga caaggccacg gcccagggcc aacccaggcc accccacagg 420

ccagcccagg cctgccggaa gggccgccct gctgtgtccc tgcgagacat caccgcacgt 480

ttcagtggcc agcagcccac actgcccatg gctgatactg tggaccccct ggactggctt 540

tttggggagt cccaggaaaa gcagccaagc cagagggacc tgccaaggag gactggcccc 600

tctgctggcc tctggggtcc acatagacag atggacagca gcaagcccat gggggccccc 660

agagggaggc tctgtgaagc caggatgcct gggcattccc tggcaagacc accgcaggat 720

gggcagcaga gctctgacct aagaagctgg acttttgggc agtctgccca agccatggcc 780

tcccgccacc gcccccgccc cagcagtgtc ctcagaacac tctactcgca cctcccggtg 840

atccatgaac tctgacccct ccccagtaaa ggcttctgta gagagcatgc tgggtctgca 900

tctcctgctc gtactcctcc atggtggtca ctgcccctgg caggtctctg aaagggaaat 960

gcttttctgc agaggcccct ggcttgggca gttcacagtg agaccgaccc cctctgaata 1020

tgataacagc ctgtttcaca tgaggagatg ttaccaatcc cgttcgctct gacccttgct 1080

ggctgatcac cttgagcaac ttacttaaca tctgtgttcc tcagtttctc atgggtaata 1140

tagggataat tactggcacc tgcctcccag gccattctga cgtgtaaccc gcatatagga 1200

gcccactggc tgagtagcta ccatcatcgc tggtggggaa actggtggta ggggtgtgag 1260

ggtagtgggg gtgtcagccc cccaggtgtt tcagaacaag gcctcgggca ctcccaagtc 1320

tgcctcttgg ctcccaccct caaagcccat gttctgtgag gcccaagaga acacatggag 1380

tcttagcaaa tgcactaatg tattccgggg gactgtcacc tggcaccact ggggcactct 1440

gctggctaca actcatacgt cctgtggtgg cattgggaga gttcccccat gatgagggcc 1500

aagatagaat ctgtaccact cagtgctacc atccccaccc ctacaccact tccacacagg 1560

ggcctcatgg catggtcagg gtcccagctg tgggtgagag cagggcactg tccagctgtc 1620

cactggggaa gtcaagatgt cctaaggccc aggccagggc atctggagtc tgaaggaccc 1680

tagttcctag aggcatctgg cagcaagaag gtgaggcatc agggaacggg aatcaggctg 1740

ggactgatca gaggtgaagg gacagagaga ggagaggagg aagattgagc tgggggcaac 1800

agccaagctc acctgggcag gtctctgcca cctccttgct ctgtgagctg tcagtctagg 1860

ttattctctt tttttgtggc tatttttaat tgctttggat ttgttaaatg ttttctgtct 1920

tctgttaagt gtgttttctc tggagataga atgtaaacca tattaaaagg aaaaagagaa 1980

taacctagac tgacagctca cagagcaagg aggtggcaga gacctgccca ggtgagcttg 2040

gctgttgccc ccagctcaat cttcctcctc tcctctctct gtcccttcac ctctgatcag 2100

tcccagcctg attcccgttc cctgatgcct caccttcttg ctgccagatg cctctaggaa 2160

ctagggtcct tcagactcca gatgccctgg cctgggcctt aggacatctt gacttcccca 2220

gtggacagct ggacagtgcc ctgctctcac ccacagctgg gaccgtgacc atgccatgag 2280

gcccctgtgt ggaagtggtg tagggccaag atagaatctg taccactcag tgctaccatc 2340

cccacc 2346

57

gataaatggc tattggttgc gtatctctct ggatgtatct gtatctccag attttggggt 60

ggcagtttgc tcaggacctt ggttctctaa taggtctaat aagaaaagtc attgattttc 120

58

ggcagggcga cgtaggcggc acgtgcgggg tcgtggacga cgagccccgg ccgactggga 60

aagcggagac cgaagacgag gacgaaggga ctgagggcga ggacgaaggg cctcagtggt 120

cgccgcagga cccggcactg caaggcgtag gacagcccac aggaactgga agcataagaa 180

agaagcgatt tgtgtccagt caccgctatg tggaaaccat gcttgtggca gaccagtcga 240

tggcagaatt ccacggcagt ggtctaaagc attaccttct cacgttgttt tcggtggcag 300

ccagattgta caaacacccc agcattcgta attcagttag cctggtggtg gtgaagatct 360

tggtcatcca cgatgaacag aaggggccgg aagtgacctc caatgctgcc ctcactctgc 420

ggaacttttg caactggcag aagcagcaca acccacccag tgaccgggat gcagagcact 480

atgacacagc aattcttttc accagacagg acttgtgtgg gtcccagaca tgtgatactc 540

ttgggatggc tgatgttgga actgtgtgtg atccgagcag aagctgctcc gtcatagaag 600

atgatggttt acaagctgcc ttcaccacag cccatgaatt aggccacgtg tttaacatgc 660

cacatgatga tgcaaagcag tgtgccagcc ttaatggtgt gaaccaggat tcccacatga 720

tggcgtcaat gctttccaac ctggaccaca gccagccttg gtctccttgc agtgcctaca 780

tgattacatc atttctggat aatggtcatg gggaatgttt gatggacaag cctcagaatc 840

ccatacagct cccaggcgat ctccctggca cctcgtacga tgccaaccgg cagtgccagt 900

ttacatttgg ggaggactcc aaacactgcc ccgatgcagc cagcacatgt agcaccttgt 960

ggtgtaccgg cacctctggt ggggtgctgg tgtgtcaaac caaacacttc ccgtgggcgg 1020

atggcaccag ctgtggagaa gggaaatggt gtatcaacgg caagtgtgtg aacaaaaccg 1080

acagaaagca ttttgatacg ccttttcatg gaagctgggg aatgtggggg ccttggggag 1140

actgttcgag aacgtgcggt ggaggagtcc agtacacgat gagggaatgt gacaacccag 1200

tcccaaagaa tggagggaag tactgtgaag gcaaacgagt gcgctacaga tcctgtaacc 1260

ttgaggactg tccagacaat aatggaaaaa cctttagaga ggaacaatgt gaagcacaca 1320

acgagttttc aaaagcttcc tttgggagtg ggcctgcggt ggaatggatt cccaagtacg 1380

ctggcgtctc accaaaggac aggtgcaagc tcatctgcca agccaaaggc attggctact 1440

tcttcgtttt gcagcccaag gttgtagatg gtactccatg tagcccagat tccacctctg 1500

tctgtgtgca aggacagtgt gtaaaagctg gttgtgatcg catcatagac tccaaaaaga 1560

agtttgataa atgtggtgtt tgcgggggaa atggatctac ttgtaaaaaa atatcaggat 1620

cagttactag tgcaaaacct ggatatcatg atatcatcac aattccaact ggagccacca 1680

acatcgaagt gaaacagcgg aaccagaggg gatccaggaa caatgggcag ctttcttgcc 1740

atcaaagctg ctgatggcac atatattctt aatggtgact acactttgtc caccttagag 1800

caagacatta tgtacaaagg tgttgtcttg aggtacagcg gctcctctgc ggcattggaa 1860

agaattcgca gctttagccc tctcaaagag cccttgacca tccaggttct tactgtgggc 1920

aatgcccttc gacctaaaat taaatacacc tacttcgtaa agaagaagaa ggaatctttc 1980

aatgctatcc ccactttttc agcatgggtc attgaagagt ggggcgaatg ttctaagtca 2040

tgtgaattgg gttggcagag aagactggta gaatgccgag acattaatgg acagcctgct 2100

tccgagtgtg caaaggaagt gaagccagcc agcaccagac cttgtgcaga ccatccctgc 2160

ccccagtggc agctggggga gtggtcatca tgttctaaga cctgtgggaa gggttacaaa 2220

aaaagaagct tgaagtgtct gtcccatgat ggaggggtgt tatctcatga gagctgtgat 2280

cctttaaaga aacctaaaca tttcatagac ttttgcacaa tggcagaatg cagttaagtg 2340

gtttaagtgg tgttagcttt gagggcaagg caaagtgagg aagggctggt gcagggaaag 2400

caagaaggct ggagggatcc agcgtatctt gccagtaacc agtgaggtgt atcagtaagg 2460

tgggattatg ggggtagata gaaaaggagt tgaatcatca gagtaaactg ccagttgcaa 2520

atttgatagg atagttagtg aggattatta acctctgagc agtgatatag cataataaag 2580

ccccgggcat tattattatt atttcttttg ttacatctat tacaagttta gaaaaaacaa 2640

agcaattgtc caaaaaaagt tagaactatt acaacccctg tttcctggta cttatcaaat 2700

acttagtatc atgggggttg ggaaatgaaa agtaggagaa aagtgagatt ttactaagac 2760

ctgttttact ttacctcact aacaatgggg ggagaaagga gtacaaatag gatctttgac 2820

cagcactgtt tatggctgct atggtttcag agaatgttta tacattattt ctaccgagaa 2880

ttaaaacttc agattgttca acatgagaga aaggctcagc aacgtgaaat aacgcaaatg 2940

gcttcctctt tccttttttg gaccatctca gtctttattt gtgtaattca ttttgaggaa 3000

aaaacaactc catgtattta ttcaagtgca ttaaagtcta caatggaaaa aaagcagtga 3060

agcattagat gctggtaaaa gctagaggag acacaatgag cttagtacct ccaacttcct 3120

ttctttccta ccatgtaacc ctgctttggg aatatggatg taaagaagta acttgtgtct 3180

catgaaaatc agtacaatca cacaaggagg atgaaacgcc ggaacaaaaa tgaggtgtgt 3240

agaacagggt cccacaggtt tggggacatt gagatcactt gtcttgtggt ggggaggctg 3300

ctgaggggta gcaggtccat ctccagcagc ttgtccaaca gtcgtatcct ggtgaatgtc 3360

tgttcagctc ttctgtgaga atatgatttt ttccatatgt atatagtaaa atatgttact 3420

ataaattaca tgtactttat aagtattggt ttgggtgttc cttccaagaa ggactatagt 3480

tagtaataaa tgcctataat aacatattta tttttataca tttatttcta atgaaaaaaa 3540

cttttaaatt atatcgcttt tgtggaagtg catataaaat agagtattta tacaatatat 3600

gttactagaa ataaaagaac acttttggaa aaanaaanna annaagnnga angnnnnnta 3660

aagntgtatg ccgnggagaa naacccaaat gccgtggtga cgctag 3706

59

gcgctgggag aaggagagcc atcgccgctc gtacccgctt caacgccgcc agcctaaacg 60

gcgcccccaa ggggggcaag tacgacgacg tcaccctgat gggcgcggag gtagccagcg 120

gcggctgcat gaagaccgga ctctggaaga gcgaaactac cgtctaaggt ggggcgggcg 180

acgcggtaga cgggctggcc acgcggctcg ttcccccgct cctcggggcc ctccaaggtg 240

tctccgtagt cagcaggttg gaggcagagg agccgatggc tggaggaagc ccacaggcgg 300

atgttcccca cttgcctaga gggcatccct ctggggtagc gacagacaat cccagaaaca 360

cgcataatac atttccgtcc agcccggggc agtctgactg tcggtgccct cccaggaacg 420

gggaaggcct ccgtctgtgt gaaagggcac agcacatccc aggtgcaccc tccccaagta 480

ctcccacccc gcctactgta ccatgcggcc tcactggggg ccatcagcct caccagcaaa 540

gcagagatga gagcgtggga actgtgttct ttcctccctg ccctctactg atttcagccc 600

agcccctgcc tagatcctag gtcccttttc ctcccgagtt tggctggcac gagagctagc 660

ccagcacatg aagcaggtga tgttaagtca caaggtgctg cttttcagat ccactatgca 720

agaggggagg gtggggccac gtgaaaggca gctctagaca tcaaccagtc ctgggggagg 780

ggagtgggaa ccgggcacaa ctaggaacaa tgccaccatt cccacaggag tggtacttaa 840

accagacagc agggttcaga ggtggcacac cgggacaaag ctgaggccct gcacctcaac 900

agctgactgc caggtgcctg tgggtgaact gaggggagta gagggagagg gcaggtggaa 960

ctggggcaga atctagtcat gccctaaagc tagtcctgta aacaatggtg ccccagaaag 1020

ctgcaggtgg tgtttggaga agcagttact tttcagttac aagacccatc tccctagtct 1080

cagccttaca acaccacggg actaaggaag agcacttcct tgcctccgta aggccagagg 1140

aagaaccatc ccaatcattt gatctccagc tccacagtag agagaaacct acaaaatgtc 1200

aaaccagctt cccgactccc aggagctcaa gccaagccca gaggcagtgg ctggggtccc 1260

tgcaggtcat gaggggccta tgcctttact ccttttaaac accagcaccc gtcttttccc 1320

caacctaaaa ccaaccacca gcatttcact acaggaccaa atggaaaccg agggaaccct 1380

gggtcttggg aagaacaaca ggaaaccaag gtctgaccta gggttccctc ccagtcttca 1440

catcactctg gcctcatcac caaggtgaca gaggacacag gggaggggga aaacccacac 1500

acactccttg gaatgggtcc tgttatttat gcttgctgca cagacatatt agaagaaaaa 1560

aaaaagcttt gtattattct tccacatatg ctggctgctg tttacacacc ctgccaatgc 1620

cttagcactg gagagctttt tgcaatatgc tggggaaagg ggagggaggg aatgaaagtg 1680

ccaaagaaaa catgttttta agaactcggg ttttatacaa tagaatgttt tctagcagat 1740

gcctcttgtt ttaatatatt aaaattttgc aaagcccttt gagctactgc cttagtctac 1800

ccactgtcct tttgttatga ggtagaggat ctcatgacac catacacaca aacccatcat 1860

tgcctgtgaa tgcacgtagg gccagaattc cccagttccc gctcctctga gggttgatac 1920

tgctgggaat gccaaccact ccacaagcag agggaagccc cctcaggcct gcaggaggag 1980

ccgcagcagt gtgtccaatt caaaccagca gcaaagagcc tgacattttc ccatccatct 2040

atgaggaaag ccatctcaca gaacatggac ataggcaact tgctctccca caccaaggga 2100

tgggaatctc tcctacctat agtcatccct gcactcctga ctttactcca ggacccaggg 2160

tccaactaat ggcagagccc ctcttggttc cttcaaacaa gaaaagcaat acctacggac 2220

tggtgtacac ttccatcctt ggttataaca ggaatgttat caagctgtca gaacaggatg 2280

aagtgctccc agtggatatc catcagggag ggttagggac actcgtggca gcctgtctag 2340

cagcctgggc tctctgaaag tccctaactt cctgaggggt acgcaaatac tgttctattt 2400

cactatcaga aatgttctca tctccagtga cagtggagac agggggtaca gggcagatcc 2460

gcttcgggga cttcaacatg cagggtggca agagaagggc aggactggcc ggccgcttcc 2520

cctggggtaa acctaaggaa ttatttccca cctccccttc tccttgcccc tgtccccacc 2580

ccggtggctc cttctctcgg gtctccactt ctgctgtccc atcccgaaag gcagagcgga 2640

ccagtgactg gcggtgctgg agaaggtcac cgatgtgctt caccacagac cgtttgtcaa 2700

gtctcagaac tcgtaaccag gccagctgct cagccatccg cagcagcaca gccagcagct 2760

cctgcaggcg ggaggacgcc gggtagggca ggtccacatt tgccaattta caaaatcggg 2820

caagggaaca tgaaagccga tctgcaggct gcagcgactg ccaagccagg aaagtcgcag 2880

cagtgatgac gggcaaggga tgcctcccgg tcaccagcca cgtctcattt gccagctcca 2940

ccaactgcat tgttcgagac agcatcttct ctttgtcttc cacgtatttg gctggcacag 3000

aaggtgaagc ttggaacagt ttgaagctga aataaccaaa atgagggttg gatcttaatg 3060

atataggggc tgctctccca cagtgaggaa agacagccca ctcaagatgg ggaagctatt 3120

ctgccctcag gaatactcaa gctcactggg cagcaagtta ataaaggtag tgagagaaaa 3180

cagggcgtct tccgcttgtt aggggaaggt ggagggatgg aggagagcac gaacatttat 3240

tgggcgcctc ccaatcacca ttattctgag tgctttacaa cgttctcatt taatctacgt 3300

gcacgtgcac catcttatgt gcatgtatag ttaaaaaact ttcccatagt catccagcca 3360

ggcagtaacc aagcttcaaa tacaaggcta tttgacacca acagcctcta ctttcaacgt 3420

tatttatcag 3430

60

gggattccct cactttcccc ctacaggact cagatctggg aggcaattac cttcggagaa 60

aaacgaatag gaaaaactga agtgttactt tttttaaagc tgctgaagtt tgttggtttc 120

tcattgtttt taagcctact ggagcaataa agtttgaaga acttttacca ggtttttttt 180

atcgctgcct tgatatacac ttttcaaaat gctttggtgg gaagaagtag aggactgtta 240

tgaaagagaa gatgttcaaa agaaaacatt cacaaaatgg gtaaatgcac aattttctaa 300

gtttgggaag cagcatattg agaacctctt cagtgaccta caggatggga ggcgcctcct 360

agacctcctc gaaggcctga cagggcaaaa actgccaaaa gaaaaaggat ccacaagagt 420

tcatgccctg aacaatgtca acaaggcact gcgggttttg cagaacaata atgttgattt 480

agtgaatatt ggaagtactg acatcgtaga tggaaatcat aaactgactc ttggtttgat 540

ttggaatata atcctccact ggcaggtcaa aaatgtaatg aaaaatatca tggctggatt 600

gcaacaaacc aacagtgaaa agattctcct gagctgggtc cgacaatcaa ctcgtaatta 660

tccacaggtt aatgtaatca acttcaccac cagctggtct gatggcctgg ctttgaatgc 720

tctcatccat agtcataggc cagacctatt tgactggaat agtgtggttt gccagcagtc 780

agccacacaa cgactggaac atgcattcaa catcgccaga tatcaattag gcatagagaa 840

actactcgat cctgaagatg ttgataccac ctatccagat aagaagtcca tcttaatgta 900

catcacatca ctcttccaag ttttgcctca acaagtgagc attgaagcca tccaggaagt 960

ggaaatgttg ccaaggccac ctaaagtgac taaagaagaa cattttcagt tacatcatca 1020

aatgcactat tctcaacaga tcacggtcag tctagcacag ggatatgaga gaacttcttc 1080

ccctaagcct cgattcaaga gctatgccta cacacaggct gcttatgtca ccacctctga 1140

ccctacacgg agcccatttc cttcacagca tttggaagct cctgaagaca agtcatttgg 1200

cagttcattg atggagagtg aagtaaacct ggaccgttat caaacagctt tagaagaagt 1260

attatcgtgg cttctttctg ctgaggacac attgcaagca caaggagaga tttctaatga 1320

tgtggaagtg gtgaaagacc agtttcatac tcatgagggg tacatgatgg atttgacagc 1380

ccatcagggc cgggttggta atattctaca attgggaagt aagctgattg gaacaggaaa 1440

attatcagaa gatgaagaaa ctgaagtaca agagcagatg aatctcctaa attcaagatg 1500

ggaatgcctc agggtagcta gcatggaaaa acaaagcaat ttacatagag ttttaatgga 1560

tctccagaat cagaaactga aagagttgaa tgactggcta acaaaaacag aagaaagaac 1620

aaggaaaatg gaggaagagc ctcttggacc tgatcttgaa gacctaaaac gccaagtaca 1680

acaacataag gtgcttcaag aagatctaga acaagaacaa gtcagggtca attctctcac 1740

tcacatggtg gtggtagttg atgaatctag tggagatcac gcaactgctg ctttggaaga 1800

acaacttaag gtattgggag atcgatgggc aaacatctgt agatggacag aagaccgctg 1860

ggttctttta caagacatcc ttctcaaatg gcaacgtctt actgaagaac agtgcctttt 1920

tagtgcatgg ctttcagaaa aagaagatgc agtgaacaag attcacacaa ctggctttaa 1980

agatcaaaat gaaatgttat caagtcttca aaaactggcc gttttaaaag cggatctaga 2040

aaagaaaaag caatccatgg gcaaactgta ttcactcaaa caagatcttc tttcaacact 2100

gaagaataag tcagtgaccc agaagacgga agcatggctg gataactttg cccggtgttg 2160

ggataattta gtccaaaaac ttgaaaagag tacagcacag atttcacagg ctgtcaccac 2220

cactcagcca tcactaacac agacaactgt aatggaaaca gtaactacgg tgaccacaag 2280

ggaacagatc ctggtaaagc atgctcaaga ggaacttcca ccaccacctc cccaaaagaa 2340

gaggcagatt actgtggatt ctgaaattag gaaaaggttg gatgttgata taactgaact 2400

tcacagctgg attactcgct cagaagctgt gttgcagagt cctgaatttg caatctttcg 2460

gaaggaaggc aacttctcag acttaaaaga aaaagtcaat gccatagagc gagaaaaagc 2520

tgagaagttc agaaaactgc aagatgccag cagatcagct caggccctgg tggaacagat 2580

ggtgaatgag ggtgttaatg cagatagcat caaacaagcc tcagaacaac tgaacagccg 2640

gtggatcgaa ttctgccagt tgctaagtga gagacttaac tggctggagt atcagaacaa 2700

catcatcgct ttctataatc agctacaaca attggagcag atgacaacta ctgctgaaaa 2760

ctggttgaaa atccaaccca ccaccccatc agagccaaca gcaattaaaa gtcagttaaa 2820

aatttgtaag gatgaagtca accggctatc aggtcttcaa cctcaaattg aacgattaaa 2880

aattcaaagc atagccctga aagagaaagg acaaggaccc atgttcctgg atgcagactt 2940

tgtggccttt acaaatcatt ttaagcaagt cttttctgat gtgcaggcca gagagaaaga 3000

gctacagaca atttttgaca ctttgccacc aatgcgctat caggagacca tgagtgccat 3060

caggacatgg gtccagcagt cagaaaccaa actctccata cctcaactta gtgtcaccga 3120

ctatgaaatc atggagcaga gactcgggga attgcaggct ttacaaagtt ctctgcaaga 3180

gcaacaaagt ggcctatact atctcagcac cactgtgaaa gagatgtcga agaaagcgcc 3240

ctctgaaatt agccggaaat atcaatcaga atttgaagaa attgagggac gctggaagaa 3300

gctctcctcc cagctggttg agcattgtca aaagctagag gagcaaatga ataaactccg 3360

aaaaattcag aatcacatac aaaccctgaa gaaatggatg gctgaagttg atgtttttct 3420

gaaggaggaa tggcctgccc ttggggattc agaaattcta aaaaagcagc tgaaacagtg 3480

cagactttta gtcagtgata ttcagacaat tcagcccagt ctaaacagtg tcaatgaagg 3540

tgggcagaag ataaagaatg aagcagagcc agagtttgct tcgagacttg agacagaact 3600

caaagaactt aacactcagt gggatcacat gtgccaacag gtctatgcca gaaaggaggc 3660

cttgaaggga ggtttggaga aaactgtaag cctccagaaa gatctatcag agatgcacga 3720

atggatgaca caagctgaag aagagtatct tgagagagat tttgaatata aaactccaga 3780

tgaattacag aaagcagttg aagagatgaa gagagctaaa gaagaggccc aacaaaaaga 3840

agcgaaagtg aaactcctta ctgagtctgt aaatagtgtc atagctcaag ctccacctgt 3900

agcacaagag gccttaaaaa aggaacttga aactctaacc accaactacc agtggctctg 3960

cactaggctg aatgggaaat gcaagacttt ggaagaagtt tgggcatgtt ggcatgagtt 4020

attgtcatac ttggagaaag caaacaagtg gctaaatgaa gtagaattta aacttaaaac 4080

cactgaaaac attcctggcg gagctgagga aatctctgag gtgctagatt cacttgaaaa 4140

tttgatgcga cattcagagg ataacccaaa tcagattcgc atattggcac agaccctaac 4200

agatggcgga gtcatggatg agctaatcaa tgaggaactt gagacattta attctcgttg 4260

gagggaacta catgaagagg ctgtaaggag gcaaaagttg cttgaacaga gcatccagtc 4320

tgcccaggag actgaaaaat ccttacactt aatccaggag tccctcacat tcattgacaa 4380

gcagttggca gcttatattg cagacaaggt ggacgcagct caaatgcctc aggaagccca 4440

gaaaatccaa tctgatttga caagtcatga gatcagttta gaagaaatga agaaacataa 4500

tcaggggaag gaggctgccc aaagagtcct gtctcagatt gatgttgcac agaaaaaatt 4560

acaagatgtc tccatgaagt ttcgattatt ccagaaacca gccaattttg agctgcgtct 4620

acaagaaagt aagatgattt tagatgaagt gaagatgcac ttgcctgcat tggaaacaaa 4680

gagtgtggaa caggaagtag tacagtcaca gctaaatcat tgtgtgaact tgtataaaag 4740

tctgagtgaa gtgaagtctg aagtggaaat ggtgataaag actggacgtc agattgtaca 4800

gaaaaagcag acggaaaatc ccaaagaact tgatgaaaga gtaacagctt tgaaattgca 4860

ttataatgag ctgggagcaa aggtaacaga aagaaagcaa cagttggaga aatgcttgaa 4920

attgtcccgt aagatgcgaa aggaaatgaa tgtcttgaca gaatggctgg cagctacaga 4980

tatggaattg acaaagagat cagcagttga aggaatgcct agtaatttgg attctgaagt 5040

tgcctgggga aaggctactc aaaaagagat tgagaaacag aaggtgcacc tgaagagtat 5100

cacagaggta ggagaggcct tgaaaacagt tttgggcaag aaggagacgt tggtggaaga 5160

taaactcagt cttctgaata gtaactggat agctgtcacc tcccgagcag aagagtggtt 5220

aaatcttttg ttggaatacc agaaacacat ggaaactttt gaccagaatg tggaccacat 5280

cacaaagtgg atcattcagg ctgacacact tttggatgaa tcagagaaaa agaaacccca 5340

gcaaaaagaa gacgtgctta agcgtttaaa ggcagaactg aatgacatac gcccaaaggt 5400

ggactctaca cgtgaccaag cagcaaactt gatggcaaac cacggtgacc actgcaggaa 5460

attagtagag ccccaaatct cagagctcaa ccatcgattt gcagccattt cacacagaat 5520

taagactgga aaggcctcca ttcctttgaa ggaattggag cagtttaact cagatataca 5580

aaaattgctt gaaccactgg aggctgaaat tcagcagggg gtgaatctga aagaggaaga 5640

cttcaataaa gatatgaatg aagacaatga gggtactgta aaagaattgt tgcaaagagg 5700

agacaactta caacaaagaa tcacagatga gagaaagaga gaggaaataa agataaaaca 5760

gcagctgtta cagacaaaac ataatgctct caaggatttg aggtctcaaa gaagaaaaaa 5820

ggctctagaa atttctcatc agtggtatca gtacaagagg caggctgatg atctcctgaa 5880

atgcttggat gacattgaaa aaaaattagc cagcctacct gagcccagag atgaaaggaa 5940

aataaaggaa attgatcggg aattgcagaa gaagaaagag gagctgaatg cagtgcgtag 6000

gcaagctgag ggcttgtctg aggatggggc cgcaatggca gtggagccaa ctcagatcca 6060

gctcagcaag cgctggcggg aaattgagag caaatttgct cagtttcgaa gactcaactt 6120

tgcacaaatt cacactgtcc gtgaagaaac gatgatggtg atgactgaag acatgccttt 6180

ggaaatttct tatgtgcctt ctacttattt gactgaaatc actcatgtct cacaagccct 6240

attagaagtg gaacaacttc tcaatgctcc tgacctctgt gctaaggact ttgaagatct 6300

ctttaagcaa gaggagtctc tgaagaatat aaaagatagt ctacaacaaa gctcaggtcg 6360

gattgacatt attcatagca agaagacagc agcattgcaa agtgcaacgc ctgtggaaag 6420

ggtgaagcta caggaagctc tctcccagct tgatttccaa tgggaaaaag ttaacaaaat 6480

gtacaaggac cgacaagggc gatttgacag atctgttgag aaatggcggc gttttcatta 6540

tgatataaag atatttaatc agtggctaac agaagctgaa cagtttctca gaaagacaca 6600

aattcctgag aattgggaac atgctaaata caaatggtat cttaaggaac tccaggatgg 6660

cattgggcag cggcaaactg ttgtcagaac attgaatgca actggggaag aaataattca 6720

gcaatcctca aaaacagatg ccagtattct acaggaaaaa ttgggaagcc tgaatctgcg 6780

gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag aggctagaag aacaaaagaa 6840

tatcttgtca gaatttcaaa gagatttaaa tgaatttgtt ttatggttgg aggaagcaga 6900

taacattgct agtatcccac ttgaacctgg aaaagagcag caactaaaag aaaagcttga 6960

gcaagtcaag ttactggtgg aagagttgcc cctgcgccag ggaattctca aacaattaaa 7020

tgaaactgga ggacccgtgc ttgtaagtgc tcccataagc ccagaagagc aagataaact 7080

tgaaaataag ctcaagcaga caaatctcca gtggataaag gtttccagag ctttacctga 7140

gaaacaagga gaaattgaag ctcaaataaa agaccttggg cagcttgaaa aaaagcttga 7200

agaccttgaa gagcagttaa atcatctgct gctgtggtta tctcctatta ggaatcagtt 7260

ggaaatttat aaccaaccaa accaagaagg accatttgac gttcaggaaa ctgaaatagc 7320

agttcaagct aaacaaccgg atgtggaaga gattttgtct aaagggcagc atttgtacaa 7380

ggaaaaacca gccactcagc cagtgaagag gaagttagaa gatctgagct ctgagtggaa 7440

ggcggtaaac cgtttacttc aagagctgag ggcaaagcag cctgacctag ctcctggact 7500

gaccactatt ggagcctctc ctactcagac tgttactctg gtgacacaac ctgtggttac 7560

taaggaaact gccatctcca aactagaaat gccatcttcc ttgatgttgg aggtacctgc 7620

tctggcagat ttcaaccggg cttggacaga acttaccgac tggctttctc tgcttgatca 7680

agttataaaa tcacagaggg tgatggtggg tgaccttgag gatatcaacg agatgatcat 7740

caagcagaag gcaacaatgc aggatttgga acagaggcgt ccccagttgg aagaactcat 7800

taccgctgcc caaaatttga aaaacaagac cagcaatcaa gaggctagaa caatcattac 7860

ggatcgaatt gaaagaattc agaatcagtg ggatgaagta caagaacacc ttcagaaccg 7920

gaggcaacag ttgaatgaaa tgttaaagga ttcaacacaa tggctggaag ctaaggaaga 7980

agctgagcag gtcttaggac aggccagagc caagcttgag tcatggaagg agggtcccta 8040

tacagtagat gcaatccaaa agaaaatcac agaaaccaag cagttggcca aagacctccg 8100

ccagtggcag acaaatgtag atgtggcaaa tgacttggcc ctgaaacttc tccgggatta 8160

ttctgcagat gataccagaa aagtccacat gataacagag aatatcaatg cctcttggag 8220

aagcattcat aaaagggtga gtgagcgaga ggctgctttg gaagaaactc atagattact 8280

gcaacagttc cccctggacc tggaaaagtt tcttgcctgg cttacagaag ctgaaacaac 8340

tgccaatgtc ctacaggatg ctacccgtaa ggaaaggctc ctagaagact ccaagggagt 8400

aaaagagctg atgaaacaat ggcaagacct ccaaggtgaa attgaagctc acacagatgt 8460

ttatcacaac ctggatgaaa acagccaaaa aatcctgaga tccctggaag gttccgatga 8520

tgcagtcctg ttacaaagac gtttggataa catgaacttc aagtggagtg aacttcggaa 8580

aaagtctctc aacattaggt cccatttgga agccagttct gaccagtgga agcgtctgca 8640

cctttctctg caggaacttc tggtgtggct acagctgaaa gatgatgaat taagccggca 8700

ggcacctatt ggaggcgact ttccagcagt tcagaagcag aacgatgtac atagggcctt 8760

caagagggaa ttgaaaacta aagaacctgt aatcatgagt actcttgaga ctgtacgaat 8820

atttctgaca gagcagcctt tggaaggact agagaaactc taccaggagc ccagagagct 8880

gcctcctgag gagagagccc agaatgtcac tcggcttcta cgaaagcagg ctgaggaggt 8940

caatactgag tgggaaaaat tgaacctgca ctccgctgac tggcagagaa aaatagatga 9000

gacccttgaa agactccagg aacttcaaga ggccacggat gagctggacc tcaagctgcg 9060

ccaagctgag gtgatcaagg gatcctggca gcccgtgggc gatctcctca ttgactctct 9120

ccaagatcac ctcgagaaag tcaaggcact tcgaggagaa attgcgcctc tgaaagagaa 9180

cgtgagccac gtcaatgacc ttgctcgcca gcttaccact ttgggcattc agctctcacc 9240

gtataacctc agcactctgg aagacctgaa caccagatgg aagcttctgc aggtggccgt 9300

cgaggaccga gtcaggcagc tgcatgaagc ccacagggac tttggtccag catctcagca 9360

ctttctttcc acgtctgtcc agggtccctg ggagagagcc atctcgccaa acaaagtgcc 9420

ctactatatc aaccacgaga ctcaaacaac ttgctgggac catcccaaaa tgacagagct 9480

ctaccagtct ttagctgacc tgaataatgt cagattctca gcttatagga ctgccatgaa 9540

actccgaaga ctgcagaagg ccctttgctt ggatctcttg agcctgtcag ctgcatgtga 9600

tgccttggac cagcacaacc tcaagcaaaa tgaccagccc atggatatcc tgcagattat 9660

taattgtttg accactattt atgaccgcct ggagcaagag cacaacaatt tggtcaacgt 9720

ccctctctgc gtggatatgt gtctgaactg gctgctgaat gtttatgata cgggacgaac 9780

agggaggatc cgtgtcctgt cttttaaaac tggcatcatt tccctgtgta aagcacattt 9840

ggaagacaag tacagatacc ttttcaagca agtggcaagt tcaacaggat tttgtgacca 9900

gcgcaggctg gggcctcctt ctgcatgatt ctatccaaat tccaagacag ttgggtgaag 9960

ttgcatcctt tgggggcagt aacattgagc caagtgtccg gagctgcttc caatttgcta 10020

ataataagcc agagatcgaa gcggccctct tcctagactg gatgagactg gaaccccagt 10080

ccatggtgtg gctgcccgtc ctgcacagag tggctgctgc agaaactgcc aagcatcagg 10140

ccaaatgtaa catctgcaaa gagtgtccaa tcattggatt caggtacagg agtctaaagc 10200

actttaatta tgacatctgc caaagctgct ttttttctgg tcgagttgca aaaggccata 10260

aaatgcacta tcccatggtg gaatattgca ctccgactac atcaggagaa gatgttcgag 10320

actttgccaa ggtactaaaa aacaaatttc gaaccaaaag gtattttgcg aagcatcccc 10380

gaatgggcta cctgccagtg cagactgtct tagaggggga caacatggaa actcccgtta 10440

ctctgatcaa cttctggcca gtagattctg cgcctgcctc gtcccctcag ctttcacacg 10500

atgatactca ttcacgcatt gaacattatg ctagcaggct agcagaaatg gaaaacagca 10560

atggatctta tctaaatgat agcatctctc ctaatgagag catagatgat gaacatttgt 10620

taatccagca ttactgccaa agtttgaacc aggactcccc cctgagccag cctcgtagtc 10680

ctgcccagat cttgatttcc ttagagagtg aggaaagagg ggagctagag agaatcctag 10740

cagatcttga ggaagaaaac aggaatctgc aagcagaata tgaccgtcta aagcagcagc 10800

acgaacataa aggcctgtcc ccactgccgt cccctcctga aatgatgccc acctctcccc 10860

agagtccccg ggatgctgag ctcattgctg aggccaagct actgcgtcaa cacaaaggcc 10920

gcctggaagc caggatgcaa atcctggaag accacaataa acagctggag tcacagttac 10980

acaggctaag gcagctgctg gagcaacccc aggcagaggc caaagtgaat ggcacaacgg 11040

tgtcctctcc ttctacctct ctacagaggt ccgacagcag tcagcctatg ctgctccgag 11100

tggttggcag tcaaacttcg gactccatgg gtgaggaaga tcttctcagt cctccccagg 11160

acacaagcac agggttagag gaggtgatgg agcaactcaa caactccttc cctagttcaa 11220

gaggaagaaa tacccctgga aagccaatga gagaggacac aatgtaggaa gtcttttcca 11280

catggcagat gatttgggca gagcgatgga gtccttagta tcattcatga cagatgaaga 11340

aggagcagaa taaatgtttt acaactcctg attcccgcat ggtttttata atattcatac 11400

aacaaagagg attagacagt aagagtttac aagaaataaa tctatatttt tgtgaagggt 11460

agtggtatta tactgtagat ttcagtagtt tctaagtctg ttattgtttt gttaacaatg 11520

gcaggtttta cacgtctatg caattgtaca aaaaagttat aagaaaacta catgtaaaat 11580

cttgatagct aaataacttg ccatttcttt atatggaacg cattttgggt tgtttaaaaa 11640

tttataacag ttataaagaa agattgtaaa ctaaagtgtg ctttataaaa aaaagttgtt 11700

tataaaaacc cctaaaaaca nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11760

nactttgagg cagcgcattg ttttgcatcc ttttggcgtg atatccatat gaaattcatg 11820

gctttttctt tttttgcata ttaaagataa gacttcctct accaccacac caaatgacta 11880

ctacacactg ctcatttgag aactgtcagc tgagtggggc aggcttgagt tttcatttca 11940

tatatctata tgtctataag tatataaata ctatagttat atagataaag agatacgaat 12000

ttctatagac tgactttttc cattttttaa atgttcatgt cacatcctaa tagaaagaaa 12060

ttacttctag tcagtcatcc aggcttacct gcttggtcta gaatggattt ttcccggagc 12120

cggaagccag gaggaaacta caccacacta aaacattgtc tacagctcca gatgtttctc 12180

attttaaaca actttccact gacaacgaaa gtaaagtaaa gtattggatt tttttaaagg 12240

gaacatgtga atgaatacac aggacttatt atatcagagt gagtaatcgg ttgnttggtt 12300

gattgattga ttgattgata cattcagctt cctgctgcta gcaatgccac gatttagatt 12360

taatgatgct tcagtggaaa tcaatcagaa ggtattctga ccttgtgaac atcagaaggt 12420

attttttaac tcccaagcag tagcaggacg atgatagggc tggagggcta tggattccca 12480

gcccatccct gtgaaggagt aggccactct ttaagtgaag gattggatga ttgttcataa 12540

tacataaagt tctctgtaat tacaactaaa ttattatgcc ctcttctcac agtcaaaagg 12600

aactgggtgg tttggttttt gttgcttttt tagatttatt gtcccatgtg ggatgagttt 12660

ttaaatgcca caagacataa tttaaaataa ataaactttg ggaaaaggtg taaaacagta 12720

gccccatcac atttgtgata ctgacaggta tcaacccaga agcccatgaa ctgtgtttcc 12780

atcctttgca tttctctgcg agtagttcca cacaggtttg taagtaaagt aagtaagaaa 12840

gaaggcaaat tgattcaaat gttacaaaaa aacccttctt ggtggattag acaggttaaa 12900

tatataaaca aacaaacaaa aattgctcaa aaaagaggag aaaagctcaa gaggaaaagc 12960

taaggactgg taggaaaaag ctttactctt tcatgccatt ttatttcttt ttgattttta 13020

aatcattcat tcaatagata ccaccgtgtg acctataatt ttgcaaatct gttacctctg 13080

acatcaagtg taattagctt ttggagagtg ggctgacatc aagtgtaatt agcttttgga 13140

gagtgggttt tgtccattat taataattaa ttaattaaca tcaaacacgg gcttctcatg 13200

ctatttctac ctcactttgg ttttggggtg ttcctgataa ttgtgcacac ctgagttcac 13260

agcttcacca cttgtccatt gcgttatttt ctttttcctt tataattctt tctttttcct 13320

tcataatttt caaaagaaaa cccaaagctc taaggtaaca aattaccaaa ttacatgaag 13380

atttggtttt tgtcttgcat ttttttcctt tatgtgacgc tggacctttt ctttacccaa 13440

ggatttttaa aactcagatt taaaacaagg ggttacttta catcctacta agaagtttaa 13500

gtaagtaagt ttcattctaa aatcagaggt aaatagagtg cataaataat tttgttttaa 13560

tctttttgtt tttcttttag acacattagc tctggagtga gtctgtcata atatttgaac 13620

aaaaattgag agctttattg ctgcatttta agcataatta atttggacat tatttcgtgt 13680

tgtgttcttt ataaccacca agtattaaac tgtaaatcat aatgtaactg aagcataaac 13740

atcacatggc atgttttgtc attgttttca ggtactgagt tcttacttga gtatcataat 13800

atattgtgtt ttaacaccaa cactgtaaca tttacgaatt atttttttaa acttcagttt 13860

tactgcattt tcacaacata tcagacttca ccaaatatat gccttactat tgtattatag 13920

tactgcttta ctgtgtatct caataaagca cgcagttatg ttacaaaana aaaaaaa 13977

61

tcgggatcga tctggagctc cgggaatttc cctggcccgg gactccgggc tttccagccc 60

caaccatgca taaaaggggt tcgccgttct cggagagcca cagagcccgg gccacaggca 120

gctccttgcc agctctcccg cttctcgcac agccgctgcg aaccgcctgc tgagccccca 180

tggcccgcgc cacgctctcc gccgccccca gcaatccccg gctcctgcgg gtggcgctgc 240

tgctcctgct cctggtggcc gccagccggc gcgcagcagg agcgcccctg gccactgcaa 300

ctgcgctgcc agtgccttgc agaccctgcc agggaattca ccttcaagaa catccaaagt 360

gtgaaggtga agtcccccgg accccactgc gcccaaaccg aagtcatagc cacactcaag 420

aatgggcaga aagcttgtct caaccccgca tcgcccatgg ttaagaaaat catcgaaaag 480

atgctgaaaa atggcaaatc caactgacca gaaggaagga ggaagcttat tggtggctgt 540

tcctgaagga ggccctgccc ttacaggaac agaagaggaa agagagacac agctgcagag 600

gccacctggg attgcgccta atgtgtttga gcatcactta ggagaaggcn ccgattaatn 660

aattnattaa tttatnnatt ggttggtttt agaagattct atgttaatat tttatgtgta 720

aaataaggtt atgattgaat ctacttgcac actctcccat tatatttatt gtttatttta 780

ggtcaaaccc aagttagttc aatcctgatt catatttaat ttgaagatag aaggtttgca 840

gatattctct agtcatttgt taatatttct tcgtgatgac atatcacatg tcagccactg 900

tgatagaggc tgaggaatcc aagaaaatgg ccagtaagat caatgtgacg gcagggaaat 960

gtatgtgtgt ctattttgta actgtaaaga tgaatgtcag ttgttattta ttgaaatgat 1020

ttcacagtgt gtggtcaaca tttctcatgt tgaagcttta agaactaaaa tgttctaaat 1080

atcccttgga cattttatgt ctttcttgta aggcatactg ccttgtttaa tgttaattat 1140

gcagtgtttc cctctgtgtt agagcagaga ggtttcgata tttattgatg ttttcacaaa 1200

gaacaggaaa ataaaatatt taaaaatat 1229

62

cctagctggg atattggagc agcaagaggc tgggaagcca tcacttacct tgcactgaga 60

aagaagacaa aggccagtat gcacagcttt cctccactgc tggctgctgc tgttctgggg 120

tgtggtgtct cacagcttcc cagcgactct agaaacacaa gagcaagatg tggacttagt 180

ccagaaatac ctggaaaaat actacaacct gaagaatgat gggaggcaag ttgaaaagcg 240

gagaaatagt ggcccagtgg ttgaaaaatt gaagcaaatg caggaattct ttgggctgaa 300

agtgactggg aaaccagatg ctgaaaccct gaaggtgatg aagcagccca gatgtggagt 360

gcctgatgtg gctcagtttg tcctcactga ggggaaccct cgctgggagc aaacacatct 420

gacctacagg attgaaaatt acacgccaga tttgccaaga gcagatgtgg accatgccat 480

tgagaaagcc ttccaactct ggagtaatgt cacacctctg acattcacca aggtctctga 540

gggtcaagca gacatcatga tatcttttgt caggggagat catcgggaca actctccttt 600

tgatggacct ggaggaaatc ttgctcatgc ttttcaacca ggcccaggta ttggagggga 660

tgctcatttt gatgaagatg aaaggtggac caacaatttc agagagtaca acttacatcg 720

tgttgcggct catgaactcg gccattctct tggactctcc cattctactg atatcggggc 780

tttgatgtac cctagctaca ccttcagtgg tgatgttcag ctagctcagg atgacattga 840

tggcatccaa gccatatatg gacgttccca aaatcctgtc cagcccatcg gcccacaaac 900

cccaaaagcg tgtgacagta agctaacctt tgatgctata actacgattc ggggagaagt 960

gatgttcttt aaagacagat tctacatgcg cacaaatccc ttctacccgg aagttgagct 1020

caatttcatt tctgttttct ggccacaact gccaaatggg cttgaagctg cttacgaatt 1080

tgccgacaga gatgaagtcc ggtttttcaa agggaataag tactgggctg ttcagggaca 1140

gaatgtgcta cacggatacc ccaaggacat ctacagctcc tttggcttcc ctagaactgt 1200

gaagcatatc gatgctgctc tttctgagga aaacactgga aaaacctact tctttgttgc 1260

taacaaatac tggaggtatg atgaatataa acgatctatg gatccaggtt atcccaaaat 1320

gatagcacat gactttcctg gaattggcca caaagttgat gcagttttca tgaaagatgg 1380

atttttctat ttctttcatg gaacaagaca atacaaattt gatcctaaaa cgaagagaat 1440

tttgactctc cagaaagcta atagctggtt caactgcagg aaaaattgaa cattactaat 1500

ttgaatggaa aacacatggt gtgagtccaa agaaggtgtt ttcctgaaga actgtctatt 1560

ttctcagtca tttttaacct ctagagtcac tgatacacag aatataatct tatttatacc 1620

tcagtttgca tattttttta ctatttagaa tgtagccctt tttgtactga tataatttag 1680

ttccacaaat ggtgggtaca aaaagtcaag tttgtggctt atggattcat ataggccaga 1740

gttgcaaaga tcttttccag agtatgcaac tctgacgttg atcccagaga gcagcttcag 1800

tgacaaacat atcctttcaa gacagaaaga gacaggagac atgagtcttt gccggaggaa 1860

aagcagctca agaacacatg tgcagtcact ggtgtcaccc tggataggca agggataact 1920

cttctaacac aaaataagtg ttttatgttt ggaataaagt caaccttgtt tctactgttt 1980

t 1981

63

gaattcgcac tgctctgaga atttgtgagc agcccctaac aggctgttac ttcactacaa 60

ctgacgatat gatcatctta atttacttat ttctcttgct atgggaagac actcaaggat 120

ggggattcaa ggatggaatt tttcataact ccatatggct tgaacgagca gccggtgtgt 180

accacagaga agcacggtct ggcaaataca agctcaccta cgcagaagct aaggcggtgt 240

gtgaatttga aggcggccat ctcgcaactt acaagcagct agaggcagcc agaaaaattg 300

gatttcatgt ctgtgctgct ggatggatgg ctaagggcag agttggatac cccattgtga 360

agccagggcc ccaactgtgg atttggaaaa actggcatta ttgattatgg aatccgtctc 420

aataggagtg aaagatggga tgcctattgc tacaacccac acgcaaagga gtgtggtggc 480

gtctttacag atccaaagca aatttttaaa tctccaggct tcccaaatga gtacgaagat 540

aaccaaatct gctactggca cattagactc aagtatggtc agcgtattca cctgagtttt 600

ttagattttg accttgaaga tgacccaggt tgcttggctg attatgttga aatatatgac 660

agttacgatg atgtccatgg ctttgtggga agatactgtg gagatgagct tccagatgac 720

atcatcagta caggaaatgt catgaccttg aagtttctaa gtgatgcttc agtgacagct 780

ggaggtttcc aaatcaaata tgttgcaatg gatcctgtat ccaaatccag tcaaggaaaa 840

aatacaagta ctacttctac tggaaataaa aactttttag ctggaagatt tagccactta 900

taaaaaaaaa aaaaggatga tcaaaacaca cagtgtttat gttggaatct tttggaactc 960

ctttgatctc actgttatta ttaacattta tttattattt ttctaaatgt gaaagcaata 1020

cataatttag ggaaaattgg aaaatatagg aaactttaaa cgagaaaatg aaacctctca 1080

taatcccact gcatagaaat aacaagcgtt aacattttca tatttttttc tttcagtcat 1140

ttttctattt gtggtatatg tatatatgta cctatatgta tttgcatttg aaattttgga 1200

atcctgctct atgtacagtt ttgtattata ctttttaaat cttgaacttt ataaacattt 1260

tctgaaatca ttgattattc tacaaaaaca tgattttaaa cagctgtaaa atattctatg 1320

atatgaatgt tttatgcatt atttaagcct gtctctattg ttggaatttc aggtcatttt 1380

cataaatatt gttgcaataa atatccttga acacacatat tgtgcacctc tctaattatt 1440

taanacaagg acctngnaat ngnantnctg aatcaaaggt taattccaat aaaattntcn 1500

gttttnatag gcaaaaatga ngcctcactg tagnntgaat tngcatnnct ttattcatga 1560

ganngatggt tntntaantt tttgttaatt ttttttgtga annatttttc catgccnttt 1620

ngtcactatt tttaaaaact gatataatct tcnctattga tttgttagaa antattanat 1680

atgtccatgt ttgtcatata tgctntaatt taatttttag tttatatttt gtct 1734

64

gcactcccaa agaactgggt actcaacact gagcagatct gttctttgag ctaaaaacca 60

tgtgctgtac caagagtttg ctcctggctg ctttgatgtc agtgctgcta ctccacctct 120

gcggcgaatc agaagcagca agcaactttg actgctgtct tggatacaca gaccgtattc 180

ttcatcctaa atttattgtg ggcttcacac ggcagctggc caatgaaggc tgtgacatca 240

atgctatcat ctttcacaca aagaaaaagt tgtctgtgtg cgcaaatcca aaacagactt 300

gggtgaaata tattgtgcgt ctcctcagta aaaaagtcaa gaacatgtaa aaactgtggc 360

ttttctggaa tggaattgga catagcccaa gaacagaaag aaccttgctg gggttggagg 420

tttcacttgc acatcatgga gggtttagtg cttatctaat ttgtgcctca ctggacttgt 480

ccaattaatg aagttgattc atattgcatc atagtttgct ttgtttaagc atcacattaa 540

agttaaactg tattttatgt tatttatagc tgtaggtttt ctgtgtttag ctatttaata 600

ctaattttcc ataagctatt ttggtttagt gcaaagtata aaattatatt tgggggggaa 660

taagattata tggactttct tgcaagcaac aagctatttt ttaaaaaaaa ctatttaaca 720

ttcttttgtt tatattgttt tgtctcctaa attgttgtaa ttgcattata aaataagaaa 780

aatattaata agacaaatat tgaaaataaa gaaacaaaaa gttaaaaaaa a 831

65

acgcggcgcg gaggctggcc cgggacgcgc ccggagccca gggaaggagg gaggagggga 60

gggtcgcggc cggccgccat ggggccgggg gcccgtggcc gccgccgccg ccgtcgcccg 120

atgtcgccgc caccgccacc gccacccgtg cgggcgctgc ccctgctgct gctgctagcg 180

gggccggggg ctgcagcccc cccttgcctg gacggaagcc cgtgtgcaaa tggaggtcgt 240

tgcacccagc tgccctcccg ggaggctgcc tgcctgtgcc cgcctggctg ggtgggtgag 300

cggtgtcagc tggaggaccc ctgtcactca ggcccctgtg ctggccgtgg tgtctgccag 360

agttcagtgg tggctggcac cgcccgattc tcatgccggt gcccccgtgg cttccgaggc 420

cctgactgct ccctgccaga tccctgcctc agcagccctt gtgcccacgg tgcccgctgc 480

tcagtggggc ccgatggacg cttcctctgc tcctgcccac ctggctacca gggccgcagc 540

tgccgaagcg acgtggatga gtgccgggtg ggtgagccct gccgccatgg tggcacctgc 600

ctcaacacac ctggctcctt ccgctgccag tgtccagctg gctacacagg gccactatgt 660

gagaaccccg cggtgccctg tgcgccctca ccatgccgta acgggggcac ctgcaggcag 720

agtggcgacc tcacttacga ctgtgcctgt cttcctgggt ttgagggtca gaattgtgaa 780

gtgaacgtgg acgactgtcc aggacaccga tgtctcaatg gggggacatg cgtggatggc 840

gtcaacacct ataactgcca gtgccctcct gagtggacag gccagttctg cacggaggac 900

gtggatgagt gtcagctgca gcccaacgcc tgccacaatg ggggtacctg cttcaacacg 960

ctgggtggcc acagctgcgt gtgtgtcaat ggctggacag gcgagagctg cagtcagaat 1020

atcgatgact gtgccacagc cgtgtgcttc catggggcca cctgccatga ccgcgtggct 1080

tctttctact gtgcctgccc catgggcaag actggcctcc tgtgtcacct ggatgacgcc 1140

tgtgtcagca acccctgcca cgaggatgct atctgtgaca caaatccggt gaacggccgg 1200

gccatttgca cctgtcctcc cggcttcacg ggtggggcat gtgaccagga tgtggacgag 1260

tgctctatcg gcgccaaccc ctgcgagcac ttgggcaggt gcgtgaacac gcagggctcc 1320

ttcctgtgcc agtgcggtcg tggctacact ggacctcgct gtgagaccga tgtcaacgag 1380

tgtctgtcgg ggccctgccg aaaccaggcc acgtgcctcg accgcatagg ccagttcacc 1440

tgtatctgta tggcaggctt cacaggaacc tattgcgagg tggacattga cgagtgtcag 1500

agtagcccct gtgtcaacgg tggggtctgc aaggaccgag tcaatggctt cagctgcacc 1560

tgcccctcgg gcttcagcgg ctccacgtgt cagctggacg tggacgaatg cgccagcacg 1620

ccctgcagga atggcgccaa atgcgtggac cagcccgatg gctacgagtg ccgctgtgcc 1680

gagggctttg agggcacgct gtgtgatcgc aacgtggacg actgctcccc tgacccatgc 1740

caccatggtc gctgcgtgga tggcatcgcc agcttctcat gtgcctgtgc tcctggctac 1800

acgggcacac gctgcgagag ccaggtggac gaatgccgca gccagccctg ccgccatggc 1860

ggcaaatgcc tagacctggt ggacaagtac ctctgccgct gcccttctgg gaccacaggt 1920

gtgaactgcg aagtgaacat tgacgactgt gccagcaacc cctgcacctt tggagtctgc 1980

cgtgatggca tcaaccgcta cgactgtgtc tgccaacctg gcttcacagg gcccctttgt 2040

aacgtggaga tcaatgagtg tgcttccagc ccatgcggcg agggaggttc ctgtgtggat 2100

ggggaaaatg gcttccgctg cctctgcccg cctggctcct tgcccccact ctgcctcccc 2160

ccgagccatc cctgtgccca tgagccctgc agtcacggca tctgctatga tgcacctggc 2220

gggttccgct gtgtgtgtga gcctggctgg agtggccccc gctgcagcca gagcctggcc 2280

cgagacgcct gtgagtccca gccgtgcagg gccggtggga catgcagcag cgatggaatg 2340

ggtttccact gcacctgccc gcctggtgtc cagggacgtc agtgtgaact cctctccccc 2400

tgcaccccga acccctgtga gcatgggggc cgctgcgagt ctgcccctgg ccagctgcct 2460

gtctgctcct gcccccaggg ctggcaaggc ccacgatgcc agcaggatgt ggacgagtgt 2520

gctggccccg caccctgtgg ccctcatggt atctgcacca acctggcagg gagtttcagc 2580

tgcacctgcc atggagggta cactggccct tcctgtgatc aggacatcaa tgactgtgac 2640

cccaacccat gcctgaacgg tggctcgtgc caagacggcg tgggctcctt ttcctgctcc 2700

tgcctccctg gtttcgccgg cccacgatgc gcccgcgatg tggatgagtg cctgagcaac 2760

ccctgcggcc cgggcacctg taccgaccac gtggcctcct tcacctgcac ctgcccgccg 2820

ggctacggag gcttccactg cgaacaggac ctgcccgact gcagccccag ctcctgcttc 2880

aatggcggga cctgtgtgga cggcgtgaac tcgttcagct gcctgtgccg tcccggctac 2940

acaggagccc actgccaaca tgaggcagac ccctgcctct cgcggccctg cctacacggg 3000

ggcgtctgca gcgccgccca ccctggcttc cgctgcacct gcctcgagag cttcacgggc 3060

ccgcagtgcc agacgctggt ggattggtgc agccgccagc cttgtcaaaa cgggggtcgc 3120

tgcgtccaga ctggggccta ttgcctttgt ccccctggat ggagcggacg cctctgtgac 3180

atccgaagct tgccctgcag ggaggccgca gcccagatcg gggtgcggct ggagcagctg 3240

tgtcaggcgg gtgggcagtg tgtggatgaa gacagctccc actactgcgt gtgcccagag 3300

ggccgtactg gtagccactg tgagcaggag gtggacccct gcttggccca gccctgccag 3360

catgggggga cctgccgtgg ctatatgggg ggctacatgt gtgagtgtct tcctggctac 3420

aatggtgata actgtgagga cgacgtggac gagtgtgcct cccagccctg ccagcacggg 3480

ggttcatgca ttgacctcgt ggcccgctat ctctgctcct gtcccccagg aacgctgggg 3540

gtgctctgcg agattaatga ggatgactgc ggcccaggcc caccgctgga ctcagggccc 3600

cggtgcctac acaatggcac ctgcgtggac ctggtgggtg gtttccgctg cacctgtccc 3660

ccaggataca ctggtttgcg ctgcgaggca gacatcaatg agtgtcgctc aggtgcctgc 3720

cacgcggcac acacccggga ctgcctgcag gacccaggcg gaggtttccg ttgcctttgt 3780

catgctggct tctcaggtcc tcgctgtcag actgtcctgt ctccctgcga gtcccagcca 3840

tgccagcatg gaggccagtg ccgtcctagc ccgggtcctg ggggtgggct gaccttcacc 3900

tgtcactgtg cccagccgtt ctggggtccg cgttgcgagc gggtggcgcg ctcctgccgg 3960

gagctgcagt gcccggtggg cgtcccatgc cagcagacgc cccgcgggcc gcgctgcgcc 4020

tgccccccag ggttgtcggg accctcctgc cgcagcttcc cggggtcgcc gccgggggcc 4080

agcaacgcca gctgcgcggc cgccccctgt ctccacgggg gctcctgccg ccccgcgccg 4140

ctcgcgccct tcttccgctg cgcttgcgcg cagggctgga ccgggccgcg ctgcgaggcg 4200

cccgccgcgg cacccgaggt ctcggaggag ccgcggtgcc cgcgcgccgc ctgccaggcc 4260

aagcgcgggg accagcgctg cgaccgcgag tgcaacagcc caggctgcgg ctgggacggc 4320

ggcgactgct cgctgagcgt gggcgacccc tggcggcaat gcgaggcgct gcagtgctgg 4380

cgcctcttca acaacagccg ctgcgacccc gcctgcagct cgcccgcctg cctctacgac 4440

aacttcgact gccacgccgg tggccgcgag cgcacttgca acccggtgta cgagaagtac 4500

tgcgccgacc actttgccga cggccgctgc gaccagggct gcaacacgga ggagtgcggc 4560

tgggatgggc tggattgtgc cagcgaggtg ccggccctgc tggcccgcgg cgtgctggtg 4620

ctcacagtgc tgctgccgcc ggaggagcta ctgcgttcca gcgccgactt tctgcagcgg 4680

ctcagcgcca tcctgcgcac ctcgctgcgc ttccgcctgg acgcgcacgg ccaggccatg 4740

gtcttccctt accaccggcc tagtcctggc tccgaacccc gggcccgtcg ggagctggcc 4800

cccgaggtga tcggctcggt agtaatgctg gagattgaca accggctctg cctgcagtcg 4860

cctgagaatg atcactgctt ccccgatgcc cagagcgccg ctgactacct gggagcgttg 4920

tcagcggtgg agcgcctgga cttcccgtac ccactgcggg acgtgcgggg ggagccgctg 4980

gagcctccag aacccagcgt cccgctgctg ccactgctag tggcgggcgc tgtcttgctg 5040

ctggtcattc tcgtcctggg tgtcatggtg gcccggcgca agcgcgagca cagcaccctc 5100

tggttccctg agggcttctc actgcacaag gacgtggcct ctggtcacaa gggccggcgg 5160

gaacccgtgg gccaggacgc gctgggcatg aagaacatgg ccaagggtga gagcctgatg 5220

ggggaggtgg ccacagactg gatggacaca gagtgcccag aggccaagcg gctaaaggta 5280

gaggagccag gcatgggggc tgaggaggct gtggattgcc gtcagtggac tcaacaccat 5340

ctggttgctg ctgacatccg cgtggcacca gccatggcac tgacaccacc acagggcgac 5400

gcagatgctg atggcatgga tgtcaatgtg cgtggcccag atggcttcac cccgctaatg 5460

ctggcttcct tctgtggggg ggctctggag ccaatgccaa ctgaagagga tgaggcagat 5520

gacacatcag ctagcatcat ctccgacctg atctgccagg gggctcagct tggggcacgg 5580

actgaccgta ctggcgagac tgctttgcac ctggctgccc gttatgcccg tgctgatgca 5640

gccaagcggc tgctggatgc tggggcagac accaatgccc aggaccactc aggccgcact 5700

cccctgcaca cagctgtcac agccgatgcc cagggtgtct tccagattct catccgaaac 5760

cgctctacag acttggatgc ccgcatggca gatggctcaa cggcactgat cctggcggcc 5820

cgcctggcag tagagggcat ggtggaagag ctcatcgcca gccatgctga tgtcaatgct 5880

gtggatgagc ttgggaaatc agccttacac tgggctgcgg ctgtgaacaa cgtggaagcc 5940

actttggccc tgctcaaaaa tggagccaat aaggacatgc aggatagcaa ggaggagacc 6000

cccctattcc tggccgcccg cgagggcagc tatgaggctg ccaagctgct gttggaccac 6060

tttgccaacc gtgagatcac cgaccacctg gacaggctgc cgcgggacgt agcccaggag 6120

agactgcacc aggacatcgt gcgcttgctg gatcaaccca gtgggccccg cagccccccc 6180

ggtccccacg gcctggggcc tctgctctgt cctccagggg ccttcctccc tggcctcaaa 6240

gcggcacagt cggggtccaa gaagagcagg aggccccccg ggaaggcggg gctggggccg 6300

caggggcccc gggggcgggg caagaagctg acgctggcct gcccgggccc cctggctgac 6360

agctcggtca cgctgtcgcc cgtggactcg ctggactccc cgcggccttt cggtgggccc 6420

cctgcttccc ctggtggctt cccccttgag gggccctatg cagctgccac tgccactgca 6480

gtgtctctgg cacagcttgg tggcccaggc cgggcgggtc tagggcgcca gccccctggg 6540

aggatgtgta ctcagcctgg gcctgctgaa ccctgtggct gtgcccctcg attgggcccg 6600

gctgccccca cctgcccctc caggcccctc gttcctgctg ccactggcgc cgggacccca 6660

gctgctcaac ccagggaccc ccgtctcccc gcaggagcgg cccccgcctt acctggcagt 6720

cccaggacat ggcgaggagt acccggcggc tggggcacac agcagccccc caaaggcccg 6780

cttcctgcgg gttcccagtg agcaccctta cctgacccca tcccccgaat cccctgagca 6840

ctgggccagc ccctcacctc cctccctctc agactggtcc gaatccacgc ctagcccagc 6900

cactgccact ggggccatgg ccaccaccac tggggcactg cctgcccagc cacttccctt 6960

gtctgttccc agctcccttg ctcaggccca gacccagctg gggccccagc cggaagttac 7020

ccccaagagg caagtgttgg cctgagacgc tcgtcagttc ttagatcttg ggggcctaaa 7080

gagacccccg tcctgcctcc tttctttctc tgtctcttcc ttccttttag tctttttcat 7140

cctcttctct ttccaccaac cctcctgcat ccttgccttg caagcgtgac cgagataggt 7200

catcagccca gggcttcagt cttcctttat ttataatggg tgggggctac cacccaccct 7260

ctcagtcttg tgaagagtct gggacctcct tcttccccac ttctctcttc cctcattcct 7320

ttctctctcc ttctggcctc tcatttcctt acactctgac atgaatgaat tattattatt 7380

tttctttttc ntttgttttt ttacattttg tatagaaaca aattcattta aacaaactta 7440

ttattattat tttttacaaa atatatatat ggagatgctc cctccccctg tgaacccccc 7500

agtgcccccg tggggctgag tctgtgggcc cattcggcca agctggattc tgtgtaccta 7560

gtacacaggc atgactggga tcccgtgtac cgagtacacg acccaggtat gtaccaagta 7620

ggcacccttg ggcgcaccca ctggggccag gggtcggggg agtgttggga gcctcctccc 7680

caccccacct ccctcacttc actgcattcc agattggaca tgttccatag ccttgctggg 7740

gaagggccca ctgccaactc cctctgcccc agccccaccc ttggccatct ccctttggga 7800

actagggggc tgctggtggg aaatgggagc cagggcagat gtatgcattc ctttatgtcc 7860

ctgtaaatgt gggactacaa gaagaggagc tgcctgagtg gtactttctc ttcctggtaa 7920

tcctctggcc cagccttatg gcagaataga ggtattttta ggctattttt gtaatatggc 7980

ttctggtcaa aatccctgtg tagctgaatt cccaagccct gcattgtaca gccccccact 8040

cccctcacca cctaataaag gaatagttaa cactcagtgt tgttggtctg tgtctaggta 8100

aggtggggag tggtggcagt gggacttcta tctcccccac ccagggctaa cttgagctcc 8160

catcttgggg taaatacatt tgacttgcca gtctacttat gcttcctctt ttggcagatg 8220

actaccgatt ggattagtgg ttgtcanctg acttaag 8257

66

gggagccggc cgtggtggct ccgtgcgtcc gagcgtccgt ccgcgccgtc ggccatggcc 60

aagcgctcca ggggccccgg gcgccgctgc ctgttggcgc tcgtgctgtt ctgcgcctgg 120

gggacgctgg ccgtggtggc ccagaagccg ggcgcagggt gtccgagccg ctgcctgtgc 180

ttccgcacca ccgtgcgctg catgcatctg ctgctggagg ccgtgcccgc cgtggcgccg 240

cagacctcca tcctagatct tcgctttaac agaatcagag agatccaacc tggggcattc 300

aggcggctga ggaacttgaa cacattgctt ctcaataata atcagatcaa gaggatacct 360

agtggagcat ttgaagactt ggaaaattta aaatatctct atctgtacaa gaatgagatc 420

cagtcaattg acaggcaagc atttaaggga cttgcctctc tagagcaact atacctgcac 480

tttaatcaga tagaaacttt ggacccagat tcgttccagc atctcccgaa gctcgagagg 540

ctatttttgc ataacaaccg gattacacat ttagttccag ggacatttaa tcacttggaa 600

tctatgaaga gattgcgact ggactcaaac acacttcact gcgactgtga aatcctgtgg 660

ttggcggatt tgctgaaaac ctacgcggag tcggggaacg cgcaggcagc ggccatctgt 720

gaatatccca gacgcatcca gggacgctca gtggcaacca tcaccccgga agagctgaac 780

tgtgaaaggc cccggatcac ctccgagccc caggacgcag atgtgacctc ggggaacacc 840

gtgtacttca cctgcagagc cgaaggcaac cccaagcctg agatcatctg gctgcgaaac 900

aataatgagc tgagcatgaa gacagattcc cgcctaaact tgctggacga tgggaccctg 960

atgatccaga acacacagga gacagaccag ggtatctacc agtgcatggc aaagaacgtg 1020

gccggagagg tgaagacgca agaggtgacc ctcaggtact tcgggtctcc agctcgaccc 1080

acttttgtaa tccagccaca gaatacagag gtgctggttg gggagagcgt cacgctggag 1140

tgcagcgcca caggccaccc cccgccgcgg atctcctgga cgagaggtga ccgcacaccc 1200

ttgccagttg acccgcgggt gaacatcacg ccttctggcg ggctttacat acagaacgtc 1260

gtacaggggg acagcggaga gtatgcgtgc tctgcgacca acaacattga cagcgtccat 1320

gccaccgctt tcatcatcgt ccaggctctt cctcagttca ctgtgacgcc tcaggacaga 1380

gtcgttattg agggccagac cgtggatttc cagtgtgaag ccaagggcaa cccgccgccc 1440

gtcatcgcct ggaccaaggg agggagccag ctctccgtgg accggcggca cctggtcctg 1500

tcatcgggaa cacttagaat ctctggtgtt gccctccacg accagggcca gtacgaatgc 1560

caggctgtca acatcatcgg ctcccagaag gtcgtggccc acctgactgt gcagcccaga 1620

gtcaccccag tgtttgccag cattcccagc gacacaacag tggaggtggg cgccaatgtg 1680

cagctcccgt gcagctccca gggcgagccc gagccagcca tcacctggaa caaggatggg 1740

gttcaggtga cagaaagtgg aaaatttcac atcagccctg aaggattctt gaccatcaat 1800

gacgttggcc ctgcagacgc aggtcgctat gagtgtgngg cccggaacac cattgggtcg 1860

gcctcggtga gcatggtgct cagtgtgaat gttcctgacg tcagtcgaaa tggagatccg 1920

tttgtagcta cctccatcgt ggaagcgatt gcgactgttg acagagctat aaactcaacc 1980

cgaacacatt tgtttgacag ccgtcctcgt tctccaaatg atttgctggc cttgttccgg 2040

tatccgaggg atccttacac agttgaacag gcacgggcgg gagaaatctt tgaacggaca 2100

ttgcagctca ttcaggagca tgtacagcat ggcttgatgg tcgacctcaa cggaacaagt 2160

taccactaca acgacctggt gtctccacag tacctgaacc tcatcgcaaa cctgtcgggc 2220

tgtaccgccc accggcgcgt gaacaactgc tcggacatgt gcttccacca gaagtaccgg 2280

acgcacgacg gcacctgtaa caacctgcag caccccatgt ggggcgcctc gctgaccgcc 2340

ttcgagcgcc tgctgaaatc cgtgtacgag aatggcttca acacccctcg gggcatcaac 2400

ccccaccgac tgtacaacgg gcacgccctt cccatgccgc gcctggtgtc caccaccctg 2460

atcgggacgg agaccgtcac acccgacgag cagttcaccc acatgctgat gcagtggggc 2520

cagttcctgg accacgacct cgactccacg gtggtggccc tgagccaggc acgcttctcc 2580

gacggacagc actgcagcaa cgtgtgcagc aacgaccccc cctgcttctc tgtcatgatc 2640

ccccccaatg actcccgggc caggagcggg gcccgctgca tgttcttcgt gcgctccagc 2700

cctgtgtgcg gcagcggcat gacttcgctg ctcatgaact ccgtgtaccc gcgggagcag 2760

atcaaccagc tcacctccta catcgacgca tccaacgtgt acgggagcac ggagcatgag 2820

gcccgcagca tccgcgacct ggccagccac cgcggcctgc tgcggcaggg catcgtgcag 2880

cggtccggga agccgctgct ccccttcgcc accgggccgc ccacggagtg catgcgggac 2940

gagaacgaga gccccatccc ctgcttcctg gccggggacc accgcgccaa cgagcagctg 3000

ggcctgacca gcatgcacac gctgtggttc cgcgagcaca accgcattgc cacggagctg 3060

ctcaagctga acccgcactg ggacggcgac accatctact atgagaccag gaagatcgtg 3120

ggtgcggaga tccagcacat cacctaccag cactggctcc cgaagatcct gggggaggtg 3180

ggcatgagga cgctgggaga gtaccacggc tacgaccccg gcatcaatgc tggcatcttc 3240

aacgccttcg ccaccgcggc cttcaggttt ggccacacgc ttgtcaaccc actgctttac 3300

cggctggacg agaacttcca gcccattgca caagatcacc tcccccttca caaagctttc 3360

ttctctccct tccggattgt gaatgagggc ggcatcgatc cgcttctcag ggggctgttc 3420

ggggtggcgg ggaaaatgcg tgtgccctcg cagctgctga acacggagct cacggagcgg 3480

ctgttctcca tggcacacac ggtggctctg gacctggcgg ccatcaacat ccagcggggc 3540

cgggaccacg ggatcccacc ctaccacgac tacagggtct actgcaatct atcggcggca 3600

cacacgttcg aggacctgaa aaatgagatt aaaaaccctg agatccggga gaaactgaaa 3660

aggttgtatg gctcgacact caacatcgac ctgtttccgg cgctcgtggt ggaggacctg 3720

gtgcctggca gccggctggg ccccaccctg atgtgtcttc tcagcacaca gttcaagcgc 3780

ctgcgagatg gggacaggtt gtggtatgag aaccctgggg tgttctcccc ggcccagctg 3840

actcagatca agcagacgtc gctggccagg atcctatgcg acaacgcgga caacatcacc 3900

cgggtgcaga gcgacgtgtt cagggtggcg gagttccctc acggctacgg cagctgtgac 3960

gagatcccca gggtggacct ccgggtgtgg caggactgct gtgaagactg taggaccagg 4020

gggcagttca atgccttttc ctatcatttc cgaggcagac ggtctcttga gttcagctac 4080

caggaggaca agccgaccaa gaaaacaaga ccacggaaaa tacccagtgt tgggagacag 4140

ggggaacatc tcagcaacag cacctcagcc ttcagcacac gctcagatgc atctgggaca 4200

aatgacttca gagagtttgt tctggaaatg cagaagacca tcacagacct tcagaacaca 4260

gataaagaaa cttgaatcac ggctcagtac cacagagtgc gtggatgccg ggggcgaatc 4320

tcacgccaac aacaccaagt ggaaaaaaga tgcatgcacc atttgtgaat gcaaagacgg 4380

gcaggtcacc tgcttcgtgg aagcttgccc ccctgccacc tgtgctgtcc ccgtgaacat 4440

cccaggggcc tgctgtccag tctgcttaca gaagagggcg gaggaaaagc cctaggctcc 4500

tgggaggctc ctcagagttt gtctgctgtg ccatcgtgag atcgggtggc cgatggcagg 4560

gagctgcgga ctgcagacca ggaaacaccc agaactcgtg acatttcatg acaacgtcca 4620

gctggtgctg ttacagaagg cagtgcagga ggcttccaac cagagcatct gcggagaagg 4680

aggcacagca ggtgcctgaa gggaagcagg caggagtcct agcttcacgt tagacttctc 4740

aggtttttat ttaattcttt taaaatgaaa aattggtgct actattaaat tgcacagttg 4800

aatcatttag gcgcctaaat tggttttgcc tcccaacacc atttcttttt aaataaagca 4860

ggatacctct atatgtcagc cttgccttgt tcagatgcca ggagccggca gacctgtcac 4920

ccgcaggtgg ggtgagtctt ggagctgcca gaggggctca ccgaaatcgg ggttccatca 4980

caagctatgt ttaaaaagaa aattggtgtt tggcaaacgg aacagaacct ttgatgagag 5040

cgttcacagg gacactgtct gggggtgcag tgcaagcccc cggcctcttc cctgggaacc 5100

tctgaactcc tccttcctct gggctctctg taacatttca ccacacgtca gcatctaatc 5160

ccaagacaaa cattcccgct gctcgaagca gctgtatagc ctgtgactct ccgtgtgtca 5220

gctccttcca cacctgatta gaacattcat aagccacatt tagaaacaga tttgctttca 5280

gctgtcactt gcacacatac tgcctagttg tgaaccaaat gtgaaaaaac ctccttcatc 5340

ccattgtgta tctgatacct gccgagggcc aagggtgtgt gttgacaacg ccgctcccag 5400

ccggccctgg ttgcgtccac gtcctgaaca agagccgctt ccggatggct cttcccaagg 5460

gaggaggagc tcaagtgtcg ggaactgtct aacttcaggt tgtgtgagtg cgttaaaaaa 5520

aaaaaaanaa aaaagaatcc ctatacctca tttgtatttt taaaatgcgt gatgttttat 5580

gaaattgtgt ccatttttta ggtattagat atggcagaaa aaccatttcc actatgcaaa 5640

gttcttttag acgtcagtga aaatcaactc tcatacctca tggtctctct ttaattgacc 5700

aaaaccttcc atttttctct aaatacaaag cgatctgtgt tctgagcaac ctttccccga 5760

acacacagct tcagtgcagc acgctgacct gagtatccac catgtgccag gcacagtgct 5820

gggcacacga ggcaccaagg tccgggccac ctgcccgcag caaggcccag ctgaggtggt 5880

ggagggagcc cctgaggtca ggggccgttt cggttcaggg tggcaggtgt ccagcactgg 5940

ggtatggcgt cgaggcttcc atggggtggg ggaggccagc ttccttctga caggatgggc 6000

gcatacagtg cctggtgtga tttgtgcaca acccgtgttc caggtgcaca tcctcccaag 6060

gagacaccca gacccttcca gcacgggccg gccaagttgc tgcggcggag gcagcatttc 6120

agctgtgagg aaggtcattg gattcatgtg ttttatctgt aaaaatggtt gtcttaactt 6180

cttaacctca tattggtaag tgattgataa aaattggttg gtgtttcatg acatgtggac 6240

ttcttttgaa atagcaagtc aaatgtagtg accaaattgt ggaagagatt tctgtcaaat 6300

aggaaatgtg taagttcgtc taaaagctga tggttatgta agttgctcag gcactcagat 6360

gacagcagat tctgggttct gggagtgttc tgtgcctctt acatgccctg gaggcctcat 6420

ggtctcagtg ctgaggcggc acacctgtag cacacctgcg taatgtgcgg tctgggccag 6480

tcacaaggaa ttgtgttgtc taagccaaag ggggaagctg actgtgattt accaaaaaaa 6540

attctgtaat tcaaaccaaa atgtctgcgg aatcaccagt ttgatactct ctgtaatcag 6600

aacagtgggc agtgcctggg tgaacgtgtc tagcagccac tgtgcgggat cgctgtaaca 6660

ggagtggaat gtacatattt atttactttt ctaactgctc caacagccaa atgccttttt 6720

tatgaccatt gtattcagtt cattaccaaa gaaatgtttg cactttgtaa tgatgccttt 6780

cagttcaaat aaatgggtca cattttcaaa tgga 6814

67

tcggtgagct acccctctct ttggccgctt gcaccaagca gtgggatgtg gtaagctacc 60

tcctggagaa cccacaccag cccgccagcc tgccaggcca ctgactccca gggcaacaca 120

gtcctgcatg ccctagtgat gatctcggac aactcagctg agaacattgc actggtgacc 180

agcatgtatg atgggctcct ccaagctggg gcccgcctct gccctaccgt gcagcttgag 240

gacatccgca acctgcagga tctcacgcct ctgaagctgg ccgccaagga gggcaagatc 300

gagattttca ggcacatcct gcagcgggag ttttcaggac tgagccacct ttcccgaaag 360

ttcaccgagt ggtgctatgg gcctgtccgg gtgtcgctgt atgacctggc ttctgtggac 420

agctgtgagg agaactcagt gctggagatc attgcctttc attgcaagag cccgcaccga 480

caccgaatgg tcgttttgga gcccctgaac aaactgctgc aggcgaaatg ggatctgctc 540

atccccaagt tcttcttaaa cttcctgtgt aatctgatct acatgttcat cttcaccgct 600

gttgcctacc atcagcctac cctgaagaag caggccgccc ctcacctgaa agcggaggtt 660

ggaaactcca tgctgctgac gggccacatc cttatcctgc taggggggat ctacctcctc 720

gtgggccagc tgtggtactt ctggcggcgc cacgtgttca tctggatctc gttcatagac 780

agctactttg aaatcctctt cctgttccag gccctgctca cagtggtgtc ccaggtgctg 840

tgtttcctgg ccatcgagtg gtacctgccc ctgcttgtgt ctgcgctggt gctgggctgg 900

ctgaacctgc tttactatac acgtggcttc cagcacacag gcatctacag tgtcatgatc 960

cagaaggtca tcctgcggga cctgctgcgc ttccttctga tctacttagt cttccttttc 1020

ggcttcgctg tagccctggt gagcctgagc caggaggctt ggcgccccga agctcctaca 1080

ggccccaatg ccacagagtc agtgcagccc atggagggac aggaggacga gggcaacggg 1140

gcccagtaca ggggtatcct ggaagcctcc ttggagctct tcaaattcac catcggcatg 1200

ggcgagctgg ccttccagga gcagctgcac ttccgcggca nnnnnnnnnn nnnnnnnnnn 1260

gcctacgtgc tgctcaccta catcctgctg ctcaacatgc tcatcgccct catgagcgag 1320

accgtcaaca gtgtcgccac tgacagctgg agcatctgga agctgcagaa agccatctct 1380

gtcctggaga tggagaatgg ctattggtgg tgcaggaaga agcagcgggc aggtgtgatg 1440

ctgaccgttg gcactaagcc agatggcagc ccggatgagc gctggtgctt cagggtggag 1500

gaggtgaact gggcttcatg ggagcagacg ctgcctacgc tgtgtgagga cccgtcaggg 1560

gcaggtgtcc ctcgaactct cgagaaccct gtcctggctt cccctcccaa ggaggatgag 1620

gatggtgcct ctgaggaaaa ctatgtgccc gtccagctcc tccagtccaa ctgatggccc 1680

agatgcagca ggaggccaga ggacagagca gaggatcttt ccaaccacat ctgctggctc 1740

tggggtccca gtgaattctg gtggcaaata tatattttca ctaactcaaa 1790

68

acacacactg catgcagcac acacacacca gggacgcacc acacagagca cgcacagcac 60

acaccacaca gcgcacgcac cacacagagc acacgcggca cacacagcac acacagcgca 120

cgcaccacgc agagcacaca nggcacatgc agcatacaca ccaaacagcg catgcaccac 180

acagagcaca cgcggcacac gcagcacaca caccacacag agcacctgga gcacccacag 240

cacacacacc acgcagagta cacgcggcac acacaccaca cacagcgcat gcacaacaca 300

gagcacacac agcacatgca ccacacgtag cgcgcacact gcaggcagca cacacaccac 360

acacagcgcg tgcaccacac agagcacctg cggcacacac agcacacacc gcacgcacca 420

cacagagcac atgtggcaca cacagtgcac gcaccacaca gcacccgcgg cgcacacagc 480

acacgtggca tatggcctcc atgaccctgt gtcttgaggg caggtcctac tttttgcttt 540

gttgtgttgg agcggaattt ctcccctggc ttctattgga gtcctagatt atttaaatca 600

cttcctctgt taattgtgcc tggaattaac ctgttagatt tacttcctag cagttagttg 660

ctcagtatgg gtttctacac tattaaagca acctagcggt agtacacaag gttttgttag 720

gatagctgtg agattttttt tctctaacaa tcatcattat ttctgtgtct gctccgtttt 780

tcttcagtgt tttatatgat attaataggg gatgtctaat tttgtatctt taaaaaaact 840

ttatcaaatc tgaagcattt ttcgtgttat agcttctcta taatttttca tggatattga 900

atatttggtg ttgatattct tcactcagtt ttgaacattg agttttcttc taatgttttg 960

tgcttatgaa aaccatttct gtgtaacgtg tttaagtagc ttatttatct gaaagaactc 1020

taataatgaa aagaaataaa aagtttttca gaagcatgat catattcttc cagaagagtc 1080

aggaaccatg tgtgccagga aagggaaacg ggactgagcg tctcgtagcg aaacgcctgc 1140

tgcagacttg acgcggctcc cctccaggac gggctggcgg cacacagact gtgcacttac 1200

ctcactgccg gcctcataat agtaatcagt gtaaatggtg tttctctttc gttttgttat 1260

ttcgtggcgt acgtgttaaa gtgtgtgaaa ctacaaggcc agctagtcct ttcatcattc 1320

cctttggtgc aggttttgga gcagcaccac agggcacacc cctcgccact ctttatgggg 1380

aatttttgcc caggcaggca gaggagtcat cttggtcaca agtctccctt ttccccctcc 1440

ccagcatctt cgatcctgtc cccacccctc cagatgcatc caggggttgc aagcctgccc 1500

cccaaccagt ccccgtgagg aacagtggcc gggattgtcc cagggcccct tccagcaggg 1560

ggacctcctg acttgagagt ccccaaagcc ttcccagggc agctagaatc tgcctggaga 1620

gaagggatct tgtccccaag ggttagaggc agtaaactaa tagcaaggac agctgccttt 1680

agcaattgtg tgtgtcgcat ggccggtccc tgcatttttc ttcagttcca aagctgcact 1740

ggcattttta tggtcatctc tggagtccct ttgattcaag aaattatacc tctaggatgc 1800

caactaaacg aacaacaaac agaaactcca cctgtttgct agcataacag gcgtgaaggc 1860

ggcagtgtcg ccggcgtcct tccgcggaag cccagtgtgt gcagacagca cggggtggcg 1920

ctgctctcag gtgctctggc tgcttgggtt cctggcatgc tgatttgtga cttaagatta 1980

aaatcacatt gccagggatt accacgcaac cacgaccttg gctgctcctc cagaaaccgt 2040

ggtcgcgctc actgcagatt ggagaacagg tgcatctcgt agctcttctt tggaaacaaa 2100

agaagccacc agctgaggaa gatgctcacc ggtcaccgtc cctttattta tgcccagcga 2160

tgacctctct aacaaggtgc agagcttagc tgattggtga acagtgattg gtttccgctt 2220

tgttcacagt ggctaagttc tgcacctgaa gagaaggtga gatggggaca gttaagttgg 2280

agccgctggg gcagaggccg ttgctgacgg gccggccgct gctgcacagt cagcttgggt 2340

gcggacgcga tcctggagga tgagagacca cttgacccca aggatgcact gtctcctgct 2400

gggaatgcta gccatgtact gagtccttaa gtctgtccac agaaacatcc actaatcgga 2460

catctgtctg aaaggtcaaa tgtattgaaa gttgcaaaaa ttcttcttac aaaaaactaa 2520

aaccaaatgc atcacctaag tcgtgtgaaa tcatgtggta gctcatggct gtgagcgggg 2580

cggggcgggg ctttcggagg agctcctgtt gttctgggcg cggtgaactc tctcttgtat 2640

ttgcagtcca ggccttcgcg tctcctgcgc cagcagacgg tgcccacgga gctcccagct 2700

gaggcgctgc ttctccgggc tgtcgattgg acccgccctc cggtgcctac tgagctgata 2760

tcagttctca ttttacacac tggctcagtt cagcaggaac aggagtcgag cccttgagca 2820

aaaagccttc gtgtctgtaa gtgcccgagg ctcaggagag ctgggggctc ccactcgcgg 2880

cagacaggcc cgcgtaccac cctgcgtcca ccccggcccg gcggcagcaa cggtgccagt 2940

catctgcatg tgctcctgcg gcgtgggggt ttgtagactt ggaaaaccct gttggcagaa 3000

agttaagagc tcccaggcct gaaggcagga cacagtgcca gcagggggcc gtttgccccc 3060

atgtgtaagg gaggcagggc ccagctctcc cacggcgagg tgagctgaga ctttctgaga 3120

atagttagag tgggtgcgtg tctgaaatgg gtactcctag cagctattgt gtacgcaaag 3180

cctgagtaca gcctgctggt gtcatggcca cgtgtgagca ggccagcgtc acacggctcg 3240

ctgtgacccg tcccggagac tgaaatgggc ctgggtcttc tccttgtcct gtgattaaag 3300

tcctctcttg aaagtggaga gcaaaggcac acagaggtgc gcgctcacaa gaattcctcc 3360

cggtgactgg gtaatcaatg ttactgctgt ttcctttgca ggaaagacca cagcaagatt 3420

ctttcattcg tctcctccta gcctggggga ccaggctcga actgaccctg gacatcaaag 3480

gagggattat gtggctgcta aagccatcgg cccacagccc tgttcacgtc ttggtgcttc 3540

tctttcccag aggctggtcc cagccaggca cacacaaaag gcagattctc gtaaacgcag 3600

cctccctccc tggaggctgc ctcctgccct ggatctggag tggagctgct ctgagatttt 3660

gagttcttct gcagagatga ttaaatatat ccaagagaca ttggaaaacc tgctgaacat 3720

tttacattgg tctgctcagc acatggctgg atgcggatat ttctataatt ccagaaagtc 3780

acacagctcc tctgtatgag accagtgggc gccatttaaa agaacaggat gagaatctaa 3840

gatatattat taataaatgt aatggatttt ttttttgtaa aa 3882

69

cagggcagcg acgcgactct ggtgcgggcc gtcttcttcc ccccganctg ggcgtgcgcg 60

gccgcaatga actgggagct gctgctgtgg ctgctggtgc tgtgcgcgct gctcctgctc 120

ttggtgcagc tgctgcgctt cctgagggct gacggcgacc tgacgctact atgggccgag 180

tggcagggac gacgcccaga atgggagctg actgatatgg tggtgtgggt gactggagcc 240

tcgagtggaa ttggtgagga gctggcttac cagttgtcta aactaggagt ttctcttgtg 300

ctgtcagcca gaagagtgca tgagctggaa agggtgaaaa gaagatgcct agagaatggc 360

aatttaaaag aaaaagatat acttgttttg ccccttgacc tgaccgacac tggttcccat 420

gaagcggcta ccaaagctgt tctccaggag tttggtagaa tcgacattct ggtcaacaat 480

ggtggaatgt cccagcgttc tctgtgcatg gataccagct tggatgtcta cagaaagcta 540

atagagctta actacttagg gacggtgtcc ttgacaaaat gtgttctgcc tcacatgatc 600

gagaggaagc aaggaaagat tgttactgtg aatagcatcc tgggtatcat atctgtacct 660

ctttccattg gatactgtgc tagcaagcat gctctccggg gtttttttaa tggccttcga 720

acagaacttg ccacataccc aggtataata gtttctaaca tttgcccagg acctgtgcaa 780

tcaaatattg tggagaattc cctagctgga gaagtcacaa agactatagg caataatgga 840

gaccagtccc acaagatgac aaccagtcgt tgtgtgcggc tgatgttaat cagcatggcc 900

aatgatttga aagaagtttg gatctcagaa caacctttct tgttagtaac atatttgtgg 960

caatacatgc caacctgggc ctggtggata accaacaaga tggggaagaa aaggattgag 1020

aactttaaga gtggtgtgga tgcagactct tcttatttta aaatctttaa gacaaaacat 1080

gactgaaaag agcacctgta cttttcaagc cactggaggg agaaatggaa aacatgaaaa 1140

cagcaatctt cttatgcttc tgaataatca aagactaatt tgtgatttta ctttttaata 1200

gatatgactt tgcttccaac atggaatgaa ataaaaaata aaatcacaaa ttagtctttg 1260

attattcaga agcataagaa gattgctgtt ttcatgtttt ccatttctcc ctccagtggc 1320

ttgaaaagta caggtgctct tttcagtcat gttttgtctt aaagatttta aaataagaag 1380

agtctgcatc cacaccactc ttaaagttct caatcctttt cttccccatc ttgttggtta 1440

tccaccaggc ccaggttggc atgtattgcc acaaatatgt tact 1484

70

caaaatttgg cgtgatacat tcctagtgga aagaggcaaa tttctacgta agaaggaaga 60

atccagcaag aatatccaac agtcaaatca cttgcccaaa tatgaacggg tcaaagaact 120

atgccagcag gccaggtacc agacagcctg tgaacaaccg gggcagaagt ggcaatgcat 180

tgaggataca tctggcaagc ttcgaattca caagtgtaaa ggacccagtg acctgctcac 240

agtccggcag agcacgcgga acctctacgc tcgcggcttc catgacaaag acaaagagtg 300

cagttgtagg gagtctggtt accgtgccag cagaagccaa agaaagagtc aacggcaatt 360

cttgagaaac caggggactc caaagtacaa gcccagattt gtccatactc ggcagacacg 420

ttccttgtcc gtcgaatttg aaggtgaaat atatgacata aatctggaag aagaagaaga 480

attgcaagtg ttgcaaccaa gaaacattgc taagcgtcat gatgaaggcc acaaggggcc 540

aagagatctc caggcttcca gtggtggcaa caggggcagg atgctggcag atagcagcaa 600

cgccgtgggc ccacctacca ctgtccgagt gacacacaag tgttttattc ttcccaatga 660

ctctatccat tgtgagagag aactgtacca atcggccaga gcgtggaagg accataaggc 720

atacattgac aaagagattg aagctctgca agataaaatt aagaatttaa gagaagtgag 780

aggacatctg aagagaagga agcctgagga atgtagctgc agtaaacaaa gctattacaa 840

taaagagaaa ggtgtaaaaa agcaagagaa attaaagagc catcttcacc cattcaagga 900

ggctgctcag gaagtagata gcaaactgca actttttcaa ggagaacaac cgtaggagga 960

agaaggagag gaaggagaag agacggcaga ggaaggggga agagtgcagc ctgcctgggc 1020

ctcacttgct tcacgcatga caacaaccac tggcagacag ccccgttctg gaacctggga 1080

tctttctgtg cttgcacgag ttctaacaat aacacctact ggtgtttgcg tacagttaat 1140

gagacgcata attttctttt ctgtgagttt gctactggct ttttggagta ttttgatatg 1200

aatacagatc cttatcagct cacaaataca gtgcacacgg tagaacgagg cattttgaat 1260

cagctacacg tacaactaat ggagctcaga agctgtcaag gatataagca gtgcaaccca 1320

agacctaaga atcttgatgt tggaaataaa gatggaggaa gctatgacct acacagagga 1380

cagttatggg atggatggga aggttaatca gccccgtctc actgcagaca tcaactggca 1440

aggcctagag gagctacaca gtgtgaatga aaacatctat gagtacagac aaaactacag 1500

acttagtctg gtggactgga ctaattactt gaaggattta gatagagtat ttgcactgcc 1560

tgaagagtca ctatgagcaa aataaaacaa ataagactca aactgctcaa agtgacgggt 1620

tcttggttgt ctctgctgag cacgctgtgt caatggagat ggcctctgct gactcagatg 1680

aagacccaag gcataaggtt gggaaaacac ctcatttgac cttgccagct gaccttcaaa 1740

ccctgcattt gaaccgacca acattggttt ttctccagag agtaaacttg aatggaataa 1800

cgacattcca gaagttaatc atttgaattc tgaacactgg agaaaaaccg aaaaatggac 1860

ggggcatgaa gagactaatc atctggaaac cgatttcagt ggcgatggca tgacagagct 1920

agagctcggg cccagcccca ggctgcagcc cattcgcagg cacccgaaag aacttcccca 1980

gtatggtggt cctggaaagg acatttttga agatcaacta tatcttcctg tgcattccga 2040

tggaatttca gttcatcaga tgttcaccat ggccaccgca gaacaccgaa gtaattccag 2100

catagcgggg aagatgttga ccaaggtgga gaagaatcac gaaaaggaga agtcacagca 2160

cctagaaggc agcacctcct cttcactctc ctctgattag atgaaactgt taccttaccc 2220

taaacacagt atttcttttt aactttttta tttgtaaact aataaaggta atcacagcca 2280

ccaacattcc aagctaccct gggtaccttt gtgcagtaga agctagtgag catgtgagca 2340

agcggtgtgc acacggagac tcatcgttat aatttactat ctgccaagag tagaaagaaa 2400

ggctggggat atttgggttg gcttggtttt gattttttgc ttgtttgttt gttttgtact 2460

aaaacagtat tatcttttga atatcgtagg gacataagta tatacatgtt atccaatcaa 2520

gatggctaga atggtgcctt tctgagtgtc taaaacttga cacccctggt aaatctttca 2580

acacacttcc actgcctgcg taatgaagtt ttgattcatt tttaaccact ggaatttttc 2640

aatgccgtca ttttcagtta gatgattttg cactttgaga ttaaaatgcc atgtctattt 2700

gattagtctt atttttttat ttttacaggc ttatcagtct cactgttggc tgtcattgtg 2760

acaaagtcaa ataaaccccc aaggacgaca cacagtatgg atcacatatt gtttgacatt 2820

aagcttttgc cagaaaatgt tgcatgtgtt ttacctcgac ttgctaaaat cgattagcag 2880

aaaggcatgg ctaataatgt tggtggtgan nnnnnnnnnn nnnnnnnnnn nnatgaagat 2940

tgcctgctct ctctgtgcct agcctcaaag cgttcatcat acatcatacc tttaagattg 3000

ctatattttg ggttattttc ttgacaggag aaaaagatct aaagatcttt tattttcatc 3060

ttttttggtt ttcttggcat gactaagaag cttaaatgtt gataaaatat gactagtttt 3120

gaatttacac caagaacttc tcaataaaag aaaatcatga atgctccaca atttcaacat 3180

accacaagag aagttaattt cttaacattg tgttctatga ttatttgtaa gaccttcacc 3240

aagttctgat atcttttaaa gacatagttc aaaattgctt ttgaaaatct gtattcttga 3300

aaatatcctt gttgtgtatt aggtttttaa ataccagcta aaggattacc tcactgagtc 3360

atcagtaccc tcctattcag ctccccaaga tgatgtgttt ttgcttaccc taagagaggt 3420

tttcttctta tttttagata attcaagtgc ttagataaat tatgttttct ttaagtgttt 3480

atggtaaact cttttaaaga aaatttaata tgttatagct gaatcttttt ggtaacttta 3540

aatctttatc atagactctg tacatatgtt caaattagct gcttgcctga tgtgtgtatc 3600

atcggtggga tgacagaaca aacatattta tgatcatgaa taatgtgctt tgtaaaaaga 3660

tttcaagtta ttaggaagca tactctgttt tttaatcatg tataatattc catgatactt 3720

ttatagaaca attctggctt caggaaagtc tagaagcaat atttcttcaa ataaaaggtg 3780

tttaaacttt ncanaaataa aaatacaaat aananaaaaa cttaaanaag gtttgaaaaa 3840

ganatgtatn nggggatctn aaagtgttta c 3871

71

cctgcctcaa tgctgagcag aaccagcacc tccgggcctc cctcagccgc ctgcatcggg 60

tggcacagta tgcccgggcc cagcacgtgc ggctcctggt ggatgcggag tacacctcac 120

tgaaccctgc gctctcgctg ctggtggctg ccctggctgt gcgctggaac agcccgggtg 180

aaggcgggcc ctgggtgtgg aacacctacc aggcctgtct aaaggacaca ttcgagcggc 240

tggggaggga tgcagaggct gcgcacaggg ccggcctggc cttcggagtg aagctggtac 300

gaggtgcata tctggacaag gagagagcgg tggcccagct ccatgggatg gaagacccca 360

ctcagcctga ctatgaggcc accagtcaga gttacagccg ctgcctggaa ctgatgctga 420

cgcacgtggc ccgccatggc cccatgtgcc acctcatggt ggcttcccac aatgaggaat 480

ctgttcgcca ggcaaccaag cgggcaggcc ggctatgtag tgtataagtc cattccctat 540

ggctccttgg aggaggtaat cccctacctg atccggaggg cccaggagaa ccggagcgtg 600

cttcagggtg cccgcaggga acaggagctg ntcagcnaag aactgtggcg gcggctgctg 660

ccaggatgcc gaaggatacc ccactagcac ccctgagggg gtcatgtggt caataaaagt 720

ccttaggtgc tgcct 735

72

ggtgggctgg tggaggcggg gtcgagatgg cggcgccttt gaggattcag agcgactggg 60

cgcaagcctc aggaaggatg aaggggaggc ctggctgagc tgtcatcccc cagtggaagc 120

agcctgaggc tctcatcaga agcagatnct ggtgccatgc ttcttgtaca gtctgcagaa 180

ccggaaacca tctttgtatg gcagcctgac ttgtcaagga attggcctag atggcatccc 240

agaggttaca gcttcagaag gatttactgt gaatgaaata aacaagaaaa gcattcatat 300

ttcatgtcca aaggaaaatg catcttctaa gtttttggca ccatatacta ctttttccag 360

aattcataca aagagtataa catgcctgga catttccagc agaggaggtc ttggtgtgtc 420

ttctagtact gacgggacca tgaaaatctg gcaggcttcc aatggagaac tcaggagagt 480

attggaagga catgtgtttg atgtgaattg ttgcaggttt ttcccatcag gccttgtggt 540

cctgagtggg ggaatggatg cccagctgaa gatatggtca gctgaagatg ctagctgccg 600

tggtgacctt caaaggtcac aaaggaggta tcctgggata cagccatcgt tgatcggggg 660

aggaatgtgg tgtctgcttc tcgagatggg acagcacgac tttgggattg tgggcgctca 720

ggctgcttgg gagtccttgc agattgtggt tcttctatca atggagtggc ggtgggtgct 780

gctgacaact ccataaacct tgggctcccc tgagcagatg cccagtgaac gggaggttgg 840

aacagaggcc aaaatgctgc tcttggcccg ggaagataag aaacttcagt gcttgggact 900

acagagcagg cagctggtgt tcctctttat tggctcagac gctttcaact gctgtacttt 960

tctctctggc ttcttgctat tggctgggac tcaagatgga aacatttatc agctggatgt 1020

gaggagtcca agggctccgg tacaagtcat ccacagatca ggagcaccag ttctatccct 1080

gctaagtgtc agagatggat tcattgctag ccaaggtgat ggaagctgtt ttattgtcca 1140

gcaagactta gactatgtca ctgagctcac tggggctgac tgtgaccctg tgtacaaggt 1200

agccacatgg gagaagcaga tctacacatg ctgtcgagac ggtcttgtac gacgctacca 1260

gctttctgac ctctgacttc ttggaaagag cagtcccggt tagtgaaaag gtttgaccct 1320

gatcaacaat gagcagaaac atcatcagtc cttcccaagg accatggcgt ttaatgtctt 1380

gggcacccct tggaaatcac agaaagtcag ctgtactggc cgtgtggaac tctcatccca 1440

agacctactt tgaactgagt aagaaggtca ttgtgcccac tgcatttgtt ccaacttctc 1500

cttgtataaa ctcaccccag caacacaggg caaggatata gatgctttta gtttgttctt 1560

aaaccagttt tgttaaatgt ttacaaggac ctcagtacta aagcctgttc tctggaggaa 1620

ataaagaaaa tatgtttgga ggtgcctga 1649

73

ggcgttccca ctgcaccctg ggagaacgag cctttgcggg gtttctcctg gctgtcctcc 60

gaccccggcg gtctcgaaag cgacacgctg cagtgggtgg aggagcccca acgctcctgc 120

accgcgcgga gatgcgcggt actccaggcc accggtgggg tcgagcccgc aggctggaag 180

gagatgcgat gccacctgcg cgccaacggc tacctgtgca agtaccagtt tgaggtcttg 240

tgtcctgcgc cgcgccccgg ggccgcctct aacttgagct atcgcgcgcc cttccagctg 300

cacagcgccg ctctggactt cagtccacct gggaccgagg tgagtgcgct ctgccgggga 360

cagctcccga tctcagttac ttgcatcgcg gacgaaatcg gcgctcgctg ggacaaactc 420

tcgggcgatg tgttgtgtcc ctgccccggg aggtacctcc gtgctggcaa atgcgcagag 480

ctccctaaac tgcctaggac ggacttggga ggctttgcct gcgaatgtgc tacgggcttc 540

gagctgggga aggacggccg ctcttgtgtg accagtgggg aaggacagcc gacccttggg 600

gggaccgggg tgcccaccag gcgcccgccg gccactgcaa ccagccccgt gccgcagaga 660

acatggccaa tcagggtcga cgagaagctg ggagagacac cacttgtccc tgaacaagac 720

aattcagtaa catctattcc tgagattcct cgatggggat cacagagcac gatgtctacc 780

cttcaaatgt cccttcaagc cgagtgcaaa ggccactatc accccatcag ggagcgtgat 840

ttccaagttt aattctaacg acttcctctg ccactcctca ggctttcgac tcctcctctg 900

ccgtggtctt catatttgtg agcacagcag tagtagtgtt ggtgatcttg accatgacag 960

tactggggct tgtcaagctc tgctttcacg aaagcccctc ttcccagcca aggaaggagt 1020

ctatgggccc gccgggcctg gagagtgatc ctgagcccgc tgctttgggc tccagttctg 1080

cacattgcac aaacaatggg gtgaaagtcg gggactgtga tctgcgggac agagcagagg 1140

gtgccttgct ggcggagtcc cctcttggct ctagtgatgc atagggaaac aggggacatg 1200

ggcactcctg tgaacagttt ttcacttttg atgaaacggg gaaccaagag gaacttactt 1260

gtgtaactga caatttctgc agaaatcccc cttcctctaa attcccttta ctccactgag 1320

gagctaaatc agaactgcac actccttccc tgatgataga ggaagtggaa gtgcctttag 1380

gatggtgata ctgggggacc gggtagtgct ggggagagat attttcttat gtttattcgg 1440

agaatttgga gaagtgattg aacttttcaa gacattggaa acaaatagaa cacaatataa 1500

tttacattaa aaaataattt ctaccaaaat ggaaaggaaa tgttctatgt tgttcaggct 1560

aggagtatat tggttcgaaa tcccagggaa aaaaataaaa ataaaaaatt aaaggattgt 1620

tgataaccc 1629

74

gagacccaga gatcaggaga gaaggcaccg cccccacccc gcctccaaag ctaaccctcg 60

ggcttgaggg gaagaggctg actgtacgtt ccttctactc tggcaccact ctccaggctg 120

ccatggggcc cagcacccct ctcctcatct tgttcctttt gtcatggtcg ggacccctcc 180

aaggacagca gcaccacctt gtggagtaca tggaacgccg actagctgct ttagaggaac 240

ggctggccca gtgccaggac cagagtagtc ggcatgctgc tgagctgcgg gacttcaaga 300

acaagatgct gccactgctg gaggtggcag agaaggagcg ggaggcactc agaactgagg 360

ccgacaccat ctccgggaga gtggatcgtc tggagcggga ggtagactat ctggagaccc 420

agaacccagc tctgccctgt gtagagtttg atgagaaggt gactggaggc cctggggacc 480

aaaggcaagg gaagaaggaa tgagaagtac gatatggtga cagactgtgg ctacacaatc 540

tctcaagtga gatcaatgaa gattctgaag cgatttggtg gcccagctgg tctatggacc 600

aaggatccac tggggcaaac agagaagatc tacgtgttag atgggacaca gaatgacaca 660

gcctttgtct tcccaaggct gccgtgactt cacccttgcc atggctgccc ggaaagcttc 720

ccgagtccgg gtgcccttcc cctgggtagg cacagggcag ctggtatatg gtggctttct 780

ttattttgct cggaggcctc ctggaagacc tggtggaggt ggtgagatgg agaacacttt 840

gcagctaatc aaattccacc tgggcaaacc gaacagtggt ggacagctca gtattcccag 900

cagaggggct gatccccccc tacggcttga cagcagacac ctacatcgac ctggcagctg 960

atgaggaagg tctttgggct gtctatgcca cccgggagga tgacaggcac ttgtgtctgg 1020

ccaagttaga tccacagaca ctggacacag agcagcagtg ggacacacca tgtcccagag 1080

agaatgctga ggctgccttt gtcatctgtg ggaccctcta tgtcgtctat aacacccgtc 1140

ctgccagtcg ggcccgcatc cagtgctcct ttgatgccag cggcaccctg acccctgaac 1200

gggcagcact cccttatttt ccccgcagat atggtgccca tgccagcctc cgctataacc 1260

cccgagaacg ccagctctat gcctgggatg atggctacca gattgtctat aagctggaga 1320

tgaggaagaa agaggaggag gtttgaggag ctagccttgt tttttgcatc tttctcactc 1380

ccatacattt atattatatc cccactaaat ttcttgttcc tcattcttca aatgtgggcc 1440

agttgtggct caaatcctct atatttttag ccaatggcaa tcaaattctt tcagctcctt 1500

tgtttcatac ggaactccag atcctgagta atccttttag agcccgaaga gtcaaaaccc 1560

tcaatgttcc ctcctgctct cctgccccat gtcaacaaat ttcaggctaa ggatgaccca 1620

gacccagggc tctaaccttg tatgcgggca ggcccaggga gcaggcagca gtgttcttcc 1680

cctcagagtg acttggggag ggagaaatag gaggagacgt ccagctctgt cctctcttcc 1740

tcactcctcc cttcagtgtc ctgaggaaca ggactttctc cacattgttt tgtattgcaa 1800

cattttgcat taaaaggaaa atccactgct aaaaaaaaaa anaaaaaaaa agggcggccg 1860

cc 1862

75

gtgtctttaa gagggtggaa cggggcttcg cgtctgtgct tcctgtggct gacgtcatct 60

ggaggagatt tgctttcttt ttctccaaaa ggggaggaaa ttgaaactga gtggcccacg 120

atgggaagag gggaaagccc aggggtacag gaggcctctg ggtgaaggca gaggctaaca 180

tggggttcgg agcgaccttg ggccgttggc ctgaccatct ttgtgctgtc tgtcgtcact 240

atcatcatct gcttcacctg ctcctgctgc tgcctttaca agacgtgccg ccgaccacgt 300

ccggttgtca ccaccaccac atccaccact gtggtgcatg ccccttatcc tcagcctcca 360

agtgtgccgc ccagctaccc tggaccaagc taccagggct accacaccat gccgcctcag 420

ccagggatgc cagcagcacc ctacccaatg cagtacccac caccttaccc agcccagccc 480

atgggcccac cggcctacca cgagaccctg gctggaggag cagccgcgcc ctaccccgcc 540

agccagcctc cttacaaccc ggcctacatg gatgccccga aggcggccct ctgagcattc 600

cctggcctct ctggctgcca cttggttatg ttgtgtgtgt gcgtgagtgg tgtgcaggcg 660

cggttcctta cgccccatgt gtgctgtgtg tgtccaggca cggttcctta cgccccatgt 720

gtgctgtgtg tgtcctgcct gtatatgtgg cttcctctga tgctgacaag gtggggaaca 780

atccttgcca gagtgggctg ggaccagact ttgttctctt cctcacctga aattatgctt 840

cctaaaatct caagccaaac tcaaagaatg gggtggtggg gggcaccctg tgaggtggcc 900

cctgagaggt gggggcctct ccagggcaca tctggagttc ttctccagct taccctaggg 960

tgaccaagta gggcctgtca caccagggtg gcgcagcttt ctgtgtgatg cagatgtgtc 1020

ctggtttcgg cagcgtagcc agctgctgct tgaggccatg gctcgtcccc ggagttgggg 1080

gtacccgttg ccagagccag ggacatgatg caggcgaagc ttgggatctg gccaagttgg 1140

actttgatcc tttgggcaga tgtcccattg ctccctggag cctgtcatgc ctgttgggga 1200

tcaggcagcc tcctgatgcc agaacacctc aggcagagcc ctactcagct gtacctgtct 1260

gcctggactg tcccctgtcc ccgcatctcc cctgggacca gctggagggc cacatgcaca 1320

cacagcctag ctgcccccag ggagctctgc tgcccttgct ggccctgccc ttcccacagg 1380

tgagcagggc tcctgtccac cagcacactc agttctcttc cctgcagtgt tttcatttta 1440

ttttagccaa acattttgcc tgttttctgt ttcaaacatg atagttgata tgagactgaa 1500

acccctgggt tgtggaggga aattggctca gagatggaca acctggcaac tgtgagtccc 1560

tgcttcccga caccagcctc atggaatatg caacaactcc tgtaccccag tccacggtgt 1620

tctggcagca gggacacctg ggccaatggg ccatctggac caaaggtggg gtgtggggcc 1680

ctggatggca gctctggccc agacatgaat acctcgtgtt cctcctccct ctattactgt 1740

ttcaccagag ctgtcttagc tcaaatctgt tgtgtttctg agtctagggt ctgtacactt 1800

gtttataata aatgcaatcg tttggngctg ctgccccctt tcttcctggc ctcgg 1855

76

tttttttttg gaaagaacag tttgtgctgt gctttattaa aatgtgcatc attcttttat 60

tttaaaatgt gcatcattgt ctcgtgctcg gcgcatgcga cctcagcgtg gtggcccgct 120

gggggcctcg ttcccgccca gctcccgcgg agccgcaggg agcaggcgca ctcacgtggc 180

gcgggcccgg gggctcccgc ccatggcgag gtagacgtcg atgggcacgt gcagcagcgt 240

caggcagtgg catccagggc agcgacgaag cggcctgacc gggttgtgct ccgtcgctac 300

cgcctccggg ctgtcctggg actcgggggc ggcggcaagg ccacgggagt ctccggcctc 360

aatggggaat ctccgaccct gcgggggctc ctgggcgctc atgtccaagc cccggggcgc 420

tctcccggcg gttgagaccg gtcccaggct agaagcagct gccggagccc tggccgcggg 480

agaacgctcc ggtccag 497

77

gcggccgccg ggcggacgcg ctgctccgtc cacggccagc actggggcgg ccgggccccg 60

gtcccagaag ggaagcggga ggacggccac gcacacacgt cccgccgccg gtcatgctgc 120

tcagcctcgg gccgcgcgct taccaggcca ctcaaattca actactagag acatccctcc 180

aaccactggc ggtcctcgcg ctcgcccgga ggtgctgtta agggaaccag accacaaaga 240

ctgtgcgatt agcggcttct ggctggcgcc gtccacacgt gggcctccac agccctgtcc 300

taccactgcc ctggccaagc ctgctctgtg gacgtggcgt cccctctccc gggaagggcc 360

cctgacctgg cactcgagtg cccagtccgc ccaggctgcc gccgtggatg cggagcctgc 420

ctgggaaggt ggtgtgggca tgcagtcgct ggggaaccaa gaccaagcgt ttgaatacct 480

gcagcttgag gaatggcaaa ggtggg 506

78

gacgntgnct ttttttaatt tatttcaaaa atacttgttt attgcatggt tctctccaga 60

ttttatgtct aggcttactt ttatcataaa gtacttcagc aaagaagaga aactggcatt 120

caaacatggc cggccaatca ttgccaggct aattgcacaa gagcttctcc aagcaaatat 180

ttctcaccta ttacaaaccc cacattgata taggtgccac aaataataaa tgggataaaa 240

cagaagcccc tgtgcaaggg ggaagtcagt gaggaagagg gaaggaaaca agaggcaagg 300

agaccacgca catcactagt gtttctcttc atatggcaat ttaacattgc tgttctttgt 360

ctttatgaaa aatggggtta ggtcaggttc cttgtcatca caagtctcag aaatcatcta 420

gaaaacatat attttacaca ctagtctcac aactagacaa catattcagt acttcaagtg 480

gtagaatctt cagcttttca caccttaggc agttcttcca ccatctattt ctgtttcttc 540

attctcagtt cccaagaagg catagatcag gtcctagata ggttagcatt tcacatgtct 600

actccatttc atttgcaaca atgacaatga aaacccagca tgcaatgtgg ctgaggtgct 660

gggaacccca aacaatgtgg gggaaaaagc agagggcact tcacacccca gacgggacag 720

gtttccattc cttactgagg gtgg 744

79

gtgggatggg agcaggggca gagacgggca gagggcagag ggcggacggc gccggagcgg 60

gcgtcatggc gcggctcctc tggttgctcc ggggcctgac cctcggaact gcgcctcggc 120

gggcggtgcg gggccaagcg ggcggcggcg ggcccggcac cgggccggga ctgggggagg 180

cagggtctct tgcaacgtgt gagctgcctc ttgccaagag tgagtggcaa aagaaactaa 240

ccccggagca gttctacgtc acaagagaaa agggaacgga accgcctttc agtgggatct 300

acctgaataa caaggaagca ggaatgtatc attgcgtgtg ctgcgacagt ccactcttca 360

gttctgagaa aaagtactgc tctggcactg ggtggccttc gttttccgag gctcatggta 420

cgtctggctc tgatgaaagc cacacaggga tcctgagacg tctggatacc tcgttaggat 480

cagctcgcac agaggttgtc tgcaagcagt gtgaagctca tctaggtcac gtgtttcctg 540

atggacctgg gcccaatggt cagaggtttt gcatcaacag tgtggctttg aagttcaaac 600

caaggaaaca ctgaccatct tcaagagtcc cgttcccttg ccaccccttc acgtgcaccc 660

tcaatttcca caattcactt gaatgacttg ttttatttgc aataaaactg ggctgaattt 720

gctgctgtct ccagcgagtc attgcttctc ttaatttatt tacctggaat caacttaatc 780

ctgtgtgtta ggctgttctt gtgttgctat aaagaagtac ctgatcagga tctgggagat 840

ttgaaaaaaa agaaaaacta gaaaaataaa caaaattaaa agaaaaaaaa atacctga 898

80

gcggccgcgg ccaatcggag ccgctcttgc tgcgacgcag cggtcggaag cggacaaggt 60

cgaggccggg ttggcgccgg agccggggcc gcttggagct cgtgtggggt ctccggtcca 120

ggggcgcggc atgggcgtcc tgggccgcag cggcgcgctg cctggtccgg ggtgcggacc 180

gaatgagcaa gtggacgagc aagcggggcc cgcgcagctt caggggccgc aagggccggg 240

gcgccaaggg catcggcttc ctcacctcgg gctggaggtt cgtgcagatc aaggagatgg 300

tcccggagtt cgtcgtcccg gatctgaccg gcttcaagct caagccctac gtgagctacc 360

tcgcccctga gagcgaggag acgcccctga cggccgcgca gctcttcagc gaagccgtgg 420

cgcctgccat cgaaaaggac ttcaaggacg gtaccttcga ccctgacaac ctggaaaagt 480

acggcttcga gcccacacag gagggaaagc tcttccagct ctaccccagg aacttcctgc 540

gctagctggg cgggggaggg gcggcctgcc ctcatctcat ttctattaaa cgcctttgcc 600

agctaaaaaa aa 612

81

tcggcaggat gttaggnnnn nnnnnnnnnn nnnnnnnctc gtcggctgcg ctcctgaccg 60

gggagcggac cggctgctca cctgctacgt gcaggactac cttgagtgcg tggagtcgct 120

gccccacgac atgcagagga acgtgtctgt gctgcgagac tggacaacaa atatcaaggt 180

cggggctgtg ccgggggcgt tggttcggcc ccagcggagt ccgaatcggg gtttgcagca 240

tgttttgcgg tgatgtttcc aacctctttc ccagtcaatg gatcaggacg gcgatcagca 300

gctcggaccg tcgcggatcc tggctccgca aacgttaaag gaaattgatg atgtctacga 360

aaaatataag aaagaagatg atttaaacca gaagaaacgt ctacagcagc ttctccagag 420

agcactaatt aatagtcaag aattgggaga tgaaaaaata cagattgtta cacaaatgct 480

cgaattggtg gaaaatcggg caagacaaat ggagttacac tcacagtgtt tccaagatcc 540

tgctgaaagt gaacgagcct cagataaagc aaagatggat tccagccaac cagaaagatc 600

ttcaagaaga ccccgcaggc agcggaccag tgaaagccgt gatttatgtc acatggcaaa 660

tgggattgaa gactgtgatg atcagccacc taaagaaaag aaatccaagt cagcaaagaa 720

aaagaaacgc tccaaggcca agcaggaaag ggaagcttca cctgttgagt ttgcaataga 780

tcctaatgaa cctacatact gcttatgcaa ccaagtgtct tatggggaga tgataggatg 840

tgacaatgaa cagtgtccaa ttgaatggtt tcacttttca tgtgtttcac ttacctataa 900

accaaagggg aaatggtatt gcccaaagtg caggggagat aatgagaaaa caatggacaa 960

aagtactgaa aagacaaaaa aggatagaag atcgaggtag taaaggccat ccacatttta 1020

aagggttatt tgtcttttat ataattcgtt tgctttcaga aaatgtttta gggtaaatgc 1080

ataagactat gcaataattt ttaatcatta gtattaatgg tgtattaaaa gttgttgtac 1140

tttgaaaaaa aaaa 1154

82

ggtcgtgcca gatccgccgg acgccggaag tggttctccg cccctgccac tgggccatgg 60

agactgtggg cacagtagac tgtagtgtga ggctcgcggg gggcagtggc catggaggcc 120

cgtgctgaac gagctggtgt ctgtggagga cctgctgaag tttgaaaaga aatttcagtc 180

tgagaaggca gcaggctcgg tgtccaagag cacgcagttt gagtacgcct ggtgcctggt 240

gcggagcaag tacaatgatg acatccgtaa aggcatcgtg ctgctcgagg agctgctgcc 300

caaagggagc aaggaggaac agcgggatta cgtcttctac ctggccgtgg ggaactaccg 360

gctcaaggaa tacgagaagg ccttaaagta cgtccgcggg ttgctgcaga cagagcccca 420

gaacaaccag gccaaggaac tggagcggct cattgacaag gccatgaaga aagatggact 480

cgtgggcatg gccatcgtgg gaggcatggc cctgggtgtg gcgggactgg ccggactcat 540

cggacttgct gtgtccaagt ccaaatcctg aaggagacgc gggagcccac ggagaacgct 600

ccaggagggc ctgtccatcc tcgctgtcct ttccctgttc tccccctgtt ctccccctgc 660

cccccgtctc tatcctctgt ggccttcagc taatttctgc tcccctgaga ttcgtccttc 720

agccccatca tgtgctttgg gatgagtgta aataaaacgg ggctgtggct tgggaa 776

83

acagaagtag ctctggctgt gatggggatc ttactgggcc tgctactcct ggggcaccta 60

acagtggaca cttatggccg tcccatcctg gaagtgccag agagtgtaac aggaccttgg 120

aaaggggatg tgaatcttcc ctgcacctat gaccccctgc aaggctacac ccaagtcttg 180

gtgaagtggc tggtacaacg tggctcagac cctgtcacca tctttctacg tgactcttct 240

ggagaccata tccagcaggc aaagtaccag ggccgcctgc atgtgagcca caaggttcca 300

ggagatgtat ccctccaatt gagcaccctg gagatggatg accggagcca ctacacgtgt 360

gaagtcacct ggcagactcc tgatggcaac caagtcgtga gagataagat tactgagctc 420

cgtgtccaga aactctctgt ctccaagccc acagtgacaa ctggcagcgg ttatggcttc 480

acggtgcccc agggaatgag gattagcctt caatgccagg ctcggggttc tcctcccatc 540

agttatattt ggtataagca acagactaat aaccaggaac ccatcaaagt agcaacccta 600

agtaccttac tcttcaagcc tgcggtgata gccgactcag gctcctattt ctgcactgcc 660

aagggccagg ttggctctga gcagcacagc gacattgtga agtttgtggt caaagactcc 720

tcaaagctac tcaagaccaa gactgaggca cctacaacca tgacataccc cttgaaagca 780

acatctacag tgaagcagtc ctgggactgg accactgaca tggatggcta ccttggagag 840

accagtgctg ggccaggaaa gagcctgcct gtctttgcca tcatcctcat catctccttg 900

tgctgtatgg tggtttttac catggcctat atcatgctct gtcggaagac atcccaacaa 960

gagcatgtct acgaagcagc cagggcacat gccagagagg ccaacgactc tggagaaacc 1020

atgagggtgg ccatcttcgc aagtggctgc tccagtgatg agccaacttc ccagaatctg 1080

ggcaacaact actctgatga gccctgcata ggacaggagt accagatcat cgcccagatc 1140

aatggcaact acgcccgcct gctggacaca gttcctctgg attatgagtt tctggccact 1200

gagggcaaaa gtgtctgtta aaaatgcccc attaggccag gatctgctga cataattgcc 1260

tagtcagtcc ttgccttctg catggccttc ttccctgcta cctctcttcc tggatagccc 1320

aaagtgtccg cctaccaaca ctggagccgc tgggagtcac tggctttgcc ctggaatttg 1380

ccagatgcat ctcaagtaag ccagctgctg gatttggctc tgggcccttc tagtatctct 1440

gccgggggct tctggtactc ctctctaaat accagaggga agatgcccat agcactagga 1500

cttggtcatc atgcctacag acactattca actttggcat cttgccacca gaagacccga 1560

gggaggctca gctctgccag ctcagaggac cagctatatt caggatcatt tctctttctt 1620

cagggccaga cagcttttaa ttgaaattgt tatttcacag gccagggttc agttctgctc 1680

ctccactata agtctaatgt tctgactctc tcctggtgct caataaatat ctaatcataa 1740

cagc 1744

84

ctggagccgc cctgggtgtc agcggctcgg ctcccgcgca cgctccggcc gtcgcgcacc 60

tcgggcacct gcaggtccgt ggcgtcccgc ggctgggcgc ccctgactcc gtcccggcca 120

gggagggcca tgatttccct cccggggccc ctggtgacca acttgctgcg gtttttgttc 180

ctggggctga gtgccctcgc gcccccctcg cgggcccagc tgcaactgca cttgcccgcc 240

aaccggttgc aggcggtgga gggaggggaa gtggtgcttc cagcgtggta caccttgcac 300

ggggaggtgt cttcatccca gccatgggag gtgccctttg tgatgtggtt cttcaaacag 360

aaagaaaagg aggatcaggt gttgtcctac atcaatgggg tcacaacaag caaacctgga 420

gtatccttgg tctactccat gccctcccgg aacctgtccc tgcggctgga gggtctccag 480

gagaaagact ctggccccta cagctgctcc gtgaatgtgc aagacaaaca aggcaaatct 540

aggggccaca gcatcaaaac cttagaactc aatgtactgg ttcctccagc tcctccatcc 600

tgccgtctcc agggtgtgcc ccatgtgggg gcaaacgtga ccctgagctg ccagtctcca 660

aggagtaagc ccgctgtcca ataccagtgg gatcggcagc ttccatcctt ccagactttc 720

tttgcaccag cattagatgt catccgtggg tctttaagcc tcaccaacct ttcgtcttcc 780

atggctggag tctatgtctg caaggcccac aatgaggtgg gcactgccca atgtaatgtg 840

acgctggaag tgagcacagg tcagtgaggg ggcctggagc tgcagtggtt gctggagctg 900

ttgtgggtac cctggttgga ctggggttgc tggctgggct ggtcctcttg taccaccgcc 960

ggggcaaggc cctggaggag ccagccaatg atatcaagga ggatgccatt gctccccgga 1020

ccctgccctg gcccaagagc tcagacacaa tctccaagaa tgggaccctt tcctctgtca 1080

cctccgcacg agccctccgg ccaccccatg gccctcccag gcctggtgca ttgaccccca 1140

cgcccagtct ctccagccag gccctgccct caccaagact gcccacgaca gatggggccc 1200

accctcaacc aatatccccc atccctggtg gggtttcttc ctctggcttg agccgcatgg 1260

gtgctgtgcc tgtgatggtg cctgcccaga gtcaagctgg ctctctggta tgatgacccc 1320

accactcatt ggctaaagga tttggggtct ctccttccta taagggtcac ctctagcaca 1380

gaggcctgag tcatgggaaa gagtcacact cctgaccctt agtactctgc ccccacctct 1440

ctttactgtg ggaaaaccat ctcagtaaga cctaagtgtc caggagacag aaggagaaga 1500

ggaagtggat ctggaattgg gaggagcctc cacccacccc tgactcctcc ttatgaagcc 1560

agctgctgaa attagctact caccaagagt gaggggcaga gacttccagt cactgagtct 1620

cccaggcccc cttgatctgt accccacccc tatctaacac cacccttggc tcccactcca 1680

gctccctgta ttgatataac ctgtcaggct ggcttggtta ggttttactg gggcagagga 1740

tagggaatct cttattaaaa ctaacatgaa atatgtgttg ttttcatttg caaatttaaa 1800

taaagataca taatgtttgt atgagataag a 1831

85

ctttcatcta ccaatccatg tgcattggat tgcacactaa gatgtatttt cttacgaaat 60

agttctgtgt ttatttttta attatagaaa ttccaaagaa cagcacatca gaatgctcct 120

ctcttttcag taattgtttt agttcagaga tcttcccgct cagcctccat aaatctaatg 180

tcattttttt tttaataagt cctaggagct ggggcttcat tcctccagcg ggagtccagt 240

cagggtcctg aagtttgctg gttcaggaaa gaacaggaaa gagaaaagcc ttctgtgccc 300

aggctaaagc tgttacattt ccacagtgtg gatgcagtca gaatccctgc acattctggt 360

cataaggatt agagtcacca gatgaggctc taaacagatc gcatcccttg gaattagaaa 420

gcagtggaga ccgggcgcag tgactcacac ctg 453

86

ttttttcaca tttctttaca tttaatgtaa ataccaacag tggtcaccta tcaacatcat 60

ggaagagcac acttcacagg tttcataatc aaattttaaa ataatcacat gtaataaaaa 120

caaatgacta aaatacaaaa atgtaatgta tttatttact aaatggttag ctataaagat 180

acaatttctg ccttggagtt taaagcagtt tcattttttg ccatagttac tttttctgat 240

aatatgctag aatcacagtc ttctctgttt tatctggatt gtagggattg tttacatttt 300

atatgtttgt tcacttgaga accaaatttt tttttcttca tgatgatgga agctctgtaa 360

tataaaaatg tcattgtgct catatatttg aataataccg atcacggttt tcaaagtctc 420

tatgagcata tcttgcataa gtcttgttat gtgggatcct tccaaaaggt tcatggtcat 480

tgaaacaaga ttcaaaaact tcatcaacag cctttttagc tacttctttg ctgatattcc 540

taacagccag gatagaaaga gtggctctgt ctcgcacaca agtctggtgg tgttgtttta 600

atccaaaatg taacctgaat atttcattga caagtgagca gtctccacta aggttagcag 660

ctcgaacctc tgagcacgcc aaatgtctga tgttggtgaa ccagtcgaca tgggcacgac 720

aatgatcaaa tgcatgaata agctcgtgtg tgaccactct gttcatatgg gcctgattat 780

ggatattatt ctggcacaaa actatctgag atgttgaagc atcaaaacct ccactgacat 840

ttccattaca gtcttcgcaa gaaaagtgtc tatctttgtt aacagcacaa cctgagtgtt 900

tcatagcatc aagcagaagt ttgacatatg gatttgtctc cagcgtcttc aggagcctaa 960

gctggcactt ctggttgctg gtgaagaagc tggagaagaa cccttgctgg ggattcccct 1020

gggccagacg ctcggggaag acctggcaag agacgtgttg ctgctgcagc tgctcccctg 1080

ccgcggggcc ccgccggcgc tcgtccggag ctcccgccat gcctcccgca gacctcgccg 1140

ctgcttcctc ctggctcagg cggccagagc gagactggga aaggtaacct ccctcccgcc 1200

aacgcgaccg cccaggccct ccctcngcag ggaagaaggg cagcctggct gggctgaaga 1260

cgttaggc 1268

87

gggcgaagag gggcgcaagt tcattgcgtt ttgagtctcg ggacccctgt tggagagact 60

atggcgctca acaagaatca ctcggagggc ggcggagtga tcgtcaataa caccgagagc 120

atcctaatgt cctatgatca cgtggaactc acattcaatg acatgaagaa cgtgccagaa 180

gccttcaaag ggaccaagaa aggcactgtc taccttaccc cttaccgggt catctttctg 240

tccaagggca aggatgccat gcagtccttc atgatgccat tttatctcat gaaagactgt 300

gagatcaagc agcccgtatt tggtgcaaac tacatcaagg gaacagtgaa ggcggaagcg 360

ggaggtggct gggaaggctc tgcttcctac aagttgactt tcacggcagg gggcgccatt 420

gagttcggac agcggatgct ccaggtggca tctcaagcct ccagaggtga agtccccagt 480

ggagcctatg gctactctta catgcccagc ggggcctatg tctatccccc gccagtcgcc 540

aatggaatgt acccctgccc tcctggctac ccctatccac cgcccccacc tgagttctat 600

ccaggacccc ccatgatgga cggggccatg ggatacgtgc agcccccacc accgccctac 660

cctgggccca tggaacctcc ggttcagcgg ccccgatgtc ccctccactc ctgcagccga 720

agccaaggcc gcagaagcag ccgccagcgc ctattacaac ccaggcaatc ctcacaacgt 780

ctacatgccc acgagccagc cgccgccacc tccctactac ccaccggaag ataagaagac 840

ccagtaggcc ctcctgcctc cctgcctccc accctcatct ctctacccta cccctcccat 900

cggggctgtg ctggggcttg gggaggggag ggggcgcctt gttctccctc caggtctgat 960

cataaacaat taccaggaac tagcattgtg ggacattagg gcccccggcc tcgggagagg 1020

tgccgcccag cttcccatgc cagcccggag cccacagtgc tgcccagcgt acctccctca 1080

ccgtctgggg ctcttctggg agcacggagc atcccctgtt cctgtttcac tctcagcttc 1140

tcccctcgaa gggactctct ggccacctcc tccaccgcag tccagctccc tcagtctggg 1200

cacccactgc tacactcagc ctcatgagcc acttcagacc agccaggtgt cttcccgggc 1260

cctgccagac cctgctcaca ttccctctgc tggtctgtgc tggtctcaga aggccaccgc 1320

gcccgcattc cactcagcca gggtccagct gcagcccccg ccacccttcc ttcccttccc 1380

tgtcctgggt catgttgttg ccaccctgtg tgacttttga agctgtaaaa tgagcttcca 1440

gggcttgggt ggcgtcgggg cagggccgcc gaggctggga ggaagccctt ctgccttttg 1500

ctggtgtttc tggaatttgc tttccctcac ctctcacttc cttctagaag gagcttcctg 1560

actggaacca gagaatgcat gtctgtccac ttggtggctg ctgggtgggg ccgggaacaa 1620

gggcccctga ccctgtgtgc tggccgggac ctgccaccag ccccccagcc tgcttcttcc 1680

ccttaagctt tgtgcccctg gatgcgctaa cattcactct tgtttgtccc tggactggcc 1740

atgaagtgag gagatggtta tttaaagaga attccctatt tatttgacaa aaaatccagt 1800

taatatatta atgtgaaata aaccctgttt gcacctcgat ttgtttgctg aaaatgtgaa 1860

atagtaaaaa tgaaataact ggaaa 1885

88

cacccttgcc acctgtcatt cccacttgga ccaggccagc agcctccctg gtctctctga 60

ccctccccct gagttcgttc accaaaggca gtaacggaga caccccctca acacacacag 120

gaagcagatg gccttgacac cagcagggtg acatccgcta ttgctacttc tctgctcccc 180

cacagttcct ctggacttct ctggaccaca gtcctctgcc agacccctgc cagaccccag 240

tccaccatga tccatctggg tcacatcctc ttcctgcttt tgctcccagt ggctgcagct 300

cagacgactc caggagagag atcatcactc cctgcctttt accctggcac ttcaggctct 360

tgttccggat gtgggtccct ctctctgccg ctcctggcag gcctcgtggc tgctgatgcg 420

gtggcatcgc tgctcatcgt gggggcggtg ttcctgtgcg cacgcccacg ccgcagcccc 480

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggctgacc ctcctgcagc 540

ttggaccttt gacttctgac cctctcatcc tggatggtgt gtggtggcac aggaaccccc 600

gccccaactt ttggattgta ataaaacaat tgaaacacca aaaaaaaaaa agtgcanaga 660

catgagaaga caccagcgca aggcccacac aaaaggggcg gccgccgact aagtagccct 720

tcgcccgggg acttaattcc ggacgggtgc ctt 753

89

ggagcgcagg tgaggcggcg ccccactccc ggcngccccc gggcctcctt ccgcncgcac 60

cccgagctgc ctccgcacag ttggaggagc gtaggaggga cccccaccca gggatgacac 120

tccaggaagg ggactgcaga ggaagccagc cgttcctctc tggtgctccc ttcctcatag 180

actgtgtccc tgacaatggg aacagcccga ccagtgatga gatggccccg gaggccccac 240

agcacaccca cattcgatgt gcacatccac caggagtctg ccctggccaa gctcctgctc 300

acctgctgct ctgcgctgcg gccccgggcc acccaggcca gggggcagca gccggctgct 360

ggtggcctca tgggtgatgc agatcgtgct ggggatcttg agtgcagtcc taggaggatt 420

tttctacatc cgcgactaca ccctcctcgt cacctcggga gctgccatct ggacaggggc 480

tgtggctgtg ctgggctgga gctgctgcct tcatttacga gaaacggggt ggtacatact 540

gggccctgct gaggactctg ctagcgctgg cagctttctc cacagccatc gctgccctca 600

aactttggaa tgaagatttc cgatatggct actcttatta caacagtgcc tgccgcatct 660

ccagctcgag tgactggaac actccagccc ccactcagag tccagaagaa gtcagaaggc 720

tacacctatg tacctccttc atggacatgc tgaaggcctt gttcagaacc cttcaggcca 780

tgctcttggg tgtctggatt ctgctgcttc tggcatctct ggcccctctg tggctgtact 840

gctggagaat gttcccaacc aaaggggtga gtccctaaga aaagagacca gaaggaaatg 900

ttggaagtga gtggaatcta gccatgcctc tcctgattat tagtgcctgg tgcttctgca 960

ccgggcgtcc ctgcatctga ctgctggaag aagaaccaga ctgaggaaaa gaggctcttc 1020

aacagcccca gttatcctgg ccccatgacc gtggccacag ccctgctcca gcagcacttg 1080

cccattcctt acaccccttc cccatcctgc tccgcttcat gtcccctcct gagtagtcat 1140

gtgataataa actctcatgt tattgaaa 1168

90

ctccactccc caccagaaac tcttattttt tcccccctat gtggtcatga attcctcctg 60

ggtgcatagc tccctaagtt gttctgtgtt ttagtgctta taatttccca catcccatga 120

tgcccnttna tagaattatt ttttctgtac tcacacgaaa tggaaacaga agagatgaaa 180

aaccctgggg atgcggccnc tcangtctca aactgatcgg ctgctaagca caacctgcat 240

atctcttggc tgagttcctt tcttggctca gttagatttt gcatgaccta ggaggcttag 300

gacccagggg gcgcctttca gctgaaaaac agtctcgcgc tgcagcaagc tagctgggaa 360

gctcccagtt ctaaagagag gctgtttacc agaacagcat aacaagggca ggtctgactg 420

caaggctggg actgggaggc agagccgccg ccaagggggc ctcggttaaa cactggtcgt 480

tcaatcacct gcaagacgaa ggaggcaagg atgctgttgg cctgggtaca agcattcctc 540

gtcagcaaca tgctcctagc agaagcctat ggatctggag gctgtttctg ggacaacggc 600

cacctgtacc gggaggacca gacctccccc gcgccgggcc tccgctgcct caactggctg 660

gacgcgcaga gcgggctggc ctcggccccc gtgtcggggg ccggcaatca cagttactgc 720

cgaaacccgg acgaggaccc gcgcgggccc tggtgctacg tcagtggcga ggccggcgtc 780

cctgagaaac ggccttgcga ggacctgcgc tgtccagaga ccacctccca ggccctgcca 840

gccttcacga cagaaatcca gtaagcgtct gaagggccag gtgcagatga ggtgcaggtg 900

ttcggctcct gccaacgccc tgcccgctcg gagtgaggcg gcagctgtgc agccagtgat 960

tgggatcagc cagcgggtgc ggatgaactc caaggagaaa aaggacctgg gaactctggg 1020

ctacgtgctg ggcattacca tgatggtgat catcattgcc atcggagctg gcatcatctt 1080

gggctactcc tacaagaggg ggaaggattt gaaagaacag catgatcaga aagtatgtga 1140

gagggagatg cagcgaatca ctctgccctt gtctgccttc accaacccca cctgtgagat 1200

tgtggatgag aagactgtcg tggtccacac cagccagact ccagttgacc ctcaggaggg 1260

cagcaccccc cttatgggcc aggccgggac tcctggggcc tgagcccccc cagtgggcag 1320

gagcccatgc agacactggt gcaggacagc ccaccctcct acagctagga ggaactacca 1380

ctttgtgttc tggttaaaac cctaccactc ccccgctttt ttggcgaatc ctagtaagag 1440

tgacagaagc aggtggccct gtgggctgag ggtaaggctg ggtagggtcc taacagtgct 1500

ccttgtccat cccttggagc agattttgtc tgtggattga gacagtggca gctcccacag 1560

tgatgctgct gctaagggct tccaaacatt gcctgcaccc ctggaactga accagggata 1620

gacggggagc tcccccaggc tcctctgtgc tttactaaga tggcctcagt ctccactgtg 1680

ggcttgagtg gcatacactg ttattcatgg ttaaggtaaa gcaggtcaag ggatggcatt 1740

gaaaaaatat atttagtttt taaaatattt gggatggaac tccctactga cctctgagaa 1800

ctggaaacga gtttgtacag aagtcagaac tttgggttgg gaatgagatc taggttgtgg 1860

ctgctggtat gcttcagctt gctggcaatg atgtgccttg acaaccgtgg gccaggcctg 1920

ggcccagggg actcttcctg tttcataagg aaaggaagaa ttgcactgag cattccactt 1980

aggaagagga tagagaagga tctgctccgc ctttggccac aggagcagag gcagacctgg 2040

ggatgcccca gtttctcttc agggatggat agtgacctgt cttcattttg cacaggtaag 2100

agagtagtta gctaacctat gggaattata ctgtggggcc ttgtgagctg cttctaagag 2160

gctaacctgg aaactaagct cagagggcaa ggtaataaag cacttcaggg cttgctcccc 2220

aagtgggcct gatttagcag gtggtcctgc gggcgtccag gtcagcacct tcctgtaggg 2280

cactggggct agggtcacag cccctaactc ataaagcaat caaagaacca ttagaaaggg 2340

ctcattaagc cttttggaca caggacccca gagaggaaaa agtgacttgc ccaaggtcgt 2400

aagcaagcta ctggcatggc aagagcccag cttcctgacg gagcgcaaca tttctccact 2460

gcactgtgct agcagctcag cagggcctct aacctgtgat gtcacactca agaggccttg 2520

gcagctccta gccatagagc ttcctttcca gaacccttcc actgcccaat gtggagacag 2580

gggttagtgg ggctttctat ggagccatct gctttgggga cctagacctc aggtggtctc 2640

ttggtgttag tgatgctgga gaagagaata ttactggttt ctacttttct ataaaggcat 2700

ttctctatat acatgtttta tatacctcat tctgacacct gcatatagtg tgggaaattg 2760

ctctgcattt gacttaatta aaaaaaaaaa aaaagggc 2798

91

agggagagaa aaaaattgta aaaataaaaa tagtaaaaga aactgataaa gaaaagtaat 60

ggaagacagg aagaaaagaa gagaaggaag taaagaggaa aacttataaa tattcccaca 120

gatagacaaa gtcaagcata aaactggagc ttgagaagga aatgaaaggc cgtggcacct 180

tcttataccc tagaagaaga cctccataca ggaagacttg tgtgtggggt tgggacatta 240

gaatcatcca caagtcaccc caaaccttgg aactgtcagg gtcagagggg aaccaccatt 300

tattaagcat ttgccatgtg ccaggcacta acccagatgc attataaata ccacgttgtt 360

tcacctgtgt gtggcatcta cagaccttag atcatagctg tgagaacaac gtaagcactg 420

ccaaagttat cagctaccca tatctcatgt ttttgatgtt atctactctt cctagaatca 480

aatattaaaa taattttaaa acc 503

92

ggtgaggnaa aaaaaaatta aaaaaaaaat gcaagctgtc aggatgctta agctcttttc 60

agacatctgc agtttcatcc ctaccttgtt cacataccat ccaagaggca cataggctac 120

ccaagagagc cttggattca gtggtacact ccttgggccc aagggcttta gcagctggat 180

atggggttcc ttgattttcc tctgggccca aatatagccc tcacactctt ggaatttcca 240

ggtatggggg tagccccaaa aggaggaatc tcctatggcc aataaggtat cttgacttta 300

tcaaagtaga agagagggtc acttcggagt caaatcatac actaggcctt tgatgcttta 360

attcttcttc agttcattaa aagtaactac taaggaaagg ttaaaaactt cccctcaaaa 420

aggaatcaac cccaggaagt aattatttac aacgattttc ccaaattttg tacaatctgt 480

cctggaaagc aaaccccttt taaaatctaa tgtctgggct ttgagtatta gctcatttag 540

ggtggacaaa tgcattactg ttttcaaact gctcacattt attcagtatt tctccaagtt 600

gctatctact cagccttatg aatgcccctc gcttttctaa ggccatgtga aaatcacggc 660

actgccctta gccttgtgtc atctgctttt tcgttctgcg atatgcccag ttcccaaatc 720

aattataggt acctgtttag gagagaggaa gattttacct ctcaaagggt gagatttgaa 780

atttacacta aaaagacaac tttacattta atgcttcact taatgagaca ttcttttttt 840

tataagtcta tttttctact cagtttcaga acactaatct gattttcact ctgattttta 900

acgtttcttt aaatatttat aatgtagctt ctttcaaaat attttcatga aaaattactt 960

ttattatacc attatgtgca tgttattggt agcaggcata gtttattatt tagtactgaa 1020

acatgctctt ttacctaaca gtaaaaccaa gtatgttttg ataatatatc tgttaatatg 1080

cttatagtgg taagaaatgg acttgaggtc ccaggagatt tcattttatt caccctggtc 1140

agatacaata aaggctatga gtataaatac ataacttcct aaccaggtgt agggcatgtt 1200

catgaatatc aaatcttttg atgctggacc caagagagga aaagttgtag ctaaatgttg 1260

atttacttat aactagacgt ctatgtgaga aaatatatgt atacatatat atgatatgca 1320

gaagtcactt tttttatcag gctttattct ccttacaaag ccacagttta actgtctgca 1380

acagttggtt tatgttaatg atagacaaat acccagtgtt tgttactttt tccaactacc 1440

actgtaatga taatctttct cacgtatata catgcaactt cttggcttca tttccatgaa 1500

gctgtttcaa tatattcagt atactttgtc cttaatgctg cttctgttaa cagtgatctc 1560

tttctttttt tcattcttat atcttcatta gttcatcata aatctgtcca gttgaggcct 1620

caggaccacg gcatgatttc atgactccga agtattttac agaaacattt tttaaataag 1680

ggaaatattt tatataccag atggttcaca agtgatggct catagctagt tttttttttc 1740

ttctaaaaaa tgtcaggttt ttaaaatcat ttaccttatt aaaatgaaaa gtgccatact 1800

taacttttaa aggaaagacc tgacttgctt tttctctatt tagactgttt ttgtacttta 1860

ctaatcttta aactatcagg aaaaaaacca aaactttata ccaatgattt agtaattttg 1920

aggcataggg tagcttacgt agtgggagga tgtgccaaat attctcttca aatgccacct 1980

tctcaattta taactaaaat agtgttatct gactaattcc tctgaatttt gatgtaagat 2040

ctatataggc ccccaaaatg atcgtagtac atgccagtca tttctcagtg aaataaatac 2100

aataccagag tacattatga gttttattgc tttcttttat ggtagacctg ttaatgggga 2160

aaaaatacat caaatcaaat agaatcttat atctgtatgt taaaatagag cacttacctg 2220

aagtcagtgg cctgggatca tagccctgga tcatttccca gtctgtcctg tgctgtgtga 2280

ccttggacaa ggcgcttcat ctctctgggc ctctatttct ccatttgtaa aacaagtggc 2340

tgcagtagat gatggctgag agcccttcct gttcccagat gccttggtcc aaagacccca 2400

cccctctgct ggtcctgcca acgtgttggt gctataagct gcttcagata taaaattggt 2460

ttatctataa tgtttgttca tttaatagct tctaaaaggc ctttttgtta tacagtgctt 2520

tttttctagt tttatggact tggttactgt aataatgtct tgtttttagc catgtaacta 2580

caaacagata ttctcttgat gtcttagtaa atttgcattt gatatatcat tgatgagatt 2640

ttgttgttat gtaatattct ttggctacgc atctgtccag catcttatta accataatac 2700

tgtgatcatt atttggaaat atgtcctatg gaaagaataa aagcatgtac ttcacagcta 2760

gcatgttcac agatttgaaa gaagtttcat taaaagcacc attgctttct gtactgcgtc 2820

agtgcctcat tgtatcatcc tacttgtgtt ttgctcaata aatgaataaa agaccatttc 2880

tcttc 2885

93

gtttcaaagg acacaaagag agatgtggac tcaaagtcac cggggatgcc tttatttgaa 60

gcagaggaag gagttctatc acgaacccag atatttccta ccactattaa agtcattgat 120

ccagaatttc tggaggagcc acctgcactt gcatttttat ataaggatct gtatgaagaa 180

gcagttggag agaaaaagaa ggaagaggag acagcttctg aaggtgacag tgtgaattct 240

gaggcatcat ttcccagcag aaattctgac actgatgatg gaacaggaat atattttgag 300

aagtacatac tcaaagatga cattctccat gacacatctc taactcaaaa ggaccagggc 360

caaggtctgg aagaaaaacg agttggtaag gatgattcat accaaccgat agctgcagaa 420

ggggaaattt ggggaaagtt tggaactatt tgcagggaga agagtctgga agaacagaaa 480

ggtgtttatg gggaaggaga atcagtagac catgtggaga ccgttggtaa cgtagcgatg 540

cagaagaaag ctcccatcac agaggacgtc agagtggcta cccagaaaat aagttatgcg 600

gttccatttg aagacaccca tcatgttctg gagcgtgcag atgaagcagg cagtcacggt 660

aatgaagtcg gaaatgcaag tccagaggtc aatctgaatg tcccagtaca agtgtccttc 720

ccggaggaag aatttgcatc tggtgcaact catgttcaag aaacatcact agaagaacct 780

aaaatcctgg tcccacctga gccaagtgaa gagaggctcc gtaatagccc tgttcaggat 840

gagtatgaat ttacagaatc cctgcataat gaagtggttc ctcaagacat attatcagaa 900

gaactgtctt cagaatccac acctgaagat gtcttatctc aaggaaagga atcctttgag 960

cacatcagtg aaaatgaatt tgcgagtgag gcagaacaaa gtacacctgc tgaacaaaaa 1020

gagttgggca gcgagaggaa agaagaagac caattatcat ctgaggtagt aactgaaaag 1080

gcacaaaaag agctgaaaaa gtcccagatt gacacatact gttacacctg caaatgtcca 1140

atttctgcca ctgacaaggt gtttgggcac ccacaaagac catgaagttt caacgcttga 1200

cacaagctat aagtgctgta aaggttcaat tagcagaatt tctagaaaat ttacaagaaa 1260

agtccttgag gattgaagcc tttgttagtg agatagaatc cttttttaat accattgagg 1320

aaaactgtag taaaaatgag aaaaggctag aagaacagaa tgaggaaatg atgaagaagg 1380

ttttagcaca gtatgatgag aaagcccaga gctttgagga agtgaagaag angangatgg 1440

agttcctgca tgagcagatg gtccactttc tgcagagcat ggacactgcc aaagacaccc 1500

tggagaccat cgtgagagaa gcagaggagc ttgatgaggc cgtcttcctg acttcgtttg 1560

aggaaatcaa tgaaaggttg ctttctgcaa tggagagcac tgcttcttta gagaaaatgc 1620

ctgctgcgtt ttcccttttt gaacattatg atgacagctc ggcaagaagt gaccagatgt 1680

taaaacaagt ggctgttcca cagcctccta gattagaacc tcaggaacca aattctgcca 1740

ccagcacaac aattgcagtt tactggagca tgaacaagga agatgtcatt gattcatttc 1800

aggtttactg catggaggag ccacaagatg atcaagaagt aaatgagttg gtagaagaat 1860

acagactgac agtgaaagaa agctactgca tttttgaaga tctggaacct gaccgatgct 1920

atcaagtgtg ggtgatggct gtgaacttca ctggatgtag cctgcccagt gaaagggcca 1980

tctttaggac agcaccctcc acccctgtga tccgcgctga ggactgtact gtgtgttgga 2040

acacagccac tatccgatgg cggcccacca ccccagaggc cacggagacc tacactctgg 2100

agtactgcag acagcactct cctgagggag agggcctcag atctttctct ggaatcaaag 2160

gactccagct gaaagttaac ctccaaccca atgataacta ctttttctat gtgagggcca 2220

tcaatgcatt tgggacaagt gaacagagtg aagctgctct catctccacc agaggaacca 2280

gatttctctt gttgagagaa acagctcatc ctgctctaca catttcctca agtgggacag 2340

tgatcagctt tggtgagagg agacggctga cggaaatccc gtcagtgctg ggtgaggagc 2400

tgccttcctg tggccagcat tactgggaaa ccacagtcac agactgcccc agcatattcg 2460

actcggcatc tgctccagct tcggctgtgc aggcaggtgc cctaggacaa ggggagacct 2520

catggtacat gcactgctct gagccacaga gatacacatt tttctacagt ggtattgtga 2580

gtgatgttca tgtgactgag cgtccagcca gagtgggcat cctgctggac tacaacaacc 2640

agagacttat cttcatcaac gcagagagcg agcagttgct cttcatcatc aggcacaggt 2700

ttaatgaggg tgtccaccct gcctttgccc tggagaaacc tggaaaatgt actttgcacc 2760

tggggataga gcccccggat tctgtaaggc acaagtgatc cttggctttc agaatttgca 2820

agaacagcga tttgaatttt gggggggtct gctgttcatt cctttaggtg ctatacatta 2880

ttcaaaaagt ctcccgcgca tttgcactaa tgatggctgc atgcatagca atcagcatgt 2940

gagcaaaatc gacaagaaaa ccttgacttt acagagcagt gtgtgagtaa acagaatgaa 3000

aacaacaacc tccactcttt agtttatata agtttgagtt ctttcctaaa ttaaaagatc 3060

tacacttgag ttgggaaccg aaagagaaaa atggacttcc atctgtttta ctggtaaagg 3120

aaatcctctg atggacaggt cagagtgaag gaaggttgtg ctggtaagac atctctgacg 3180

aagagccatg gatgctttcc acaaaatgtc acctcgctgc actaaaggat gatgaatcct 3240

aatcattaaa ggaattgttt cagctgattt aaatttataa tgaactcttt tgtaataatg 3300

tatactgtag aacatgagtc tctcctccct aaaattttaa atgtagaaaa gtgctatata 3360

ttagaaattt ccattttgtt aaataaatgg ttagagtcta taaagccagt catgttatgt 3420

gaacttactc catgtaactt actggc 3446

94

tgatttcatt cattcattta ttcaattttt tttaaaaaag ctattacgtt aaactcttag 60

gatgaggaca agccttacaa tggtgtgtga gtgtgagtat gtgttcatgc atacactcac 120

atccctgtgt ctgagtgttg tgggtgtgtg tgatgtctgt gcatttctat gtggtatgta 180

ttcatatgca tgtgtattgg ggtacactaa atttgggttt gcacagaaaa gaataaacag 240

aattgtactg gaatagttta cctagtgctt cctctaagaa cagcacacag ctcattcagt 300

tttgctgatt ttcatcctct gcatccacaa agcacactga ggtctctcct atcaccttga 360

caatggggat ttgaccccaa ccatctccac cgcagttgga ctgacaggca gcaagtggtg 420

ctcatcaaag acagctctga ggaggctttc gggagaca 458

95

ggcctatgga gcagccctga tctgcaagga gcggcatctc tggcgctgct gtgcacagct 60

gcttccatga aagctgctgc ctaacaccac cagctcaccc ttgaatcttt gggcaaatcc 120

aagaactctc ccaggctaag ccccagtctt ggggcttgcc tgtcctgcat catctggcaa 180

ccagcaaagg gacaaggaca gcggagatgg tggcaattgg cagagaggca agacagcaga 240

gacagagagg cagcaattgg tgagagacaa gagacagcag ttggcaagac agcaagagac 300

ggtgaagcag tctgtgattg aggatgtaag atctgtaaca ctgaggaagt accaataaag 360

agctgctaac act 373

96

gcgaccgctc gtccgccggc ttgaggcccg cggggaggcg cgcaattcgt cggcccgcgg 60

gggggcggcc atcccggcag tcttcgcggc gaccaaggac taccaggaag gggagcggct 120

gggatggcgc gtccgcggcc ccgcgagtac aaagcgggcg acctggtctt cgccaagatg 180

aagggctacc cgcactggcc ggcccggatt gatgaactcc cagagggcgc tgtgaagcct 240

ccagcaaaca agtatcctat cttctttttt ggcacccatg aaactgcatt tctaggtccc 300

aaagaccttt ttccatataa ggagtacaaa gacaagtttg gaaagtcaaa caaacggaaa 360

ggatttaacg aaggattgtg ggaaatagaa aataacccag gagtaaagtt tactggctac 420

caggcaattc agcaacagag ctcttcagaa actgagggag aaggtggaaa tactgcagat 480

gcaagcagtg aggaagaagg tgatagagta gaagaagatg gaaaaggcaa aagaaagaat 540

gaaaaagcag gctcaaaacg gaaaaagtca tatacttcaa agaaatcctc taaacagtcc 600

cggaaatctc caggagatga agatgacaaa gactgcaaag aagaggaaaa caaaagcagc 660

tctgagggtg gagatgcggg caacgacaca agaaacacaa cttcagactt gcagaaaacc 720

agtgaaggga cctaactacc ataatgaatg ctgcatatta agagaaacca caaggaaggt 780

tatatgtttg gttgtctaat attcttggat ttgatatgaa ccaacacata gtccttgttg 840

tcattgacag aaccccagtt tgtatgtaca ttattcatat tcctctctgt tgtgtttcgg 900

ggggaaaaga cattttagcc ttttttaaaa gttactgatt taatttcatg ttatttggtt 960

gcatgaagtt gcccttaacc actaaggatt atcaagattt ttgcgcagac ttatacatgt 1020

ctaggatcct tttatcaagg cagttatgat catcgttttc ctgccttgac cccaccatca 1080

tcaaacactc agttaaatat aaattaacat tttttagatg accactcaac ataatgctta 1140

agaatggaat ttcctctctg tgacagaacc caggaattaa ttcctaaata cataacgttg 1200

gtatattgaa gacgaaatta aaattgtcct tcagttttga ggccatgtgt aaagtttaac 1260

catattgtaa aatatctatt ccgtattaga aatagctagt tgacagctta tacttctcaa 1320

aattcatatt gttatgtaca caaactaagt ttctatatgt gaagttagtg agtctttttg 1380

tgttactcca aaataaaggc aatgatttat ttttttccca gtgccaatac aattttgagc 1440

taagcactca aggtggatac tttacatttt aaagctggaa tcagcaacag ccctatggga 1500

aaccagacaa agcattgact tttaaatgta gacttttaaa ataaactgtt ttcttttgga 1560

actacaatta gaatagttaa tattcatcct taaaccatta ttatgtgtac attattgttg 1620

ctattgtgat aatagagaat tttatttatt tttatgccag cttatattgt gagaacacat 1680

ttagtcagtt tgggttttat caatcctgtt aatgcttgtc cttggaacat ctttcgcgta 1740

ttcacggttt gtagttgaaa agtttactgt aaaaaaatca aaaacaaaaa aatgtattgt 1800

ttttacagaa taaatttatt ggaatgtgta ctgggagtaa gatttgaggt tgtaagcaaa 1860

ctaagttagt gtaatttggc ttcatatatg taacgtgagg tattaatgta attcatatat 1920

taaagcaaaa attgttcaca gcaagctgac aatagaatca agtgcaggtg agggtttttc 1980

tttanctttc tntaatnttt tttaaacact ctctgggttt tagattattt gaaaacactg 2040

taggggatga tggggagatg actacatgat ttgcttacac ttacatattt accagcccag 2100

tggaccctag attttgtaat ttgatattat ccatgcattg atttgtatcc cattttcttt 2160

tggttttctt gatgagagct aataaaaaca tgagaaaatg tgagcagacc taaaagccta 2220

gggccgttaa taatgatgat ggtgatgatg gcagctaagg gtatgaaagc accagtccat 2280

ttatcattcc agggcacagt gaggaggtgg ctgtttgtat ttttggtgtg tttctttcat 2340

ttagtgaata ctgattttct ctagtatact caacatacaa tcccaaacat gaaaagttca 2400

taaaaagata gtagggatgt cgatctaata cttcttcctt aaaaggtcct ttttaatttt 2460

gaatatttga atgtattttt taattaatga aatttaattc atcaaaagac ctcttcattg 2520

ctcacactga aacataaggg gaatgtagat ggcattttga attggaatat acaactcaca 2580

aattttcttt aaaagcgttt tatgtgtata tatgaaatgt ttcaaattta ataagatttg 2640

tctttataag aggccaaaaa taattttatt aaaaatatac acagaaatac aatagaaata 2700

tttccagcca ccaataaaac aaatgttcat taaggataga gataaagtta ctgatcccta 2760

tttagctgtt taaattcaca caaaaaaatt tagtaaaagt aattttcttg aaacagcagc 2820

aaataataaa ctttccttgg gaaaacattt ttcaaacaac atttaaaaat attctgatga 2880

tttgcctttt atattgagtt taataatgaa gcatattcat cttatttgca aaagttactc 2940

ctccagtctg cattcactgt tttgaatttt ttaatatgca caggccatat tctcttttga 3000

atagtttcat ttcatgctca ctactgttgg cactaaattg taatttttta cacttataat 3060

tattttatat gtcaaacaat attgagatgg atgatcaagt ttattcacaa atgattttga 3120

atatatttct ttaaacaaac tgtttctcaa gaatttccat tttccttcaa aaaaaattta 3180

cacaatacca tatagctcac acatacagtg cagagcaaga atgtacatat tcttaagtac 3240

tcacgtatga gaagagagtg aaatgggaca aaatatcagt accagtataa caaaagttag 3300

taatttagaa aggaggaaca tgaagtaata tttttattcc actttttctt ctgcctttgt 3360

ttttatgaag aactctggtt tgtagataca acgataggcc aagagctgag gaagaactcc 3420

atatgctatg tttaatgcta aaaaaaggat ttttgcttct tcagggactc tgtagacata 3480

agcagttcta gcatgaagag atgcaccaat gtgagaaaac tgagcctgag ccagacctcc 3540

agcatgtatc aatgtgatgt caggcatcca ggaacatcca ggaaccacta agccatacag 3600

tgcagtcaca aagtaaggaa cagaatagaa catatatgcc agcatctgaa ttttaggata 3660

agcagcagga tcctttagat agggctcttg aaattgcgta tataatcggc agagctcaga 3720

tgggcaatcc aaagcaatca aacctctgaa caggcaaaat ccagttgcca ggaggagaca 3780

cacaaccaac attaaatcaa atggtcttct cagcaggtct ttcgcttggg cttcttgaat 3840

aacctttgag gggtaattat aattttctga tggctgatta tagattctga aaccagccca 3900

gacaggaaga caagtatatg gtatgcttaa gaaaaaagca gggcaaattc gtgttccata 3960

cttccctaca atgtttcctg gcacaaaaac aacaacactc ataataatag atccaaccca 4020

atataggcca atggttctat aagtttcctc ccatgctatg gctgccacca tcaccaggta 4080

catcagataa tgagcagagc catcccagta gcagatcatg tgcccatatg cggtgttcag 4140

atacggttca ccctctctca agtagtgtgt catgaacccg tcaatgattc catcttgctc 4200

cagtcctatg atgaggttca ccacgctggt aaatccaaaa actgcataca catagaacag 4260

tgggtcccgg ggtggttttc ttttgacgag gacacgagcc agcagtgcta ccaggaacag 4320

gatgagggca gcaaccccta caatagtcca ggaatcatgc tgggccgcca ggtggttgaa 4380

gacataggtg accgggatgg ccgagcaggg acagcacgaa gaccccggtg gccgcagagg 4440

cactcatcgc agccgccgcg ccgctcgccc ttcaccgcat cccgctg 4487

97

atacaaataa tgccagactt aaaatttaaa gacatcatat tattttagaa gccgtttaat 60

tatggtatga agtagaaggt tcctctagcg agacaactgc cagtcatacc agcttctgcc 120

aacggaccac ctcacagggt tgttgtgagg agcatatgaa accaaatcag gaaacagccc 180

atcacagcac tgcagcacag aataaaatcc atgctggttg agatgtccca ttatatttgc 240

acaaatgtgg ttcatcgctg gtcgaagact ttcacctttt ccccgaagaa ttttccacgt 300

tgaagtgtct gtgaaggtga caagcatcgt gaggtacagg gtgatgagtc gggagtcctg 360

caggatttca ggcttgagct gcttgagaaa atcacagcag taccacaaaa tgttcttgat 420

ctgttgaatc caaaggaggg tgaggtcctt agaacaagcc agggacacat accacacctt 480

aggctcattc tcagcatcca tgctgctcag gatgctgcga cacaacttct caaatctctc 540

attatcctct ttgattctga ataggaacag cagtttcctg gcaatcttga aaatacaaag 600

tgcacttctt ttagtggact cagggtcatc tgctttaaaa aagtcatcaa tctctctcct 660

gatatctctc tgcagtcgac tccgacagag aaaactccgg acatgggcct ggatcacaac 720

agctgcccgc tcccgttcct tctgcacaag cctttcttct cgtgctgacg ggctctatcg 780

atgaaccatg ctctcgaggt ctgagacagg gtgaacatgt ttgcaaactt gcacaaaccc 840

tgaggacctg cctgtgtcgc agaaatgcca ggtaatcatt agtgatcttg cacaggactc 900

gtggctgaga acagcttctc acttcagaaa agcttgttat tttttcttta ttcgccggag 960

gtccccgcac ttggggtcgg ggccgcagct gccactgtct cagcccaaaa cacccgagtt 1020

ctgccagacc cggggcagca gccgacgcac taccgc 1056

98

gcggccgcgg ccgtgagcct gcccccaact cgccctcagc cgggctggcc ggcgcggcca 60

tggaggtcta catcccgtcc tttcgctatg aagagagcga cctggagcgg ggatacacgg 120

tgtttaagat agaagtgcta atgaatggaa gaaaacattt tgttgaaaag agatacagcg 180

aatttcatgc tttgcacaaa aagcttaaga aatgtataaa aactccagaa atcccttcta 240

aacatgttag gaactgggtc cccaaagtct tggaacagcg acgacaaggc ttggaaacat 300

acttacaggc tgtcatttta gaaaatgaag aacttcccaa actgtttctt gatttcctaa 360

atgtgcgaca cttgccctct ctaccaaagg cagaaagttg tggatctttt gatgaaacag 420

agtctgaaga gtcaagcaaa ctgtcccacc agcctgtgct gctgttcctc agggatccat 480

atgtcttgcc tgcagccagc gattttccaa atgtggttat tgaaggagtc ctccatggga 540

tattttaccc tcatctacag cccaggtaga aatcctacat ggctaaaaga agcagaagca 600

agtttcgaag tcacagtcaa ggaaatcaat acctaccaat ttaacctaaa cgctatgata 660

tataacagct ctagctagtg gtaaagtgca cagtcccagc ttaattcagg gcagggacat 720

ttccattaga atggtgctct taaaaataga aactgaaccg gggcggtggt caggctaagg 780

ccaagtgttt aagaagtaga gtgtagctgc cagcgtagaa acccatgaaa aggaggccac 840

aggagattcc tgggagcact gggtgtagca aaacaaagcc actctctgct tcagtcgcac 900

catttgctaa ttgaaaatca tatcctgaat catactgaga ctgatcaact ttggtagctt 960

ttttgttcag atcttatgac acactactct tctcaccgtg agattttctc agccagtgat 1020

agtacattct gaaatgctgg caccaggaga cggccacaga cacacactgc taaatgtgaa 1080

gatggaacta aactggaaat taaattatac tgacaatatt atggcatttt taagatcatg 1140

gcattttaat ttacattaga gtggagttgc atcatactca ggggttagct tccaaggtca 1200

gtacataggt aaaatgggct attaggatga tccttgaaag ccctttagaa gggtgccatg 1260

ttggaaacct gtacatccac aacaagtagc ttttcctcct atgttggaaa aaaagactgt 1320

ttctttgttt gaagaccaag tgaagttgtt ggtgtttgtt taggggccat tttgttaaaa 1380

aaaaaaaaaa aaaaagcaca taacttttaa cactagaatc agcccgcaag atgcttgccc 1440

cgctagtggc agatgtgaac tgacaaggag tgaagcgccc acccagcgga tggacagcac 1500

ccacctgggt ttactcaagg gtgtgcattc attttaggtg ggatcgccac aggatttcat 1560

gttattttcc ttacggcttc cttttcactg acctcatttg ttgagttaat gtaagttaaa 1620

tgtgtttatg atataactcc actgtacatc atcctttgag tagtaaagga taaaagcata 1680

tatactacct atatgtatgt gctgtatgtg ggcatttcat tgagatctaa ttaatagcta 1740

gcctatttat ggttattcgt tttagtaagt tctgtgggag caaggtattt aaaatcaaaa 1800

ctaataacta catcatggtt tttgattagg atctaaatat tcaggtttta agcctgctgc 1860

aaacttttaa aatattatga tagattctgt actacatgtg ggaaacaagc aagaactaaa 1920

taatcaaatg ttgtcaacca aaagtaatag ttgggtattg gagatttttt taaaatgttt 1980

ttatgttatt agctatttgg agttaaataa aaacagaaca aggaaac 2027

99

cacaacgggg ccgctgagcc cgagcctgag gccgagactg ccagangaca tccagggggc 60

agtaccacac cctgcaggct ggcttcagct ctcgctctca gggcctgagt ggggacaaga 120

cctcgggctt ccggcccatc gccaagccgg cctacagccc agcctcctgg tcctcccgct 180

ccgccgtgga tctgagctgc agtcggaggc tgagttcagc ccacaacggg ggcagcgcct 240

ttggggccgc tgggtacggg ggtgcccagc ccacccctcc catgcccacc aggcccgtgt 300

ccttccatga gcgcggtggg gttgggagcc gggccgacta tgacacactc tccctgcgct 360

cgctgcggct ggggcccggg ggcctggacg accgctacag cctggtgtct gagcagctgg 420

agcccgcggc cacctccacc tacagggcct ttgcgtacga gcgccaggcc agctccagct 480

ccagccgggc aggggggctg gactggcccg aggccactga ggtttccccg agccggacca 540

tccgtgcccc tgccgtgcgg accctgcagc gattccagag cagccaccgg agccgcgggg 600

taggcggggc agtgccgggg gccgtcctgg agccagtggc tcgagcgcca tctgtgcgca 660

nctcagcctc agcctggctg actcgggcca cctgccggac gtgcatgggt tcaacagcta 720

cggtagccac cgaaccctgc agagactcag cagcggtttt gatgacattg acctgccctc 780

agcagtcaag tacctcatgg cttcagaccc caacctgcag gtgctgggag cggcctacat 840

ccagcacaag tgctacagcg atgcagccgc caagaagcag gcccgcagcc ttcaggccgt 900

gcctaggctg gtgaagctct tcaaccacgc caaccaggaa gtgcagcgcc atgccacagg 960

tgccatgcgc aacctcatct acgacaacgc tgacaacaag ctggccctgg tggaggagaa 1020

cgggatcttc gagctgctgc ggacactgcg ggagcaggat gatgagcttc gcaaaaatgt 1080

cacagggatc ctgtggaacc tttcatccag cgaccacctg aaggaccgcc tggccagaga 1140

cacgctggag cagctcacag acctggtgtt gagccccctg tcgggggctg ggggtccccc 1200

cctcatccag cagaacgcct cggaggcaga gatcttctac aacgccaccg gcttcctcag 1260

gaacctcagc tcagcctctc aggccactcg ccagaagatg cgggagtgcc acgggctggt 1320

ggacgccctg gtcacctcta tcaaccacgc cctggacgcg ggcaaatgcg aggacaagag 1380

cgtggagaac gcggtgtgcg tcctgcggaa cctgtcctac cgcctctacg acgagatgcc 1440

gccgtccgcg ctgcagcggc tggagggtcg cggtcgc 1477

100

gaaaattctn gaaaaattnt taaagcctcc gttaagggtc caattccnag caaaacaggc 60

ttgttcacca agcaaagggt tgatccctna cgtgaaggcc acaagcagcg ccggccncgg 120

ctgntctggc gatctnactt ttgggccttc ttcctcttct gctcgctccc tctccccgca 180

ctacaggccc agtgagaagg cggtcaaaca tcgactcagg aacaaaacca gactgcttaa 240

ctatatcagt ccagtctgga gcaactgcaa attcaggatt ttcttccagc cacctggggt 300

agatccttca ttggaggcgc catagctcca cccatcttct tcccatttcg tttattgaca 360

acagggcacc ctttcttctc ctgtcaaagt gtttatatcc aatttattag ggtttccgac 420

atctatgtcg tttctgtttc ggtttctgaa atgaggaaaa cagcacatct gcattctttg 480

gtacataact tggcatatca acagtgtaag tagggtgcag cttcagccat tcaactaaat 540

ccttattttt aggagcatct tcccccacca gcctagtccc atcttcaaga ttgataacag 600

ggatccgtgt 610

101

ctacagcttc nnngnnnttt ttttnttttt tttcnatttt tgccagactc ttgatactct 60

taaaacttgt ttgtggtcag cacaacaagg aacaaaacaa agctttgaaa aaaactttaa 120

catgaaaaaa cgcactgaca ttttttttta tttaatatag cctggacttt acctgcgtat 180

gcacatgctc aagaattgtc tactaggctg actatgtatc acctcttcag cttggatcca 240

attgtggatt tatttacaaa catcaaatgc cttcaagcca atcctttttg ctgtatgttt 300

tgcagcctac tgtagtagat acgcaacaga taatgtggga aaaaaagaga taagaggagg 360

aagctaataa gagactgtca agattgtata ccttcttggt ttcttttaag aatttgttgc 420

ctttctacta ttacagcaaa gcagcatttt gttactgact gcctaaaatc acttaatctc 480

aggtgaacgc atcacttgcc aaactgttgg aatgctattt gtgttttgtt gcactggttt 540

ttttcggttg tttgtttgtt tatttggttg gctttttgga gagggaaatt tggaaacggg 600

acatacacaa aaggttacac acccacattc cctttttatc atgacataca agaagaaact 660

agcagagcta agaatggagt gaagaaaggc agtatggcag gcaccagcaa agagttgagg 720

gctgttgctc ttaaaaaatt atttttttta ttattatttt gaaagtatgg aagttttcca 780

ttcactgggg aaaggaggga aaagtgcatt tatttttata cagagttact taattacctc 840

caaaacacat atgttggaaa tcgcttttgc tggtgcaaag tatattaatg agcaggaata 900

catacattga ggttatgaat agagagctca atttgtacct ttgctgtctt gctcaagctt 960

ggtatggcat gaaaactcga ctttattcca aaagtaactt caaaatttaa aatactagaa 1020

cgtttgctgc gataaatctt ttggattttt gtgtttttct aatgagaata ctgtttttca 1080

ttacctaaag aacaatttgc taaacatgag aaatcactca ctttgattat gtatagatta 1140

cataggaaga acaatcacat cagtaagtta tagtttatat taaaggtaat tttctgttgg 1200

ctcataacaa atataccagc attcatgata gcatttcagc attttccaag gtaccaagtg 1260

tacttatttt gtngttgttg ntgttgtngt attttagaag gaattcagct ctgatgtttt 1320

taaagaaaac cagcatctct gatgttgcaa catacgtgta aaatgggtgt tacatctatc 1380

ctgccattta accccacagt taataaagtg gctgaaaata atagtagctc tggcttggtg 1440

cttgacctgg ttaaatactg tcttaaagct catacaaaac aaataggctt ttccataagt 1500

ggcctttaag aaaacatgga agacaattca tgtttgacaa atgctgacag ggtgaagaaa 1560

gcccagtgta aaaatgaatc gcgttttaag tgattcggtt aaagagtttg gggctcccgt 1620

agcaaactaa tactagataa taaggaaatg ggggtgaaat atttttttat tgttgaatca 1680

ttttgtgaat gtccccctca aaaaaagcta atggaatatt tggcataaag ggcatttggt 1740

ggttttattt ttgtttgagg gggattgtca gaaaatccct tttctctctt acgtctaact 1800

gactagggaa caattgttga tatgcatagc attggaatac ttgtcattat atactcttac 1860

aaataacaca tgaagcaaga atgaccaata ttctgataat tggcactgga tcacaaaatg 1920

tgataaaact ttaaatgtat aaaactttat caaataaagt tttattttcc cctttaaaat 1980

gtatttcttt agaggcatta cttttttaaa aatattggtc aattcctgac ataagatgtg 2040

aggttcacag ttgtattcca gtattcaaga tagattcctg atttttcaat taggaaaagt 2100

aaaatccaaa atgttagcaa aacaaagtgc aatattaaat gtttgcttta tagattatat 2160

tctatggctg tttgtaattt ctcttttttt ccttttttat ttggtgctga atatgtcctt 2220

gtaggctctg ttttaagaaa acaatatgtg ggaaatgatt taatttttcc tattgctctt 2280

ccttgtggaa aataaagtgt tttgtttttt tctgttttgt ataattgttt ggagatttat 2340

ttgaatcttg atcatattag taactcacca tacatgcaaa cacattaaat taaactatta 2400

anctctatt 2409

102

aagaagctag tgcggncagg cagagaagat gggctacaag gccatatttg tgacagtgga 60

cacaccttac ctgggcaacc gtctggatga tgtgcgtaac agattcaaac tgccgccaca 120

actcaggatg aaaaattttg aaaccagtac tttatcattt tctcctgagg aaaattttgg 180

agacgacagt ggacttgctg catatgtggc taaagcaata gacccatcta tcagctggga 240

agatatcaaa tggctgagaa gcactgacat cattgccaat tgttgcaaag ggcattttga 300

gaggtgatga tgcccaggga ggctgttaaa catggcttga atgggatctt ggtgtcgaat 360

catggggctc gacaactcga tggggtgcca gccactattg atgttctgcc agaaattgtg 420

gaggctgtgg aagggaaggt ggaagtcttc ctggacgggg gtgtgcggaa aggcactgat 480

gttctgaaag ctctgctctt gtgccaaggc tgtgtttgtg gggagaccaa tcgtttgggg 540

cttagcta 548

103

cagcctgcca cttgcctccc tgcctgcttc tggctgcctt gaatgcctgg tccttcaagc 60

tccttctggg tctgacaaag cagggaccat gtctaccttt ggctaccgaa gaggactcag 120

taaatacgaa tccatcgacg gaggatgaac tcctcgcctc cctgtcagcc gaggagctga 180

aggagctaga gagagagttg gaagacattg aacctgaccg caaccttccc gtggggctaa 240

ggcaaaagag cctgacagag aaaaccccca cagggacatt cagcagagag gcactgatgg 300

cctattggga aaaggagtcc caaaaactct tggagaagga gaggctgggg gaatgtggaa 360

aggttgcaga agacaaagag gaaagtgagg aagagcttat ctttactgaa agtaacagtg 420

aggtttctga ggaagtgtat acagangagg aggaggagga gtcccaggag gaagaggagg 480

aagaagacag tgacgaagag gaaagaacaa ttgaaactgc aaaagggatt aatggaactg 540

taaattatga tagtgtcaat tctgacaact ctaagccaaa gatatttaaa agtcaaatag 600

agaacataaa tttgaccaat ggcagcaatg ggaggaacac agagtcccca gctgccattc 660

acccttgtgg aaatcctaca gtgattgagg acgcttggac aagattaaaa gcaatgaccc 720

tgacaccaca gaagtcaatt tgaacaacat tgagaacatc acaacacaga cccttacccg 780

ctttgctgaa gccctcaagg acaacactgt ggtgaagacg ttcagtctgg ccaacacgca 840

tgccgacgac agtgcagcca tggccattgc aganatgctc aaagtcaatg agcacatcac 900

caacgtaaac gtcgagtcca acttcataac gggaaagggg atcctggcca tcatgagagc 960

tctccagcac aacacggtgc tcacggagct gcgtttccat aaccagaggc acatcatggg 1020

cagccaggtg gaaatggaga ttgtcaagct gctgaaggag aacacgacgc tgctgaggct 1080

gggataccat tttgaactcc caggaccaag aatgagcatg acgagcattt tgacaagaaa 1140

tatggataaa cagaggcaaa aacgtttgca ggagcaaaaa cagcaggagg gatacgatgg 1200

aggacccaat cttaggacca aagtctggca aagaggaaca cctagctctt caccttatgt 1260

atctcccagg cactcaccct ggtcatcccc aaaactcccc aaaaaagtcc agactgtgag 1320

gagccgtcct ctgtctcctg tggccacacc tcctcctccn cgggactcct ccactcccag 1380

agaaaaagct cattaccaga aacattgcag aagtcatcaa acaacaggag agtgcccaac 1440

gggcattaca aaatggacaa aaaaaagaaa aaagggaaaa aggtcaagaa acagccaaac 1500

agtattctaa aggaaataaa aaattctctg aggtcagtgc aagagaagaa aatggaagac 1560

agttcccgac cttctacccc acagagatca gctcatgaga atctcatgga agcaattcgg 1620

ggaagcagca taaaacagct aaagcgggtg gaagttccag aagccctgcg ataaaaacat 1680

gatctttaga agaggatgca gaactgttca gtggtattac atgaaatgca ttgtgagatg 1740

tttctaaaat accttcttca attcaaaatg atccctgact ttaaaaataa tctcacccat 1800

taattccaaa gagaatctta agaaacaatc agcatgtttc ttctgtaaat atgaaaataa 1860

atttcttttt tatgtcgtga gatttgtatt ggcaagaagc agttaattta aagatgctct 1920

tcctatctgt ggatgtgttg gtaactccga gttgtaatga gttcatgaaa tgtgctgtta 1980

tttttgtaat ctcaataaat gtggattgaa gttttttccc tttttttaaa gccaaactaa 2040

tatttttctg tgacttgata catctgtcag atttttgtaa tctcgataaa tgtgtattga 2100

agttttttcc ctttttttaa aaagccaaac taatattttt ctgtgagtta atacatctgt 2160

caggtgtgta tgtaacatta ctggacatta aaaaaaatta ttacattctc acccaaaaag 2220

ggtttgggtc ctaagcattt gcctttcttt gtttcctctt gttcaagaaa atctgattag 2280

a 2281

104

ggtgtccatg gcccgcaccc ccaagctgcc actgcagcag tcagagtggc agctgaaggc 60

tcggttcatg ccgtgccccc gggcagttct ggtgaggcta agcaagaggc ctctgcatct 120

tgacacctag gagagcaggg acggagtctc ccagggtgga ggaccatgct gcgccgcaag 180

ccctccaatg ccagtgagaa ggagcccact cagaagaaaa agctctccct tcagcgctcc 240

agcagcttca aggattttgc caaatccaaa cccagctccc ccgtggtgag cgagaaggag 300

tttaatctgg atgataacat tccagaagat gactcaggtg tccccacccc agaagatgct 360

gggaagagtg gcaaaaagct ggggaagaag tggagggcag tgatttcccg aaccatgaac 420

aggaagatgg gcaagatgat ggtgaaggcc ctgtcagaag agatggcaga cactctggag 480

gagggctctg cctccccgac atctccagac tacagcctgg acagccctgg ccctgagaag 540

atggcgctgg ccttttctga gcaagaggag catgaacttc cggtgctcag ccgccaggca 600

tcaacaggca gtgagctctg cagccccagc ccaggttctg gcagcttcgg ggaggaacca 660

cctgcccccc agtacacagg gcctttctgt ggccgggcac gagtccacac cgacttcact 720

cccagcccct atgaccacga ctcgctgaaa ctgcagaaag gagatgtgat ccagatcatt 780

gaaaagccac ctgtgggcac gtggctgggc ctactcaatg gcaaggtggg ctctttcaaa 840

ttcatctatg tggatgtgct gcccgaggag gccgtggggc atgcccgccc cagccgccga 900

cagagcaagg gcaagaggcc caagcctaag accctggcat gagctgctgg agcgcatcgg 960

cctggaggag cacacatcca ccctcctgct caatggctac cagacactgg aagacttcaa 1020

agagctgcga gaaacacacc tcaatgagct gaacatcatg gatccacagc accgggccaa 1080

gctgctcacg gccgccgagc tgctgctgga ctatgacact ggcagtgagg aggctgaaga 1140

gggcgccgag agcagccagg agccagtggc acacacagtg tcggaaccca aggtggacat 1200

cccgcgcgac tcaggctgct ttgagggctc ggagagcggg cgcgatgacg cagagctggc 1260

aggcactgag gagcagctgc aaggcctctc cctggccggg gcaccttgag gtggcggtgg 1320

caataggcca aggctgggac ccagctgcaa aggctgtagg agtgggccca gcctcccgtg 1380

gtggcccagg ccctgaggac tggcactgag cctggccctg cttccccagg gacacttagg 1440

gccacagagg ccaggccagg gccctacagg ttccaggctc agctggagtg gttggggagt 1500

cgcccaaggg cacatcccac ctgcctgagc cccgcccttc caccagcgac tgacagcgca 1560

gccctcctgg caccaactgc tcccctgcca tggccacggc cacagcaagt ggggcactgg 1620

gaaaccctgc ccatgtccct caccaacaag gcctccaaat cctcctcacc cccacaccac 1680

ctacccctgt cgcactgctc ctgaaaaggg ggccaagtca atgtttcagg tcagtctaaa 1740

aaccctaggg aagctggcca tttaaaagaa cccaaactga ccatgggtaa atccagttcc 1800

cctaaataag gcctgaagaa atccacaggt accattccca ctttccttct ccctagcttt 1860

cttagaggtt tggccactaa atcttatgag acttgaacca agtggcttcc tctttctagg 1920

cttaggacgg gttggggtta gaaagggtga tcactgaagg ccttgcctgc tctgacattc 1980

tgtgacatta aatgtctatt ctcctgttac ctgtggcctg ggacaccagt ggggtttatc 2040

gaggggacca gaggggcctc aggctttcag atgaaatggc tcctcctact cacccacttt 2100

attcctctcc atgtaattca ggacaagctg caacttcccc cagcttaaca caatgcccat 2160

acctcatacg atatgcgccc tcccgttcca tccctggccc cctcaaacga gacttctcac 2220

aaggctgatt acagatggtc aaacctggct tccaaggaca gaattgcctc tcggaagcca 2280

gctgtggatc tgagtccaga gttggccact tgtgtgggtc ctcacaagca aagagagcac 2340

taaacttgac attgggggtc caccactcca actttgcttt ctgaaggttt tggtgtacat 2400

tgagccccag aaggaaagga gagtatctgt gagtgggggc ctcccttgac cccagtacga 2460

agtctatgcc ctgaatcccc agagtagccc ttcctggtgc ccaactggcc tggggacaaa 2520

cagcgtccac tacatctagg actgccggct aagtggacac acttcttgac ctcctaccag 2580

gaactttggt aaaagctagc tttggggaag gggttgggtg taaatatgag agggtggagg 2640

gagaccagct ggtagcaata aacatgggta gaactaaatt accgtctcca gttatctttt 2700

ctatggagag agtgttgtgg ggaggggcag accggtctcc ttcaaagctg gcctcagcaa 2760

agtgtccctc actgtccttt caggtccatc tttcccttcc cttaaatgtt cagtgccctt 2820

gactctgctg acctaaagct ccagtctgaa gccctagctg gctctgccct cccctctaac 2880

cagccctcct cagaacaagg ctcaagctcc catgaccacg ggctttgctg gggtccaaga 2940

ggtgtagggg ggaatggcta tttccctcat ccaataactg ttcattttaa cagggccctt 3000

aaagaccttc acccgtgtga agaaaggcct gcactgagga gctgtccagg atctaagagg 3060

gggagatttg gggtcagcat ggcctttcct ctgaagtcac cttttcctgg cccccaccct 3120

gtacccacta aagcagtgnc atctcctggg agaaaaggag aacatataca tagaataaag 3180

actatgaaga tctgcaccaa atgactacta ctggtgatct tgtgaggcgt gtggggtggg 3240

actaggggag tgagggagaa aaatgctcac tttctacatt cttcttttat ttgcacttca 3300

aaagtattat ttttatatct atgaagaaaa ggaaactgca tttcaatttt tgaaaaaaaa 3360

aataaaacta aattaacaaa taaatagggc ccacgcctct ggcctccaat acgggacagt 3420

agcagcaaaa tcattatcct gctgcctttt ggtacacggt tctggaaaga tgagaggtga 3480

ataatggcca aagtgcttaa aatccatgca tgccagcgtg c 3521

105

gcacgttgtg acatcaaaga aagggctcgt gctgggaaag cgggcggggc tgagagcggc 60

cctgcagccg acgcgcatgn cttctatcga cctgcggctg ggtggggggt gcactgggaa 120

aaggggcggg gtcctcagag ctgccgcgct ggcacatctt cctggagaag gggagggtgc 180

ggctgcagag aattgagact tagaagcttt gaattcctgt atctgagaac ggagttcgtt 240

gggggtggtg gagggggttg gaattgggga cctacggaag gtgaggatca gcctccaggc 300

acaacagggg agaggacgtt cagtgggctt caacttgacc caggccttct ccccttcagg 360

ctcagctctt gccaggccaa attgagacat gtctgacaca agcgagagtg gtgcaggtct 420

aactcgcttc caggctgaag cttcagaaaa ggacagtagc tcgatgatgc agactctgtt 480

gacagtgacc cagaatgtgg aggtcccaga gacaccgaag gcctcaaagg cactggaggt 540

ctcagaggat gtgaaggtct caaaagcctc tggggtctca aaggccacag aggtctcaaa 600

gaccccagag gctcgggagg cacctgccac ccaggcctcg tctactactc agctgactga 660

tacccaggtt ctggcagctg aaaacaagag tctagcagct gacaccaaga aacagaatgc 720

tgacccgcag gctgtgacaa tgcctgccac tgagaccaaa aaggtcagcc atgtggctga 780

tacgaaggtc aatacaaagg ctcaggagac tgaggctgca ccctctacag gccccagcag 840

atgaacctga gcctgagagt gcagctgccc agtctcagga gaatcaggat actcggccca 900

aggtcaaagc caagaaagcc cgaaaggtga agcatctgga tggggaagag gatggcagca 960

gtgatcagag tcaggcttct ggaaccacag gtggccgaag ggtctcaaag gctctaatgg 1020

cctcaatggc ccgcagggct tcaaggggtc ccatagcctt ttgggcccgc agggcatcaa 1080

ggactcggtt ggctgcttgg gcccggagag ccttgctctc cctgagatca cctaaagccc 1140

gtaggggcaa ggctcgccgt aggagctgcc aagctccagt tcatcccaag agcctgaagc 1200

accaccacct cggggatgtg gcccttttgc aagggagggc aaatgatttg gtgaagtacc 1260

ttttggctaa agaccagacg aagattccca tcaagcgctc ggacatgctg aaggacatca 1320

tcaaagaata cactgatgtg taccccgaaa tcattgaacg agcaggctat tccttggaga 1380

aggtatttgg gattcaattg aaggaaattg ataagaatga ccacttgtac attcttctca 1440

gcaccttaga gcccactgat gcaggcatac tgggaacgac taaggactca cccaagctgg 1500

gtctgctcat ggtgcttctt agcatcatct tcatgaatgg aaatcggtcc agtgaggctg 1560

tcatctggga ggtgctgcgc aagttggggc tgcgccctgg ggatacatca ttcactcttt 1620

ggggacgtga agaagctcat cactgatgag tttgtgaagc agaagtacct gggactatgc 1680

cagagtcccc aatagcaatc cccctgaata tgagttcttc tggggcctgc gctcttacta 1740

tgagaccagc aagatgaaag tcctcaagtt tgcctgcaag gtacaaaaga aggatcccaa 1800

ggaatgggca gctcagtacc gagaggcgat ggaagcggat ttgaaggctg cagctgaggc 1860

tgcagctgaa gccaaggcta gggccgagat tagagctcga atgggcattg ggctcggctc 1920

ggagaatgct gccgggccct gcaactggga cgaagctgat atcggaccct gggccaaagc 1980

ccggatccag gcgggagcag aagctaaagc caaagcccaa gagagtggca gtgccagcac 2040

tggtgccagt accagtacca ataacagtgc cagtgccagt gccagcacca gtggtggctt 2100

cagtgctggt gccagcctga ccgccactct cacatttggg ctcttcgctg gccttggtgg 2160

agctggtgcc agcaccagtg gcagctctgg tgcctgtggt ttctcctaca agtgagattt 2220

tagatattgt taatcctgcc agtctttctc ttcaagccag ggtgcatcct cagaaaccta 2280

ctcaacacag cactctaggc agccactatc aatcaattga agttgacact ctgcattaaa 2340

tctatttgcc atttctgaaa aaaaaaaaaa aaaaaanaaa anaagnnaaa aaaaag 2396

106

gagtccgctg gcctcactcc tagctcatct ggnccggcgg cggcaactgg nttcagggtt 60

agggtttaaa gaaaggacnc ggaggcagga ggagcagtct cattgttccg ggagccgtca 120

ccacagtagg tccctcggct cagtcggccc agcccctctc agtcctcccc aacccccaca 180

accgcccgcg gctctgagac gcggccccgg nggcggcggc agcagctgca gcatcatctc 240

caccctccag ccatggaaga cctggaccag tctcctctgg tctcgtcctc ggacagccca 300

ccccggccgc agcccgcgtt caagtaccag ttcgtgaggg agcccgagga cgaggaggaa 360

gaagaggang atgaagagga ggacgaggac gaagacctgg aggagctgga ggtgctggag 420

aggaagcccg ccgccgggct gtccgcggcc ccagtgccca ccgcccctgc cgccggcgcg 480

ccnntaatgg acttcggaaa tgacttcgtg ccgccggcgc cccggggacc cctgccggcc 540

gctccccccg tcgccccgga gcggcagccg tcttgggacc cgagcccggt gtcgtcgacc 600

gtgcccgcgc catccccgct gtctgctgcc gcagtctcgc cctccaagct ccctgaggac 660

gacgagcctc cggcccggcc tccccctcct cccccggcca gcgtgagccc ccaggcagag 720

cccgtgtgga ncccgccagc cccggctncc gccgcgcccc cctccacccc ggccgcgccc 780

aagcgcaggg gctcctcggg ctcagtggat gagacccttt ttgctcttcc tgctgcatct 840

gagcctgtga tacgctcctc tgcagaaaat atggacttga aggagcagcc aggtaacact 900

atttcggctg gtcaagagga tttcccatct gtcctgcttg aaactgctgc ttctcttcct 960

tctctgtctc ctctctcagc cgcttctttc aaagaacatg aataccttgg taatttgtca 1020

acagtattac ccactgaagg aacacttcaa gaaaatgtca gtgaagcttc taaagaggtc 1080

tcagagaagg caaaaactct actcatagat agagatttaa cagagttttc agaattagaa 1140

tactcagaaa tgggatcatc gttcagtgtc tctccaaaag cagaatctgc cgtaatagta 1200

gcaaatccta gggaagaaat aatcgtgaaa aataaagatg aagaagagaa gttagttagt 1260

aataacatcc ttcataatca acaagagtta cctacagctc ttactaaatt ggttaaagag 1320

gatgaagttg tgtcttcaga aaaagcaaaa gacagtttta atgaaaagag agttgcagtg 1380

gaagctccta tgagggagga atatgcagac ttcaaaccat ttgagcgagt atgggaagtg 1440

aaagatagta aggaagatag tgatatgttg gctgctggag gtaaaatcga gagcaacttg 1500

gaaagtaaag tggataaaaa atgttttgca gatagccttg agcaaactaa tcacgaaaaa 1560

gatagtgaga gtagtaatga tgatacttct ttccccagta cgccagaagg tataaaggat 1620

cgttcaggag catatatcac atgtgctccc tttaacccag cagcaactga gagcattgca 1680

acaaacattt ttcctttgtt aggagatcct acttcagaaa ataagaccga tgaaaaaaaa 1740

aatagaagaa aagaaggccc aaatagtaac agagaagaat actagcacca aaacatcaaa 1800

cccttttact tgtagcagca caggattctg agacagatta tgtcacaaca gataatttaa 1860

caaaggtgac tgaggaagtc gtggcaaaca tgcctgaagg cctgactcca gatttagtac 1920

aggaagcatg tgaaagtgaa ttgaatgaag ttactggtac aaagattgct tatgaaacaa 1980

aaatggactt ggttcaaaca tcagaagtta tgcaagagtc actctatcct gcagcacagc 2040

tttgcccatc atttgaagag tcagaagcta ctccttcacc agttttgcct gacattgtta 2100

tggaagcacc attgaattct gcagttccta gtgctggtgc ttccgtgata cagcccagct 2160

catcaccatt agaagcttct tcagttaatt atgaaagcat aaaacatgag cctgaaaacc 2220

ccccaccata tgaagaggcc atgagtgtat cactaaaaaa agtatcagga ataaaggaag 2280

aaattaaaga gcctgaaaat attaatgcag ctcttcaaga aacagaagct ccttatatat 2340

ctattgcatg tgatttaatt aaagaaacaa agctttctgc tgaaccagct ccggatttct 2400

ctgattattc agaaatggca aaagttgaac agccagtgcc tgatcattct gagctagttg 2460

aagattcctc acctgattct gaaccagttg acttatttag tgatgattca atacctgacg 2520

ttccacaaaa acaagatgaa actgtgatgc ttgtgaaaga aagtctcact gagacttcat 2580

ttgagtcaat gatagaatat gaaaataagg aaaaactcag tgctttgcca cctgagggag 2640

gaaagccata tttggaatct tttaagctca gtttagataa cacaaaagat accctgttac 2700

ctgatgaagt ttcaacattg agcaaaaagg agaaaattcc tttgcagatg gaggagctca 2760

gtactgcagt ttattcaaat gatgacttat ttatttctaa ggaagcacag ataagagaaa 2820

ctgaaacgtt ttcagattca tctccaattg aaattataga tgagttccct acattgatca 2880

gttctaaaac tgattcattt tctaaattag ccagggaata tactgaccta gaagtatccc 2940

acaaaagtga aattgctaat gccccggatg gagctgggtc attgccttgc acagaattgc 3000

cccatgacct ttctttgaag aacatacaac ccaaagttga agagaaaatc agtttctcag 3060

atgacttttc taaaaatggg tctgctacat caaaggtgct cttattgcct ccagatgttt 3120

ctgctttggc cactcaagca gagatagaga gcatagttaa acccaaagtt cttgtgaaag 3180

aagctgagaa aaaacttcct tccgatacag aaaaagagga cagatcacca tctgctatat 3240

tttcagcaga gctgagctaa aacttcagtt gttgacctcc tgtactggag agacattaag 3300

aagactggag tggtgtttgg tgccagccta ttcctgctgc tttcattgac agtattcagc 3360

attgtgagcg taacagccta cattgccttg gccctgctct ctgtgaccat cagctttagg 3420

atatacaagg gtgtgatcca agctatccag aaatcagatg aaggccaccc attcagggca 3480

tatctggaat ctgaagttgc tatatctgag gagttggttc agaagtacag taattctgct 3540

cttggtcatg tgaactgcac gataaaggaa ctcaggcgcc tcttcttagt tgatgattta 3600

gttgattctc tgaagtttgc agtgttgatg tgggtattta cctatgttgg tgccttgttt 3660

aatggtctga cactactgat tttggctctc atttcactct tcagtgttcc tgttatttat 3720

gaacggcatc aggcacagat agatcattat ctaggacttg caaataagaa tgttaaagat 3780

gctatggcta aaatccaagc aaaaatccct ggattgaagc gcaaagctga atgaaaacgc 3840

ccaaaataat tagtaggagt tcatctttaa aggggatatt catttgatta tacgggggag 3900

ggtcagggaa gaacgaacct tgacgttgca gtgcagtttc acagatcgtt gttagatctt 3960

tatttttagc catgcactgt tgtgaggaaa aattacctgt cttgactgcc atgtgttcat 4020

catcttaagt attgtaagct gctatgtatg gatttaaacc gtaatcatat ctttttccta 4080

tctgaggcac tggtggaata aaaaacctgt atattttact ttgttgcaga tagtcttgcc 4140

gcatcttggc aagttgcaga gatggtggag ctagaaaaaa aaaaaaaaaa aagccctttt 4200

cagtttgtgc actgtgtatg gtccgtgtag attgatgcag attttctgaa atgaaatgtt 4260

tgtttagacg agatcatacc ggtaaagcag gaatgacaaa gcttgctttt ctggtatgtt 4320

ctaggtgtat tgtgactttt actgttatat taattgccaa tataagtaaa tatagattat 4380

atatgtatag tgtttcacaa agcttagacc tttaccttcc agccacccca cagtgcttga 4440

tatttcagag tcagtcattg gttatacatg tgtagttcca aagcacataa gctagaagaa 4500

gaaatatttc taggagcact accatctgtt ttcaacatga aatgccacac acatagaact 4560

ccaacaacat caatttcatt gcacagactg actgtagtta attttgtcac agaatctatg 4620

gactgaatct aatgcttcca aaaatgttgt ttgtttgcaa atatcaaaca ttgttatgca 4680

agaaattatt aattacaaaa tgaagattta taccattgtg gtttaagctg tactgaacta 4740

aatctgtgga atgcattgtg aactgtaaaa gcaaagtatc aataaagctt atagacttaa 4800

aangnnanna gngaaaaaag gg 4822

107

cttgtgagtc ctcccccttc ctgacatgag tctcagtgcc ggcaaacacg gctggttgaa 60

ccctgagcta gcccagctgc tttgttcacc ttacgtttgg ggaaggctga aattttattg 120

agcaccgact gtattccaca cactcttcta ggtgcccgaa atatgctgtt aaacaaatac 180

tcagccctca tggggctgag agtctggtgg ggaagacctg ttgaaaaaca atcatattaa 240

atgaattgca ttgcatgtta gaagatcgta agtactctgg gggaaaatga gagtagaaca 300

ggataagggg gtgatggagg gaatgagtgg tgattttaaa tgtagttatc a 351

108

ggcaccagtt ggtgtctgag atgccctcca gtctggggaa tcccgtagat tcttagacta 60

ctttgaactg aagtatgtgc agtctgccat ctcacattaa aatgtaggca ttttgtcaat 120

tgcttttctt tcatctgcac aagaggaagg agagaacgaa tcaatacaac cactcttttc 180

cttgagactg caaagaaaat ggttctatag tttgatggtt ctacttccca gatgctacct 240

ctcagattta ttctcaacag aaaatttttt gattacagca gaccagatct ttatctgtca 300

ataagttaaa aaagataatc tgggctggat gtggtggctc acgcctgtt 349

109

agcttagcca tgactcagta actaaaaagt tcaaaaaatc cagttatgta atgtgcagag 60

taacaaattg caagaaaaac aacttaatct tccagtgact aagtaagaaa aactgttgtc 120

actattaaac atgtaggaaa ttgataatta ttacaaacaa agcaatactc taccctaaat 180

ctagacaaat cactggacag atgataagat tttcagcttt ctcctttaaa gagctgtgcc 240

tggctggatg atgggtttta tacacgtttt tatgttattt tagaatgtac agattttttt 300

gtaaacatgc aaagggaagg ttacaaactc cttaaacttt aaaaaaccat aaatcctttc 360

tttgctactt atattctatg ccaattataa tattccaaga cttacctttc ttcagaatgc 420

ttacatatgg aaaggtttat ttataaatat ttgataggta aatattccat atgtattttc 480

tagcccgtct ttctctgtcc ctccctcaaa taacttcatt accctctcct ttttaaacga 540

aatatcttga taataagaaa acaaaatcat ttttttgtga aataatacat atggacaaaa 600

aatacaagtt gtattttact tctggttcat taaaatattg tgtttagttg gattttttcc 660

tcctttattt tcagaaacat aaaagaaatt gttttatttc ctaaaggata aaattggata 720

tagcctcttt agtagacact atcacagttc tgttgtttgc tgtgttcatt tgcttaatga 780

attgcgtgag aacagtcact gtaatgaaat atgtgtgctg ggggtggggg gaagggcatg 840

ggaaatgttt tatgaaaaaa agttataagc ctaanactat gaagtaacat ctaatgcagt 900

tctttttaag tgcaatatat ttatttctgc tagaaatata ttatcaacct tatgtaatat 960

ttgaagcatt acatattatt tgtaaacagc ttaaaattat atattacccc aattgtacat 1020

aagtacaaat gtgtggatat tagtgctgag attacaatga tatggatttc tggtgtagtc 1080

at 1082

110

aaaagttgct gttaggactt tattactatt ctcttttagg atacatcaac atttgaattt 60

taccagcata tgtgacttag ttttcttagt ttttgtcatt tttaagaatc ctggcaaata 120

attttaaata atttatttgt tactaaaatt tgatataacc ttaatgatct ttcagcacat 180

tatcaaatta tttagccatc ctaaaatact tgatgaataa attaatagaa gttaatgttt 240

ctagtttgcc tcacttttct ggaattattc ttattttgca gattagtctt gccaactacc 300

gatgccacag aatttaatta ccaattgcaa agccattttc atagtcataa ttatattcta 360

ggcaatattt tttggtcagg ttctcctcca gtctgcagtc aatgtcctct gcatcactac 420

aaaatgatgg gaccattttt cccagggtcg tctcaaatgc ttcagaaaac ttcttcatca 480

gatctgtgtc atcacaacga gctgctttgt agaacatctc aaaggacttg aacccgtggt 540

ttgcaaaacg ttttttggca cagtctggcc attcagtggt atatgttggt ttccagacgc 600

catcttcata agcacaataa tacttgtcag tagacccttc tgtgaaatca tagccctcca 660

agcaagttaa tgtacagttg actccagtat tatctggagt gcatataaaa tccccattta 720

caggtgtgaa tggaatttca cagggagaac cttttatgac aat 763

111

ggtttaagtt cccctccagc cccgagccag gagcagttct caataccggg agaggcacag 60

agctatttca gccacatgaa aagcatcgga attgagatcg cagctcagag gacaccgggg 120

cgccccttcc accttccaag gagctttgta ttcttgcatc tgggctgcct gggacttccc 180

ttaggcagta aacaaataca taaagcaggg ataagactgc atgaaaaatg tcgaaacagc 240

cagtttccaa tgttagagcc atccaggcaa atatcaatat tccaatggga gcctttcggc 300

caggagcagg tcaacccccc agaagaaaag aatgtactcc tgaagtggag gagggtgttc 360

ctcccacctc ggatgaggag aagaagccaa ttccaggagc gaagaaactt ccaggacctg 420

cagtcaatct atcggaaatc cagaatatta aaagtgaact aaaatatgtc cccaaagctg 480

aacagtagta ggaagaaaaa aggattgatg tgaagaaata aagaggcaga agatggattc 540

aatagctcac taaaatttta tatatttgta tgatgattgt gaacctcctg aatgcctgag 600

actctagcag aaatggcctg tttgtacatt tatatctctt ccttctagtt ggctgtattt 660

cttactttat cttcattttt ggcacctcac agaacaaatt agcccataaa ttcaacacct 720

ggagggtgtg gttttgagga gggatatgat tttatggaga atgatatggc aatgtgccta 780

acgattttga tgaaaagttt cccaagctac ttcctacagt attttggtca atatttggaa 840

tgcgttttag ttcttcacct tttaaattat gtcactaaac tttgtatgag ttcaaataaa 900

tatttgact 909

112

caggaggtgg gcctggagca gggcctcaga agtctcctgg cctttcccat caggaagcac 60

atcctgttgg tgtctggctg ccgcggcagg gccgctattt gttgcggttg gctacgcctt 120

ccagctcacc aaaaacagtc tcaaaaacaa ccatttcctc tctgctgaga gccagggaag 180

gcgagctctg cgcacacggg cgtccctgca gcagccactc tgctttccag gaccggccaa 240

ctgccctgga ggcatccaca caggggccca ggcagcacag aggagctgtg aacccgctcc 300

acaccggcca ccctgcccgg agcctggcac tcacagcagg ccggtgctaa ggagtgtggc 360

gcgggctcga ctcccactgc tgccggcctc ccgagtgact ctgttttcca ctgctgcagg 420

cgagaagagg cacgcgcggc acaggccggc ctccgcttcc cgggaagacg gcgcactcct 480

ggccctgggt tcttgctgct gcccaccctc tgctccctgg gatgggcccc gaggcgagca 540

gcttcagcac aggcctggcc ctgctccagg tgcaggaagg aggataaggc cgggccgaga 600

ggcggcacac ctggaccatc ccatgggcct ccgcccgcgc cgccccgagg atgagtggtg 660

atgtcctcta gccaccccta gcagcgtcgg ctctccctgg acg 703

113

gtggtattat acccaagcct agtgtgtatt acaacttcaa cactcccctt tggcttatat 60

taccatgtgc atagctaaag tcttctattt ttagaacacc ttctgtctgt tctttcccca 120

tcaactcctt cctcatcctt cttggtgttc tgtcatgggc catgggcttg ctatggccag 180

ccttactgat gccaagcagc ttatgggatg ttctttattg tgtgtgatgg tattggtttg 240

tttggtagat aagtgggagg aaaagtactg ttgctacact attataggca tgtttgatac 300

tagcagctaa cactggtcac tccaaagcac tgtttctata ggaacattga agctattaag 360

atgttttgat tatcctaatt acataatgac cgatttgaga tagaggcctt taaatacatt 420

ccatgccctc cccagaaaat agtctgtggg agtcagttgc cttggtgcca ggtatgtgtt 480

ctgatgtagg tcatgagtct ttctacttaa tgggaaggga agaacatttg tttccaggat 540

gactttctgg ccagaatacc ggaaagcttt taggaagctt cgttcacatg ctatttaaat 600

gcacaaaata gacagtaagg atttatctgt tcagtttttc ttcccagtga attaatttca 660

gcttatatgg gtgtcttcat tgaacatgag gaatattagg ttat 704

114

ggccgccctg ttgttttgat gaataatact tggtggggcg agggggaaag agtaggggtg 60

gaggggtagg aggatttact cttccagcga gagctacgcg catcccatcc tccccctccc 120

ccctacccgg gctccggcgt ggaggcgggg cgtggccggc ctgctttggg aggggagggg 180

cttcccttac agtgctgggc tctgccagga cggctgtggg gtcgccttac ctcggggtat 240

ccactctgca gtcgaccagt tcccgccagg agcaaagggt aggaaggaga gcaggatctg 300

ctgtaggaac gcagctaccg cgccactatc acgaagaaac agcaggctcg gggcacgaga 360

cgaactggag accgcgctgc ctagctgggt aacctgggaa gcagagggta ataagtggcg 420

ccttaagaca accctgtagc agcagcagtg gcggccaaag gaggctgctc agggaacaag 480

cggctgtagt agtctgtggg gcgactggag tgaccgaagc caaggcagtt tagtgcctct 540

cgtgttctta ttttttaacc tctgactatg caattctgaa acctccccca ttcgggggac 600

cagacagcct gatagacacc ttccactctc cttcctcccg ccgtggtctc gagaacagaa 660

ggatctctcc ttaacgcctt tcaccattaa gaggaaagcg atggaggagc tgagcgctga 720

tgagattcga cggaggcgcc ttgcacgact tgctggtgga cagacctctc agccaaccac 780

cccactcacc tctccccaga gggagaaccc tccggggcct cccatagcgg catcagcccc 840

aggaccctct cagagtcttg gtctcaatgt ccacaacatg accccagcta cctccccaat 900

aggtgcatca ggagtagccc atcgaagcca gagcagtgaa ggagtcagtt ctctcagcag 960

ctcgccctct aatagccttg aaacgcaatc tcagtctctc tcacgttccc agagcatgga 1020

tatcgatggt gtctcatgtg agaaaagcat gtcccaggtg gatgtggatt caggaattga 1080

aaacatggag gttgatgaaa atgatcgaag agaaaagcgg agcctcagtg ataaggagcc 1140

ttcctcgggc cctgaagtgt ctgaagagca ggccttacag ctggtctgta agatcttccg 1200

tgtctcttgg aaggaccggg acagagatgt catctttctt tcttctcttt ctgcacagtt 1260

taagcagaac ccaaaagaag tattctccga ttttaaggac ttgattggcc agattttaat 1320

ggaagtgcta atgatgtcca ctcagaccag agatgaaaac ccatttgcca gtctgacagc 1380

cacatcacag ccaattgctg cagcagcacg gtcaccagac agaaatctct tgctaaacac 1440

tggctccaat ccaggaacaa gccccatgtt ctgcagcgtg gcttcctttg gtgccagctc 1500

tttgtctagt ttgggagcct ctggtggagc aagtaattgg gattcctaca gtgaccattt 1560

caccattgaa acctgcaaag agacagatat gctgaactac ctcatcgagt gtttcgaccg 1620

agttggaata gaggaaaaaa aagcaccaaa gatgtgcagc cagccagcag tcagccagct 1680

tctgagcaac atccgctcac agtgcatatc ccatactgct ttagtactac aaggctccct 1740

aacacagccc aggtccttgc agcagccgtc cttcctagtg ccgtatatgc tgtgtaggaa 1800

tctcccatat ggcttcattc aggaactggt gagaaccact caccaggatg aagaagtgtt 1860

caagcagata tttatcccca ttttacaagg cctggctctt gctgccaaag agtgctccct 1920

cgacagtgac tactttaaat accccctcat ggcactaggt gagctctgtg aaaccaagtt 1980

tgggaagaca caccctgtgt ggcaatttgg ttgcttcttt gcggttgtgg ttgccgaaat 2040

ccttaagtcc tggctgtggg cgggagctgc agagactctc ttacttaggg gctttcttta 2100

gcttctcagt ctttgcagaa gatgatgtta aagtggttga aaaatacttc tcagggcctg 2160

ccattaccct ggaaaacact cgtgtggtta gccaatcatt gcagcattac ttagagctcg 2220

gaaggcaaga gctttttaag attctgcata gtattttgtt aaatggcgaa acccgtgagg 2280

ctgctctcag ttacatggcg gctgtcgtca atgccaatat gaagaaagca cagatgcaga 2340

cagatgatag attggtgtct acagatggat ttatgctgaa tttcctttgg gtactgcagc 2400

agctaagtac aaaaatcaag ttagaaacag ttgatcccac gtatattttt cacccaagat 2460

gtcggattac tcttcccaat gatgagacgc gtgtgaatgc aacgatggaa gatgtgaatg 2520

actggctgac tgaactctat ggcgatcagc ctccattttc tgagccgaaa ttccctacgg 2580

agtgcttctt tctcaccctg catgctcacc acctctctat tctgcctagt tgccgtcgct 2640

atatccgcag actccgggct atccgggagc tcaatagaac tgtagaagat ttgaaaaata 2700

atgaaagcca atggaaagat tccccactgg caactagaca ccgcgaaatg ctgaagcgct 2760

gtaaaactca gcttaagaaa ctggtacggt gcaaggcctg tgctgatgct ggcctacttg 2820

acgagagctt cctgagaaga tgtctgaatt tttatggcct tctcattcag ctgctgctcc 2880

gcatcctgga ccccgcatat cccgatataa cactgccttt aaattcagat gtccccaagg 2940

tatttgcagc gttgcctgag ttttatgtag aagatgttgc agaattttta ttttttattg 3000

tacaatactc tccccaggcg ctttatgagc cctgtactca ggatattgtg atgttccttg 3060

ttgtgatgtt gtgcaaccag aactacatcc gaaacccata tttggtggcc aaactggtag 3120

aagtcatgtt tatgaccaac cctgctgttc agccacgaac ccagaagttt tttgaaatga 3180

ttgagaacca tcctctctcc accaagttgt tggtaccttc cctgatgaag ttttatacag 3240

atgttgagca taccggagcc accagtgagt tttatgacaa gttcacaatt cgctatcata 3300

ttagcaccat ttttaaaagc ctttggcaaa acatagctca ccatggcacc tttatggagg 3360

agttcaactc cgggaagcag tttgttcgct atataaacat gttgataaac gacacgacgt 3420

ttttgctcga tgaaagtctg gagtctctga agcgaatcca tgaagtgcag gaagagatga 3480

agaacaaaga acagtgggac cagttgcccc gggatcagca gcaggctcgt cagtctcagc 3540

ttgctcagga tgagcgtgtg tcccgctctt acctcgccct ggccaccgaa accgtggaca 3600

tgttccacat cctcacgaag caggtccaga agcccttcct cagaccgctt ctcaacagtg 3660

aaatacagga gtactctgtg caaaagcaaa ttcttgaaaa gctaagtata tgttgaattt 3720

gtataaatcc agttattaca tttcatgaaa accttgtgac ttaaaggaat gctttcgtga 3780

ctccctttta tggccagtgt ttaatgctct ctaagccaca tcttcctgtt tcaggtttgc 3840

ttaaaaccat gtatgcccaa ccgtagtggg tactgagtca ccttgtgaga ttacagcata 3900

gattattact attttccagg tgtttcattt aagtttactc tgtctcattg actagattta 3960

aaactattca aggcataact tttatcttct ttccttgcat tactttgtta tttgtatctg 4020

ataagtacat aagaatgaca cagactgaac tgccaggggc ttttaacatt tatggggaaa 4080

aaagtttatg aaatactggc tggaagagct gactcaaaac tttttttgct cagataatgg 4140

taagatttgt ataattttct ctcttttact tgtttctcaa tgaatttgga gtgatacttt 4200

ttttaattaa aagcataaat gtaaagaaaa gtttggcttc ttttggtatt tataaataaa 4260

tatttcatca gcctgcaaca ttccattaag tattagaatt atcagatcag aaatggggag 4320

taaagttgaa atataatgtt gtctttcttc agcttatgat acacagcacc tgtaaggatt 4380

ctttgaagat taatccaacc aattcctgtt cctccactga aatgggagtt tttggtcctt 4440

ttcacttgtc tcaacagcat gaattgtcct attatcctgt gatttcctag gagcttggac 4500

cccgattggc tgcaatgctg aactttaatc ttcagcaact ttgtggcccc aagtgccgtg 4560

acctgaaagt tgaaaaccct gagaaatacg gctttgaacc aaagaagctg ttggaccaac 4620

tgacggatat ttacttacag ctggactgtg ctcggttcgc gaaagccatt gctgacgacc 4680

agagatccta cagtaaggaa ttgtttgaag aagttatttc aaagatgcgg aaggcaggga 4740

tcaaatccac aatagcaata gaaaaattta agctgctcgc cgagaaagtg gaggagatag 4800

tggccaagaa cgcacgcgca gaaatcgact acagcgacgc tcctgatgag ttcagagacc 4860

ctctgatgga caccctcatg acagaccccg tgcggctgcc ctctggcacc atcatggacc 4920

gctccatcat cctgcggcac ctgctcaact cccccacgga ccccttcaac cggcagacgc 4980

tgacagagag catgctggaa ccagtgccag aactgaaaga gcagattcag gcgtggatga 5040

gagagaaaca gaacagcgat cactaaaccg ttccgccgcc caccctctgc tagacacagc 5100

caaggccaac gaggcaagca gaagcagcgg cccgcagcga agctgccgtt catgtgttgg 5160

aggccaaatg tggcaaacca accccaggcc cacccagagc gagcaaacgc tgagacctga 5220

aaggacatgg atgagaagag gagcccgctt cctgtacata tatttaagtg acaaacacgg 5280

tcaaaagctt aagggacagg ttttatggtt gcttgtgtaa taaagcatgt ccttcgtatg 5340

tcacagtttg gggcaacgga agtcttttag tgatggctaa tgggtctggg cagcatccct 5400

tcatgaattt ttttttaatc caatatccgt tgatttgatt gtgattagag aaccttggac 5460

attttgctgc taaagaatct tttttcccct ctcccccttc ctgaccctac ttgcactgct 5520

gtggattttt ttaagagaag caaaaacaaa agtaaactcc tttccctggc cctccaaaca 5580

tatattctgt gagataactg tgcctgctac caagtgttaa tcctgggatc gtatttttat 5640

atcatattca catatttgtt tttttaattg gtgttagatg acatgattaa taaaaaaggc 5700

aagatatttt cagaatttga atttcagttt ttttttttct tttgaaatgt ccctttaaga 5760

tttttttatt ctaaacaaaa taaagaaaat cctgctgctc tggtccttgt gataagcctc 5820

tcttcggcat ctgaggagca gctgcagcaa aatctagggg tgtaagtgta tcaggactta 5880

tgtgacttat attttgggga gatgagggtt gggttttttt tttaatgcta cgtgacagtt 5940

tgaaaccttc acagttatcc tctgggggta aatcaattct tcaacccttg ggtgtgtgag 6000

tttgaggcag ggtcatttgt gtgatgtgtt tggccttacc aaagcaaaag agggtgcaag 6060

aatgtgggag tatgtctgcc ggtttcaaca cacacagaca aacacagcca cacgcgcaca 6120

caagtataag actttttgta ttactgctcc ctacttaaca tacttgaatt ctcaaatttc 6180

ctttggggta aaaaaaaaaa aaggatttga aaccataaag tgttctgaag aaattaagtc 6240

tataaaaagc atactttctt ttttcttttc cttttttccc tccacagaca atgtcctctg 6300

ttcaattcct aacgcaaact acaataaatg gtgacacacg ttcagaaga 6349

115

ggagctgcca gcggggaggc tgcagccgcg ggttgttaca gctgctggag cagcagcggg 60

cccccgctcc cgggaaccgt ttcccgggcc gttgatcttc ggccccacac gaacagcaga 120

gaggggcagc aggatgaatg tgggcacagc gcacagcgag gtgaacccca acacgcgggt 180

gatgaacagc cgtggcatct ggctctccta cgtgctggcc atcggtctcc tccacatcgt 240

gctgctgagc atcccgtttg tgagtgtccc tgtcgtctgg accctcacca acctcattca 300

caacatgggc atgtatatct tcctgcacac ggtgaagggg acaccctttg agaccccgga 360

ccagggcaag gcgaggctgc taacccactg ggagcagatg gattatgggg tccagttcac 420

ggcctctcgg aagttcttga ccatcacacc catcgtgctg tacttcctca ccagcttcta 480

cactaagtac gaccagatcc attttgtgct caacaccgtg tccctgatga gcgtgcttat 540

ccccaagctg ccccagctcc acggagtccg gatttttgga atcaataagt actgagagtg 600

cagccccttc ccctgcccag ggtggcaggg gaggggtagg gtaaaaggca tgtgctgcaa 660

cactgaagac agaaagaaga agcctctgga cactgccaga gatgggggtt gagcctctgg 720

cctaatttcc cccctcgctt cccccagtag ccaacttgga gtagcttgta gtggggttgg 780

ggtaggcccc ctgggctctg accttttctg aattttttga tcttttcctt ttgctttttg 840

aatagagact ccatggagtt ggtcatggaa tgggctgggc tcctgggctg aacatggacc 900

acgcagttgc gacaggaggc caggggaaaa acccctgctc acttgtttgc cctcaggcag 960

ccaaagcact ttaacccctg catagggagc agagggcggt acggcttctg gattgtttca 1020

ctgtgattcc taggtttttt cgatgccacg cagtgtgtgc ttttgtgtat ggaagcaagt 1080

gtgggatggg tctttgcctt tctgggtagg gagctgtcta atccaagtcc caggcttttg 1140

gcagcttctc tgcaacccac cgtgggtcct ggttgggagt ggggagggtc aggttgggga 1200

aagatggggt agagtgtaga tggcttggtt ccagaggtga gggggccagg gctgctgcca 1260

tcctggcctg gtggaggttg gggagctgta ggagagctag tgagtcgaga cttagaagaa 1320

tggggccaca tagcagcaga ggactggtgt aagggaggga ggggtaggga cagaagctag 1380

acccaatctc ctttgggatg tgggcaggga gggaagcagg cttggagggt taatttaccc 1440

acagaatgtg atagtaatag gggagggagg ctgctgtggg tttaactcct gggttggctg 1500

ttgggtagac aggtggggaa aaggcccgtg agtcattgta agcacaggtc caacttggcc 1560

ctgactcctg cgggggtatg gggaagctgt gacagaaacg atgggtgctg tggtcctctg 1620

caggccctca ccccttaact tcctcataca gactggcact gggcagggcc tctcatgtgg 1680

cagccacatg tggcgttgtg aggccacccc atgtggggtc tgtggtgaga gtcctgtagg 1740

atccctgctc aagcagcaca gaggaagggg caagacgtgg cctgtaggca ctgtctcagc 1800

ctgcagagaa gaaagtgagg ccgggagcct gagcctgggc tggagccttc tcccctcccc 1860

agttggacta ggggcagtgt taattttgaa aaggtgtggg tccctgtgtc ctcttccagg 1920

ggtccaaggg aacaggagag gtcactgggc ctgttttctc cctcctgacc ctgcatctcc 1980

caccccgtgt atcataggga actttcacct taaaatcttt ctaagcaaag tgtgaatagg 2040

atttttactc cctttgtaca gtattctgag aaacgcaaat aaaagggcaa catgtttctg 2100

tttccctgtg tctggccttc gcttcctgga aggctgangg gagggggcag gggtgtgggc 2160

agcggctccc gctgaggtgc tggtggggca tcagtgcagc tctgacggtg gcaggagggg 2220

cgctgggact gctgggcttt ctgctggctt cagcagggaa atcccccaag ggggctgtga 2280

gggaactggc ggcggcacgg tagtcagaga gcaaaattct ctgtgctttt gcctggctgt 2340

tctccgacag tcttgcgcct tggccccaga ggctggggtg acctgtgcca tggccaagga 2400

aggggaca 2408

116

tctactccag agctccgact tatttccaaa tattatgatc ctgcatgttt gctatttcac 60

aatcaatgac attttgaggc cacattgact ataaataatc acatctgtct ttggaaaagc 120

cacattttgt ttcacactaa ttcttttttt tgtccttgca aagttggctt tctggatgga 180

gagaatgatg tgtctggcaa tagggatctg tacatttcct atttcaagag cacacaaagt 240

attgacatct gaaatgaaaa cacaaaagga aaagcttaaa cttgccacat aggaagttct 300

tcatgcttga atagtgtctt cataaccata atgggatttt ttaggattat aatagttctt 360

tttaaatgct ttatttactt aacaaatagt aatcaaatca ttgcaaattc ttatatggaa 420

gatttaggcg ctggcagcaa tagttacata aattataatg tcaactatga caaactttcc 480

tatgtgtcta gagctagaat ataaaataga agtgtgccat catggctaca aatggttaag 540

aatatagatt cta 553

117

gagccctggg ccaaaatggc ggcctacctg cagtggcggc gcttcgtttt cttcgacaag 60

gagctggtga aggagccgct gaggcaatga tggggccgct cccggggcca cacctgcttc 120

tggatccgct gcttccaagt tcctttgcct ccctcctggc atcactgtct gcgactcagg 180

ccgagggagc ctggtctttg gagatatgga aggccagatc tggttcttgc cacgttccct 240

acagcttaca ggcttccaag cctacaaact acgggtgaca cacctgtacc aactgaagca 300

gcacaatatt ctggcatctg ttggagaaga tgaagagggc atcaacccct tggttaagat 360

ctggaacctg gagaagagag atggtggcaa tccactctgc actcgaatct tccctgctat 420

tccaggaaca gagccaactg ttgtatcttg tttgactgtc catgaaaatc tcaactttat 480

ggccattggt ttcacagatg ggagtgttac attgaacaaa ggagacatca cccgggaccg 540

gcatagcaag acccagattt tgcacaaggg caactatcct gtaactggat tggcctttcg 600

ccaagcagga aagaccactc acttgtttgt tgtgacaaca gagaacgtcc agtcctatat 660

agtttctgga aaagactacc ctcgcgtgga gttggacacc catggttgtg gcctgcgctg 720

ctcagcccta agtgaccctt ctcaggacct gcagttcatt gtggccgggg atgagtgtgt 780

ctacttgtac cagcctgatg aacgtgggcc ctgcttcgcc tttganggcc ataagctcat 840

tgcccactgg tttagaggct accttatcat tgtctcccgt gaccggaagg tttctcccaa 900

gtcagagttt accagcaggg attcacagag ctccgacaag cagattctaa acatctatga 960

cctgtgcaac aagttcatag cctatagcac cgtctttgag gatgtagtgg atgtgcttgc 1020

tgagtggggc tccctgtacg tgctgacgcg ggatgggcgg gtccacgcac tgcaggagaa 1080

ggacacacag accaaactgg agatgctgtt taagaagaac ctatttgaga tggcgattaa 1140

ccttgccaag agccagcatc tggacagtga tgggctggcc cagattttca tgcagtatgg 1200

agaccatctc tacagcaagg gcaaccacga tggggctgtc cagcaatata tccgaaccat 1260

tggaaagttg gagccatcct acgtgatccg caagtttctg gatgcccagc gcattcacaa 1320

cctgactgcc tacctgcaga ccctgcaccg acaatccctg gccaatgccg accataccac 1380

cctgctcctc aactgctata ccaagctcaa ggacagctcg aagctggagg agttcatcaa 1440

gaaaaagagt gagagtgaag tccactttga tgtggagaca gccatcaagg tcctccggca 1500

ggctggctac tactcccatg ccctgtatct ggcggagaac catgcacatc atgagtggta 1560

cctgaagatc cagctagaag acattaagaa ttatcaggaa gcccttcgat acatcggcaa 1620

gctgcctttt gagcaggcag agagcaacat gaagcgctac ggcaagatcc tcatgcacca 1680

cataccagag cagacaactc agttgctgaa gggactttgt actgattatc ggcccagcct 1740

cgaaggccgc agcgataggg aggccccagg ctggcagggc caactctgag gagttcatcc 1800

ccatctttgc caataacccg cgagagctga aagccttcct agagcacatg agtgaagtgc 1860

agccagactc accccagggg atctacgaca cactccttga gctggcgact gcagaactgg 1920

gcccacgaga aggatccaca ggtcaaagag aagcttcacg cagaggccat ttccctgctg 1980

aagagtggtc gcttctgcga cgtctttgac aaggccctgg tcctgtgcca gatgcacgac 2040

ttccaggatg gtgtccttta cctttatgag caggggaagc tgttccagca gatcatgcac 2100

taccacatgc agcacgagca gtaccggcag gtcatcagcg tgtgtgagcg ccatggggag 2160

caggacccct ccttgtggga gcaggccctc agctacttcg ctcgcaagga ggaggactgc 2220

aaggagtatg tggcagctgt cctcaagcat atcgagaaca agaacctcat gccacctctt 2280

ctagtggtgc agaccctggc ccacaactcc acagccacac tctccgtcat cagggactac 2340

ctggtccaaa aactacagaa acagagccag cagattgcac aggatgagct gcgggtgcgg 2400

cggtaccgag aggagaccac ccgtatccgc caggagatcc aagagctcaa ggccagtcct 2460

aagattttcc aaaagaccaa gtgcagcatc tgtaacagtg ccttggagtt gccctcagtc 2520

cacttcctgt gtggccactc cttccaccaa cactgctttg agagttactc ggaaagtgat 2580

gctgactgcc ccacctgcct ccctgaaaac cggaaggtca tggatatgat ccgggcccag 2640

gaacagaaac gagatctcca tgatcaattc cagcatcagc tcaagtgctc caatgacagc 2700

ttttctgtga ttgctgacta ctttggcaga ggtgttttca acaaattgac tctgctgacc 2760

gaccctccca cagccagact gacctccagc ctggaggctg gggctgcaac gcgacctact 2820

catgcactcc aggaggggca cttaagcagc ctggaggaag atgtgggcaa cagtggagga 2880

ccgagagaac agacacaatg ggacctgggc gggcgttaca cagaaggctg gctgacatgc 2940

ccagggctcc actctcatct aatgtcacag ccctcagaac taaagcggac tttctttccc 3000

tgccttctta tttagtcagc ttgccatccc tcctcttcac tagcagtgta gatcattcca 3060

gatcagtggg ggagggcacc tcagcaacct ctgagtgtgg acaatagctg ctttcttctc 3120

tatccaagag caccaggctg tgcttgggtc cttgctctca gagtctataa ataaaagaat 3180

ataatgattt g 3191

118

agcctccatt tttctccaga tggttgaaat aaccagcctc tgaaggagcc caatggtttg 60

gtcactgctc tctcagcaaa ttacagtcac tgtcacttag catggagagt ggacgttgca 120

catcactgtg aaaccttgca gaggaggaga gggcaggttc atcagaagaa agaaaggaca 180

aaatgactcc ttatgaagca ttttgtgcct tctgtgagaa aacatgtatt tagatcagat 240

aaactctagt caaaatacaa aaaggaaaaa tgaaagacct ctgaaatagg aacaatctct 300

tgaagaggca aatgactcaa aactgctcag tggctctttc agaaaatcta agtaaagttc 360

cctgacaaca gaaactgaag agattgcctg gttcatcttg tagtcttcca aaacagcaga 420

taatttctga atctcagatg ttgaatcagt gcaacgggat ggatttcttg ttcctaagtg 480

ttaaatgatc acatacataa aagagtctga gcctgagcaa 520

119

gttccgtgga ctccgctggc cccaggcctg aagttgagga ggaaaatggg gaggaagttt 60

tcctgagtgc ctatgatgac ctaagtcccc ttctgggacc taaaccccca atctggaagg 120

gttcagggag tctggaggga gaggcagcag gatgtggaag gcaggctctg ggacagggtg 180

gggaagagca ggcatgctgg gaagttgggg aggacaagca ggctgagcct ggaggcaggc 240

tagacatcag ggaagaggca gagggaagtc cagagaccaa ggtggaggct ggaaaggcca 300

gtgaggatag aggggaggct gggggaagcc aagagacaaa agtcagattg agagaaggga 360

gtagggaaga gacagaggcc aaggaagaga agtccaaagg tcagaagaag gctgacagta 420

tggaggctaa aggtgtggag gaaccaggag gagatgagta tacagatgag aaggaaaaag 480

aaattgagag agaagaggat gaacaaagag aggaagccca ggtagaagct ggaagggacc 540

tagagcaagg ggcccaggaa gatcaagttg ctgaggagaa atgggaagtt gtacagaaac 600

aagaggctga gggagtcaga gaggatgagg acaaaggaca gagggagaag gggtaccatg 660

aagcaagaaa agaccaagga gatggtgaag acagcagaag cccagaagca gcaactgaag 720

gaggagcagg ggaggtcagc aaggaacggg agagtgggga tggagaggct gagggagacc 780

agagggctgg agggtactat ttagaagagg acaccctctc tgaaggttca ggtgtagcgt 840

ccctggaggt tgactgtgcc aaagagggca atcctcactc ttctgagatg gaagaggtag 900

ccccacagcc acctcagcca gaggagatgg agcctgaggg gcagcccagt ccagacggct 960

gtctatgccc ctgttctctt ggcctgggtg gcgtgggcat gcgtctagct tccactctgg 1020

ttcaggtcca acaggtccgc tctgtgcctg tggtgccccc caagccacag tttgccaaga 1080

tgcccagtgc aatgtgtagc aagattcatg tggcacctgc aaatccatgc ccgagggcct 1140

ggccggcttg atgggactcc tggagaaagg gcttgggggt cccgagcttc tcgatcctct 1200

tggaggaatg ggggtagtct ttcctttgat gctgctgtgg ccctagcccg ggaccgccaa 1260

aggactgagg ctcaaggagt tcggcgaacc cagacctgta ctgagggtgg ggattactgc 1320

ctcatcccca gaacctcccc ttgtagcatg atctctgccc attctcctcg gccccttagc 1380

tgcctggagc tcccatctga aggtgcagaa gggtctggat cccggagtcg tcttagtctg 1440

ccccccagag aaccccaggt tcctgacccc ctgttgtcct ctcagcgcag atcatatgca 1500

tttgaaacac aggctaaccc tgggaaaggt gaaggactgt gattaggacc acagccctgg 1560

gcaaagggga ccagcaagtt gtcttgaatc tccagggttc ctgactagct gtctcctctg 1620

cagcatgagc agctgtagtg cccaactcta taggctttgg ccctccagct tctctctttg 1680

actgtgggag gcactgcctt ggttggttta cctgaacttg tctccgacac aaagcactta 1740

tctcttagga gattcccaag aaagtcaaca agatcttgtt cccagggagt gggtcattgg 1800

ccaaagggaa cataaggtag gcagaaaact taaaagagtt tgttaaagtg aagactggag 1860

aaattcctcc cttcctctga gctgtgaatc tctcttcatg aaagccaaag gtagagacag 1920

ggaggacagg gccaggttag ggccttccac acacaaacac ttctagagtt gcccattcct 1980

gttatgttct tggaccctaa gatacctcct gtccctttta aatccagatt aagagaaacg 2040

tccaggaaga gctctttgaa gccctcaata tttgttggag ggactggact cctctccagc 2100

tccccaccct ctgcctccag tcaccatgtg caagagaggt cctgtacaga tctctctggg 2160

ctctcctttc tcctttggaa taacttgttc ctatttcagg aaagggaaat ggtgtcactc 2220

aggccctggg actgcttctc cagccaggct ggggccacag gtcccactct agtgaaggtc 2280

aatgtctcaa aataaaagct gtatttttac acataaaaaa aanaaaaaaa anctcgnggg 2340

ggg 2343

120

aaacgaggtc aagtagtaag agaagcggta agagtgacgg gaacaggagt cattgacctc 60

ttgggagagg agacattgga ggtggtgatg atttgctgaa gcagccacac acgttcagct 120

tgtgaggaca gcagttgtta ggcaggggat gagggaggaa gctggcagat ctgtgcaggt 180

gagaggtacc tgtggccttg ggctcatgga agtgggaggt gatgggattc taatgtgctt 240

gggtacagtt tacaaataca acctctctta gtttgcccaa tacctccaaa ttcctggggt 300

ggcacacctg aggttcaggt ggcatgactg agccacagtc acacatcccc actgtaggat 360

accaccacgg ttgggttagg ttccagcaca tgggcggtcg cggcctggcc ctcttggtcc 420

cacctcacct ggtgactagt gcagaccact ctgttcttgc ctgtttcagg cagcgcgagg 480

aggag 485

121

cgcgggcgcg tcgccctctg cccccgccgg caccctggcc atgacaggca agtcggtgaa 60

ggacgtggat cggtaccagg ctgtcctggc caacctgctg ctggaggagg ataacaagtt 120

ttgtgccgat tgccagtcta aagggccgcg atgggcctct tggaacattg gtgtgttcat 180

ctgcattcga tgtgctggaa tccacaggaa tctgggggtg cacatatcca gggtaaagtc 240

agttaacctc gaccagtgga ctcaagaaca gattcagtgc atgcaagaga tgggaaatgg 300

aaaggcaaac cgactttatg aagcctatct tcctgagacc tttcggcgac ctcagataga 360

cccagctgtt gaaggattta ttcgagacaa atatgagaag aagaaataca tggaccgaag 420

tctggacatc aatgccttta ggaaagaaaa agatgacaag tggaaaagag ggagcgaacc 480

agttccagaa aaaaaattgg aacctgttgt ttttgagaag gtgaaaatgc cacagaaaaa 540

agaagaccca cagctacctc ggaaaagctc cccgaaatcc acagcgcctg tcatggattt 600

gttgggcctt gatgctcctg tggcctgctc cattgcaaat agtaagacca gcaataccct 660

agagaaggat ttagatctgt tggcctctgt tccatcccct tcttcttcgg gttccagaaa 720

ggttgtaggt tccatgccaa ctgcagggag tgccggctct gttcctgaaa atctgaacct 780

gtttccggag ccagggagca aatcagaaga aataggcaag aaacagctct ctaaagactc 840

cattctttca ctgtatggat cccagacgcc tcaaatgcct actcaagcaa tgttcatggc 900

tcccgctcag atggcatatc ccacagccta ccccagcttc cccggggtta cacctcctaa 960

cagcataatg gggagcatga tgcctccacc agtaggcatg gttgctcagc caggagcttc 1020

tgggatggtt gcccccatgg ccatgcctgc aggctatatg ggtggcatgc aggcatcaat 1080

gatgggtgtg ccgaatggaa tgatgaccac ccagcaggct ggctacatgg caggcatggc 1140

agctatgccc cagactgtgt atggggtcca gccagctcag cagctgcaat ggaaccttac 1200

tcagatgacc cagcagatgg ctgggatgaa cttctatgga gccaatggca tgatgaacta 1260

tggacagtca atgagtggcg gaaatggaca ggcagcaaat cagactctca gtcctcagat 1320

gtggaaataa aaacaaaaca cctgtatggc tgccattctc ttcagccctc gctctacccc 1380

tttccacagc ctcaacccct gacccatcct cttttcctac ctctctgttt ggtttagaaa 1440

ttgctca 1447

122

gaggacccat tcatgccaga aagctggtaa ctccctccca gcatccctgc ggaaggagtc 60

agtttctgag agtgtgactt ttcaaggcga atgatgggga agggttcccc agtccccaca 120

gtggccccac ctctgggccc tgcaccagag cccttctgtg tcacggcggg ctgtgcaccc 180

atgcacacac ctacgcacac acaacactcc gcactgcagt atattcttgc caaagatttc 240

ctttaaaagc aagcactttt actaattatt attttgtaaa tgtttatctt cttctgtctt 300

ctccctccct gaatctattt tactgttgtt tattgttgaa tctgtgtgtc agccaggaga 360

gcgctgtctg gccttgaaca tgggctggga tgggaaaggg tctgggagaa gatgggcaac 420

aaagagccag ggagtcatgg acatcgcagc gacgcagacc ccagcaggtt cagtcccgtg 480

ctgccaccag ctgtccagct gggtgtctgg agggaagagg gcagaggagg gtcatgtccc 540

ttcagctggg ggaggggccc agtgagctcc acgtggcttt ttcccaaagg gagcaagagg 600

gaaggattgg gcgagaaaac aatggagagg ggacctgcga aggaaaacag ggaggaagtg 660

agcggtttga tcagcctgct atcacggtgt tctggctctc ttatttagcc aggcgcttaa 720

gggacagata catcacatcc taagtttggg aaaggccttt gacccatgtc atctgagcgt 780

ctcctccagt agctctgaaa gctgtggaca ccaatggcca ggattccttc tcccctggtt 840

tttgaggatc cctgggtctt ctgagactgg ccaggagagg gatggtgggg ccagtggttg 900

tgtgaaagca ggaggggcag ccctcctgga caagtgtgat ccccctataa acggctctca 960

ggaggttagt gagtaggaga ttctgccttg ttctgatgag cctgtgcagg ggctccaggg 1020

gagcatgctg tccagggggc acagaagggt ggtgagtgtg atcaaatcta gtctcactcc 1080

cactttttta gtctcactcc tacttttgtc caccacccct gcctcctgga tcttctccca 1140

cttttttttt cagctttagg acctggggag atcctgtgag tcaaggcaga cacccaatcc 1200

tgcccccaca ctcggggtcc tccaagaggt tggggggcag agtcccagag cagcccttta 1260

ccccaggtcc aggccctgga atcctgagac tcgcgtttcc ttggccagtg gtaacacagg 1320

acgtgtgtgc gcatgtgcaa gtgtggatgt atgtgtgtgc gtgtgttttg ctcatttctt 1380

tagggaactt gggagtcggg gttggaggtg ctgggcaatg gaacttcaaa ttcaatgtcg 1440

cccagcagtg aggggagtcg ggaggtgagg cctgtaggcc aaccaattgg tggagtctca 1500

gcgatagccc aggtgagaag tggttcaccc agaggggcag ggtgggggcc tcgggcagat 1560

ctgtccctct tggcccctct gtcctcaaat gtccaaaatg ttggaggacc tctgttcata 1620

tcccacgcct gggctcttgc cagcagtgga gttactgtag agggatgtcc caagcttgtt 1680

ttccaatcag tgttaagctg tttgaaactc tcctgtgtct gtgttttgtt tgtgcgtgtg 1740

tgtgagagca catcagtgtg tgcaggctgt gtttccccat ttctctcctc ccttcagacc 1800

catcattgag aacaaatgta agaaatccct tcccaccacc ctccctgcct cccaggccct 1860

ctgcggggga aacaagatca cccagcatcc ttccccaccc cagctgtgta tttatataga 1920

tggaaatata ctttatattt tgtatcatcg tgcctatagc cgctgccacc gtgtataaat 1980

cctggtgtat gctccttatc ctggacatga atgtattgta cactgacgcg tccccactcc 2040

tgtacagctg ctttgtttct ttgcaatgca ttgtatggct ttataaatga taaagttaaa 2100

gaaaaaaaaa aaaaaa 2116

123

ttcggcacag cacggaaccc cctcctctca cagaaccccc tcctctcaca cagaaccccc 60

tcctctcaca cagaaccccc tcctctcacg gaaccccctc ctctcacgga accccctcct 120

ctcacggaac gccctcctct cacacagaac cccctcctct caccgaatcc catctcagtc 180

ttgagttttc cctcgactct gttgcttccg ctcacatctt agtgagtccc cagggcctct 240

gcggggcatg gaatcacacg tgcagtgttc cggcatgttc agcctggtgt gtgacagtgg 300

ggttccctgc caggccagca gtgtgctctg actcggggca gggaccaggt tctgtgtagc 360

tttgtgctca agtgctgagc agagtagact ctcagcagat gtttgaatga atgggtgaac 420

caatggctgc acaaatgaac gagcctgact ctccctcatg atttggtcca tagtgtgttt 480

aaataccctc ctagtgggct tttagctcct tgaagatgga aacaggtttg catagtaagt 540

ttgttttatt gaatggaatg gacttaaagt cttcggactt gggagaatta ggacagatct 600

gtttccccgt tggtaaagta aaggttgggc ctgatgatct cagaaactca ggaagagtga 660

tggtcggccc cagggtcgag agtgagttac tgccaggtcc agggctgtcc ctgtgttctg 720

gctcccagac cacagtgttt cttcctgaag ccggtggttg cagccacttt gccttgctcc 780

tctacgcctt tcctgaagga tgaggtgggg ccagtctgcc tctgggagct cggtcaagtt 840

cacccgcctg cctgcctgtc cagccaagta cctggcccag atcattgtga tgggcgtgca 900

ggtggtgggc agggcctttg cacgggcctt gcggcaggag tttgcagggg tgagccacca 960

actcggaagg cccagggtga agtgtgggct gctgaggact gagcgatcac ccacatgtcc 1020

acacagccag ccgggccgca gctgatgccc gaggacgcgc tggacaccgg tctgcagccg 1080

cttccaacct ctccggcctc agcctccagg aggcacagca gattctcaac gtgtccaagc 1140

tgagccctga ggaggtccag aagaactatg aacacttatt taaggtgaat gataaatccg 1200

tgggtggctc cttctacctg cagtcaaagg tggtccgcgc aaaggagcgc ctggatgagg 1260

aactcaaaat ccaggcccag gaggacagag aaaaagggca gatgccccat acgtgactgc 1320

tcggctcccc ccgcccaccc cgccgcctct aatttatagc ttggtaataa atttcttttc 1380

tgcaaa 1386

124

ttttagccct tgttgtttat ttttcaataa acaaggtttt tttgcatgtc tggactggta 60

gtaaacggga aagctaaaaa gagcgccaag gacatttttt ttaacatttt ggtgacaaaa 120

ttgatactcc tcttcctcct ctcctaattt gggaccaaat tgctgatcat gtcttggatc 180

gctgtctttg agcttttccg tttgtttcgt aaactacaca ctacaccaga cacacacaag 240

gtgcggctgg gcagtcaagg atcccgacac tctcagcaga atctggtggc catagaacat 300

ggaatgacca tttctgcatg acgtgaagac cgtggcgagg ctgctgacac tgcttctgtt 360

gcacgggggg ggtagtgcga gtggtgggca ctgtggaatt tgggagggac ggcctcatcg 420

ggtgctggta atagataatt tgttgcgtgg gaaggtgaga tggtggctct tctccaaggg 480

aggcgtctgc tcaagaccct ccactcccac ggcatgtgac cggcaccgcg ctgggctccc 540

tggggacagc tgtgtgtcca cccccttcca gactgccccc tcgtcctgcc tgccctgcng 600

cttccgcaca ctgcctagtn tccgcaggtg cctggaaatg cttcctgatc agatgggttg 660

tggacggtga acaaatgaat ggatggggag ttggtcaagg atacctcgac cgtgggacgt 720

ctttttcttg ttatcagggg aacatggctg ttctctatag catcaagatc gaaaacatag 780

ataatttgat catctgacca atcttagaat tttctatttg gggaaactga ggaacagaat 840

cgttagcagg ctcagtccag gtctcacgct gagagaggcc aggcagggta ccagacgccc 900

gcctgacaca tgccaacaat tctttttttt gtcttttt 938

125

gtttttaggg naggaaaagt gtgnggctgc tgatctgagc tctctggcca ggagnaggga 60

agggggtggg ggtggagagg ngggaggagg gggtaanaag gggaggngat gcgaggaggg 120

agtggagaga gggcaggtaa ttcggaggag ggaagaggca gccccctgcc cggccagctc 180

gtgactaatt taggcaaaag gcagcctgga gctatttcca ttcggcggcg ggaacaggtg 240

ccggcgcctc cgccccatcc ccaggggccg cctcccccgg ggcggcctcc aggctgccga 300

gacctataaa ggcgccaggt tttctcaatg aagccgggac gcactccgga gcgcactgcg 360

tggtcgcacc ctacccgggc tgccttggaa gtcgtccccg ccgcccctcc gcaccggcat 420

gaagctcatc gtgggcatcg gaggcatgac caacggcggc aagaccacgc tgaccaacag 480

cctgctcaga gccctgccca actgctgcgt gatccatcag gatgacttct tcaaggctcc 540

tctgtttcag ccccaagacc aaatagcagt tggggaagac ggcttcaaac agtgggacgt 600

gctggagtct ctggacatgg aggccatgct ggacaccgtg caggcctggc tgagcagccc 660

gcagaagttt gcccgtgccc acggggtcag cgtccagcca gaggcctcgg acacccacat 720

cctcctcctg gaaggcttcc tgctctacag ctacaagccc ctggtggact tgtacagccg 780

ccggtacttc ctgaccgtcc cgtatgaaga gtgcaagtgg aggagaagta cccgcaacta 840

cacagtccct gatccccccg gcctcttcga tggccacgtg tggcccatgt accagaagta 900

taggcaggag atggaggcca acggtgtgga agtggtctac ctggacggca tgaagtcccg 960

agaggagctc ttccgtgaag tcctggaaga cattcagaac tcgctgctga accgctccca 1020

ggaatcagcc ccctccccgg ctcgcccagc caggacacag ggacccggac gcggatgcgg 1080

ccacagaacg gccaggcctg cagcgtccca gcaggacagc atgtgagcgt ttccctatgg 1140

gggtgtctgt acgtaggaga gtggaggccc cactcccagt tgggcgtccc ggagctcagg 1200

gactgagccc caagacgcct ctgtaacctc gctgcagctt cagtagtaaa ctgggtcctg 1260

tttttttata aangcaaaag tacttaa 1287

126

tgccttaaag aaaataataa gagaagggtg tgttctcttc caagtaatga gccgatcaag 60

gggaagcaac ccaaggctag caggctcttt tcaattccca gctctgccac tcttagcatg 120

gcagagagtt ggcctcatta tgccagtatg gctgccacag tgtcagacat cacattccag 180

gcagtggaaa ggagaaagaa ccaaagggca tccctttctc ttgaagcagt ccctgtgagg 240

ggggattatc tggaagcccc aacccaattt ctgcttccaa ccattatcca tagaaacaac 300

tggaagttga gaagtgcagt cttttaggtg ggcacctggc tgccctgtat gaaaccagaa 360

ttaggttggt cagcaggaaa acaagaaaac acttactgtg ttgactgagg tttttgacgc 420

atcgctttat tgtcaaatta aacaactcta tctcattctg cactgaaaca cgtactacca 480

ttgcctataa ttggaaaatg atcctcagag gcacagaaga tgccctgatg gaaagtttgc 540

cccttgggca aagagacagc catgggaacc ttcagacata gagagagaag gtggcttttc 600

tccctacatt cctcaaatag ctaagatttg gccagtgtgt tttctaagtc aattctagtg 660

tgtttcatcc tcacctcttc cctctgtggc tttgatgatg gaagtgtagt cctaacctac 720

tgcacagctg ggaccccctg cccctagatc ccaatactgg ggatgggagg accttgcact 780

attcccctca gtccatctat cgaggtcttt gcaggaagca tactgggaat tgaaacgaga 840

gcctaaatga catctaagaa aggcagtgtt caataccagg tattaggtga ggatgggatt 900

ctaaggacat cagtgggagg cagggagcca ccttcagacc tcagcatgga agcttccaag 960

atccagagga agaggcaaca gcactgagag tcataggtag aagaatcatc acagccctgc 1020

taaccaggca gctgatgccc ctctcccctg gctccctgtg tccaaatcct acaggggcat 1080

ctgttggctg aactcaacct gaagccaaag agaagatgag tggagagagg caacatttat 1140

agagctcagg tttctagggc tggagaggga tctggaggga cacacaggag acacctggca 1200

taaccaaaaa atgattaana aaaaaaaaaa aanaaacatc tatggagcat gggacacggg 1260

gagtggaggc agctaaaagc catctcatct ttcaccgtat tcaacaagcc cattataaca 1320

agtctttcac gctcaaccat tcaaacaatc ccaacaatcc cagcctaaga atttcctggc 1380

atttgatgaa aatggctgtg ggttttgcta tctttaagct ccctggggaa gcaggatata 1440

agcccagggg ctggcaggct ctttctagct acctgctctt gcacatagag tttgcctcat 1500

ggttgcaaga aggctgccat agctccagat ggcacataga cattccaggc agcaggaaaa 1560

aggaaggagc acttaaccga aggaggtcag ggagttggtt agtctccacc tgaagaagag 1620

agccatgaac cagcttcagt tgactaacgg gctcctgtga gtgcatcttt ggacttttct 1680

ggaggttgaa atctagatgt ggtatgtgtc ttaaagcagc caccaactcc tcccattacc 1740

ttccaagtga gcccaactac acgatggagc ctcttccctg cccttggatc tgggctgagc 1800

ctctgacttg cgttgaccaa cagaatgcag tgaaagtgat gccgatacta ccctccctgc 1860

cctagacttg ggatacctgg cagctatatt cttccattcc tcaggacttg caaaaacggg 1920

tctcagcatg ccttcccaga gccatgaggt gtttctttgc ccattcattg atctgagaag 1980

tgagtgtaag gagtttaaat caacctctgt tctgtgctag ttaaggtaat aaagttgctg 2040

cagtccaggg ggtaggtacc tgtggacggc tctgcgaata ggacagttgc atttcttggg 2100

aatcaagtgc atccctaggc tggcagtgca gcagaaatac tgaataaaat gtgacaaatc 2160

tccctgaaaa aa 2172

127

ctcgagccgg ggtgcggcag cactggccag gggaagaggg tgatccgacc cggggaaggt 60

cgctggggca gggcgagttg ggaaagcggc agcccccgcc gcccccgcag ccccttctcc 120

tcctttctcc cacgtcctat ctgcctctcg ctggaggcca ggccgtgcag catcgaagac 180

caggaggaac tggagcctca ttggccggcc cggggcgccg gcctcgggct taaataggag 240

ctccgggctc tggctgggac ccgaccgctg ccggccgcgc tcccgctgct cctgccgggt 300

gatggaaaac cccagcccgg ccgcacgccc tgggcaaggc cctcctgcgc tctcctgcct 360

ggccactctc ggcgccgccg gccagcctct tgggggagag tccatctgtt ccgccagagc 420

cccggccaaa tacagcatca ccttcacggg caagtggagc cagacggcct tccccaaggc 480

agtaccccct gttccgcccc cctgcgcagt ggtcttcgct gctgggggcc gcgcatagct 540

ccgactacag catgtggagg aagaaccagt acgtcagtaa cgggctgcgc gactttgcgg 600

agcgcggcga ggcctgggcg ctgatgaagg agatcgaggc ggcgggggag gcgctgcaga 660

gcgtgcacga ggtgttttcg gcgcccgccg tccccagcgg caccgggcag acgtcggcgg 720

agctggaggt gcagcgcagg cactcgctgg tctcgtttgt ggtgcgcatc gtgcccagcc 780

ccgactggtt cgtgggcgtg gacagcctgg acctgtgcga cggggaccgt tggcgggaac 840

aggcggcgct ggacctgtac ccctacgacg ccgggacgga cagcggcttc accttctcct 900

cccccaactt cgccaccatc ccgcaggaac acggtgaccg agataacgtc ctcctctccc 960

agccacccgg ccaactcctt ctactaccca cggctgaagg ccctgcctcc catcgccagg 1020

gtgacactgg tgcggctgcg acagagcccc cagggccttc atccctcccg ccccagtcct 1080

gcccagcagg gacaatgaga ttgtagacag cgcctcagtt ccagaaacgc cgctggactg 1140

cgaggtctcc ctgtggtcgt cctggggact gtgcggaggc cactgtggga ggctcgggac 1200

caagagcagg actcgctacg tccgggtcca gcccgccaac aacgggagcc cctgccccga 1260

gctcgaagaa gaggctgagt gcgtccctga taactgcgtc taagaccaga gccccgcagc 1320

ccctggggcc ccccggagcc atggggtgtc gggggctcct gtgcaggctc atgctgcagg 1380

cggccgaggg cacagggggt ttcgcgctgc tcctgaccgc ggtgaggccg cgccgaccat 1440

ctctgcactg aagggccctc tggtggccgg cacgggcatt gggaaacagc ctcctccttt 1500

cccaaccttg cttcttaggg ggcccccgtg tcccgtctgc tctcagcctc ctcctcctgc 1560

aggataaagt catccccaag gctccagcta ctctaaatta tgtctcctta taagttattg 1620

ctgctccagg agattgtcct tcatcgtcca ggggcctggc tcccacgtgg ttgcagatac 1680

ctcagacctg gtgctctagg ctgtgctgag cccactctcc cgagggcgca tccaagcggg 1740

ggccacttga gaagtgaata aatggggcgg tttcggaagc gtcagtgttt ccatgttatg 1800

gatctctctg cgtttgaata aagactatct ctgttgctca caaaaaaaaa anatananna 1860

aannnanana anccaaattn atcaaa 1886

128

cagccagncc ccgcgccgcc cgcnccccgc tcgactccgg aggctcccgc agccccggcg 60

tccgccccgc tggcccctcc cccgggggcc atgggggcgc ccccgggcta ccggccctca 120

gcttgggtgc atctcctcca ccagctgccc cgcgccgact tccagctccg cccggtgccc 180

agcgttttcg cgccccaaga gcaggaatac cagcaggcct tgttgctggt ggcggccttg 240

gcgggcctgg gcttgggcct gagcctcatt ttcatcgctg tctacctcat ccgcttctgc 300

tgctgccggc cccccgagcc ccccgggtcc aagatcccct cgcccggggg aggctgcgtc 360

acctggagct gcattgtcgc ccttctcgcc ggctgcactg gcattggcat cggtttctat 420

ggcaacagtg agaccagtga tggggtgtcc cagctcagct ctgcgctgct gcacgccaac 480

cacacactca gcaccattga ccacctggtg ttggagacgg tggagaggct gggcgaggcg 540

gtgaggacag agctgaccac cctggaggag gtgctcgagc cgcgcacgga gctggtggct 600

gccgcccgag gggctcgacg gcaggcggag gctgcggccc agcagctgca ggggctggcc 660

ttctggcagg gagtgcccct gagccccctg caggtggctg aaaatgtgtc ctttgtggag 720

gagtacaggt ggctggccta tgtcctcctg ctgctcctgg agctgctggt ctgcctcttc 780

accctcctgg gcctggcgaa gcagagcaag tggctggtga tcgtgatgac agtcatgagt 840

ctcctggttc tcgtcctgag ctggggctcc atgggcctgg aggcagccac ggccgtgggc 900

ctcagtgact tctgctccaa tccagaccct tatgttctga acctgaccca ggaggagaca 960

gggctcagct cagacatcct gagctattat ctcctctgca accgggccgt ctccaacccc 1020

ttccaacaga ggctgactct gtcccagcga gctctggcca acatccactc ccagctgctg 1080

ggcctggagc gagaagctgt gcctcagttc ccttcagcgc agaagcctct gctgtccttg 1140

gaggagactc tgaatgtgac agaaggaaat ttccaccagt tggtggcact gctacactgc 1200

cgcagcctgc acaaggacta tggtgcagcc ctgcggggcc tgtgcgaaga cgccctggga 1260

aggcctgctc ttcctgctac tcttctccct gctgtctgca ggagcgctgg ccactgccct 1320

ctgcagcctg ccccgagcct gggccctctt cccacccagt gacgactacg atgacacaga 1380

cgatgacgac cctttcaacc ctcaggaatc caagcgcttt gtgcagtggc agtcgtctat 1440

ctgagcccct cctcccggct ggactggagc ctggctcccc tcttcgttcc ttccctggct 1500

gccggaggag accccactaa cccagcctgc ctgggctctg accactaaca ctcttggcca 1560

tggacagcct gcacaggacc gcctccctgc tcttggccac tgtgctccca tttctgtcct 1620

tggccttggg agtagctgag ggggcagact agggagtagg gctggcaggg gagggggcag 1680

acagcctcgc ctcgcaccct tcatccctgg ctgccggtcc catccttgga gggactaagc 1740

tgggggtggg ggacatgagt ccccctgctg cccctgccac atcccagtgg gctctgaccc 1800

cctgatctca actcgtggca ctaacttgga aaagggttga tttaaaataa aagggaagac 1860

tattttacaa gcagctgggt cctccttatt tctcctctcc cttgattcgg cctcctggcc 1920

agggctggga catcctccct gctgtcctct ctcccccggc ctcccagctg ccaggaattt 1980

ctgcgcctgt ccaggctcag caaggggtcc aaagacat 2018

129

tatttttttc atgatatatg ccatattcca ctgtgtaatg tagattacac cacagggttt 60

ttaatttcct aaaggcaaga gctataacct agtcatcttc ctctcctaag tggggagtat 120

caccatgatt tgaccaagta gctatgatat gggtgctatc tccataaatg aatgagcagt 180

gaggaaaaag gagatgatta tgagtgaatg aagaatctta ataaggaaag tttattccac 240

agtgaagcag tgttggtggc tccaaaacct ctctttagga aggatttagg acagcatcct 300

aatcaaaagg gcctggaagc actttataaa agagagagac aagatcgcat gtcaaactag 360

aaggaaggag gtgagaggag atagggctcc agagtggagc aagccccttc tgtccccttg 420

aacttcctgc cggtgcatgg gttacctctc attaaattta atagtacttg ttgctttggt 480

gtagtgaaat gaatgccttg atgaaattgc attgcaccat ttttgaaaga gagaatactc 540

aaacgtgtca cttctgtttc ttgcaagcaa ctgtgatcct gagctgtgca cacttctggt 600

tgggattatt tctggtttct acttcctgtt tgaagatgtg gcatggagag tgctctgctt 660

tgacctgaag tattttatct atcctcagtc tcaggacact gttgatggaa ttaaggccaa 720

gcacatctgc aaaaaagaca ttgctggagg aggtgcaaag agctggaaac caagtctcca 780

gtcctgggaa aagcagtggt atggaaaagc aatggaaaga gcattttgaa aatgccattc 840

cactgttttc tggcctttat gatttctgct gagaaatcca ctgttagtct tgatggggtc 900

tccttcatag caccaatgac ctgaagagcc ttgttgaagg aagactccat ctgatgactc 960

agagcaagta ttttttagtg tgttattgtt attagcagaa agagggccat aaaatacatg 1020

gggcaagctg aatatatctt aggcaaaaga agaaaatatt caaattctta tgttatttta 1080

tctaattatt ttatctcttt ttgtgtgtga cttataatgt gtgtattgta ttaataaaag 1140

tatataaaca tgtagtttac 1160

130

caggcaccca ccgtcacacc cggctaattt ttttgtattt tagtagagac agggtttcac 60

cgtgttagcc aggatggtct tgatctcctg accttgtgat ccaccagcct cagcctccca 120

aagtgctggg attacaggcg tgagccactg tgcccggcca agaatttttt tatcgataac 180

atagtgagct ctctgcctct tcggaacgat gtccactttg cttatgatca acccaagcag 240

gactcttctc tccctggacg cctctcccct ggtctggaat cttccagttc tgccagaatt 300

ggcctttccc agatgctgca aacttccagt tgaacccctt tttctgtgtg gcccctgggg 360

ctgcgagacc aaaatccatg agttctgtgt accctagacc tttggaaggt gagagcaggg 420

ccctgagaaa aggcagccac ctcctctccc tggctgaacc cctgccaccc tactcctcac 480

cagaattgtc agtggccttt caccacagtg gtccttcctg cctgagccct gcactgtccc 540

agaccacaca gaagtctggt cacctctggg cgcctgggat ggtcaccgaa gagaagcacg 600

ctgtccccgt ctctcctggc ttctgccaga aaatcgaaca agtgcaatta acacactgtt 660

actgccgaag cctgaaactc ccaggacttg tccttgatcc ttccagaaac caccaggtcc 720

ggcacttgga gccccccgga gagggacctc ccagccgagc cctcaaagaa ctccatgaaa 780

tcaggaactg cttgatgaaa tgtatctcct tgtacctgga agatgaagcc caaacaccca 840

cacctctgtc tcccccaggg ctcgggatgt ctccagcagc ccggccacgc agcttcccag 900

gtgggctcgg ggaggtggga gcagggacca tctctgtccc ctccaccctc actccatcca 960

cctcggagac caccctcccc cagccagata cggaataaaa ctacagacgc agacgtcgga 1020

ataaaaaaaa aaaaaaa 1037

131

gaacattcct actcgagcct gggcctcaag gccaagatgg atgctggttg gacaggcctg 60

caagcctctg atataatgtg gaccatatca gacacaggtt ggatactgaa catcttgggc 120

tcacttttgg aatcttggac attaggagca tgcacatttg ttcatctctt gccaaagttt 180

gacccactgg ttattctaaa gacactctcc agttatccaa tcaagagtat gatgggtgcc 240

cctattgttt accggatgtt gctacagcag gatctttcca gttacaagtt cccccatcta 300

cagaactgcc tcgctggagg ggagtccctt cttccagaaa ctctggagaa ctggagggcc 360

cagacaggac tggacatccg agaattctat ggccagacag aaacgggatt aacttgcatg 420

gtttccaaga caatgaaaat caaaccagga tacatgggaa cggctgcttc ctgttatgat 480

gtacaggtta tagatgataa gggcaacgtc ctgccccccg gcacagaagg agacattggc 540

atcagggtca aacccatcag gcctataggc atcttctctg gctatgtgga aaatcccgac 600

aagacagcag ccaacattcg aggagacttt tggctccttg gagaccgggg aatcaaagat 660

gaagatgggt atttccagtt tatgggacgg gcagatgata tcattaactc cagcgggtac 720

cggattggac cctcggaggt agagaatgca ctgatgaagc accctgctgt ggttgagacg 780

gctgtgatca gcagcccaga ccccgtccga ggagaggtgg tgaaggcatt tgtgatactg 840

gcctcgcagt tcctatccca tgacccagaa cagctcacca aggagctgca gcagcatgtg 900

aagtcagtga cagccccata caagtaccca agaaagatag agtttgtctt gaacctgccc 960

aagactgtca cagggaaaat tcaacgaacc aaacttcgag acaaggagtg gaagatgtcc 1020

ggaaaagccc gtgcgcagtg aggcgtctag gagacattca tttggattcc cctcttcttt 1080

ctctttcttt tccctttggg cccttggcct tactatgatg atatgagatt ctttatgaaa 1140

gaacatgaat gtaaaaaaaa aaaaaaa 1167

132

cacacacata taatttgaaa gaggtgagta tgtactctga cttcagctct caggttttaa 60

aaattatatt agtgggacca gttatgacaa gaataatcat tatagtactt ttcagatttt 120

ataacctgga gcagattatt ttaagttgat tagtaggttc tgttacagtt tttcttttgt 180

tcgtgcactt atagtcttca tttaattcct catagaatcc ccagtcacct ttatatatca 240

tattattgga agagattcat cttcataatc tccagttttt tcacagtgcc tcacagagtt 300

aatcatgcct tttggagcta gaaggacttt agaacttatc tagttatgct cctttatatt 360

ataagtaagg gaatagaatc aataagacag tttctgccca aagtcatgtt accagttggt 420

gacagagctg gaaatacgta gagatctata cccttaaatc tctccactca catgctgata 480

tactttctac tacaatatgc tatagcttta tggaactcag ggtgatgatc agacgtgtca 540

ttagaacatg agtcctctgc ttctgattca ggcatacttt tgggattctt ccatctttaa 600

aggaaaaagg aagccattca tctatattta gtaacccagt aatatctcac ttagtttagg 660

gttagatctt tagttaattc aaccttatag atcatactta tgaaggtgat aactgacacg 720

tgttccctga attttaattt gataggcaat acatctaccc actccattat tttttaaaac 780

ttcatttaat agtttaaaca agattggttt tgttttcaat ttttattcac tcttcataga 840

atcacaatta cctttatata tcatatgtta ttggaagaga ttcctcagta atctccaatc 900

tctcatagtg cctcacaggg ttggtcaatg gcttttggaa ctggaaggac cttagaactt 960

atctgttatg ctcctgatag ccaatagcag atagaagctt gcaatcaaga gggtaggaca 1020

tgtgttcttc aatggatatc aaaggaagag gttgcaaacc aaagccattt ggcaagccct 1080

gtagcctggg ccatttaaga caggggcggt ctcagccaaa ttgcacccat ttaactatcc 1140

caaagagcca cagtgcctac aacccaggcc ctaagttgat gaagaaaaag tcaaggaagg 1200

aggtgataca attggaaata ttcccatcaa atggttaatc ttatttagaa aatgggcata 1260

ttagaaaaag tccttccaag atgattttgg ataataaaag ttgtatttgt ggaaattggt 1320

attatctctg ttttatgcac ttacatttat cccttacatt ttgtttttag tgaccctaca 1380

tgacattaaa tttaaagtaa aacattgttt aatgttacct tttggcttga gaatgtcttt 1440

cagctccaga attattgtta ctcatatttt aatcagtaag tcatttaagc tatgacagag 1500

taggaattga gaaattattt catatgctac agtattgaaa tgtggatgct gccttgtttt 1560

ataagaagat gatcaaggtt tgtgtgccca ttacctttcc tctgcctgaa agacgtgtct 1620

caagaaaaat aaattctatt ttagatgcag gtactgcatt ttattctaag aattgatatc 1680

aattcaaaac atagaaaact gtaaaagata aatcaggaga tggctgattc ataatgggta 1740

ataaaataaa tagcactttc gagctg 1766

133

gccaaggacc ccgatccacc ctactccgtg gagaccccct atggctaccg cctggacctg 60

gacttcctca agtacgtgga tgacatcgag aagggccaca cgctgcgacg cgtggcagtg 120

cagcgccgcc cccgcctgag ctcgctgccc cgtggccctg gctcctggtg gacgtccact 180

gagtcgctgt gctccaatgc cagtggggac agccgccact cagcctattc ctactgcggc 240

cgtggcttct accctcagta tggtgctctg gagacccgcg gtggcttcaa tccgcgggtg 300

gagcgcacgc tcgctggatg cccgtcgccg tctcgaggac caggcggcca cacccaccgg 360

cctgggctcc ctgaccccca gtgcggccgg ctcgacagcc tccctggtgg gcgtggggtt 420

gccacccccg acaccacgga gttcaggact gtccacaccg gtgcctccca gtgccgggca 480

cctggcccac gtgcgggagc agatggcggg tgccctgcgg aagctgcggc agtggaggag 540

caggtgaagc tgatccctgt gctccaggtg aagctctcgg tgctccagga ggaaaagcgg 600

cagctcacag tacaacttaa gagccagaag ttcctgggcc accccacagc gggccggggt 660

cgcagcgagc tctgcctgga cctccccgat cccccagagg acccagtggc actggagacc 720

cggagtgtgg gcacctgggt tcgagaacgg gacttgggca tgcctgatgg ggaggctgcc 780

ctcgccgcca aggtcgctgt gctggagacc cagctcaaga aggcgctgca ggagctgcag 840

gcagctcagg cccggcaggc tgacccccag ccccaggcct ggccaccgcc ggacagcccg 900

gtccgcgtgg atacagtccg ggtggtagaa gggccacggg aggtggaggt ggtggccagc 960

acagccgctg gcgcccccgc acagcgggcc cagagcctgg agccttacgg cacagggctg 1020

agggccctgg caatgcctgg taggcctgag agcccacctg tgttccgcag ccaggaggtg 1080

gtggagacaa tgtgcccagt gcccgctgca gctaccagca acgtccatat ggtgaagaag 1140

attagcatca cagagcgaac tgccgatgga gcagcaggcc tcccagaagt tcctgccgaa 1200

tcgtcttcgt cacccccggg gtccgaggta gcctccctta cacagcctga gaagagcaca 1260

ggccgagtgc ccacccagga gcccacccac agggagccca ccaggcaagc agcctcccaa 1320

gagtccgagg aggccggggg caccggcggg cccccgggca ggcgtgcgat ctatcatgaa 1380

acggaaagag gaggttgcag accccacggc ccaccggagg agcctccagt tcgtgggggt 1440

caacggcggg tatgagtcgt catccgagga ctccagcaca gcagagaaca tctcagacaa 1500

cgacagcaca gagaacgagg ccccagagcc gagggagagg gttccgagtg tggccgaagc 1560

cccccagctt caggcctgca gggacggcag cggccaagac cagccggcag gagtgtcagc 1620

tgtctcgaga atctcagcac atacccactg ctgagggggc atcaggatca aacacggagg 1680

aggagatcag ggatgggagc taagccctga cctcatctca gcctgcttgg ccctggaaaa 1740

gtacctggac aatcccaacg ccctcacaga gcgggagctg aaagtggcct acaccacagt 1800

gctgcaggag tggctgcgcc tggcctgccg cagcgacgca caccccgagc tggtgcggcg 1860

gcacctggtc acgttccggg ccatgtctgc gcggctgctg gactacgtgg tcaacatcgc 1920

cgacagcaac ggcaacacag ccctgcacta ctccgtgtct catgccaact tccccgtggt 1980

gcagcagctg ctcgacagcg gtgtctgcaa ggtggacaaa cagaaccgtg ctggctacag 2040

ccctattatg ctcaccgccc tggccaccct gaagacccag gacgacatcg agactgtcct 2100

tcagctcttc cggcttggca acatcaatgc caaagccagc caggcaggac agacggccct 2160

gatgctggcc gtcagccacg ggcgggtgga cgttgtcaaa gccctgctgg cctgtgaggc 2220

agatgtcaac gtgcaagatg atgacggctc cacggccctc atgtgcgcct gtgagcacgg 2280

ccacaaggag atcgcggggc tgctgctggc cgtgcccagc tgtgacatct cactcacaga 2340

ttcgcgatgg gagcacagct ctgatggtgg ccttggacgc agggcagagt gagattgcgt 2400

cccatgctgt attcccgcat gaacatcaag tgctcgtttg ccccaatgtc agatgaccga 2460

gagccctaca tcatcctcgg cagaagagta gccgtgaggg aggcggggac cagccagacc 2520

gggagcaaac cgtcccttgt ccccgtctcc tccctgttcc cgttcctccc tggcccaccc 2580

cactcacact ccccaaggcc cacggctcaa aggcaagcga gctctccctc tgcttccctg 2640

ggggagcccc aacggccaca ggactccagc tccaagtggg ttttcttggc tcccctgttc 2700

aaagtggcca cagcgcagac cgaagcaaaa ttcttgtata cattggcgcc agggctgatg 2760

ctggggtgtg ggttttatga agaacattga gaacaatcag ctggtaatta tggatggagg 2820

aagagggaga ggaaaaaaat attgtatttt tgaatcattg ttgcaggagg gggtgggaat 2880

cttaggattt gttgccagat ttgaaagtca ctggaacttg catattttca ttttaatcct 2940

aagtgttatt acgcaccagt tggggttcac ccttcatccc tcacatttaa ttgtctgata 3000

tagaatagtg ttgtgtccac tgccccgcta gacggctttc ttaggggaat tttcttctgg 3060

ttgtttcaca agacagattc tgtccttgtc acccgggaca gaaaactcag tcttttcacc 3120

ctcattcaga tgaagggact caggacaggc tctgtgactt acagggaccc aatcaattca 3180

caatgagaaa ttaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480

nnnnnnnncc cagaaacccc tcccttcccc acatggaggc cttggcaaat gttaattttc 3540

ctagaaaatc cttcagacct gaagacgcag gaaaagaatc tggctctcag ggtggcttct 3600

gcgtccccgc cgccaggccc cagactatgg tcacagggcc gtcctgttcc tccccgggac 3660

tccagaattt ctctcctcaa aggaaagaaa acagggcatg cgcttgttgg caaaacgcag 3720

ggccggctcc caaaaacccc atgtgtgtac gattaaaagt tggccgtccc caggcctccc 3780

agcgcaaact taaagagaca gggctttgct gaaaaccaaa catgggccag ctgggctttt 3840

taacaaccta gagactttcc ggagctgcct ggaacagagc ctgcgggaaa cggggcttgc 3900

cagagacact cacagtttcc ttcatgggcc tgttttggtc ccctaagaat ctccacatca 3960

ttgtctttct tgtgcctttt ccttggtgag caacagaaag ggaagggttc caagcctcta 4020

aaaatgtgct ttgtgatcag gagtgcgctc caaaccaaat acgcgcgctg ccctttcgag 4080

gccagtgagc tcagcctcca aggctttaaa gccacatttc agcaagagaa agcgctgaga 4140

gctcgcaggt tcattaaaga aggcaaagca ctggtttctc tccttagaaa agtaggtttc 4200

ttggcttgat gtagactggc ttgctttgat ttttagtgaa gggaatgtac gtaaaacaaa 4260

atagggcttg gctggtcaaa ggagacaagc aggatggatg gatggctggg tggatggatg 4320

tatggatgaa tagatagatg gtgtttgcat gtaaattgca gagaaaacaa aaccaaagct 4380

gattggaaac aattaattgt gggtgtctga gggggaaggt cgcagctttg ggcagctttg 4440

agaagcggta caagagttct gtgcctgtgt gtccagccct ggagccagcc agtgcattta 4500

ttttaagctc ttagaagcaa ctccttggcc caggaatgcg tgacccctga gatgggtcca 4560

cgcatctctc tacacttcct tctctccgtg ggatactgga ctcgtgcctc tgcgcccatt 4620

ctcttctcac gcatatccat gagctttaat ttcactttct gatcacggta cgtccataaa 4680

gccagtatta cacttaaatg aagtattctt ttttgtaatc gtttttttta gaaggtaaac 4740

aaatttaata aagctaccaa taatgttgaa aa 4772

134

ctccctctcc tgggcacctg ccgagcagca gaatgtgagg gagatgaaca gctggactcg 60

ggctgcagtg ctcgggccaa cgtgacgtca ccnggcggag agatgagttc ccggtggggc 120

tctggggngg gntcctgaac ggnnattcct tcctgaagcc tcatccccgc tcagccctgc 180

tcagcccctc ctcctactcc cctccccctc cccctcctgc cgggccagga attgggtttg 240

gggcgggttc tgcttccaaa gccatctctt ccagcaggag agggctctac tctgagctcc 300

tattttccaa ggctccgggc cgcgctcggc gctgggcctg ctgccccggc gggttccgcc 360

ggccggaggc gggagtcaca ggaagagccc tccacaaaag gaggcctcgg cggatcagga 420

cagctgcagg tgggtgtgca gactggtgag ctgccagcag gggcccagac gcgccaggcc 480

tggagatggc tggaaactgc tcctgggagg cccatcccgg caacaggaac aggatgtgcc 540

ctggcctgag cgaggccccg gaactctaca gccggggctt cctgaccatc gagcagatcg 600

cgatgctgcc gcctccggcc gtcatgaact acatcttcct gctcctctgc ctgtgtggcc 660

tggtgggcaa cgggctggtc ctctggtttt tcggcttctc catcaagagg aaccccttct 720

ccatctactt cctgcacctg gccagcgccg atgtgggcta cctcttcagc aaggcggtgt 780

tctccatcct gaacacgggg ggcttcctgg gcacgtttgc cgactacatc cgcagcgtgt 840

gccgggtcct ggggctctgc atgttcctta ccggcgtgag cctcctgccg gccgtcagct 900

ccgagcgctg cgccttcggt catcttcccc gcctggtact gggcgccggc ggcccaagcg 960

cctgtcggcc gtggtgtgcg ccctgctgtg ggtcctgtcc ctcctggtca cctgcctgca 1020

caactacttc tgcgtgttcc tgggccgcgg ggcccccggc gcggcctgca ggcacatgga 1080

catcttcctg ggcatcctcc tgttcctgct ctgctgcccg ctcatggtgc tgccctgcct 1140

ggccctcatc ctgcacgtgg agtgccgggc ccgacggcgc cagcgctctg ccaagctcaa 1200

ccacgtcatc ctggccatgg tctccgtctt cctggtgtcc tccatctact tagggatcga 1260

ctggttcctc ttctgggtct tccagatccc ggcccccttc cccgagtacg tcactgacct 1320

gtgcatctgc atcaacagca gcgccaagcc catcgtctac ttcctggccg ggagggacaa 1380

gtcgcagcgg ctgtgggagc cgctcagggt ggtcttccag cgggccctgc gggacggcgc 1440

tgagctgggg gaggccgggg gcagccacgc ccaacacagt caccatggag atgcagtgtc 1500

ccccggggaa cgcctcctga gactccagcg cctggaggag gcaggggcag gaagcggcct 1560

ccaagaccct tcgccttggg acaggaatgg gcacctgctt ctgagtccat acaggagaag 1620

aaagatctgt ttcctctcct cgggcctcct tctccctggg ctggggactc caggggtggc 1680

tgggagactg ggcagccacc agcaaacaga ccctgtggcc cctgcccggc tcccccaccc 1740

attctgctcc cctagagacc tcttgtacag aagttgcccc caggtggtgg ggcccctcct 1800

tgccctaggc tggttggtaa aagagaggag gtcaacaccc agcctagcca cctctgcctc 1860

ttgggtcagc cctccttgac tgtgtcccag ccagcaccag gccagcagcc tcatccctgc 1920

cattcagggc tgttccagag attcgatcct cttaaggcat tatcagtgag caaatgtgaa 1980

ggaaatggtg tctggaagaa agttctggtt cacatgcctt gtagctaagt ctttctgcaa 2040

acaacctccc ttccccccgt cgagtcattt ggtgactttg atggggggat ttctggttat 2100

gtcaaggctc tggagacagg aagggccttt ggccgccttg ggtagttgac ctgccttttc 2160

tgactccggg acgagccagt cctaggctgc ctccgggagc acttgaggta tcccgcaggc 2220

catgaggacc cactgggcag ctcctggaca gcctcttggc tccagccccc acccgaaagt 2280

ggacactggc tccgccctgg ccacctgggg actggcactg tggtgcacag tggcccaatg 2340

tggccaacgg aagttttata aaagacaaaa tgtatatcaa taaacatttt ataacttgca 2400

gccaggaagg cttcatgcnc acaaaantna gcgtg 2435

135

ggcggtggcg ctggtggctg cggcggcggc ggcggcagcg gcgctcgagc ggttcctgtc 60

agggtcagcc ggcgggcccc ctgggtggtc cacctgcaaa tcgcggagcg ggcgccccag 120

ggatcgatgg cgatgaacta taacgcgaag gatgaagtgg acggtgggcc cccgtgtgct 180

ccggggggca ccgcgaagac tcggagaccg gataacacgg ccttcaaaca gcaacggctg 240

ccagcttggc agcccatcct tacggctggc acggtgctac ctattttctt catcatcggt 300

ctcatcttca ttcccatcgg cattggcatt tttgtcacct ccaacaacat ccgcgagatc 360

gagattgatt ataccggaac agagccttcc agtccctgta ataaatgttt atctccggat 420

gtgacacctt gcttttgtac cattaacttc acactggaaa agtcatttga gggcaacgtg 480

tttatgtatt atggactgtc taatttctat caaaaccatc gtcgttacgt gaaatctcga 540

gatgatagtc aactaaatgg agattctagt gctttgctta atcccagtaa ggaatgtgaa 600

ccttatcgaa gaaatgaaga caaaccaatt gctccttgtg gagctattgc caacagcatg 660

tttaatgata cattagaatt gtttctcatt ggcaatgatt cttatcctat acctatcgct 720

ttgaaaaaga aaggtattgc ttggtggaca gataaaaatg tgaaattcag aaatccccct 780

ggaggagaca acctggaaga acgatttaaa ggtacaacaa agcctgtgaa ctggcttaaa 840

ccagtttaca tgctggattc tgacccagat aataatggat tcataaatga ggattttatt 900

gtttggatgc gtactgcagc attacctact tttcgcaagt tgtatcgtct tatagaaagg 960

aaaagtgatt tacatccaac attaccagct ggccgatact ctttgaatgt cacatacaat 1020

taccctgtac attattttga tggacgaaaa cggatgatct tgagcactat ttcatggatg 1080

ggaggaaaaa atccattttt ggggattgct tacatcgctg ttggatccat ctccttcctt 1140

ctgggagttg tactgctagt aattaatcat aaatatagaa acagtagtaa tacagctgac 1200

attaccattt aattttatat tatgaaagca aatcatctgc atgtgcatca aggccagtcc 1260

tattcaacct agctttcgaa tgctgatatc tggttagtat gtcattttga agttggcaca 1320

taacttttct aaaaaaaagc agtctttgtt gtttgcttct tccctacgga tgacttctaa 1380

aaatatatga cgggtataaa aaaattagct atattgatca tatcaacact gtaactgctg 1440

aaatggcatt ctaatgtttg ctttttattc ggacaggcca catgatgcat agagcctctt 1500

tcatgtgact tgtgtctact gcttaaatct ttatgctgtg ttgatgatat tatattgaca 1560

tatgaagctg tatatgtgta tgtattttgt ggagaaaggg attacaagat gtatgagtat 1620

aatgacttgc taacctttca ggattcagag aaagatgaag aaagaccata tctaaataat 1680

acacttcatc attttcatgt gtataaatgc ttaaagtacc atctttgttg aggtggttca 1740

tgtatccagt ttatccagta cagttatttg tcaagcttag ctttgatttc aaaggacacg 1800

cttaccttgt ctggcataag aattaatgct catgtctgca gtggttgggt aggtcctgct 1860

taggagaatt aaaaaattcc tctttccgtt tggttgaatg ttgcagtcag gaaccccaac 1920

tcacttggaa tgtttttata tgtaatcatt tcccttgaag cttatacttt ataagggaag 1980

aaagaattca ggtgatatgg gaaaactgct tggcagacct tcatcttctg cctcaactgt 2040

aaaccacatg taaatgctta atggagactg ttttcattct tgtgatattt aacattcaga 2100

aaattacttc agctttggaa atactcaggc tgtttttatt ctgcaggtaa gtgttttgac 2160

ttaagtacta atattccaga aatttttgaa agcagtaacc ttaatttcct atgtatttca 2220

ttccactttt gcatataggt caaatagcaa tgtgtatgca cattctcttt agttaaggca 2280

ccaattgttt tggttggttt tcctaagaca tactttaaaa agatgttcta taaatttcct 2340

agttaaatta tggggatttt ggagtatgta catgataaat tataatacgt atatggttga 2400

agttatttta ttttttacta atgaattatt ttaatattcc ttattgaata aatgctgtaa 2460

cttgtttgct atggaactta ttcttaaagt tctagttaaa aataattttt ccacatgcat 2520

gaaaatatgt attaatcaga ggtggcttaa ttacattgaa attgcttttt tgttgttgtt 2580

tttttactga aataactcat gtttgtgtag aagaatgcct gtttactcag agtttatatt 2640

ttccttcagt tatattttaa atcaaaaggt ctgggtaatg tatacttttg attaatatat 2700

acttttttta aaaaacaaaa aacaatgtaa tggttaatag tagaaatgtg ccacactttt 2760

caagttttat ataacatatg aaattcagtt aaaagaatgt gtgtttcata atgactttta 2820

actggtaaaa atattacttg cacgaagtac ttgatgtatg gttatcctga aatttcggag 2880

tatttggtgt gttctttgtc taaaaatagt ctgttttgtc agtccttcag aatattattt 2940

attctgaaga ttgtccctct tgcacttggc agtttatttt cggggataca ttgttggggg 3000

agaggggttt ctgccactct ttccagattg agtctgtgct gtttaaggag gactaccatc 3060

ctgcaactct ttttctaatt ggggcacaga ggatgtcgct aaagaaaagt tgaagagccc 3120

tttcagcact ttctcatctg tggagaagat ggaatcttaa aatacatttg gagttttatc 3180

tgttttacaa gtccattgat ggcctaagtt cctcctgttt tctgctgttt gatctctaag 3240

gaactcctgt tgctaaatat gaagagtatg gaacattcat atagtctctg tgaagcatgg 3300

ggggagggaa gacatttctt tttcttatag gctttatgct caaatgtcat agtctccttt 3360

caaagaattg tgttgcattt taaatgcacc cagcttaagt agaagacatt gaaggatgca 3420

ttaattttca ggaactattt tgaattatga aaagattccc aattgaaaaa attattcaac 3480

aagtaaaagc taagaaattt cattgaaatc ataaggcagt ttaagcataa attgataaaa 3540

atagctgtgt actactaatt aatagaaaat cattcaacca agagaagagt caagtgaata 3600

tcgtttgttt atttgctagt gagtttcttt gtaacgttga ttttattaaa tgataatatt 3660

tggttagtat gtcctatgtt aataaaaatg aacaaaatta attttgctat gttcaggtgt 3720

cttgataaaa taacaatgct ccagtgttgt tgcttacatt tagcactaaa ttttaacaca 3780

gggtcagtga gtccaggttt taacttcttc atgcctggat gggataaaat gtaattcatt 3840

gttaaattaa ttcatatttg tatttattaa tcactgtgac aacattaacc atttgttctt 3900

accaggaagt ggtcagatta tcatctgagt tacagttaga ctggctaagt ttggtattag 3960

atcaagggga atgtccagta aacagagagg taagcatgat ggaaataatg aagtggggta 4020

cacaggaaaa acctgactag tgaggaggag cagctgagag atagggtcag tgaatgcggt 4080

tcagcctgct acctctcctg tcttcataga accattgcct tagaattatt gtatgacacg 4140

ttttttgttg gttaagctgt aaggttttgt tctttgtgaa catgggtatt ttgaggggag 4200

ggtggaggga gtagggaagt ggtcctttta caagaatttt gatgcataag tgtctattgt 4260

agggtttgga tgatctagta aagtgtttta gaaccccttt ttatcccatg caccattcag 4320

taaacataaa aatcacaatt ctgctaatgt catttggaac ttcaaaataa atatcttgtc 4380

taaaaacaaa aaaaaaaaaa aa 4402

136

ttttacaaca caagaaatgg tactgaatat atttgttaca tcctgaatca acccaataga 60

ctatcttgta aacaaaatag taaggtaaca cttcaaaaac agatgaacaa tttatccacc 120

aagaatgtat atagtaagcc aaaagctcac tgtggaaata cacttagcat ggttattaga 180

aaatcacaaa gagtaatgta acaagttacc aaattttatg gtcatgttct gcttgataat 240

tcaaatagga tggatggtag ttactagttt tctatttgtg ttgtnttaac atctccattg 300

atttttaatg ctttattttt tatttgaatt tgctggctgg caggtttgct ttgcttaata 360

cattgactgc aacacgctta ttgttgtgtt ggtagaataa gacatacgag aatatatata 420

gaaaggccat atggaggttt ccatggaaag attctgatac tccataactc tgctgttcag 480

aatttcagct gattgcctgt agttggtgca gcgaacggaa cgctggtggc aggtgttgtt 540

gctgcagaca cagtggtagg tgtagcaccg tgcatcatgg gcacaatatt tgaagcgggt 600

gccatgcaca gtattggccc tgcagggata aatgccggct gtgggagctg caggttagtc 660

agagcctgtt ggcagtggaa aacagtggga ttaaagaccg gggtggcacc attgggcttt 720

tccagtgctg atctctttgg tatcagttgc agtgtaccag gctgcagggc catggcagag 780

gcagctgaat ggttcatctg atgatgagct gccttgagtc tggcttgcaa gtgtgcagga 840

ggatgaaagt acttgcattt ctcccgcgag catcgacctt tgatgtaatc catgcagatt 900

gtcacagtat tatcactcgc ctagttctag atccgag 937

137

ctaaaggaaa ttcacagtaa tgctgcatta aacactaagc tcacttaggt cactttctag 60

tgagctaacc gtaacagaga gcctacagga tacacgtgag ataatgtcac gtgtagaaga 120

tcgttgtgaa ttaaagttca aaattaagac ttcttagatt atgatgtaga ttttagagct 180

ccttaaaaca taaagcgaat cttataaatg ttcaattcta aagttattcc acttggaaaa 240

attagctttt gggacaattt ttaagaactt ttgtgtaaaa tgcagctcca tgtttagcat 300

aatctaaaaa taatttcaag caatccagaa tcttccaaga atttattaaa gctttaaaac 360

aaagcaaaac aaaaagaccc ttttgtgcct tatatgggaa gactccaaaa acagaaaaaa 420

atagaggaaa acaccacttc aatttgacat tcaatgcatt cacatcagaa actaagaaga 480

taacaagcct gagatgtcag gtgataaaaa ttcatgtttc ttccaaggac agaaggctat 540

tagattgtcc caggccatat ctattcccag ttctttgtga gtagtcttct tactttttct 600

gtggtaggta agaagcatat ttccaccaaa agaaagcatg cattgtttga ctagccagct 660

ttctagaaaa aatgagatcc ttgagaggat aaacaaatcc aacctattca tggtgtcctc 720

acttattgtg gtcaatttgg aaggcttaaa acacaaaaaa tgggatggat aactttgaac 780

actaaaatta gtggagccaa aggcacgtct tcaccattct gttatgtgac ttaaaattca 840

atttcacgaa acccacttcc acaagcttaa tgaactgtga gctacatgag ggcataaacc 900

atgtcttctt tgtatggtat tcctgcttcc tagcaggaca gctggcaaag agtttatcat 960

taaatgtttg ctgaatt 977

138

gtggccaagg acgccggagt ggccgccttc cccgcgcctg agcgcagtgg ggcgagacaa 60

agagacctgg gcccccagcg cacccgtctc gggccacggg cgccccagct ccgcggagtc 120

ccgcagtcgc tggcccggga cgcgcccggc ccgggctccc ttggaaggct ccctaggcaa 180

tggccgggtc tctgctccac ccggctctca ggagcgctgc tctctccatc tgatcgccct 240

ccatcctccc cattccctcc ggttccgggc tctcccttcg ctccaagcct caggccaccg 300

gcttggatgg acgctccgag gctacccgtg cgtccagggg tcttgcttcc gaagttggtc 360

ctgctctttg tctacgcaga tgattgcctt gctcagtgtg gcaaagattg caaatcttac 420

tgctgtgatg gaaccacgcc ctactgttgc tcctactacg cttatattgg gaatatcctc 480

tcgggcactg caattgcggg cattgttttt ggaatagtat ttatcatggg ggtcattgct 540

gggattgcca tatgcatctg catgtgcatg aagaaccaca gggcgacccg cgtgggcatc 600

ctcaggacga ctcacatcaa caccgtctcc tcctatcctg gaccaccacc ctacggtcac 660

gaccacgaga tggaatactg tgcagacttg cctcctccat actcccccac cccacagggt 720

ccagcacagc gttctccacc ccctccttat cctggaaacg caaggaaata atctatctcc 780

cagaacagaa catgtgccaa tgggcgatct tgcctggaat aaaatgcctc tactcagaaa 840

caggcaggaa agaattgctc caaggaatac tttttggggt cagataatgt gtcaggtgga 900

atatccctgc taggagatat aggatttcta ctctgctcaa agctgacccc atctggagta 960

ttaatgtttg gttctatgga accacatttt aagagatctg ctgatccacc taagcacatt 1020

cagggaagag taatgtaatt gacaaaatat ctgataatca tgttgtttaa gggctaggtg 1080

aagaaagttt cagtattgat cctggaaaaa aagaagatct aagtaggatg ggagaatgat 1140

ttggcccaca caaggaagca actttattct atatagcttt aaaagtcaga actagaattg 1200

ttcattcttt cattcatcaa taaatgtatt ttgagtgcct aagagtttac tatgtgccta 1260

gcactgtttg aggtcctgat ggaagttaca ggatgggtac tctggtttta gtacaagaaa 1320

gagcaatgac tagattgctt tgtgaagctc ttggtagaga cacgctccag aagggataac 1380

aaaatcaaat agtagatggg ttcattgggc ctcagaagtt ctgctcgtat tttaggtggg 1440

tgtgaagtga atttctatat gtccaggagt gaatacaaca gaaagagttg gatcttattt 1500

atttaattag ggagttaaaa caagaccaaa aagactcaac agccgcttga agccaagaac 1560

tcttcaatgc cagctactgc cacctaaaaa tcatctggct ttatagtgga tcagaataaa 1620

ggttattcta actgtgggga gaaaaaaaaa attgtatcaa gttccacagg tagcagacac 1680

ttcacttcca agtaaaagat gagaaatcaa ttattcccac aggattttag gtcagggagc 1740

aaaaatctca gaacttgacc atgaagatac acaacagact cgcaaaaata aagtgggaaa 1800

tgaagttcag attcccttct gtagatttcc ttaaaactat tatttttttc ttcttcgtaa 1860

aattttgata atctgttctc ttaaaaaagt taatgacaca attaagatac tgacatcaaa 1920

ttgttgcctt ttaccaaaat gcaaatttta tgaagtgcct acctttatat gtataaagca 1980

tttaataaat aattctaatg tgccatattt tgctgtgagt gaccttaaca tttatatttt 2040

tatatgaatt gtttcatgta tttataaaaa ttgtatattg aacattggaa atagatgatt 2100

agatttttgt gtcattttac aattaaatct aaaatgctta atccaatatc atcatcaaaa 2160

ttcagtgaaa tcccaaaaca gtgccaagaa ttttgctgaa tgaaacaatc aaacaaagca 2220

ttttaaggtg taagttatag tacctgtact tgcagataag aagcttacta tatcattatt 2280

ataagtagca tatattactt tcaaatacct atattagaaa gatattgatc tgactgaaat 2340

ataacctacc tgccagtaag gtccaaaggc tgaatttgtt ttgaatgact tccttgatct 2400

ttaagcactg atgattttct tatatatgag gatgcaaagc attcaagagt ttcagcctgt 2460

tctggtgagg ggctccctga cttacataaa gttttcagtg caattttaat agtacatatg 2520

ctttaattta tttttcttct gcgtgtggtc agacccaatt acactgtggc taagactctc 2580

aaagtgccag ggtttctgtg atgattctga gaatgctgaa tacaaatata ccttatattc 2640

tttaaggaaa acggaaagga aagatcagca gaaatagggt tttctcatct tcaccatcaa 2700

taaacattta ttgcgtacct cctatattct gcaaattttc cccaaataga agccagttca 2760

gtccacacca tctcttcttt gagttgttta tggcctccct taaggcattt tacaaaccca 2820

taagcctaca atagatgagt atttttacta tttgtattaa gtgtcataat agcatcaatg 2880

tgcacattac cagtatagac tgttggagtt cactgattgt tttcatagat gatgcttctt 2940

ggggaaaaat agtataggat gtgaaagttt tgaattacgg ttatttaaaa actaacattt 3000

gctatggcca aagtgtttac aataagcaat aaagtgaaag aacctattat aacc 3054

139

ccaaagtgaa aaagaggaac aagttctaac ccaatgcagg tttaaaacat aaccaaaaga 60

acaaaagaga gagcttgaca caccaatctt gaggttatca cgctataata gagaatggac 120

tcattaatat gggattacag aggaaggaat ggttaagaaa aagacatggc ctctgactgc 180

tccaaaaaag gataagcagg gcttcacaga agaggtgaca gaaaaggaag tggaatggaa 240

taaaatcccc caatacagta caattataca ttaatggctg taatgtgaag agcatcacac 300

acgaagagag ccatcttcca gaaataagtt tatacactct ctcctctaat tgcatcagga 360

ctttaccaga taatgttctt ccagatctga aaaggaaaat gcctaaaaga gcttccaaac 420

tcatttttga ataatactag gctacaaaga attacactgt gaattcatta agggtaacac 480

caaaccacta aacagcactg tttgtacaga aatgtcgaaa agctgtggaa ataatttagc 540

ggccatttct gtaggaattt cgcttctttt actcttagtg gtttgtggaa ttgggtgtgt 600

ttggcactgg aaacaccgtg ttgccacacg atttacctta ccgaggtttt tacaaaggag 660

aagcagcagg agaaaagtct gtactaaaac attcttgggc ccccgcatca ttggcttaag 720

gcatgaaatc tcagttgaaa cccaagacca caaatctgct gtcaggggaa ataacacaca 780

cgacaactat gaaaatgtgg aagcaggtcc tcccaaagct aaaggaaaaa ccgataagga 840

actatatgaa aacacagggc agtctaattt cgaggagcat atctatggaa atgagacatc 900

ttctgactat tataacttcc agaagcctcg tccttctgaa gttcctcaag atgaagatat 960

atacattctt ccagattcat attagctttt caaaatattg acttttgtta ttggatgata 1020

aatattcact gtaatttttc aacagcnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1080

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1140

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260

nnnnnnnnnn acagtggaag gagggagagg ttcagggaaa aaaaaaatat caggtactat 1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380

nnnnnnnnnn nnnnnnnnng tacccctgaa cataaaatta taattaaaat attaaaaata 1440

attcactgtg atttttatgg tactgatgcc attcttaatc aagttctgat aagtggatgg 1500

tctctgccta tctccacctt tctgaatcct atgtgtatcg ctgtggatta attctagata 1560

tcttctccac cctccttgca ccagactaaa tctgtattat gtgatattga ttcttccttc 1620

taaatattac ccgttatctc tttcctttat ttctaccatt atctttatct ggctcagaat 1680

tattgtcata gggctcctaa ctgttcctcc tgcttctagt ttctacccac tcaatcaatt 1740

accgatggtg ttgccagatt tatcttcaga aaatattcct aacagccaca ttatttcttt 1800

cacttaaaat gttttaatgc cccctctttg caaaagacat aatacccata atttgaactc 1860

caaaatttat ggttttccac aattggttcc aattcacttt tccagtgact tctcttacta 1920

tctctcattt ctttgccttc agcagaatca tcttaaaacc tgccaaactt atccttcctt 1980

cacagctttg cttttctgcc tcttctctca agcctgcttc agatcataag ttcttccaca 2040

catctcctga atcactccaa acccgcattt acctttttat tttctgatat aagctttgat 2100

gcctcttcaa ttcttaggac atttaaacat atgaatgttg ccacagcatt ttattaccta 2160

gcttcatatg aaaatgtctt aaattcccac ctaaatgaaa agaaactgcc caaatgccta 2220

gaacatcaca taaggcacta aatgcctcat gttttactga cgggaattga attgtacatt 2280

ttgctgagta gttttgagaa aaaaatctaa taaattcatc tgttattcat ccatacaagg 2340

gatatttgtt gtgtcttcta tctacttgct attgtgctg 2379

140

ctctagtggc taggaatgaa attctgggat aagcttgtgt taaagtagac catgtgcgtt 60

tccaaacagt gagaacaggt cactagcaaa caatggcatt ttgtttgaga aatggagagc 120

gagcaagact ggagcattac catcatgatg gcctgtcagg cttttcagag aagaaatgaa 180

ctgattaacc acaaatgcat tattccaaca agccaaaagt cttccatccc atgggccagg 240

gtaattttcc caggttagat ccagggtttg ggtgaaattt aactttaaga tgtgggtgcc 300

aaaagagaga attggcttgt ggggcctttc accagagacc catgccagtg actgaatgac 360

ctggattagg tatgcatact tgcaagcctc ttatttggga attacactaa tggttacctg 420

ttttgtgtga ccaaaaatgt tgagaactga agacatcaaa ttataactgc agtatagggg 480

cccagaagaa gggaccctca caatctatct acacactcta tttccaaagg ataagattgc 540

aagagccagg aggaccaact ccagcttctg ggatggaagg ttcagcaact ctactacggg 600

gggtcctgtt tagtcacaga gtgggctagg aaaattttgt cccagcccct taattttcca 660

gggtaagggt tgattttctg tgagaagtat ttaatgctat tctttgctaa agagccgggt 720

aaactctgaa aaattaaatc caaagctggt tatttaaaaa taactatgtt cttaacactc 780

ttgcagacaa acctaaatat cagatagaaa gtccttgtat catttctatt tgaaaattga 840

agattttatt gcctcttttc ttatgtactg caccatctta catcagagga ccagggcttg 900

ttttgacagg gattattata attgcagcat aatttgtatt agacccatgt aacaagcctg 960

tctacttcat ggaaattgca gtgggttgcc cagtcattcc agttaatcag acactcatcg 1020

tgtgggaagc ccggcattga gtttggtgct ttgatgcacg tctgagacag tgtgatgtgg 1080

ttaagcatag gaattgtgag cctctgagtg gataacctta cctatctctc atttacaggt 1140

atgtgaaaca agaagttctg ggtcctttca tcataaggga gaagcttcag aaagttccga 1200

ggacctgcta aaatcagcta ctagaatctg ctgccagagg ggacaaagac gtgcactcaa 1260

ccttctacca ggccactctc aggctcacct taaaatcagc ccttgatccc atttctgggc 1320

aatttagaca gtgaaactga ctttgtttac ctcttgcagc atattagaac agacgatcca 1380

tgctaatatt gtattttctc ttaaaacata gctttcctgt aatttaaagt gcttttatga 1440

aaatatttgt aattaattat atatagttgg aaatagcagt aagctttccc at 1492

141

gggancacna tggtaggtac agcagccagg atgccgatga gcaggactgg gagtttcaga 60

agagagatgt gtcactcggc acctatggca gccgggctgc ggatccacag gaacaggagt 120

ttgggaagag cgcttggata agggactaca gcagtggtgg cagctccagg acccttgacg 180

cccaggacag aagctttgga acgagacccc tgagctctgg gttcagcccc gaggaagccc 240

agcaacagga tgaggaattt gagaagaaga ttccaagtgt ggaagacagc cttggagagg 300

gcagcaggga tgctggccgg ccaggagaga gaggatccgg gggcttgttc agtcctagca 360

ctgcccacgt gccggatggg gcactcgggc agagagacca gagcagctgg caaaacagtg 420

atgctagcca ggaggtggga gggcatcagg agagacagca ggcaggggct cagggccctg 480

gcagtgctga cctggaagat ggggagatgg gaaagcgagg ctgggtcggt gagtttagcc 540

tcagtgttgg cccccagcga gaggcagcat ttagcccagg gcagcaggac tggagccggg 600

acttctgcat cgaggccagt gagaggagct atcagtttgg catcattggc aacgacagag 660

tgagtggtgc tggctttagc ccttctagca agatggaagg tggtcacttt gtgcctcctg 720

ggaagaccac agctggctcg gtggactgga ctgaccagct gggtctcagg aacttggaag 780

tgtccagctg tgtgggttct gggggctcga gcgaggccag ggagagtgcc gtgggacaga 840

tgggctggtc aggtggcctg agcttgagag acatgaacct gaccggctgt ttggaaagtg 900

gagggtctga agagccgggg ggaatcggag ttggggagaa ggactggact tctgatgtta 960

atgtgaagag caaagatttg gctgaggtcg gggagggagg aggccacagc caggccagag 1020

agagtggcgt ggggcagact gactggtcag gtgtggaggc cggagagttc cttaaatcaa 1080

gggagcgtgg agttggacag gcagactgga cacctgacct tgggctgaga aacatggccc 1140

caggggcagt ctgcagtcct ggagagtcca aagagcttgg ggtgggccag atggactggg 1200

gtaacaatct gggcctgagg gatttggagg tgacctgtga cccagactct ggaggttctc 1260

aggggctacg gggatgtgga gtggggcaga tggactggac ccaggacttg gcgccccaga 1320

atgtggagct ctttggggct ccaagtgaag ccagggagca tggggtgggc ggggtgagcc 1380

agtgcccaga gcccggcctg aggcacaatg gcagcttgtc tcctggcctg gaggccagag 1440

accccttgga ggccagggag ctgggggttg gtgagacaag tgggccagag acccagggtg 1500

aagattactc ctcgtcttcc ttggagccac accctgcaga ccctggaatg gagacaggag 1560

aagccctcag cttcggagca agccctggca ggtgcccggc ccgcccccca ccctccggct 1620

cccagggcct gctggaggag atgctggcag ccagcagctc caaggcggtg gctcggaggg 1680

agtcagcggc ctcgggcctt gggggcctgt tggaggagga aggagccggg gcaggtgctg 1740

cccaagagga ggtgctggag cctgggcagg gactctccac cctcctggag gccgcagcct 1800

gatggtgagg ccagccagac agaagacgtg gatggcacct ggggctcttc agcagccagg 1860

tggagcgatc aggggccagc acagacttct cggcgaccct cccaaggccc tcctgccaga 1920

tcccccagtc aggacttctc cttcattgag gacaccgaga tcctcgacag tgccatgtat 1980

cggagccgtg ccaacttggg gcgcaagcgt gggcaccggg ccccggtcat tcggcctggg 2040

ggtaccttgg gcctgtcgga ggcagcagac tcggatgcac acctgttcca ggactctaca 2100

gagccacggg catctcgggt gccatcttca gatgaagagg tagtggagga acctcagagc 2160

cgccggacac ggatgtcgtt gggcacaagg ggctgaaatc aacctctttc ctggcctgan 2220

cccctcagcc ctg 2233

142

ctctcgtcca gggacatgac gggcacgcca ggcgccgttg ccacccggga tggcgaggcc 60

cccgagcgct ccccgccctg cagtccgagc tacgacctca cgggcaaggt gatgcttctg 120

ggagacacag gcgtcggcaa aacatgtttc ctgatccaat tcaaagacgg ggccttcctg 180

tccggaacct tcatagccac cgtcggcata gacttcagga acaaggtggt gactgtggat 240

ggcgtgagag tgaagctgca gatctgggac accgctgggc aggaacggtt ccgaagcgtc 300

acccatgctt attacagaga tgctcaggcc ttgcttctgc tgtatgacat caccaacaaa 360

tcttctttcg acaacatcag ggcctggctc actgagattc atgagtatgc ccagagggac 420

gtggtgatca tgctgctagg caacaaggcg gatatgagca gcgaaagagt gatccgttcc 480

gaagacggag agaccttggc cagggagtac ggtgttccct tcctggagac cagcgccaag 540

actggcatga atgtggagtt agcctttctg gccatcgcca aggaactgaa ataccgggcc 600

gggcatcagg cggatgagcc cagcttccag atccgagact atgtagagtc ccagaagaag 660

cgctccagct gctgctcctt catgtgaatc ccagggggca gagaggaggc tctggaggca 720

cacaggatgc agccttcccc ctcccaggcc tggcttattc caagaggctg agccaatggg 780

gagaaagatg gaggactcac tgcacagccg cttcctagca gggagctata ctccaactcc 840

tacttgagtt cctgcggtct ccccgcatcc acagggaggg taaaacactt agcttttatt 900

ttaatagtac ataatttaat accaaaaaag gcgcctggat ccccaaaaaa ccgaggctgg 960

gagctagtgg cccttttgct ttctaggact tggggggccg gccctccctc ctaagcataa 1020

caaaggtggt gttgctccag ctcagcccca ggggacacag atgcactttg ggggtgaggg 1080

caggtaatga ctccatcgca ccctcagttc agctggacag aggctcaggt gaccccagcc 1140

ttcactgtct cccgctctcc aggagcttat cttcgcccca tctcccaaat aagtgggccc 1200

ttgtgctgtg aggaagacca aagcctcagg gaagataaga gatatggaga tgggaggggg 1260

aggacaaggg gcagagagta gggtctagct ggctatctct ggccttacta acacccccct 1320

ggaggcatgc cccttttctc cagcacacaa gcacattggg gcacctggaa atattggttc 1380

caggctcctg ttctctggac ttcagatcct gggggagccc ctcccccccc tgaatccctg 1440

gcttagctac cttcctgcct gtgcacctaa aaacctcagg tcagaactag gaaaagagtt 1500

ttgtttttat ttttttgaaa tggagtctcg ttctgtcgcc caggctgagg tgcagtagtg 1560

caatctccgc tcactacaac ctccactccc tggggctcaa gcgatcctcc cacctcagcc 1620

cccgaagtag ctgggactat aggtgtgtac catcacacct ggctaatttt tgtatttttt 1680

gtagacacag ggtttcgcca tgttgcccag gctggtcttg aattcctgag ctcaagcaac 1740

ctgccggcct cggcctccca aagtactggg attacacgca gaaggcacca tgcccaggct 1800

agatgtgtct tatcccaatc ctttggcagg catgcagctc cacaggcgat ttcttcaagc 1860

agctgaagtg tttagccctc ctgggttaag agccagataa ggagaaatcc ctttcctagg 1920

tttggaatgt gttgtgaaaa aaaagagaaa tccctggctc ctggagctgg tgggagacaa 1980

gattaagcaa acctcccctg acatgtatcc ctttgacccc aagctctgcc tcctccctga 2040

ccacccatgc cctttccttt aacttctcaa acagatacca gggcctaaac tgctttacct 2100

cccctcctac tgagtcaggt taggtggtgg gaggtcaccc atttccgagt taaaccaatg 2160

caatatgagt aaaacaaagt catgtgggta tgtctggggt agagagaggg gtagcaagtt 2220

catgtgtcct ccttggtcac atatctccca aagctccgat ccctgccatg ggaagtggac 2280

aggaaacatg aggtcatgac ctgcaggcat ctttactgca gctctgccgg cctggagggg 2340

gagaggggga ggaagaagta tgcgctgcac atttctgagg ctactgcatt tgctttcaag 2400

gcagaaatct tgctctgagc agtcagcggc tccagtttgg gcccgataag gaagttctcc 2460

gtggcctccc tcaggcagag cagggaggag gctgacattg ccagtctctt ctggggccca 2520

aggcaggttg caggagatcc aatcccatag acagctctgg gcctcttgca tttgagtttt 2580

tcagaattaa actgcagtat tttggaaagc ac 2612

143

ctcttgctat gtctatacca tacctgaggc cattttatct atacccttcc tatctgagga 60

ggagaataga aaagtagggt aaatatgtaa cgtaaaatat gtcattcaag gaccaccaaa 120

actttaagta ccctatccat aaaaaatctg ggtttaaaaa gtagttccaa gtaagggatg 180

cctttgtgac ccagggtttc tgaagtcaga tagccattct tacttgcccc ttactctgac 240

ttattgggaa agggagaact gcagtggtgt ttctgttgca gt 282

144

cttttttttc atcttatata taaagggttc tccattagct aataaagtcc cagaaaggct 60

ggctctcctg taagggcaga gcatcgttct gcctagtttc aaagcctctt caagtggaga 120

gcttgacacc aggctgggcg gggcaggcct ggctgaggtg ccctggtgta tatgctcccc 180

ctggcttctg gcctctggtt cccacagtgc tgaggcatgg ggtggccctg ggatgactag 240

gtggtccttc tcgaggcacc tggctcacca cttcctcttc ctaatagtga gatggccttt 300

gtcccaacag aacctgaatg gtgtgccctc gatcaccaac cccatcaaaa ctgcaaacca 360

acaccagggc aagaagcaac acccatccca ggaaaagcca caagtcctga cccccagccc 420

caggaagcag aagctgaaca gaaagtacag gtcccaccat gaccagatga tctgcaagtg 480

cctctccctg agcatatcct actccgctac cattggcggc ctgaccacca tcatcggcac 540

ctccaccagc ctcatcttcc tggaacactt caacaaccag tatccagccg cagaggtggt 600

gaactttggc acctggttcc tcttcagctt ccccatatcc ctcatcatgc tggtggtcag 660

ctgggttctg gatgcactgg ctgttcctgg gctgcaattt taaagagacc tgctctctga 720

gcaagaagaa gaagaccaaa agggaacagt tgtcagagaa gaggatccaa gaagaatatg 780

aaaaactggg agacattagc tacccagaaa tggtgactgg atttttcttc atcctgatga 840

ccgtactgtg gtttacccgg gagcctggct ttgtccctgg ctgggattct ttctttgaaa 900

agaaaggcta ccgtactgat gccacagtct ctgtcttcct tggcttcctc ctcttcctca 960

ttccagcgaa gaagccctgc tttgggaaaa agaatgatgg agagaaccag gagcactcac 1020

tggggaccga gcccatcatc acgtggaagg acttccagaa gaccatgccc tgggagattg 1080

tcattctggt tgggggaggc tatgctctgg cttctggtag caagagctct ggcctctcta 1140

catggattgg gaaccagatg ttgtccctga gcagcctccc accgtgggct gtcaccctgc 1200

tggcatgcat cctcgtgtcc attgtcactg agtttgtgag caacccagca accatcacca 1260

tcttcctgcc catcctgtgc agcctgtctg aaacgctgca cattaacccc ctctacaccc 1320

tgatcccagt caccatgtgc atctcctttg cagtgatgct gcctgtgggc aatcccccta 1380

atgccatcgt cttcagctat gggcactgcc agatcaaaga tatggtgaaa gctggcctgg 1440

gagtcaacgt tattggactg gtgatagtaa tggtggccat caacacctgg ggagttagcc 1500

tcttccacct ggacacttac ccagcatggg cgagggtcag caacatcact gatcaagcct 1560

aacgccaagt gtacaaactg gcccaaccac aggagctgcc agtatccagc agtatctgga 1620

ccacaggcaa agaaaaccac taggaccacc aggagcacac aaccccagac ccacgccgga 1680

gggcatccct ccaccagaag attccgccac ctcaagtgaa ctgcaggaat cctccaacaa 1740

ccacaaacac atgcttcgct gttagtgtct tcttcctgcc ctcagcacca cagctcaaga 1800

aaacctaaag tttcaataca agccataggn tcacagaaa 1839

145

gcggccgcgg gcaccgccag gagagcgtgc agctcgaaga gaactgcctg tgccgcttcc 60

actggtgctg cgtagtacag tgccaccgct gccgtgtgcg caaggagctc agcctctgcc 120

tgtgacccgc cgcccggccg ctagactgac ttcgcgcagc ggtggctcgc acctgtggga 180

cctcagggca ccggcaccgg gcgcctctcg ccgctcgagc ccagcctctc cctgccaaag 240

cccaactccc agggctctgg aaatggtgag gcgaggggct tgagaggaac gcccacccac 300

gaaggcccag ggcgccagac ggccccgaaa aggcgctcgg ggagcgttta aaggacactg 360

tacaggccct ccctcccctt ggcctctagg aggaaacagt tttttagact ggaaaaaagc 420

cagtctaaag gcctctggat actgggctcc ccagaactgc tggccacagg atggtgggtg 480

aggttagtat caataaagat atttaaacca cc 512

146

cgagggcgga cgcaaagaac gcggaggacc tctgggtgcc tgcaggggag ctgctccagc 60

cgggccgccg ggagcggtgg ggagagcatc gcgcagccgc ccctccacgc gcccgcccag 120

ccgcgttcgc ccactgggct ctcccggctg cagtgccagg gcgcaggacg cggccgatct 180

cccgctcccg ccacctccgc caccatgctg ctcccccagc tctgctggct gccgctgctc 240

gctgggctgc tcccgccggt gcccgctcag aagttctcgg cgctcacgtt tttgagagtg 300

gatcaagata aagacaagga ttgtagcttg gactgtgcgg gttcgcccca gaaacctctc 360

tgcgcatctg acggaaggac cttcctttcc cgttgtgaat ttcaacgtgc caagtgcaaa 420

gatccccagc tagagattgc atatcgagga aactgcaaag acgtgtccag gtgtgtggcc 480

gaaaggaagt atacccagga gcaagcccgg aaggagtttc agcaagtgtt cattcctgag 540

tgcaatgacg acggcaccta cagtcaggtc cagtgtcaca gctacacggg atactgctgg 600

tgcgtcacgc ccaacgggag gcccatcagc ggcactgccg tggcccacaa gacgccccgg 660

tgcccgggtt ccgtaaatga aaagttaccc caacgcgaag gcacaggaaa aacagatgat 720

gccgcagctc cagcgttgga gactcagcct caaggagatg aagaagatat tgcatcacgt 780

taccctaccc tttggactga acaggttaaa agtcggcaga acaaaaccaa taagaattca 840

gtgtcatcct gtgaccaaga gcaccagtct gccctggagg aagccaagca gcccaagaac 900

gacaatgtgg tgatccctga gtgtgcgcac ggcggcctct acaagccagt gcagtgccac 960

ccctccacgg ggtactgctg gtgcgtcctg gtggacacgg ggcgccccat tcccggcaca 1020

tccacaaggt acgagcagcc gaaatgtgac aacacgggcc agggcccacc cagccaaagc 1080

ccgggacctg tacaagggcc gccagctaca aggttgtccg ggtgccaaaa agcatgagtt 1140

tctgaccagc gttctggacg cgctgtccac ggacatggtc cacgccgcct ccgacccctc 1200

ctcctcgtca ggcaggctct cagaacccga ccccagccat accctagagg agcgggtggt 1260

gcactggtac ttcaaactac tggataaaaa ctccagtgga gacatcggca aaaaggaaat 1320

caaacccttc aagaggttcc ttcgcaaaaa atcaaagccc aaaaaatgtg tgaagaagtt 1380

tgttgaatac tgtgacgtga ataatgacaa atccatctcc gtacaagaac tgatgggctg 1440

cctgggcgtg gcgaaagagg acggcaaagc ggacaccaag aaacgccaca cccccagagg 1500

tcatgctgaa agtacgtcta atagacagcc aaggaaacaa ggataaatgg ctcatacccc 1560

gaaggcagtt cctagacaca tgggaaattt ccctcaccaa agagcaatta agaaaacaaa 1620

aacagaaaca catagtattt gcactttgta ctttaaatgt aaattcactt tgtagaaatg 1680

agctatttaa acagactgtt ttaatctgtg aaaatggaga gctggcttca gaaaattaat 1740

cacatacaat gtatgtgtcc tcttttgacc ttggaaatct gtatgtggtg gagaagtatt 1800

tgaatgcatt taggcttaat ttcttcgcct tccacatgtt aacagtagag ctctatgcac 1860

tccggctgca atcgtatggc tttctctaac ccctgcagtc acttccagat gcctgtgctt 1920

acagcattgt ggaatcatgt tggaagctcc acatgtccat ggaagtttgt gatgtacggc 1980

cgaccctaca ggcagttaac atgcatgggc tggtttgttt cttgggattt tctgttagtt 2040

tgtcttgttt tgctttccag agatcttgct catacaatga atcacgcaac cactaaagct 2100

atccagttaa gtgcaggtag ttcccctgga ggaaataata ttttcaaact gtcgttggtg 2160

tgatactttg gctcaaagga tctttgcttt tccattttaa gcttctgttt tgagttttgc 2220

cctggggctt gaatgagtcc cagagagtcg ttcggatggt gggaggctgc ctaggaggca 2280

gtaaatccag tcacagtgcc tgggaggggc ccatccttcc aaaatgtaaa tccagtcgcg 2340

gtgtgaccga gctggctaac aggcttgtct gcctggtttt cctcctacac gtggacatta 2400

ttctcctgat cctcctacct ggtccacccc agggctaccg gaaggtaaaa tcttcacctg 2460

aaccaattat gagcagtctc cttactgaag gtacagccgg atacgtggtg cccccggggc 2520

tggtgttggc agccgggggg aggtgcctga gggtccccac ggttcctttc tgcttttctg 2580

aatgcatcaa gggtacgaga acttgccaat gggaaattca tccgagtggc actggcagag 2640

aaggatagga gtggaatgcc cacacagtga ccaacagaac tggtctgcgt gcataaccag 2700

ctgccaccct caggcctggg ccccagagct cagggcaccc agtgtcttaa ggaaccattt 2760

ggaggacagt ctgagagcag gaacttcaag ctgtgattct atctcggctc agacttttgg 2820

ttggaaaaag atcttcatgg ccccaaatcc cctgagacat gccttgtaga atgattttgt 2880

gatgttgtga tgcttgtgga gcatcgcgta aggcttcttg cttatttaaa ctgtgcaagg 2940

taaaaatcaa gcctttggag ccacagaacc agctcaagta catgccaatg ttgtttaaga 3000

aacagttatg atcctaaact ttttggataa tcttttatat ttctgacctt tgaatttaat 3060

cattgttctt agattaaaat aaaatatgct attgaaacta aaaaaaaaaa aa 3112

147

cgggatcccg tctctctctc tcttctcttg gttcctttga atttcctccc agaaagctca 60

gatttctnnn nnnnnnnnnn nnnnnttctt cttcagtaat ccctcccctc actgatacta 120

gaagagaaga cccacaggca tgagccaagt ctctcaaata cacactcaca aacacacact 180

cctcgctacc tgaagtcatt caaaataatc ttattctcta attttcattt ctttctcttc 240

ttccttccct aggaattacc ttctcttttt gtagtcccta agccaaaata agttcacctt 300

aaaacaaatt gctagaactt ttacacagag acacgcaatt tgatggcttc ttattttaaa 360

atgcaaaaat aatctagggg cacaaaaatg caagctgggt acttaacttt cattctccag 420

atgtcttcag ccagggnccc catccagcct ccagtctgtc tgtgaaggtt agaatgtttc 480

cttcagtttg atgcttgggg ttgttggttg ttgaaggctt ttaatccctc atccaacttg 540

ttgataggtt gcaagtctcc gtaaagttct ttggggtgcc agtttgctgt tcctaataac 600

cttatgagtc tgggagctct taacttcacc ttctgggagt cttgtgggtt ccaagtgttt 660

tgctccttaa tcactgtcac agacaattga tactgccatt gatactcgtg ggcttgggga 720

ggtccccaaa cacccgtagg acctcaatcc tggctggcgt ccaggctctt gacactgttg 780

tgagaaggaa tttaaggatg agttgggaaa atactgaaag tgcagagatg tatcacaaag 840

caaaaagtac acacccggga aaagggagtg tg 872

148

gcgcccaagg tcacacagct gggatgtggc agagctgggg ttccagctcc tgttcccatt 60

gctggacagc tgccacatct ggcacccaat ttaggacccc gcggggaggc ccaagccccg 120

ggggtggcgg gggatcctag aggaaagtgg caaggccagg accctggagc agagccagag 180

tagaaaactg aggctctgag agatgaagct acttgccaag gtcacgcagc acagtcacat 240

cctactgaac atcatcctgt tctctgggnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn caggacaagt 360

gcccagtaaa cacttgggaa gcaatgcaag cgtcctccca gcagctcctg caaacagacc 420

cccgacccaa gcctttcctt ctgcctccac tgccaccact gctgctcatc tctgctggca 480

cagaagtctc ttccctggtc ttccagaaat cccctctcca cactcagcca gagggagcta 540

ttaaaactgc gggccagccc acatcagtcc acagcaaagt cctctctaag ggatctttgt 600

tgcttggaga ataaaccctc ggattccttc cttggctctc ggggcctcct ctctgacctc 660

cctctgtctc ctctcccagc cttcctcctc actcaccctc cagccatgct ggcttcctcc 720

ttgctcctga aacagcctga gagccacact gccccgggcc ctttgcactg gctgtttcct 780

ctgcctggag cacttctcct aggcatccac agggctccct cccacaactc cttcgggtgc 840

ccacatggga agccatccct gaccaccccc ccgacttcct tctgagcaag gtagggtctt 900

tctacctagt catgagggca gggatttttg tctgttgtgt tctctgtgtg cccccagtgg 960

catcccagtg cctggcagat ggtaagtgct cgacacacat tggctgactg cctgaatgaa 1020

caactctatg agccgatggc agataaggac actgaggtcc tctggggtag gtgaccagcc 1080

caaggccaca cagctggtct gagattaggc caggagagga gcccgggttg gtcacatcct 1140

ggagttggcg tcttggaaac tgcatcagga gaataacaaa gatgagacgc aggctctaac 1200

aagtggatac cagtgactct cgccccgcca gccccagccc tgcagccttg ggcccttcca 1260

ggagtcatgg tctgcctgcc tggggcattc caggcttcga cccaggtcct gcactttcta 1320

ttttgagcct cttagtcctg aggactgtgt gttcccagca ggcggcgcgg gccagaggct 1380

gagcctgggt gtggctgtca ccctatctgg ggccagagac ccagattccc gggcccttaa 1440

cctgttggct gctgagggct ctggcataag ccctgttccc tgcttgattg tctccccttc 1500

aagcccctgc cctggtatcg tatcggccca tctcaccttg gattatatcc ctgtttggcc 1560

ccatttgaat cctggctctg cccctttcca gcaatg 1596

149

gcccctgggg tngggacaca atcaccccag gttgagatcc atggagccag gtctgtttgc 60

caccaaggtg taaagctcca ttcccacctt aggagggcta ggaggcagca tcgtggggcc 120

acagaaggcc tgggtttgca gtcagaggac aggatgcaca ttccttcaag atacagaccc 180

agattgttgg gcatctagtt cttgggtttt ctgttgttgc tgttccgttt tgtctgtctt 240

ccctcctttg tttactagca gcctgggaat ttgccacttt ttctaaacga agatttatgg 300

gaacacttac cacacggctg acgctgcgca ggctaaggtt ctaatacacc gcagctcact 360

taactcttcg caataccata aacggcacac tgtttcatct tggacccttt cttggggaag 420

gtgacagaga ggtaggaggg caaacatctt gtgtgccccg tcccaagggt attaactggt 480

ggaataatat ccgcccccca ccccagtttc taatttgctg taggctgtga cgctgtgggg 540

caagactagg gagtcctgtt gaaattagga ataagtgtgc tgtgagggaa gggctgcctt 600

attttagagc acagattttc tgaatatcta ttttgacagg ttcgatcctc tccccttcct 660

gccttccttc tgtcgatttt caatgtcttg atggtgtccc acctgagtgg cctttagaga 720

tgtgagttgt gaggcactgg ggaggcaggc acacgtcctc cagcccaaga ctgcctaatt 780

taacagggat ttctgcattc tggaacaagc ctccattttc cccaagcagg attactccag 840

agggcaaaac acagcccaat agtatcacat ttcctttctg ctttagcaaa aataaccact 900

gatcattaca ggaagcttca gaaaccgtgg gaccagtgta gaagaatgga ctatctgtcc 960

aaactaagaa taaaaatttt gacacttgt 989

150

ccggcgtccc ctccgtgagg tcgcgcccgt tcgcaccgcc cccgcccgca agaaagatgg 60

cagtggcctg atccgggccc gttggcggcg tcactgacgc ttacgctccg gtcctcggat 120

cccgagcgcg gggaggcaga ccgactgtga gctgcttgtc cccatcctgc ggccgtcctg 180

gggacacaga gccctccgtg gtgcccgggg attggattgg agccaggacc tcacttcctc 240

ctctgcccct gcccctgccc ctcccagcac ctggcccaca ccctgcagcc cgccccatgg 300

tctggccctg ggtggcgatg gcgtccaggt ggggttcccc tcattggcct ggctccgtgc 360

tgcctctggc tcctgggggc agtccttctg atggacgcgt ctgcacggcc tgccaaccac 420

tcgtccactc gagagagagt agccaacagg gaggagaatg agatcctgcc cccagaccac 480

ctgaacgggg tgaagctgga gatggacggg cacctcaatc gcggcttcca ccaggaggtc 540

ttcctaggca aggacctggg tggctttgat gaggacgcgg agccgcggcg gagcgaggaa 600

gctgatggtc atcttttcca aggtggatgt gaacactgac cggaagatca gtgccaagga 660

gatgcagcgc tggatcatgg agaagacggc cgagcacttc caggaggcca tggaggagag 720

caagacacac ttccgcgccg tggaccctga cggggacggt cacgtgtctt gggacgagta 780

taaggtgaag tttttggcga gtaaaggcca tagcgagaag gaggttgccg acgccatcag 840

gctcaacgag gaactcaaag tggacgagga aacacaggaa gtcctggaga acctgaagga 900

ccgctggtac caggcggaca gcccccctgc agacctgctg ctgacggagg aggagttcct 960

gtcgttcctc caccccgagc acagccgggg aatgctcagg ttcatggtga aggagatcgt 1020

ccgggacctg gaccaggacg gtgacaagca gctctctgtg cccgagttca tctccctgcc 1080

cgtgggcacc gtggagaacc agcagggcca ggacattgac gacaactggg tgaaagacag 1140

aaaaaaggag tttgaggagc tcattgactc caaccacgac ggcatcgtga ccgccgagga 1200

gctggagagc tacatggacc ccatgaacga gtacaacgcg ctgaacgagg ccaagcagat 1260

gatcgccgtc gccgacgaga accagaacca ccacctggag cccgaggagg tgctcaagta 1320

cagcgagttc ttcacgggca gcaagctggt ggactacgcg cgcagcgtgc acgaggagtt 1380

ttgagcgccc ggccgcgccc cgcgccgccc cccacgcacc nccggggcgg cctcgcgggt 1440

gactccgggc tccgtggctg tcccggaccc cacctcttcc ctgccgcccg ccaccggccg 1500

accgaccgcg gctgccccag ttgatgagcg gcgtgtcccc tctgcagcgc gcaccccggc 1560

ggggctttgg ctgtgacgcg gtcggggcgc ggggctgggc tgtggccccg cggcgccgcc 1620

tcctccctgg tccctcgaaa tcgtggcatc tcacttctga gaacgaaatc tcgcttcagt 1680

cactctgccg aaggcgctga cggcatcgcg gccggaacct ctgggcccgg cccctcccag 1740

ggccgccgct ccgtgggaaa aaacagctcc tccatttcct tgaaaactga acgattatta 1800

aaaatagatt aaacttcgct ggaaatgagt agccaggaag ttcaggggag ggtgccgggt 1860

ccttcccggg cctggcgtgt cggagccacc caggtcccgc agctgccgct gagaaaatgc 1920

aaatatttgt tgtgacaaga atcacataca tttactttaa atatagttgc cttttttggt 1980

cagcttcaaa aa 1992

151

gctgangcca gggcaggggc tgggatgatg gcgcgggaga ggctgtgtcc tcgcgtgtca 60

cccaccagcc ctcgagcaga ggcaggcttg gagtctgcag ccaccctggg aatgtctgtg 120

cttcctcgtg gagctgacat gatggtgaaa taggttcaat cctccaccta cccagggccc 180

agacccttcc ctggttctac cgacctgatg tggacccaga ggtggccaaa gacaaggcca 240

gcttccggaa ctacacgttc aggtcccctc ctggaccgtg tcttcaccac ctacaagctc 300

atgcacacgc accagacagt ggacttcgtc aggagcaagc atgcccagtt tgggggcttc 360

tcctacaaga aaatgacagt tcatggaggc cgtggacctg ctggatgggc tggtggatga 420

gtcggacccg gacgtagatt tccccaactc cttccatgcc ttccagacag cggagggcat 480

ccggaaggcc cacccagaca aggactggtt ccacctacgt cgggctcctg cacgacctgg 540

ggaaggtcct ggccctgttc ggggagcccc agtgggctgt cgtcggcgac accttccccg 600

tcggatgccg tccgcaggcc tccgtggttt tctgcgactc caccttccag gacaaccctg 660

acctccagga tcctcgatac agcacagagc tcgggatgta tcagccccac tgtgggctcg 720

acagggtcct catgtcctgg ggccatgatg agtacatgta ccaggtgatg aagtttaaca 780

agttctcact gccccctgag gctttctaca tgatccggtt ccactccttc tacccctggc 840

acacgggccg cgactaccag cagctgtgca gccagcagga cctggccatg ctgccctggg 900

tgcgggagtt caacaagttc gacctctaca ccaagtgccc ggacctgccg gacgtggaca 960

agctgcggcc ctactaccag gggctcattg acaagtactg ccctggcatc ctgagctggt 1020

gaccctcctg ccacccaagc tgctgctgga cctaggcctg gccctccgcc tgcctggaga 1080

ggcctggccc tgggcaaaca gccgccatca gggttcacct cggtggggga ccccactcac 1140

ccccttaggg tcgccacccc tcacggcaac ttgtgcctgg cgtcaataaa gacctggaag 1200

gatgttgtgc ttctgaagcc ccactgggtg ttactgcagc agggcgtggc cnaggccgan 1260

ggatggtgcc agcagggtgg aggncaagtc ccagg 1295

152

aggacataga agaaggggtt aactggcccg gatctcctcc tcgccttcca agcccgctaa 60

gcactggggt tatctaccca ttccccagaa ggggagactg aggcagccca ccagccaaag 120

gaggcgacca gactggggct gcgttttacc atttcagaag cggcttgagc tggtctgagc 180

tataataata aacactggcg gtggaggcga gggcgaccac agggctgagg tcagggctag 240

gattccggtg tctctacgta ggttgcttga atggggggca ccctggcatg gacnnnnnnn 300

nnnnnnnnnn nnnnnnnnga gtcagacagc ctanaaccgt cgtgcaccgt gtcctccgcg 360

gatgtggact ggaacgcgga gttcagtgcc acgtgcctga atttcagtgg cctcagcctg 420

agcctgcctc acaaccagtc tctgcgggcc agcaacgtga ttctccttga cctgtctggg 480

aacggcntgc gagagcttcc agtgaccttc tttgcccacc tgcagaagct tgaggtcctg 540

aacgtgctac gcaacccctt gtctcgtgtg gatggggcgc tggccgcccg ctgtgacctt 600

gacctgcagg ccgactgcaa ctgtgccctg gagtcctggc acgacatccg ccgagacaac 660

tgctctggcc agaagcctct gctctgctgg gacacaacca gctcccagca caacctctct 720

gccttcctgg aggtcagctg cgcccctggc ctggcctctg caactatcgg ggcagtggtg 780

gtcagcgggt gcctgcttct tggacttgcc atcgctggcc ctgtgctggc ctggagactc 840

tggcgatgcc gagtggccag aagccgggag ctgaacaaac cctgggctgc tcaggatggg 900

cccaagcccg gtttaggctt gcagccacgg tacggcagcc ggagcgcccc caagccccaa 960

gtggccgtgc catcctgccc ctccactccc gactatgaga acatgtttgt gggccagcca 1020

gcagccgagc accagtggga tgaacaaggg gctcaccctt cagaggacaa tgacttttac 1080

atcaactaca aggacatcga cctggcttcc cagcctgtct actgtaacct gcagtcactg 1140

ggccaggccc caatggatga agaggagtac gtgatccccg ggcactgagc ctaagatgtc 1200

ctaacctcca cccagaaccc cttcagtccc tgctgggtga ctcagggcgt cctaacgcct 1260

ccatggcctc agtttcccca tctgaagaat gggtacagga aaggattgtc cttgaggccc 1320

caggaagctc tgccgccccc tccctgtccc tcatgccgct cctcagctcc ctcagctcct 1380

agagggggaa gaggagagac ccccaacaag gggacaggag ggtcactgtg ccaatcctgt 1440

catcaccctc ctgtggatgt acaggcagtg ctcaataaat gcttcgaggc tgatgaggct 1500

gctggctcag ggtgcgtggg ttcctcaagg tggggatttc tgagttctaa gaccaagtct 1560

ccatctgaga ctcccaaatt gctccccacc tcccatccct gtnnnnnnnn nnnnnnnnnn 1620

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920

nncctccctt ctgcccctct cagggcccct tcccaggtcc ctgatctcca ggcttggcct 1980

ccagagcagc ccacaccacc cccaaaataa aaaaatgtat atattccttt 2030

153

agcttttcca ccccaggaat ctctgttcct tctctgtctg cctctccaca gcccgtgatc 60

ccctgcttct gggctcctac cactggacag tcattgtgga tagagcagcc tgctgctctc 120

aggaccagag aagggaaatg acttctccag gcagaggcag atctgagtct agaacccagg 180

cttctaaatt tctaggccag tactactgct ctcaaaagag attaactggg attaagtgag 240

atgacgcatg taaagatgct gtgtaaactg taattcttaa taccattatc acgcattact 300

agaatcattt cattatttct gcttcctggg ggaaggatgc agaaggagtc tgatgctcaa 360

catcccttac ctcctttcgc tgatggccaa agcaaaggag agtcctggga gcccacaaga 420

tccaggcaga aggagatggg tttggggctg gccccatcct ggcccagcct cttaacctct 480

tcttaccctg aatgtgtgcc ctatcttttc tcccacctcc ttcctcctac cacccagccc 540

tatccattct ctccttccct ctccagcctg ctgtataagt aacatgtggg tcataccttg 600

aacccccctc cgcccccatg ctctctgtgg cctccatgcc ttcaagactt ctgtctgtat 660

ctatctcaca ctgcaccaag cacccactgt gcaccaggca ctaagtctct agcctctttc 720

tcccttctgc tcccatccaa gaaagacagt gtataaggaa catctctgta attgtgtccc 780

ctctcatcta tgctctttcc tgtcttcctt gaccaaagct ctctttgagg tccaaaaaag 840

gctgccctgg gccatatgtg ctatggagag gactctccca aacccccaat agctagtgac 900

agccacttgg cctcactacc agaagaaggg tggagtcaga aaccaaagtg acctccagag 960

ctgtcctcct ggcacctgag tgtccttgct ctagaggttc aaaggcagca aggcagtgag 1020

ctatgagccc agcatggatg tgtctcaggc acctcatccc caccccatct caccccaaca 1080

aactcctcta gaagaagcca agaatttctc tctatgtctg tttcactttt tggattgcat 1140

ctccccaaaa actaaatgtg aaatccctac catttctagc ctctattgcc cagattggag 1200

tcagaggtca aaaaaggatt ccaagtgatg gaactccagg ggtggaggga aattggcagt 1260

tcctggcatc tcttgtgtac cagctgctgt gctgggtgcc ttgcatgcac ggggcttatn 1320

tgatcttcct caaacttcag ataggttagg gaaggacaaa ggcccccagc catgaagggt 1380

tttgctattt ccaaagcttc cccttatcgt cccctgtgat tatctcccaa ccccgtgaca 1440

aaggtagagc acannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngact 1500

ggtctaaagt ctcacaggta gtatatggtg gagccaacac ttgcactcag acctttttac 1560

acaaaatccc atgatttttc cactgagaca aatcctaggc tcctgggagg ccctggcaga 1620

agccagaaca catggctggg cctttccagc ccaacccact gtcttgcagt ggacggagag 1680

ccttggcgag ggcagcaggg tagagaggac aaagaatgtg gggctggttt ctgcccttta 1740

agagcacccg gtcagtcaga gaacagagat cacacacacc aaaccagaca gaggcagggc 1800

agcatggaga caggtagaca gacctccagg tccctaagct ggggacagag aaggttctga 1860

gctgtcccat actcccactt tgtgccaaat gactttgcac ctgcaaatgg tgcttcaatg 1920

tcgttttgta tctttaagct gtgatgttgt atatatacaa tgcctcccag ctagactgta 1980

agccctttgg ggacaagggc tgcttccagt tcttggatgg cgttctccta tctaccttcc 2040

ttcaactgct ctgcatataa taagcactca ataaatgctc atttgcc 2087

154

tgctgcccag acaagctgaa ggaccacagg aaaagccatg gagacttcag catcctcctc 60

ccagcctcag gacaacagtc aagtccacag agaaacagaa gatgtagact atggagagac 120

agatttccac aagcaagatg ggaaggctgg actcttttcc caagaacaat atgagagaaa 180

caagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncctcc tcatcttctt catcctcctn 240

ctcctcagag agcaatgatg aggaccagca acccagagca accggaaaac atcgacggag 300

cctgggggct ggataccccc acgggaacgg ctcacccggt cctgggcatg gggagcctga 360

cgttttgaag gatgagcttc aactctatgg agatgctcct ggagaggtgg taccctctgg 420

ggaatcagga ctccgaagga gaggctctga cccagcaagt ggagaagtgg aggcctctca 480

gttaagaaga ctgaatataa agaaagatga tgagtttttc catttcgtcc tcctgtgctt 540

tgccatcggg gccttgctgg tgtgttatca ctattacgca gactggttca tgtctcttgg 600

ggtcggcctg ctcaccttcg cctccctgga aaccgttggc atctacttcg gactagtgta 660

ccgtatccac agcgtcctcc aaggcttcat ccccctcttc cagaagttta ggctgacagg 720

gttcaggaag actgactgag gccacttcca ggtgggcagc agaggcaggc cccagtgtga 780

ccaccactgc gacccctgag cccacaaggg cagagcagca ttctgagaga cgcacaggag 840

accaagccag accaataaac agaacacttt tccttc 876

155

gtgagactcc gctgaaaatt aaaaanacaa aaacaaaaaa ccagaaatgg tacttgtgct 60

atgatgattt aaatatgtgt atattcattt atacacaata tgactgtaaa gtaataagac 120

tggttttgtg taaccctgct tacacatttt tttcagacac actgtaacct attatctatt 180

atatgttatt aggttttaaa tttatattat attaagagac tgagtgttat caactttcgt 240

ttgtttcatt ttatgtaagg caatatacaa gaatatttgg acagcttttt ggaaatgttc 300

ataaattttg atctgttcta ttcatgtaac tatgtatgta catgcacatc tgtatatgca 360

ctatgttata tctatattat agatcttagg taacaacaaa catatttgtg tgagtcaaa 419

156

gcgcggaccg ccgggagcta agtggaatcc cggttggctt ggggcgcagg cttccaactt 60

cgtactctgg cctctggcgt ctcggctcgt cggttgggta cccgaaccca gctactgctg 120

cttgaagaga agatggatgg ggactcctcg ccgtcgctgc gccgccggcc ttccctgggc 180

ggacgtacac ctttgcgaac gtcagtgagg acccagggcc cctccttgga atagctctta 240

tttctcaagc gctgcagcgt gaagctcgct ctgcgggtcc gagaggcctg cgatctgaag 300

actgaaaact gggaagagac gctctaccct gtgctcctcg ccggcttcga taggagccgc 360

aggtgcctgg gattttctca aactttgtcc caaacttcag ctgtgggagt ggaggaacaa 420

acaggcctct cccagaattg tgaaagagat cgccctggtg gatgaaacaa aaacaaatgc 480

acttgacttc caccgcctgc ctggcgtgtc acgcgggttt aatgtatgtg tcacatttaa 540

attcaaagta ttttcttcta agggcctgga cacatttctt ttctccctgt atcgtgaatt 600

ggaaaatacc ttaggatatt aaaagttatc taagataacc ccctttcttc tgtaagttaa 660

atactaaacg gcttaagacg aaattttgga atatagagat gatgatgcag actgcagtga 720

attatcaaat atgcatctca ctgttctcca cattaaacat atttttgttg cgtaaattca 780

tgttaagacg tctataacaa ttacactttg gtaaaattgt tggatgttaa catctctgat 840

agctcccaat agaaatctct gatgtactaa ccagactggt aaaccattat catgcacttt 900

gaaaatataa taaaatatta taattaaagc tgccattaat gaaataggct gagcaacaat 960

aaatttacaa aggaaaataa aagtggatag ccttgggagt tctcacataa aatatggaga 1020

tttcaaagtt aaacttgatt aattatgtta gggtaaaaag tgaattaaag caacaggact 1080

atttataaaa taattagatt tagaaagcag tcgtagaaat ataagcctgg agttgcctct 1140

gaattacata tttaacaaac ctagaagcta aatcagtttg tcttttatca aaactgcaac 1200

tcctctaagt tgaaagcaca gtgacaagag aaagcattac aaattcttga gaaataatag 1260

aaattaaagc tcttttcaaa cctgtgaaca agtatagtac cagaagtata agattcagat 1320

aggcccaagt tgtagttctt gttatgagtc ttacaaccct atggactttg gacaaattac 1380

ttctctgcgt ctgtttcctc atctgtaaaa tgaaaataat ttctgtttca tacaggtata 1440

gtctaaatag gggataatta cacctacttc aaagttgtaa aatacacaat tacaact 1497

157

gtctgggatt attttaaaat tatatatata tatataaaga tatattctta catcttttct 60

ttgccctctg tgctttgaaa gcactggata aattgtttgg ttttgctttt ctctcttcca 120

caaaattgga agcttttttt aaaaatgttt tccccacaag tcatcttgcc ttgtggcatg 180

tctgtctagc ctcttcctcc ctccctcatg atgaagtgcc atttctgtta cgtctccctc 240

tccccaagct cagaggtgct cagaggtacg agatacccaa gtttgtcagt tgagattaaa 300

agtaaggaac agagaatgtg caataccgtc tggctggggg ctgtccctgc cctgccctga 360

gctgagtcct ttccctggga gccaggccac cttagaatgg ggtttggaag taagatgtat 420

agagttgggg aatcatggag aaggaaagcc tatagtcgag tgcctgctta ggtgctgagg 480

tcacagggga gatggtggaa tcttccctgt ttttatcccc tcagggtcag ttacatagaa 540

gctgcttctt gactagtata gctcggtgac cctttgttca accgctgagg tttgatttct 600

taccctttct tctccccatt ttcatactct tcccagggat tagtgatgga ggtgaggtct 660

ccctaatcat ggtaaagtgt taaccttcca cctcctccct tccctcctcc ttcctcatcc 720

ttctgtcttc ctcaattctc cgtctctttt ttttcatcac tgattgcctt gtgtccctcc 780

aagtctactt gttactatcc atctccaggc tctgggccgt gtagacacta aacctcatgc 840

cctaaggaca ggaggaaaga ccctctgttt ggagcattat tagtagagtg aggatcccac 900

cagttctgcc tggcttcctc catccccaga ggcactaaaa gcagtatttt aaggttggtg 960

tcttactccc tggaagcctg aaatgggtgg aatagcggta aggcttgagt aaaactaggg 1020

gacagaggtt cttatttgtc gattttattt tataatttga ccacagcatc tgaactccct 1080

ctctccctgg aataagtatt tttcccacat ttttggatat atgtatggta gacaattttt 1140

ttttaagaca cagagataaa tgttttcctg ctttggttac ctttcctttc ccctttaaaa 1200

ggaattagct atagaactgc tttgtaaaga tgcttcttga tattttactt ttgttccttt 1260

tccctaatca ttcccttttc tccccactcc tccagaaggc ataacccttc tctccacacc 1320

ccctaccccc acccccgtcc taggctccca tcctttccat caagaccttc attagcttat 1380

gatatttgct gccgagatgt tataacaagg actcgttcat gtatataagc tatttcttga 1440

tccatttaaa aggaattgta cattgtgtag aaaaaaaaaa aacctgaaaa agagaaaaa 1499

158

ctgcgctgcc agctcaggtg agccctcgcc aaggtgacct cgcaggacac tggtgaagga 60

gcagtgagga acctgcagag tcacacagtt ggccaccacc atctctagat gggaagacag 120

aaagtagtta ctttcccaag atctccccac aagcaagtgt atccttgggg tttgtacacc 180

tactttcacc atggggctct gcctgccccc gcccctgcct cctctcgctg accaattgag 240

ctgtgagcct ggagcagatc cgtgggctgc agacccccgc cccagtgcct ctccccctgc 300

agccctgccc ctcgaactgt gacatggaga gagtgaccct ggcccttctc ctactggcag 360

gcctgactgc cttggaagcc aatgacccat ttgccaataa agacgatccc ttctactatg 420

actggaaaaa cctgcagctg agcggactga tctgcggagg gctcctggcc attgctggga 480

tcgcggcagt tctgagtggc aaatgcaaat gcaagagcag ccagaagcag cacagtcctg 540

tacctgagaa ggccatccca ctcatcactc caggctctgc cactacttgc tgagcacagg 600

actggcctcc agggatggcc tgaagcctaa cactggcccc cagcacctcc tcccctggga 660

ggccttatcc tcaaggaagg acttctctcc aagggcaggc tgttaggccc ctttctgatc 720

aggaggcttc tttatgaatt aaactcgccc cacgc 755

159

gcgcaggtcc caccccgcct gcncgcnccg cccattggtc ccgagcgcga tgacttggcg 60

ggcggaccag gaaggaaacc gctcccgagc acggcggacg gcgtcgtctc ccggccagtg 120

cagctgccgc taaccgccgc cctctgcccg ccggcccgtc ctgttctacc cccaggcatg 180

agcgggcctg cgcgtctaca gcacgtccgg tcaccggctc ccgcgaaatc aagtcccagc 240

agagcgaggt gacccgaatc ctggatggga agcgcatcca ataccagcta gtggacatct 300

cccaggacaa cgccctgagg gatgagatgc gagccttggc aggcaacccc aaggccaccc 360

caccccagat tgtcaacggg gaccagtact gtggggacta tgagctcttc gtggaggctg 420

tggaacaaaa cacgctgcag gagttcctga agctggcttg agtcaagcct gtccagagtt 480

cccctgctgg actccatcac cacactcccc ccagccttca cctggccatg aaggaccttt 540

tgaccaactc cctgtcattc ctaacctaac cttagagtcc ctcccccaat gcaggccact 600

tctcctccct cctctctaaa tgtagtcccc tctcctccat ctaaaggcaa cattccttac 660

ccattagtct cagaaattgt cttaagcaac agccccaaat gctggctgcc cccagccaag 720

cattggggcc gccatcctgc ctggcactgg ctgatgggca cctctgttgg ttccatcagc 780

cagagctctg ccaaaggccc cgcagtccct ctcccaggag gaccctagag gcaattaaat 840

gatgtcctgt tccattggca aaaaaaaa 868

160

tctcagctgt agaatggaaa aatctgtttc agttttaagg attgaattca aatgtgtaaa 60

tagcttaaga gtatccggca taagcactat agaagcgtct gctattactc tgcagagtgg 120

cagtggtgaa ttatctgata ttttttcctt aacttgaata gcaatccaca ttacaatgga 180

taacaatacc cattgtttat gatttgaggc atccaattat aactgtatta ttgaagtgtt 240

atcaaattac caaggctgta gggtatattt agtattccta gttaaaggtt tgaactaatt 300

tgtatactag ggcatgtttc ttaatgggaa gggggtgaag gttataataa aagtcacccc 360

taatgcttgt ttaaaattaa agaggaattt gtnggcctgg gaccaacctt agacttatcc 420

aggccaaggt atgttgtttg acgaacaccg caggatacct gatgtgcatc cccgtctgag 480

aactgttaac tataaaagtt tgactttgga aatgaagaaa aattaccttt tagcctaatc 540

atgaagacta ggcgtcaaac caaaacaaga tgcatcagtt actgtagcaa cacatttttt 600

ttaaaaaatt gcttgttgtc acaatgaagg gtgtgtatct gttttccagt atgcaattct 660

aatgccaaat gtctgcctta aaaatagcaa aggagaccat caggttaaca taaaggaaaa 720

ctgtagttgt gtgactcatg tgtctgtaga ttgtaatttt ataattacaa tttttataag 780

ataaaaaact accagttgta aattcaacca aaaaaattta aagctttgat ttagcttttt 840

gctttaactt gggtagtaac tgaaatataa aggaagaaaa tctattaaaa ccaatgaggt 900

tttatatttt tttaaatctt gattcaataa atatcagctg aattaagtat ctgtatggta 960

ctacgaagca atcaattagt ataaatggca atttacaagt tcaacagtaa atgtaaacat 1020

tctttgtatc taggattttt gagttgcaag ttaaactgaa tttttactgc agtagagagg 1080

aggagcatag caggcaaaat aacaggtaat actgtatttt aaacaaacag aaaaacccaa 1140

gtaattggcg ccctttatcc aatcatcttt taaaaggcct atgtatgtgt atagttatgt 1200

tcttaagaaa catcttaaga ggttcagaaa tcaattttat agatggaaca ttttaataat 1260

tcgttttggc ctagccaaaa gagtaaaata aaacaaaata gtgttagatt tctgtgaggt 1320

gttttaattg ccttttctgc 1340

161

tttgcaaatg tactgtattt ttaactttta tttagaacag aggtctcttg gactctcagc 60

cccaggcttg actactttgt gccactggga gtactccctt tcctcttctt cacaccatca 120

ggaaaggcag gctgagagtt acgctgcttg actctgcctc ggtctatccc acaggtgatc 180

acttactcca gtcgtcatgt ctacaataac ttgactgagg aacagaaggg ccgagtggcc 240

tttgcttcca atttcctggc aggagatgcc tccttgcaga ttgaacctct gaagcccagt 300

gatgagggcc ggtacacctg taaggttaag aattcagggc gctacgtgtg gagccatgtc 360

atcttaaaag tcttagtgag accatccaag cccaagtgtg agttggaagg agagctgaca 420

gaaggaagtg acctgacttt gcagtgtgag tcatcctctg gcacagagcc cattgtgtat 480

tactggcagc gaatccgaga gaaagaggga gaggatgaac gtctgcctcc caaatctagg 540

attgactaca accaccctgg acgagttctg ctgcagaatc ttaccatgtc ctactctgga 600

ctgtaccagt gcacagcagg caacgaagct gggaaggaaa gctgtgtggt gcgagtaact 660

gtacagtatg tacaaagcat cggcatggtt gcaggagcag tgacaggcat agtggctgga 720

gccctgctga ttttcctctt ggtgtggctg ctaatccgaa ggaaagacaa agaaagatat 780

gaggaagaag agagacctaa tgaaattcga gaagatgctg aagctccaaa agcccgtctt 840

gtgaaaccca gctcctcttc ctcaggctct cggagctcac gctctggttc ttcctccact 900

cgctccacag caaatagtgc ctcacgcagc cagcggacac tgtcaaactg acgcagcacc 960

ccagccaggg ctggccaccc aggcatacag cctagtggga ccagaggtga gaggttctga 1020

accaaagaaa gtccaccatg ctaatctgac caaagcagaa accacaccca gcatgatccc 1080

cagccagagc agagccttcc aaacggtctg aattacaatg gacttgactc ccacgctttc 1140

ctaggagtca gggtctttgg actcttctcg tcattggagc tcaagtcacc agccacacaa 1200

ccagatgaga ggtcatctaa gtagcagtga gcattgcacg gaacagattc agatgagcat 1260

tttccttata caataccaaa caagcaaaag gatgtaagct gattcatctg taaaaaggca 1320

tcttattgtg cctttagacc agagtaaggg aaagcaggag tccaaatcta tttgttgacc 1380

aggacctgtg gtgagaaggt tggggaaagg tgaggtgaat atacctaaaa cttttaatgt 1440

gggatatttt gtatcagtgc tttgattcac aattttcaag aggaaatggg atgctgtttg 1500

taaattttct atgcatttct gcaaacttat tggattatta gttattcaga cagtcaagca 1560

gaacccacag ccttattaca cctgtctaca ccatgtactg agctaaccac ttctaagaaa 1620

ctccaaaaaa ggaaacatgt gtcttctatt ctgacttaac ttcatttgtc ataaggtttg 1680

gatattaatt tcaaggggag ttgaaatagt gggagatgga gaagagtgaa tgagtttctc 1740

ccactctata ctaatctcac tatttgtatt gagcccaaaa taactatgaa aggagacaaa 1800

aatttgtgac aaaggattgt gaagagcttt ccatcttcat gatgttatga ggattgttga 1860

caaacattag aaatatataa tggagcaatt gtggatttcc cctcaaatca gatgcctcta 1920

aggactttcc tgctagatat ttctggaagg agaaaataca acatgtcatt tatcaacgtc 1980

cttagaaaga attcttctag agaaaaaggg atctaggaat gctgaaagat tacccaacat 2040

accattatag tctcttcttt ctgagaaaat gtgaaaccag aattgcaaga ctgggtggac 2100

tagaaaggga gattagatca gttttctctt aatatgtcaa ggaagtagcc gggcatggtg 2160

ccaggcacct gtaggaaaat ccag 2184

162

ggtgatgtgt cttcaggagt cccaatctat cttttcctgg tcctgggttt cagaaccgcc 60

tggggctgaa ccaaaatgcc cacagctccc atctctcctg gcctactgaa tatcagcccc 120

tgtgtcagtc ctcccagagg atagcctgag gagggtgtgg gatctcccaa aggagcaact 180

gaatttccca aatgggagga gactcctggt acactcttca tctagatagc caaccccttg 240

ggatgctcag cttttctttc ccagtcccag ttttcgtaag ttggagacac atggctggtc 300

agccagttgg atggtgctat tgagggaaag gagaaatgat tcctgtcctc tggattgtgt 360

caactgtgaa ggaagacaaa accccaaaag acaaggaaag cccaccccaa cggggtgnac 420

cagtagcctg caaatcagaa tatgaaattg aggttcacag cggggcatag tgcggtgttg 480

gtggaaagta gtcatgagcg cttcggtgag caggatgggg gtggagagat gtctcatgtg 540

atagggtgac ctgtgctgac acatgagtca gacatcactg tgttccagcc agtattgccc 600

ctctgtgggc ttgtcccttg taaagaattg ttcatagatt gcagcttgag tatttcaaat 660

taactttacg ttgcattttt cactagagcc aaatccaaga atgattgcat agatcaggta 720

agacacagaa gaggcaactc aacaaagccc atgacataca gtgcatggct cacaatccca 780

ggagatgagg gcagcacagc tgcagagcaa cacagagtgg ggagaacatc caggatgcac 840

attcaaccag caggtgggga gcaagacaga cagggacctg tgggccaaag cgtttctcag 900

ggtccaggga attgaacaag gagagatgtc tcatgtgaaa tgttcagaga atcaccacca 960

gacactcccg tgtgaaaatt tgtatgcatc tcctcctttc atctatccta gaaacagaga 1020

tctttttttt ttgagac 1037

163

ttttagagct acaaaatttt atagtttatg gaacatagca agtatatttc ctacaggatc 60

ttcatctgtg ttttcctttc agaactgtta agttttaaaa tgcagatggc ttcagtttct 120

tcttctgacg cctaagagag agaaaactag agagattaag agatccaagg tcactcatca 180

gacgtggaag aatccaggac tccaggcagt gtggggtctt ctattcacac tcacttcaca 240

ccttaatctc agttttacat ttcatcttct gttttcttta tacaatctgt ccagcttttg 300

aatataattt tccatacttt gagaagagct caaatgatgg taatacagtc tggaaatcct 360

tgtcacagat ccatttctta ggattttcac ttcggaattg ttctttgtaa gaaataggac 420

catacttgct tgataaatgc attgatggga tgtacttttc atttttatgg tatgaagaaa 480

atggcaaaaa catattgtca tttacatttt gcagccattc ctctcttctg agctcctctc 540

tggccaactt taactcatcg attggttctg ccacccgcaa cgttggctcc aaaggcctgt 600

agcgttgttc taatacttcg gtgatatctc ggaagggccc ctgacattgc tttctattaa 660

taggtggtag aatttcagac cgaggaaaag aacgggcgct tgtacaagct agccaatcag 720

taaggctggt ggagtccttc tgcttaactt taggtcttcg gtgtgttaaa ggctttgcct 780

tctgtaattg cagctcccat ggatcaggct cttttctgaa gggtgaattg tatattcctg 840

gaatctgctt tgtgctgagg caggtaatgc atctttcggg cttggtaatc tcttttcttc 900

tcttcccttt cgaggttagc cttcttctct tctctttctt tcatttctgc aaactcctcc 960

agtgccttcc tttggttgcc atgaacttgg a 991

164

cttcaacaaa ggacactaca tcaaggactg cccccaggca cgccccaaag gcgagggcct 60

gactccatac cagggcaaaa ancgctgctt cggcgagtac aagtgtccca agtgcaagag 120

aaaatggatg ngcggganct cctgggccaa catggggcag gagtgcatca agtgccacat 180

caacgtgtat ccacacaagc agagacccct ggagaagccc gacggnctgg acgtgtccga 240

ccagagcaag gagcacccgc agcacctctg cgaggaagtg caaggtcctg ggctactact 300

gccgtcgcgt gcagtgacgg gctgcctgcc cncacccaga gccanccccc gacagcccga 360

ggagacgctg cttccctgtg ctactccgag gggctgcgtg tcgccctgtg catggggtgc 420

cctcgcaggc ctgcggggct gggccggggg ctcttagcgt ccttgtcttg tgtgtgttga 480

caaacagtgt tactgacatt gctgcccccc acaggccagg gaaagcaggg agtctggggc 540

tttttgcagg cgggcctggg gtctcagtgg aggggacaaa ggcaagcaaa agcccatgtc 600

caggagccct gggtgtcccc acaggctcgc ctctgagagc ctctttgggg tgagcagcct 660

tgtattggcc acaggtgcac taaattgact gtgaatccca aacctcccca gaccagccag 720

gccgcctgcc cccacccaga accttccggt ttgccctgta tggaaagcca ctctcggaaa 780

tccctctttc ctgagtcagc aatcgtggca aggggacatg tgttccaaca gcggctgggg 840

agtggacctc tctgtccctt gcccacctta agccccaaat ccagaccccc tctgacatca 900

ctggcattgc acctgggtgt gcccccctcc ccacgctatg gacccagata ggaggggtta 960

ggcatggggg aggcacagaa tgctggagag atgcgtcctg gtgaacgtgg ggcagcccct 1020

cccacgaccc ccaccagact gccttaggtt ttgtcagccc cactcccttt ccttcccctc 1080

tgcctcccac ccactctggg ggtccacatc aagatagctg ggcccagtgt ggaagcccag 1140

cgtgtctgtt ctagcagaaa ggacacaagc ctggtgttct ggagannnnn nnnnnnnnnn 1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260

nnnnnnnnnn nnnnnnnnnn acagcataac actagagagc agagggccca tttcagctct 1320

gttgttctgg gattcaggct ggccggtgct gtgtcctgga gctttatttg gggagtttca 1380

cccagaatgg tgggagaaac ctcccaggtg ccaggtaccc cgcatcgtga cccttcactt 1440

ggtgtcttag gaagtcaagc tgagggatgc tgagtcctcc cctgctggcc cctgcagccc 1500

cagccctgct tttcatcccc cacccctgca aacatggagg agccccctcc ttctcacctc 1560

ggtctcctag cccctgacat ggagaaccct gagacaagcc acagaacccc tcttttctaa 1620

aatggagaca ataatttcct acctcccaag ggagcagaga ggcctcgtgg cacgtccgtg 1680

gccagggagc ccactgtcct ggctggcggc gggatcgtgc gctcctctgt ctcccggatg 1740

agaagccccg tttccatggt cttgaccctt cctttctccc ggctgtcaga actgggtctc 1800

ttgattttgc ccctacatta tgcctctgtg ggaaaaaaaa aaaatcagac caagaaatga 1860

gcctgaaatt cagtgtttac catggctcaa ggatgcccat ctggtgtcca gttgcctttt 1920

gtattcaaat gaaaatgctt tgtacaactg aggagttaca gtgaagtgtt aaccaggggt 1980

ccagggagcg agttgaaaag atggagtgag tgtatttgca gccagggagc tgcagggtgg 2040

atttgagggg ccataccctc tgagcactta acaaaggtat ttgctccagg ccaggcagca 2100

ggctgtggac acccttgcca ccactgggga ctgccactga ggactccccg agcacgttgt 2160

tccccgtctt ctccaaggtg ttgaggtgag ctggggttgg ccccggccca ggcttctgtc 2220

ccaaggagaa gctgccactg acagtcatcc taccgcactg ctaaagagaa tgttcgcagt 2280

ggtgggcggc gtgcctgtgc caacccttcc agggacccgg ccatggggga ccttggccca 2340

aggatgcctg gggcctgcca gctgtgctgc aaaggtgggg ggcccacacc ctaaaactaa 2400

cccaggcccc agaccactgg aggccagggc ttccctgcac gggctaaggg gagttgggat 2460

atcaccccaa agtgaccttg ccagtgagct gttcagcagg tagccactgc cctgccatct 2520

gtgcagagcc agccaccttg ggggctgggg ttcccgcttt gaggcccacc ttccatactc 2580

cccttgactc ggctctggct gaactgggga actctcttgt ggtcagcaaa gcccctgcca 2640

tgcaggccag gtgccattga gaattaagtg ctcagagggc caggagccca ggggatggga 2700

aagtgtgtgg ttttagtacg ttcaaaaggg acaatcgctt gcagttggta gatctagcga 2760

tctagttggg agataatggt gtttacccca tatgaagtat tcaatagttc tacttgtgaa 2820

tttgtattta ttttgagtta tacttgacac agaattcctt ttttaaaaaa atatgtgtgt 2880

attttggaaa aaaaattcat agatgttaaa atttctgcat ggttaccagt ttttctcaca 2940

acactgaatt tggtagcttt tcccgaaaaa atcttcacag taattttttg tctgtatata 3000

tttgagggcc ttttttaaan aaanaaanaa nncaagaaaa atataattgt ttgatttttg 3060

agattaaaac aaacaaaaag agaggcattt tcaaaatttc agaactttca ggagggcaag 3120

agaatatcaa acaaagattt ctggaagtat tttgccaacc ttctggttga gctgcaagaa 3180

aatatttatg gtgagaactt ttctgtttcc cgttattggg tttttggttg gtttttgttt 3240

gttttttact atgctttggt ctgtaaaaat atgcaactga actacattca gaaggaaata 3300

ttgtctacat agaatattat atgaagttgg tacataattc tgatgaggaa aaaaaatctt 3360

tgcaattctt taagccatat tgttgttttt ctgtgttgtt ttccctggat gaaaatatca 3420

gtattaagta gacagcatat tattcaagtg tttagactta ttaatatgtt cttgtccctg 3480

tatttataca tatgtgtatt ttggaaagta ttgccttttt taagggaagc tataattcga 3540

tacatagtga aaaagggaat ggtgacccct ttgtgcctct tccactgagg ataacaaaca 3600

gcattgtaat ccattctctt gcaccttctt cttcttatct tgttattacg gttttattaa 3660

ttttgtagag ggacagggag tgggcaaggg gaagaagcag cttatttgac taaccagccc 3720

ctctgtggtc caccagcgtc ttggcttggt gggagggctc tcaatcagca gggccccagg 3780

agggaagaag aagtggggca aagcctggcc tcgccgctcg ggagctttgc catctgagcc 3840

acgcctcctc caggccatgc tccttgaact tggaaatgtc aaccggagcc cttacaccag 3900

ccctccagca tctaatagac ttgaatctac tctaaacgaa tatttaatcc aacctcacta 3960

cattgtagct cagtccaacg actaaccctg aaatgggggt gttccagcct tcagcgagat 4020

ggccaagcgg tcccctgggg gctgtggcag cgggcttatc cttctctgtt gccaaccttg 4080

ccgtccgacc tcctccgccc ccatgcggtg accccgtccg tgtctgtgtc tgtccatacg 4140

tgtgagtcca gctaaaaaga caaaacagaa cccgtgggcc cagctcggaa ggtgcgtgga 4200

gaaggctccg acgtctccga agtgcagccc ttgggatggc attccgttgt gtgccttatt 4260

cctggagaat ctgtatacgg ctcgcctata gaaatatagc ctcttcatgc tgtattaaaa 4320

ggacttttaa aagcaaaaa 4339

165

cagccgagtt gctttcttac taaatcctat taaaatatgc aaaaataagt cagattttaa 60

ggcaaataaa gtgacataag gtgctttata ttttattttg gtatatttaa acagtgaaaa 120

actaactgaa agcacatgaa gagttgtaac ttgggggaaa ataggtaaac atagcttcta 180

gctaacacag gagacctatt cttagccttt actaatttca agcagtgtat cccatatggt 240

atctcttgct cttccttcaa ctccaataaa tttaatgact aaatgccaag ttaacaaatc 300

aacttccatt tggattgtag gtgtgaaggc acaactctaa ttgctattag tctacatgta 360

tttctgtaat agtattgtgt catatcaatt tttaagatgt ctaaatttta tggtcacaag 420

ttatccctcc tcagtatgaa aaataaatta gatattgaaa aatgtctaaa cttcagtgat 480

ggaaagaata tttcaagaag ttttttaacc taaatacttt tattttgaat ttaagtcttt 540

gcacataaaa tatagcaagc ttacatatta aactatttac gtaaatggaa tgtaagccat 600

gactttaact gaagtgttca cattcactaa ttttgataga ttgctgtcct taataatttt 660

ggaggaaatt aagccaaatg attattgtac tacagtattt tcagaatatg ggaaatcaat 720

taaaaatgta atctaatcta gtttaagatt tttgtttaat catcatggtg gtcctacctg 780

gataatttaa ctataaagac aaagtaattc tattaaatga actaactgaa aataataatt 840

ataggaagtg attattccat tttaagtatt agagctcaaa ttggctttat ttgcatttag 900

ggagatcatg ttttcttaat catgctggaa tttaaaaatt gttttacttg tatcgaaatt 960

aaccttgatt tataactatt tttgtaataa aacaatgaca gctgtagtaa ctatgatggg 1020

tgtaacaaca tttttttaaa gaagggaatc tgtttatcgc ttttcaaaat attttctaaa 1080

gtgggggaag aaagtttata gactttccaa gcacatttat ggttttttat tactattatt 1140

atggttttaa aaagagtaac tttatttctt tttgtaagga attaagtaat atcctttaca 1200

gttctgtgaa aggacttatt ttttaactgt aatatttatt agttttaaaa tatttgtatc 1260

tcatttgtaa caatttgttt taatttttta tatatatgtt tttattttta aaaaacatac 1320

cagttgaatg gggttaaagc tttcaatatc ttaaaatatt tataaaacat ttcactgttg 1380

caaaatcact tccaaaatga tagctatcta acaactaatt actaattttt aaagaacaaa 1440

tcacacattt aaaaaatctg tagaatttat tttaactatg acctttaatt gaaaataaat 1500

aattaaaata tcagacatgt tttggaaaag tcttaatttg agaacaccaa aggaaactac 1560

cccagaatct aatgtagttc gctattaata acaatgcatt attgaaagta tattgcaaat 1620

acatgtttcc tcatgaaatc taagtaattt tgttgtggaa tagtgtcact gttacatttc 1680

ccccatgaag ttcaataaac cagcttagcc acaaaaaaat tacttagatt tcatgaggaa 1740

acatgtattt gcaatatact ttcaataatg cattgttatt aatagctaac tacattagat 1800

tctggggtag tttcctttgg tgttctctaa ttaagacttt tccaaaacat gtctgatatt 1860

ttaattattt attttcaatt aaaggtcata gttaaaataa ataattncna atatcagaca 1920

tgttttggaa aagtcttaat ttgagaacac ccaaggaaac taccccagaa tctaatgtag 1980

ttagctatta ataacaatgc attattgana gtancctgca aatacatgtt tcctcatgaa 2040

atctaagtaa ttttgttgtg gaatagtgtc actgttactt tcccccatga agttcaataa 2100

accagcttag ccac 2114

166

ccaaggngct gggattacag atgtgggcca ccgtgcctgg ccagaaaatc tggattctta 60

ttcctagttc ttcatttctg tcacatgcac ttagttgaca ttacatctac atatattagc 120

tttttcctac atgagccatc tatttactta gtaaccagtg ttcttaatga agtatttagt 180

cttgggtttc ttgtaaaatt tctctgcatt ccttagacag tgtactatac atgaaatatt 240

cttgttgacc tagtaattta tattattcca tttaattctt aaacctatgg cctttttatt 300

gagcacactc ttaaatcatt atttggcttg taaacattca tctgaattgt ggctacaatc 360

ctctttaaat aatctaggaa aaaagaaaga taaagcttac attttcacag ttttggctct 420

taaacacatt ccacaaatgc cattaagaat ttattttgtt ttannnnnnn nnnnnnnnnn 480

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 540

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt 600

ttgttttaga gtcatttaat gtgtttttat gcacaataat agtgggaggt tgttttgttg 660

catttgtttg tttgttttgt tttgttttgt tttgctttcc atgtgggaaa agttaacatt 720

ggaactgttt ctagtaaaag atttttttca ggctgggcac ggt 763

167

aattcggcac gagcggggaa gcttcgcagg cgtgcacgga gcagtgagat cactggcgtt 60

ataaatatcc cggtgccagc gcggagatcc gtcgggtggc ctctctcttc ccctctcccc 120

ttctcttccc cgaggctatg tccacccggt gcggcgaggc gggcagagcc agaggcacgc 180

agccgcacag gggctacaga gcccagaatc agccctacaa gatgcactta ggacccccgc 240

ggctggaaga atgagcttgt ccttcctcct cctcctcttc ttcagccacc tgatcctcag 300

cgcctgggct cacggggaga agcgtctcgc ccccaaaggg caacccggac ccgctgccac 360

tgataggaac cctagaggct ccagcagcag acagagcagc agtagcgcta tgtcttcctc 420

ttctgcctcc tcctcccccg cagcttctct gggcagccaa ggaagtggct tggagcagag 480

cagtttccag tggagcccct cggggcgccg gaccggcagc ctctactgca gagtgggcat 540

cggtttccat ctgcagatct acccggatgg caaagtcaat ggatcccacg aagccaatat 600

gttaagtgtt ttggaaatat ttgctgtgtc tcaggggatt gtaggaatac gaggagtttt 660

cagcaacaaa tttttagcga tgtcaaaaaa aggaaaactc catgcaagtg ccaagttcac 720

agatgactgc aagttcaggg agcgttttca agaaaatagc tataatacct atgcctcagc 780

aatacataga actgaaaaaa cagggcggga gtggtatgtg gccctgaata aaagaggaaa 840

agccaaacga gggtgcagcc cccgggttaa accccagcat atctctaccc attttcttcc 900

aagattcaag cagtcggagc agccagaact ttctttcacg gttactgttc ctgaaaagaa 960

aaagccacct agccctatca agccaaagat tcccctttct gcacctcgga aaaataccaa 1020

ctcagtgaaa tacagactca agtttcgctt tggataatat taatcttggc cttgtgagaa 1080

accattcttt cccctcagga gtttctatag gtgtcttcag agttctgaag aaaaattact 1140

ggacacagct tcagctatac ttacactgta ttgaagtcac gtcatttgtt tcaatgtgac 1200

tgaaacaaaa tgttttttga taggaaggaa actg 1234

168

cccctgactg taagtggtgg gagagggagg ggagttaatg gaactgggtc tgggattatt 60

ttaaaattat atatntatat ataaagatan nnncttacat cttttctttg ccctctgtgc 120

tttgaaagca ctggataaat tgtttggttt tgcttttctc tcttccacaa aattggaagc 180

tttttttaaa aatgttttcc ccacaagtca tcttgccttg tggcatgtct gtctagcctc 240

ttcctccctc cctcatgatg aagtgccatt tctgttacgt ctccctctcc ccaagctcag 300

aggtgctcag aggtacgaga tacccaagtt tgtcagttga gattaaaagt aaggaacaga 360

gaatgtgcaa taccgtctgg ctgggggctg tccctgccct gccctgagct gagtcctttc 420

cctgggagcc aggccacctt agaatggggt ttggaagtaa gatgtataga gttggggaat 480

cattggagaa ggaaagccta tagtcgagtg cctgcttagg tgctgaggtc acaggggaga 540

tggtggaatc ttccctgttt ttatcccctc agggtcagtt acatagaagc tgcttcttga 600

ctagtatagc tcggtgaccc tttgttcaac cgctgaggtt tgatttctta ccctttcttc 660

tccccatttt catactcttc ccagggatta gtgatggagg tgaggtctcc ctaatcatgg 720

taaagtgtta accttccacc tcctcccttc cctcctcctt cctcatcctt ctgtcttcct 780

caattctccg tctctttttt ttcatcactg attgccttgt gtccctccaa gtctacttgt 840

tactatccat ctccaggctc tgggccgtgt agacactaaa cctcatgccc taaggacagg 900

aggaaagacc ctctgtttgg agcattatta gtagagtgag gatcccacca gttctgcctg 960

gcttcctcca tccccagagg cactaaaagc agtattttaa ggttggtgtc ttactccctg 1020

gaagcctgaa atgggtggaa tagcggtaag gcttgagtaa aactagggga cagaggttct 1080

tatttgtcga ttttatttta taatttgacc acagcatctg aactccctct ctccctggaa 1140

taagtatttt tcccacattt ttggatatat gtatggtaga caattttttt ttaagacaca 1200

gagataaacg ttttcctgct ttggttacct ttcctttccc ctttaaaagg aattagctat 1260

agaactgctt tgtaaagatg cttcttgata ttttactttt gttccttttc cctaatcatt 1320

cccttttctc cccactcctc cagaaggcat aacccttctc tccacaaccc ctacccccac 1380

ccccgtccta ggctcccatc ctttccatca agaccttcat tagcttatga tatttgctgc 1440

cgagatgtta taacaaggac tcgttcatgt atataagcta tttcttgatc catttaaaag 1500

gaattgtaca ttgtgtagaa aaaaaaaaaa acctgaaaaa gagaaaaaaa agccctggag 1560

tagtccctcc gggtcaccag cactgccttg gcagagccca ctccctaccc taacctgccc 1620

accctcccta tcccccagca ttaggttgat actgtgggga agtgctgggg gctgggaggt 1680

agccgaggaa tggggcagtt cccgggggca tcgaaaccaa gtattattat gaattgtaat 1740

tgtatttgca ctgttttttt cctctgattg catcagcata tatacaatat acctatataa 1800

caaaattcag tgtcaagctt tcttatgcaa gggatttccc ccaccccacc tcctcaaaaa 1860

agaaagaacc tagtcttatg ggcctttgag ggtggattgt caggggatga tagaaaggat 1920

tttaataagt catcctgagg aaatttcacc tagtgagagc cacatccatc tgcacagcct 1980

taggctgcgt gaaccgaggt gaggctgagc tcctgtgaaa gccaagacct cctggtccag 2040

gactttgtag gagtaaaaag aaccaccagc acanaagggg ttgagggggc tacaatctgg 2100

agacctgggg tctcctacta acttgctata tgatctttgg nagagttaat tttctgagta 2160

tcaattttct tatctgtgaa gtgaagaggg ggatcatctg gccaccaagt ttaaaattct 2220

atacttctca cctgccaaaa ccaaaaaaca acttgaggtg aggaaagtgt tgggcccaga 2280

aaccagggag gaactgaaag tgactcgcgt tgaagtggtt atgtgtatga caatgctctt 2340

ggagaactgc cagtcctcta tggttaccct tgatttggga gaggcagcag agtcatgtcc 2400

agggcatcag accagtgaca tctttgcctt tatgcctcta gtcatctgag ggcggggact 2460

aggcctcaag ccccatctca cagccaacca cagagccctt aagggtggtt gacaattgaa 2520

tgccccaggt tggtgcttta gttatttact ccctttgtga gctacaggat gtgtaacttt 2580

tcccccatct tggtgataaa ataggagagc gcagacacag cccacatttt gtctcctttc 2640

ctcagatttc atctgaaccc cgctaaaggc aagctgtttc acagtctgtc tccttcaggg 2700

gcccaatttc cccacagcct gggctgagta ctcctactct cttctttagg ttctgggctg 2760

ataaagcctg gagagggtac agggtgatgg gtgaagccct ggtgaaggtg aaaggataga 2820

ttggggttgg ggggtgggga gcagggaggt gggatgggga atggccttcc ctgaataggg 2880

tgggtgggag gggaacaaga cccttttgca caactctctt taagtttcct ttatttcttt 2940

tttaactcat tctgattttc tgcattgtgt ttgggaaata aaatgaaaaa actaagacca 3000

atagaaactg gttttcaaaa aggcaaatac actcccatct gtttcagatg ctgctgagca 3060

tttcagcagt gacagattca aataataagc taatttttgg agaaaggatt aaaagaaaaa 3120

aaaactttgt aatatttatc acttgcaagc tatgtttaat aaagaaagga atggtttcta 3180

aaaaaa 3186

169

cgcccctgca gcagagctga aaaaaaccag gatccgggtt cctcagcccc ttttcacaat 60

atttgattag gaatttgggg cgggaccctg gtctggcaca ggcacgcaca ctctcagtag 120

actctttcac tcctctctct cttcctctct cacacgttct ccaacccaag gaggccagac 180

agagggacgt ggtcactctc tgaaaagttc aacttgagag acaaaatgca gtggacctcc 240

ctcctgctgc tggcagggct cttctccctc tgcccaggcc cagtatgaag atgaccctca 300

ttggtggttc cactacctcc gcagccagca gtgccaccta ctacgatccc tatgaccctt 360

acccgtatga gacctacgag ccttacccct atggggtgga tgaagggcca gcctacacct 420

acggctcttc catcccctcc agatccccgc gactgccccc aggaatgcga ctgcccaccc 480

aacttcccca cggccatgta ctgtgacaat cgcaacctca agtacctgcc cttcgttccc 540

tcccgcatga agtatgtgta cttccagaac aaccagatca cctccatcca ggaaggcgtc 600

tttgacaatg ccacagggct gctctggatt gctctccacg gcaaccagat caccagtgat 660

aaggtgggca ggaaggtctt ctccaagctg aggcacctgg agaggctgta cctggaccac 720

aacaacctga cccggatgcc cggtcccctg cctcgatccc tgagagagct ccatctcgac 780

cacaaccaga tctcacgggt ccccaacaat gctctggagg ggctggagaa cctcacggcc 840

ttgtacctcc aacacaatga gatccaggaa gtgggcagtt ccatgagggg cctccggtca 900

ctgatcttgc tggacctgag ttataaccac cttcggaagg tgcctgatgg gctgccctca 960

gctcttgagc agctgtacat ggtgcacaac aatgtctaca ccgtccccga tagctacttc 1020

cggggggcgc ccaagctgct gtatgtgcgg ctgtcccaca acagtctaac caacaatggc 1080

ctggcctcca acaccttcaa ttccagcagc ctccttgagc tagacctctc ctacaaccag 1140

ctgcagaaga tccccccagt caacaccaac ctggagaacc tctacctcca aggcaatagg 1200

atcaatgagt tctccatcag cagcttctgc accgtggtgg acgtcgtgaa cttctccaag 1260

ctgcaggtgc tgcgcctgga cgggaacgag atcaagcgca gcgccatgcc tgccgacgcg 1320

cccctctgcc tgcgccttgc ccagcctcat cgagatctga gcagccctgg caccgggtac 1380

tgggcggaga gcccccgtgg catttggctt gatggtttgg tttggctttt gctggaaggt 1440

ccaggatgga ccatgtgaca gaagtccacg ggcaccctct gtagtcttct ttcctgtagg 1500

tggggttagg gggggcgatc agggacaggc agccttctgc tgaggacata ggcagaagct 1560

cactcttttc cagggacaga agtggtggta gatggaagga tccctggatg ttccaacccc 1620

ataaatctca cggctcttaa gttcttccca atgatctgag gtcatggaac ttcaaaagtg 1680

gcatgggcaa tagtatataa ccatactttt ctaacaatcc ctgggctgtc tgtgagcagc 1740

acttgacagc tctccctctg tgctggggct ggtcgtgcag ttactctggg ctcccatttg 1800

ttgcttctca aaatatacct cttgcccagc tgcctcttct gaaatccact tcacccactc 1860

cactttcctc cacagatgcc tcttctgtgc cttaagcaga gtcaggagac cccaaggcat 1920

tgtgagcatc tgcccagcaa cctgtggaga caacccacac tgtgtctgag ggtgaaagga 1980

caccaggagt cacttctata cctccctaac ctcacccctg gaaagccacc agattggagg 2040

tcaccagcat gatgataata ttcatgacct gatgtgggag gagacagcca acctcaggct 2100

tagatcaatg tatagggcta tattttggca gctgggtagc tctttgaagg tggataagac 2160

ttcagaagag gaaaggccag actttgctta ccatcagcat ctgcaatggg ccaaacacac 2220

ctgcaaattg gctgagttga gaaagcagcc ccagtagttc cattcttgcc cagcactttc 2280

tgcattccaa acagcatcct acctgggttt ttatccacaa aggtagcggc cacatggttt 2340

ttaaagtatg agaaacacag tttgtcctct ccttttatcc aagcaggaag attctatatc 2400

ctgatggtag agacagactc caggcagccc tggacttgct agcccaaaga aggaggatgt 2460

ggttaatctg tttcacctgg tttgtcctaa ggccatagtt aaaaagtacc agctctggct 2520

ggggtccgtg aagcccaggc caggcagcca aatcttgcct gtgctgggca tacaaccctc 2580

tgctttcaca tctctgagct atatcctcat tagtgaaggt ggcttttgct ttatagtttg 2640

gctggggagc acttaattct tcccatttca aaaggtaatg ttgcctgggg cttaacccac 2700

ctgccctttg ggcaaggttg ggacaaagcc atctgggcag tcaggggcaa ggactgttgg 2760

aggagagtta gcccaagtat aggctctgcc cagatgccat cacatccctg atactgtgta 2820

tgctttgaag caccttccct gagaagggaa gaggggatct ttggactacg ttcttggctc 2880

cagacctgga atccacaaaa gccaaaccag ctcatttcaa caaaggagct ccgatgtgag 2940

gggcaaggct gccccctgcc ccagggctct tcagaaagca tctgcatgtg aacaccatca 3000

tgcctttata aaggatcctt attacaggaa aagcatgagt ggtggctaac ctgaccaata 3060

aagttatttt atgattgcat cta 3083

170

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg

1 5 10 15

Glu Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly

20 25 30

Lys Arg Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala

35 40 45

Leu Arg Asp Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr

50 55 60

Pro Pro Gln Ile Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu

65 70 75

Leu Phe Val Glu Ala Val Glu Gln Asn Thr Leu Gln Glu Phe Leu

80 85 90

Lys Leu Ala

171

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu

1 5 10 15

Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe

20 25 30

Thr Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg

35 40 45

Lys Cys Ala Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr

50 55 60

Ser Arg Gly Ser Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys

65 70 75

Pro Thr Cys Arg His Glu Val Ile Met Asp Arg His Gly Val Tyr

80 85 90

Gly Leu Gln Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr

95 100 105

Lys Gln Glu Cys Ser Ser Arg Pro Leu Gln Lys Gly Ser His Pro

110 115 120

Met Cys Lys Glu His Glu Asp Glu Lys Ile Asn Ile Tyr Cys Leu

125 130 135

Thr Cys Glu Val Pro Thr Cys Ser Met Cys Lys Val Phe Gly Ile

140 145 150

His Lys Ala Cys Glu Val Ala Pro Leu Gln Ser Val Phe Gln Gly

155 160 165

Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met Leu Val Ala Gly

170 175 180

Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu Asp Ser Arg

185 190 195

Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu Leu Ser

200 205 210

Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys Ser

215 220 225

Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser

230 235 240

Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys

245 250 255

Ser Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro

260 265 270

Gly Gly Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser

275 280 285

Ile Val Glu Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln

290 295 300

Gly Phe Glu Asn Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile

305 310 315

Ala Asp Ala Leu Arg Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu

320 325 330

Glu Glu Phe Ile Glu Glu Glu Asp Gln Glu Glu Glu Glu Ser Thr

335 340 345

Glu Gly Lys Glu Glu Gly His Gln

172

Met Pro Gly Tyr Gly Lys Lys Asn Ala Gly Ile Tyr Val Arg Pro

1 5 10 15

Arg Leu Phe Ser Pro Tyr Val Glu Glu Ala Lys Ser Val Leu Asp

20 25 30

Glu Met Met Val Glu Gln Thr Val Leu Val Arg Leu Arg Met Val

35 40 45

Arg Met Ser Asn Val Pro Asp Thr Leu Tyr Met Val Asn Asn Ala

50 55 60

Val Pro Gln Cys Cys His Met Ile Ser His Gln Gln Ile Ser Ser

65 70 75

Asn Gln Ser Ser Pro Pro Ser Val Val Ala Asn Glu Ile Pro Val

80 85 90

Pro Arg Leu Leu Ile Met Lys Asp Met Val Arg Arg Leu Gln Glu

95 100 105

Leu Arg His Thr Glu Gln Val Gln Arg Ala Tyr Ala Leu Asn Cys

110 115 120

Gly Glu Gly Ala Thr Val Ser Tyr Glu Ile Gln Ile Arg Val Leu

125 130 135

Arg Glu Phe Gly Leu Ala Asp Ala Ala Ala Glu Leu Leu Gln Asn

140 145 150

Pro His Lys Phe Phe Pro Asp Glu Arg Phe Gly Asp Glu Ser Pro

155 160 165

Leu Leu Thr Met Arg Gln Pro Gly Arg Cys Arg Val Asn Ser Thr

170 175 180

Pro Pro Ala Glu Thr Met Phe Thr Asp Leu Asp Ser Phe Val Ala

185 190 195

Phe His Pro Pro Leu Pro Pro Pro Pro Pro Pro Tyr His Pro Pro

200 205 210

Ala Thr Pro Ile His Asn Gln Leu Lys Ala Gly Trp Lys Gln Arg

215 220 225

Pro Pro Ser Gln His Pro Ser Arg Ser Phe Ser Tyr Pro Cys Asn

230 235 240

His Ser Leu Phe His Ser Arg Thr Ala Pro Lys Ala Gly Pro Pro

245 250 255

Pro Val Tyr Leu Pro Ser Val Lys Ala Ala Pro Pro Asp Cys Thr

260 265 270

Ser Thr Ala Gly Leu Gly Arg Gln Thr Val Ala Ala Ala Ala Ala

275 280 285

Thr Thr Thr Ser Thr Ala Thr Ala Ala Ala Ala Ala Ala Ser Glu

290 295 300

Lys Gln Val Arg Thr Gln Pro Val Leu Asn Asp Leu Met Pro Asp

305 310 315

Ile Ala Val Gly Val Ser Thr Leu Ser Leu Lys Asp Arg Arg Leu

320 325 330

Pro Glu Leu Ala Val Asp Thr Glu Leu Ser Gln Ser Val Ser Glu

335 340 345

Ala Gly Pro Gly Pro Pro Gln His Leu Ser Cys Ile Pro Gln Arg

350 355 360

His Thr His Thr Ser Arg Lys Lys His Thr Leu Glu Gln Lys Thr

365 370 375

Asp Thr Arg Glu Asn Pro Gln Glu Tyr Pro Asp Phe Tyr Asp Phe

380 385 390

Ser Asn Ala Ala Cys Arg Pro Ser Thr Pro Ala Leu Ser Arg Arg

395 400 405

Thr Pro Ser Pro Ser Gln Gly Gly Tyr Phe Gly Pro Asp Leu Tyr

410 415 420

Ser His Asn Lys Ala Ser Pro Ser Gly Leu Lys Ser Ala Tyr Leu

425 430 435

Pro Gly Gln Thr Ser Pro Lys Lys Gln Glu Glu Ala Arg Arg Glu

440 445 450

Tyr Pro Leu Ser Pro Asp Gly His Leu His Arg Gln Lys Asn Glu

455 460 465

Pro Ile His Leu Asp Val Val Glu Gln Pro Pro Gln Arg Ser Asp

470 475 480

Phe Pro Leu Ala Ala Pro Glu Asn Ala Ser Thr Gly Pro Ala His

485 490 495

Val Arg Gly Arg Thr Ala Val Glu Thr Asp Leu Thr Phe Gly Leu

500 505 510

Thr Pro Asn Arg Pro Ser Leu Ser Ala Cys Ser Ser Glu Ala Pro

515 520 525

Glu Glu Arg Ser Gly Arg Arg Leu Ala Asp Ser Glu Ser Leu Gly

530 535 540

His Gly Ala Gln Arg Asn Thr Asp Leu Glu Arg Glu Asp Ser Ile

545 550 555

Ser Arg Gly Arg Arg Ser Pro Ser Lys Pro Asp Phe Leu Tyr Lys

560 565 570

Lys Ser Ala Leu