Plasmid DNA from Yersinia pestis

This invention was made with United States government support awarded by NIH Grant No. HG01428, Subcontract No. 144 FH33. The U.S. government has certain rights in this invention.

Not applicable.

Over the centuries, the bubonic plague (also known as the Black Death) has claimed the lives of millions of people. The disease is characterized by chills, fever, vomiting, diarrhea, painful swollen lymph nodes (buboes), blackening of the skin caused by ruptured blood vessels, and a very high mortality rate (up to 75% if left untreated). Treatment with antibiotics in the early stages of the infection is generally effective.

Bubonic plague is caused by the bacterium Yersinia pestis , which is transmitted to humans from rats or other rodents by fleas that feed on infected rodents and then bite humans. Reservoirs of the bacteria persist today, and attempts to eliminate wild rodent plague have proven ineffective. Occasional outbreaks of the deadly disease continue to occur, particularly in small towns, villages, and rural areas in developing countries.

While bacteria carry genetic material in their chromosomes, bacteria also often carry genetic material in loops of DNA called plasmids. Bacterial plasmids are nonessential, extrachromosomal genetic elements capable of autonomous replication. The genetic material in plasmids often encodes functions required for maintenance of the plasmid in its bacterial host and sometimes encodes optional functions that promote survival of the bacterial host under certain environmental conditions. Pathogenicity determinants are commonly plasmid-encoded, and fall within the category of optional plasmid-encoded functions.

Yersinia pestis is a facultative intracellular parasite which harbors at least three different plasmids, designated pCD1, pPCP1, and pMT1, which are necessary for full virulence of the organism. One of the plasmids, designated pCD1, is also found in the enteropathogenic species Yersinia pseudotuberculosis and Yersinia enterocolitica (Ferber, et al. Infect. Immun . 31:839-841, 1981; Portnoy, et al. Curr. Topics Microbiol. Immunol . 118:29-51, 1985), whereas pMT1 and pPCP1 are unique to Y. pestis (Brubaker. Clinical Microbiol Rev . 4:309-324, 1991). Plasmids pMT1 and pPCP1 are thought to promote deep tissue penetration by Y. pestis and to contribute to the acute infection associated with this species. The Y. pestis genome shares much homology with that of Y. pseudotuberculosis , (Bercovier, et al. Curr. Microbiol . 4:225-229, 1980; Moore, et al. Inter. J. Sys. Bacteriol . 25:336-339, 1975), yet the infection caused by the latter organism is usually mild and self limiting (Butler, Plague and other yersinia infections, p. 111-159. In W. B. Greenbugh III and T. C. Merigan (eds.), Current topics in infectious disease, Plenum Press, New York, N.Y., 1983).

An understanding of the differences in the pathogenesis of Y. pestis and Y. pseudotuberculosis may be afforded by comparing polynucleotide sequences or genes found on pMT1 or pPCP1 plasmids, and which are unique to Y. pestis . It has been found that Y. pestis strains lacking the pCD1 plasmid are completely avirulent. Therefore, determination of the complete pCD1 sequence may provide important information about the role of the plasmid in virulence in various pathogenic yersiniae.

The 9.5 kb plasmid pPCP1 encodes a bacteriocin termed pesticin, a pesticin immunity protein and a plasminogen activator activity. Loss of this plasmid increases the LD 50 of the organism by a factor of one hundred thousand, as measured by subcutaneous injection in the mouse model. (Sodeinde, et al. Science 258:1004-1007, 1992).

The second plasmid unique to Yersinia pestis , designated pMT1, is a 100 kb plasmid that encodes the capsular protein Fraction 1 and the murine toxin (Protsenko, et al. Genetika 19:1081-1090, 1983). The genes for the capsular proteins have been cloned and sequenced using Y. pestis strain EV76 (Galyov, et al. FEBS Lett . 277:230-232, 1990; Galyov, et al. 286:79-82, 199.1; Karlyshev et al. FEBS Lett . 305:37-40, 1992). The role of these proteins in plague pathogenesis has not been unequivocally determined, and the effect of mutational loss of these proteins on the LD 50 varies, depending on the animal model and route of infection (Brubaker Curr. Top. Microbiol . 57:111-118, 1972; Brubaker Rev. Infect. Diis. 5: S748-S758, 1983). However, pMT1 does appear to contribute to the acute phase of plague infection, as evidenced by a reduced morbidity associated with infection by strains lacking pMT1 (Drozdov, et al. J. Med. Microbiol . 42:264-268, 1995; Samoilova, et al. J. Med. Microbiol . 45:44.0-444, 1996;Welkos, et al. Contrib. Microbiol. Immunol . 13:229-305, 1995).

Information pertaining to the genetic characterization of the pMT1 molecule is limited. The size of the plasmid has been found to vary, either from variations in the versions of the plasmids or in technique to measure the plasmids, from 90 kb to 288 kb (Filippov, et al. FEMS Microbiol. Lett . 67:45-48, 1990). It is known that pMT1 is an integrative plasmid capable of integrating into Y. pestis chromosome with high frequency and at multiple sites, with integration likely resulting from IS100 homology between the plasmid and chromosome (Protsenko, et al. Microbiol. Pathogen 11:123-128, 1991).

Previous characterization of pMT1 has identified five genes that may be involved in the synthesis of murine toxin (MT) and F1 capsule antigen, both known virulence factors. Expression of both the capsular protein and murine toxin genes has been characterized with respect to environmental cues (e.g., temperature and-calcium) (Du, et al. Contrib. Microbial. Immunol . 13:321-324, 1995). F1 capsule synthesis is maximal at 37° C. in the absence of extracellular calcium, conditions similar to those that induce expression of a major Y. pestis virulence determinant (Straley Rev. Infect. Dis . 10:S323-S326, 1988; Straley Microbial. Pathoaen 10:87-89, 1991; Straley et al. Proc. Natl. Acad. Sci. USA 78:1224-1228, 1981). Murine toxin expression is induced at 26° C., conditions similar to those that would be expected to occur in the flea vector. The occurrence of plasmid genes that are induced under widely different conditions suggests regulation of Y. pestis virulence determinant expression by at least two networks.

The plasmid pCD1 is found in Y. pestis , as well as in certain other pathogenic Yersinia species, including Y. pseudotuberculosis and Y. enterocolitica . The plasmid encodes a complex virulence property called the low-Ca 2+ response (LCR). The LCR was discovered in Y. pestis growing in vitro, where the bacteria respond to the absence of Ca 2+ at 37° C. by the strong expression and secretion of a virulence protein called V antigen, or LcrV. In certain media, expression of LcrV is accompanied by a response termed “restriction,” in which the yersiniae undergo an orderly metabolic shutdown and cease growth. Under LCR-inductive conditions, the transcription, translation, and secretion of a set of virulence proteins called Yops (for Y ersinia o uter p rotein s ) is maximally induced. The operons encoding these and other similarly regulated operons on the LCR plasmid have been referred to as the LCR stimulon (LCRS). Millimolar concentrations of Ca 2+ permit full growth at 37° C., reduced expression of LcrV and Yops, and essentially no secretion of these proteins. Under ambient temperature conditions outside a mammalian host, the Yops and LcrV proteins are produced at a low, basal level and are not secreted, which suggests that the LCR is designed to function within a mammal. Expression of LCR is apparently modulated by other environmental factors, including Mg 2+ , Cl − , Na + , glutamate, nucleotides, and anaerobiosity. The molecular basis for these effects has not been determined, but these elements of environmental modulation could be important in adjusting virulence protein expression and secretion in response to the wide range of niches that yersiniae are expected to encounter during an infection.

The pCD1 plasmid also encodes a type III secretion system called Ysc (for Y op s e c retion) that is involved in the secretion of Yops, LcrV, and some regulatory proteins in the LCR. The Ysc system is locally activated by cell contact at the interface between a bacterium and eukaryotic cell. This cell to cell contact causes the opening of the secretion system's inner and outer gates (LcrG and LcrE (or YopN), respectively), thereby allowing secretion of negative regulatory proteins (e.g., LcrQ also called YscM, a key regulatory protein). Secretion of negative regulatory proteins allows full transcriptional activation of LCRS operons by LcrF, an AraC-like activator protein.

Yops are secreted locally, without processing. The secretion mechanism recognizes two signals: one in the first 45 nucleotides of the yop mRNA and one related to a domain that has been found for some Yops to bind a specific Yop chaperone (Syc), also encoded by the LCR plasmid Certain of the Yops (e.g., YopB, YopD, YopK) are involved in targeting effector Yops (YopE, YopH, YpkA, YopM, and possibly YopJ) into the eukaryotic cell. Once inside the cell, the effector Yops act on intracellular target molecules, thereby interfering with cellular signaling and cytoskeletal functions. LcrV acts functions both as a regulatory protein involved in Yop secretion and targeting and as a potent anti-host protein. LcrV is the only LCRS protein that is secreted in large amounts into the surrounding medium by yersiniae in contact with eukaryotic cells. LcrV adversely affects the host organism when administered alone to mice, whereas all other secreted proteins depend on the Ysc machinery of yersiniae, in intimate contact with mammalian cells, for delivery into the mammalian cells.

Expression of the LCR has a profound immunosuppressive effect that results from the interference with innate defenses at the site of infection and the host organism's inability to mobilize an effective cell-mediated immune response. Y. pestis , and, in immunocompromised individuals, the enteropathogenic yersiniae grow unchecked in the lymphoid system in a fulminant-disease associated with high mortality, absent appropriate antibiotic treatment. In contrast, yersiniae lacking the LCR plasmid pCD1 are completely avirulent.

Several other important pathogens have virulence systems with many striking similarities to the LCR; however, the LCR is the best characterized of these and remains a prototype for investigations at the forefront of molecular pathogenesis.

A more complete understanding of the role of LCR plasmids may be obtained by determining the entire sequence of an LCR plasmid.

The development of additional sequence information from plasmids of Y. pestis is needed for comprehensive efforts in the detection, diagnosis, prophylaxis and treatment of infections caused by the organism.

One aspect of the present invention is an isolated Yersinia pestis plasmid pMT1- or pCD1-specific polynucleotide sequence selected from the group consisting of any portions of the sequences present in SEQ ID NO:1 through SEQ ID NO:6 set forth below.

The present invention is in part summarized by the presentation of the complete nucleotide sequence of two plasmids from Yersinis pestis , which enables diagnostic, prophylactic and therapeutic tools to be developed for use in combating the pathogen.

The DNA sequences of the present invention may include an open reading frame (ORF), an insertion sequence element, or a plasmid maintenance function, for example.

It is an object of the invention to provide essentially the entire sequence of pMT1 and pCD1 from Yersinia pestis KIM5 to allow methods of detecting, diagnosing, preventing, and treating infections with Yersinia pestis.

Other object, advantages and features of the present invention will become apparent from the following specification when taken in conjunction with the following drawings.

FIG. 1 is a plasmid map of the plasmid pMT1, showing in schematic fashion the relative positions of notable features of the plasmid.

FIG. 2 is a similar plasmid map of the plasmid pCD1.

This specification describes the complete DNA sequencing of the plasmids , pPCP1, pMT1 and pCD1 from Yersinia pestis , all of which are associated with the pathogenicity of the organism. Presented below is both the complete DNA sequence of the plasmids as well as tables listing the open reading frames (ORFs) of the plasmids, indicating which portions of the plasmid DNA encodes the production of proteins. Some other important regions of the plasmid DNA, such-as the integration sequences (IS) are also indicated. With the information provided by this complete DNA sequence information, several things become possible. It now becomes possible to design and implement nucleotide-sequence based diagnostic tools to diagnose and identify virulent strains of Yersinia pestis in a biological sample based on the presence of DNA sequence in such a sample. The identification of the ORFs contained in the plasmids makes possible the comprehensive identification and characterization of the toxins and other proteins encoded by the plasmids thereby enabling the ability to make antibody and other molecular forms of prophylactic and therapeutic treatment for the pathogen. This information also allows identification of new potential virulence factors that may be useful in the development of vaccines, or which may be suitable targets for therapeutic drugs. In addition, the sequencing data provides information about maintenance functions, horizontal gene transfer, conjugation, integration, insertion sequence (IS) elements, and evolution of these plasmids. The sequences from pCD1 and pMT1, and their significance, were first published by the inventors here in Lindler et al. Inf. Immunity 66:5731-5742, 1998 and Perry et al. Inf. Immunity 66:4611-4623, 1998, both of which are incorporated herein by reference in their entirety. Identification of maintenance functions provides information that is useful in designing cloning vectors, which can be used, for example, to study factors associated with pathogenicity.

Briefly, as described below in the examples, we determined the entire nucleotide sequence of the plasmid pMT1 from Y. pestis strain KIM5. We then analyzed the sequence and identified potential open reading frames (ORFs) encoded by the 100,990 bp pMT1 molecule. The complete sequence is set contained in SEQ ID NO 2 below. Based on yersinial codon usage for known yersinial genes, homology with known proteins in the databases and potential ribosome binding sites, it was determined that 115 of the potential ORFs likely encode proteins in Y. pestis . Seven new potential virulence factors that might interact with the mammalian host or flea vector were identified. The deduced amino acid sequences for 43 of the remaining 115 putative ORFs display no significant homology to proteins in the current databases. Furthermore, DNA sequence analysis allowed the determination of the putative replication and partitioning regions of pMT1.

A single 2,450 bp region within pMT1 that may function as the origin of replication (ori) was identified. The identification of this putative ori may allow construction of cloning vectors capable of replicating in Yersinia species. Such vectors will facilitate further research into the pathogenicity of these bacteria. The putative ori includes a RepA-like protein similar to those of the RepFIB, RepHI1B, P1 and P7 replicons. A plasmid partitioning function is located about 36 kilobases from the putative origin of replication and is most similar to the parABS bacteriophage P1 and P7 system. Y. pestis pMT1 encodes potential genes with a high degree of similarity to a wide variety of organisms, plasmids and bacteriophage. Accordingly, our analysis of pMT1 DNA sequence suggests the mosaic nature of this large bacterial virulence plasmid and provides insight into its evolution. The MT- and F1 encoding regions of pMT1 are surrounded by remnants of multiple transposition events and bacteriophage, respectively, suggesting horizontal gene transfer of these virulence factors.

The pCD1 sequence is 70,509 base pairs, and is presented as SEQ ID NO:1 herein. The SEQ ID NO:1 is actually 70,559 base pairs in length since it incorporates a 50 base pair repeat at each end of the linear representation of the circular plasmid. Sequencing of pCD1 has revealed a potential new Yop and Yop chaperone, two new IS, a set of LCRS genes very similar to those sequenced in the enteropathogenic yersinae, the IncFIIA replication region, and SopABC partitioning functions. Remnants of IS elements were found to be scattered throughout the plasmid, which suggests that pCD1 has undergone numerous insertional events as well as genetic recombinations and rearrangements during its history.

Yersinia pestis has an unique 9.5 kb plasmid, designated pPCP1, which contains genes encoding plasminogen activator/coagulase and pesticin. The total length of pPCP1 is 9,610 bp with a GC of 43%. The plasmid pPCP1 contains a copy of IS100. Three known gene functions located on this plasmid are as follows: 1) plasminogen activator and coagulase activity that is encoded on the same gene (pla), 2) pesticin, a toxin that inhibits growth of closely related bacteria, and 3) pesticin immunity gene whose product protects the bacteria from toxic effects of the pesticin. The origin of replication of pPCP1 is encoded on 780 bp region which is very similar to the origin of replication and the immunity region of Escherichia coli ColE1 plasmid. Loss of this plasmid leads to ineffective infection in guinea pigs and mice suggesting that the plasmid plays an important role in the invasion and infection of its mammalian host. The plasmid pPCP1 has also been sequenced and its sequence is presented as SEQ ID NO:3.

The sequences presented here are accurate to the best capabilities of the current state of the art, but may contain some minor errors, deletions, insertions or substitutions. It is also understood and expected that other strains of the host organism will have allelic variations of the genes in the host and therefore may carry different forms of the genes set forth in the sequence listing here. However, those of skill in the art expect such minor variations, and such minor sequence variations in Yersinia pestis -specific nucleotide sequences associated with nucleotide additions, deletions, and mutations, whether naturally occurring or introduced in vitro, would not interfere with the usefulness of these sequences in the detection of Yersinia pestis , in preventing Yersinia infection, and in methods for treating Yersinia pestis infection. Therefore, the scope of the present invention is intended to encompass such variations in the claimed sequences.

A Yersinia pestis -specific nucleotide probe is a sequence that is able to hybridize to Yersinia pestis target DNA present in a sample containing Yersinia pestis under suitable hybridization conditions, and which does not hybridize with DNA from other Yersinia species or from other bacterial species. It is well within the ability of one skilled in the art to determine suitable hybridization conditions based on probe length, G+C content, and the degree of stringency required for a particular application.

The probe may be RNA or DNA. Depending on the detection means employed, the probe may be unlabeled, radiolabeled, or labeled with a dye. The probe may be hybridized with a sample that has been immobilized on a solid support such as nitrocellulose or a nylon membrane, or the probe may be immobilized on a solid support, such as a silicon chip.

The sample to be tested for presence or absence of Yersinia pestis DNA may include blood, urine, feces, or other materials from a human, rodent, or flea susceptible to infection by yersinia pestis . The sample may be tested directly, or may be treated in some manner prior to testing. For example, the sample may be subjected to PCR amplification using appropriate oligonucleotide primers. To have reasonable assurance of success under conditions of variable stringency, it is preferred that such diagnostic probes uses sequences which are at least 15 nucleotides or longer in length. While probes as short as 15 base pairs can be made to work, probes of at least 25 base pairs or longer are preferred. Any means of detecting DNA-RNA or DNA-DNA hybridization known to the art may be used in the present invention. Since the plasmids set forth below are diagnostic of pathogen strains of Yersinia pestis , any set of 25-mers or longer from the sequences set forth below may usefully be employed as diagnostic probes for the presence of this pathogen in a biological sample.

Any and all of the ORFs presented here are of particular utility. Since these ORFs contain the coding regions for the proteins expressed by these plasmids, these ORFs are not just useful for diagnosis of the presence of the pathogenic host, they may be used to express the encoded proteins in other hosts. Placing the coding regions of-the ORFs under the control of non-native promoters permits the expression of the proteins encoded by the ORFs in other hosts. The ORFs can be inserted into any known expression vector adapted for a particular host and then can be transformed into that host for expression to produce proteins. Such proteins can be used for both prophylactic and therapeutic purposes. The proteins can be used to generate antibodies to the proteins natively produced by the Y. pestis , the provide pathogen specific. antibodies for diagnostic or therapeutic purposes. Proteins, or even peptides from the proteins have potential for targets for vaccination studies.

Isolation of pMT1 DNA

Y. pestis KIM10+ (Perry, et al. J. Bacteriol . 172:5929-5937, 1990), a strain that contains only pMT1, was grown in Heart Infusion Broth (Difco Laboratories, Detroit, Mich.) at 26-30° C. Plasmid DNA was isolated from the bacteria using alkaline lysis and polyethylene glycol precipitation (Birnboim, et al. Nucleic Acids Res . 7:1513-1523, 1979; Humphreys, et al. Biochim. Biophys. Acta 383:457-463, 1975). DNA libraries were prepared from purified pMT1, as described below.

Isolation of pCD1 DNA

Y. pestis strain KIM5 is conditionally avirulent due to deletion of the 102 kb pgm locus; it possesses all three prototypical Y. pestis plasmids (pPCP1, pCD1, and pMT1). Plasmid DNA was isolated from Y. pestis KIM5 by alkaline lysis followed by precipitation with polyethylene glycol. A mixture of pCD1 and pBR322 was transformed into Escherichia coli HB101. Transformants containing pBR322 were selected on the basis of ampicillin resistance. Ampicillin resistant transformants were transferred to nitrocellulose membranes and hybridized against pCD1 radioactively-labeled by nick translation, which allowed identification of cotransformants containing both pCD1 and pBR322. A selected cotransformant was cured of pBR322 by fusaric acid selection and used for isolation of pCD1. The pCD1 plasmid appears to be stably maintained in E. coli HB101. Plasmid DNA from E. coli HB101 (pCD1) cells grown in Luria broth was isolated by alkaline lysis followed by further purification with polyethylene glycol. Purified pCD1 DNA was used in subsequent sequencing.

pPCP1

DNA of pPCP1 was isolated for sequencing in a similar fashion.

DNA Sequencing.

DNA libraries of pPCP1, pCD1 or MT1 were prepared from nebulized, size fractionated plasmid DNA (Millon, et al. Gene, submitted) in the M13 Janus vector (Burland, et al. Nucleic Acids Res. 21:33.85-3390, 1995). DNA templates were purified from random library clones (Romantschuk, et al. Mol. Microbiol. 5:617-622, 1991), and DNA sequencing was preformed using dye-terminator labeled fluorescent cycle sequencing Prism reagents and ABI377 automated sequencers (Applied Biosystem Division of Perkin-Elmer). Sequences were assembled into segments of DNA sequence, referred to as contigs, by the SeqMan II program (DNASTAR), and clones were selected for sequencing from the opposite end to fill in coverage, resolve ambiguities and close gaps. Final coverage was about eight fold. The complete sequences of ball three plasmids are set forth in SEQ ID NO: 1 through 3 below.

In several instances,. pCD1 sequences differed from previously published sequences from the yersiniae or yielded unexpected results. To ensure that this did not result from mutations to pCD1 during carriage in E. coli , we sequenced these regions using pCD1 isolated from the conditionally virulent Y. pestis strain KIMS or pJIT7, a recombinant plasmid containing the IS1616 region adjacent to sopAB.

Sequence Annotation.

Open reading frames (ORFs) putatively encoding polypeptides at least 50 aa in length were identified using Geneplot or GeneQuest (DNASTAR) programs to display start codons (including GUG), stop codons and codon usage statistics plots for each reading frame. Codon usage analysis, used to predict ORFs, was assessed in the program by second and third order statistical comparisons with a matrix built from all available sequences for Yersinia species (Borodovsky, et al. Computational Chemistry 17:123-133, 1993). Although this matrix was more useful than one derived from E. coli genes, it was necessarily constructed from a relatively small data set. Generally, the start codon (including GTG and TTG) farthest upstream was used to annotate the ORF start. An ORF having fewer than 150 bases was included if it had a high codon usage score. For the first pass, putative amino acid sequences were searched against SWISS-PROT 34 using the BLOSUM26 matrix, by the DeCypher II System (TimeLogic Inc., Incline Village, Nev.).

Subsequent searches of the Swiss Protein, E. coli and non-redundant GenBank databases were obtained over the Internet using BLAST software (Altschul, et al., Nucleic Acids Res . 25:3389-3402, 1997) from the National Center for Biotechnology Information homepage (which can be found on the world wide web under ncbi.nlm.gov/BLAST). Pairwise protein alignments were with the BLAST algorithm. Protein localization was predicted for relevant translated orfs using the PSORT program (Nakai, et al. Proteins: Structure, Function, and Genetics 11:95-110, 1991). The prediction of membrane associated helices was with the TMpred program (Hoffman, et al. Biol. Chem . 347:166-172, 1993). Where appropriate, multiple protein sequences were aligned using the algorithm developed by Lipman et. al.(Proc. Natl. Acad. Sci. USA 86:4412-4415, 1989). These programs can be found as part of Pedros Molecular Biology Tools at Internet site www.iastate.edu.

Bank Accession Number

The annotated sequence for pMT1 and pCD1 were deposited in GenBank under accession numbers AF074611 and AF074612, respectively. These deposited sequences are also hereby incorporated by reference.

Sequence of pMT1

The fully-assembled pMT1 DNA sequence is a circular DNA sequence 100,990 bp in length. A map of the plasmid is set forth in FIG. 1, which illustrated the general location of sequences of interest. The complete DNA sequence of the plasmid is presented here as SEQ ID NO:2. Screening of the entire plasmid sequence using the DNASTAR program GeneQuest revealed 145 potential open reading frames (ORFs) along the entire length of the plasmid. The putative amino acid sequence of each ORF was used to search the various databases (GenBank, Swiss Protein,GenPept and E. coli ) for proteins with potentially significant homologies. Table 1, set forth below, identified the location and other information of interest about many of the ORFs which were found to have homologies to known sequences.

In the above Table 1, the location of each of the ORFs is given in base pair number corresponding to the entire 100,990 base pairs of the entire plasmid. ORFs listed were assigned a putative function according to our criteria outlined in the general overview section of the results and discussion. Classification then was based on these putative functions.

If there was insufficient homology, by our criteria, with known proteins in the database the ORF has not been assigned a function in the table. In evaluating the significance of potential matches, several factors were considered. In general, if the putative translation product of a pMT1 ORF exhibits significant similarity to known proteins in the database, the putative protein was assigned a similar function. Homologies were considered to be significant if at least 25 percent of amino acids were identical over at least 35 percent of the protein in the database. The 25% identity was chosen to give a reasonable baseline, with adjustments being made for conservative amino acid substitutions to give higher similarity scores between protein molecules.

In specific instances, we have designated a protein function as “similar” based on less than 25 percent identity. The extent of homology with the database protein was set at 35 percent to allow for the possibility that protein domains might have different functions in different molecular contexts. The stringency was lowered when deciding if a putative protein might function in pathogenesis. In these cases, if the region of homology included at least 20 percent identical amino acids with a protein that might interact with or substitute for the action of a host protein, it was considered a potential virulence factor. Greater weight was given to potential alignments if the homology between the Y. pestis ORF and the target protein sequence was in a domain having a known function in host physiology. Finally, if the putative protein does not contain significant similarity to any known proteins, the upstream DNA was analyzed for ribosome binding sites (RBS) and the known codon usage for Yersinia genes was considered. After applying these criteria to the 145 potential ORFs initially identified on pMT1, 30 were eliminated and 115 putative coding regions remained. Of these 115 putative ORFs, 38 percent had no significant regions of homology to any protein in the current databases and seven percent had significant homology with previously described hypothetical proteins.

Newly Identified Virulence Factors of pMT1

Because Y. pestis is a facultative intracellular parasite and pMT1 is thought to enhance deep tissue spread of the organism, several ORFs having limited homology with proteins that may function during various stages of the plague life cycle were carefully examined. The ORFs include ORF 4 (base pairs 76,298 to 76,603), ORF 17 (bases 92,476-92,919), ORF 18 (complement to bases 92,949-93,512), ORF 21 (bases 94,015-94,448), ORF 72 (23,873-24,244), and-ORF 74a (25,221-25,883). Again, all base pairs locations refer to the complete 100,990 sequence. Additional information about these identified virulence factors is presented in Table 2, below. Although many of these homologies are below our criteria for general ORF homologies, a more relaxed standard was indicated to aid in future research relating to plague pathogenesis.

In addition, one potential new IS element, designated IS1618, is located from bp 52,465 to 53,758 (or bases 2365-3658). This sequence, the boundaries of which are defined by two directly repeated sequences (GATGATAA), flanks a putative transposase designated ORF102. ORF102 had the greatest identity with a putative transposase previously found in Enterobacter aerogenases (Smith, et al. J. Gen. Microbiol . 139:1761-1766, 1993)(40% over 96 percent of the target protein) and a putative transposase previously described in Yersinia enterocolitica (Rakin et al. FEMS Microbiol. Lett . 129:287-292, 1995) (36% identity over 96% of the target protein).

The nucleotide sequence of Y. pestis pMT1 has provided a wealth of new information. Our analysis has allowed us to identify several genes to target for further study in order to access their possible role in pathogenesis. Deciphering the potential role of these proteins improves our understanding of disease as well as host physiology. As more complete virulence plasmid DNA sequences become available, we will begin to understand the mosaic nature of these molecules and what new combinations we might expect in the future. Detailed molecular analysis of the structure of virulence plasmids will impact our ability to predict the emergence of bacterial pathogens as well as detect their presence.

Sequences of pCD1

A genetic map of the Y. pestis KIM5 pCD1 plasmid, which is 70,509 nucleotides in length, is shown in FIG. 2 . Again the complete DNA sequence of the plasmid is contained in the sequence listing appended hereto, this sequence being SEQ ID NO:1. Again the ORFs of the sequence was determined by computer analysis and searched against existing data bases. Table 3 below lists significant ORFs and their primary characteristics. Most IS element remnants and partial ORFs that appear to be nonfunctional due to IS-related events or other deletions and rearrangements are not included in Table 3.

New Potential Virulence-related ORFs

Fourteen ORFs are not obviously associated with IS elements and either have no significant similarity to proteins in the database with known functions or have features suggesting a virulence-related role. These are ORFs that deserve future study as potentially having virulence or virulence-accessory functions.

ORF75 (Table 3) lies just 1 bp downstream of yopE and lacks an obvious ribosome binding site or upstream promoter. The ORF could encode an 11,192 Da protein with at least one likely transmembrane domain and a noncleavable signal sequence. Its expression conceivably is translationally coupled to that of yopE suggesting that it could be a member of the LCR. yopE has been called monocistronic, based on its estimated transcript size (750 bases in Y. pseudotuberculosis ). The presence of this ORF has not been noted in the literature, even though the beginning of Orf75 is present in the sequences previously submitted for Y. pseudotuberculosis yopE , Y. enterocolitica 0:9 and Y. pestis EV76 . Interestingly, it is intact but separated from yopE by an insertion element in Y. enterocolitica 0:8 strain 8081 . At high doses, a Y. pseudotuberculosis mutant containing an insertion in this ORF did not cause loss of virulence in mice infected orally (Forsberg, et al. J. bacteriol . 172:1547-1555, 1990). Given that YopE's importance in virulence was determined with polar insertion mutants, the significance of this ORF needs to be thoroughly tested.

While assembling this data, we learned that two new ORFs we found in Y. pestis have been designated as YopT and SycT in Y. enterocolitica (Miller, et al. J. bacteriol . 172:1062-1069, 1991). sycT and yopT are arranged in what appears to be a bicistronic operon upstream 500 bp and on the opposite strand from yopK (FIG. 2 ). These genes indeed have properties suggestive of a Yop and associated Syc. sycT is predicted to encode an acidic 15.42 kDa peripheral protein (Table 3). The database search brought up weak homology with SycE (with which there is 22% identity). Alignment of SycT with SycE, LcrH (SycD), and SycH shows the greatest similarity toward the C termini of the proteins, as previously demonstrated in a comparison of SycE and LcrH/SycD . YopT is predicted to be a peripheral 36.31 kDa basic protein (Table 3). It shows 36.7% identity in residues 98-322 with the C-terminus (residues 648-874) of a surface antigen in Haemophilus somnus that is associated with serum-resistance . The regulation, mechanism of action, and role in plague of YopT should be investigated.

ORFs 42, 43 and 44 (Table 3), located immediately downstream of tyeA (FIG. 2 ), have been noted to exist in Y. enterocolitica (Winans et al. J. bacteriol . 154:117-1125, 1083). ORF42 has been sequenced in Y. pseudotuberculosis and a polar insertion near its 3′ end caused a calcium-independent growth phenotype (Forsberg, et al. Mol. Microbiol . 2:121-133, .1988), typical of mutations in genes necessary for the functioning of the type III secretion system. Because this mutation was complemented by DNA lacking a complete lcrD/yscV gene (downstream of ORF44), the phenotype is not likely to be caused by disruption of lcrD/yscV. This, taken together with their location (within the LCR cluster and downstream of tyeA, which is involved in Yop secretion control), suggests that one or more of the ORFs 42 through 44 have a role in secretion or secretion control.

ORF5 (Table 3) is isolated from other virulence-related genes, within a gap between the origin region and an IS1236 remnant. It is presently unknown whether the sequence. encodes a virulence-related factor.

ORFs 59, 60, and 61 (Table 3; FIG. 2) lie between yopM and sycT. Orf59 is closest to yopM (242 bp away), on the opposite strand, and is predicted to encode a 4 kDa soluble acidic protein (Table 3), which is significantly smaller than typical Sycs. Orfs 60 and 61 lie 875 bp from Orf59, are separated by 272 bp, and are divergently oriented. Both are predicted to encode membrane-associated proteins with mildly basic pIs that hence do not resemble typical Sycs (acidic, soluble, ca. 16 kDa) or Yops (soluble). Orf 60 has an uncommon translation initiation codon (leucine) (Table 3).

ORFs 73 and 74 (Table 3) lie in the vicinity of yopE. The predicted proteins are 10-11 kDa soluble acidic proteins that show high similarity to unknown proteins of similar lengths in Mycobacterium tuberculosis ; however, neither ORF has a common translation initiation codon (leucine [ORF73] and valine [ORF74]). Both ORFs are predicted to be transcribed in the same direction, with Orf74 overlapping Orf73 by 8 bp (Table 1).

ORFs 84 and 85 (Table 3; FIG. 2) occupy the region between IS1617 and Tn1000p. They are separated by 139 bp and would be transcribed in the same direction. The predicted product of Orf84 is a basic soluble protein and the product of Orf85 is predicted to be an acidic soluble protein (Table 3).

We identified a number of intact, defective, and partial IS elements in pCD1. The site of an IS100 insertion, an element with numerous copies in the Y. pestis genome (Fetherston, et al. Mol. Microbiol . 13:697-708, 1994; Portnoy, et al. Infect. Immun . 43:108-114, 1984), was confirmed and refined. Two new IS elements, which we have named IS1616 and IS1617, were discovered (FIG. 2) and were registered through Dr. Esther Lederberg Plasmid Reference Center, Stanford, Calif. In addition, numerous IS element remnants were identified; these partial Iss primarily cluster in four regions of pCD1 (discussed below).

It is curious that IS100 is nearby one end of the yscM to yopD LCR cluster and two partial IS285 elements bound this same region (FIG. 2 ). The type III secretion system and regulatory genes, exemplified by this LCR cluster, is widespread among bacterial pathogens and has been suggested as a possible pathogenicity island (PAI) . PAI hallmarks include carriage of virulence genes, a distinct GC content compared to the host bacterium, a discrete genetic unit often flanked by direct repeats, association with tRNA genes and/or insertion sequences, presence of “mobility” genes (transposases, etc), instability, and absence in less pathogenic strains . An additional requirement of a chromosomal location may be somewhat artificial given the large sizes of many virulence plasmids. Although the LCR cluster does have IS elements associated with it, we failed to detect any tRNA genes anywhere on pCDT. In addition, the LCR cluster does not contain effector Yops (except for lcrV). Finally, the GC content of this region (44.8%) matches that of the entire plasmid and is similar to the 46-47% GC content of the genome of Y. pestis.

Insertion elements. Several mobile genetic elements have been found in the pathogenic yersiniae and most of them are present on LCR plasmids as well as the chromosome . ISs known to be associated with the LCR plasmid of Y. pestis include IS100 and IS285 Additional elements are found on the LCR plasmid of Y. enterocolitica but are not present on the Y. pestis plasmid Sequence analysis of pCD1 from Y. pestis KIM5 revealed the presence of three complete insertion elements and numerous partial IS elements. Complete and partial IS elements with >85% identity at the DNA sequence level were considered to be the same as previously described IS elements. For the remaining elements, the highest database match at the aa sequence level was considered the closest relative. Only complete IS elements were given new IS number designations.

An intact copy of IS100 is located downstream of yopH in pCD1 (FIG. 2 ). There are numerous copies of IS100 throughout the genome of Y. pestis KIM strains; the IS100 element (bp 12,609 to 14,562) in pCD1 (bp 12,609-14,562 of SEQ ID NO:1) is 100% identical in size and nucleotide sequence to a copy of IS100 present on the pesticin plasmid of Y. pestis strain EV76-6. A five base pair direct repeat flanks the IS100 which appears to have inserted within the relic of another insertion element. Five and seven base pair duplications have been found flanking other IS100 elements in Y. pestis.

IS1616 is a new 1,254 bp insertion element located at bp 50,753 to 51,987 of the entire assembled sequence, between ylpA and the sopABC partitioning region. The inverted repeats at the ends of IS1616 are 40 bp long and contain 9 mismatches. No direct repeats were detected flanking this element. While some elements do not generate a direct repeat upon transposition, the absence of direct repeats could be indicative of changes in the flanking DNA as a result of mutations that have occurred over time. There are three open reading frames within IS1616, the first ORF (OrfA, bp 50,825 to 51,142) is predicted to encode a protein of 105 aa with a pI of 12.6. A second ORF of 186 aa (OrfB, bp 51,064 to 51,624) overlaps OrfA in the −1 frame. An additional 101 aa (orfc, bp 51,625 to 51,930), which may have originally been part of the second ORF, are encoded in the same frame just past the stop codon at bp 51,622 for OrfB.

IS1617 is a new 1,214 bp element, with inverted repeats of 39 and 40 bp containing 13 mismatches, located downstream of sycH. The five bases flanking each end of IS1617 are identical in 4 out of 5 positions. Like IS1616, this element belongs to the IS3 family and contains 2 overlapping ORFs with OrfB in the −1 frame relative to OrfA. OrfA could encode an 88 aa protein (bp 62,202 to 62,468, complement) while OrfB is open for 289 aa.(bp 61,369 to 62,238, complement). A potential translational frameshift window of AAAAAAG is present in OrfA. IS1617 is more closely related to IS1222 from Enterobacter agglomerans and to ISD1 found in Desulfovibrio vulgaris than to IS1616. A remnant of IS1617 is present downstream of yopj in pCD1 as well as in Y. pseudotuberculosis pIB1.

We found no evidence for the existence of yopL and, in Y. pestis , ylpA and yadA-are pseudogenes. Although regulatory and secretory components of the LCR constitute a contiguous LCR cluster, elements suggesting this region is a pathogenicity island were not identified. Effector Yops are scattered throughout the plasmid and have widely varying GC contents, indicative of multiple gene acquisition events. This observation coupled with the presence of IS remnants from only distantly related microorganisms suggest a very complex history of DNA acquisition, insertions, deletions, and rearrangements was required for assembly of pCD1.

We failed to find genes with similarities-to putative virulence factors that are not potential members of the LCR. However, we did identify eight ORFs of unknown function (Orfs 5, 59-61, 73, 74, 84, and 85). Orfs 7, 42-44, and 75 as well as YopT and its chaperone SycT are potential new members of the LCR virulence system. Sequence analysis of Orf7 suggests that it could be a chaperone for YopJ. Further investigation of these Orfs will allow assignment of their functions as LCR members or non-LCR virulence determinants.

We corrected the sequence of yopM, showing that it has two additional LRR repeats that are absent in Y. enterocolitica . While most LCR-related Y. pestis gene products showed 98% identity to their analogous Y. enterocolitica gene products, YopJ, YscG, YscE were ˜94% identical to Y. enterocolitica products. It will be necessary to determine whether any of the differences in YopM, YopJ, YscG, YscE and the lack of a functional YlpA gene product are involved in differing levels of virulence among the pathogenic yersiniae.

An analysis was also done of the ORFs present in pPCP1. This analysis is presented in Table 4 below.

Thus the genes Y004, Y005 and Y007 are of particular interest as targets for use in treatment strategies due to their relationship with pathogenicity.

3

1

70559

Yersinia pestis

1

tttactctgc ttcgctgaat tttcgggttg atgtaaaacg tctgcaactg cgtgaattgc 60

atcaacagag ccggggagca gccggcagca gaacactgag tctgctgatg cgtcagtcgg 120

gttataacgt ggtgcgctgg ctggcccgca ggctgatgcg ggaatgtggt ctggcgagtc 180

gccaacccgg aaaacctcgt taccgtggcg aacgggaggt gtcactggca tcgccagact 240

tactgaaaag gcagtttaag ccgtcggagc ccaatcgtgt gtggagtgga tatatcagct 300

atatcaaagt caatggtggc tggtgctacc tggcactggt gattgacctt tactctttcc 360

attggtgagt tatccaggca gttacccctg cggctcatac tctgcatcac tccgttcctc 420

cacagtaact gcctgtattt cttactcctg tactgccctc cttgatccga atgaaacagc 480

agcctctttt cccttgggcg cgtctccagt gcattacgcc aggctcgaca caccagctca 540

gcatccgggg atgacgatat ggcactgccc actatccgac gggagtaaac cgaagcctga 600

aaagtgaatg gctgcctgta gggggctata tggatgtcca tcatgcggta cgagatatcg 660

gtgaatggat acaaagttat tacaacacac ccccatcggc acaatggtgg attaccgccc 720

tgtgaatacg aagagcggtg gaaaaaggct acgaaggtgt cctgattttg tgatccacta 780

caggatggat ctgttggtca atgccggcat tcctgtccga actgtcaaca gtttcaaagc 840

gcttcacgac aaggtgatta tcgttgatgg caagaatacg cagatggggt cgttcaattt 900

tagccaagca gccgtacagt ccaactcgga gaatgtgctg attatatggg gggacttcac 960

ggtggtacag gcgtatctgc agtattggca gtcacgctgg aataaaggaa ctgactggcg 1020

ttcgtcgtac tgatctcact cttttcgctg agtcattaat gtgatccgtg cgccaacacg 1080

ggttatgtct gcaaaagtta agtcgctgat ttcataaatc tgttgtattc tctgcgaaac 1140

gatccttgtt tgatctttga gggggctgat atgtcgcaga tcgaaaatgc agtaacttcc 1200

tcatcgaaac gtgcctacag aaaggggaac ccgttaactg gagccgagaa acaacgtatg 1260

tctgtttccc ggaaaaaaga gacacataaa gctataaatg tgttcattca gaacgatctc 1320

aaaaacgaac ttttacaact ctgtgaagat tcaggtttga ctcagacaga aatgattgag 1380

cgctggattc agagagaaaa ggccgctaga actaatgcag cttgaatggc aactaagtta 1440

ctttcttgat ccttcaggca gtgagtgcta gattaccgat tgtttaaaga atttttggct 1500

ggccacgccg taaggtggca gggaactggt tctgctaagg tgtttacttg gaaccagaaa 1560

agcaaaaacc ccgataaact tcctcatctt tggcgaggcg agaaggttac cggggcccac 1620

ttaaaactgt atagaagctg ttgctctata cagggagtat atgtgcatgt tcagaaaagt 1680

tcaatacctt ctgcgcttgt tactccttcc gtgcaacata agtgcgggaa ggtgtgacta 1740

accaccaggc cctgttcaca catcattatc gacaggttaa aaacccgaat ccggaattta 1800

cgccgcgaga gggtaaaaaa accctgccgt tctgccgtaa gctgatggcg aaagccgaag 1860

gcttcacatc tcgttttgat ttctccatgc acgtcgcatt cgcgcgttct ctgagtttgc 1920

gtcatcgtat gccgccgtta ctacgtcggc gtgctatcga tgcattactg cagggtatgt 1980

gtttccacta cgacccactg gccaaccgta tccagcgctc gattaccaat ctggccattg 2040

agtgtggtct ggcgacagag tcaaagagtg gcaacctttc catcacccgc gccacgcgtg 2100

cgctgcgctt tttatctgag ctggggctga ttacctacca gaccgaatat gatccacaga 2160

ttggctgtaa tattccgact gatatcacgt tcacaccggc gctgttttct gcgttggatg 2220

tgtcggacgt tgctgtcgca gcagcccgac gcagccgcgt tgaatgggaa aatcagcaaa 2280

gggagaaaca acgtctgcct agattggaga tggatgagct gatagcaaag gcatggcggt 2340

tcgtccgcga gcgtttccgt agctatcaaa ctgaacgtaa ggctcatgga ttgaaacgtg 2400

cccgtgcgcg ccgtgatgtt gaccgtacgc gccgtgacat tgaagctatc gttaaccggc 2460

agctgacgcg tgagatagct gaggggcggt ttgtcggtaa tctggatgcg gtacgcaggg 2520

agaaagcccg tcgcgtgaag gaacgcatgc tgatgtccag gaacaataac tacacccggt 2580

tggccaccgg cgctacctga cgtcgtattt actgaaaatc cggttagcgc cggaggattt 2640

cgctcgtctg cctcctgtca gtgcttgtta tttgagcgat gtgacggccg ctacatgacc 2700

tatcttctct ttcccgccct gaaaatgccc tcgaattctc ccaatatcgt cgcttgaatg 2760

tactgattta ggttatccac agttaactgc aagggaactt cccataaagt tacaaccgat 2820

atgtttttta agcgccagcc gaacttgttt taaagtgcgt ggtttctttt aaaccactga 2880

tcagcacttc ttttaaatac cttttctttt attcctataa ataaataacc tattcgtcgt 2940

ctgccttttg gacagactat gataatgccc gcccttgcag cgaacttacg ttcgcgccgg 3000

ttcggaaaca aagaaatacc tcctatcacg atgctacgag cgcataaacc cttattagtt 3060

acaacattca cgattcgacc aaaaaaatac cagaccgcat acatctgaga ccactgcgcg 3120

cacccttacc cactaaaaag ccgccccgcc ccgggccaac ggcccggaac agagtggctt 3180

tacaatgagt gttgtaacta aaattttcga gtcgctgcaa gtcatgtcgc tggaagtcat 3240

tcgaacacgc tcgtaagcgg ccctaatggc ccgctaacgc ggagatacgc cccgcctgcg 3300

gcaaagcctt gtcgggacca ctccgaccgc gtaatgaagc acctacgcta cttttagtgg 3360

gtttagcttt gcagggagga gattgggatt ggtgaaacct atcaaaccgg aaccggctac 3420

gccgggctat cggcgccaat tgtcaacaga gttatagtta atatccgctg gcgccttcat 3480

gccgcgatgc ggcattgaaa agaccggctg cgcactgctc gcctgtccgg taaggacatg 3540

atataaacgt ttgtgtttat aagcactttt gtggatatcg ttatgcagct gagtgactac 3600

attgacagtg tatacggaac agccgtaagc gagcggcgat ctcatattgt taactcactt 3660

ccgttatcac actctggtct cagtcaatac aacgaacctg aggtgaaata tgacgacacg 3720

gtattctcgt agtgaacggc agcaccatct cgacgcctgg caatagagct gaatgtctaa 3780

aaaacactac tgtcggctgc atgacttgaa catcgccacc ttttattact ggctcaaaca 3840

tcatcaagat gacaccaccg ttgccattcc ccctgcgttt atccccgctc gccgggtaat 3900

accagacaat aacggtaccg aggcagtgac cctcaacctc cccaatggct gttcggtcag 3960

ttgtcttcct gctcagttac gcgctgttat gcaggcctta tccctatgtt gacgccacaa 4020

cacatctggt tggcacgcga gccggtcgat atgcgtcgcg gtatcgcaat acattaccga 4080

ccatctgcat cagccctggc aaggcgaagc cgcctttgtc ttttgcaaca aaggcgcgtt 4140

cgcgtatcaa agttctgcgt tggaacaaac acggggtctg gttgtgaaga ggctgctgtt 4200

tcattcggat cagggagggc agtacaggag taagaaatcc aggcagttac tgtggaggac 4260

cggagtgatg cagagtatga gccgcagggg taactgcctg gataactcac caatggaaag 4320

agtgttccga agcctgaaaa gtgaatggct gcctgtaggg ggctatatgg atgtccatca 4380

tgcggtacga gatatcggtg aatggataca aagttattac aacacacccc catcggcaca 4440

atggtggatt accgccctgt gaatacgaag agcaggggaa aaaggctacg aaggtgtcct 4500

gattttgtga tccactacag caacggaata gctccgctca gttatctgac ggacagcttc 4560

ttccttaaat tcaggggtaa aacgtggtgt gcccatagac tcctcctatg cttaagatat 4620

aggtcagatt tgtctacagg ttcgggggct ccccaaatat ctacaataac taaaaatcag 4680

tggctggaag tgatatattc tgggacgggt ttaatcaatg atagatatca ccgtaaatca 4740

gattaaagag cttttgtgtg attaacacca cctttactga gttactccca aaaatagcaa 4800

gtcactttgg attagataaa ttgagccaag atgaatatgg cttgtgtgag cttatcctca 4860

acgaccgagt cgttattatg ctgagggctg atgaaatatt gaatcgattg actctgttgg 4920

ggccaatctt aggattttct ggaccagagg cgcgcagcgc cgctagtcag ctttttttct 4980

gttatagcat caatgccttg aataaggacg gcccttgttt cgcttggagt gaagaactgg 5040

ggctgatcgc attcaagcac ctttctctcg acgagctgaa tgttgagaac gttagcaagg 5100

agatagcgaa cttttacgac tggttgagct tggtcagttt accagcagaa actgcccctt 5160

catactcaat ctactcaatc ggttaaatgg ggatgagtaa agcatgaaaa gcgtgaaaat 5220

catgggaact atgccaccgt cgatctccct cgccaaagct catgagcgca tcagccaaca 5280

ttggcaaaat cctgtcggtg agctcaatat cggaggaaaa cggtatagaa ttatcgataa 5340

tcaagtgttg cgcttgaacc cccacagtgg tttttctctc tttcgagaag gggttggtaa 5400

gatcttttcg gggaagatgt ttaacttttc aattgctcgt aaccttactg acacactcca 5460

tgcggcccag aaaacgactt cgcaggagct aaggtctgat atccccaatg ctctcagtaa 5520

tctctttgga gccaagccac agaccgaact gccgctgggt tggaaagggg agcccttgtc 5580

aggagctccg gatcttgaag ggatgcgagt ggctgaaacc gataagtttg ccgagggcga 5640

aagccatatt agtataatag aaactaagga taagcagcgg ttggtagcta agattgaacg 5700

ctccattgcc gaggggcatt tgttcgcaga actggaggct tataaacaca tctataaaac 5760

cgcgggcaaa catcctaatc ttgccaatgt tcatggcatg gctgtggtgc catacggtaa 5820

ccgtaaggag gaagcattgc tgatggatga ggtggatggt tggcgttgtt ctgacacact 5880

aagaaccctc gccgatagct ggaagcaagg aaagatcaat agtgaagcct actggggaac 5940

gatcaagttt attgcccatc ggctattaga tgtaaccaat caccttgcca aggcaggggt 6000

agtacataac gatatcaaac ccggtaatgt ggtatttgac cgcgctagcg gagagcccgt 6060

tgttattgat ctaggattac actctcgttc aggggaacaa cctaaggggt ttacagaatc 6120

cttcaaagcg ccggagcttg gagtaggaaa cctaggcgca tcagaaaaga gcgatgtttt 6180

tctcgtagtg tcaacccttc tacattgtat cgaaggtttt gagaaaaatc cggagataaa 6240

gcctaatcaa ggactgagat tcattacctc agaaccagcg cacgtaatgg atgagaatgg 6300

ttatccaatc catcgacctg gtatagctgg agtcgagaca gcctatacac gcttcatcac 6360

agacatcctt ggcgtttccg ctgactcaag acctgattcc aacgaagcca gactccacga 6420

gttcttgagc gacggaacta tcgacgagga gtcggccaag cagatcctaa aagataccct 6480

aaccggagaa atgagcccat tatctactga tgtaaggcgg ataacaccca agaagcttcg 6540

ggagctatct gatttgctta ggacgcattt gagcagtgca gcaactaagc aattggatat 6600

ggggggggtt ttgtcggatc ttgataccat gttggtggca ctcgacaagg ccgaacgcga 6660

ggggggagta gacaaggatc agttgaagag ttttaacagt ttgattctga agacttacag 6720

agtgattgaa gactatgtca aaggcagaga aggggatacc aagaattcca gtacggaagt 6780

atccccctat catcgcagta actttatgct atcgatcgtc gaaccttcac tgcagaggat 6840

ccagaagcat ctggaccaga cacactcttt ttctgatatc ggttcactag tgcgcgcaca 6900

taagcacctg gaaacgcttt tagaggtctt agtcaccttg tcacagcaag ggcagcccgt 6960

gtcctctgaa acctacggct tcctgaatcg attaactgag gctaagatca ccttgtcgca 7020

gcaattgaat actctccagc agcagcagga gagtgcgaaa gcgcaattat ctattctgat 7080

taatcgttca ggttcttggg ccgatgttgc tcgtcagtcc ctgcagcgtt ttgacagtac 7140

ccagcctgta gtgaaattcg gcactgagca gtataccgca attcaccgtc agatgatggc 7200

ggcccatgca gctattacgc tacaggaggt atcggagttt actgatgata tgcgaaactt 7260

tacagtggac tctattccac tactgattca acttggacga agcagtttaa tggatgagca 7320

tttggttgaa cagagagaaa agttgcgaga gctgacgacc atcgccgagc gactgaaccg 7380

gttggagcgg gaatggatgt gacaagtgcc ccctaagcct tgagttgata tatccgagaa 7440

taggttaaga tttggcaatt gcttaacaat aattattttc ttattaaaaa tacctaacac 7500

aaaaaatacg ttatatatac aaatgaaaat ttccagtatt aatctcaaca agtttctcta 7560

ccggagaata ttaatctgga atgtgtaata gagaaaattt ttgatgctat caaattttcc 7620

ttttttgcag aaatatccaa tgtataggta tgataggagt tattgggaat ttttgttcga 7680

gtgctgcccg tctgttccgg gttcacccat caacgattga acgtcttatt gcaatgtacc 7740

gtttatctgg aatataaaat tcataccgct gttaattccc tgaataagga taaataaatg 7800

atcggaccaa tatcacaaat aaatatctcc ggtggcttat cagaaaaaga gaccagttct 7860

ttaatcagta atgaagagct taaaaatatc ataacacagt tggaaactga tatatcggat 7920

ggatcctggt tccataaaaa ttattcacgt atggatgtag aagtcatgcc cgcattggta 7980

atccaggcga acaataaata tccggaaatg aatcttaatc ttgttacatc tccattggac 8040

ctttcaatag aaataaaaaa cgtcatagaa aatggagtta gatcttcccg cttcataatt 8100

aacatggggg aaggtggaat acatttcagt gtaattgatt acaaacatat aaatgggaaa 8160

acatctctga tattgtttga accagcaaac tttaacagta tggggccagc gatgctggca 8220

ataaggacaa aaacggctat tgaacgttat caattacctg attgccattt ctccatggtg 8280

gaaatggata ttcagcgaag ctcatctgaa tgtggtattt ttagtttggc actggcaaaa 8340

aaactttaca tcgagagaga tagcctgttg aaaatacatg aagataatat aaaaggtata 8400

ttaagtgatg gtgaaaatcc tttaccccac gataagttgg acccgtatct cccggtaact 8460

ttttacaaac atactcaagg taaaaaacgt cttaatgaat atttaaatac taacccgcag 8520

ggagttggta ctgttgttaa caaaaaaaat gaaaccatcg ttaatagatt tgataacaat 8580

aaatccattg tagatggaaa ggaattatca gtttcggtac ataaaaagag aatagctgaa 8640

tataaaacac ttctcaaagt ataatgtatt ttggaaatct tgctccagta tgggaatacg 8700

gttcagttct ttctggctca tggtcaccaa catagacgct tcggattgcc tgcctgtgaa 8760

gaaacagatt aactggggtt ctacgccgga atcccagatt tttccgtcac cccagtttca 8820

gcgctgctag agtacgggtg gtatgagccg ctagcagaag ctctaaatag taacttcttc 8880

caatggccga aaaagaaagc gttaaaaaat cacagtacgg gcatttctcg ggtttacgtt 8940

atttgtgcag aacgcacaaa tcaggttatt agatattatt gcttatgaac gggtagtatt 9000

cagcgaaata cagctcctaa ataactgcgc caaatagtag atcactgagg gaactcaatc 9060

cggtttaagc gatctgatca atcgctgaat atcccaaatc accacaaccg gactgagtta 9120

tgccgatcat agcaccgata cccagaaata aacgacatca gatggaaaaa attgtccata 9180

aaacagcaga caaaaaccat tccagacatc tcatcgctga tccctcccca atatccgtac 9240

caggctaaat cagagatccg gacctttttg atgacttcgg gcaaattctg ccggagtcag 9300

gttatttaac gaagaatgcg gacgaaaatg attatattct tgccgccatt gttcaatttt 9360

ctcctgagca tcttccagag aaaggaaccc gtgcacgttc agacattcat ccctcagact 9420

gccattaaat gactcgataa aggcattatc tgtaggcttt ccggggcgtg aacagtccat 9480

cgtgaccctg ttttcatacg cccatcggtc catcgacttc gagatgaatt cgctgccgtt 9540

atctgtctgc agcctttgtg gaatacgccc cagcgaatgt tttaatctgt ccatgacagc 9600

cacaacatca tctccacgta acccctgacc gacctcgagc gccagacatt cacgactaaa 9660

attatccact atagttagcg ccctgacccg atgcccgttg aacagattat cagcaacgaa 9720

atccatgctc cagcactgat ctaacgcggt cacttctgga cgtgcgtgcc tgtgcctcgt 9780

tgtcacatgc cgccgtggac gtttcgaacg tagattgaga ccctcaagat aatcgcacgg 9840

aaaactgcat ccgtccggtg gccgtaggcc gcaagaactg gttgttcgca gggtcattgc 9900

gtgccgggca acggatggcg tccatcctga gtctgctgga aaccgccaaa ctcaacggcc 9960

acgaccctta tgtctggctg cgcgatgtac tgacccgctt gccgacctgg cccaacagcc 10020

agctcaacgc gctgctacct tacgccgaaa accgcttcag ctaattaccc cgccagctta 10080

ttgcattatt ttaatcgagc aacgcgagtt caccgttcgg ttacagtatt accatctgtt 10140

cccgcttaat tttttaaaaa atttaaggta acaatgagta tatatcttat gggaaaagcc 10200

aaaaaactaa cgaacactat aataattcga ttaacattaa tgaaaataca cggctcacct 10260

attattaaaa taatacgact agcattataa gaaaaaatat tttttatgtt tatagtatag 10320

gcgtgtattt aattaaggag ggaagcatga acttatcatt aagcgatctt catcgtcagg 10380

tatctcgatt ggtgcagcaa gagagcggtg attgtaccgg gaaattaaga ggtaacgttg 10440

ctgccaataa agaaactacc tttcaaggtt tgaccatagc cagtggagcc agagagtcag 10500

aaaaagtatt tgctcaaact gtactaagcc acgtagcaaa tgttgttcta actcaagaag 10560

ataccgctaa gctattgcaa agtacggtaa agcataattt gaataattat gacttaagaa 10620

gtgtcggcaa tggtaatagt gtacttgtca gtttacgtag tgaccaaatg acactacaag 10680

acgccaaagt gctgttggag gccgcattgc gacaagagtc gggagcgagg gggcatgtat 10740

catctcattc acattcagcc cttcacgcac cgggaacccc ggtgcgtgaa ggactgcgtt 10800

cacatctaga ccccagaact ccaccgttgc caccgcgtga acgaccacac acttctggcc 10860

atcacggggc tggcgaagcc agagccaccg caccaagcac tgtttctcct tatggcccag 10920

aagcgcgcgc agaactcagc agccgcctca ccacattgcg caatacgctg gcgccagcaa 10980

cgaatgatcc gcgttactta caagcctgcg gcggtgaaaa gctaaaccga tttagagata 11040

ttcaatgctg tcggcaaacc gcagtacgcg ccgatcttaa tgccaattac atccaggtcg 11100

gtaacactcg taccatagcg tgccagtatc cgctacaatc tcaacttgaa agccatttcc 11160

gtatgctggc agaaaaccga acgccagtgt tggctgtttt agcgtccagt tctgagatag 11220

ccaatcaaag attcggtatg ccagattatt tccgccagag tggtacctat ggcagtatca 11280

ctgtagagtc taaaatgact cagcaagttg gtctcggtga cgggattatg gcagatatgt 11340

atactttaac gattcgtgaa gcgggtcaaa aaacaatctc tgttcctgtg gttcatgttg 11400

gcaattggcc cgatcagacc gcagtcagct ctgaagttac caaggcactc gcttcactgg 11460

tagatcaaac agcagaaaca aaacgcaata tgtatgaaag caaaggaagt tcagcggtag 11520

gagatgactc caaattacgg ccggtaatac attgccgtgc gggtgttggc cgtactgcgc 11580

aactgattgg cgcaatgtgc atgaatgata gtcgtaatag tcagttaagc gtagaagata 11640

tggtcagcca aatgcgagta caaagaaatg gtattatggt acaaaaagat gagcaacttg 11700

atgttctgat taagttggct gaaggacaag ggcgaccatt attaaatagc taatgtaaat 11760

atttattcct atgagtaaat aaaattacta agagatatac accactttgc caatcaaaga 11820

aactttaaac ctcaactaaa gtaagcaatt agttgaggtt tatctgctgt agaataattt 11880

ttaacaaaaa tataaacaac aaaattaaaa gttatgtgtc tactttatgt aaccaaacga 11940

gcctgtccat aattctgtgt aatcgccact gtattaaagg tgatcgttta gacggtcacc 12000

gaactcgata ataaaacgac tcattgccaa ccgccagttt tgtattggca tgctccattt 12060

tttcgaagca tcccggatag ccagataaat aaccttccgc accgagtcgt ccgtcgggaa 12120

tactttgcat ttctttatcg cctgccggat cacactgttc agtgactcaa tggcattcgt 12180

ggtgtagatg gccttgcgga tatcgggcgg atagccgaag aaggtattga gattttccca 12240

gtgtgtatgt agtccctcct atttttagta ccaccgccag tgaggatctc catccagttt 12300

ttgtcttgca tagataacgg gtggcatatt acccagtgag ctatgcgggc gttcttcgtt 12360

atattccgtt cgccagtctt ctgtaagcgt acggacttcg gacagtgaac ggaacaaata 12420

catatcaagt atcactccgt gatgttctgc ccattcaacc agtgctgcag caataaattc 12480

tggaccgtta tcactccgta taaaagcagg atagcctctt tctgtactta atcgctccaa 12540

aatacggacc actcggtgta ccggtatatt caagtcaatt tcaattgcca gtgcttcccg 12600

gttaaaattg taacgaacgg tgcaatagtg atccacaccc aacgcctgaa atcagatcca 12660

gggggtaatc tgctctcctg attcaggaga gtttatggtc acttttgaga cagttatgga 12720

aattaaaatc ctgcacaagc agggaatgag tagccgggcg attgccagag aactggggat 12780

ctcccgcaat accgttaaac gttatttgca ggcaaaatct gagccgccaa aatatacgcc 12840

gcgacctgct gttgcttcac tcctggatga ataccgggat tatattcgtc aacgcatcgc 12900

cgatgctcat ccttacaaaa tcccggcaac ggtaatcgct cgcgagatca gagaccaggg 12960

atatcgtggc ggaatgacca ttctcagggc attcattcgt tctctctcgg ttcctcagga 13020

gcaggagcct gccgttcggt tcgaaactga acccggacga cagatgcagg ttgactgggg 13080

cactatgcgt aatggtcgct caccgcttca cgtgttcgtt gctgttctcg gatacagccg 13140

aatgctgtac atcgaattca ctgacaatat gcgttatgac acgctggaga cctgccatcg 13200

taatgcgttc cgcttctttg gtggtgtgcc gcgcgaagtg ttgtatgaca atatgaaaac 13260

tgtggttctg caacgtgacg catatcagac cggtcagcac cggttccatc cttcgctgtg 13320

gcagttcggc aaggagatgg gcttctctcc ccgactgtgt cgccccttca gggcacagac 13380

taaaggtaag gtggaacgga tggtgcagta cacccgtaac agtttttaca tcccactaat 13440

gactcgcctg cgcccgatgg ggatcactgt cgatgttgaa acagccaacc gccacggtct 13500

gcgctggctg cacgatgtcg ctaaccaacg aaagcatgaa acaatccagg cccgtccctg 13560

cgatcgctgg ctcgaagagc agcagtccat gctggcactg cctccggaga aaaaagagta 13620

tgacgtgcat cttgatgaaa atctggtgaa cttcgacaaa caccccctgc atcatccact 13680

ctccatctac gactcattct gcagaggagt ggcgtgatga tggaactgca acatcaacga 13740

ctgatggcgc tcgccgggca gttgcaactg gaaagcctta taagcgcagc gcctgcgctg 13800

tcacaacagg cagtagacca ggaatggagt tatatggact tcctggagca tctgcttcat 13860

gaagaaaaac tggcacgtca tcaacgtaaa caggcgatgt atacccgaat ggcagccttc 13920

ccggcggtga aaacgttcga agagtatgac ttcacattcg ccaccggagc accgcagaag 13980

caactccagt cgttacgctc actcagcttc atagaacgta atgaaaatat cgtattactg 14040

gggccatcag gtgtggggaa aacccatctg gcaatagcga tgggctatga agcagtccgt 14100

gcaggtatca aagttcgctt cacaacagca gcagatctgt tacttcagtt atctacggca 14160

caacgtcagg gccgttataa aacgacgctt cagcgtggag taatggcccc ccgcctgctc 14220

atcattgatg aaataggcta tctgccgttc agtcaggaag aagcaaagct gttcttccag 14280

gtcatcgcta aacgttacga aaagagcgca atgatcctga catccaatct gccgttcggg 14340

cagtgggatc aaacgttcgc cggtgatgca gcactgacct cagcgatgct ggaccgtatc 14400

ttacaccact cacatgtcgt tcaaatcaaa ggagaaagct atcgactcag acagaaacga 14460

aaggccgggg ttatagcaga agctaatcct gagtaaaacg gtggatcaat attgggccgt 14520

tggtggagat ataagtggat cacttttcat ccgtcgttga caaaaatctc cactacattg 14580

aataatctga acctccgacc gtctgtcagg gcatcactca taaaatcgac tgaccagcag 14640

tggttcattt taagtggaat agccaaaggt tgtggatgcc gattgggcag gcgcttttta 14700

ccttttcgcc gaaagttaag cttcagtaag cgataaacgc gatatacccg ttttacattc 14760

cacggtaatc cagactgccg taacttattg aacataagac caaagccata tgccggatat 14820

tgatgtgcca atttttgtaa tacctcaaca accggtatat ccctcgcggt gttaggacaa 14880

taatgcagca aacttcgact gatacccata atccggcacc cgcgccgttc actggcctga 14940

tattccgtca tcacgtaacg caccagttcg cgcttttcag gtaccgttaa agtttttttg 15000

ccacgacatc cttaagaatt tcatgatcta aactcagaga ggcatacatc tgctttaatc 15060

gtcggttttc ctcttcccgc tctttcattc gctttatatc agaggactcc atgccaccat 15120

atttggattt ccagttgtag taactggctt cagatccgcc gttctcgcga cagacatcct 15180

tcacatgccg gccaccttca acttctttta gaacccgcag gatctgagtt tcagtaaaac 15240

gtgctttctt cataatgacc tccgctgatt atatattaac cagagaactc cattaaacga 15300

taagactaaa ttcagggggg actacaagat aacggggagt ggacaatacg ttaataatgc 15360

gttattcatt tcaatacgca aatgtaattt aaactaatta tcatttagat aaatacgttt 15420

ttaattccaa tgccccgccg gcatggcgta aaaatataaa gtatccatcc ccccaaaccc 15480

tatttattag caataaggtc agctagccca ctggtaatgc aggaatacca gagatagcaa 15540

cgaatattga ctgggatgac atcaaaataa ccataacccg gcagtcgcta caatgtgatc 15600

tttcatccta attctctcaa tttatatgag gagcagactc tactgataaa tacccccact 15660

tcaggggatc accgaaggag gcgtattatt attctaaatt ggctcagggg aaagaattga 15720

tacatgactc cttgaaaaat ggttacgtaa atcaacctgg gggatattat tgcctcaata 15780

tacagtagat atatattatc tcagccgtca gccgccgtat cctggcgcat ggcggcttct 15840

agcaataatt tagcatcgct aagcgagagt tgttcagtac gcaagccggt cactatcact 15900

tcccctgcct tgccctgctt tagttccaaa ttagaaacgc gtggtaataa gcaggcaata 15960

tcgtgacgac tgagagccgt atttttcaca tgttccagca cctcattggc aaaggctttt 16020

tcggcggtag atatctgatg actattctct gtgagtgggt tagtttcagt gagacgaccg 16080

gcctgccccc cgtgtcccac ttgggtaatt tgttgattta ttaacgattg aagagtattg 16140

attttcatcg agtctcctgt cgctataatt gtctctacga tattctaagt tatttatttt 16200

tgctaaacta ctgtcgtaga cgatttattt ttttaatcgg cttttaaaca gaaaatcaca 16260

ataaaaaatt atttttggga atcattctca taaaacgagg atgaaaaatc caatttaggt 16320

agataactca atcttataat agataacact aaacatatat cgatagttat tcctattctg 16380

taactttcat ttgtcctaaa gtggtagata ttgcccgaga aagtgcttca atttgcccat 16440

caatactcgc gtcaataata cctacctcag tctctaatat acagccccct tgatccaaac 16500

gcgcatcggc agtcacctct aaatagctta tttccgggaa gtctttatgt actttagcta 16560

tttgttcacg aatagctcct gcctgatcag ggttgaccct gaccacgact tgcttctgat 16620

tactcaccaa ggctaaagcc tcccgcacaa cttgcagtgt catagccact tgatcatagt 16680

cattgaggat tttacgtacc gccaaaagta caacttcact catctgttgt tcgacgtggc 16740

gataaaattg ctgacattgt aactgtgttt catgaatcaa agtcgcctgt aaggtacgcg 16800

cctcatccat gccagcctgc catcctaact gcttttgttg ctcataaacc tcttgggcgt 16860

cagccaggat cttttcagca tcctgttttg cggcactaat caactcttcg gttgttaaac 16920

tggattggta atcttcggcg cgcaaaatac gcagaccgca agcgagcgag agattacttg 16980

gtattatttg aacaaatggc tgcatgtagg cgtaacctgt ttgacaagtt tgtgacataa 17040

agtttgggcc agtgggcgtt gtgactcggc cactaaccaa ggttctgacg gcgtagctaa 17100

tgggaggcgt aaactgagcc gtttacacca tgcctgaggt tggggttcca ttgctgctaa 17160

ccaaaaagcc agccccgact ggatcatggt acggctctct atttctgtcg gcagcgggcg 17220

ctgccagtga gtgggccaag gcccgattag cagctcatgc tgtacaataa tttgccttaa 17280

tgtttcttga ttaaccaatg tcaataattg ttgtaatggg gaggccagta cacaacggcg 17340

aatcgcctcc ccatgcagaa ctaatccaag gcgacaaagt aacagttcga gctgtgattg 17400

aggctgcaaa ggcagcgccc ccagcccatg gggctcttca tagtcggtat caagagaaaa 17460

ttcatccaat aaagcagcat tgagatgagc actatcgcgc cactgaggta agtagggcaa 17520

tattgaacgc cataatgatg gtaactgttc caagtgcaaa taagccgcgg ggcagaagcg 17580

caattgaaaa gaggtaatat aattttccat catcacttct tgcgttgtaa ccaaaaatat 17640

tgagcaagat tggtcactgg caaaagcaaa ataagcaacg acaacaagcc aataagatgc 17700

ccttttgact cttcactcac ttgaattgac agtatgctcg tgttacgagg taaatgagag 17760

ctttgacgaa catctaccga tggcaccaaa atgacactga tgcgatcata ggccagcccc 17820

tcaatactat tattcactaa ttgtttaatc tgaggtatgt aggtatcaaa ctgaatatct 17880

gctgcatgct tgataaaaac cgaagcggat gctgctacac ccttcttacc tttgttattt 17940

tgctcttcag gcaatacgac atgcactcga gccactaata ccccgtcaat ttcagataaa 18000

gtgcgggaga tctcttgcgc cttggcataa ttaagcctcg ccaactcttc tatcggtgaa 18060

gatatcaacc catctttggg gaacacatcc tgtaacgtgg agaaactctc gtgtggatag 18120

cccttccgtt tgagaatatc aatagcctga gcgacatctg actcctcaac caagagctta 18180

atcttcccat ctttgtctgg ctctttgtct gcggaaaggc cttcttggcg caacagcgca 18240

agcatttcgt tcccttcctt ctgactaatt ccggtataaa gatcaacttt gcaaccagtt 18300

aaaaacaaga ttaatatcaa tgttgacagt gaagtcttaa ctttcactag ttttcacccc 18360

cccttcgaca aggtttcaac attttggctc attcgcccgg cagtcttggc gataagttct 18420

tcttggattg ttatacggat aagtgaccat tgcattagca tcaggtcgtt gggattatca 18480

actgaaacag ccagcttagt gtgtaagtca cttttaaccg tcttaaaaga cttctgaata 18540

tcactaacct ccttgaggag tgaatggccc agtccctgcg tatcttctga cattgccgca 18600

tcaaagcgca ttatttggtc agttgttggc tctgccggcc ctaattcctc cagcgtggtt 18660

atgatcacct catcggcctg agctatttct atgttcggca tttatgtatc catatcaatt 18720

tgatggctgt tatgaagtag gctatctaca atcgagttag acggtaatag gatcattaat 18780

tctttattta ttaactctga taaataaggt aatccaacct ggctctcatt gggttttata 18840

ccctctaata cttggagcaa tattgcttcc caccgcttac caaacgagtc aaactgctgc 18900

aatacactac gcaattcagg taaatctata gccggtacaa cagacccttg atgttgaccg 18960

aaacgcgcca gtaacgcctc acgtactggc gtcgccaaaa cctcaagaac ggcatggtca 19020

ggagggttac tggcataata ttgctgccac agaacttccc gtgtcttttc agcggattca 19080

ctttttagct tattctccag ttgtgttttc agctcagatg ctaccggttg tagcgtagag 19140

actgcctgag acgaagacat caacgatgta atggaacctc tattaagggt aaccgtcatg 19200

tttttagttg ctccctcatt ccattcacaa atgtctgtat tctaggatcc tgactccttg 19260

cgagacgatt taaacgtgac tctaaggcgc tccccaaccc gaggcgatat tcacataagg 19320

ctaaccaagg ttccaaatca ggataagcta atttatttcc ttgttgcaag gcgcttgcgt 19380

agtccccacg gttcatcaaa gaggaaaggc gaatcaattg aaccgcctct tcttcacctt 19440

tcaaatgtaa ccattcagca atgcaattcg cttcttcgtg gtagtggttg ccggttccaa 19500

tcagagcaat ctctgctaac agtacgttga gtttatattt catattatgg gaacttctgt 19560

aggatgcctt gcattaagtc tttcatgcta cgaactatgg ttgagtttat attgtaaatt 19620

accgaccatt tattaattga atgttgtaag tcagcaagta gcgccgggtt gtcaggctta 19680

tctttcaatg ctgctatcga gtcattaacc gctttgtttg catcgtctgc tggcttcttg 19740

agcgtttgag ccaccgcatc taagtctgcg atatcggttc ctttcgtaaa tccagagaag 19800

ttactcattt attttaggtc tcctgctaca taatgaataa tggctatagc tgactcaaga 19860

gctttagatt ctctctgcca aacctgatac tgcttggcat caccaccgcg catcatatct 19920

tttttgagct tagttagtgc catttctagt tgcatggtga tagagcgcac tgtctccacg 19980

ttatgcagtt gctcctctaa ttgtgtcatc gaggtttacc tccattgagt tggatcacaa 20040

attcccgttt tcctttactc acaatcaccg catcgcgtcg aatagccaga atacgaacgc 20100

cattgttaag tatggcacct tctggatagc gttgatgatt gtcgagtacc acataaggca 20160

ctttccctaa cgagatagct tgcacctcga aattcaattc atcatgctgg ggttgccccc 20220

cgacattgac cagttctaat ttaggtcgat tgccaaactc ttggcgaaaa gtttgttgta 20280

gttgattaaa tgaattcaat ttttcatcat tgacttgccc gcgtaattca atcagctcac 20340

ctttaacatt tacagtgaaa tctgaatcca gaccaaattg ttcaagtaat gcatcaagcc 20400

gcttgcgttg attaccggca atccgcactt tactttctac accgagcagc cctggcactt 20460

cagcttgcag caggctatca attttttgct tttgtatttc ctctgacact tccccattca 20520

attgtagcca tcccgcttgc ggtgctaaag aaacctcaat tccatggtat cccaaccgtt 20580

gcaggatgaa ttctgccccc tgacgcagtt cttccatgct gcgcagttca agccggaatg 20640

gaatgccatg gctctcaaga aaattttgca gtgacaagcg ggcatgatta tcctggatat 20700

aaccagttaa taaccaaggt tcaccctctt ttttgggcga tgttaaaacg acatccttgt 20760

aagcagcagt tgccagcaag cgccgtactt cttgctcaac aagttgtcca tcctggttat 20820

actcgcgcca caatccgtgc cctagcagcc ccaaaaaagt caaaagcaac aataaagaaa 20880

gaactccaag cccaatccca agtcgtgaac gaggtaacct gtcggttggc tcttttctct 20940

gcgtgggaac ctgtaacgtc tctggcaaag gttgccctac ggcgacaaat gtccacagta 21000

aaaaacctac ttccagacaa gagcccgcgc gaagaagagt ccccaacggc acgggaagcc 21060

cttcttgtag tagaggttct gcagaatcag ttaggcgaat accttcttca tcgaccatca 21120

gcactaaatg cacgggtgct atttcgctgt cagaaagaac aatatctgac tgcaacgggt 21180

ctgaaccaaa aacacagcgc ccatgaggaa gctcaacttc aacaccacgg tgcttccctt 21240

gataaaaacg acagacccaa ctcacaatac gccacgctta ggcgctgaaa cacaccatga 21300

ttccgcggga gtacaagcac cttcaaccac gcgccatccc aaacttttgt ccatcttgca 21360

ctgagtaaga taggatgatt tattgttttg actcagccat ttctgcactt cttgcgcttt 21420

gtttaaaggc tgacactgga agccacctaa taacttattc aaggtagtgc tttgattaga 21480

tatttcatca acagctaaga taccagtacg tagatcccga ccattaccta acgctaaatg 21540

atgcgcaata ccttcgtcaa taatccgtgg ttcgatgata aacagccgta ccgtacggcg 21600

agttaactca cttttacggc ggaaaagtgc gccaagataa ggaatatcac caagcaaagg 21660

caccttacta agagcaacac tcaattcgtc acgataaata ccaccaataa tcaaactctg 21720

gccatgtccc acgcgagcga cagtatcaac gaccgtacga ctgatagtgg ggattccgtc 21780

aatccctgaa ctattcggtt tttggttccc atcctcaatg tgtagattga gactgatttc 21840

tgacttatct ccttgagtca gcacccttgg tgtcatacgc agcatagtgc cgtaggtgat 21900

ccctttcagt tcagccactt ctttacctgt cactttgacg taataggttt catggtgatc 21960

aatcaccgct tgggcatttt cttgtgttag cagggtcgga cgtgaaacaa cttgagccga 22020

accttcattt tcaagtaaat tgactcttgc taataggtag tcaagcccgc gagcatcaat 22080

caaactaccc aatgcaccgt ttgaagcgat gttactttga tccccggttg tttttattac 22140

cacctgatga ttgttgccag tacgaatgcc aactcgccag tccacaccta attcagtaag 22200

ttggtcggca tttatatcga caatggataa cgccacttca atacgagcgc taggtttatc 22260

aagcgcatga attaaccgtt gatacattgg catacgctca ggagaatcgc gcactattat 22320

cgcattgagc gatggatccg cttcaacctt ggcttgagct gaagcccggg tagcggcctg 22380

cggtattctc tgattatcca ctgtcacttg ttggattgtg gcatcgctta acacgcgttg 22440

aagtatcgtt gcaaccccag gagcagccac ttcgtcatca cggtaatgaa tagttcgatc 22500

gctcgctgat gcatatttga gagggaaaat ctcaatcgct aatgcccctg ttttttcact 22560

gcgaatttgc gtctgttgtt ccaatgcggc tgcggtctgt tcaaccaatt caagataacg 22620

aggaggacca gagacgtaaa caaggcggtt gctagcatca gggcgccagc caaaacgagg 22680

ctcccatata ccagaacgtt gtaatgccag ctttaactct gcggcctcac tttcctgtaa 22740

acgaatgaga cgagacgcta cctcactatt tttaaaaatg tagagcacat tgccatcata 22800

gtaccaaacc aaattgtaaa gggaggcaat atgctgtagg aaatcctgag ggttatcatg 22860

ctcaaactgg ccggaaactt tgtcattaat cttatcgctt actaccactg tagcatcata 22920

attagcgctg aaatcaatta ataaatcgcg taaactttcc cccttcgcca cataaacata 22980

aggtataggc aaccaatcaa gttcttgcgc ccagctatag ttagaaagta acagtaacgt 23040

cccggtgagt acgcgcttga aaaaagaatg tagcggaaaa gccatattac ttaattccac 23100

cccacgcgag acgctacaga aaatggtgtt aactgaggaa ttaaatgttc tagcagagcc 23160

agttgtttat ttattacttc ttgcaatccg tgagtatcaa gctcttgtag acgtaaacgc 23220

gcctccagta ccaattgacc acaatcatcc aatactaaag tttgagggta acgtttagcc 23280

catgccaacg cttgttgcat tagggagcga agcaatgtga cgttaacgtt atttccttca 23340

cgtaacattg gtgcgtcaat aggagtgcgt aataccagtt ctgaaccatg cggagccagc 23400

atgacaagat gcttatctat agttaaacgg taaacacctt gtttatcggc aacaaacggt 23460

tttcttccta aactggctgc caagtttttt agtaaatttt gcattatttc tcggatggtt 23520

atatataaac taagtaatcc tgcgccaaat aaataaccta cttcatgtca tcgtgacata 23580

aggtttcgcg gttcagctca aacttccaga tattcaaaaa aatgttcatg ataattatca 23640

accacctgta tagcaataga tgatattacg ttaatcgaac taatgagact tgctctattt 23700

gatggaggtc gtttcttgcg ccaccgcact taataaacca gataagctat attgattatt 23760

aaacaacata ttattgccat ccagcggcga aacaatactg ttctatgttt cgttgaaatt 23820

tggctcatcc cattgaatct tcacaatcta atcccgtatt ttactttata gtccaaaagt 23880

gtcttttaaa aaaaacacag ataattttag cctgtggttg ctattttagt aagacgggct 23940

tggcttggag tgcatccgaa gcgacgtcga taactttgag tgaaataaga ctgactcgag 24000

aaccccgctt ccatggcaat atcaacaata ctcatcttac cattaagaag taattggtga 24060

gcatagagaa tacgtcgctc gcttatccag gcgcgtggtg aaatgccata aactgtacca 24120

aacagttctt tgaatgtggt taatcccatg ccgaattctc gcgcaaattt gcttagcttc 24180

cacccttgta gataattttc ctccataaat ttttgcaacc gttcttctgg gcggttgcct 24240

aaatggcgca gagccgagag aaataaagtc ccttgcgagc taaaggcaag caaaagcagt 24300

aattcctcaa tacgcagttg cgttaatact gacggaaaat cactccgttc caatatggca 24360

catagatttt gaatggattg tgataatatt ggtgaaatat taaaaattaa caatggtttg 24420

ggtgtggagt tgtctcgtcc aatttcacta agcaaagaac caaagcgatg caaaaaagta 24480

ctcaaaaaac tgccgggtaa tggaatccaa agtaattggc agggttcttt tgtaccacat 24540

cgaacagcat agctgccacg acgcaaaaac agcatattcc cctcatctaa atcatatgtc 24600

tgaccgctgc tctgccatga aatctgacct tgcaaaagaa tatataggcc atcttgtgaa 24660

tgctcaacaa ccttaaatat aggtgtgacc cattctaatt taataatctc tagtgatgcc 24720

ataaatgtta tactgtccta aaaatctaaa acttgtatat atttatctaa tgaggtgtat 24780

tgagttatta tgcgtgcgat gtacaaccat cgattaatgc aaccaaaacc aatataataa 24840

atcacctatc tggtattagg taactggcaa tttggataac atgttttagg tatcatttgt 24900

aaaacgactt tgtttttacc agtaagcttt tgctgagcca ccgcctgaac tcctcgctct 24960

ggaaaagaga gggttgaccg taggtaaagt tcaccttccc cgcgttgagc tggattcagt 25020

tttatagaaa agaataaagg taggttacct gtttcgaaat gagtgcgctg aacctctcga 25080

actttcccct catacaaccc aaacatacta acatcaatgt gtgctatgcg agataatggt 25140

cgtgacatac gcacctcccc cacaatacgc tgagctggca ttgggggggt agcgcacccc 25200

actaatagaa aagaaatgat gagtgctata atacgactca cgccagtccc tcccttgagt 25260

tcacacaaag aagatagcta gatgatagca atccgagttc gcgcaatatg tggtgaaatt 25320

tattattgta aaataacaac ccattcccaa ttatctcaac gggtccacca cgaactcatt 25380

taatttagct actgcaatat cacaccttgc gcatataaag ccaaacatcc tttctttcat 25440

aaaaaaagga tgtttggtta gaatcggaat cagcaaacaa acacatgtaa tagtaatgac 25500

aatactgtat tatttgtatt caacaaaaaa aagtcaagag attaatccta attagtgcta 25560

gttatgttta attgtaaaat gcacaggaga aatacaatta ccatactgta tatatggttt 25620

taaatcgcat catatattcc taatataagt gaacctcttg ttggttaacc atatcgaata 25680

aattacatat tcccaatagc cggtgttaat caccccattt ttccgataaa aacatagact 25740

agaaagtaga gaaaatagta tagaccaaca aaaatgtcat ctgttttaac catattccta 25800

gttacattgc agcctattat aacatttcgg aatgttgttt ctcgatattt tgcctttcta 25860

gccatcgtag cacttcagct gtggcctcta tttgctcagc cggaatatag tgatcgacga 25920

gcgcatccca ataaagagca cgggctaatg ggatacgttg taaaataggc accccttctt 25980

cttctgctat tttgcgcaca gtctgaactt gggcatcggt atatttgaat gttaccaacg 26040

gtagtggtgt ttcccctcgc ttgtaaagaa taccaatagc aatatgggtc ggattagcta 26100

ccaccactga tgagcgttta acattttccc gcatgttcct cgattggatc tcttgatgaa 26160

actgacgacg cttgcttttg atttctgggc taccctccat ttctttgtac tcgcgtttga 26220

tctcatcctt gctcatttta agttccttaa tatattgata gtattcaaag gcatagtcgg 26280

ctatggagat gaccacaaag ccaacagtac agataaccat caactgccgg agtatttgcc 26340

ccaataaagg ggtaatacat tcaattccac aggttggcaa ctgcaagagt gtgactagat 26400

ttcccttaat gattatccag atgagtatac tgagcaaaac aaccttgaga atggatttga 26460

gaaactccac taaacttttg atggaaaaga tacgcttggc accctctatt ggattgattt 26520

ttttaatatc cggtttaatt gcttcaccac ttataagaaa accatactgc acaacatgag 26580

atgcgatcgc cattaatgcc gccactgtta acaaaggaaa acagagataa aaaaactcga 26640

gcaacacatt gtcaaccaca tagctaagcg cctgcgagaa aggaagatag ctctgctctg 26700

cggggattag catcagctta ctaaaatgct cgaaatagta gtcagaaagc cccattaaca 26760

tcgcactcag cgcgacgata agcgcagtag agaccacttc cttacttttc gctacctgtc 26820

cctttttgcg cgcatcacgg attttcttcg gggtgggttg ctctgtcttt tctccgctca 26880

ttacttctcc aaaacaggga tcagtaaact tataggatcc ataaccaaca gcattgcttt 26940

actggcatga ctcatcattt gcatacagta gataaccaac aacaggcttg ctatcgcgct 27000

ttttatcggc atagccagca caaagacgtt taaagaaggc gcaaaacgac tgatgagtgc 27060

aagtccaaat tcagctaaaa acatagcgat gagtaaagga gcagccaata cagcggcgat 27120

taatagtatc tggctgaatt ggttataaaa gaaatcaacc cactgttcac taactgcagg 27180

gaaaaagctg gccaccggcc aatttacata gctgtgaaag agggctgaaa gcaaagagag 27240

gaaagcccct ccgctgaaga aaattgttat taacgtttga gtcaaaagta aaccagtcgg 27300

actagtttga ctatcaagtc caggattgag tagagatgcc atcgcggcac ctctttggtt 27360

atctacaata aatcctgcgg attctaaggc ccagaaagga atggtggcca caaacccaat 27420

caataacccc agtatgatct ctttgccgat aagcagcatc aacgtaaacg catcaacctc 27480

aatataaggt tggttagcga cggcaggata gacataaaga gccaatgaac agacaatacc 27540

attacgcagc aatactccac cgaggagctg tttacttaac actggcaata taacaaaaca 27600

agccataaaa cgaggcaaca gcagggtata agtgagcaat ggtctttgga ttaaatccgc 27660

tatcatctta tgccttgtat cttcatcatg gtcatttctg caaaactgtg caattcatta 27720

ccaagccacg aggcggtagc aaacagtgtg accaccacag cgatcaattt gataacgaag 27780

cccagagttt gctcttggat ttgcgttaaa gcttgtacta aagataccaa agttcctacc 27840

accgcagcca ctaacaccgg cggcattgaa aggactagca ccagccataa tgcctgactg 27900

gtgaagtgaa ttatgtcacc ttgactcatg tcaccctccg tagctaatca ccagcccatg 27960

cgtgagtcgt gtccagccat caagtaaaac aaatagcagc aatttaaatg gcagtgaaat 28020

agtcatgggg gaaaccatca tcatccccat tgccaacaag atattggaaa taaccaggtc 28080

aatgacgata aatggtaaat agatgagaaa gcctatctca aatgctcgag tcaactcact 28140

caccgtaaac gcaggcaata aaatgaacag gctgtctgac tctaaccggt cagcatactg 28200

cttgggccat aactgtttag tgctgtcaac aaaaaaagag tattcttgcg cttgaatatg 28260

ctgcttaagg aacatgcgat agggggcaag cccttcatca aagaatttct caacagattc 28320

tatgttcgtg aggctaacct cattagcttg taaatagtct tgcgtcgcga agccaacggg 28380

tgccattaca taaagactaa ggatgattgc taagccatac attgccatgt tgggggggat 28440

ttgctgtacc ccaagggcat tgcggagtag tgaaaagacc accgcaaatt tgacaaacga 28500

tgtagccatt accgaaatca atggaagcag agtcagcaaa gataaaacga tgatgagatt 28560

aatttcatcc ggtaactgga tcatgaaatc gtaacctctg tcaggcgttc aattcgaacc 28620

ccgaggcgcc cttggatctc gaccaatcga ccatgtccaa gcaaccggcc gttagccagc 28680

aagcgcactt caccatcaac aggtgttgta agatcaataa gagaacccgg ctccaggcta 28740

gtgagtgtgt gccaatctaa gatttgccgc cccacttcaa agctaacttg aaccggaagt 28800

tggttcaaat cggtcaatgg ttcggggtta agttcgtcag attcatgact cataccgata 28860

aactccaatt tatttgattg taattgaaag tagccccaag ggttctcacc aacataggcg 28920

agtactggcg aattaggccc actcccctca ggggccaaca acacatcacc taatcgaagg 28980

gaatcaacct catctagagt caggtatact ttatgccaac gcaaagaaat aaggataggc 29040

aaaggtatgc gctcagaatt gggtcgtgcg ggtaacagag cgaacagagc ctcagctgag 29100

gttagccaga aggagatatg cgcattatct cgggacagcc gcaaactcaa cagaggttgc 29160

gtgacagaaa gagacgctgt cgctatatca ttacagacca gtttcggcag gaaaactgtc 29220

tggcgttcca acagcgcaag ttgcaactct ttcggcagag taaagaatgg agcccctagt 29280

aagtcggcgg ttaaccagtt agccagatca ttgccaaaac agtagagcgt gaagtgcgtt 29340

cccttccatt gtaactgtaa tatacagttc aaagacgaag gaggctcaga gacggtaagt 29400

tcgagttttc cctcttccca caagtagttt tgttgataat ggctgagccg ttgacgtagc 29460

gacagttcac ttaatttggc ctgtggcaag gttaacaaac tcattcttca gcctcccact 29520

cctcatagac gtggcgtttc tgacgtgact cctgttcact gtcatcgcta gcttgaaaat 29580

caagttgtgt tggctcaatg cgttgtaatc gctcaagaag atcataactt ccctgcgcta 29640

aaattcttaa agcttcccga ctggcgatca gttctacatg cagttttccc ggaatctcag 29700

caatacgaac cataatagcc cccaattcag gtaagttaag gtgtaattgg gttacttggg 29760

atgagccgcc gcgcagttct agttctaccg ctagtcgctg tgctaactgt ataagttgct 29820

ctgagactga tgccagcctg gtcgcgcgca ttgttgctaa taggtgatca cccggcgtga 29880

caaccggtgc tgtaaaagac aaggaataca tctccggcaa ggtttcttcg cgcggaagta 29940

acagtttttc tggtcgcggt ggttcgatgg tatctttgct gctatcaacg ccatcagtaa 30000

gatgttggga ccgatccgcc agctcggtca tgtccagttg ctctgactgc actgtcgctt 30060

tgtacggaaa acgagcagat ttttctgcta cctcagtcac aggagtagca caccatcttg 30120

ctaccaaatg atcatccggt gtggcactaa ctgccggggg acatatctct ggcaatgctt 30180

tttgatgaag agctaacggt tcttctgcaa ggcgtttttg cctgctatcg cgctggtttt 30240

ttgctatact ggccggagtt tccctaccga cagaccatac aataacctct gcgccgtcag 30300

cagccggatt caatggctga acagtcggct tgctattcaa ttgaactggt tgagcggaat 30360

cgataggcga ttgctgaaca aataactcat catgtccaga cggctcgcag ggggattcac 30420

ttgatgtccc cgtttcacaa gtcaccccct ctaaaaaggg cgccaatggc atgagagcat 30480

taataatact ctctacgcgg tcatcaaaac ggctatcctg ctggtataag tgcgctctat 30540

tggtagcacc ttcggcaagc ggagataagt tgaaatcatg attattctga tggttgtgtt 30600

gaggttttaa tcctacctct ttccttccgg gttgagacgt cgccgctaat ggcgcatgcg 30660

cacgcaagcc atctcctttc tgaccttctt ttttgccaag gtcatgcgga cgtacaggtt 30720

taagcgactc ttctttggga tgacaattcc ccttattatt atgcaacagc gcttgctcaa 30780

aatcgacaca tgcttgcaaa gcatgatgcg gcttccccag aggttgatac tcaggttcta 30840

atggggaacg agtggtgatt ttattcatta ggcgttcctg tgatgctgta gaaactcttc 30900

ttgttcttgt tcttcctgat aatgttgttg atttagctca tcttcatctt ctcgtcgcac 30960

tagctcgaga aacttatttt ccttatgacg agcctgttgc agcatctttt ggcataacgt 31020

aaggcgctca cgctcattgg ctaaacgttc caataatttg gcgcactcca gttcataatt 31080

ggcctccttt tcacgtagcg acgctatttg tcgctgccat ttctccaaat ctttacaatt 31140

cagtgtggtg ttttttcgct gatcaaatag acgttgctcc tcatcaatac gccacaaatg 31200

gtaatcctga ctggtttgca ccgcctcttg atgacgtcga tgagctgcct gcaagcaagc 31260

ttgctgagtc ttgatggctt tctccgcacg ttcaacgcgt aaaactttaa cccggtgcag 31320

gcggcgtatc attgggtcag cgtctccaat aagttcagcg tctcattgaa atggcttaac 31380

tcgtgcgtcc cctggcagag ccatcctcga atcgccccca tgcgttcaat cgcttgatcg 31440

gcctctttgt cttgcccttt ctggtactcc ccgatttgca acagcaattc cacttcttca 31500

tatttggcca ataaacggcg taagtccccc gcccaggttt tgtgctcctt gctgacaatt 31560

tgattcatca ccctgctcgc tgaacgtaat acgtcaatgg caggataatg attagctgcc 31620

gctaatttcc gtgacagaat aatatgacca tcaagtatcg aacgtgtttc gtcggccacg 31680

ggttcggtca tatcgtcccc ttcgaccagt acggtataga gagccgtaat tgaccctttg 31740

ctggactgac cagccctttc catcaaacgg ggtaaagcgg caaatactga cggaggataa 31800

ccgcggcgag tcggtggttc tcccgcagct aagcctattt cacgctgagc acgagcaaac 31860

cgtgttacag agtccataag taacaatacg cgtttccctt gatcgcgaaa atattcagca 31920

atagatgtcg ccacgaatcc agctttggct ctttccattg agggccgatc cgaggtggcc 31980

accacgagaa ccgctttgcg taacccctct tcgcctaaat cagactcaat aaactcacgc 32040

acttcgcgtc cacgctcacc aataagcgcc agcacggtta cgtctacttc agcactacga 32100

ataagcgaag caagcagtgt acttttcccc cccccggcgg ccgcgaagat gcccattctt 32160

tgcccctcgc cacaggtaag caaaccgtca ataacccgga tccccaaaga aagtggtgtg 32220

gtaataagtt ttcggctcat cggcgctggg gcatcctgat aaactgggta ccaagccgcc 32280

ggttcaggga gatgcccccc atcgaaaggc tgccctaaac catccaacac ctgtcccagc 32340

agatgttcac ccaccccaac ctgatgcatt gtccctgtcg ggctaacttc agtattagaa 32400

gatatcccgt acatttcacc aagtggaata agtaatgctt gatgttgggc aaaacctatg 32460

acttcagcct gtaaagacag gctgttgtca gggttacgta agtaacataa ctcaccgatg 32520

cgcacacctg gcactaccgc ttttaataac gttcctgtca cttgagtgac acgtcctcta 32580

atttggatta ggcggctacc tacaatgcca tgacgaatat gatgaggtat ctgatctagt 32640

gagagcataa atccataatg gttgaaatat taaccactat tttagtgact aaaaacgcta 32700

aaaaattgta gcgggagccg cgagttttta gaaaaatagc caagcagcac taaaatttct 32760

cggctgattt tggcatcgat aagcaagaac tatttttata atcgcggtaa ttgtaattat 32820

aaactgttca tctcagggag tagttatgac gacgcttcat aacctatctt atggcaatac 32880

cccgctgcat aatgagcgtc cagagattgc cagtagtcag atcgtaaatc agactctggg 32940

tcaatttcgg ggagaatctg tgcagatagt cagcggcact ctgcagtcta tagctgatat 33000

ggcagaagag gtaacatttg tcttctccga gcgtaaggag ctctccctcg acaaacgcaa 33060

attaagtgac agccaggctc gagttagcga cgttgaggag caggttaatc aataccttag 33120

caaagttcca gagttggaac aaaaacagaa tgtgagtgag ctgctcagtc tgttgagtaa 33180

cagccccaat ataagcttgt cccagttaaa ggcttatctg gaggggaaat cagaagaacc 33240

gagtgagcaa ttcaaaatgc tctgcggctt gcgtgatgcc ctgaaagggc gccctgaatt 33300

agcacatctt tcgcatttgg ttgaacaagc tctggtcagc atggctgaag agcaaggaga 33360

aaccattgta ttgggtgcca ggataacccc ggaagcgtac agagaatccc agtcgggtgt 33420

taatccactg cagccgctcc gtgataccta ccgcgatgca gtgatgggtt atcaaggaat 33480

ttatgcgatc tggagtgatt tacaaaaacg ttttcctaat ggggatatag actcggtgat 33540

attattcctg caaaaggcgc ttagtgcaga tctacaaagt caacaaagcg ggtctggacg 33600

ggaaaaatta ggaatagtta ttagtgactt acagaagcta aaggagtttg gtagcgtgag 33660

tgaccaagtt aaaggatttt ggcaattttt ttcagagggt aaaactaatg gcgtacgacc 33720

tttctgagtt tatgggagat attgtcgcac tggttgacaa gcgctgggcg gggattcatg 33780

acattgaaca tcttgccaac gccttttccc ttcctacgcc tgaaatcaaa gtgcgtttct 33840

atcaagattt aaaaagaatg tttcgtcttt tccctctggg ggtatttagc gatgaggagc 33900

aacggcaaaa tttattgcaa atgtgtcaaa atgcgatcga tatggctatt gagagtgaag 33960

aggaagaatt gagtgagttg gattgaaccc atcatttccc atttctgcca ggatctggga 34020

gtgccaacat ctagccccct ttcgcctctt attcaattag agatggctca atctggcacg 34080

ctgcaactgg aacaacatgg tgcgacactg acattgtggt tagcgcgttc tcttgcctgg 34140

caccggtgcg aagatgctat ggtcaaagcg ctaacgctca cggcggccca aaagagtggc 34200

gctttaccgc tgcgagcggg gtggttaggg gaaagtcagc tggtgttatt tgtctcgctt 34260

gatgagcgtt ccttaacctt gcccctttta catcaagctt tcgaacagtt actgcgattg 34320

cagcaagagg tgcttgcgcc gtgagtcgca taataactgc cccccatatt ggcatcgaaa 34380

aactgtcggc gattagcctg gaagagctat cctgtggctt gcctgaacgt tatgccttgc 34440

cgcctgatgg gcatccagtc gaaccacatt tagagcgcct ttaccctaca gcacaaagca 34500

agcgtagcct atgggacttt gcttctcccg gctatacatt tcatggatta catcgagctc 34560

aagattatcg gcgcgaactg gataccttgc agtcactgct aaccaccagt cagtcctcag 34620

agctacaagc tgccgcggcg ctgcttaaat gccaacaaga tgatgatcgg ttactgcaaa 34680

taatccttaa cctgttgcac aaagtatgaa tattacttta accaaacgac aacaggagtt 34740

cttgctgctc aacggttggt tacaactaca atgtggccat gcagagcgcg catgtattct 34800

attggacgcc ttgctgacgt taaatcctga gcatttagcc ggtcggcgtt gccgattagt 34860

cgcgctactt aataataacc agggagaacg tgccgaaaaa gaagcgcaat ggctaatatc 34920

acatgaccct ttacaggctg ggaattggct ctgtttgagc cgcgcccaac aactgaacgg 34980

cgatcttgat aaggctcgcc atgcttatca acattatttg gagttgaaag atcataatga 35040

atccccatga tcttgagtgg ctaaatcgta ttggcgagcg taaagatatc atgctggcag 35100

tgctgctgtt agctgtggta ttcatgatgg tcttaccact cccccccctt gtgttggaca 35160

ttctgattgc tgttaacatg accatttcag tggtgttgtt aatgatagcg atctatatca 35220

actctccttt acaattttca gctttccctg cggtgctact cgttaccacg ttatttcgtc 35280

tcgcactttc agttagcacc acccgcatga tcctgctaca agctgatgcg gggcagattg 35340

tttacacctt tggtaatttc gtcgttggcg gtaacctcat cgtcgggatt gtcatcttcc 35400

tgatcatcac tattgtgcaa tttttagtga taacgaaagg ctcagaacgt gtagcagaag 35460

ttagtgccag attctctctt gatgcgatgc cgggtaaaca gatgagtatc gatggcgata 35520

tgcgagccgg ggtgatcgat gtcaatgaag cgcgtgagcg acgcgcgacg atagaaaaag 35580

aaagccaaat gttcggttct atggacggcg ccatgaagtt cgtcaaaggg gatgcaatag 35640

ccggcctcat tattatcttt gtcaatatat taggcggcgt caccattggt gttacccaaa 35700

aaggattagc ggccgctgag gcactgcaac tctattccat cctcactgtc ggggatggga 35760

tggtttctca ggtacctgcc ctgctgatag ctattaccgc gggtattatc gtcacccgcg 35820

tctcttcaga agattcatca gatctgggta gcgatattgg caaacaggtt gtcgctcagc 35880

ctaaagccat gctaattggt ggcgtactgc tgttgctctt tggtcttatc cccggcttcc 35940

caacagtcac ctttctgatt ttggcgctat tggtaggctg tggtggttat atgctcagcc 36000

gtaagcagag tcgtaatgac gaggctaatc aagacctgca atccatactg acgagcggtt 36060

ctggcgcccc ggctgctcga accaaagcca aaacaagtgg ggcaaacaag ggccgactag 36120

gggaacaaga agcatttgct atgacggttc ccttgctgat tgatgtagat tcaagccaac 36180

aggaagcact ggaagcgata gcactaaatg atgagctggt tcgagtgcgc cgtgctcttt 36240

atcttgatct tggcgtacct ttccctggga tccatctgcg ttttaatgag gggatgggtg 36300

aaggcgaata tattatttcc ttgcaagaag ttccagtggc gcgaggtgag cttaaggcag 36360

gttatttact cgtgcgtgaa tccgtcagcc aactcgaatt actgggtata ccctatgaaa 36420

aaggggaaca tttgctaccc gatcaggaag ctttctgggt atcggttgaa tatgaggagc 36480

gcctggaaaa gtctcaactg gaatttttct ctcattccca agttctaacc tggcatcttt 36540

ctcatgtcct acgtgaatat gccgaagatt tcattggtat ccaagaaacc cgctatctgc 36600

tcgaacagat ggaaggaggc tatggcgaat taattaaaga agtacaaaga atcgttccct 36660

tacaacgaat gaccgaaata ttacaacgat tagttggaga agatatttct atccgtaata 36720

tgcgatctat tcttgaagct atggtggaat ggggacaaaa agagaaagac gtcgttcaac 36780

tcacagaata tatccgcagt agtctaaaac gttatatctg ctacaaatac gctaatggca 36840

acaatatatt gccggcttat cttttcgatc aagaagtaga agaaaaaatt cgtagcggtg 36900

tgcgccaaac cagtgcaggg agttatttgg cattggagcc tgctgttacc gagagtttac 36960

ttgaacaagt tcgcaagact attggcgatc tatcgcaaat ccagagtaaa ccggtgctga 37020

ttgtttctat ggatattcgt cgctatgtgc gcaaactgat tgagagcgaa tactatggct 37080

tgccggtact ttcataccaa gagctgactc agcagattaa tatccaacca cttggacgaa 37140

tttgcttatg atggcagatc ctttaattcc gtggcttacc gaacatggct tggtttgcca 37200

ccctcatact ttgtctggca cccccatttc tttaggttcg gcctttcaat tagctggcct 37260

caagcttgcc tggcgcgtag aaattgaaca aaggcgggtt tggatcgtgc ttatccaacg 37320

agtggaacaa cgtcgagggc tgaaaaatcc cttcgcggca ctttatatgt tagctaatgc 37380

agcgcgggcc gttcttggcc ctgactatta tctgtatggc aatgtcgatg tactggcggg 37440

gagttctctc agtacgcaac ggctcgctca tttttatcgg cgttggaccg gggccaaaga 37500

attaagcacc gggtggttct cactaaaagt atcacaagtc atcaccttat ctaatatgaa 37560

aaagcgacaa aacaacggct ttgcctgaca agctaaataa aaataacgta atagaatagg 37620

aggtagatta tgaagtcttc ccattttgat gaatatgaca aaacgcttaa acaggcagaa 37680

ctggcaatag ccgacagcga tcaccgcgca aaattattgc aagaaatgtg tgctgatatc 37740

ggcttaacgc ctgaagccgt aatgaagata tttgcgggcc gttccgccga agagataaag 37800

ccagcggagc gcgagttgct tgatgaaatt aagcgtcaga gggagaggca gcctcaacat 37860

ccctacgatg ggaagagacc aagaaaacca acgatgatgc gagggcaaat tatttaatat 37920

gattagagcc tacgaacaaa acccacaaca ttttattgag gatctagaaa aagttagggt 37980

ggaacaactt actggtcatg gttcttcagt tttagaagaa ttggttcagt tagtcaaaga 38040

taaaaatata gatatttcca ttaaatatga tcccagaaaa gattcggagg tttttgccaa 38100

tagagtaatt actgatgata tcgaattgct caagaaaatc ctagcttatt ttctacccga 38160

ggatgccatt cttaaaggcg gtcattatga caaccaactg caaaatggca tcaagcgagt 38220

aaaagagttc cttgaatcat cgccgaatac acaatgggaa ttgcgggcgt tcatggcagt 38280

aatgcatttc tctttaaccg ccgatcgtat cgatgatgat attttgaaag tgattgttga 38340

ttcaatgaat catcatggtg atgcccgtag caagttgcgt gaagaattag ctgagcttac 38400

cgccgaatta aagatttatt cagttattca agccgaaatt aataagcatc tgtctagtag 38460

tggcaccata aatatccatg ataaatccat taatctcatg gataaaaatt tatatggtta 38520

tacagatgaa gagattttta aagccagcgc agagtacaaa attctcgaga aaatgcctca 38580

aaccaccatt caggtggatg ggagcgagaa aaaaatagtc tcgataaagg actttcttgg 38640

aagtgagaat aaaagaaccg gggcgttggg taatctgaaa aactcatact cttataataa 38700

agataataat gaattatctc actttgccac cacctgctcg gataagtcca ggccgctcaa 38760

cgacttggtt agccaaaaaa caactcagct gtctgatatt acatcacgtt ttaattcagc 38820

tattgaagca ctgaaccgtt tcattcagaa atatgattca gtgatgcaac gtctgctaga 38880

tgacacgtct ggtaaatgac acgaggtaat tatgcaacaa gagacgacag acactcaaga 38940

ataccagctg gcaatggaat ccttcctaaa aggaggggga actatcgcca tgctcaacga 39000

aatttcaagt gacactttag agcaactcta ctctcttgca tttaaccaat accagtcagg 39060

aaaatacgag gatgctcaca aggtctttca agctctctgt gtgctagacc actatgattc 39120

acgtttcttt ttagggctag gcgcttgtcg tcaagccatg gggcaatacg acttagcgat 39180

tcatagctac agctatggcg ccataatgga tataaaagaa cctcgttttc cgtttcatgc 39240

ggccgaatgt ttactgcaaa agggagagct tgctgaagca gaaagtggct tgttcttggc 39300

tcaagagctt atcgcagaca aaactgagtt taaggagctt tccacccgag ttagctcaat 39360

gttagaagca attaaattga aaaaggagat ggaacatgag tgcgttgata acccatgacc 39420

gctcaacgcc agtaactgga agtctacttc cctacgtcga gacaccagcg cccgcccccc 39480

ttcagaccca acaagtcgcg ggagaactga aggataaaaa tggcggggtg agttctcagg 39540

gcgtacagct ccctgcacca ctagcagtgg ttgccagcca agttactgaa ggacaacagc 39600

aagaagtcac taaattattg gagtcggtca cccgcggcgc ggcaggatct caactgatat 39660

caaattatgt ttcagtgcta acgaagttta cgcttgcttc acctgataca tttgagattg 39720

agttaggtaa gctagtttct aatttagaag aagtacgcaa agacataaaa atcgctgata 39780

ttcagcgtct tcatgaacaa aacatgaaga aaattgaaga gaatcaagag aaaatcaaag 39840

aaacagaaga gaatgccaag caagtcaaga aatccggcat cgcatcaaag atttttggct 39900

ggctcagcgc catagcctca gtgattgtcg gtgccatcat ggtggcctca ggggtaggag 39960

ccgttgccgg tgcaatgatg gttgcctcag gcgtaattgg gatggcgaat atggcagtga 40020

aacaagcggc ggaagatggc ctgatatccc aagaggcaat gaaaatatta gggccgatac 40080

tcactgcgat tgaagtcgca ttgactgtag tttcaaccgt aatgaccttt ggcggttcgg 40140

cactaaaatg cctggctaat attggcgcaa aactcggtgc taacaccgca agtcttgtgg 40200

ctaaaggagc cgagttttcg gccaaagttg cccaaatttc gacaggcata tcaaacactg 40260

tcgggagtgc agtgactaaa ttagggggca gttttgctgg tttaacaatg agccatgcaa 40320

tccgtacagg atcacaggca acacaagtcg ccgttggtgt gggcagcgga ataactcaga 40380

ccatcaataa taaaaagcaa gctgatttac aacataataa cgctgatttg gccttgaaca 40440

aggcagacat ggcagcgtta caaagtatta ttgaccgact caaagaagag ttatcccatt 40500

tgtcagagtc acatcaacaa gtgatggaac tgattttcca gatgattaat gcaaaaggtg 40560

acatgctgca taatttggcc ggcagacccc atactgttta agtttaagga ggaataacca 40620

tgacaataaa tatcaagaca gacagcccaa ttatcacgac cggttcacag cttgatgcca 40680

tcactacaga gacagtcaag caaagcggtg agattaaaaa aacagaagac acccgtcatg 40740

aagcacaagc aataaagagt agcgaggcaa gcttatctcg gtcacaggtg ccagaattga 40800

tcaaaccgag ccagggaatc aatgttgcat tactgagtaa aagccagggt gatcttaatg 40860

gtactttaag tatcttgttg ttgctgttgg aactggcacg taaagcgcga gaaatgggtt 40920

tgcaacaaag ggatatagaa aataaagcta ctattactgc ccaaaaggag caggtagcgg 40980

agatggtcag cggtgcaaaa ctgatgatcg ccatggcggt ggtgtctggc atcatggctg 41040

ctacttctac ggttgctagt gctttttcta tagcgaaaga ggtgaaaata gttaaacagg 41100

aacaaattct aaacagtaat attgctggcc gcgaacaact tattgataca aaaatgcagc 41160

aaatgagtaa cattggtgat aaagcggtaa gcagagagga tatcgggaga atatggaaac 41220

cagagcaggt agcggatcaa aataagctgg cattattgga taaagaattc agaatgaccg 41280

actcaaaagc caatgcgttt aatgccgcaa cgcagccgtt aggacaaatg gcaaacagtg 41340

cgattcaagt tcatcaaggg tattctcaag ccgaggtcaa agagaaagaa gtcaatgcaa 41400

gtattgctgc caacgagaag caaaaagccg aagaggcgat gaactataat gataacttta 41460

tgaaagatgt cctgcgcttg attgaacaat atgttagcag tcatactcac gccatgaaag 41520

ccgcttttgg tgttgtctga ccattgatga ccttggttag ttaattaacc gaaagtttta 41580

ttttacctta ccccttatgg tgatagagct tatctatata aggtataagg tgctgaaaag 41640

ccctgtatta acattagtta atccagggtt gtgattatta aattaaaaat aataagttag 41700

gatcatatga caattaaaat aaaagattat ttacatgtag tagctcaaga cctgagctga 41760

cagttaccgg ttgttgaacg gcaatacgcg gtcattgagc acgtcagcgg ctgtgatcgg 41820

cattttgctc gtatacagcg agagtgttag aaatgctgtg tcattccagt aatatgcaat 41880

caaaaaagaa tgacacatat cccaataatg agagtcggtg attttactca ttgatggggg 41940

ggaataatta ggctaaaaca acctcaatgt taaagagccg aggtgttcgg taagctctgc 42000

atttaacgct gtttcgacgg taagctttgt tagcatacga gaaaatgcat taaggtcggc 42060

ttcggtttta agacctttag ccagttcagc cgcaagtgct ttaagtttct tttcgtccat 42120

aatttgcctg tctccgttgt tggagtgaag atatcaaaaa caggcaatta cacaatattg 42180

tttacagtct cgattcataa aggtagatcc ttcccgcact caatattcag gttcgtcacg 42240

gcgtaaccaa atatcaaatt gacctttatt cagtcgttgc aatgtttcaa atccctgaag 42300

cgttgaccag gcacggtttg gccgtttgaa atccccggcc gcgtttacca attttttgat 42360

gggggcatgg tcagactcga tacgattatt caggtatttg acttgccgct gctttgcagc 42420

atcccgtatc ttttccttct ttcatcaaac gagtgatagc gtaaccgtat gacgaatgtt 42480

tatcggtatt gagtatttta ggctgtcttt caacagaata gggttttaac acccgtttaa 42540

tgaatggata ggcggtattt ttatttcgtt taggcgaaaa ataaaaatct aatgtagtgc 42600

cgtgcttatt gatggcgcga tagagataaa accattttcc gttgaccctg atatagattt 42660

catcgagttg ccatgaggag tcggcatccg taaattgata tcgtttcaat ttctgacgag 42720

gtataggtgc atattcaata aactaacggt aaatggtaga gcgataaacg gaaatcccac 42780

gctctgacag catatcgctg acattggcat aactcatcgg gggcaaaatg ttcccacttg 42840

aaatcacctg gggccatgtg gattcactga agaagggatg aatagcctca gttttcatga 42900

caactccatt ttttgcaaca agcccaaata tagtgatgct gaagtggcac aaacgctgga 42960

taccgcgcaa aagcacaccc tgacggtttc aaaaggggta ctggatacgg ccaaacagta 43020

tactaacacc gtcagcagta atacattgga cagtgccaat acctatacca ataataaagc 43080

agactaacat tgaaggatgc taataattat actgttcaga aggtaaacag agatgctata 43140

agtggtgtta tagatcagga attatattga gaaaccattg aagaaactaa agagcaaatg 43200

gccggtattg aaactactgc cccaaaatac actgatttaa agtttaatga tatttccggt 43260

aaggttgact ctgcggccat acaatacttc tgacatattt cttctggtta tttatgcata 43320

aaaatggcca aaaactttca atggtagaag agctaaattc ggataaataa cgcataaaaa 43380

ttcccggcga aaaactatat acatatataa atttaatatg tatgtttttg tttgcagtga 43440

aaaactcgat aataaaaata ttttcagaaa ggcattcaat atgttcataa atccaagaaa 43500

tgtatctaat acttttttgc aagaaccatt acgtcattct tctaatttaa ctgagatgcc 43560

ggttgaggca gaaaatgtta aatctaagac tgaatattat aatgcatggt cggaatggga 43620

acgaaatgcc cctccgggga atggtgaaca gagggaaatg gcggtttcaa ggttacgaga 43680

ttgcctggac cgacaagccc atgagctaga actaaataat ctggggctga gttctttgcc 43740

ggaattacct ccgcatttag agagtttagt ggcgtcatgt aattctctta cagaattacc 43800

ggaattaccg cagagcctga aatcacttct agttgataat aacaatctga aggcattatc 43860

cgatttacca cctttactgg aatatttagg tgtctctaat aatcagctgg aaaaattgcc 43920

agagttgcaa aactcgtcct tcttgaaaat tattgatgtt gataacaatt cactgaaaaa 43980

actacctgat ttacctcctt cactggagtt tattgctgct ggtaataatc agctggaaga 44040

attgccagag ttgcaaaact tgcccttctt gactgcgatt tatgctgata acaattcact 44100

gaaaaaacta cctgatttac ctctttcact ggaatctatt gttgctggta ataatattct 44160

ggaagaattg ccagagttgc aaaacttgcc cttcttgact acgatttatg ctgataacaa 44220

tttactgaaa acattacccg atttaccccc ttccctggaa gcacttaatg tcagagataa 44280

ttatttaact gatctgccag aattaccgca gagtttaacc ttcttagatg tttctgaaaa 44340

tattttttct ggattatcgg aattgccacc aaacttgtat tatctcaatg catccagcaa 44400

tgaaataaga tccttatgcg atttaccccc ttcactggaa gaacttaatg tcagtaataa 44460

taagttgatc gaactgccag cgttacctcc acgcttagaa cgtttaatcg cttcatttaa 44520

tcatcttgct gaagtacctg aattgccgca aaacctgaaa cagctccacg tagagtacaa 44580

ccctctgaga gagtttcccg atatacctga gtcagtggaa gatcttcgga tgaactctga 44640

acgtgtagtt gatccatatg aatttgctca tgagactaca gacaaacttg aagatgatgt 44700

atttgagtag tacgcaagag cgttcataat tctgcgtcac gttaaaatat cattacaacg 44760

taatcacttt atcgaggcga ccttcaaaat aaatcgccaa ctgtgacaat gccaaattcc 44820

agctctggat tggcattgtc catctttcct gcgcattcat taatcccaga tacagtgatt 44880

tcaacagact gttctcatta gggaaaatgc ctttcgtttt tgtcagcttt ctgaacagcc 44940

gatgtaccga ttcaatggca tttgtcatgt aaatgacctt gcggatcgtt gtcggatacc 45000

ggaagtaaca cgacaaattg gcccattttt tccgccacga ctggagtacc actggatatt 45060

gttggcccca ttaccagttg aggctcaaaa gttccattgc gatcacgggg cgtggcgagt 45120

tcaaacgtac cagtgggagt tttgaccgtt tttctggacg aaccattttt gcggttggct 45180

tcgatgtcca gagccagatg agtctgacca tgcccccatc aaaaaattgg taaacgcggc 45240

cggggatttc aaacggccaa accgtgcctg gtcaacgctt cagggatttg aaacattgcg 45300

acgactgaat aaaggtcaat ttgatatttg gttacgccgt gacgaacctg aatatcgagt 45360

gcgggaagga tctaccttta tgaatcggct ctttaacatt gaggttgttt tagcctaatt 45420

attccccccc atcaatgagt aaaataccga ctctcattat ttgcagcaaa cctatatatt 45480

gcgctgaatc atagatcacc catcataact ggggataaaa ccacttaata tgttgtaacc 45540

ccacggtttc atatgagtat tctccgatta catatatgtt agttgccatg gataatccgt 45600

aatgttaaat agagttattt tctgtgtcac aatcataaat aacacaattg ttctttcaga 45660

actcaacatt ttaatatact gtagcaatgg tatcaatagt catacttatt aaaatgatat 45720

tttcctcaca gttaattaca cagcgtgaag taatgatatg gtgtttattt tgttattaaa 45780

tgtcgtatct tgtttaatgg ttttatttat gtgtttaact gatttcaatg taaaaaatat 45840

tttttacatt tagtaagtca tgtcaatgat atttgataaa gataattact gcttaattga 45900

tggatatttt ttgttttttt aatcaacggt ggcgtcgcta tcgtcttaac gttcacagaa 45960

gatatcattc tgcatagctc cgccagcatc caggcaagca tctactgtca gaaagtgctc 46020

aactttcata ccagcataaa aagcagcgca caatgcggtg gctatcacta gtcgtttttt 46080

cattgcatag tcctcgtagg ttagattatg ccccatgagc tgagaagagt gagctatcgt 46140

tgtcttgagc tttctgtccg gggtatcatc gaattttact ttatttacat agaatttata 46200

ttctatcata ccataattaa actttacttg aataaaaaca tcggtgtgct gaccatattc 46260

ctgatatgaa tataataata tagccttaat gctcatggta ataaagtgcc ctacagcaat 46320

ttcggcgggt ttgctgcaaa taatgagagt cgtgatttta ctcattgatg gggggggaat 46380

aattaggcta aaacaacctc aatgttaaag agccgattca taaaggtaga tccttcccgc 46440

actcgatatt taggttcgtc acggcgtaac caaatatcaa attgaccttt attcagtcgt 46500

cgcaatgttt aaaatccctg aagcgttgac caggcacggt ttggccgttt gaaatccccg 46560

gccgcgttta ccaatttttt gatgggggca tggtcagact caatacgatt attcaggtat 46620

ttgacttgcc gctgctttgc agcatcccgt atcttttcct tctttcagtt ttcatgacaa 46680

ctccattttt tgcaacaagc ccatagtggg gacaatgaac attaacgccg atcatgagaa 46740

aaacttaaaa gtgagcatta tatataaaat tcaactaatt ggaggaatca ccgaaatact 46800

taatggtggg gttattaact gggggatatt taacttggta ggatatttca aatcgtctat 46860

atcactaata aaaataataa ttattgataa cactaatttg gtcatgttat atgtaaaaat 46920

ttggataaat aatgaaaact tcttaattta tagtgaatta aaaacaaatg agttattata 46980

taaaccatat ctattaaatt taatagatat tattgtaact atgtagtgaa ataactttgt 47040

atggtaccgc gtatatgatt gtttacattt cagatgaata atatgggtga tgtcgagttg 47100

ggctgaaact tagtattttg cggttctttt ctctgctcaa tatcatcaat gaaacgttct 47160

aaccaagcct gcatttcatc gatatccaac cctaccagtg attgttgaga ccagagaata 47220

ggtttaccgt ccagtcttcc ttgaacatgg gcaggccaat gttcgccaaa caaattatcg 47280

ttggttggca aatcagcacc tagctcactg aacaactgta cccattgttg atgataacaa 47340

gcaatcagta cttggatgtg cccatccact tcaaatgtaa atgtataaac gtcattttca 47400

ttaacttgat ggttcaagcc aagcttcagg aaaagctgtt gcataagttc tgtgaaggtt 47460

gtctgcatta aacctccttg gagtcaaatg ttaacactct aaaacgctgc cccaccccca 47520

gaggataatg atacatagaa ttaccccaga atgagttagt aaaccatttg cggaactttt 47580

ccttatcaga aaagtggaat tcaccgaaat tgggatcgaa gaaagtaaca ccactctttt 47640

cgttgacata cgccgctatg gcgtgggctg acatttggcc tgagagatgt atttttttat 47700

aaccgtaacc tatcccatga gtatcaagga tagcgtttaa taattgatcc agcccttctg 47760

attccgtcgt accagtaaca tcaactggac gcagtaagca atgccgttca atcatacgtt 47820

ctgatatgcc atttttcttg aaccaatcta gtgttacctc atcttgatca acgtctgctt 47880

tacaaccatc tatttgcaac tgtttaattg agtaaagtgt atcgatctgg aatttcccct 47940

tacgcccgcc aacatagagc tggtcaaata agctttggcc ttgtgcatgg ctcctgatcc 48000

aatgtgcaca taaagcctca cagacaccgc tagcagtgtc tgaatgtttt attattttat 48060

gaagaaaagc ccctttggtc tgagcaaact tgaaattgat gttacctccg taatttgcaa 48120

cagactctct caccgcgggc acacgagtgc tgagtacaaa atgtatcatg cgatacataa 48180

tcatactgaa ggtaaagctg ctgcgttggt tagctttgcc gtcgctggtc aactttctat 48240

ccagcataga acggcctgac tggttatgtt ttatggtggc tgataacttt ttctgcaggt 48300

ttgagtgtga cagtgctgtt tccactttca ctcggtgtgc gccaatcacc ccttcggtga 48360

gggtagctga ttgaaggttt tcaccggcag aataattcga tagttgaata tggtagtgtc 48420

cgtgaatact gttcatctgt ataacctatt tatgttagcc attattttgc tataccgata 48480

aattgaatat atctggattt tgacgtctgg caatgaacga tagagcctac aataaattat 48540

aaccaatagg tgactcaggg attttctctg aatcagagta catgttgtac attcgattaa 48600

atattttttc aatagttaaa agttactttt tattataaaa attcaactta tggggacagt 48660

gatgttatgt tgatagcgtc ggggcgtcgc ggggagagtt tataataaac tctaatgtga 48720

taaaaatcca ttctaataat gatatattat actatatctg tagctttaaa ataaataatt 48780

atagagtgga ggatgcttga aatatttcga tgcatgggaa gctcattgag agtagatatt 48840

ctatttttat aaattacgga gtgattttaa ttatacactc gtagtgacgg ttattaaata 48900

gtgtagttta taaagtaaat ttgggagtag taactatgtt tattaaagat acttataaca 48960

tgcgtgcttt atgtaccgct cttgaacagt cggctcctga tacaataata aatacatcta 49020

aagaagaaaa taacagttac tactgcgcta ctgctcattt actgagaacg gatgtttgtt 49080

cattggtcaa tagagtaggg attgaaccac ttaaaagtgg atcaatatta tctactttag 49140

aagagttatg gcaggctgtt ggtatagtat atcgcttata cgaatggcaa catgtcagcg 49200

atattgacac caattttaag aaactaccca ataattctga ttttggtctt gtgttttctg 49260

tattagattg tgatatagag tatgtgttca tagggaaaaa agacagtgaa gggaatatag 49320

aattttatga tccgaaaaac tctctactta tagagaatga tgacataaaa aaatatttat 49380

atgatgaaga ttttcatcgt ttttgtatta tgctgatcat ctctaaatct gagttggagg 49440

aattgagtcg cgaatcctgc gatcaagaat gtattatggg atgaagctat attaaagagt 49500

ttgggatatg gtagttgatt atgttaaagg ttaattatct gtaacatata aaaaacagtg 49560

gtatgtaatc atcctgcata atcgtaccat tcatatttag agatcttccg gcatactgac 49620

cttgccaatg aaggagatcg ctaaacgggt acaccgtatc tattgcctcc tgaaactcaa 49680

tattcgccgc aaagggaaac aacgcctgcc agcctgtaac ccatcaccgc tggcggtacc 49740

ggaacgactt aacctgagcg ggtcggtcga ttttatgcac aatgcacaat gcacaatgca 49800

ctgagcggtg ggtgtcattt cagtacgtta taatgtcatg gatgattaca atcgtgaagc 49860

actggcgatt gtaatcgatc tgaacctgcc aacacagcgc cgtcatcaga gtactggatc 49920

gcattgtggt caaccgtggc tatgggaggt gccatgccct gttttaaatg gaagatgata 49980

tgaagaaaaa catgaagtta atagcaatga ctgccgtact gtcctcagta ttagtcctct 50040

ccggctgtgg tgcgatgagc acagcaatca aaaaaacgta atctggaagt gaaaacgcag 50100

atgagtgaaa cgatctggtt agagccgtct tcacagaaaa ccgtttatct acagataaaa 50160

aatatctcag ataaaaatat gcttggctta gccccccaaa tcacaaaagc tgtgcaggat 50220

aaggggtata ccgtaacatc ttccccagaa gatgcacatt actggatcca ggctaatgtc 50280

ctgaaagccg ataaaatgga tttgcgtgaa gctgaaggat ttctgagtca ggggtatcag 50340

ggtgctgcgc tgggggccgc attaggggct ggtattacag gctacaactc taactcagcg 50400

ggagccacgt taggaattgg attggcggct ggtcttgttg ggatggccgc gaatgcgatg 50460

gtcgaggaca tcaattatac tatggtgacg gatgtccaga tttccgagaa aacggacacc 50520

accctacaga ctgacaatgt ggcggcgctg aagcaaggca cctctggcta taaagttcag 50580

accagcacac agacgggcaa caaacatcaa taccagactc gcgtggtttc ttcggctaac 50640

aaggtcaacc tgaaatttga agaagcccgg ccggttctgg aagaccagct agcgaagtct 50700

atcgctaata tcctgtaagc cataagcatc ctggtatgaa gatgtactgg gatgtagtgg 50760

atcagtaata ctggacacct caatagcctg ttaatttaat gacagccaat tgaggtaatt 50820

gataatgact caacctaaac agaccaaacg ccgtttttct cctgaattca aactggaagc 50880

tattgagcag gtcgttaagt atcagcggtc aaccatcgag gttgcacgcg ctctggagct 50940

ggatcccagc caattgcgta aatggatacg ccagtacaaa gaagaagtca gcgggatgac 51000

gccggacaat cctgcactga caccagagca acgtgaaatc cagtcgctca gggcgcagat 51060

taaacggctg gaaatggaaa aagaaatact aaagcaggca gctgtgttga tgagcgagtt 51120

ccccatcaaa tctttgcgtt aacacggctg aaaacaaaat ggccagtggt cgaattgtgc 51180

cgcctgctca aaataacgcg cagtgtttac tctgcttcgc tgaattttcg ggttgatgta 51240

aaacgtctgc aactgcgtga attgcatcaa cagagccggg gagcagccgg cagcagaaca 51300

ctgagtctgc tgatgcgtca gtcgggttat aacgtggtgc gctggctggc ccgcaggctg 51360

atgcgggaat gtggtctggc gagtcgccaa cccggaaaac ctcgttaccg tggcgaacgg 51420

gaggtgtcac tggcatcgcc agatttactg aaaaggcagt ttaagccgtc ggagcccaat 51480

cgtgtgtgga gtggatatat cagctatatc aaagtcaatg gtggctggtg ctacctggca 51540

ctggtgattg acctttactc ccgtcggata gtgggcagtg ccatatcgtc atccccggat 51600

gctgagctgg tgtgtcgagc ctagcgtaat gcactggaga cgcgcccaag ggaaaagagg 51660

ctgctgtttc attcggatca gggagggcag tacaggagta agaaatccag gcagttactg 51720

tggaggaccg gagtgatgca gagtatgagc cgcaggggta actgcctgga taactcacca 51780

atggaaagag tgttccgaag cctgaaaagt gaatggctgc ttgtaggggg ctatatggat 51840

gtccatcatg cggtacgaga tatcggtgaa tggatacaaa gttattacaa caccccccca 51900

tcggcacaat ggtggattac cgccctgtga atacgaagag cggtggaaaa aggctacgaa 51960

ggtgtcctga ttttgtgatc cactacacta cattcaggag agttggacca gaaatcaggt 52020

aataaggtcc ggtccactcg ccttcaaatt caacatgtaa ttcattgtca aacagtcccc 52080

agagcagtaa aacagagatc cggttcaacc tcatacgccg tgccctcggc catgatgcgg 52140

gcaatcgata cccactttgc ggcgttcagg ctcttgggca aagcgacaga actgctccca 52200

gttgcacgta tcgcggatcc cctcggggga acatttgtca gccagtcttc ctggctagaa 52260

tgtgtttaga ttatccgtgg tgattcagtg gttgcacggt atcaagcaaa aaccaaggac 52320

actcttagtt tgaaaaggca ggtaatatac agcttcagtt aacccatttt actgactgat 52380

atttatcgtt ttttgtagca agacgagtgt tttcgattat gtacgtatag gataaatttt 52440

tagtacctat atattggcat gccctgctgt taccgacgag caaaaagaaa ggtcatctac 52500

agcagattag gtaactgtca aacttggggt atttcccata gtcgtcatat agacggaaat 52560

gtgaacgtgc ccagttcggc attgaggctc ttacgcttca tcgcgatgct tggtcactgg 52620

ctgcggcgaa cgttgatatt ctatttatat atctttgcgt tatttgggtt gttttgcgta 52680

ttttttgatg ttttactata aagacgcaaa tttcatagag ataatacata tggacctaaa 52740

gtcaactctt gaccgctgta ttgaacgtgg acagttcatg actcaagaaa ttgctaaatc 52800

acaattcggt aatgacagtc cggctgctcg aacgattact agacgctggc gtattactga 52860

agctgctgaa cttgtcggag taacaccaca aacgatccgt aactatgaag actcaggcaa 52920

actgccaccg cctgatacag caatgattgg tcgtgttgag caacgaactg gatattccat 52980

ccagcaaatt aatgatatgc gtgatgtgtt taaaacaaga ctatccaaac caaaaggcga 53040

aaatcctgtt gttcttgcca ttgcagctca taaaggtggt gcatacaaga catcgacatc 53100

tgttcatatt gctcaatgga tggcgttaca agggttacgg gttttgttga ttgatgcgac 53160

tgatcctcaa gctacggcct ctttatatca tggctatgtt cccgatctgc atatacatga 53220

agaagatact ttgttgcctt attatcttgg tcaacgagat gatgctgctt atgcgataaa 53280

accgacttgc tggccaaatc ttgaagtcat tccttcttgt ctggcagtgc atcgtattga 53340

gtcggaaatt tatggcttgc atgatcaggg gaaattacct gtagcccctc atcttttatt 53400

acgtgctgct attgagtcag tctgggatag ttatgatgtt gtggtgttag atagtgcacc 53460

aaacttaggt attgggacta ttaatgtcgt gtgcgctgct gatgtcatcg tagtgcctac 53520

tccggcggag ctttatgact atgtttccac gttgcaattt ttcaccatgc ttagggattt 53580

gatgtcaaat attgatctca acggttttga acctgatgtg cgcgttttaa ttactaaatt 53640

tagtaatgcg atcggtagtc agtctcagtg gatggacgat cagataagga atgcatgggg 53700

tggaatggtg ttgaaagaag ttgttcgcgt gactgacgaa gtggggaaag gccaagtacg 53760

aatgcgtact gtatttgaac aggcagctaa ccagcgttca acgccagctg cttggcgtaa 53820

cgctgtttcg atttgggagc ctgtttgtgc agaaatattc aatcggctgg ttaagcctcg 53880

ttgggagaat gcatgatgaa aaggtcacca gtgttacgta atgcgccttc aattaatttt 53940

gatgatgcta aacccgcaat cagcaatgca gagccctcgg tttctgctcc ggcggtgagt 54000

cagcttgctt ctcgagttag tggcatgaaa ggcaacacaa tcgtattacc tgtttgtgga 54060

aggaacgttg cttttacgct taaagtgata gcagcacctg atgttgaatc taaaacaatc 54120

gtttttagtg gtaatgagcg aaaccaagca ttattaagtg agacgtcgtt agatgacttg 54180

atcccttcat ttttaacgtc agggcagcag atccccgcct ttgcacgtga acataacggg 54240

aacatcgagg ttgctgatgg aagtcgccga cgtaaagccg cgatactcac cggaagtgac 54300

tataaggttc tggttggtaa cttgaatgat gagcagatgc tatggctgtc ccaaattgct 54360

aatgagtatc gtccgacgag tgcttatgaa cgaggcctgc gttacgccca acggctaata 54420

tctgaatttg aaggtaatat tagtaaattg gcagaggccg agcatctctc tcgcaaaatt 54480

attcagcgtt gtattaaaac ggctgggctg ccccttaaaa ctattcaact gtttgctaac 54540

cctaatgaat taagtgctcg tagtggcgaa gcattaagta aagcttatga aaataatgtt 54600

gatacgctaa agcgagttac gcataaaatt atgaagcaaa aacaggaagg tcgccagttt 54660

actacggaag aattaatcgt attgctgatg cctgagagaa aacagccaga gaacattcat 54720

aaaaaaagct ttggcaaaaa tatagaagca aaatattcaa aagacaatgt ttctttctat 54780

ctcaaatctg tgccagagtc cttggttaaa caaatagaag aactcttgaa tacctatgca 54840

aaggaacatt ctttgtagtg cctgaataag atcagaacaa ggtgggttgt ctgcccgcct 54900

ttatttagtg tatatctatt gttttagctc atccttcgta gaagatctcc ttctttacaa 54960

ctcatttcct aagctgaact gtggccccaa tcaccaacgt tagcattgga tatccaggtg 55020

ggaccgtggt cccaattact aacgttggca ttggatatcc aggtgggacc gtggtcccaa 55080

ttaccaacgt tggcattgga tatccaggtg ggaccgtggt cccaattacc aacgttgaca 55140

ttggatatcc aggtgggacc gtggtcccaa ttaccaacgt tggcattgga tatccaagtg 55200

ggaccgtggt cccaattact aacactggca ttgaacatcc tagtggaaat gtgattcgaa 55260

ttgaaagcga ttaagtcgat gagcattttt ttagtgatag ctttagggag attaaactag 55320

cggatatttc attatggaga taataatttt cgcttcattt atcacccctt cgcaatactc 55380

tgttcaccaa gtcatactat tcttagccca gagctattga tgcatcaaca acttgcatca 55440

gatgtttact gttcgcgtgc ggcggtgttt catcaaacat atctatctga cctggtcgac 55500

tgccgacgtc attaagcatg atgtcggctt tttgatagcg atatccatcc cgccaggttg 55560

gatacggcga tttcatgtta gtatcgatgt aacaatgacg gctctattgc attaaggcac 55620

agtctggtaa catgctgttt tttttatgat attgcctgca catatcttta atcaaaaaat 55680

ttttttgtcg cctgcattac cccatcgatg ttatagctca gtgtgttcac tggtatcttg 55740

gcgatgccct gagttttcta aatctagagg aaatgatgac gaaacacggt atctctgttg 55800

agcattacac actccacagt tgggttattc gtgtggtgcc attactgcat aaagcttttt 55860

gccgttataa atgtaccgtg ggtcgccggt ggcgaatgga tgaagcctca aaggtcagtg 55920

gaaatacctg taccgggcgg ttgatactcg cggttagact atcgattttc tgctgacggt 55980

aaagcaggat gcggcggcag cactgtgccg actggtatca ggtctcccgg taaattcata 56040

tattaaagta ggcagggctg gctcattaca gattgtttag ctataattgt attactcagt 56100

aatacataac ggaggggata tggctcacgt aaccagcgta acacttggag agcatttgac 56160

aggttttgtg ggggaaatga ttcagtctgg tcgttatggc aatatatcag aagtgcttcg 56220

tgatgcctta aggctaatgg aagcacgtga acagcgtgtt caacatgtac gcgatatggt 56280

gcttgcagga acaaatgtac ctgtgagcca tcgtttaatg gatgagattt tttctgctgc 56340

ggtgaaagat actagtgtat aaactgtctg aactagctga tgaggatatt tataatattg 56400

ccagttatac tatccggcat ttcggtgtga ctcaggctaa gttataccat gagaacttgg 56460

caaaggtatt cgagctatta gctaaaaatc cagagttagg ggctgagtgt aactggattt 56520

gctctgatat tcgccgtttt cagtataaaa agcacggtat atactatata acgcttagca 56580

atgatatttt gatttctcga gtgctgcatc aatccataga tatagatgtt caggattttc 56640

cagagcatga gtagtaatac agaagagaga taagtcagaa attctaacaa tgagcatgct 56700

aaaaaacgat tcgcccctga aagatcaggg acgaagatat tcgcaatatt gatagaaaaa 56760

gggggaaaca ctatcccctt gtttttatcc atatcacatc aatgacagta atttctgcat 56820

ctgttgcgcc agccctttga tctcatttgc tgcctgcgtt agatcaacgc cactggcgac 56880

gtacgcgctg gccgccccac caatagttcc ccactgcgag aagggaatac cacaaacagg 56940

cgtgtttaag atggcactgg cctcagcttg caattcccca ccacaaaact gcatcagccc 57000

ttggcattga gtgatactgc cacgaagagg gccgctgccc gtagcgaact gatcatgatt 57060

tttctgcagc atctctgcat ccaagctatt caactgctgc atgtattttg gcagcgtctc 57120

agcagcaagt tgcttgatac tgtcactgaa agacgtagga cttggcattt gtgcaggtgt 57180

gggtgctggt gtcaccaccg gtttatggct cccctccgag aacatgcgtt ggataaaccc 57240

aatcacagag tgggccactg atgataacct ctcaatgata cggctggcta agctggaacc 57300

ctgagggctt tcagtgcgcc cggccagatt gtttgcatat tgatcacttg tttgctgtga 57360

gactgagcgc ccagacattt ctcctacgct gctagatcct gacacagatg tcggcagggg 57420

cagtgatgta gaaataaatg atgatatttt catgactatt tattaccttg gctattaaaa 57480

caaggttatc ttagtgggaa aatagccgat ggctatataa aaaatcgctg ctgtttttgt 57540

tgttatatta gacaaaacaa aaactaaaaa ttataggcta aaattgatgg tctgccgaga 57600

gtgctttggt taagttgata ttttatctaa ctattatgag atcataatgt attcatttga 57660

acaagctatc actcaattat ttcaacaact ttcgttgtct attccagata ctattgaacc 57720

ggttatcggt gtcaaagttg gggaattcgc ctgccatata acagagcatc ctgtcgggca 57780

aatattaatg tttaccctac cttctcttga caataatgat gaaaaggaaa ccttacttag 57840

ccataatata ttcagtcaag atatattaaa acccatctta tcctgggacg aggttggggg 57900

gcacccagtg ttatggaatc gacaaccatt gaacagcctg gataataact cactatatac 57960

tcagcttgag atgctggtgc agggggctga acggctacaa acctcatcac taatctcacc 58020

accacggtca tttagttgag tagatttttg gttgttgcct tattatacgg aatgacctgc 58080

ccccaggatt agatacaacg ctcacttagt aatgtcggat ccttcactat cagaattacc 58140

ctttctccag gccgccgcaa attcagacgg cgtctgataa ttcagcgtag agtgcgggcg 58200

gcactcatta taatcctgac gccattcact gatggttttc ctggcatgac tgacgtcact 58260

gaaccagtgc tcattcaggc attcatcgcg aaagcgtccg ttaaaactct caataaatcc 58320

gttctgtgtc ggcttgccgg gctggataag tcgcagttcc acgccatgct caaaggccca 58380

ttgatcgagc gcgcggcagg taaattccgg gccctgatca gttcttatcg tcgccggata 58440

gccgcgaaac agcgcaatgc tgtccagaat acgcgtgacc tgcacgcctg aaatcccaaa 58500

ggcaacagtg accgtcaggc attccttcgt gtagtcgtcc acgcaggtaa ggcactttat 58560

cctgcgaccg gtggccaatg cgtccatgac gaaatccatc gaccaggtca gattgggcgc 58620

cgccggacgg agcagcggca gacgttctgt tgccagccct ttccgacgcc ttctgcgttt 58680

tacgcccagg ccactgaggt gataaagccg gtacacgcgc ttatgattaa catgaagccc 58740

ttcacggtgt tagcgccagt gatataagac ggtaattcac cattagtatt gtccgctcca 58800

cccaacatgt tgtttccttg aggttctcac accagaaagg acatcaacat gctgagcaga 58860

gaggactttt acatgataaa gcaaatgcgc cagcaggggg cgtacattat cgatattgcg 58920

actcaggtgg gttgctctga acgaactgtc agacgctacc tcaaataccc tgaaccgcca 58980

gccagaaaga ctcgccacaa aatggttaag ctgaaaccgt ttatggacta catcgacatg 59040

cgcctggcag agaatgtctg gaatagcgag gtcatcctcg cggaaattaa ggcgatgggc 59100

tataccggcg ggcgttccat gctgcgttac tacatccagc ccaaacgtaa aatgcggcca 59160

tcaaaaagaa cggttcgcgt cgaaacccag ccgggatatc agctccagca cgactggggc 59220

gaagtcgagc tagaggttgc tgggcaacgg tgtaaagtta acttcgcggt taatacgctg 59280

gggttctccc gacgcttcca tgtcttcgct gcgccaaagc aggatgctga acacacctat 59340

gagtcgctgg tccgtgcctt ccgttacttc ggcggcagtg tgaaaaccgt gctggttgat 59400

aaccagaaag ccgcggtgct gaaaaataac aacggaaaag tggtgttcaa ctccgggttc 59460

ctcttgttgg ccgaacatta tgacttcctg ccacgggcct gccgcccgcg cagggccaga 59520

accaaaggta aggtggagcg gatggtgaaa tatcttaagg ataacgtctt cgtccggtac 59580

cgcaggttcg acagcttcac ccatgttaac caacagctgg agcagtggat ggcggatgtt 59640

gctgataaac gcgagcttcg ccagttcaga caaacaccgg aacagcgctt cgcgctggaa 59700

caggagcatc tgcagccgtt gccggatacg gacttcgata ccagctactt cgacatccgc 59760

catgtgtcct gggacagcta tatcgaggtt ggcggcaatc gttacagtgt tcccgaggct 59820

ctgtgcgggc aaccagtctc gatacgtata tcgctggatg acgagctgcg gagctacagt 59880

aatgagcagc aggtggcctc acatcgactc tgttcagcat cgtctggctg gcagactgtg 59940

ccggagcacc acgccccgct ctggcaacag gtcagcatgg tagaacatcg cccactgagt 60000

gcttatgagg agttgctgtg atgcatgaac ttgaagcgct gctgagtcgc ctgaaaatgg 60060

agcacctgag ctatcacgtt gaaagtctgc tggagcaggc ggctaaaaaa gagctgaact 60120

accgggagtt cctgtgcatg gcgctgcaac aggagtggaa cggcagacat cagcgcggca 60180

tggagtcccg actgaagcag gcgcgtctgc cgtgggtcaa aacgctggag cagttcgact 60240

tcaccttcca gccgggcatc gatcgtaagg ttgtccggga gctggccggt ctggcgtttg 60300

tggagcgctg cgagaatgtg atcctgctgg gtcctccagg tgtcgggaaa acccatctgg 60360

ccgttgctct cggcgtgaaa gcagcggatg cagggcatcg ggtactgttc atgccacttt 60420

atgaagacat tactaacatc ggggtgtact aatcaacgag gagcaggtca ggaaatagcg 60480

ataacctata aatttgtggt gccagtaata tcagatttcg ctcagtaaaa gttaacacca 60540

agttggagtg ttgactttta tctcctgttt ttttttaatt tttaatgtaa aagacttgta 60600

ttaagtccat tcacttggtg gcgtcgccgc ctcctcattg gtaatgagga gtaccggaag 60660

agttctcaat gtgaatggtt gagctgtata agtttgttat actttatatc cacggtgata 60720

caacgttggg gtagcatctg ggaaggagag aaataaaaaa attctatatt tttctaattt 60780

taaagggtca gttatatgcg cacttacagt tcattacttg aagaatttgc tacagagcta 60840

ggtcttgaag aaatagaaac aaatgagtta gggcatgggg ctgttaccat tgataaaata 60900

tgggtagtac atctggcacc tatcaatgag aaggagttag tggcttttat gcgggcaggg 60960

atcttgactg gtcagtctca actttatgat attttgcgga aaaacctctt tagcccacta 61020

tctggtgtaa ttcgttgtgc gcttgataaa gatgatcact ggctattgtg gagtcagtta 61080

aacattaatg acaccagtgg gacgcaactg gcgagcgtat tgacgtcgct ggttgataaa 61140

gctgttactc tttcttgtga acccacaatg aagaaagagg aggatgatca tcgtccttca 61200

tcatctcatt tactggttta attctataaa agaaaaacgt acgatatcca ttaatgggtt 61260

tggttgagac tgtaaacaag attgtataat tgcctgtttt tgatatcttt actccaacaa 61320

cggagacagg caaatttgat ccctccccaa tatccgtacc aggctaaatc agagatccgg 61380

acctttttga tgacttcggg caaattctgc cggagtcagg ttatttaacg aagaatgcgg 61440

atgaaaatga ttatattctt gccgccattg ttcaattttc tcctgagcat cttccagaga 61500

aaggaacccg tgcacgttca gacattcatc cctcagactg ccattaaatg actcgataaa 61560

ggcattatct gtaggctttc cggggcgtga acagtccatc gtgaccctgt tttcatacgc 61620

ccatcggtcc atcgacttcg agatgaattc gctgccgtta tctgtctgca gcctttgtgg 61680

aatacgcccc agcgaatgtt ttaatctgtc catgacagcc acaacatcat ctccacgtaa 61740

cccctgaccg acctcgatcg ccagacattc acgactaaaa ttatccacta tagttagcgc 61800

cctgacccga cgcccgttga acagattatc agcaacgaaa tccatgctcc agcactgctc 61860

taacgcggtc acttctggac gtgcgtgcct gtgcttcgct gtcacatgcc gccgtggacg 61920

tttcgaacgt agattgagac cctcaagaca gtaaatacgg tgcgttttct tatggttaac 61980

aagccagcct tctctccgca gcaggatatg aatgcgcgga cagccataac ggatgcgcgt 62040

ctccgcaatt tcccgtattc gctgagtaat agcccgatcg tcacgatggc tacgatagtt 62100

gtatacagtg cggctctgca tcatcagcct gcaccctctg cgtactccga tacggtacgc 62160

cgccagcaga tattccacgg catcacgctt ctgcagcggc ctcagaactt ttttcggatg 62220

acatcctgca gcatttcctt atccagactc agatcggcca ccagacgttt gaggcgctga 62280

ttctcatcct caagctgccg aagacggcgc aattccgtga cacccattcc cccaaacttc 62340

ttcttccagt tgtaaaatgt cgcttccgaa atgcccatct tcctacagac ttcttccact 62400

cgagtacccg tttcagcctg tttgagtgca aaagcgattt gttcttcggt ataacgcgtc 62460

tttttcataa cgaatgaccc ctttttggac ggaaaagaag ggccgaaaac tctactttac 62520

agcggtactg aactaagggg gaagatcaag caatccttgt ttgtcgatta ttttaaattt 62580

gttttgactc ctccaatctt tgattcaata gacacgcatt caatggtttt tattatatca 62640

tcaatgccgg cccagagatt ttcattatta ttgttcttgt aatttgtttt taattgagta 62700

ttcaaactcc tctcaattcg catcacttca tcaatatgtt caagcttaca ctttattaag 62760

tcatccctaa gagaaatatt ttccttctca agtttagata ttcttttctc tagccgagtt 62820

gttatttctt tttcctttct atttttctct ttgttgaaaa ataaatcaaa gtagtatttt 62880

gcaaaaaatg ttaacattac actgagtgtg taaaccagaa attgaatatt tgatggtcat 62940

gtggatttag gaatataaaa cccaaccgaa gccataaaaa tagcgggaat tgcatatgat 63000

aaaaatgtat aaatagtcat ttttatttat ctgctttagt ttacatagtt gtgttctatc 63060

cctttgtctt taaagctatt acttagcttt ttaggggcaa ttctaagaag tcccatagat 63120

gtttctagtt cattggaaaa atttggaata ccctttgagg catcaaacac catgctatat 63180

gtaaactgaa ccgtaagttc ttttctttca acgtctagcg aatttaaact tgccttaatt 63240

ccgagacata ctgagttaaa ggaatttgtt gctttatata ctgaaacttc atttggcttt 63300

ccattgctga aaaagtcaaa gttctcgaaa gtaaaaagat atttaatttc ataaatgttt 63360

aaactgtcag ttgtgaggtc tgaaaaataa taatcacctt caatataggt aaactcacca 63420

ttatttttat caagcatttt tatattctta agagattcca ctttttctaa aatagagtat 63480

aaattattct gcaaattcat tttacgcccc ttagctgttt attgtgattc attgatgact 63540

ttataaatag ttgaacgagc tatattcatt tttttggcta tttctgtcgc gcccatcccc 63600

tgttcatgca attcgagtag ttcctttctg ttgattctgc gctttcgtcc gaatttaacc 63660

ccctttagct tagcctcttc tctcccttca tttgtacgct ccagtattct ctgtcgttcg 63720

gcttgagcca ctgctgatag aatagtgaca accattttac ccatttcccc atcggtactg 63780

attccgtcat caataaactg gatggacaca ccctgggcgt caaactcttt tatcaactgg 63840

atcatgtcga cggtgtcgcg gccaagacgg tcgagcttct tcactagaat gacgtcacct 63900

tcttccacct tcatacgcag cagatccagc ccctccctgt cggcagagct gccggatgcc 63960

ttatcagtaa atatacgatt tgctttcacg cccgcgtctt tgagtgtttt gatctgaata 64020

tcgagggatt gctgactggt tgatacccgc gcgtaaccaa aaagtcgcat aaaaatgtat 64080

cctaaatcaa atatcggaca actggtgtct attataacaa aaaatcgatt aaatagacac 64140

acaaaccgca ccatttcagt gtgtccgaca acttataata tttcggacgg ttaaaaagtt 64200

gttaacaaat aaccgtcagg cagggaggcc tgtatgccag tcgattttct gaccactgag 64260

caagaacaga attacggttg ttacgttgca gaacccaatg acgtgcaact ggtgcgctat 64320

tttcatcttg acgagcggga tcttgctttc atttaccagc ggcggggaaa gcataaccgc 64380

ctgggaatag cacttcagct cacaacggcc cgttttctgg gaacctttat tacggattta 64440

acccaagttc tgccaggtgt tcagcatttt gtcgccgtac agcttaatat acgccgtccg 64500

gaagtcctct cccgctatgc cgagcgtgat accactcgca gggaacatac cgcgcagata 64560

aaggaatatt acggctatca tgaatttggt gattttccgt ggtctttccg cctgaaacgt 64620

ctgctgtaca cccgtgcatg gctcagcaat gaacgccccg gtctgatgtt tgattttgcc 64680

actgcgtggc tgcttcagaa taagattctg ttgcccggag caaccacact tgtacgtctc 64740

gtcagtgaaa tacgcgaaag ggcaaatcag cggctctgga aaaagctggc cgccattcat 64800

tatctgaccg aactaaacgg cacgaaaaaa cgcctcctgg atgatgctcc tgaacatatt 64860

attaccggcc cctggaaacg cctggtgtac gatgcggagg gccggataca acgtgccggt 64920

tactcgcttt gtctgctgga gcgccttcag gatgcattga gacgccggga catctggctg 64980

aaaaatagcg atcgctgggg agatctccgc gagaagttgt tgcaggggga agagtggcag 65040

gctcagcggg tcctcgtctg ccgggcgttg ggacatccca ccgatggaca taaaggcgta 65100

caacagttgg cggtccaact ggatgaaacc tggagagcag ttgcatcccg ctttgaagga 65160

aatacggaag tccatatctg caatgacggt aaatatcctt ccctgactat cagcagtctg 65220

gagaaattgg aggagccact gtcgttgctt cgtctaaaca atcgggtcag gcaactgcta 65280

ccgccggtag atttgacgga actgttgctt gaaatagatg ccagaacggg atttacacgt 65340

gagtttacac atgtcagtga atccggggct cgagcgcaag atctgcacat cagcctgtgc 65400

gcggtactga tggctgaagc ctgcaatatc gggctggaac cgctgataaa gcacaatata 65460

ccggcactga cgcgccaccg gctcagttgg atgaaacaga attaccttca ggcagaaacg 65520

ctggtcagcg ccaatgcccg gttagttgat tttcagtcca cgctggagct tgctcgccgc 65580

tggggtggcg gcgaagtggc ttcagttgac ggtatgcgct ttgtcacgcc agtgaaaacg 65640

gtcaattccg ggccgaacag aaaatatttt ggctccgggc gtggcatcac ctggtacaac 65700

ttcgtctctg atcagtactc tggattccac ggcatcgttg tccccggcac attacgggat 65760

tccatttttg tgctggaagg ccttctggaa cagcagacag ggctgaatcc ggttgagatc 65820

atgacagaca cagccggtac cagcgacatt atatttggcc tgttctggct acttgggtat 65880

cagttttccc cccgtctggc tgatgccggt gaagctgtat tctggcgagt ggataaatcg 65940

gcaaattacg gagcacttga tgagcttgct cgtgggtgtg cagatctgtc gaaggcagaa 66000

aatcagtggg atgagatgat gcgaactgcg ggttcgctca agctgggcac cattcatgct 66060

tcagaactca ttcgctcact actgaaaagc tcacggccgt cagggctggc tcaggccatc 66120

atggcggtgg ggcgtgtaaa caagacgctg tatcttctta attatattga tgatgaagat 66180

tatcgtcgcc ggatcctgac gcaactcaat cggggagaga gccgccatgc cgtggcacgt 66240

gcaatttgtt acgggcagcg cggtgagatc agaaaacgct accgtgaggg gcaggaagat 66300

caactgggcg cattggggct ggtcactaac gcagtggtac tgtggaacac gctttatatg 66360

caggaagcac tgagctggat gcgcagtaat ggagaagaaa ccagggatga ggatatcgcc 66420

cggttatctc cactgatgca cgggcatatc aatatgctgg ggcattatac gttcacgcta 66480

tcggatgata ttttaaacgg agaactgaga gcattaaatt tcaatttaaa caatgaatta 66540

tctccttaac gtacgttttc gtcccattgg acctcaaaac ccatcaccgg gtagccacgg 66600

ttgaccacaa tgcgatccag tactctgatg acgtgctgtg ttggcaggtt cagatcgatt 66660

tcaatcgcca gcttttcacg attgtaatca tccacacaga tcagtgcatc gtgcataaaa 66720

tcgaccgccc cgctcaggtt aagtcgttcc ggcaccgcca gcggtgatgg ggtacgagct 66780

ggcaggcgtt gtttcccttt gcggcgaata ttgagtttca ggagacaata gatacggtgt 66840

acccgtttat ggttccagac atatccccat cgcctcagga tttgaaaaac cttaaagaaa 66900

ccgtcgcgtg gataacgctc gaccactgat ctggtgttca gtgaatcagt ttttttcgca 66960

tggtgaactc ctcaaaatac atattcagta tgtcggaaat tctctaaaag agaatggtta 67020

tttttgatgg tcattacagt acagattatt ttatataatt tattacccac tttttttata 67080

ttttttgata gagggaggat aataaataaa aaaattataa agtaatggtt tcttgctgtt 67140

ttctggtgtt tttctctata tttatgtttt tttggtgaaa ataagtgtgt tgtcaggtaa 67200

tttcaaagga ttatacaaaa tatccggttt gaggtgaggg attttttttt atattatctg 67260

cataacactt ttcgtgttat ctgaaagtat tttgtagtgg gctgactccg acgattcgat 67320

tagagattac aaacgatgca tatattcagt agttaatcga tatcttttta agatcgatta 67380

gtgctgtttt ttgcatgatt atcagaaaat aagtcataga taatcctatc cctcttctat 67440

gggaggcgtt cgctttaatt aatatatttc tcagatgtta taactgagct tttattcacg 67500

ggaaattaaa gaaatataaa aggtgcttac aatgactaaa gattttaaga tcagtgtctc 67560

tgcggcatta atatctgcgt tgttctcatc tccatatgca tttgccgagg agcccgagga 67620

tggcagcgat ggtattcctc gtttgtcagc agttcaaata agcccaaatg ttgatcctaa 67680

attgggtgtg ggattatatc cagcaaaacc aatattacgt caagaaaacc caaaattacc 67740

tccacgaggt ccacaaggtc cagaaaaaaa agagctagat tagcagaagc aatacaacca 67800

caagtactag gcgcaggcgg gctcaatgct cgcgctaagg atccctatag cattgcgatt 67860

ggtgctactg ctgaagcagc aaaaccagca gcaattgctg tgggctctgg ttcaatggca 67920

acaggcgttg attctgttgc aattggtcct ttaagtaagg cattgggaga ttcggcagtt 67980

acttatgggg taagtagtac cgcccagaaa gatggagtag ctatcggtgc gaaagcatca 68040

gcttcggata ctggtgtcgc tgtcggtttt aactcgaaag ttgatgcaca aaactctgtt 68100

gccattggac actctagtca cgttgcggca gatcatggtt attcaattgc aattggggat 68160

cattctaaaa ctgaccgaga gaatagtgta tccattggtc atgaaagcct taatcgccaa 68220

ttaacacatc ttgcggctgg cactgaagac actgatgcag tgaatgtcgc gcaattaaag 68280

aaagaaatgg ctgaaacatt ggaaaatgca cgtaaagaga ctttggctca gtctaacgat 68340

gttttggatg cggccaaaaa acactcaaat agtgttgcca gaacaacttt agaaactgct 68400

gaagaacatg caaataaaaa atcagctgaa acgttagtaa gcgctaaagt gtatgcagac 68460

agcaattctt ctcaaacact aaaaactgca aatagctata ccgatgtgac tgtaagtaat 68520

tcgactaaga aagcaacccg tgaatctaat caatacacag atcataaatt cagtcaactt 68580

gacaaccgtt tagataaact tgacaaacga gttgacaaag gtttagccag ttcagccgct 68640

ttaaacagct tgttccagcc atatggtgta gggaaagtaa actttactgc aggtgtcggg 68700

ggatatcgtt ctagtcaggc attagcaatt ggttctggct atcgtgtaaa tgagagtgtc 68760

gcatttaaag ccggtgtggc ttatgccggt tcctcgaatg tcatgtacaa cgcatcattt 68820

aatatcgagt ggtaatatca tttagaaatt aacaagtcta taggaaaaca ccgattacat 68880

aatcgtaatt ggtgttttat taatatgcta atgaaaaatt ttttagtaat tctgcttttt 68940

atcatggttt cagttacatg gggaactaca tggttagcga tgaaattaac cgtcgaaaca 69000

atctctccga tatttgctac gggcatccga tttatgttgg ctgcgcctgt attaatccta 69060

attacatcaa cccgcaaatt cagcgaagca gagtaaacac tgcgcgttat tttgagcagg 69120

cggcacaatt cgaccactgg ccattttgtt ttcagccgtg ttaacgcaaa gatttgatgg 69180

ggaactcgct catcaacacg gctgcctgct ttagtatttc tttttccatt tccagccgtt 69240

taatctgcgc cctgagcgac tggatttcac gttgctctgg tgtcagtgca ggattgtccg 69300

gcgtcacccc gctgacttct tctttgtact ggcgtatcca tttacgcaat tggctgggat 69360

ccagctccag agcgcgtgca acctcgatgg ttgaccgctg atacttaacg acctgctcaa 69420

tagcttccag tttgaattca ggagaaaaac ggcgttatcc agaacgtgaa gcgatttacg 69480

cggcgctgga gtaaaccaat gggcggcatg gccgcccatt ggtttactta tcagtacgca 69540

gtgccatttt gcggccgcgc gaaaaccctt gtcactctaa gtaacgcgga gggtgagtcg 69600

gtactgattt ctccgcagca gaataccgcg caggatattt ccctgttcat gccccgggaa 69660

ctgacggtca gtcaaggtga tcgggtgcga tttacccgct cagacacaga ccggggttat 69720

gtggccaata gtctgtggga agtggcgggt tttactgaag acggtgctgt gcgttttcgt 69780

cagggcgacc aggaaaagat tgtcgatcca caaaaggcca ccgaagaccg ccatattgac 69840

ctggcctaca cgctgacagc ctatggtgtg caaggggcca gtgagcggtt tgtcatcgcc 69900

ctgtttgggg ctgaaggtgg cagaaagagg atggccactc tgcatctctt tacgtgacat 69960

tgtcacgcgc caaagagcat gtctaggtct atacggacaa cgttgttaaa tggttgggtc 70020

ttgccgggca gtcaaatgcc ggaaaaaccg cgcattgtag tggatcagta ataccggaca 70080

ccctcaatag cctgttaatt taatgacagc caattgaggt aattgataat gactcaacct 70140

aaacagacca aacgccgttt ttctcctgaa ttcaaactgg aagctattga gcaggtcgtt 70200

aagtatcagc ggtcaaccat cgaggttgca cgcgctctgg agctggatcc cagccaattg 70260

cgtaaatgga tacgccagta caaagaagaa gtcagcgggg tgacgccgga caatcctgca 70320

ctgacaccag agcaacgtga aatccagtcg ctcagggcgc agattaaacg gctggaaatg 70380

gaaaaagaaa tactaaagca ggcagccgtg ttgatgagcg agttccccat caaatctttg 70440

cgttaacacg gctgaaaaca aaatggccag tggtcgaatt gtgccgcctg ctcaaaataa 70500

cgcgcagtgt ttactctgct tcgctgaatt ttcgggttga tgtaaaacgt ctgcaactg 70559

2

100990

Yersinia pestis

2

aaacagcccg gcgtgctgga gcgactggaa cgtgaggacg gtgtcattat ccaccagcgt 60

cgcgagtggc gcatgtacga tccggaaaca ggtaagctca cgacgaaggc cggaacgctc 120

tggggtctgc tgaagaaaat ccactgataa caccaaccac tgcggtgagt agccagctca 180

ccgcgcgcgt atctgggtca taaccactgt agtgagtaaa acggctgccg tggcatccgg 240

tatccactgt agtgagtaaa gtggtgatta tcgacttcac tatccactgt agagagtaaa 300

caggcgttca ttcacagcaa acaaccacta tggagagtga tggaatgcga cctccagcgg 360

gtatccacta tggagagtaa accttcactg ttttcagcgg atgtctactc tccacagtgg 420

atagtaaatc cagccaaccg attctgctct ccatagtgga tagccaatag cgaagggagc 480

aacgataacc actatagaga gtggatttaa caagtcaccc agtgaccact aacctcgcag 540

cccttgtttc atctaggttt gtaaccacta acattcattt cgttatttga gcgctactgc 600

ctacagtggt tactattcgg ttgttgttac tcactacagt ggatagcgga cttcagataa 660

acaaaaggcc cactacagcg gaatagtgag cctttctact ctctacagtg attgggctat 720

ttgcgagcct ttgccttgcg cagctcttcg agaatcgcca gttcttcctt gctcaacatg 780

accatctcac cgtctttttc ttcaggaaca acatcgatga tgtcctcctg accatcgcca 840

ggcaagttat cttcctgctc ttctggttct tccggcgcag ctttagttgg tggcaatgcc 900

gggcgtaact tcggccgcct atagtggatg atgaagtaga ccgagctgcc gcgcttcact 960

tcggtgtaat cgagatagcc gatctcccgc agctgctcca tcgccttcct gactgtcgcg 1020

ttctgggtaa tggtgcggct ggttaagtta agtctggcgc gtaagcgagc caacgagatt 1080

ggtgccgggt caggtggcaa actttcgatg aatgtgtaga gtgcctgggc ggattctttt 1140

ctggagagtt cgttgattgc ccggagttgc agaagaacct ttttgtcgaa ctggtagagt 1200

tcgaaaatct taggatcagc ctgcagcgag accgtgtcgt tcttagtgct gtactttgct 1260

gtctgcacaa ggtgagttac gtaatactca tcagagcctt tactgcggaa tgagatagtg 1320

tttgtggcga tacgagttag agaactgtcc aggcgcttac gtaacttcgc ggacgatctg 1380

gccgttggta tgccacagag cctgacgaac tcgacgaacg gtaacgtgac agtgtcgcca 1440

acaaccttgt gcttggcgaa cgcgtggatg atgcctaccc acgttttaaa gtcgttatcc 1500

atatccagac gaacgccgga gatccttatg tcctcatacc cttcggcttt ggccagagac 1560

agctgtttga gttcagcaga ggcgtccata gagaccattt gccccttcct gcccctggac 1620

gtcgatttca gcgtcggaac gaagagacca agacgcatca gagcaacggg ctgaacagtg 1680

ttgttggtgt taggaactaa cgtaacaact tcgcctgtct ttttgtctgt ttctgagaat 1740

gcttcaacga tcgctatgtt tttattgccg ttttcgctca ttccaagtgt ctctttttat 1800

tcgacggctt tggtggcctt tgctgattac agtggatatt agcactcatc acagcggtta 1860

tcctaccgcc tatagtggtt tttctactct ctacagtggt tggtttactc ttcatagtgg 1920

ctgatcttct ctctatagtg gatatcgatc acctctgagg ccagatggca caacggtttg 1980

cgggatgcgg ggatcttttt gggtctttgt gggtctcttt ggttctattt gggatctgaa 2040

ttactggatc gggcctgtgt ataaaaatca ggtaattgca aaaccagcca tcactccctt 2100

tctggggata atgtgtggtg gaaacaaaca cgcctgaacg caagattaac gatatatcca 2160

tgaatatcag ctatctaaca cagaaaaaca ggcaaagagt tatccagtca agacaatgcc 2220

tcctactcac tacagtggat accgaccact ctccagagag gttgttttgc tcttcatagc 2280

ggttattatg ctctctacag aggttacttt gctccccata gtggatagta accccctctc 2340

aggccagtaa ccgcaacggc tggagacgat cggggatctc ttttgatctt ctgtaggatc 2400

tctctgggga tctaattatt ggatcggtcc tgtgaataat gggtataagt aaaacaggca 2460

tttgcaaaca tcggtgcgcc ttgtcagtta tcgttgcccc ggacaaaact atttgaataa 2520

gaattatgga tctcaaacgc acgcgctggg ttcgccgtct tgaagatggc tcctacacca 2580

ttgaatcgaa cactatcctg aacaaacaga aattgctctg cgacctatgc ggcatagcgt 2640

cgaagtgccc gattaacgaa actcggctca aactctacga cgccggtgcg cacttccact 2700

tgaacagctg catacgttac gtgccactgc tggcatttcg taaaccgatc atcggattgg 2760

acgcacccta cttcaacacg ctccgctctg gtgtaacatg gcgagaccgg gtcgaacctg 2820

gcaagctcgt ttgtctggtt gaggctgata ctggaaatat catccggttc gggagagtcg 2880

ataaagtcta ctccggcccc gtggatgaga tgctgcggaa acacagccgg tttaaccatc 2940

tctgcatggg cggagagaaa attgataagg ttggcgaagt gatccgcaaa tcctacggac 3000

acttcctgaa cgacgacagc cttctcacgg ccatctacat tcgccatgtc gatcgggagt 3060

tcgatacgga gtatcacagt gctgaagagt tgaatcttgt cgaccctcgc ccaaaagctg 3120

gggtaatcga catcagcgta gcgcgtcaga agccctctga gacgttttaa acgtaaactc 3180

atggttttac cggggcataa aatatggtgt cttagaaaga cactgagagc tttagggatt 3240

aatacatgag tgaattttat tcaagggcgg cggctgtggc agaccaagct ggcaatgaag 3300

acgaacgagc agggccggtt tttaatttgc agcccccgtt aatcatagtg acagtaaaat 3360

atctgtcaca aaaacagtac gagagagatt aggatctcag tagtggtcag aagaaaaata 3420

tgtactaggt taaaacaggt acatgtttac tggtacgcat cacataaata atagtaatgc 3480

actccaggta aataggcgat tgtccagtag acaaccgcct gtaatgagac tatttgcctg 3540

tttcttgctt gtttaagccc actgctttct gataatagct ggtatcataa tatttatgcg 3600

tatctgtcag atttttctct ggcttagcaa gcctgcttcg caacagtaga acatttttta 3660

ccccttctgc attaatagca gcatcccgtt gcagcccatt gttaagtaat tcctgtaatg 3720

caggtcctgc cagctccgcc gtcattcctg gtgccttttt gaccagaatt tcttctgctt 3780

ctttttggtt acgggggtca taaatccagt tcagtccgtc gatatagcta cggatgtaac 3840

ttaccagaat atcaccattc tgagccgccc aggagcgggt tgtaatgcca gttgtgccct 3900

gatagtcgcc aagttcactt ccggaggcaa ggatcttaaa cccattttct ttcgcctgca 3960

gatttaatgg agtacggaga agtgttgcat ctgtcttacc ggcgagaagt gcattaaagc 4020

gatcattcgt actgccaaca cttgtatagt ggacatcatt ttgtgtcagc ccgtttttct 4080

caagataatt ccggataaca aaggcatagc cagtggtcaa agcgtcgact gaaacttgtt 4140

ttcctttaag atcactgatg ttcttaattt gagggttagc aactaatgaa agaagcccgt 4200

tatccactcc ataaaacgcg aacatatccg gattcactac cggctctttc acctggccct 4260

cttgatacgc gatgacgtta tcaatacctg ctactgcaat attatacttg ccattcagca 4320

ggtttctgac cagttgaccg gaattgggtg tgtaatccat tttcacatta agaccatttt 4380

ttctgaaaaa gcctttttcc tgggcaaccc aaacaggcag gttccacccc ccctgaaaag 4440

taatgacgtt aatatccctg atagatgagc ttgattcccg ggtatccgcc gcgtgtaggg 4500

cgccgggcag gataaatgca agtgaaacgg ttaaagccaa gcatctgaac ataatattta 4560

cctcttactg tgaacagttc gtaagagttt aaaaaaatgg gtaatgataa taaagtagaa 4620

agcattctgg ctatctggcg aataactggc tcatttttac cagcaaatgg ataagcataa 4680

gcgccggtaa ggcagcctcg aatgcgcaga tctcggtcca ttgccagtga cgaaagccca 4740

gactgctgag agcggattct agagacatgc ctataaattc tgacgtgacg aagagttgct 4800

cgttacattt agaaatcatt accgccatga aaataggtat tcacttactt atgtattttg 4860

tcataatcat gtgcctgtag attttcttct gtgccgtgtt gtctgggttg ttcgcctctc 4920

aagcacgctt aatatctgta tcaaaataac cacaaaggaa aagacacatg acattgccat 4980

acggggtgat atcagatccc cattatcatc gttgggatgc ttttgcgaca acaaacgctg 5040

acgggctgaa ctctcgactg gagatccaac tggatgccac gaaagaagct gccaaagcca 5100

tgaaagctgc gggctgcaag cacatgctgg tggctggtga tactttccat gttcgtggtg 5160

ctatatcgcc ttccgtcctg catttcgtga ccgaaactta cgagtggatc atcaaagagt 5220

tgggcctcga agtggttatg ctggccggca accacgacct cgaaaccaac gattccgtat 5280

acagcgccaa tgcagcggcc tctctgcgct caatcggtgt ggaaatcgtc tgcggcaaac 5340

gtcctcactc catcaaaatt ggcgacgtta ccgtccatct gattagctgg cgcaataacc 5400

acgcagagct tatcagcgac ctcaaaacac tgcgttccgg gctggatggc gacaatcacg 5460

atgtcgttgt gcatacctcg atcaacaaag cgatccctac catgcctgat gtcggcatcg 5520

acgcacagga actgaaagat atcggcttcc gtttgttgtt gtccggacac taccacaacc 5580

acaaagaagt gctgcctggg gtggttagca tcggggcgct gacgcaccag aattggggtg 5640

atgttggctc gctggctggc ttcatgatcg tcaaccctga cggcacattc acccaccacg 5700

aaacctctgc acccaagttc gtgaaccttg aggacgatgt ggaagacgat caaattcgcg 5760

gtaactacgt gcgctttcgt gccgttgttg agaacgatga agaaggcatc aaactccaga 5820

acgtcctgaa aacaatgggc gcgaagggtg tcgtctgcaa cttcatccgc aaggcatcga 5880

tgatggaagg ctctgccagt actgcggaga ccagcaaaat agacagcctg ggcgagtccg 5940

tcgcggcgta ctgcaagatc gttcacgaca ctgatggcgg cttcgacctg agcaagctgg 6000

acatgctgtg tcaggaaatc ctgaccgaag cggagagtgc ggaggcagtg tgagtacgaa 6060

ccattctggg agctttcggg acttcgtctc cacaatgaga agacttgaac gaggccagac 6120

ggtgatgttc cacaagccct acccacctaa tggaaaccct gtggcgtttt acctgggaag 6180

attgagcaaa aagggcgtac taaaacgcaa atccttcccg gctcacacgg agtttcaact 6240

acgaaaaggc cagcatttga atcaaaaagt ttgaggcatt gtatgaaatt tctaaagctc 6300

caggttgaga acttcatggc gttagccagc gccgaagttg agttagacca acgcggtctg 6360

gtgctcattc agggtgttaa cagtggcgac tcttccgctg ccagcaatgg cgcgggcaaa 6420

tcgactttga tgaacagcct gatgtggtgt ctgtatggcg aaactgcgca tggcgtcaaa 6480

ggtgacgacg tgctgtctac aggtcacgaa aaaaactgtc gtgtgatggt aactgttgag 6540

gatgaaggaa agcgttacgc catcattcgc caccgcaaac acaaagagtt caagaaccgg 6600

ctgatcgtcc gtggcgaaga cggtgacatg accaaaggca aagacacact gacgcaggag 6660

ttcgttgaac gcctgattgg tgcatcgaaa gaggtgttca tggcgtccat ctacgccagt 6720

caggaagcaa tgccagatct gccgggtatg tccgacaaga acctcaaaac catcgttgaa 6780

gaagccgctg gcgtcgaccg gttaacgcga gcctatgcca ttgctcgcga gcgtgctaat 6840

gcagctgccg cacgcatgga tgttaccaaa tccaaaatgg acgcctgtct cacgcttatc 6900

gagaccgcgc agtcagagat tgaggcggcc aaagcgtcct ctgatagttg ggaacgcgat 6960

cgcggcgaac gtctggacaa ggcccgcgta gatttggctg gcgcggaggt aacgctgtct 7020

gaagtcgtga tggaaattcg ctcgctgccg gaacagatcc gggatacgga aaacgcgatt 7080

gctggcgaac gctgcaagct ggcctccaaa gaagagcatg acgccaaact gctgaaggtg 7140

cgcggtgcga ttacggagat ccgctcaagc atccgcactt cagaagcggc acagaacgag 7200

tcgatgaacc gtgctcgctc gtttaaaacc aaagcagaag aggtcagcac aaaggtcgga 7260

gcaccttgtg ttacttgcgg aaagccctac tgcgaagaag atttgtccac cgtgaaggag 7320

agtttcattg aacaagcgcg taatgagatc ggccaggcgc aagcatcagc ttcggcagtg 7380

gctcaacaca aagctcgtct tgagaaagcg ctcggcatcg aatctgcact ggtcgcagcc 7440

acacccgacg tttcagaaat catcgccaaa atcgaacgcc tgaccaatga gctaagtgcg 7500

ctgcgtcatc gcgaacgtga agttgtggcc gtcgaagcga tggtggcgcg ggcgcgtacc 7560

gatgtgaatc gcattatggc agaggtaaac ccatttctgg ccgttattaa gcgtcatgag 7620

gacaacctgg ctgccaataa atctaatcat gcagtactta aaaatgagtt aaagagtatt 7680

caagaacagg ctctgttgct ggagaaggct cgccaggttt actcccctgc aggtgttcgt 7740

tcacacatcc tgacctccgt tacgcctttc ctgaacatca ggactgcgga gtatctcaac 7800

acgctatcgg acggcaatat cgttgccgaa tggtcgacaa tggagacaac gaagaaaggc 7860

gagtatcgcg acaaattcaa tataagcgtg accaaaacag gttccagcaa atccttccag 7920

acgttgtctg gtggtgagaa gcgtaaggta cgtattgcgt gctctctagc cttgcaggat 7980

ctggttgcca gtcgcgccag taagaatatc gagctgttta tcggcgatga aattgacgac 8040

gcgctcgaca ctgccggtct ggagcgtctc atggggattc tggaagccaa agcgcgtgaa 8100

cgcggcacag tgatgatcat ctcccacaaa gagatgaaat cgtggttccg ggaaaccatc 8160

actgtcgaag tcaaagaggg tcgcagctat gtcgtttaac ttgagccgca cgcagttttt 8220

gcagatgttt gccgtgatgc aatctataaa gctgataaac caccatacgg caaaagcagc 8280

tgcgcctgca cttttgtgga aaaacgaaaa catcaatgac gaccagttct cggtattaac 8340

cagtctgttg tcatcgactc cgttgatgcc gagcttggct atgttgccgt caggaagcac 8400

tgcgccgatc cttgttaacc catttacgga aggtggatat ctcccacatt ctgggccggg 8460

gttcgttgcg atacctgaaa ccggaacgct gaatatccaa gaaaatgcgc tcttcaatgc 8520

aatggagacg cacatcagca ccgcattcac caatctgatt cgacacgcta acgcacgcgc 8580

tgatcacgtt gcaatgcctg gtgctgcttt cgccagcgtc tctgttgact atgatcggca 8640

cgcgccaatc tcaaagcggg cgaaactctg cttttacgag gagggatgtg aagtagcggt 8700

tattaaagtt cttctccccc atgtattcag cgcgaatgaa aaggttgcac accatctgat 8760

cgacatcatg cgacatttca tcggccagag catgattgat gcagacattg ctgcaggtgt 8820

tctaaccaac gatagcattc atgttgttag cgacattccg aagccgccaa ctcgcgagcc 8880

ggagaagaca cttgaacaga aactaatgga atgcccaacc tgggctacgt ggtaaggaga 8940

ccaaaaaatg agtaaaacca ttcgtgtggt tggcgtcgac ccttcaatga gcaactttgg 9000

cctggcgatt ggcacgctgg atctggaaac ggataagctg gacattcatg gcctgacatt 9060

ggtggaaacc aaagctggtg gcaacaagaa gacggttcgc gtaaacagcg acgatctacg 9120

ccgcgctaac gaaatctggc gcaccgccaa gcccataatc gagcaggctc atatggtgtt 9180

ttgcgagttg ccggttggta gccagtccag tcgcgcacaa acctcatacg gcatctgcat 9240

tggcgtactg gcgtgcgtgg ataagccact gatacaggtc acgccaaacg agattaagca 9300

ctatgtcggg aataagctga ccacgtcgaa ggaagagatc attcagtggg ctacgcagaa 9360

gcagccaaac gccccgtggt tgcgccgcaa gcaatctggt aaggaagtgc tggtgaataa 9420

aaacgagcac cttgcggacg ctgtcgcgtc gatttacacc ggaatgcaaa ctgatcaatt 9480

ccgtcaggtt cgcgatgtgc ttgcagggat tttataagtc gataattgat aggtaggtgc 9540

ttatctatta acataaggcc actatattta gtggcctttt ttgtgcccag aaaaccccca 9600

gctaggctgg gggttcagta aagctttcag ctttgggtca gttataaaaa ccccttttga 9660

tttgttaaaa cagtttgcgg tctggcaact gcaaatgttc aacaagaaat caaaaggggg 9720

tcccaatgag ggatgaaaag agcttagcgc acacccgatg gaactgtaaa tatcatatag 9780

tttttgcgcc gaagtaccga aggcaggtgt tctacaggga aaaacgcaga gcgattggca 9840

gtattttaag aaaactgtgc gaatggaaaa acgtgaatat cctggaagca gaatactgtg 9900

tggatcacat ccatatgctt ctggagatcc cgcccaagat gagtgtctcg ggatttatgg 9960

ggtacctgaa gggaaagagc agtctgatgc tttatgagca gtttggcgat ttgaagttca 10020

aataccgtaa cagggagttt tggtgtcgag ggtattacgt tgatacggta gggaaaaaca 10080

cggccaggat acaagaatac ataaagcacc aattggaaga ggataaaatg ggtgagcaac 10140

tctcgatccc gtatcccggt agcccgttta cgggccgtaa gtaatccata gatgcaaatg 10200

tcagatcgcg atgcgcctgt tagggcgcgg ctggtaacag agccttatag gcgcatatga 10260

aaaacctccg gctatgccgg aggatattta ttatacccga taacaaaatg ttttttgcct 10320

tatccacatt gcgataatta caccaacaag aaaacaagat gtttacgcat ggaggatatg 10380

cacatgaccg atttcactat ctcccctaaa gctgaaaacg tatggctgga atcctggctc 10440

gacctgtcat cggaagagaa gcgagaaatg gatcatattg aacaggacga acagtgtgat 10500

gcccgcttct tccactttga gggcagcgtt tatgacattg ccgacttcat gcgcgatgac 10560

cgattcccgg gctggcacgc aggctaccca ttaaatgcct tcgccatgct gatgatccgc 10620

gtggatggct caggcgatac catcgacgtc ggtttgctcc actaagagaa cgaggccacc 10680

catgctggtg gccttaaatg gccatcctgt ttcccgcagg ctaaaaacac ccacctctta 10740

ccgccaggct accgaacaac cctccgactc cctgcaggcc accatctgcc ggaacagaac 10800

gcttggacgc cttatgcgcg tagcgataat taaaccaaca agaaaacaaa ttgtttaaag 10860

gattatcacc atgaatttta tcgctactgt taacacccct tcgcatggcc atatttctgt 10920

gacgttctct gataacgata aaagcgtgct gggcgcctgg cgtgacaatg taaccatcga 10980

gctgtccggt aaagagaaac agcagatcac caatgacatt atctgcaacc gtcgccataa 11040

gcgcgtattt gaaaaagcgt atgtctccac ctcgggattt ggtgtattca tcttcccggt 11100

acgcagcggt cgcttctgcc ggtcaaaact catcgagttc gccacgcaga tcgcgctatg 11160

ggttaaaaca gaatccggat tcgactttac cgaacaggaa gcagtggggg aggggatgcg 11220

catcgccaac aacgccatca agtgcaaaaa cgtcatctat gaagcaggaa tcgactcgtg 11280

gagtatctcg tgcggggact acgtgaaaga ggtgtacgga aagaaccgca ttcacatcct 11340

ggctggcaag taagagggga ggggctggaa acgccccttt cttttcgtcc accagttgcc 11400

gcagggaaac ttcagaaacg gccagagagc tgtccgggga accgaaggga aacggccagg 11460

gaattttcgg gaaacggcgg ggtttgcctt tatgtagaaa acagagcggg agaagccaaa 11520

aatcgctcca gaaattgcgt agcggcgctg gggtagttgc cggtggagtt tcagctcctg 11580

agccacccag atagctttcg ccatgtgatt atgtgaatcc gtgggaaagc cactgcaagc 11640

gcgtacacgt cgcgtcaacg tgccaatgat acgcgagcgc ccacggatca tgccaatatt 11700

gccgacacgt cccgaaggat agcgcggatc acgtcgccag atatcgccag acgatcacgc 11760

ccacgacacg acaaaataag ccacgcgcta aaacgcgcta taacgtgttt tttattgtgg 11820

gtaatgagta tgtaccacca cacataaaaa cgcgttaaat tggcgcgttt atggcgctta 11880

tttttggtct gttttggctg acttcagaca ataaaaaacg cgccaacaat ggcgcgttat 11940

ggtgtgcgga tcttgaaacg aaaaaagcgc ccatagtggg cgctattgtt tttatttttc 12000

taagtgaatt ttaaagccag cgtttaaaaa ttcttgaatc attaaaagaa catcggattc 12060

tttgattcct gcgcgcttcc tatgctccgc gctattcaga tctattttaa acgtggtttc 12120

gtcgactact tcagagctga gagcgtatcc agctaaacca gcgatatcat aaacaagagt 12180

atgattatgg atgttaacgc cagcgataaa aataaccata aaaacgctcc ttaaaaaata 12240

aaattgaata cagacttaag atcttttgaa taagcgccca tagtgggcgc tatattcaat 12300

taattacgct ttgaaagcgt cagccagata gttataaaaa tcatttttga taaagcgata 12360

ttgctgcgat ccgtttttag cagcgcccat tcctttgatc ttctcgacca gtccgagacg 12420

ttcacaaaga ttgattagtt ggttggcttg agtgtagcca gcgtccaatt taatttcgtt 12480

ggcttttttc gcttcattca tcaaatcgaa aacagcgcca ttagtgaatg tttccaattc 12540

atcattaatc atttcgatta atgcgaatac gcgagatccg gacatatcag cgacggaata 12600

aacgcattta ccagacttga tagatttaac cagataaacc agtttttcga gtgaatagct 12660

attggtcata gcttcacgga aaaacgcttc aggtgcttgt ttgcttgctt taatcgcgta 12720

gtaaaagaca ccagctaatt tctcatcatt aacagcgttt aaaacgttgt tggtaaagta 12780

tgcaagtttg gtagtcgctg caagcatgtt agctttatct gctttggtgt gcgtaccatt 12840

ctgataatga ttgttataag tctgagtcgc attgttggct gcaacttgca attcattagc 12900

gataactaca gcagcgtcga tgatagattt tttagagata gcaacgttag acatgatatt 12960

aatccttatg taatattgat aacttaattt gttatttatt tatcgttagc gtgttcgctt 13020

tcgatgtgac taattatcga tatacaaaaa ttaaaatcaa gagttttttg cgcgggaatg 13080

aaaaaaaatt ttcttcaata aaaatcaaag tcttagaaat aaaacgcgtt ttctcgaagg 13140

tgttgcctaa ataaattccc tattcggtca atcaccctta tatatttaaa acggaaccgg 13200

gattagggga ggtaaatata acgggaagtg acacataaaa taataaccgg acttagccgg 13260

ttattaccct tatagattta aaacggtaaa atccgttcga cccaatcgaa catgacgact 13320

gtcttccgac cgtcccccat gttgagcgtg gcctggcaag cgtctacgcc tgaagacccc 13380

ccctcaattt cacggccatc cgccatgtag acccttatag acttctgcat ctcatgagcc 13440

tggcgacaaa ttttaaagaa atcacggcga gatggccgat tgtccacata gtctgggtgt 13500

accgttgtcc gacccgtgaa atcgtgcgca atgccttctg tcacacctga ttcaatcgtg 13560

ctgattcgct caagtgggag ccttatacga ttttctttgt cgaacggggc agggcaaagg 13620

tcgactttgt tgcgcgacga catgagaccc tgaacgtaca tgcagaacac ctgaccatct 13680

tccatcgtga cccttacagg aatgagagac ttacgccaga acatcagcgc tttctccacg 13740

ttggagtaat cgcgcggcca gacttctgca ggaatcccgt aggtgatgtc agttttattc 13800

gtcatatcgt cacagtgtcg ttggtaggat atcgatgtca cctgcgttgc tggtgaatac 13860

ccggaagact ttcgtctcgc cagctttggt gatggtctcg cgttcctgac gagcagggtt 13920

cagtgcgcac agcccggcgc cctcaagtga ggcgccaaca atccactgcc cggcatcaag 13980

atggaacgtc gctttttcgc cggtctccag tttcgcaact gtctctccat taatgaagat 14040

ggatgcgtcg cagcccgcac ctatcatacc tttgtccctc ataaccacca gcgtggttgg 14100

ggcagacgtc tggtatttga aaactcttgc ctgcggagcc ggttttgcat tggctacaga 14160

cactgggcgg gatgaacatg cactcaggag taaaacgggg atggtaatca gtggaagtag 14220

aacgtgtttc atggcttgaa ctaaatcctt atcacttcaa cgaacaaggc gtcttgcgac 14280

gcccttaatg cttaatcgag acgtttgaga atatcggcca gatcttcttt ggtcatgcca 14340

gaggattcgt aaatcttcat gaccttttca cgagcctttg cagaagcctc taatgacgta 14400

gccgccttat caaaatcggc catcgtcatg ttggacagta ccagattgat gacgtctgct 14460

tttgacagct ttatgttgcg ctcacgcagt cgattctgaa aggtttccag cttgtcgtta 14520

gctttttcgg ttaactgaac ctggcagtgt atagcgcgtt tctcgctcat gcttactctc 14580

tattcaaaac agtaaaatcg aatgtgctac ccaccggcaa gactccttcg gcaaaccctg 14640

gcgtcgtgtc gataatgtgc ttccgctcat atgaatgcga catgaggtat ttattgctca 14700

cgtcgatgaa gtcggtaata aagcacacgt tagcctgatt ctttttggct cgaagaccgc 14760

gaccaactcg ttggcgcatc tcaacttcgg ctttgccacc gccacccaga atcaccgcac 14820

ctacgcttgg aacgtcgacg ccaacatcca gaatggttga accaatcaaa acatctatcc 14880

tgcctgccgc cagactgctg agctttgctt gtcgggtagt ctggtttgat tctccgtaga 14940

tgaaatcgac cttcaggccg ctttccttca tcatttccat cagaatctga ccatgacgct 15000

tcaaacgaac cagcgtcata cagtttagac cgtgactttt gtacattaac gcttcgcgca 15060

caatggcctc gttgcggccc agattgtaaa cgatgcctaa ctgataggct ttctggtaag 15120

ccgtactcat cccaacccga aagttaaggt gtttcgaagc aagttcggcc ctgattcgca 15180

cctcgtctgg agtgtacgcg attttatgat atagaaagta gggttttgct aaaatacctc 15240

ggtcgatcaa atatttttcc gtcaccttta tctcaatgcg acctgcaacg gccatgagac 15300

gcatatttgc ttcggttgag tccttcatga acggcgtagc agtcagcgcc agacggtagt 15360

cggcattaat gcacaaccgg gcgatatcgt agaagtttga accagatgat tcgtgtgcct 15420

cttccagaat cagcagagaa acgctggaca ggaagcgctt aaccagttcc cggcgcttca 15480

ggtggtaccg ttttttctct ggtgaggcat cgcgcggcgg ctcttcgaga aaactggcca 15540

gggtctgcac cgtggcaacg ttgatatggc gcgagacctg gaactcacca gatccaatca 15600

ccccaacttt ctgacctttc agccacggct cgccattctc cgcgcggtag tcgattgatt 15660

tctggaagtt ctctgccatc tggaacatca gaaccgagcg cgtggttaaa aacagcgtca 15720

tacgaccaat gcgagcagct gccttacacg ctacgttcga tttaccgcca cccgtcgcaa 15780

tctgggcaat catcatccct tcgcgcacca gtgtttccac agtctgatcc tgatacgcat 15840

agtccgggtt atacgggaat gggttaacta ccgggttcgg cttgcccagc gcgggggctt 15900

tttccttgcg cacatgcacg catttgatgc cagctttcag aaggttggcc gctactggct 15960

tcgcaaaccc agccgggaac gcgtttttgc tccagttgaa catcgtgctg gtccctttcc 16020

agtcaccagc ctccacttca tagctcaaca tctcctgaac gagccgcttc acgttgtcat 16080

cagcgccaga aatcagcgca ttgactgcat tcgatacaat ccgaactgtc ataaacctct 16140

ttccttcgtg ccttttgtat ggtaattggc tattatagta agtaagtact tatataatgg 16200

attgtatcag aattatggat gtgaaaatta cgattctgca ggtggaagtc gcgaacctgc 16260

gtccgaatcc ctggaatacc aactccgttg gggcgcaaaa cttcgaaaaa ctgaaaggct 16320

ctatcgaaaa attgggcttt tttaagccaa ttctggcgcg ggagctggac gggggcattt 16380

ttgagatcct cggtggcgaa caccgctggc gtgccgcgat ggagcagggc atttcaacgg 16440

ttcccgtcat ctccgtgggc aaaattaacg acctggtggc caaacagatg tccctcgtcg 16500

ataacgagcg ctacggcgaa gacgatcagg ttgctttgca gcgcttaatc gaagaaatcc 16560

agtctgaaat cgactaccgg ttgtccgata tcgccccgta tgacgacgaa atggcggcaa 16620

cactcgccaa agcgtccgtt atcgatcttg aagcgctgga agcgctctcc cgtggagatg 16680

acgagccgat cgaagaggac aaacgcgaga aaaccgagcg agtcggtgct gaacaccaga 16740

cgatgcgctt caaggtgaca tttgatgcat cagatcgcgt cgccgacacc atcaaaacca 16800

tcatcaaaga gcagggaatc aataccggta acgaaatgga gaacgccggg gaagccctgg 16860

tgtggctggt cgactactac aaggagcgta tgtaatgacc aaaaactttg aaatcgtcta 16920

tcgaaacccg gcagaactca tcccgtatga gatgaacgcc aaaaaacatg acgaacagca 16980

gatccgcgac ctggctgccg ccatcaaaaa gcgcggtttt gaccagccga tcacggtcga 17040

caagcacgac gtcatcatta ctggccacgg tcgtcgcgag gcggcacttc tggctggtct 17100

ggagcgtgtg ccggtcatcg ttcgcgacga cctgagcgaa gaagaagtga aggcaaaacg 17160

cctggaagac aaccgcctgg ccagtattga ctacgacgcc atcaaattgc agcaggaact 17220

tgaatccctg gtgctgggcg acgttgaggt cttcggtttt gaagagcgcg agctgaacgt 17280

gcttgtcggc agcatgaccg aagagatgga aaccggcgct ctggtgctcg atctgggcga 17340

agagacggaa cgccagaaag aagagcacac cgagatcagt cgcgaagtgg ccgctgaaga 17400

agtccgcgtc atcgacgtat tgggctttaa aacgctccct gctggctctg ccattgtggt 17460

tggggatttg cttgcccaca tggaggaaat cacgggagag tgcggggtag acgctttcgt 17520

ggcgtatgcg gagaaagttt cttctgggga gctggctgca tgagcaaata caccatcaac 17580

gtatcgtttc agacccgcgt gaataaaacc atgcgcacgc tggagattgc cgaatcgttc 17640

ggtcttggcc tggacgaaaa agagtggacg ctttacgaca atctggagct ggaagtgaag 17700

cagggcgatg tggtgtacat caccggtcag tccggttccg gcaaatccgt tgtgctgcgc 17760

gagctgcaac gccagatgaa ggatgaaggg ctttctgtag cctccatcga tgactttacc 17820

ttcaacaatg aggttaacgt catcgaccag ttgggcaaaa ccaccagcga tgcgctgggg 17880

ctgctgtcta tggccggatt gaatgacgct tatctctttg tgcgcaaacc atccgaaatg 17940

tccgacggcc agaaataccg cctcaagatc gccaagctga ttgagtccgg cgccaaagtc 18000

tgggccgccg acgaatttgg tgctgttctc gaccgtgtaa cagctcaggt tgtggcgtcg 18060

aacctccagc gtgccgcccg caaggttggt gcgacggtaa tggtggcgac gacccacgaa 18120

gacctgaaga acgcgctgcg cccggatatg cagatcacca agcactacaa agaacgcgtg 18180

aaggtggaat atgcctgatt tgaagatcgt tgagctgaag ccatcgaaag aggctgacaa 18240

caacaacgtt gaagtcatcc gcctgctgga agaagcactc cagcacgcca gagaaggtaa 18300

aagccagagt ctggcgttgc tgatgatcaa caacgacggc agtgttctgg attgctggca 18360

taacggtggg cgtccatacg tcatggttgg ggcgatggaa tcgcttcgcc tggacttcat 18420

caatgccaat atcgagcgca ggtgatcgac atgacagaca tcatcatcaa acgctaccgc 18480

ccggaagagt tcccgcgtca tctggacttt ctggagcgta tgaccgttac caaaggcacg 18540

gttgaagact ggcacgcgct gaagtcgctg cactataaga cggatggtaa gccgttcgcg 18600

ccaacgtatt atcgctgcga actggacgac cggctggtgg gcgtcgtggt tatggcttac 18660

ccgaaactgc tgctggcgcc tcgccatcgc atgtttccta agctgaagcc aaccaccaat 18720

accaccgtgg ccaaccagta ttgggggcgg tacgtgaaca acaactttgc ggtgattagc 18780

cgttccgttg tggacactca gtaccgcggc gtcggcgtct cctatcgaat gattaacctg 18840

gttagcagga tgcacgaccg gccaatcatc gagatccagt cgtcgatgag caaatacaac 18900

ccgtttgcca tgaaagcagg gttccagttc atccgtccgg agcgtccgaa gagctatgag 18960

agtgcgttgc gcgtcttcca gcgtcatttc cgttccgacc ctggcgacaa cgaagcgatc 19020

gtcaaagagc tgttcgccat gagtgagtct cgccgtcgtc gtgcgctgcg tgatctggtc 19080

gctgactacc acaagaacag ttccctggcc aaagccgggc gtaatcgtgg cacgacgatt 19140

caggacattg ccgacagcct ggtggacgag gccagcattg tgaagctgct caaggatatt 19200

cacaacctga gcttcacgtc tccgctgtat ggcgtgtacc gaaacccgga ctttggccgt 19260

cagttgcctg acacgctgcc actgctggca ttcgacaaac agcctttgaa caaacctctt 19320

gaaattgcat taccggcata aggatttgcc atgacgttga ccgacaaaca aaaagacatc 19380

atcaaaacca tcaatttagg ccatgagcgt gggcatctgc tcgatctgga cgagctgctt 19440

gaagtgctgc cgtacaaaac gaccaaacag agtatgcagt tctctatccg cgcactggtg 19500

aaaaaggggc tggtggagaa aggaatgtgc cgccagcgcg gtgattctgg ctaccaccgt 19560

cgcacgctgg ggctgaccac gttaggtcgt gccagagcca aattactggt gatgtaagtc 19620

ggtctgggag ccagtttgag agcctgcttc cgtatatata aatactaagt gacttattaa 19680

atatatacgg aagcaggttc tgaatactcc ccagcccggt tttaaacacc cagaaaacaa 19740

attggttagg catagaatta aacaagttgt ttaggagcgc aaggatgcgc tctgagtgtt 19800

ttagagggat ctatgactgt agaaaaagac gagagcaaaa ctcgcctgac gccagctgag 19860

tgggcagaag ccgaagcgaa gtggacttcc ggtgaataca cactctccaa gctggaggaa 19920

gagtacggca ttcgtcgtga aacgctctcc agacatttca aaaagcgtgg attagagaaa 19980

ggcgcggact ccgtggggaa gatggtgcgc gagtcgctca aatccgacgc agagctgcgt 20040

gcgaaggcgc gtgcagagaa aatcgaagag cgccggactc gttacgacga ttgggcgttc 20100

gcactcggtc ggatggtgat gcatgaggtg gccacagcca agaaggacgg caagccactc 20160

gcaaccatcg aagatgacct gaagagtctc cagcgtgcca gcggcacact cgctaagtgc 20220

ttcgaagtat cgtcgaaagc gctcggtatg gatcgcgccg aaaacgagga cgacgaaatc 20280

ccgaatctgg tatttggcga acttacgcct tcccaggtgg cgcagctgcg taaggaagat 20340

gatgagccgg atctgattga tgacgatctg cttgagtcac tcgaagagga agcactgagc 20400

gaagctgagg gcgattctga cgcgtctggt gatgaaagtg atgggagcgt ctaactatgg 20460

ccatcccgtc gtctctgagt ctcgtacagc tgcattctgg gcagatgcaa gtcttccagt 20520

cgccacatcg tttcaaagta gtgtgtgcgg gtcgacgctg gggtaaatcc cggttgtcga 20580

tttccaccat cattcgcgcg gcagccaaag agaagaagca acgtgtctgg tacgtcgcac 20640

cgacgtacca gatggctcgc cagatcttgt gggatgacct gcaggaagtt ctgccgcgta 20700

aatgggttcg taagaaaaac gacaccacga tgaccatcgt gctgaagaac ggctctgaaa 20760

tcgcgctgaa aggtgcggat aagcccgata cgcttcgtgg tgtggcactg cactttgtgg 20820

tgctcgatga atttcaggat atgaagccgg atacctggta caaggtactt cgtccgacac 20880

tgtcctcaac ccgtggcggt gcgctgatca tcggtacgcc aaaaggcttc tccgagttcc 20940

acaagctgtg gactatcggt cagaacaaag atttgcaacg caaagggcag tggaagagct 21000

ggcagttcgt tacggccgat tctccgttcg taccgagcgc ggaaatcgaa gcggcgaaga 21060

acgatatgga ccctaaatcg ttcgcacagg aatacctggc cagcttcgaa aacatgtccg 21120

gacgcgttta ctacccgttc gaccgcaatg tgcatgtgaa gccactccag ttcaatccga 21180

aactgccgat ctgggttggt caggacttca acatcgaccc tatgtcatcg gtcatcctgc 21240

agccgcagcc aaatggtgag ttgtgggccg tggacgaggt tgtgctgttc tcttccaaca 21300

cggctgaagt gtgtgatgag ctggagcgcc gtttctggcg ctggaagtct caggtcacta 21360

tcttccctga cccggctggt gcgtatcgcc agcacgcacg cggcgaatct gacgtcgata 21420

tattcaagga aaaaggtttc ctccgagtcg attatccgaa gaagcacccg cctatcgcag 21480

accgtgtgaa cgccgtgaac cggatgttga tgagtgcctc gggcgaaacc cggttgtaca 21540

tcgatccgaa gtgcaaacat ctcatcgact cgctggagaa ggtgatctac aagccaggct 21600

cacgcgatat ggataagact ggcggcatcg aacacagtgc ggatgcgttg ggttatccgg 21660

ttcatcgtag gtatccggtg aaaaatcgtg ttattcttgg tggatctaga taagtaagtg 21720

cctacctaaa tatggaaaag aaacaaatgg aattgactga taagcaaatc aaggaccttg 21780

tggcacgacg ccacccggaa tatgagaaga aaaaagaaca ttgggatttc ctcgccagca 21840

cctacgctgg cgggcgtgcc tggttcaacg acaatatctt tcgttacttc aaagagggcg 21900

atcaggagtt caaagagcgt ctggaacgtg cctatcgctt caaccacact cgtgaagtgg 21960

taaacctcat caacaaatac ctcttcaaag aggtcattca tcgcaacacg gatgaagcac 22020

cggagcagat ccgcaatttc tggaagcgag ccacgcgcca gaacgcctcc atcgatgcgt 22080

ttatggcggc tatcgatctg caatcatcca tctatggtcg catctgggtt gttgtggaca 22140

gcaccatgaa cgtcgatgtt gagtctgttg cagacgagaa gaaaaatgat gcgcgcgcct 22200

acgcttactg gatttcgccg cagcagctgc ttgatgttgc ctgggacgaa gacggcaata 22260

tgttgtgggc gctgattgtt gaaatcgcgc gcgacgacga agatccgttc acgtcaaccg 22320

ggcaggaata ccagcgttac cgtctgtgga cgcaaaacga gtggtatctg ttccgtgaag 22380

aagtgaagaa aggttccgga aatagcggtc gtcgtcaggc caaagtcgtt ctggaggata 22440

gcggcgagca taatctgggc gtggtgccgg tgttcccggt ggattgcatt ggtgaaagcg 22500

agtctccgta tttcagcccg tcgttgattg atgatatcgc ctatcttgac cgcgccgtgg 22560

ccaactacct gtcgaacctt gatgcgatta ttcaggatca gacattcagc cagttggcga 22620

tcccggttca gtcattgctg ccgggcgatg aaaaccacac caaagtgctc gaaatgggga 22680

caaaacgcgt cttcaccttc gactctgaga gcggtaatca gccattctat ctgtctccag 22740

acccgaaaca ggcccagatg atcatcacca cgattaagac ggtgattaac gagatctacc 22800

actccgttgg tgtggcaggt gagcgaacca agcaggataa cgcacagggc atcgataact 22860

cttcgggcgc agcgaagatg tacgacttcc agcgcgttaa cagtctgctg gtgacaaaag 22920

cagaacgcct cgaaagggca gagcgccaga tgatgcaact ggcagcgaaa tggatgggtg 22980

tcgaactgga tgaagaccac tctctgatcg cgtacccgga aagttttgac attcgcggtc 23040

tgactgacga gtttgccgtt gctgagaaac tgtcgctgct ccaggcgcct gattctgttc 23100

gtcgtcatca gatggaaatg ctcatcgaga aggtcttccc gaacatttct gaggcgatgc 23160

aaaaggaatt tcaaaaagat ctcttgaaat ttcctccaaa aaatgatctt aacacccttg 23220

aaaataagtc agtacttact tatgatcgag atatatccca agaaagcggg caagatcaac 23280

cccgagggaa tggggactca tctactcaag agaccgagtg ataagtaacg aaaaggaatt 23340

tctatgaatc tgtggcaaat gcttatggcc cgtcgtggcc tgatggatgc agctgaagcg 23400

catgagcgcg gaggcgctgg tggcggtgct cctgctggag acaacgagca gggcaatcaa 23460

gacccaggta aacagggcga gcaaaaagag caaccgaagg gtgacgacga cgagtatgcc 23520

ggtatgactc aggaagagtt gctggcagaa ctgcgtaagt ccaagaaagc tggtgctgac 23580

ctgctgaaag agaacatgaa gcgcaaggag aaagagcgca cattggccga tcagctggct 23640

cagtacggtg atattgaccc ggcgcgtgct cgccagcttc tcgaagctga acaagccgca 23700

gaaaccgcac gccgggaggc ggagcaggct gaactggaac gccgtggtga gttcgatgct 23760

gtgaaaaagc agatgatcga agcgcaccca ccaggctgaa ctggcacagc gcgacgaacg 23820

ctactccgct ctggagagcg agaacgccga actgaaggct caactggtcg aaatgactgt 23880

tggcgcttcc ttcagcggct ctgccttcct gcgtgacaaa gttctgatga ctccggctaa 23940

ggctcgcgtt atctacggct ctcatttcga agtgggtgaa gacggtagtg ttgtgggctt 24000

tgataagcca gccggtcaga aagagcgtgc agttctggtt gacggtgaag gcaaaccgtt 24060

accgttcgaa tccgcgattg aacgcattct gcgtgcagat ccggaagctg acgcactgtt 24120

gcgcagcgaa gccaagcagg gtgctggttc caatagcaaa ccgacccaca aagtaaacca 24180

gccgaagagc aagtcgacta tggataagtt gacctccggt ctggggaaaa tcggactcaa 24240

gtaacatctt aaatcatagg gaaatgaaag atgccattac tgcgtgatga agctgaaaag 24300

ctatctaaca acgaacttga gcagggtgtg atcgagacca tcatcgatcg cgatgacctg 24360

ttcgctgttc tgcctttcat gaagattaac tctaaggcat acctctacaa ccgcgaagct 24420

accctgagcg aagcaacctt cattgatgtg aacgacacca tcaccgaagg cgctgcaacc 24480

ttcaccgaac acgttgcgaa gctgcgtatc ctggcaggcg acgtagacgt cgacaaattc 24540

ctggcgacca ctatgtccga caccaacaac cagctggcaa tccaggttcg tcagaaggtg 24600

aaaggtctgg cccgcgcatt ccgccgcaac ctgattctgg gcgactccac caccaacacc 24660

aaagctttcg acggtattcc gaagctgatg cacgacgatc agaagatcga catcgaaggc 24720

gcttccatga ccttctccat gttcgacgag ctggtcgacg cggtgaaaga tctgggcgca 24780

gactgcatca tgatgcgttc cgagcacctg cgtgcttatc gcgctctgct gcgtaccgtt 24840

agcctcggcc cgtcagaaat catgatggaa aacttcggcc gcccgatgct gtgccacaac 24900

ggtgtaccgt tcatcgtgaa cgacttcatc ccgactgatg ctggcaaagc aagcatctac 24960

tgcctgcacc tgtccgaaga gaacggtgtg accggtctgt atggcggcga aaacgccggt 25020

atcgttgttg agaacatcgg tactgttcag aacaaagacg caacccgtac ccgcgttaag 25080

tggtactgct ctctggcgaa caagcacgat aaggctatcg ccgcgctgac caacgtaaaa 25140

atttgatcag tatcgtaggt aagtaattat ctaccattta agggtgggct atacgcccac 25200

cctttttgta ggagcgagaa atgccagaac aaaagatgaa gatcacggaa gaggcgtttt 25260

cggatttcac ggggcatatg tgccgtgccg gattcaccaa ttccatctcc aacgagcctc 25320

tgagcgagcg ccagcagaat catcttgcgg cttgcttccg ggcaattccg ttcactcagt 25380

ctgtcaccat tacaccgact gcgccgtccg tattggtggg caaaaccgtt caacttagtg 25440

caggtatcac catgagcaaa agtgcagatt cattcacctg gacgtcagac aatgaccggg 25500

tcgccacagt cagcggtacg ggtctggtta ctggcgtgac tccgggcaaa gtgaagatca 25560

ccgccaccga taagcagact cagctttctg cctcagtcga agtgatcgtt aagcctgtca 25620

gcgtggagtc cgtaaccgta acgcctgact ctacctccgt tgagaagggg aaatcggtca 25680

agttgcgtgt tgatgtacaa ccgtcaaatg caaccaataa aaaagtcacc tggacttcca 25740

aaaatagcga caaagcgact gttgaccaga acggtaacgt agctggcgta gccgttggta 25800

cggcaactat tgaagtggtt tcgcaggatg gcagccacaa agctactgcg actgtggaag 25860

tgactgcagc accggctgcg taaccaatac atgggcggca tagccgccca ttaagtgaga 25920

agaagaatga aaccagcaaa aattcgttta ttggagcctc aatttttggg gtacacgggc 25980

attctctgcg gtatccagtt tgtcgacggc atctcggttg ccgaactgcg attcatcgat 26040

cagcagcgga tttgtgcctc catgcgtgcc actaccgttg aaggcaaaaa tgtatctcct 26100

tctgccgcgt acagcagccg caatgatttg actgcggacg acattgtcga gacggcggcc 26160

ccggatattg tgccaatgaa acgtggtaca gctgaagtgg aagccaaacc ggtacagcgc 26220

tttactcgtg aagaactgga gtcgattgcg gactgtgaag gtattgcggg tctgcgtcag 26280

atcggcaacc agattggcgt gaaagccaaa ggcatcgttg aaatgatcga aggcatcctg 26340

aaagcacagg gcggtgagta atggcgcaga tcgacacgta ccgtagcggg gaagctgttt 26400

ccctgtcgtt tgcatttaac gttctggata ttgagtcggc cacgtatacc gtcagagatg 26460

gcgctggcgc gatcatcgtc gataacgaac ctctcgatat tactgagggg cagatgtcca 26520

ttccggttgt cgtgtcggcc gaacacaacc tgctttcaga taaagagcgc gatctgcgac 26580

acgtcattgt caaagcggtg gcatccgggc tgacgcatga agagcgcaag atgtacgttt 26640

tgctgaatag cttcgagctg tcaattccag gccagtcatt cgcaacggtc gcagacgccc 26700

agatgcaagc tatcgatatg ctgaacggcg acaccctgtt agctgatggc gaagggctga 26760

tgcgcaaacg tctcattgag gccaccagac gcgtcaaaac gctgccgttc tcaatccgca 26820

aagtcctgcg tatcgacttc gaccggtacg atcgcccgca aaacatgctg aacgtctatg 26880

acattccgtg gggcgctgac ggggcatatc gtcacgatct gatcgattgg gagcagatga 26940

cgccggagaa attcgacgag ttcccggact acttcaaaca ggcattaatg ctggccgtgg 27000

ttaatgaagc ctgcgaaatc gctaacggta atgacgtagc ggcagcccgc gaggacggca 27060

ttctgtctga gtccattggc gaaacgacca atatgtaccg taccggcaaa gcggcaaacg 27120

tgcaggtggc tcgcagtacc tggcgactgc tggtcagtta catcaataac cgcatgattg 27180

ttcgccgtgc gtaacgccag tcgcattatt tacttctggt cgaaaggctc aagacgagca 27240

atcgcgcctt cgcctggtaa tgagtgcggc tgccaaccac agggagagtg catgaacatt 27300

tcatggcaag cagagatagc gatttaccgt ctgggttcga agaacgtcta cggtgaagcg 27360

caattgcagt tcgtcagaaa gacgaacgtc ggcgtcgtta agtttgagca aagtaacgag 27420

aagtcatcgg tacgtgctga cagctccggc agtcgcggta aagcgaatct ggaattgttc 27480

gatgctgttc tggtgatccc acttgaggcc gcagtacagc ttgatgacgt tctcattctg 27540

gaggggcaaa agctgaaggt atccagcgtg catcgtcgct ggggactgcg tgggcgccct 27600

gggcatctgg aagtaggggc aaacatatgg gtctgaagta cgacgcgcat cattttaagc 27660

gtgctggcga caggctcaat aacagccaga aagcctttaa gcgttatctc atccgtgaca 27720

tggagaagct ggcgcgtctg gttgagcgtc tggcgcgggc aatggccccg ctggagactg 27780

gctcactcga aagcgcgatc ttcgcgagag ttgtcaaaga aggctatacc gggctgcgta 27840

ttgagttatc ggtatctgga gccaaaccac gcgaaggtca tccgggcgtt gaggttggcg 27900

attatgcgga gtacatggag ttgggcaagt atcgtctcgg ctatctatcc cgcatgaaga 27960

gcgtcaccaa cccgccagtt gctggagtga agccacgagt tgggcctttg ttccttgaga 28020

gagccgtgca gatcagtgag aaacagttca ctcagacgat agcagaagcg gcaaggaaag 28080

caggttttac gagaggttga tgtgtttatt gaagcatttg cgagcctgat gcagaaggcg 28140

aagatcggta cagtcggcac tgacattttc tgtcactaca tgccagccaa tgtgaagtcc 28200

ggtgttctgt tggttactcc caatacgggg atcaccattg accatgagtt aaaaggcttc 28260

tatcacgact ctttcaccgt catcgtgcgt aatgcgacga ttacaaagac ggtggcgaaa 28320

gccaataaga tcatggacat gttcccggtc gaagaaaccg tgtcagatgg cgtttacttc 28380

cggttggttc gaccaatgtc gatgccgatt acttatccca aaaatgaagg ttcgttgatt 28440

gaagcgggta tcccgattga atttgcgggc tatttgttga attaataaaa taggtaagta 28500

tatacttatc attaacacca tgaaggtgct gatttaacgg aaaaaggagt tttccaaaaa 28560

tgtccaatac ccatgtaaaa aacatcaaac ttggcgcctg caaagtgtcg tttggtggcg 28620

ttgatctggg ttacaccaaa ggcggtgttc aggttgaagt tgcgaccgaa actctgaaag 28680

tcaccgtaga ccagctgggg cagaccacca tctccgagct ggtacagggt cgtaacatca 28740

ctatcactgc gccgctggcc gagtctgtgt tgcagaatat ggtcgatctg atgccgggtt 28800

ctaccctgag cgaagaagag aactctgtga ccatcacttc cgcacagggc gtcaacctga 28860

tcgacgtagc caaagagctg gttctgaccc cgcaagatac caccgactat gtcctgacca 28920

tcccgaaagc tgcaaccgca ggtaacttca ccatgaccta ccagtctgat gatgttcgcg 28980

tgttctccgt tcagttcacc gcttacccgg atgacgacgg cgtgctgggg aaaatgagcg 29040

gcccaaagcc ggttaaaacc gtctctatct ctccggaatc tccggaagtt aaagccggtg 29100

agaccgtgca actgactgcc cagatcaccc ctgcagatgc cggcgacaaa accggtgtgt 29160

gggaatccga caatcaggag aaagcaaccg ttgaccagac tggtctggtt cgcggagtag 29220

ctgaaggttc ggcaaatatc tcctttacca gcaatagcgg cggcaagaaa gcgaccaaag 29280

cagtaacggt taattctgcc caataatcgc gacgtaatta agcagaggct caggaagagc 29340

ctctctttta aaaggacttt aaccaatgac caaattactc gatctcgact ccattctgcc 29400

tccgaagaaa agcatcaagt tcggcggtca ggaatatccc atcgttgaaa tgactgttgg 29460

cctgttcgtc tctatcaagc agatggaagg caaagacctc cagaatatgt cgcctgttga 29520

gcaggttact gcttacgccg acctggttcg caaggtcatc ccatccgtgc cggacgctgt 29580

actggaaaaa ctgactgttc cgcagctcca gcagatcttc accttcgcta tggaagtgat 29640

tgatgaagag aacgaaaaag cggctggtga aggggcaaag taatttcccg cgatgaatcc 29700

ggggtaaaga ccgtatcgat agatctcgga ttctatttca gtcgtgtagt tgctcactac 29760

gccgtgtcgc cattagagct gctgggcgtc cctctaacga tgttctggat gctcagtcgc 29820

aacatcgacc gtctgcgtgc ggaagaggat gtccgcaacc tgcaagtcgc tcgcgctgcc 29880

caggcagatg gcgagggcgt aaaggcgttc atggagggtt tgcaactcag gattggaaga 29940

ccagtcgtaa ccgataaagt ctacgatcca cgcaaggata aggcagaccc tgacgccaaa 30000

gagcaactga tgcaaatttt tggcagagga tgacaaggga atgtcacaaa acgtagagtt 30060

tatcctgtcg ctggaagaca agcagtttac agcgtcaatc gaccgggcgg gtaagctact 30120

taccagattc ggggagcagg ccacaaagcc agctcagaaa attaacaatc tggaacgctc 30180

gttgggttcg gtctcccgca tcatcggcgt tctggagtcc aagctcgatg tcacggcaga 30240

aaaactacag gatgtagctg ccggcttcga gcttgtgtct gatgtttcgc gcaagacgcg 30300

aggcagcatt accagcctca actcaggtct caaaaccctg attgagcgcg tcgacacaac 30360

cacctcatcc gttaataagc tcaccacatc gctgcgcaag gttcagtctg aactcaatga 30420

gttttccgat tgggcaacgt tcgctggcaa gagcgccagc cgcttcggta cggaggtaaa 30480

agaagcctct gcatccgtga gcggcatgaa tacgcgtctt aacaccacga caaagcgtct 30540

cagtaattgg ggtgtcacaa cgagccaggc tgctgagggg ctgaagaaag tccgcgatca 30600

gatggatgcg gtgattggcc gccagcaact gatcagcaag ccggtacgtg tacgcaccag 30660

tagctacggt gatggcggtg gtaatggcgg tggaggtcga cacagcggtt cctatggcca 30720

cggtgggcgt agtgctgaaa gtggtgtgtt ctctggtctg cgcggcaaca ttttcttgct 30780

tggcgagatt ggtgatgcgg caagaacggt aactgacatc ctgttcggct ggcagaagcc 30840

aatcatcgaa gccgcctccg aaatggagcg tatgcgtgtc atgttgcgcg ggctgaacaa 30900

ggataaggcc aaccctggaa aagccgccgc agaggatatg cagtacatcg tggatatggc 30960

gcaaaacgcc ccgtttgcga tgcaggcgct gaccgattcc ttcgttaaat ttcgctcggc 31020

aggtctcgat cctactgacg gatcgctgaa agcactggtg gactccgttg cacgcttcgg 31080

cggcgatagc gaactgctta aacgtgctgc cgtggctgtc cagcagatgt ccggtaaggg 31140

cgtcgtgtcg atggaagaac tgcgtcagca attaggtgaa gccgttccta acgcgatgaa 31200

ggcgatggca gacgctgccg gtatcactat gggggaactg accaaagcag tctccaccgg 31260

tactgtggaa gcgaaacagg cgctatcgct gatgttcgtt ggtctgcgtg cggagaacga 31320

aaacgccgcc aaagacatga tgcaaaccta caccggtgcg ctggcgcaac tgcaaacctc 31380

ctttacgctg tttgccgatc gtgtcggtca ggcgggctat ctggattctc tcacaaaggg 31440

gatgaaagag cttgcttcca tcatgaacag cgctgaaggc atttcgttcg ctaactcgct 31500

gggttccgga ctctccacgg cgatcgacgg cttacgcgag ctggcgcagt ggctggctaa 31560

aaaccaggag ctggttatca gcctgggcaa agtcgttgcc gcaatggtgg cgttcaagct 31620

gatgcgtgcc gggattgcag gcgtgattgg cactgccggg caaatggtta acacatttac 31680

caagatgtcg accgttctcc aggctccgtt caatctgggc gcgacagctg tcacccgctt 31740

taatcgtgcg gctcgtatgg ggctggcccc aatcccatcg ctgatcttcg ctatccgtgg 31800

cgcgattacg gggcttcagg gcgcgtttgc tgggctaact gcgttcattg cagcaaaccc 31860

aattggtgca gcgttcaccg tagctaccgt ggctgtggcc ggtcttatca cgtatatgac 31920

catgctccgc agcgaaacgt ccaaagtcgt ggacgagatc cgcaaaatcc cggaggcgat 31980

gacggcggcc aagcgtgcgc agatggcagc gcgtgcagcc gagcttgaaa agcagatcca 32040

gcgagaccag caggcgctta aaactggcga aagcgtgaac tactactcca cagcggctgg 32100

ccctgtcgcc gtgaaggagt ccaaagaggt tgttgaggct cgcctgaaga aaaatcagga 32160

agagtacgaa agaacaaccg gcacgatggc gctgggtgat ggcgcagtgg ccaaacgcct 32220

ggcaaaagaa gctgccgaat cccagattga gaaaatccgg gcagataacc aggtcttctc 32280

tgcgacgttt gtgaaagccc gtcaggaggc tctggataag atccagaaaa tcaacgacga 32340

caaatcgctt tcggacgacg agaagaacaa gctgcttgca ccgcttcgcg agaaggtgaa 32400

caagtcctat ctggaaccgg cacagaagct ggtctacgac ctgtcttctc gtaaaaacgc 32460

caccgagaag caaattgccc acttcagcga catgctggag aaagcgaaga aagaggggaa 32520

caccgagcag gttcagaagc tgcagggcag catccgcggg tatcaggagc atcttgaagc 32580

tgtagctcag gagctgactc aggcggagtt cgagcgtgat agcgcggcga aaaccggtaa 32640

gggcgtaatg tccaaccagg gcaccgttct ggggttgggg acgaccgata aggcggctca 32700

gaaagcactg gcgcagtata tgcggaacca gatggactcc gcgacctacc agcgcacact 32760

gccagacggt acggcgatgc tggacttcga aggcaagccg atcatcgggc cgaaacagct 32820

caaaacccag ctgaacctgc agaaagcctc cagcgccagc tctctggaga aaatgagcga 32880

cgaggaacgt gctgccgcga tcgccgcact gaccaaagcg cgtgagcagg acgcagcagc 32940

agcggaaaaa gccgggcagc gtactgccaa tgcttctcag cgtgccgcga ggaaggaaga 33000

aaatgcgcag cgtaagctgg cggccggcta ccagaaagcc ctggataaag ccgatcagct 33060

tatggggcag atgggggaaa gctcaaaagc gaccgtgtcg tttgaccagt ctctccgcga 33120

taccaccaaa tcgctgaccg aactggccaa cgccgtaccg aatgagttca tcactcagga 33180

gatgatcgac aaagccaagt cacgcctcgc tgacctggcg aacgcgagcg acgactatcg 33240

cgagatgttc aaccgccgca acgtcgagca gatgatctcc acctgggcgc cggaatccga 33300

ttccatcatc agcgcgggtt acaagccgtc tcgtgaagag aaggtggccg atttcaacga 33360

cacctacaac cgtaatctga aagcgttgat ggatttgcgt gaccaggctt ctgatccgaa 33420

aatcgtggcg ctctacacca agcagattaa ccagctggtg gcggcaggca acaccgcgct 33480

catcaaagag acgggtacgg cgacacagaa gctggcgctt gagtacgaga atctggccga 33540

acagctggaa aacagctgga gcaacctgtt cagcaacatg acggatacgc tgaccgactt 33600

cgtcatgaag gggaaactgg acttctccag cctggcagag tccattctcc gcgacatcac 33660

caacatggtt gtgaagacgc agatcactct acctctcatg aacatgctgg ggatggggac 33720

gacggcagcg ggcagctctc agagtggcaa tctgctttct ggtgtcgcgt ctgcggttgc 33780

caaccagggc gtccggatga atgcggtcaa cggcgataag agcgtgggtg aggcgacgaa 33840

agagacctcc agctcggtct ccggtctggg gcagaccact cagcagacga ccagcgcgat 33900

tggttctgca accaacgcga tcggcaactg ggtaaatgga ctgttcacca gtactgaagc 33960

caaagacgcg gaaaccaaag cggtgaagac gtccatcttc tccatgcaga accttagctc 34020

tgtcacgggg gcgctttctg ccgcgtttgc tatgctgggc gcaaacatgt ccggctctgg 34080

caataagtgg ttgagtttcg gcgctaccat tgcctccggg ctggtgtctg cctgggctgg 34140

tggtggcttc gataacatcg gatctggttc ctccggctct aactccggat tcaacaatct 34200

caccggatcg gcatctgatg gtactggcgg cattccggca atcccgaagt tcgccaaagg 34260

cggcattttc gggaaagacg gcgtggttcc gctgcgtgct taccagaaag gtggcatcgc 34320

tgactctcca cagctggcgt tatttggcga aggggatatg aacgaagcct acgttcctct 34380

tccggatggg cgttccatcc cggtcacgct caacgcagag ggtgttaaag gcggcggcgt 34440

tttctcacct gtcagcattg aaatcaacgt caacagcgac ggcagtgtct cggagaacag 34500

caattccgaa ggcgcatgga gtcaggctgc gcagcgcatg aaggcgatcg cgcttgaaac 34560

catcgctcag gagaagcggc caggcggttc gctcaaccct aactctcaac gtaactaacc 34620

acggctgccc cggaaggggc ggtctcacaa ggatgtgaga tggaaagact gacttttaac 34680

tggtatcccg actacgagtc ggaaaagacc gtgaagccta acgtgacggt gctgaatttc 34740

ggtgacgatt acgaacagcg tcaggcaaaa gggcttaatc gcattaaaga agagtggagc 34800

cttactttta cgcgttctta tgacgtcatc aatgccgtcg atgactttct gacggcacgc 34860

gcggccgttg agtcgttcta ctggacgaac cctcgaggca aaaagatggt tgtggtgtgc 34920

gacagccata ctgtgaagcg ttatcagggc tatctcgttc tcactgcgac cttccgacaa 34980

atttatgaag gataatttaa cccactagat aagtaggtgc ttatttacta ttatctatag 35040

gcgctgacag gatgttggcg cctctttatt tcaaggaaga aacgatgggt attaaagctg 35100

atattcagag cttgtcgccc tccgcgctca ttgagctgtt cgaacttgat atgtcgaaca 35160

ccacctctgg gggcaagctg tttttccacg ccggtacaaa cgaactgatg gagccagtcg 35220

tttggcaagg tgtgtcctac gaaccgtggc caatcaaggc gtcaggcttt gataagactg 35280

gtcagggtac tttgccgcgt ccaaaaatcc aggtctccaa ctttgccgga accgtctccg 35340

ctgaagtcca ggcaaatgac tatctggtgg gttgtcgcat catccgcaag atgacgctgg 35400

cgcgttttct cgacgcggcc aacttcaaag acggaaatcc gaccgcagat ccgaatcagc 35460

attttcccga tgagatgtgg ttcgtcgagc agaagactct tgaaacccat gaggttgtcg 35520

agtttgagct gtcgagcgtg ttcgatctga tgggcgtgca actgccgtac cgccagatca 35580

tcaaaaacac ctgcccgtgg aaataccgcg gcccagagtg cggctatacc ggcccctatt 35640

tcgacaaaaa caaccagcaa accaccatgt caggcgcgga ttactgcacg aaacgctacg 35700

actcatgcaa cgcacgccgt aactactttg ccaatggcgt aatccacttt ggcggattca 35760

ttggagcaac acgttatggg taatagagct ttccctgagc ttgggtcgga cattatgcag 35820

gaaatctatc tgacagccat caaacgctac ccgaacgaag cgtgtggctt tctggtgcgt 35880

actactggcg agaaatatcg cttcatggaa gcccggaacg tgtcggagaa cccggaaaac 35940

acgtttgtga tgcacgctga cgacattatc gcagcggaag atgcgggaga cgtggttgcc 36000

atctggcact cccacactga cgaatcagct gatgcgtcag atgccgaccg cgccggatgc 36060

gaggcaacgg aagttccgtg gctgattctg gctgttcgga agaacgtcga gggcgatgcg 36120

ccatttcact tcagtgagat gaatgtgatc accccagacg gctttgagat gccttatctg 36180

ggtcgaccct atgtgttcgg tgtcttcgac tgctggatgc tgtgccgcga ctacctgaag 36240

cgtgagttca acgtcgagct gaatccgaac ccgcacctgc atattccatc gtggtacacg 36300

ggcgataccg acattctcga tcagaactac cgcaatgaag ggcttgttcg tctggcgccg 36360

gggacggaac cccagcgtgg tgacgtcttc ttcattcagt acggaaagat gcctgaccac 36420

tgcgcggtgt acataggaga cggaatgatc ctgcaccacc agatcgaccg tctgagctgt 36480

cgcgcttatt acggtggcat gtaccagaaa cacacgacgc accacctgcg tcacagagac 36540

ttactcaagg gagatgagac gtgtctgagt tagttcatgt gcaacttggt ggcccgatgg 36600

ccagacattt cggccgccac tggcatttaa aagtgcgcaa caccaaacag gcgttggatc 36660

tggtcgaagc caatcgtccg ggcttaaaag cctggatgaa gcgcaacatg aagacctacg 36720

acaagtatca catccagatc accaataagc aggggcataa gtggtcggtt gatgagagcg 36780

agtttcaaat gatggggcag tccgacaaca tcgcgaagat ccgcatcacg ccggttcctc 36840

gcggtagcgg cggtaaggct tttggttggt ttcagacagt cgtaggggca ctcgtcatgg 36900

ttgcctcatt ctggtttccc gcgctggccc cgctcggctt gtcgctaatg atggggggta 36960

tttcgcagtt aatttcgccc caggcgacca atgacagtgt aaggcaggca gataactcga 37020

actcgtttta tttcgacgga ccacaaaaca ccactaacca gggcaacccg gttcagctca 37080

tttatggtga ggaaattctg gtcggctcac aggtagtaag ttcttcgatc accatcgacc 37140

agctttagta agaagggaaa tttttgaaca tggaacagtt caagaagaag agactgcctc 37200

tcctgattgc aggtgctggc ggtaagaaaa gcagtggctc cagccgcaca ccggttgaag 37260

ccgacgatac cgtaaactcg cgtgctatgg cgtccatcct cgacctgctc ggggaaggtg 37320

tcattggcgg gctggtggat ggtgcaaagt cgatcttcgt tgatgatctg ccaatcctta 37380

acgaagacgg gtcttcaaac tttagcggta tcacctggga cttccgcgat ggttcacaag 37440

accagacgcc gatggctggg ttcgatttcg ttgaaacgcc gaagtcagtc aacatccagt 37500

tgaaaagaat gcacgacgtt acgattgcca tcgataacga tgaggcagac cgtgtccgcg 37560

tcattctgaa gttcccgtct ctgcgtagca tcgacaaaaa gaccggtgat accaacggta 37620

cgaccgtgaa gtacaaattc cagattgcca atggcgataa tgccttcaag gacgccatcg 37680

cagaagggga gagtgcttcc gaaattgcgc tgacggcaaa aaagacaggc gtctactacc 37740

gcagctatga gctaaaactg cccaagccag gtcgtgccta caaggttcgc gtgctgcgtc 37800

tgaccgatga cagcaatact cagtacatct ttaacgatac gtgggtggac tctatcggtg 37860

agatcgtcga tacgccgatg aactatccga actccgcgct ggttggcctc aaggtcaact 37920

cagagcagtt cggcagctcg atgccgtctc gttcgtatct ggtgcgtggc ctgaagatcc 37980

gcgtaccgtc caactacgat gaacacacaa acacctatat cggcgtatgg gatggcacat 38040

tcaagctgtt gtcatcttcc aaccctgcct ggattctctt cgacctgctt accaacgctc 38100

gttatggcct ggggcagtac gtttctgagt ccatgattga cctcgggcag atctaccaga 38160

ttggtcgcta ctgtgacgaa gaaattgaca atggattcgg gggcaaagag aagcgcttcg 38220

ctatcaacac ccagatcact agccgtcagg acgcgtaccg actgattcag gatatcgctg 38280

gcgccttccg cggtatggtc ttctgggctg gtggcatggt taacgtcatg caggatagtc 38340

cgtcagatcc ggtcatgatg ttcaccaacg cgaacgtcaa agacggcatg ttcagctaca 38400

agggatctgc gcgtaaagac cgtccgtcag tagctcttgt gacctacaac aacaaggaag 38460

acggctacaa gcagaacatc gagtacgtcg aagaccagga ggcgatgcgt cgttatggcg 38520

agcgtaaaac cgaagtggtt gcgttcggct gtacaagccg tggccaggcg catcgtgtcg 38580

gtctgtggct gctgtatacc gcacgcatgg agtcggacgt tatcagcttt acggcagggc 38640

ttgatgcttc cttccttatg ccgggtgaaa cggtgctgat tcagaacaaa taccgtgctg 38700

gtaaacgcaa ctctggccgc attgtggcgt tcacaaagaa cagcatcact ctcgacgcac 38760

cggttacgct gaataaagcc ggtagctaca tccggatctt gaatcaggaa ggcgaaatcg 38820

ttgagcgcga tattcttgag accggggaag acattaccaa agtgaccttc tccaaagcgc 38880

tcaattccgg tgatatgccg gtgatgaatg gcgtctggac gattaccgag ccagatctgg 38940

agccaatgcg cgtgcgtgtt atcaacgttg cccagggcga ggctcagggg acgtttaacg 39000

ttacggttgt ccagaataat gcatcgaagt acgaagccat cgacaacggt gcgacgctga 39060

tccccgagaa caacacagtt ctcgacccga cttattcgaa gccgactaac ctgcaggtga 39120

cggaagggac gtatatctcc agtccgggta acctctcaat caagctcgta gccacctggg 39180

agggtaagtc tgcggaatat tggatcagct ggcgtcgttc cgatgaaaac aacgtttcta 39240

actggcagtc cgcacgcgtt accgaagagc agttcgagat cctcaatatt gctgagaatg 39300

gtcaatacga cattcagctc tatgcggttt cgttcagcgg caagaaaacg gacatcatca 39360

gcaccgttta tcaggtgaaa ggtacgatga cgccgccagg ctctcctacc tctctgacgg 39420

ccgttggtga ctaccgcaac gtgattctga attgggtcaa cccggactca atcgaccttg 39480

atcacatcaa cgtgtatgcc tcccagacca acgatctgga aacggcgaag ttggttgcag 39540

aggccgccag caccacgttc actcatgccg gtctgggaga tagtgagacc tggtactatt 39600

gggttcgcgc ggtgaacaag cgtggcatgt taagtccgcc gaactccaat ctgggtacgg 39660

aagcgatgac gcgagacgtc ctctcgttcc ttaccgggaa gatcacctct tccgagctgg 39720

ggcaggagct gctggaggaa atcgacgcta aagcctctca ggatgcggtc gacgccatca 39780

acaaacagat ggaagagagt ctgaaagagc ttgatcagtc cgttgccgat ctggacagca 39840

aactggaaga caccagcggt cggcttgagc aggtgcagaa cgacctcaaa aatgaagtct 39900

ctggcacgct ggacaaggtc aacgacgcgc tgcaacaagt tgaggactct aatgcggctc 39960

tggtcgagtt gcaggaaacc gtttccgagc agggcaaagc catagctggc gctgtggaag 40020

cggcgcacgc tgcgctcgac aacgcctccg cgctgattgc tgaagagcgt gaagcccgtg 40080

tcgaaggtga taaggcaaat gccaaacaga ttgaggcaat gaaatcctcc gtcgatgaca 40140

gtgttgccgc cgtcgaagag atgaaaaaga ccgttgccga agtcgaacgc gccagcgcgg 40200

aagcgtcgac caatatcgag gctctggcca aaaccaatat tgacctcgct ctgcgtcagg 40260

atgaagacca gcacaagcag atggtcaata atgcgaagat cgcaaccact cagaagacgt 40320

ttgccgacga tatgtctgca atggcctcaa aagtggaaga aatccgcgca gaaattggtg 40380

aggacatccg ggcgtcgatt ctggaagaga caacggctcg cgtagaggct gacaagacaa 40440

ttgcgacgca tatctccaag ctggaagccc agctcaacga cgatatttca gcggcaatcg 40500

tttccgagca agaggcgcgt gcgactgcgg atgaaacgct ttctcgtcag atcaccacgt 40560

tgcaggcgaa agttgaaggt gatatcagcg ctgcacttac tgaagagcag attgcccgag 40620

ccacagcgga tgaggcgcta tcgaagcaaa ttacccaact gaaggcacag aatggtgagg 40680

atatcaaagc cgccgttgca gaagagaccc aggctcgaac cgatgcagat ggtgctctgg 40740

cttcgcagat cagctcgctg aaggctcaga cggcagagga catcaaggcc gctgtcgaca 40800

cagagacgaa agcgcgtacc gatgccgact ctgctctggc cgggcagatc accaatctcc 40860

aggctcagac cggcaaagat atcaacgctg ctatcacatc cgaagccacc gcgcgtgcaa 40920

acgctgacgg tgctctcggt aagagaattg atacggttaa ggctgaagtt gatggcaact 40980

cggctctcat tcagcagcaa gcgaaggcga ttgccgatac cgataagaag gtttctgctg 41040

cctggacgct gaagatggaa acatctacca gcggcgggca gaagtacgtt gcaggtatcg 41100

cgctgggtat cgacagtacc ggtttatcac aatttttggt gcaggcagac cgttttggcc 41160

tggtcaactc cgtaaacggg aagatcacta cgccatttgt catcgaaaac agcgtggcgt 41220

atatgaacgg cgcttatatc aaagacggca caattacgaa cgccaaaatt ggtaatgtca 41280

ttcagtcgaa cgattacgcc gcaggcagta gaggctggat tatccccaaa gatggtagcc 41340

ctgagttcaa caacggtacg ttcaggggaa atattgctgc aaactccggc acgctgaata 41400

acgtcaccat cgcgcagaac tgccagattc tggggaaact gcacgcgaac cagattgatg 41460

gcgatattgt taaagcctac atggttaatg gcagcagtat ttatattgca cctcaaacat 41520

tcgccagaat tatctatgtg gtaaatggtt actactataa caagccatcg gaggatatta 41580

acacctactc atggtcaaga attaccgagt atacggtaaa tggagtgaag cagcagatat 41640

atggaatgag agaaggctct aaaaatcaat ctggcttgtt tggttattac aatttgccgg 41700

caggtcagtc tgcgactgtt gatgtttata cctggcatag acagcgtaaa tacgatcacc 41760

gcgtgaatga accttatctc attctggtgt ttaaggctta aaaatggaga aggatattat 41820

ggacgaaacc cctgtcatct ctgctgtaag gaacgcagtg cgcagtctta gtggcggtat 41880

ctcttgtgag attcaatttg atggccttgt tatggacgat ggtgtaaccc ctttgttttt 41940

gccatacacg ttgtcggaaa gtgacacatc acctttggcc aagaaaatac tggaggctct 42000

ggagtcggaa tccagtggtg gtatcgctcc gtaccccgaa caaggcgagt acatcgaaag 42060

attgaaagtt gagaaactgg cagtaattaa tgactggcgt cttcgtcagg agtgtcgcac 42120

cgtttatttc gaatggaacg gccaccgctg ggacgcgaat gacatttcca aagaacgttt 42180

ggatatctcg cttaaagcag cggaaagcgg tctccctgac aatttcttct ggaccgatgc 42240

ggataataac gatgttccgg taacgcagga gcaactgaag gaattaggga tgagaatgac 42300

ccagacgttg ttcgaccgca agttcggcgc ccacgaacga cagagggtga tgaaaaaaga 42360

cattctggag atgtgtgatc ctgagctaat caaaaattat caggtcgggt ggggggatgg 42420

ctctgctcgg cggtagacat ctttctttat atcggtaaaa ataagtaagt gattacctat 42480

ggcgagcagg gatgcccgcc tttacaagga gcgaatatgt ggtacaggga aggtactatc 42540

acatttacac agggaagtga cgcactttct ggcactggca cgtactggaa tgtgaccgcc 42600

aacggcgttc tgccgggcat gatcgtcatc ggccctgaca acaagttgta cgaaattaag 42660

cgcgtaatta gcgacacaag tctgattctc gcagagccgt acacagggga gacccagaag 42720

gaagttccgt gccgcatcat cacaacctat gagggcgact taacgcagtt cagcgcacgt 42780

tttaccgcgc ttatgacccg tatgtcagcc gactcgaaga cgatgcgcag ctggttgacg 42840

gcagttgatg aggtaacgct tgagcgtgaa gacggtacgg aagtgaccgt gaagtcgctg 42900

acgcagatcg tcgatgagca caacgcaaac cagaaatggt atacggataa tgcagacgct 42960

attaatgcgg caggcgagaa ggctcgtgag gccgctgagc gcgcattagc tgcggcgcaa 43020

agctcttcag aagcaagagc aaaagcagat gaagccgctc aaagttcagc ttcagcatct 43080

gagtataaaa ctgcggcaga gctaagtgcc gctgcatcaa aagcatcgga gcacggcgcg 43140

gcagaaagcg cagcttcatc gaaggcaagt gcctctgcgg ctaaaacatc tgaagataat 43200

tctgccgcgt cagagaccaa tgcggctgaa agcaaggctg ctgcggcatt aagtgcgtct 43260

tcttcggcaa atagcgcctc agaagcattg caatacgcgg agtcagccaa gacctctaaa 43320

gaggctgctg ctgcttcaga agcagcggca gccaatagtg aaaatgaagc cagaacctca 43380

aaagataccg ctgtagcggc tgcggcagag gcatcagcta atgccacatc agctgatgcc 43440

tccagacatg atgtcgatac caataaagcc gaagtatcga gaatgaaaga tgaagttttc 43500

gctgctaggg actcaacgat tcagtatagc gaagaggcta aaacagcggc tgatacagcg 43560

gcaagagaag cagccacgaa aacatctgat cagctcctgt cggcggttaa atcagaggcg 43620

gaaaaggcaa acagtgctag cgcaagtgct caaggttttg ccgatgacgc caagcgattt 43680

agagacgaag ctcaggaaat agctgaaggc agcaaggtaa acgatgcaac aacctcacag 43740

cagggggttg ttcagttgag tagtgcaact gatagcgaga gtgaaactct tgcctctaca 43800

ccaaaagctg tgaaaacagt catggatgcc gttgctctaa aggctcctat agatagcccc 43860

gcgctatctg gcgcaccaac agctccaact ccggcaatta ctgctgctgg acgtgagatc 43920

gcgacagccg cgtttgtggc ttcaaaagta gcacaacttg ttggctcagc gcctgaagca 43980

ctggatacgt taaatgagct ggctgctgcg ttaggcaatg atccaaactt tgctacgact 44040

attacgaaca tgttggctag aaagcagcct ttggatggaa cactaactgc gctttctggt 44100

cgttcacctc aaggggtaat tgattatctt ggcttgttga atacggttaa cctggcggct 44160

ggctcaattc agaaatccca gaatggggca gatattcctg acaaaagatt atttgtgaaa 44220

aatataggtg cagttagctc cgccagaatt tcgtttgtta aggaatccgg gtggtataag 44280

ttagcgacag taacaatgcc tcaaggagct tcaaccgctt taattactct tattggaggt 44340

gctggataca acgcggggct ttatgaccag gcagcgataa gcgaaatagt gttgcgatca 44400

gggaactgga atcctgttgg catcacagca acattatggc aacgctcacc agcaggtgct 44460

caaggggtgg cgtggataaa tacatcagga gatgtttacg atatttatgt aaacgttgga 44520

cagtactcta ttgatgttat tgctctgagc gattgtacaa ataatgcaag catagtgttg 44580

ttcggcacac cagagtatgt ggcgaccaaa cctgcaagtt ccacgaacgg cgcaaattat 44640

atattgtaca gtagtgttct accaccgcct gagtcatatc cagtaggtgc ccctattccg 44700

tggccgaacg atgtggcccc gtctggtttc gccatcatgc aagggcagac gtttgacaag 44760

agtgtgtatc cgaagctggc ggccgcatac ccatcaggtg tgttacctga catgcgtgga 44820

tggatgatta agggtaaacc aacttctcgt gcagtgttgt cactggagca agatggaatt 44880

aagtcacatg cgcacaatgc agccgcttcc agtacagatc ttggtacaaa accaaccaca 44940

acatttgatt acgggacaaa aacgtccagt ggcttcgatt atggaacgaa atcgtctaac 45000

agcactggtg ctcatgcaca ctcgctgtct ggctctacat cgagttcagg tgcccatgcg 45060

catacggtaa ctgctcatac tcagtatcca agatctacag attcgaggaa ccagaatgct 45120

gtcggtaagc aatacaacac acagcagact acagccaatg ctttcaatgt ctggacaagt 45180

agtgcaggtg atcatgccca ctcaatctcc ggtactgctg tcagtgccgg tgctcatgcc 45240

cataccgttg gtattggcgc acatgctcac tcattgagta ttggatcaca ctcgcattca 45300

gtggcaattg gggcgcactc acacactatc actattgccg cttgtggtaa tgcggagaac 45360

accgtgaaaa acattgcata taactacata gtgagactcg catgattata ttagtttttt 45420

cggcacctgt tgcagaaatg gctgatgctt gtacatgtga atttggatat agcgaaaatg 45480

tcgagataat ttacaggtcg ctcgaagcga gcgctgagtt tgactgcatt gtcagtgcta 45540

cgaacagttt ggtcaggtgg atgggagcgc gaatgctgaa tatatcgggc aaggttttta 45600

ccaatagttt gtgaggcttt tggttggcgt gcatcacgtc cgagacatca ggggacaatt 45660

ctaatgcgca ttcttttaaa tctgtatcgt taaaggagtt gacgaaatga ctttcaaaat 45720

gactgataaa gcgagaactc tcaaagtgta caatctgctg gaggggacaa atgaatatat 45780

cggagttgga gatgcctata tcccaccgtt tactgggtta ccggccaact gcactgagat 45840

tgaaccaccg acgactacgg aagggtttgc cgcagttttt gacttcacaa agcaagagtg 45900

gagccttgaa gaagatcatc gtggcaaaac gctttacagc acagaaaccg gtgaaccggt 45960

gttcatcgct gaacttggcc cgttgcccga aaatgtaacc tacatctctc caaacgggga 46020

ataccagaaa tgggatggtt ctgcttgggt taaagacgaa gaagcagaga agactgccct 46080

tgtcggtgaa gccgagcaga ataaatcggt gctgatgaag aacgtcagcc aacaaatttc 46140

cttgcttcaa gatgcgattg atctggatat ggcaactgat gaagaaaagg aaacactggt 46200

tgcgttgaaa aagtaccgtg tcttgcttaa ccgagttgat acttcgttgg ctccagatat 46260

tgactggccg atattgggaa acgaggaaga agattcggca aatttgatta aataaagtag 46320

gtaggtagtt atttatataa tgtgatataa atatgccatc ccgatttgac tattcatcag 46380

ggtgtcaacg acggatgaaa agtgatccac ttatatctcc accaacggcc caatattgat 46440

ccaccgtttt actcaggatt agcttctgct ataaccccgg cctttcgttt ctgtctgagt 46500

cgatagcttt ctcctttgat ttgaacgaca tgtgagtggt gtaagatacg gtccagcatc 46560

gctgaggtca gtgctgcatc accggcgaac gtttgatccc actgcccgaa cggcagattg 46620

gatgtcagga tcattgcgct cttttcgtaa cgtttagcga tgacctggaa gaacagcttt 46680

gcttcttcct gactgaacgg cagatagcct atttcatcaa tgatgagcag gcggggggcc 46740

attactccac gctgaagcgt cgttttataa cggccctgac gttgtgccgt agataactga 46800

agtaacagat ctgctgctgt tgtgaagcga actttgatac ctgcacggac tgcttcatag 46860

cccatcgcta ttgccagatg ggttttcccc acacctgatg gccccagtaa tacgatattt 46920

tcattacgtt ctatgaagct gagtgagcgt aacgactgga gttgcttctg cggtgctccg 46980

gtggcgaatg tgaagtcata ctcttcgaac gttttcaccg ccgggaaggc tgccattcgg 47040

gtatacatcg cctgtttacg ttgatgacgt gccagttttt cttcatgaag cagatgctcc 47100

aggaagtcca tataactcca ttcctggtct actgcctgtt gtgacagcgc aggcgctgcg 47160

cttataaggc tttccagttg caactgcccg gcgagcgcca tcagtcgttg atgttgcagt 47220

tccatcatca cgccactcct ctgcagaatg agtcgtagat ggagagtgga tgatgcaggg 47280

ggtgtttgtc gaagttcacc agattttcat caagatgcac gtcatactct tttttctccg 47340

gaggcagtgc cagcatggac tgctgctctt cgagccagcg atcgcaggga cgggcctgga 47400

ttgtttcatg ctttcgttgg ttagcgacat cgtgcagcca gcgcagaccg tggcggttgg 47460

ctgtttcaac atcgacagtg atccccatcg ggcgcaggcg agtcattagt gggatgtaaa 47520

aactgttacg ggtgtactgc accatccgtt ccaccttacc tttagtctgt gccctgaagg 47580

ggcgacacag tcggggagag aagcccatct ccttgccgaa ctgccacagc gaaggatgga 47640

accggtgctg accggtctga tatgcgtcac gttgcagaac cacagttttc atattgtcat 47700

acaacacttc gcgcggcaca ccaccaaaga agcggaacgc attacgatgg caggtctcca 47760

gcgtgtcata acgcatattg tcagtgaatt cgatgtacag cattcggctg tatccgagaa 47820

cagcaacgaa cacgtgaagc ggtgagcgac cattacgcat agtgccccag tcaacctgca 47880

tctgtcgtcc gggttcagtt tcgaaccgaa cggcaggctc ctgctcctga ggaaccgaga 47940

gagaacgaat gaatgccctg agaatggtca ttccgccacg atatccctgg tctctgatct 48000

cgcgagcgat taccgttgcc gggattttgt aaggatgagc atcggcgatg cgttgacgaa 48060

tataatcccg gtattcatcc aggagtgaag caacagcagg tcgcggcgta tattttggcg 48120

gctcagattt tgcctgcaaa taacgtttaa cggtattgcg ggagatcccc agttctctgg 48180

caatcgcccg gctactcatt ccctgcttgt gcaggatttt aatttccata actgtctcaa 48240

aagtgaccat aaactctcct gaatcaggag agcagactac cccctggatc tgatttcagg 48300

cgttgggtgt ggatcactat tgcaccgttc gttacagcaa cgagtgattc gacagcagta 48360

acggccgcgt tcccggtcag ttcgcgcgcc gccagcttct ccagcagctc tactaccttc 48420

tggtcgctgg gtacggacgt atcgagtggc tcggccactt tgtacttctt cacaccgaat 48480

cgaatgaatg ggttgagcat tagcgagacc atgctctgct caaattcatc aaggttggcc 48540

agcgcctctt tcttggcgtt ggttcccatc gtttttatgg catccagctt gtgctttagg 48600

gcgatcagtt tttccattag tgtttaacct ccatcggtcg ctcgggagtt ttcatgtgtt 48660

ttctttggtt gcttcttcaa tgagtgccgc gtacacgtca gtgacgggcg ccagtgaatc 48720

ggtggacgtg gttttgggtt tggctggttc tgttttcttc gtgcgtttaa ccagactgtt 48780

aatcgtcatg gtgttgcgct tccgggtgag cattctggca tggtcgtttt gctcttccac 48840

ttctttgata agcgcagtca tatcgatgaa gtagagctgt tcgcctttgc ggatctcttc 48900

gaccatcatc ttcagcgcct ggcatttgcc agcagcaatg gccgcagcgc aggacaggaa 48960

cgatgtagct gggagacgct tctctttgta ggcgaggatg gtgtgctggc agactgtata 49020

gctgcaatgg gcctcatggc cgttgatctt cacttccgga cagcacagcg aataaccgtt 49080

gtttccggag atagacggga ttttcgacaa atctgttctt gtggacatgc ttctaaccgt 49140

agtcgtgtac ttacttattg agcgcagttt aaaaaagccc caccaggggg ctaaatggtt 49200

tatcgaggct taccaggtcg cccagccagt cattttgtcc tgggcggctt cgaaccggta 49260

tggctccagt aaatcgttgg catggtggac ggcgtaggat tttgcctcct gtttaatcat 49320

cggcagctcg ttggccaggc gtgccacttg ccctgcaaaa ccggctagca caccgtcaca 49380

tgcctgaccc gcatcgacaa tgatacgcac caggtctaag tcgctgcggc acatatcgca 49440

gatgatgccg tattccacct cacgaatgcg ctcaacggct tttttggtgt cgccactgac 49500

caccaattcc agcaaaccag gtggggttgt cagatctgta acgcgctcgg taacttcagg 49560

cagttcgaca atgctcagga acgccgcgat tgacgggtca tcctctacac cagccctgcc 49620

tttgatcgcg cgaagagtcg cgtcgacaat atcctcaaac cgttcacctt catcgcacac 49680

cgcctgattg gtgtagacaa cgcggccgtc gtaccatgct ccagcacgta cttctaccgt 49740

tgcatccttc atctcgcgag tgaacgtcac aagtgccgcg cgtttctgtt taacaccagg 49800

cagctccgga gactctccaa aacgaaccca gacccgcatg tatttcgacc cttccgaaag 49860

aggtgcggtg ctcacagacg tggcgatgtg tttcagcgca gtctggatcg cctcaccgat 49920

aatcttctgg cgctcttctg tatcaatttc tacgcctgat ttgtcgatga tttcggtaac 49980

ggacttctga atatctgctt tcataaaggt tcctcaattc cttcgtcgcg catattctta 50040

cagaaaatta agtaagtatc tacttatcga tttaggttca ggaaaatcca tagtccattg 50100

cattacaagt tcaaatattg accaaccctg attcgacaag tgctacctta tcggtttata 50160

tgctatgggg cattgttacg cgtaaatgag tagcctgagc catgtctttt tctataaact 50220

ccatgataga aaccatctta ccttgctgga ttatgtatgc ctgagaaaat ctttaaagcg 50280

ccttgcccta catgtagagg gacatgcaat acgttagttc atggtgaaat acaaaaagag 50340

tggagtaatg cggtagacag ttttaattta tcatatgggc aagatagtca taagcttctg 50400

gaatgttgcg ggtgtggcac tgttttttac tataaggact catggggtag tgagcatggt 50460

gataatgata tttacggaaa attcacccct acacatttta ttgaaacagt ccctgcgcca 50520

gagcaaccaa aactaaagcc agactggttg tttgaaattt acaaaaaaga tcaaatccta 50580

ttttttattc ttgatgaagt atatacagca tatgaacacg gatcgttcat actcgcctct 50640

acagggctac gcacggcatt tgatcactca tgcgctcata ttggcatacc taatgcctac 50700

acaatggaac aaaaagtcaa agatgttttt gtgaaaggtt atgtgagcga aaccgaacga 50760

gatcaactca gaattgttat agaagctggt aacgctgccg cacatagggg atggagacct 50820

gacaaatctg cttttgagtc actattacat gttgctgaaa aattcattca gcaagttata 50880

ctaagagacc ttgagataga aaaaatcggc gaaaagatac caaagaagca aaagaaaaaa 50940

ggagactgta aacaatattg tgtaattgcc tgtttttgat atcttcactc caacaacgga 51000

gacaggcaaa ttatggacga aaagaaactt aaagcacttg cggctgaact ggctaaaggt 51060

cttaaaaccg aagccgacct taatgcattt tctcgtatgc taacaaagct taccgtcgaa 51120

acagcgttaa atgcagagct taccgaacac ctcgggcacg agaaaaatac ccctaaatca 51180

ggctcgaata cccgcaacgg ctattcgtcc aaaacactgc tatgcgacga cggcgaaatc 51240

gagctgaata cgccacgcga ccgcgaaaac acctttgaac cgcagctgat aaagaaaaat 51300

cagacgcgta tcacacagat ggacagccag attttgtccc tgtacgccaa aggcatgacc 51360

acccgcgaaa tcgtcgccac cttcaaagag atgtatgacg ccgatgtgtc tcccacgctg 51420

atatctaaag tcaccgatgc cgtaaaagag caggttgctg aatggcaaaa ccgccaactg 51480

gatgctctgt atcccattgt ttatatggac tgcattgtcg taaaagtccg ccagaacggt 51540

agcgtgataa acaaagcagt gttcctagcg ctgggcatca acactgaagg tcagaaagag 51600

ctgctgggca tgtggctggc agaaaatgaa ggtgcgaagt tctggctaag tgtgctgaca 51660

gagctgaaaa atcgcggtct tcaggacatt ctgattgcct gcgtggatgg cctgaagggg 51720

ttcccggatg cgataaacag tgtttatccg cagactcaca tccagctgtg catcatccat 51780

atggtacgca acagcctgaa atatgtgtca tggaaggact ataaagccgt caccagcggt 51840

ttgaaaatgg tgtatcaggc tccgacagaa gaggcggcgc tgatggcgct ggataagttt 51900

gcggaggcct gggacgacaa atacccgcaa attagcaaaa gttggcgtac gcactgggaa 51960

aatctcaata cattcttcgg ctatccgccc gatatccgca aggctatcta caccacgaat 52020

gccatcgaat cggtgaacag cgtgatccgt gcagccatta aaaagcgcaa agtgttcccg 52080

acagacgact cagtgcggaa ggttgtttat ttggcgatca aggatgcatc aaaaaaatgg 52140

agtatgccga tccagaactg gcggttagcg atgagccgtt ttattatcga gttcggtgac 52200

cgcctgagcg atcaccttta atacggtggc agttacacag aattatggac aggctctgtt 52260

ttttgccaca cgtaaacgtg aaattgaaaa ctatctttgc ccagatctaa taagagatga 52320

gacaggggtt caggtttttt tcacagacac atgcgacgca aaaaaaccat aggaagggca 52380

accagcacga aacctaacga cgtactggac aggttctggc ccttaatgac tgccgaaaaa 52440

atcataaaat gctctactta tagagatgat aataatgaca aaattgagct tatagacatt 52500

cttgaaggca ttgtttcatt agtcgattga tcgtgaccta cgttgcatag cggtgtgtca 52560

gttaagcctc tgtgtaacgt tattgtgctc aaaaaatgag cttaacgaat ggaagggact 52620

tcccctgatt atgaacctga ttaactcttg tgcaatcatg ggataaatat cactccggag 52680

ggattcgtta tgaccatcac tactgtcggt atcgatcttg ctaaaaacgt gttcgctgtt 52740

cactgcgttg atcagaatgg taaaacggtt ctggttaagc ccaaagtatc gcgtgctgca 52800

cttcctgagc tgattgcagg tttacctccc tgtgttatcg ggatggaggc atgctccggg 52860

gcgcactact gggcgaggct gtttcgagag tatggtcatg aaccgcgcct gatggctgca 52920

aagtttgtat cgccttacca catggccggt aaatcaggaa agaatgatgc tgccgatgct 52980

caggctatct gtgaggctgt ccgtcgtccg catatgcggt ttgtgccagt gaaggacgaa 53040

agccagcagg ctatgcagtg tttacatcgt acccgacagg gttttatcga agagaaaaca 53100

gcaacgtata atcgcctgag aggattgatc tctgaatttg gcgtcatcgc cccgcagagt 53160

actgatgcct tacgccgcat ggtttctgag cagaagaatt ctttaccgtt ccaggttcag 53220

caatgtattg atgatttgct ggagcacgtt gatcgcattg aagccaacat tgctgactat 53280

gaccgaattt tgtcccgcat ggccaaaaca gatcaccgca gtcagcgact gatggagctg 53340

aagggagttg gccccacaac ggcctgtgcg ctggtcgcca gtatcggtaa tgcacatgat 53400

tttaagaatg ggcgtcaact ggccgcctgg ctggggctca cgccttcaca gtacagcagc 53460

ggcggaaaat caaagcttgg caggataacg aaagctggcg attcgtatct gcgaacactg 53520

ctggttcagg gggcccgttc agttctgatt ggcgctgata aaaggactga ttctttcagt 53580

cgttgggttt gtacgctggt tgaacgcaga ggatactggc gtgctgttgt tgccatcgcc 53640

gccaaaaacg caaggctgtg ctgggcatca ttgcattacg gtgatgattt ccggctgtac 53700

tcagccagct aaagcactaa gtagtataac catctgacct gcaactcgtt gatgataaag 53760

ggttagaccc cgtgaggcct atctggctat tgtacaggat atacgtatcc gcttaacgaa 53820

caagaacctc acgcgcgtct ttcatcaggg cccgaatcga tgacgattca tcatggccgt 53880

ttatagtacc gcagtctctc ccctttattt ttactgaaga gcagacagaa accttgaata 53940

ccgacgttga catgccgggg aagcccttat agtacaataa ttttcgatat ccaaactgac 54000

cccaacttca agtttgcctt tctgttcacc gagttgaatt cctttctcga tgcccttctc 54060

gatacctttc tgttcaagct gttgtgcgat ggtcatgagt gcgtctccat gctgcggcac 54120

acgctgtgcc agttcgcgaa caaaggcttc ggagtcagca gactcgccgg cctgtaataa 54180

atagtgtatc agcgccatta cctgcggtga agacagataa tctgccatca gcaacgtagc 54240

cagtctgtcc gtcagggtgg ctatatcacg ttaagaaggt ttgctctgcc gccagcggca 54300

ggcctatagg gtcaccacca aagcacgcca gagtgctgaa gtatcgccta acctattgaa 54360

tcagaatttt aatccactgg gaattaacca ggtgtgggtg agcgatatca cctatcgtgt 54420

gcccggagtt cagggcgagc atggacgctc aaatgaacca cgagtctgtc tggaatattg 54480

aaccggtaac tcacgatgag aaacccaaca atcctaccgg gtgtgacggt ggagaacctg 54540

agcggcagtg acctgcggca tgcccgcagg gtgatgtaac ccgctgacaa cggggattga 54600

ggcgagatca ctaagccgag atgatcctca aggttaagtg ctgaaaggct gaagaacatg 54660

aacccgttaa tccgcctctg tgggttgaaa atgtcaccac ggcctatgtg atctgacagg 54720

ccgtgcagaa ggcaccgaca ttgatagata tgcagtgttg gtcgaaagtg ttttgacatg 54780

taagcagaac accgggacag caacgtctat cacgctcgcg ttgctgactt ctgccaactt 54840

gcggcaagca aggacaaaga gtgcgacggg cagcctcctc agtatgtctg agtccaggca 54900

ggtgaaccgg ggaaggtcag cgacggatgt taagggggca tggctccgat gacgcgctgg 54960

ctggcggagc ttccatagta gtccgcgatg gggaaagccc attacatggc gaagggaagc 55020

agtttaaatg tgtttgcgac gtgaattaac tgacctaatg aggtgaagac ctttgataat 55080

cagcgaaatg caacgcaagc ttgccacatg ggcagccacc gacccgcccc gacgggttga 55140

acggctgctg cgtctgataa cacaaccaga atggctggct gaagcggcgc ggatcacact 55200

tgcatcaaag ggggcgcata cccccggcgt tgatggtgtg aacaaaacaa cgctacaggc 55260

cagactggct gctgagctac aaatactcag ggatgaactt ctctctggtt gttaccaacc 55320

tctgccagcc agacgggttt atatccccaa aagcaacggc aaacagcgac cgctgggtat 55380

ccccacgctg cgggatcgta ttgttcagcg ggccatgctg atggcgatgg agcctatatg 55440

ggagagtgat tttcatactc tgtcatatgg cttccggcct gaacgcagcg tccatcatgc 55500

gatcagctca ccgattgtgg ggaaacacga gggcgctggg taattgaagg cgacctgtcg 55560

tttaacttga ccagaacagt ccagtatggt cgttattaga aagtccactt cgctaagaag 55620

acttggggcg catggcacat gcgtaaaata tctcggacgc tacctaaaac gaccaccgat 55680

gtcggcgtca aaactgcgac gaaacagaga tgataaccat catgattatt agcatgatgg 55740

tttatgtgat ttatgactga ttattactta ctagtgtatt ctagtcatca atttgggctt 55800

aattttggaa atgcatgtgg gctagaatat ttccacaatg gttcccagta agatttcatt 55860

aattcattaa ctgcatcttt tccttcgact aaatagtcaa actctgacag ataaccggga 55920

taaagattat ctgatccaac aacgtacaac tcatcgtcaa taatcattaa tttggcgtga 55980

ttaccaggtg caacagggac tttaggatag aaaagtccac tacctttaat tgctgacatt 56040

agtgcactac caataatacc ttgatgcggg ggtttttccg aaagtggttt ttgcttaagt 56100

gttgcagtat aagcgctttg ttctaaatca ggccacttgt aggtttcgcc ttcaattgta 56160

ttttcatcag gtactttatc tgtaaagaag aatggtgcaa tcaatattct ttttaaggca 56220

tcagcacggc taccatcagg atcgtctaat acttcatcgg tatcaatatc atgggttagg 56280

taatacttaa ataattcata ggtccgttct gctccagaac caaatgagta ctgatcacca 56340

gcagctccag ctgctgcatc tagagcagag actacaacat gaatatgaag atctttattt 56400

tctaacaaag cctcaataat ccaattacac gtaaagtggt ctttccattt ttttttccaa 56460

gcactcacga gatcttgctg tgaaattcta attatgcgct tagcattttt tatcagttgc 56520

tctttcatta tttcagaccc tctttggtag tcatgctcca tattaggtcc tgtccaatat 56580

ttacctactg ataaaactct gtctgctttt ttatactctt ccatgttttc gtattcacta 56640

atacgagtcg ctaccttctg attaaagttt tcatgcaagt tgagtaggtc ctcttgccgt 56700

tgcttcatat aattcatagc aactgagctt ttaagcggat cttcaggctt atcatagaac 56760

tttgttccga ccgcccacat catgctttca taatcaaaat attctttttt tagtaaatct 56820

gaattacatg accatagttc gttaagatat agctgggagc cataagcaga agaaccatga 56880

gtgataattg atacatcatg aacaggtgga taatttctaa atagatccat gttcatgtta 56940

tgtccaccaa caagagcttc agtaccatct gaggccatta tttttgtgtg attccatgtc 57000

attcttgtat cgttgattgg tgggaaatca ggatacacgt ttctcataaa tgatgtagcc 57060

aacccttctt ctattctaaa gaaacggcct agccaaattt caggcatttt ttcccaatat 57120

tgtcctcgct ccttaattag ctgaattaac tctgatttaa aagcaacaaa gtcaggggag 57180

ccatttgttg cagcagataa cccattcata aatactgttg gagattggcc gaaaagaaac 57240

ctatactgag ttggctgagt tcgccccatt tttttcgata aggattcatc aatggcctta 57300

aaaatcactt ttcgccactc tgcatcgggg ctattaagtg atgatatatc acagcgataa 57360

cgcgaattcc gcagtacttc agtcattgcc cctgcaaact cctcttgccg taagtaagat 57420

tgctgcatga tttctttacc aaatggggct ccccaagcat ggggggtatc cagaagtcgt 57480

atataattaa tgttacttag atgatgaaag tagtttccaa tattattaat gacattatct 57540

atttgaagca tattttatcc tttgtttatc gatgtgttaa taaatatcgc cgttgcagca 57600

attaatagcg gggagatagc ggggtacttt acgcccatag tcggttaaac tcaacctgat 57660

attttcccgc tatttcaggc gcaccacgta tgacgagaac attttctgca ttgtgagtat 57720

cgccattggt ggtgtaattc attgaccctg tttgtatcgt gtcaccatca gctatcatca 57780

ccttgttatg atgaattgaa tagttgttat ttaaccttac cggaacatgt tgttgtgcca 57840

gatagtgaat ggctgaatag ttcagacggt tagctttggc atcagcaaca actcggacgt 57900

taacccctcg cttttgagcc gagacaatgg ctgtcgagat ctgcttactt gtaaaagtat 57960

aggcttcaac atcgagcgag gattgagcat tattgaccac gcttaataca ttctctaatg 58020

cagtgtgaga aggagagaat ccaacattaa aggacggggt tgcgagcgcc gaagcgctga 58080

ccagtacaaa aatgatgact gagagtttaa atctcatgag ttatgtccaa agtttgtagt 58140

tcatccatta tgtaaaaccg aaaaaaaacg cctatgtttg gcttgctgta tcgagctttg 58200

gcttttatgc ttcgctcggt ttccattgtg gcgatccgtc ggccgttcgg taaggtaatc 58260

agcccatcag gacggtgctt gaccttaaac tgatttaaaa agtattacgg tcacttttaa 58320

tctaattttt agccccttct tgggcgaata tcaagtgaaa acgctgttgc gataaggtct 58380

gctaaaaaac aggcttaccg tacatttttt gaatattaaa cataatgtag gctgcatcac 58440

catataagtc cacatacata gtaatggtat gcgatgccta cattttgtga ctaactttgc 58500

ataatcatat aagttttata taaaagggtt tgaggttcag tagaacggtt ttacatctta 58560

atattttgta tgataaatca tagtgttata gataacaaaa aacaggtgca taggggcgtt 58620

tttttagggg tctgaagcta agtcaaacga aaactcacgt taggcgagaa aggtcgtctg 58680

aaaaatcgat taatggacag cgatgtccgt taaatgctat ttaccgatta aaaagacacc 58740

gttttaggcg catttttcac tgtctataat gttttgattt atcggacaaa aagcccttaa 58800

cgtgtgaaac cgttccgttg agcgtcaaac ccctattaac gtggaggacg tatcaatgtc 58860

gcgtcgtggt ttacgtttat cacagctgcc accggtacgt tcggaaaagc caaaaccggc 58920

caaaacgtcc gcgcagctca tggcggaaga tacgctgcgt gagttaattg ccgcccgctt 58980

tgccgtggga aaaccggtta tccacattca tgcaaactgg aatgatgcgc tactactgcg 59040

ggtattgaaa gaagcgatac accaagctaa aggcccgccg tttgtggtgg taccaccgca 59100

tctaaatgaa catgagaaag agaacgacta gcgagcgcta gtcgtttaaa tgattagtgg 59160

cggatttgcg ccaaatcgtc ttcagaaagg ccggttgctt cttggaccga ctcaatcggc 59220

atgcccattt ttaacaaact gcgtgccact tcgagtttgc ctttctctat gccacgttgt 59280

tcaccgagtt gaattccttc agtacggcct tccatacgac ctttttctat gcccttctgt 59340

tcaagctgtt gtgcgatggt cataagtgcg tctccgtgtt gcggcacacg ctgtgccagt 59400

tcgcgaacaa aggcttccga gtcggctgac tcgcctgcct gtaataaata gtgtatcagc 59460

gccatcacct gcggtgaaga gagataatct gccatcagca acgtcgccag tctgtccgtc 59520

agggtagcaa tatcacgttg atgaatatgc ttttgcagca gcgtcagtgc cgccatgctg 59580

cggtgctcca taatatcatc gtctggaata accgtcacat caaccagtgg aaatgcaccg 59640

ctatagagtt tatgtgccaa ctcagggtcg tcaaactcat ctaaccaccg cgtggagtac 59700

ggataaggac tgcgtttacc cacgtaaaag agcaccggta tcaccagcgg cagcttagca 59760

tggcccgctt caaggtggcg ttgcatggca gcgatcgcgt aacgaattaa gcgaaaagcc 59820

atatgcttat cgggtgagct ttgatgctcg atcaacacat ggacgtagcc ctcgccttcc 59880

acggtatcga ggctgtaaag cacatcgctg aagtactgac gcaaatcatc ttcaacaaag 59940

gagcctgact ccagctttag cgtgctgagg tcgcagatag cgcgtagctc agcgggtaga 60000

tgcaactcca taaagtcacg tgcaatctcg ggctgggtga gaaactgcct aaatgtggca 60060

tcatggggtg tgggggtact gtttttcttc ttcatcagct cagactctga aaaatgatga 60120

gtgaatgcta tcacaatcaa agcaatacaa gatgttaagt ttacccctca gcttgctggc 60180

agacgcggat caccgtcatt ttggataccc ctgcgagacg ggctgtttca cgcaatgact 60240

taccatgcaa taggcgtagc gttcggatga gctcgtgttt ttgtgcatca gccaccctgc 60300

cccgatattt accttccgct ttcgctttgc tgatcccttc cgcctgacgg cgacgtcgat 60360

cctcataatc ttttctggat atagccgcga gcatatccag catcatgcca ttaacagctt 60420

tgagcatgct gcgagtgaat tcatcgctaa cggcgttatt gagcgccaaa tgactggttg 60480

gtaaatcaag actcacgata gacagctgct tatccgttat ctgctttctt agcgcttccc 60540

atcctacgtc gtccaatcga gaaagcctat ccacttgctc aatgagaata atatccccag 60600

gctcagcctc ttccaaaagt tgcacgagtt ttggacgtgt catcgttgcg ccagagatat 60660

tgtcgacata ccagcctgca attcggtggc catgtaggcg agcaaaattc ttcagtgcat 60720

tttttgcgcg agtggcatct tgttcagagg ttgatgctcg cagataacca aaaatgagca 60780

ttttttagcc ttgaggtaac gtttaagtag tcattttgtt aatggtatca cttatgtggt 60840

cacattgata tggaatacca tgttttaatg cggtatctca gaagtatacc cgaatgtgac 60900

aggctgacgc gcccgtaggg cttatccaac ccttcgcctc agatgcaagc tctgaacaga 60960

ctcacggttt tcgtttctgg tcaaattcta attaggcgtt taaagagaag gttttgtata 61020

tcctgcctgt gggatagtat tgcgtgtgct gttattacat tatcctccac tgagtacaat 61080

actctgtagc cgtcaggggt gttgcactca cgatatttag cacaacctat cttgagtaac 61140

tccgggcaga cctgacaccc aagtggaaaa tcactgactc gtttttcgaa gtgctcaatg 61200

atgccgctga tcacttcctt tggttctgac tcgatatgac gtaagtggct cgcaatatca 61260

tcaatgcagg ttttgacagt tctggtgtac tgaataacaa tcgccattac agacccgcca 61320

gtagttgttc tttactgaaa atattgccgt ctgccttatc ttgctctgaa agcgtcagca 61380

acttcagtag tgcaatcgcg ttctgtcgct cctgttgcgc gtcgtatgac tcaataacat 61440

atgccggaac cccattttga gtaacaagaa ttggttcttc cagatcgagt gacgctgcgt 61500

tttttttcac atagctaatg gtttcaattt tcataacaac ctcacataac aaagaggttt 61560

aaatatagtc tatatttggt cttgttgcaa caatttctgg acagaatgac ctgaatgtcc 61620

tagctgtgta gtgattactt gttaccacca taccctccac cccctcgcct gctcagaaac 61680

gatgtctaac tgcgcggttt gatgtgaatg atggttggat acgtacaata atttaatgac 61740

aatacaaaat atgttgtaca ttttttgtgt gtatgtacaa tgtgattgaa ctttataggc 61800

aatatatggg cagggaatct atctcagggg aaactatgaa acgagattac ggtagtgtcg 61860

gtaccatagc gctcagagca agtgctctac ttcaggcaat gagtcgggat attgaggaac 61920

aaagaaaaga attcaatctg acagaatatc atcaaacata tactcgtaat gcggtcgcaa 61980

aattgcctaa gctgagccga cgcatcgtag agctggccgt taaagaaatg gaagaaagcg 62040

gctatgaatt taataaaaag caggttggca acgtcgagca atatgcacta acaattcaga 62100

acgttattga tatatatgct caccgacaga tacctaagta ccgtgatatt cataaagcac 62160

cttacgtaat ttttgtcgtc aacctaaaag gtggggtatc aaaaacagtc agtacagtaa 62220

cgctggcaca tgcattacgt gtacatcagg atttgcttcg ccatgatctt cgtattttgg 62280

ttatagacct cgacccgcag gcatccagca ccatgtttct ggatcacacc cacagcatcg 62340

gcacagtcct tgaaaccgcc gctcaggcaa tgctgaatga tctggatgct gaaacgttgc 62400

gagaagcggt tatacggccg actattattc caggtgttga tgttatacct gcttctattg 62460

atgatggttt cgtggcgagc cagtgggagt ctctggtagc agaacattta cctggtctta 62520

aaccttctga agttctcaga aaaacaatca ttgaccgtat cgctggtgat tatgattttg 62580

tctttattga tactggccct catcttgatc cattccttct gaatggctta gctgcgagtg 62640

atttgctttt gacccctacc cctccggcac aggttgattt ccattcaacc cttaagtatc 62700

tgactcgttt gccagaaatg cttgagcgtc ttgaagaaga aggtgtagag ccacgcctga 62760

gtgcaagtat tggatttatg tcaaaaatga ccagtaagcg cgatcacgaa acgtcccata 62820

gtctggctcg tgaggtgtat gcgagtaaca tcctagactc atcgctcccg aggttggacg 62880

gattcgaacg atgtggtgag tcttttgaca ccatcattag tgctaaccct gtttcgtacc 62940

cgggaagtgc agaggcattg aaaaaggcac gtactgaagc tgaacggttt actaaggccg 63000

tatttgaccg aattgaatat atcaggggag cgtcaaaatg aaacaggtta tagctcgtgg 63060

tcgggttctg ggaaatagta attcagagtt cgctagaatg ctcgaaggcg acggtgatgt 63120

taaaacattt acccttaaat caggcgtgca ggctaggttt gtcaaaacag ttgtgttaag 63180

cggagaagtt gaatcaaaaa cgttcgttga tgcttcggtt aatggacgtg atcagacaat 63240

gcttacgcgc gagtccgtca gtgatatttc ccggacgata aagctgcagc agttctttcc 63300

ggctattggt cgggaggtta atggactaat tgagatatta gatggaaccc gacgtcgtgc 63360

tgcctgcatc tttaataacg ttaaattcga aattctggta acaaaagatg atatctcact 63420

cgccgatgca cggcagttgg cgaaagatat ccagactgcc agagaacata gtcttcgcga 63480

gctggggaag cgactcgaag ttacctacgg aaccagcatg acgaaagaag atattgcgtt 63540

gaaagaaaat ctctctccgg cgaaagtgac acgtgcgttt caggccgcag cagtgccaga 63600

cgaaatggtt gcagtgttcc cggtgataaa tgatatttcg ttgtcagatt atcagttttt 63660

actgaaactg gccgaagaag caaacaacaa gcaaacatcg gtaacagagc tgatggaaaa 63720

agttcagcat cggttgaaga ccatgccaga ttatccggca attgataaaa gcaaaattct 63780

tgcggttatc cggtcggaga gcaaattgct gacagccctc ccaactagaa cggttcaaac 63840

agagaagctg agagaatttt cagatcgtaa tcagtttgcc agaaagaaaa ctgatccaaa 63900

gaagcgactt gttgtttatg agttttcccg tatttccgct gaggcacagt cggagattga 63960

taaggcaata aaacgtattc tggaaagact tccagaatca ggtgagtaag ggataaggat 64020

gccgaagagc atcctttttt gtatgttttt caccacgcca atttcatggt tatttgtttg 64080

attataaagg aaaattgaaa attctttcac actgaaatca ccacgctttt caacctcttc 64140

gtgactcata atttcgctat tggcagttca gaccagcgag ttgtataggc aggcgaaagc 64200

atctcccgtt ttatatgcca ttcagacgct accccttcca gcaaaccaca cttttcccag 64260

acatgaatat ccatgtatct catctgttcc aacttatgta atttactttc tccatttaca 64320

ctgcgttgcc atgcactcgc tttcaggaaa tcagtataat agcccctaaa tcatcttctc 64380

ggagtgaatg gacatggcta ttgcaggttg cgatttacca acttttgcca cccggctcaa 64440

tgaagtgctt actctcagtg tgccagtgcg tacacctgaa aagctttttg ggcgggataa 64500

gcagttggag acgatacaac tggcacttca ttcaccgggc cgacatgtgt tcatttatgg 64560

cgatcgcgga gtaggtaaaa cctccctcgc ccacacagcc gcttcgctta tccagtcttc 64620

ggataaccgt cctattaccg tcagttgtga ccatgactcg accctggaaa cagtcatcga 64680

atcggttatt agccaaggaa tgatgcgcat gccggtagac cggtacaaaa cgtctgcaac 64740

ttttggtctc aatattcctg ttttaaaagc cgaagcccgt gttgaagagc gtgaaacttc 64800

tcgcgttcgt tcagtcgtta atatggccag tgctgttgaa gccctgaact atctgacgga 64860

acgctattcg gataacacgg ttattgttat tgatgaattt gacctgatcc gtagcgagga 64920

gcagcgtgcc cgctttggtg ttttgctcaa gcagttaagc gatggggatg tacccgttcg 64980

tatcatcttc accgggattg ggcagtcggt atctgatttg attggcggac atctgtccag 65040

tcagagacag attgagcagg ttgatcttga acgtctgcac tggacaggtc gtcagcgtat 65100

cgttgaaagt gcatttagat attttgatat taatatccct gatgatatcg cagaccgtat 65160

atgcgcgttg agtgatggat ttccctacta tgtccatctc atgtgcagca agctccttca 65220

tgagtgttac atggcagatg aagtcgttag cacagttaca cgtgatctat ttctagcttc 65280

gctcgatgca gctgtattgt ctgctgagga aacgctcaga tcatgttatg aggcagctac 65340

ctgccgagat gagcatatgc atcacattct ttgggcgatg gctgaaggtg cagacctcaa 65400

cagaatgaaa gaccacatca ttacctccta tatccaggtg atgaagtacc tcgacattga 65460

acctctgacg cagaaaaact tcgacagtcg ttttgctcgg cttcgtaaag agaatcacgg 65520

atctattctg tgccatgcgc ttgtcgggaa ggatggtgtc cggccaggat ggtttcggtt 65580

cagggaaaac atgatcagag gctttgtcag aatgcaggca gagaagtgcg gaatagttct 65640

ggattttgat cggcagtata gcgcccatac agcaagtacc agaacagctg cagttagagg 65700

ggtatacaat cccctcagca cggtggaacg cagcgtagct cgcctcagac gtgatgatga 65760

aaaggaagct gaagaaaacg aataacgtat ttgtaaatga atggaatacc cgcgaattat 65820

atatgcaata ctcgggtatt cagcgtttgc atcatgtcga gttacccgta cagcggagtc 65880

ttgctcttct cctgtctctt gatcaggcaa ttactcaatt ttcgaggcta acatcttaat 65940

gctgttttag tgtcggggga tgctgctaac atcttcttca ggctgtgggg cacgaccagg 66000

cgcattgaac gtgatagtga tgatctttct ggccagcccc tcctctgaaa gggcatcatc 66060

cacactgaca tcacgaatca gtggactttc ctcttctata tgtcgggcaa tatcccgcag 66120

ccactctgcc agcatttctc tgtccatctt tctccgctcc ggttgtgtac attcagcatc 66180

aacataccac accagaaaaa gtgaagtctg cgtagtgtgg ttaaaagatg accgttttgt 66240

caggcgcgct gtcatccgtg ctggtagcga cctgcgcgga ataccctcat tttatacaca 66300

ggattgccca ccgaaattgt ggacagcaac gatgaaaata cgatgtcgct gcgctcctca 66360

ttcatatcgc tctgctgtga acgccgtgcc gctactgtag ccgggccgct gcgaatgcaa 66420

gggttcgctc tgccggtgtc ctcacccggt cgcagtttat ttcaaaggct ttacccgctg 66480

tcttcccgtc gttttccgtc tcaattttcg ccgtcaaacc gtccagccag cgtgggcttt 66540

ttcactgcgc tgcggcttgc ggcaccgccc ctgcattctc cgcttttcgc ccggctgtcg 66600

tatcggcacg gcgtaactgg cgccgcattt gagaaaggag aactaccatg tcccgattta 66660

tccagggtaa ttgcgtccat atcatgtccg gctttccgga taatgctgtc gatttcattc 66720

tcaccgaccc gccatatctc gtcggttttc gtgaccgtca ggggcgtacc atcgccggcg 66780

ataaaaccga tgaatggctg caacccgcct gccatgagat gtatcgcgtg ctgaaaaaag 66840

acgcgctgat ggtgagcttc tacggctgga accgcgtcga tcgctttatg gccgcctgga 66900

aaaatgcggg attcagcgtt gtcggccacc tggtgtttac caaaacctac acatcgaagg 66960

ccgcatatgt gggctatcgc cacgaatgcg cctacatcct tgcaaaaggc cgtccgcccc 67020

tgccgcaaaa cccgttgaat gacgtaattg cgtggaaata ttcaggcaac cggcaccacc 67080

cgaccgaaaa acccgtaacc agcctgcaac cgctgattga gtccttcaca catcccggcg 67140

cgattgtgct cgaccccttt gccggcagtg gctccacctg cgtggccgcc ctccaggctg 67200

gccgtcgtta catcggtatt gaattgcttg agcagtatca ccgggccgga cagcagcgtc 67260

tggccgccgt ccggcgcgcc atgcagtacc cggccgctaa cgacgagttc ccggaggccg 67320

cgtaatgaac tatgcaggac acgaaaaact ccgcgcagaa gtggcggaag tagccaacag 67380

catgtgtgac ctgcgggcga cgctgaacgg gatggagcac cgctatcgct ttgactctga 67440

tgtgctggtc gaacgcctga cccgtcagac cctttttcgc atcaatgccc tgtttatggc 67500

ggcatacaac gaaatgcttg agctggatgc ctgctttaag gactaaggag aaaaacatgt 67560

acggaacctg tgaaaccctc tgccgcttgt tgcgtgagca gtatcccgca gaaaccccgc 67620

tgaacctcat tgtctggtcc ccggcggata tcgaagcact ggccgacgga atggaatatg 67680

ccgtttcgga acaggacaca agggcggtac tggcgcgtat ggacgccata ccggaagaac 67740

aacagcttga gtcgggcgtg tctgccggtg cagtgatgga tctgattgaa caggtgaaag 67800

aggcagttcc ggcggtgatg gtgccggcgg atctgcttga aaccctgcta accactgccg 67860

aacaggcgtt atggcacagg gaatggaccg cccgtgacag caatcatccg gtcccggaaa 67920

gcgttacccg ccgcctggct gatgcggcga aagttcgcgc attactgaaa aaatgaaatc 67980

aacacgccgc ccgggcggcg tgtactgacc ccgttcagag gaacccatta tgcaggaaac 68040

caccacgtta aacgcccttg tgatgcgccg tgcgcgcgat ttgattgctg attatggatg 68100

gcctgaccat accgatgttg atcagcgtga tccggtcaat aaaccgggat ggataagcat 68160

ttatgtccgt ctggatgcgg caaatattgt tcatctgctt cctttacttt gtagcggtga 68220

catacccgca gagctgcaaa atgccatgac aaaaatagcc gggacgtcag cgcagattat 68280

tttatccggc agccgctatg ccgacgcgcc gcagcttccg gaggacggaa cacagatagc 68340

gttcccctgg gccggggaat ggctgacgga gccggagatt caggctgtaa cggattgcct 68400

gtcccgcgcc gtgcgggatg tatcccggca ggtatgggag gatgcgcgcc ggataaaggc 68460

ggcgctgacc acgcgcgggg aaacgctgtt ttatcgtcag acccgaaatt tccgtctggt 68520

tgtgaaggaa aatgatatgc cctgctggct ggacgatgat gacaatttgc cggtggtgct 68580

cgatgccatc ctgaacaaag gggcacgcta cagcagcgtc gagttctttg ttatcagcga 68640

caaagttgat caaatcctgg catgtggcca gatgtgcgat gtgctgcgta ttccgggcga 68700

gcctccgcgc cggtggatgg atttaaccct gttacatgag gtcatggcag aagcgcgtgc 68760

agaaatcagt cttgtccgca atgccctgtc agcaatccgg ccagtgtagc gaacagcagg 68820

gggcggcggc cccctgaatc taccacgaag gatgtcgccg gctccgcttt tacggctctt 68880

cctccacgtt gttccggctt cgcggtgagt aacgtcccga gcggtctgcg gcttacgccg 68940

tgcctctact ctagcccgaa cgctgcaaat gcaagggttc actgacgtcg atgctttcac 69000

ccggtcgccg tatgtttaaa tgcctgtcgc ggttcttccc gtcgttatct cgctcaatat 69060

tcgctcgcta accgtccaga ccctctccgc tatttaccgg cgctgcggct tcatgcatcg 69120

cccctgcatt tttcgctccc tgtcgggctg tcgtgtcggc acggcgtaag ccgtaactca 69180

gacaacatcg actatggagg attttttatg cgcactacga ccaccacacc ggctgtttat 69240

gtgggtacgt atcacaaata caactgcggc agcatttttg gcaaatggtt tgaactgacg 69300

gagtttgacg gcagggagga tttttacgag gcctgccagg cgctgcacgc cgatgaatgg 69360

gacgcagaat ttatgttcca ggaccaggaa ggtatcccgt cgcagttcgt ctctgaaagc 69420

gccattgact gggattttat cgccgcttac aaacgcgccg aagaagaggg cagggaagcc 69480

gcttttatcg cctgggcgga gtataccggc gagtgtgact atgacgcgtt tgatgatgca 69540

taccgcggcg aggcggaaag tgaggaagac tatgcgcagg agatggttga cgataacggc 69600

ctgttaaatg aggtgccgga gccgctgcgc agctacttcg attttgaggc gtatgcccgg 69660

gatttgttca gcagcggcta tgtgttccat gacggttatg tcttcggtaa ctgattttcc 69720

ccggcaggcg gtttagccgc ctgtcagccc gcgcgcaaaa ccctggcagg ctctgcctgc 69780

cggcgaagta cgccgcgcct gcggcgccgc gtatctccgc cagtgcctga tgtcccggtg 69840

gtgtcagggt atgaataccg gtttgttgca gcgggtcggt gttatttctg ttccggtgtt 69900

aatacctgcg ctgccgtagg caatagtggc cataccggtg gcgtactggc tgatatcgct 69960

gtcctgtcgg cttttcttcc cgggcgatat gactgtgggc gacttcccta gcgggaaccg 70020

gcgctgtcgt aaacggagcc ggtaaaccgt ctccgccctg tcgggcttcc atcgcactgt 70080

cgcaggttca acatcacgct tgcggcatcc gtaaacggat gcgccgctct caccagcccg 70140

gcggtaatgc tgccgggctt cttcggggca acgccgtttc gcgcccgcgc gttccgtcgt 70200

tgcagcgggt tcctgctcat tttctcctgg tcatttcacc cttttgagtc ctttcgccgg 70260

ggctgagaca agcacagccg ctgtcagctg tccagggtaa atggcacgcg gtaaaccgcg 70320

ccctggacat ccgccatcgc ccgcgctggt ttacgcccct gcggcgaacg gctctcaaac 70380

gggtgatggt ttttaaaagc aaaacaggtt cagaaggagg agcaacatga gcgaggcgct 70440

ggcggtttta cccgacgaca cctttacccg cgaacaggct gaggtcgttg cggcgcagta 70500

caccaacgtg gcaattgagg acgatcaggg ggcgcatttt cgcctggttg tccgtcagaa 70560

cggtgaaatg gtctggcgca cgtggaactt tgagccgggc ggcacgtact ggctcaaccg 70620

ttatatcgcg gactacggta tccgcaagcc gcagtaagaa agaggtgccc tgccggagcg 70680

cgaactccgc agggccagac aatcatcaat atccagtgag gtatcaacta tgtcagtaac 70740

cgatgttaaa gcaaaagccc ccaaaaaagc gagcagcaaa aaaatcacga aggcgcagga 70800

agaagctctg aaagccgccc ttgaggccgc tgtcatcgag tatgttccgc tgtccagtct 70860

cgctaaatcc ccgctgaacg tgcgcactat cccgtattcc gtggacagcg ttcgcggtct 70920

ggctgactcc atcgaggcgc tcggactgct gcagaacctg attgttcaca ccctcgcgga 70980

cggacaatcc ggcgtggccg caggtggtcg ccgactgact gccctgaatc tgctggcgca 71040

ggaagatcgt cttgcggctg atcataccgt catggtgaag cgagtctcag acgacattgc 71100

ggccctcgcc tcggttgccg agaacgagca gcgcgccgcc atgcatcccg ccgagcaaat 71160

cgcaggtttc cgtacgctgg cagagcaggg caaaactccc gcacagattg gcgacgccct 71220

cggcttcggc tcccgccacg tgcagcgcat gctgaagctg gcaaacctcg ccccgtccct 71280

gatggagaag ctcgcgcagg acgaactgac cgttgagcag tgtcaggcgc tctgtctcga 71340

ggacgatcct gcccgtcagg tcgaggtatt cgaaaacgtg aaggccagct ggtcgaacgc 71400

gcccgcacac ctgattaaac gcgctattac cgaaaccgag atgcgcaccg acaacgccaa 71460

atttcgtttt atcgggcgcg atgcctacga ggcagcaggg ggttacgtcc gtgaagatct 71520

gttcagccag gacgagggcg acggcacggc agacagcgtg ctggttgagc gtctggtgca 71580

ggagaagctg gagcgtatcg cgcaggacat tcagcagcgg gagggctggg catggagtcg 71640

cggacgcgca gcccgcatct ggtaccacgg cgaagacggt aaggagttcg tgcagcctgt 71700

tgaacccgat ccggtgtaca cccctgagca gcagcagcgt cttgatgcgc tgcgggagca 71760

gtacgataca tatgacagcg tttgcgacga gtcagatgcg atcgaagcgg acatcctcgc 71820

cattcaggag gcggcagaag ccagcgcgtg gactgacgac atgaagtcag gcgcgggagt 71880

gatggtcagc ctgtacgaag ggcaggtgta cgtgcagcgc ggtgtgcgcc tgaaagcgga 71940

tatgccggaa gaaaccgtaa ccagcagcgt aacggtgcca ttcacctcac gccagcccga 72000

cgccgcagag gggatcagcg ttccgctgct cactaaaatg acctccgagc gtacgctggc 72060

agtacaggcg gcgctgatgc agcagcccga aaaagcggtg gcgctgatgg tctggcgcat 72120

gtgtacctgc gtcttctcgg gctgtctgac cacgacgcac ccgttccgta tcagtctgac 72180

cgtgtcccac ggcagcctga cggagaacgc cccgtccggt aaggatggcg cagcgtttga 72240

gatgctcatg accgaacggg caaggctgaa agccctgctg ccggaagggt gggagaagga 72300

cttcaccacc ttctttgccc ttgacggcgg ggtgttgatg tcgctgatgg ccttctgcac 72360

ggcctgttcc gtggacgggg tacagacccg cgatatgggg cacacctccc gaagtccact 72420

cgatacggtc gaggcggcaa tcggattcca cctgcgcgac tggtggcagc cgacgaagga 72480

caactatttc ggtagcctga aacatccgca gattgtggcc tccctgaaag aggcggggct 72540

gacgggcgcg gcgggtgacg cggagaagat gaagaagggc gatgcagcag cgcatgcgga 72600

gcactttatg cagcacaccc gctgggttcc ggcatggctg aaaggaccag agccagcggc 72660

tgaatccggt gctgacgacg cggtttccga taccgacagc actgacaacg acaccaccaa 72720

cacggcacac gccgcctgat aacggagagc cgcccttgtg tgaacagggc ggcaattgta 72780

acgaacggtg caatagtgat ccacacccaa cgcctgaaat cagatccagg gggtaatctg 72840

ctctcctgat tcaggagagt ttatggtcac ttttgagaca gttatggaaa ttaaaatcct 72900

gcacaagcag ggaatgagta gccgggcgat tgccagagaa ctggggatct cccgcaatac 72960

cgttaaacgt tatttgcagg caaaatctga gccgccaaaa tatacgccgc gacctgctgt 73020

tgcttcactc ctggatgaat accgggatta tattcgtcaa cgcatcgccg atgctcatcc 73080

ttacaaaatc ccggcaacgg taatcgctcg cgagatcaga gaccagggat atcgtggcgg 73140

aatgaccatt ctcagggcat tcattcgttc tctctcggtt cctcaggagc aggagcctgc 73200

cgttcggttc gaaactgaac ccggacgaca gatgcaggtt gactggggca ctatgcgtaa 73260

tggtcgctca ccgcttcacg tgttcgttgc tgttctcgga tacagccgaa tgctgtacat 73320

cgaattcact gacaatatgc gttatgacac gctggagacc tgccatcgta atgcgttccg 73380

cttctttggt ggtgtgccgc gcgaagtgtt gtatgacaat atgaaaactg tggttctgca 73440

acgtgacgca tatcagaccg gtcagcaccg gttccatcct tcgctgtggc agttcggcaa 73500

ggagatgggc ttctctcccc gactgtgtcg ccccttcagg gcacagacta aaggtaaggt 73560

ggaacggatg gtgcagtaca cccgtaacag tttttacatc ccactaatga ctcgcctgcg 73620

cccgatgggg atcactgtcg atgttgaaac agccaaccgc cacggtctgc gctggctgca 73680

cgatgtcgct aaccaacgaa agcatgaaac aatccaggcc cgtccctgcg atcgctggct 73740

cgaagagcag cagtccatgc tggcactgcc tccggagaaa aaagagtatg acgtgcatct 73800

tgatgaaaat ctggtgaact tcgacaaaca ccccctgcat catccactct ccatctacga 73860

ctcattctgc agaggagtgg cgtgatgatg gaactgcaac atcaacgact gatggcgctc 73920

gccgggcagt tgcaactgga aagccttata agcgcagcgc ctgcgctgtc acaacaggca 73980

gtagaccagg aatggagtta tatggacttc ctggagcatc tgcttcatga agaaaaactg 74040

gcacgtcatc aacgtaaaca ggcgatgtat acccgaatgg cagccttccc ggcggtgaaa 74100

acgttcgaag agtatgactt cacattcgcc accggagcac cgcagaagca actccagtcg 74160

ttacgctcac tcagcttcat agaacgtaat gaaaatatcg tattactggg gccatcaggt 74220

gtggggaaaa cccatctggc aatagcgatg ggctatgaag cagtccgtgc aggtatcaaa 74280

gttcgcttca caacagcagc agatctgtta cttcagttat ctacggcaca acgtcagggc 74340

cgttataaaa cgacgcttca gcgtggagta atggcccccc gcctgctcat cattgatgaa 74400

ataggctatc tgccgttcag tcaggaagaa gcaaagctgt tcttccaggt catcgctaaa 74460

cgttacgaaa agagcgcaat gatcctgaca tccaatctgc cgttcgggca gtgggatcaa 74520

acgttcgccg gtgatgcagc actgacctca gcgatgctgg accgtatctt acaccactca 74580

catgtcgttc aaatcaaagg agaaagctat cgactcagac agaaacgaaa ggccggggtt 74640

atagcagaag ctaatcctga gtaaaacggt ggatcaatat tgggccgttg gtggagatat 74700

aagtggatca cttttcatcc gtcgttgaca gttgcctcaa tgtgcgctga cgggcaggac 74760

gtgtttcgtc gcttcctact gaaagatccg aaagccggtg tcggtatcag tctatgcaac 74820

aaggtgttcg aaaacccaat tccgaagttt gaggtacagc tggcgtctcc gtacaaggag 74880

aaaggcgaca aatacccatt taaaccaaac ccaaaggcca agtggccaat gatcggcagc 74940

ctcaaactcg atggtctccg ggttatctgc gaagtcatcg tggatgagga agaggtgaac 75000

ttcctgacgc gcaccggcaa tccgattacg tcactcgatc accttaaacc ggccatgctg 75060

gagcgtggcc ggctctccgg tttcaagcac atcttcttcg atggtgaggg tactgcaggt 75120

acgttcaacc agtccgtgtc ggcgcttcgc aagaagaacg tgaaagccat tggtgccgtt 75180

taccacatct tcgatttctt cttaccagag tggcgtgctc aggcaaaaag caaagagtac 75240

ctgaagaccg gtatgaagct gaaagagcgc ctggctatgc tggtgtcatt gttccgcaac 75300

acttgcgggg aagattacgc gcaagatatc cacctgcatc cgttctacat catccatagc 75360

catgaagact ttatcgaacg cttcatgaag cgcctggatg agaatgaaga gggggagatg 75420

ggcaaagatc cggattctgt ttacgagttc aagcgtaccc gcagctggtg gaagctgaaa 75480

gacgaggatt ccgaagacgg tgaaatcatc gacttcgagc caggcgaccc ggactctggc 75540

tttgcgcata cgctaggcaa gatagtgatt cgtctggaga acggcgtcat cgttcgtgcc 75600

agcggtatca aacataagta cctggatgag atctggaaca atcaggagaa atatcgtgga 75660

cgcatcgtcg aggttcactg ccatgagaaa acgccagacg gtagcttacg tcaccctcgt 75720

ctgaagtggc cgaaatgtct gcgtgatacc gaagatcgta ttggagataa agactgatgt 75780

tcggctggat gattgtattt ttggttgtcg gcattgttat cggcagtctg gttatgtcca 75840

gctgcatcaa cgattacgta aaagccggtg tcatgcagag gcgcggccgc atttaccgca 75900

ttgtagatat cacgtacaca ctgaaggaga ttaaggatga tcatgttaag taaacgggag 75960

aaggaaaccc tgcgtgaaat cagccagtgg aaggagttct acgctaactg gaagccaaag 76020

acccgcgcca aactggaacg catgaatctt gtcgctaacg tttcgccaaa gggatgcttg 76080

gagaactatc aactcactga aaaaggacac tcactgttgc agcaattgac tgaggctggt 76140

gcgttccaat gattccatac atcacattat cttttgctgg gggcgtggcc ctcggcttca 76200

gtatctgtcg cgatctggtc aggcaggaac tgaaaaccaa aacgcttcgc atcggtaagc 76260

gtctgtatcg ggttgttcac gagacaggag tgcagaaatg agcaatttga cctctttcga 76320

ctggtggctg gcaacctacc ttgtggcggc cggcttcgga tatgcctttt acgttggtca 76380

gttaatcgtg aagctattgc tgatcagatt tgccagccat aaacgcatag atgacggtct 76440

gtggcgcctg ggttctctgc tggagactca ctacggcgaa ctcaaggaga acgaaactat 76500

cactattcaa gcgaagcgtt ttaccgccat catcacgaga acgccggaac agaaggtgag 76560

tttgatcaaa aagatagcaa ctgaacgagt cacagacaaa taagtattta cttacttatc 76620

tattatgtat aagattcatt tgttttcgtt gggacgcgac tgtttgaacg ttaaatataa 76680

ctgcaaacga agatacgtac ctggcagtag cctaagaagc caaacaccag cgaggtcagt 76740

ttccagcctc gtcaccgaaa tgggacacac tgagcgagtg tgattgcaga acgcaggata 76800

gggcatgttg caccacccat gccctattcg atgaagtaac aggatgggcg gttggtttcc 76860

tcattccatt ccatcatccc ggtttcagcc agctgaccgt ccatcctgtt acgtcatttc 76920

cattacttat gtcgtttaat cttgggttaa aagcggcgac gtaacccggc tggctcggtt 76980

agccagcgca caacgttgag gtcactgttt tttcttttaa tcatacaggt gattccacag 77040

aactgtagtg actgatcaat atgttgggtc gaacataaat cggttcagtg gcctcaacgc 77100

tgtgaaatcc aaaataatta actctttggt aatcctaatg ttactgacat ttccggcttc 77160

acaatattat tgtgatatac ctgcatttca ttgtaaaact ccatgtcatc acaataaatc 77220

gggagaaaat aatgacaatc aatagtattg tcatttcgtc tttttatgac ctccacatcg 77280

taaccatccc gcttatttaa attataaata ggcaaagagt tataatatat gttgtacatg 77340

tgatgaacat actgatcata tgtatcattg aagaaaaaat aagcatacag gcctttatct 77400

acctttattt cactatcgct gaaatgctta ttcctatccc aaacaaccgt tcttgcaata 77460

atgtcattcg ttttatcatg aaaggggatt ctgtttgata ctgttatagc tgtatttttc 77520

ttcaacgaat catataactt acccaatcta cattttgaat ctatcccaga gtagaacact 77580

aaatccctaa aattaaagca ttgaccaatt atatttctct ctttaaggta acagattcgt 77640

ggttgaaggt attcacagtt aatttccctt ctacccaaca aacctttaaa ggaccaaaaa 77700

gggatcatcc tatactgccg tggggtataa ccaaatattt tcttaaattc tctggtgaat 77760

gtctgttgcg aatcataaaa aagctttgct gatatctcta ttattgtcag cctggtaagc 77820

cgtaatagtg cagcagctct actagccctt ctaactctaa tatatgttcc aataggcatt 77880

ccgacatatt ccttaaagga aatttgcaaa taccttctgc tgaatcctga atacaaaacc 77940

aaacagtcaa tgttaatgaa tttcgactcg agattctctt ctatatattg aataattgaa 78000

tttacagtca tctgttttag catgaatata acccaaatca aaataatagc attctagata 78060

gtgggccggc gccgggactt agctatttgc gcatacccag caacaccaat cttagctatt 78120

tgtgcacgcg catcaatatc aaaattagct atttgcgcaa caagcaagtg gagtgcgcga 78180

aaagctaaac tttgtgtgca tttttaaata aaattgttct cagtgaggct gtgctacgga 78240

tataaaaatc cccttcattt gttacccacc tttttacgca tatcgtcgat atgaaatgat 78300

ggggaggggg tgggaaggtg ttgtcaccat tccgtaagga ggttaagctc atgattttaa 78360

atagattaag tacgttagga attattactt tcggcatgct tagttttgct gcgaactctg 78420

ctcaaccaga tatcaaattc gcaagcaaag agtatggcgt gactataggt gagagtagga 78480

tcatataccc gttagatgct gctggcgtta tggtctcggt gaaaaacacc caagattatc 78540

cggttctcat tcagtctagg atctacgacg agaataaaga aaaagaatca gaggatcctt 78600

tcgtggtcac tccgccattg tttcgattgg atgctaagca acaaaattct ttgcgtatag 78660

ctcaggctgg aggtgttttc ccgcgagata aagagagcct aaagtggtta tgcgtaaaag 78720

ggattccacc aaaggatgaa gatatatggg ttgatgatgc gacaaataag caaaaattca 78780

atccagacaa agatgtggga gtgttcgtgc aattcgcaat taataattgc attaagcttt 78840

tggttcgacc gaatgaatta aaaggaaccc ctatacagtt tgctgaaaac ttaagctgga 78900

aagttgatgg ggggaagcta attgctgaaa acccctcacc tttctacatg aacataggtg 78960

aattaacatt tggagggaaa agtattcctt ctcactatat tccacctaaa tcgacgtggg 79020

cttttgattt gccaaaagga ctagcgggag cacgtaatgt ttcgtggaga ataattaatg 79080

atcagggagg gttggatcgt ttgtattcca aaaatgtgac tttatgatga tgtttaaagg 79140

ggacgggaat aatgaggtat tcaaagctgt tcctgtgtgc agggttaact ttggcaacat 79200

tgccttgttg gggacgcgca tatacttttg actctactat gcttgatacg aatagtggag 79260

agagtataga tgtatctctt tttaatcaag gacttcaact tccaggtaat tattttgtta 79320

atgtttttgt aaatggtcga aaggtagact ctggaaatat cgacttccgt ctagaaaaac 79380

ataatggaaa agaacttctt tggccatgcc tatcatcctt acaattgaca aagtatggca 79440

ttgatataga taaatatcct gatttaataa aatctggtac agagcaatgt gttgatttat 79500

tagcaatacc acattcagat gtgcagtttt attttaatca gcagaaatta tcgttaattg 79560

tgccaccaca ggcactttta cctagatttg atggcattat gccaatgcaa ttgtgggatg 79620

acggcattcc tgctctgttc atgaattata atacgaacat gcagacaaga aaattcagag 79680

aaggaggcaa gtctctggac tcttattatg ctcagttgca accgggatta aacatagggg 79740

cttggcgctt tcgtagttca acctcatggt ggaaacaaca aggatggcag cgttcgtata 79800

tttatgccga gcgaggattg aatacaatta agagccgttt gacattgggg gaaacctatt 79860

ctgatagcag tatctttgac agtatcccga ttaaggggat aaaaattgct tcagatgaat 79920

cgatggttcc ttattaccaa tggaattttg ctccagttgt tcgcggtatc gcacgtacac 79980

aagccagggt agaggtttta agagatggct acactgtaag taatgagttg gtgccctcgg 80040

gaccatttga gttagcaaat cttcctctgg gtggggggag tggtgagctg aaagtcatca 80100

ttcatgaaag tgatggaaca aagcaagttt ttacagttcc atatgacaca ccagcagtgg 80160

cattacggaa gggctatttc gaatattcaa tgatgggggg agaatatcgt ccagctaatg 80220

atcttacaca aacatcgtat gttggcgctc ttgggatgaa atatggtttg ccaaggaatc 80280

ttacgttata tggtggacta caagggtccc aaaattatca tgccgcagct ctgggtatcg 80340

gtgctatgtt gggtgatttt ggtgccatat ctacagatgt tactcaagca gacagccaga 80400

aaaataaaca aaaaaaagaa agcggccaac gttggcgcgt tcgatataat aagtacttgc 80460

agagtggaac atcgttaaac attgctagcg aggaatacgc cacagaagga tttaacaaac 80520

tcgctgacac gttaaatact tattgtaaac ctaatactag aaacgattgc cgttttgatt 80580

atgctaaacc caaaaacaaa gtgcaattca atttaagtca aagcatacct ggttcgggga 80640

cgcttaattt cagtggctac agaaaaaact attggcgtga cagtaggagc acaacttctt 80700

tttctgtagg ctataaccat ttttttagga atggtatgtc attgacttta aatttatcga 80760

agacacagaa tatcaataag tatggagaaa aaactagtga gctattatct aatatctggt 80820

tgagttttcc tctcagtcgc tggctaggta ataactcaat aaattcaaat taccaaatga 80880

catcagattc tcatggtaac actacccatg aggtaggtgt gtacggtgaa gcctttgatc 80940

gccaattata ctgggacgtt cgcgaacgtt ttaatgaaaa gggcagaaaa tatacctcca 81000

atgcactgaa tttgaattat cgaggaactt atggggagat cagtggtaac tacagctacg 81060

atcaaaccca aagccaactt ggtataggtg taaatggcaa tatggtaata actcagtacg 81120

gtataacggc tggccaaaaa actggagata ctattgcatt agtacaagcc cctgatataa 81180

gcggtgcttc agtgggatac tggccaggca tgaaaacaga ctttaggggg tacaccaatt 81240

atggttactt aaccccttac agagagaata aggtagaaat taacccagtt actttaccca 81300

atgatgcaga gataacaaat aatattgtta gcgtgatccc gacaaaggga gctgtagtat 81360

tagcaaaatt taacgcaagg attggtggac gattgttttt acatttaaaa cgctctgaca 81420

ataaacctgt tccatttggt tctatagtta ccattgaagg gcaatcatcc agctctggca 81480

ttgtcggaga taatagcggt gtctatttga ctggactacc taaaaaatca aaaatacttg 81540

ttaagtgggg gagagataaa aatcaatcat gttcatctaa tgtagttcta ccagaaaaaa 81600

cggatatttc tggtgcttat aggttatcca caacctgcat cttaaataac tgaaacggat 81660

gtttatttca aacaggacac aagccctctc tacgaatttg ttcgtggatt ggattattcg 81720

atagaggtaa tatatgaaaa aaatcagttc cgttatcgcc attgcattat ttggaactat 81780

tgcaactgct aatgcggcag atttaactgc aagcaccact gcaacggcaa ctcttgttga 81840

accagcccgc atcactctta catataagga aggcgctcca attacaatta tggacaatgg 81900

aaacatcgat acagaattac ttgttggtac gcttactctt ggcggctata aaacaggaac 81960

cactagcaca tctgttaact ttacagatgc cgcgggtgat cccatgtact taacatttac 82020

ttctcaggat ggaaataacc accaattcac tacaaaagtg attggcaagg attctagaga 82080

ttttgatatc tctcctaagg taaacggtga gaaccttgtg ggggatgacg tcgtcttggc 82140

tacgggcagc caggatttct ttgttcgctc aattggttcc aaaggcggta aacttgcagc 82200

aggtaaatac actgatgctg taaccgtaac cgtatctaac caataatcca tatagataat 82260

agataaagga gggctattat gccctccttt aatatttatg aattatccta ctttgagcct 82320

aaccctcgct tttcttaatc acggcattga tagcaagact gacaaattta tgtgaagatc 82380

aatgttagga actaatgcag aaagccacgc cctcaataga tttcacataa tacactatta 82440

gctaagaata gagagcgcga agcaatataa taggctcata tttataactc tcaccttaat 82500

atgcacttgc aataccattg agtatattat ctggtgggaa tttttttctc ctaagcgagg 82560

atatggtgtt ccaaaagcga tttcaacata tccgcctaac tgcgggaaga attattgttt 82620

taggtgtggc aattatttta atggaaatct tgttgttagg gattttgttt tttattagcg 82680

aaataatccg aaatttataa tcaccctccc ttttgcgtca tttctttcag gcgccctcac 82740

cctcttgagg agagcaagag gggtatccat catccatgca acttcaacaa agcagccttt 82800

gccctcaccc cggggttttt ttatttggta gcaacccacg tcctgcagcc ctcaaaacct 82860

tcatagccgg taaaaatgat tccataccta ttaagtatgg aatcattgta caaaacaggc 82920

tattttatgg ttgatcatac aaaaacttat gcctaatata ctgttcatgc atacagttaa 82980

aagggcttca ctcagtgagt ggacgatgaa aaacaccttt gataaagcac gcgcagcaga 83040

aaatacctct cgggaagcca tcgagtacct cgaacgcgct tccggtttgt cggcagtgtc 83100

gaccgccaat ttcgacggag acatgtcgtt ttcttccgcc ttcatgttgt tcacccgctt 83160

atccttactg ataacgagac gtcgacctga aattgccgtt cattgtgttt tgatacatgt 83220

gatgccgcat atctctgaag taaaggtaag tgatataagt agggtcttgg tcaaccagct 83280

ggtgaaccca ctgatactgg aaggcaagat cgtccagggc agacgcgtgt tctccctgat 83340

gaaacagttc ctgagctggt gtgcctttca gggattgatt gatacttcac ctttgaatga 83400

tatgtcgctc aacaaagttg ccggtggcgc aaagccagta ccgcgcgaac gtaagctgac 83460

cgacgctgaa gtctgggtat tctggaatat ctgggattat ttcaacgtat gtgaaggtac 83520

aaagtgggcg gcaaggctat gtcttgttgc tgccaggcgt ccagatgaag tgctccgggc 83580

cagaaaggat gagttcaacc ttcaacgtga tgtatggaat caaggtacgc gaaacaaatc 83640

ggccagacag cacgcgctgc cgctaagtcc attaatgcgc aaatgcgtgg aagagttgtt 83700

cgaatacgga aagggcagcc agtggcttgt tccgtcaaat aagaagaagg gcgttgatac 83760

accaatgtcg aaggtggcca ttgcacaagc gttgagaaga attctggagc gcccagagct 83820

gatggatttg gaacctttca caccacgaga cctgagacgt accgctcgta gttattttcc 83880

agccctgggg atcaatcaag aagtggctcg taaaataatg aatcacagtt tggaaggcat 83940

agatcgcgtg tacgaccggc acgactatat ggatgagatg cgagacgcct tggatagatt 84000

ctcagcgtac atcgcatcca tcgtagagca acaagattta gacgaaattg accacaaatt 84060

taagggagat cgtctagcaa ctgagcttat tcgtgtaaat ttctcatagt ttcttgattg 84120

cttcaacaac ctgatctgat gcgccgcgtt gatcaccgaa acggttgcga aacgcttcta 84180

atactctttt ttcgtctgcg gaaaggggag ccgttccttc ttcgcggaag aactcaagca 84240

actccgggtg acgctcttcc aggaccatca gcattagccg aacagggtca gcgtccagag 84300

ctacggccag cgctcttacc ttatcaacgg ggagagggat ctttccgctt ttgatgagag 84360

acaggttgtt ggcgttttta taccctactt ccttggcaat agtagcctga cttttcggtg 84420

agatagtgat cagggaatca atataagccg cgtagcgacc ttgtttgcta tctgtttcgt 84480

tggtagccat gtaataacct tgcgtgttta atttgtctct ggtaagtgct tactgatatt 84540

acattaaagg tgagggttgt aaagacttat ctatttcttt cgataggcat caaaaccctt 84600

tacctatgcg cattatacat ctattaagcg gcaaattgtc attatcagct tgcatggttt 84660

gtcagacaaa tctgatatag atgtattccg tattgataca ataggtagta gtatttccga 84720

actttcgaac gtgttgagtt ggatgatatg agatgaaaaa tataacttct aatttgaacg 84780

cccttgaggt tggacatgca tatgcgctcg ggatggatgg cgtggcaacg atacttacag 84840

aacttaatac tgaagaactt ccgatagaca tgagcgacac gactgtcttc actttcgaac 84900

tcagcaacaa acatttcact ctcatcaata ctggctgcgg ctcacttgcc gtaagaaccc 84960

attaactgca aatcctacct attgaaacct gtacgaacag cttggccacc tgttcgtaca 85020

gcataaaatt acacacatta gaaaacaaat tgttttaata acaaggaaat tctcatgtcc 85080

aaagccatga ccagagctgt gctgaaagag gtacaggact tccgcgactg cgtaaaacga 85140

gttgtagcga tgctttcagg caaacagata cctgttgcag aacgaggcaa tgaagcgtat 85200

gtccgctaca accggcgcgg cgaaccagtg ctggtaaaca tcccatctat accggacgac 85260

gcatcaccaa ccctcatgaa cgcagtacgt ggttttctcg accatgaagt agcccatatc 85320

ctctttactg atccgaaagt cgcgatgaag atgcgcgaga gaggaaaggc tccgtctacc 85380

gggctttgga acgcgctgga agacgttttt attgaacgca gaatgggaca ggtattcaac 85440

ggaacccgtc gtaatttgct agccacacag aacctggtga tcgacaaata cttcaagggc 85500

aaagtgtcag aggcggtttc aatctgccac ggcaaccagc gtgaattgtt cctgaaattc 85560

ttcctttgcc cggtcgtccg cgcctgggat ggccaaagcc ctttcatcga ctttatggaa 85620

gaacactggc acctcatcga taagcctgta gccttgctca aagagcatgg tatcgacgtg 85680

gccgttcgca atatgtcgaa cacagaggac tgcgtaaagg tcgcagctgc tatcgcccaa 85740

atcatgcagg atatgaaaga caagccagag ggcaaattac ctgagcttaa atcatctgcc 85800

aaaaagccgt ctaagagcaa agacgagtcc gaggaaacac cagagtcagg cgacgatccg 85860

tctcatagtg aatctgcacc aaagcgaacc aaaggcgaag acgacgacaa ggaagagcaa 85920

gaagatgatg cctcagaaga ggaagattct ggggattctg atttgcctga ttcattagat 85980

aaggacttac ctatacatga taaagaaatt agtgatacag aaagtaaata tacagaagca 86040

ggcgaagatg agtcaggaga caccccagaa tccgatgatg ccggcatgga atcaggtgat 86100

tctgacgacg aaggtggtag tgatggcact ggcgctccaa cgcctggtga tggcattcgc 86160

gaagacgccg atgactccga tggttatggc tctggcgccg ctggcgatgg ggatagtgat 86220

aacggcgaag actccgatgc cggtcgtgag gagtccgaag gagaagacga aggcgaagag 86280

gacgtcgccg atcacactga cggcgaaggc aaggaaaatg aggatgccgc ggaagcgcct 86340

gaagacagtg agtcaggctt tgttcctgcg ccggatgaaa tgactctgga ggacgcactc 86400

aaggcgctcg acgagatgga agaaggaaca gacgaaatga ccgaagacgc actgtcggcc 86460

accatcagca aagagcttat gagcgcctca ctttctgagt atcgcccata cgatcgttca 86520

tacgacttta tcgggttgat tgatgaggct gaagagcatg taaaacgcac cagaaagaca 86580

ttcggcgcaa tcccaatgca ctcacctgtc gatcgctacc gcatggttcc ggaaggcaga 86640

aaactctttg aactgaaaat cgaaaaacat ctgtctgccg gcgtttcttc gactctggcc 86700

aaagacctgg agcgagctat cgccagccgc aaccgagttc agttcatacc gggtcagaga 86760

cgtgggcgga tacatggcgc gaacctgtat cgtctggcaa tgaacgacga ccgcgtgttc 86820

cgcaagaaag aagaccacag agcggtgaac gcgtgcgtcc agcaggtgat cgacttgtcc 86880

ggctcaatgg gcggcaggaa gattcaactg gcactcgcca gcgcctacac cattgcggat 86940

gctctggatc gtatcaatgt gcctaacatc atcaccggct ttacaacgtt tggtagccca 87000

gattatgaaa ccatgtcgaa gcgcgggttt acacgtttcg aggcgctcat gctgcccatt 87060

atcaaaaact ggaatgagaa agctaactca ccagagatcc gcgcccgcat gggctgcgta 87120

tgtgagacgt tccccctgct caataacgtc gatggtgaga gcgtcgcgca gctggccact 87180

ctgtttgcag ggcgaatgga ggacaaaaaa atcatgctgg ttatgagcga cggggcacca 87240

tgtgctgcag gcgatgggtt ccatgagcat ttgcgaaccg tcaccaaaga aattgagacg 87300

ttaagtgaca tcgatttgat ggctatcggt gttctgactg acgcaccacg acgctactac 87360

aaaaattacg cactggttaa cagcgtagaa gagttagggc cgtcagtcgt cactgagcta 87420

tctcgtatca ttcttgggta agaacttcac ccttaaaaaa taagtaatta cttactatac 87480

agtctaatat atttatataa gatatacccc acgaacgaca aacagtaagg aaaaacacat 87540

gaccgctact gcactacagc aagaagaaca tttgccggaa gccatcgtct gcaagtggtg 87600

tggcaaatct tttcattacc tgaaatccca tatctctatg ggccgttgcg agaacattcc 87660

tgagtccgcg aagggtctgg acgtggacga agtggtgaaa atgtacacct ctgcgtttcc 87720

agatgaacca acgatctctc gcacggcact ggtcaaactc aatgagaagc gtgccgaaag 87780

acattcagga gaaggaaaag tagcggagat tagcgcacat ccgggctacg caggaacggt 87840

cgaatacaag accgaactgg tggccgcgca cgagctgctt ggcgtaacga tcaaagagct 87900

gggaacgcca cgcggaaaac cactacaggt gacggttaac gtcaacacac cctatccgga 87960

gttcgtgcct gaagcgaaga agaactatgt gtatggcgac tttgacctga ttaaagacat 88020

cttcatgatg ctggaaatcg gaatcccagg ctatctctgg ggtcatgcag gaaccggtaa 88080

atcttctctt cctacgcagc tatgcgccct gctgaatcga ccactgatcc gcgcccagca 88140

tacggcgtct atggaagaag cacacgttac aggccagatc ctcgctcgcg atggctccac 88200

ctacttcgag ccgggtttgc tggcgctggc gatgaaaaat ggctgggtgt acctagctga 88260

tgaatatgac ttcgcgttcc cgcagattct gggtgtgtac cagccagttc ttgaaggaga 88320

accgctgatc atcaaagagg caactccgga ctggcgccgt atcactccgc ataaacgctt 88380

tgccttcatt ggcactggca acactaacgg ctctggcgac gaaacgggtc tctatcaagg 88440

tacgaacatc cagaacgcgg cgaacttctc gcgcttcggc attgtttcga acgtgaagta 88500

catgagcact aaggctgaag tcaacatgct ggctgaggct ggcgtcatcc gcgaatacgc 88560

cgagaagatg gtgaaattcg cgaaccttgt ccgtgaaggt tatgagcagc atctgatcag 88620

ccagccaatc ggtcctcgcg agctgctgct atccgcaaaa atcggaatga tgcgcggtga 88680

tttctctgcc ggcatcgaaa agtcatttat caataaactt ccatccacgt ctgcacaggc 88740

agcgcgtgaa gtggttcaga agatcttcgg ttaatcgtgc gtaaaggatg tttcggctct 88800

cttatcgcag cgtctgaaac tggccgggct tgtctggcgt gtccggatag gtccgagtgc 88860

caccagtcag ccaaagaggt tgcgatttcg atgtatggga agttcgttgg cttccccaat 88920

gacaaaatca agaaaaccag aaaggtaaaa acacatgaag gctctgatgg tcagaactga 88980

cttctccctg ggagagtcag ctctaaaagc agaaaacgcg gtgaaaatcg cgagagacgc 89040

tggctacact gctgtcattt ccgctgacag catgaacatt gccagtgtga ttcccctgca 89100

gcgtgccgct ggcgacgata tggcggttat ttgtggtgtt aagctgaatg tggtcgacga 89160

tccgacatac gagcaccgcg cccgccttgc gaaagaatca gagagatgta tggaatcatt 89220

ggtgcgtgat cgcagctact gcttcacggc actgataaag aatgagcaag gttatcgcga 89280

cgtgtgcgaa ctgatgacct tagcgaacaa gcgcgagcaa ttctactttg tcccgcgtct 89340

ggcgctcgac caactggcgg ccgcgtatgc caaaggcaac atcatcctgc tgacgtccga 89400

cattggcagt gtattccagc gccgggactt cgcaaagatt atcgggacgc tggtcacagc 89460

tggaggacgc gataacttct acagcgtggt ttatccgcac cctaccccat tctacgacca 89520

gattaacgtc cgggcgatga aagtagcgag cgcactgaaa atagagccag tggcgttcta 89580

tcccgcttat tacgaagcgg tcgacgacgc tgacattaaa gacattgcgc acatggttac 89640

gaacaacatc aaaatcgacc agccgcatcg tctgcgtatt ccccaccagc gagataacgc 89700

cgttaatggt cgccgccatc tccttgaagc gctgaaagcc ttctccgttc gcatggatgt 89760

accggtaaca gctgcaatgg cctcaacaac gcaggacacc attatcgaag cctgcacatg 89820

gcgctggcat gaattgccac cagcactgcc caagatggca gacgacgagc ctgcaacgct 89880

gatgaagctg gctgtcgcgg ggctgcgcaa gcgtcttact accaaagagt ttggctacac 89940

accaccggct tctgagcacc gcgtgtatgt tgatcgtctg aagtacgaaa tggacacgct 90000

gacccgtctg ggcttctgtg gctacttcct gatggtgcgc gacctgatga atcacagccg 90060

tgaaactggc attcctgtcg ggccaggtcg tggttcctct gccggttctc tggtggcgtg 90120

gtgcatcggc ataaccaacg tcgatcctat ccgtcacggt cttctgtttg agcgtttcat 90180

caaccctgaa cgtctcgact taccggatgc ggatctggac ttcagccagg cacgtcgcca 90240

tgaggtgatc gagtatctga atgaacgcta tggcgaagat tacgttgccg gtattccgaa 90300

cttcacctat ctgggcgcgg cttctgcgct gcgtgacacc gcacgtattt acggtgtcga 90360

tgctgcggat atggcggtat ccaaagagtt caagaatctg gaggacgata gcctgtcgct 90420

ggaagagctg cgcgagcaac tggccagcct ggacaaatac gccacgaaat acccggaagc 90480

gttcaaagcg gcgtgtaagc tgcaaagcct gatgcgtggt tttggtcgcc acgctgcggg 90540

gatgatcgtc gctggcgttc cactggtaga gcgcacgccc gtcgagctgc gtggcaatgc 90600

tcgctgtatt gcattcgata aacgttactg cgaggcgatg gggctgatta agctggacgt 90660

tctcggtctg gcaacgctcg atctgttgga tagcgcgaaa cgctacatca aagagagtac 90720

cggggaagac atcaatctcg atgctatccc actggacgat cgtaaggttc tggatgggtt 90780

cgctgcaggg tacacgcagg gcgtattcca gctggagtcc ggtcccatgc gcaagctgct 90840

taaagatctg ggcggtggca tcgagccaat gagcttcaaa accgttgtcg ccacgaccgc 90900

actcttccga cctggcccga ttcaatccgg catgttggac gactatgtct ccgtggccaa 90960

aggcttcatg gctccacagt cgctgcaccc ggtactggac gagcttaccg cggaaaccaa 91020

cggcgtgatt ctgtatcagg aacagacgat gaacgcgaca cgattgctgg ccggtttcac 91080

gatggccgaa gcagatggtg tacgtaaagc gatcggtaaa aaggatatgg aaaagatgaa 91140

gagcatgggc gagaagttcg tcgttcaggc tcaagctggt tggatcgacg ttgagatgga 91200

agacggcacc acgcagcgta ttcaccgcgc ggaacacttc aaatgtgagg acggcgcact 91260

gcggacggtc gaagaagcgc tggaggcagg tgtgaaattg ccgatggctg ctgtacgcgt 91320

tacagggtca caaccgggct tgtctgagac gaaagctaag gagatctggg atgccttcga 91380

gaagaacggt gcgtatcagt tcaacaaatc acatcccgtt gcctactcgc tgatcagcta 91440

tcagtctatg tggttaaaga cacattaccc tgctgagttt ttcgctgctg cgctcaccat 91500

tctgggcgag gataagcacc aggggctggt taaggatgcg ctgacctatg gcattcacgt 91560

attgccacca gacgttaacg tgtcatctaa ccgaattgag atccgcacgc tggaagacgg 91620

cagccaggtt ctgtatgcgc cattctctgc tgtaaaaggc tgctctgaga atggttgcca 91680

ggccatcatg agagcgcgtg agaaagttgg cggcaaattc gagtcacttg agcaatttga 91740

ggaagcggtc gagaagcgtg cgtgtgcgtg taacagccgg gtacgcgagt cactgcaaaa 91800

agtaggtgcg ttcgcatcga ttgagcctgg cagtctgcca gcgacagatc cggaacggct 91860

gcgcgaccag gctgaattga tgggcaatct ggtgatcgac gctgtaaaag cctctcgacc 91920

gttcgagatg aaccctaaac gctctgccga agtgaatgta ctgatgacac gcatggcggc 91980

tgaaatgggt ctgggagacg acctgatacg cccaagcatt ggcattaagc cgaaaatcat 92040

ggtcattctg gacaacgcga acggcaatga tgggcgtact ggctacttca tggagaacgg 92100

ctacgacgac tttaaggcga agttgcttac tgcaggcgat ttgcgcatgg gagatctcta 92160

cgtcaccggc gtgtgcaaaa aggtgaagga caaagagaag gactacacca aagacgagat 92220

aggccagttc accgacttta tgcgtgaaga gatcaatctg gtgcgtccga cctatgtgct 92280

gacgtgtggc agccgggcga cgtcactctt caacaacaag agcaaaccat ccgacctggt 92340

tggacgcaaa gagtatctgc cagagctgga tgtgaccgtt ttctacggat ttaacccgaa 92400

cattttgtac tttcgcccag aggaaggcga aaagctggaa gcaattctgg cagaggtagc 92460

ggagacaatt agcaaatgaa taaagagaac accatgaacg aagcacagaa gattgcacaa 92520

gcgctggcgg ctatcccagc ggattttcag gataaagcag ttgcagccac catgcggtcg 92580

cagttctggg aaatcatcga ctgcccggtc acgttagatc tggcgctggc gttcgccggg 92640

ctggatggtg ccgataaagt cagtcgtctg cgtaaatgtg ccagagcgct ggcgcttaaa 92700

acgcaagatc cgaaggcgtg ccagtatctg ctggagattt acgaatcgga taacccagag 92760

gaacagctgg aggcgttcaa agtgttccgc aatcggctgg tgctgaaggt ggccaaagag 92820

tttatggaag tgaacaagat tggcgatgtg agacagtaca ggctgaaacg ccagaccaga 92880

gtcacgctat ccaacatttt tggtaagaaa gtcgcataaa gcaaaaaccc gccaatcggc 92940

gggttttttc atgcgcattc ggcgtgatga cgtcgacgtg cgataagtga agaagcgata 93000

tgttcaatct caacaaagtc ttttgagacg ctattgcgaa gggccaaatt ccacttactt 93060

aatacgcgag cattgtgtgc cagctctgcg ttttctttaa ggcgtccatt ggcttcaagc 93120

cagttcgcca catcagccca atcccatagc ggggactgtc cctggattct ctggataggg 93180

caagggaagt cgccaccacc acgaagccca tctttaagca tggtaattgc ttgtcgggac 93240

atgcccgtca tttcagctac atcgctcagg ccaactaagg ccgagtcgac tgattctaca 93300

atcgcgccga taccggcaga ttcgatattg tcgaccgctg atgcaatggc tgcatccagc 93360

gatttggctt cgcggtcgaa ctcaacatag acggagtttc catatgcgca aacaatcgca 93420

tcgccacagc cgctttcgta cagcgcatct tccaatcctt cggtctcata ggttacgcct 93480

gagagagtca gagtgaagtt ataaagcgcc ataaaacctc tttatctaaa gtgaagtatt 93540

aatgtacctt tggaacaaat ggcggccaaa accgccacta actactattt tttgctcatc 93600

tggtttttga tgcgaccaca ctggtcgacc gcttgcctga tttgcgtggc atggtgctcc 93660

ggtacatctg gagtcgacca tacacttctg tggtgacttg tatgttcacc tgatttatcg 93720

ccgcagcgca gcttgcagaa gcaatgtgct gacttacctg ctggaaccca aacccagcct 93780

ttactcaacg cgtattcaat ggcctcttga atatgcttat tcggatgtga tttcattttc 93840

ctccgatgtc attatgatag gtatagtgtg agcgcgtgtc aacactgtct attttctgac 93900

gtctacggcc gcagaaaacg gctatagatt atcagaacac tccctgtttt catcaactta 93960

ccgaccccac cccctaactt cttccttcta taagctccat ccttcatttc tttcatggta 94020

aaattgatat atagaaataa gctggaacat atcaaaatga gtgcagatat ctacgaaaaa 94080

atcatgtccg atctggagtt cgaccgcgac aatcttgagg aagtctggcg tcagcaaccg 94140

cgcctgttga tggagtacgg ctctaagctg gcgcgggcag aacgcgaggt cgcagatgca 94200

aaactctccc tcgatgcgat tgaggcaaaa atctactaca atgagcgtaa gaacctgagt 94260

atgaacggca ttaagttcaa tgaatccgta ctggaggcga aggttagaac caacccgcaa 94320

tacctcgcaa agcgccagaa actcgatgat gcccggcaca ttgcagatct atacaagcac 94380

gctgtaaccg ccttctctca ccgccgtgac atgattgtcc aggcgtccaa aatggctatc 94440

gtggagattg aacgcttggg cgccgaacgt ttccactcgc cccgttaatt tatcctagat 94500

gataagtaag tactgatcta ttatccttct cgctcgaaag agccacgaat aaacgaatgc 94560

ccaacgcgca tagcgccaat ggccacaatc acaaaaagga gaaatacatg tctaagtcat 94620

tacttgatct gcttaacaag acccgtggcg atattgcttc taaacgtggc aataacgttg 94680

atttgacccg tctgaaagac ggcaataact atctgcgcat ttttccgaac aaggacgacc 94740

cgaatggtgt gttcttccag actttcggta tgcactacgt taagcatcag aatgaggaag 94800

gcaaagatgt aaccaccgcc tacatctgcg aacagcacac ccacggccac gcttgccagc 94860

tgtgtgagat ggttatggaa ggtcgtgctc gctttaaggg caacaaagcg atggaagagc 94920

gcattaacag tatgcgtgct acaccgcgtt atctggtcaa tggtgttctg tctgcgcgag 94980

aagactttgc agacgcagag aaatgccagt tgattgagct gccgtctacg gtcttcgacg 95040

atatctgcaa agtgatgtcc gaagatattg ctgatgatat cggcaaccca ctgagcaaag 95100

aagaaggcta tgcgttcctg attaagcgta ccggttccgg tcgtgacacc aagtatgacg 95160

tatccccgaa acgtaaagtc tacaaaggcg acattcctga gaagctctgg actacccaac 95220

acgatctgat cgcatacgcg aaccaggctg acgaaacccg tctgctgtct acggctcgca 95280

ctatgggtcg tctgattggt attgcggctc cggcagcaac aatgtcctct ccggccattt 95340

cttccgctgc aaaatcagct gctgctgaac tgccaggctt tggctctatc actggtcata 95400

cggaaggcgc agctgctgtc gctacagcac acacaccggc tccagagtcc accagcctgg 95460

ttgatgaaga gatcctgcgt gccgctgaag ctgagttcaa accggaaact aaaccggaaa 95520

aggttaaagc tccggaagcc gccgcagctg caagtgcttc cgcatctgct gccgctgcat 95580

ctgtaccagc tgacgaaggt ctcgatgacc tgctggctga actggacgct ctgtaatccc 95640

ataacgtgac cagtaaggcg tctacggacg ccttactttt tggaaggagt gtaccggtga 95700

attatctctt tgtggacggt aacagcctgg gctattacca ccagcaatcc gacaaattac 95760

acaacggcga gatggaagtt caggcggctt ttggcttcgt gaagaacgtt cgtcgttacg 95820

cctcaattct ccatgcccgc ccaatgatct tgtgggatgg attcagcgac aaacgtcgcg 95880

acttctaccc ggagtacaaa gcgaatcgcg atgacgaccc ggatatgaag aagatgaaag 95940

aaggttttgc catccagaag ccgtacatct tgaaaatgat gaccgcgctg ggcgttaacc 96000

aactcattgc aaaggatgca gaagcggacg acctggcagg aatgctggtc tctcgcctgg 96060

ctccgcagcc gaccgttgat catatctacc tgctgactgg cgatggcgac tggcttcagc 96120

tggttcgcga gaatgtgagc tgggtaagcc tgcgtgaaga tgccaagcac aagcaggtga 96180

acttcgaaca gttcgcagag ctgaccggtc tgccgacgcc acgcgcgttt ctggaagcga 96240

aagcgttgca gggcgatacc tcggacaaca tcaaaggcgt aggtggcatt ggtgatggtg 96300

gcgcgaaaga gctgcttcat gaatggggaa gtgtggccgc aatggtacgc ggcattaacg 96360

acggctccat tgtcatcaac aaaggtcgct ataagacggc attcaacaag ctggcaaaga 96420

acgccttcaa cgagaagaca ggctgccgga tgctcgaagc ctttaagcgc aacatgatgc 96480

tgatgaacct tatcgacaca aaattcccac ccagcgaaat cgagtcgatt aaaggcgcac 96540

gcgacatgaa cgccttcgaa cagatgtgtt gcgagctgaa tttccggtcg tttctggaag 96600

atctggaagt gtttgttctg ccatttgaga ggtactgctg atgctgaaat ccatcattaa 96660

tggcggggca actacgccaa ccatgctggc taaagagatt gtcttctgcc acggcgaaca 96720

cgctgtggtg gcgctgccga acattctggg cgctgctggc atttctgcta ctgagcgtga 96780

gttcgcgctg gtcagcgagc aggtcgtgaa gatcatcgct cgcgtcgcca aacacctgaa 96840

ccacgacgca atcaagtttg acgaagccgc agcttcgaag cgaatcaacg aatcaaaagg 96900

agcctaatca tggcaaaagg caaatccgca ctggcactgg cgctgaaaaa gaaaatcggc 96960

agcaatgacg agattcagaa ggtctcccac tggattgact ccggtttccc tccactgaac 97020

aaagccattt ccggacgtta cgacggtggt tttccgtgtg ggcgtatcgt tgaagtcttc 97080

gggccaccaa gcgccggtaa aacctttttg gcgacggctg cgatggtatc agcacagaaa 97140

caggatggtc tggccgtatt ccttgaccac gaaaacagct tcgacgttgg tcttgcggtg 97200

gcgaatggct tgaacgccga cgaagacgac ggtcagtggg tctacaaaca gccggatacc 97260

ttcgaagact ccgttgagct gatcggcaca atcctcaagc tggtgcgcga cgaagagctt 97320

atcccggaaa cagcccctat ctgcatcgtt gccgactctc tggcgtcgat ggtaccgaac 97380

tcgaaagctg agaagttcga caagatggca gaaggcactg cgaaggacaa agatcagctg 97440

aacatgaacg acaacacggc gctggcgcgc gcgacgagtg cgaacttccc tactctggcg 97500

ctttgggcgc gtaagtacaa cgcgtgcatt atcttcttaa accaggtgcg taccaaaatt 97560

ggcgtgatgt ttggcgatcc gactacgtct ccgggcggcg actctccgaa gttctacgcg 97620

tcggtgcgca tccgtctggg agcatccgtc atgaaggatg gcaaagagaa gatcggacag 97680

gacgttggcg ccgagtgcat taaaaacaaa gtcgcgcctc cgtttggtaa atgctcatgg 97740

aaattctact tcgacccgac tcgcgggctg gacgtcatcg aatctctggt tgagtacatg 97800

ctggaagaag gatacctgcc aaagaacgcc agcgggcgtg tggaaattag cgataagaga 97860

tataccaaat cgcagatcgt cgagatgtac cgcgagaagc cactcccgga aatcatcgca 97920

gcactccagg cgatagacga acggcgagcg aaagagtcgt ccccagcaga gacagaagaa 97980

gcgtaatcac aaggcgccca ttgggcgcct ttttatactt gaaaatatat aagtacttac 98040

ttattatttc tgcaccaaaa cgacaaaagg aaacacatga ttaagggtta tctcatggct 98100

gtttcagcgg tggtgtcagt ctgctttatc tacggtttac tggttccatc gcttatctca 98160

gctaaaagcg atctggcctt ctttatcgga cttgccatcg ctgtagtctt cccggttgcc 98220

ttgttaaaag ctggccgcag gtatatcaac tcactcaata aaactaagga gaagtaagta 98280

atgaagaaag gtttactggc ggtgactttg gctgctattt gcacaatggg tctgaccggc 98340

tgcgatcgcg tggaaccggg atacgttggc attaaggtaa acaaattggg tgaagacaaa 98400

ggtatcggtg aagttgtcgg cgttggccgt cagtggactg gtctgaatac cgagctgtac 98460

accttcccca ctttcaaaca gatgaaaacc tacgatgagc cgttcacatt ccagatgagc 98520

gacggtacag ccatcggcca caaaattggt gtggcatatc tggttaatcg caacaaagta 98580

actaccgtat tccagaccta tcgcaaaggt gttgacgaca ttaccgacac tgatctgcgc 98640

cagaagattg cggattcact gaaccgtctg gccagccgca tgactaccga cacgttcatc 98700

gacggtggca aggcgtctct gctcgacaat gcgttgaaag acattcaggc agaaatgtca 98760

ccggtaggta ttgaggttat tagcctgtca tgggtgggca aaccagacta cccggacacg 98820

gtcatcgaat ctatcaatgc caaagtgacc gcgaaccaga aaacgctcca gcgccagcag 98880

gaagttgagc agcgcaaggc agaagcgaac atgctgcgtg aacaagccga aggtgaagcc 98940

gacgctatcc gcaaacgtgc tcaagcagaa gctgacgcca tcaagttgcg cggtgaagca 99000

ttacgtcaga acccgaacgt catggagctg gaagccatca acaaatggaa tggccagttg 99060

cctcagtaca tgactgaagg ggctaatact ccgtttatcg cgttgaagta acaccctttt 99120

caaagatacg gcgtccactt ggacgccttt tttatttccg tattatcacc aacaagaaaa 99180

caaattggtt actaatacgg aattaacttc cgttgaagta aaaagtgaca acgccacgca 99240

atttctgaaa gaaggagatg atgaatgaaa aactacgctg aaatgacgga ctttgagatt 99300

aactgcctgg tcgcggaagc aaccggccat cgccccctca tctcacaata tggctggaaa 99360

ggctcacaag ttggagatta cacaaaagtg attgcgattg ggccaaacgg agcgggttct 99420

ttcgactggt gcaacaatcc ggtagatgcc tgggacatca tttccagaaa cagaatcggc 99480

atcattccag ccagacaggc tggcgagtgg agagcggccc acaggctggt ggatagctca 99540

acaccacaac atctgatcca gaaccctaac cctttcagag cggcaatgat cgtgtttctt 99600

ttgatgcagg agaaaaaacg tgaaaaaact gtatgacgcg gccaacgctg cgctggatgt 99660

agtggatacc gaaattgccc agggcttccc ggagccagaa tgggcgacgc agctgcgtga 99720

ggcgattgca gagatgaacg caccggaacc ttcagaagat gaagccgact ggcagcgttt 99780

catcagaatg tacgcggaag agattggccc gacgccaacc gctgaacagg ccatgctgct 99840

caagtacttc aaggaggctg gggagaatct gccggttgat gacacaccgc actggtttca 99900

cgccgcctgg cgtaagttcg acgtgatcta cacccgcgat ctgggaagta aagatatggt 99960

cgtctggcat ctgatgcaca ttgataaggc tgtcgaccgc acgctggaga agttctttcc 100020

accagcctga acacaatgat tgtgtaccgc atggcgcaca ttagtataaa taagtactta 100080

ccaacaagga gaagcacatg aagattttgg ttcgcatttc atcaagcacc gactatgacg 100140

tttatccgtt gttcatggtc aagtgcgacg gtctgaacga tgaagaaatc caagcggcaa 100200

ttgagcgcaa tctcgttgag tatactggta tggatgcgga ttctgtgcat gtcgatgatg 100260

acggtgtttg ttggagcaat ggtagttgtt ggtatgtaga cgacacgacg ccggtaagcg 100320

atgaagacgc tgctcacctt gagcgtattt taggcatcag cacttttgag tgatatttac 100380

agcaaataat atataagtta gtatttacct atcatgaaaa ccgtattaga caccttatta 100440

cttattatct cgatagcttt tgtgctcgat tgcatcttca ccggagtaat ccataaagcg 100500

ctggcgcctg ttaatagcgc gatgattaat gcgctggccg tagtgctgtt attcgactca 100560

gcattcggcg ttatccaagg agtcgtggca tgaagaaaac agccctggct ctggcactgt 100620

tcactctccc tgtctacgcg aacacacatg tctatgagtg tgaaatgtct gtggccgaag 100680

tgaaaaacga cgagatctgc aacgtcgtca aagctaacta cggcgcgatg attgtggaca 100740

gcggcgaaca gttttatgtc gtgcgcgatg atcgcgtcct gtcttcaccc tatctcacca 100800

gacgtaacgg caaactgtct ggcgtgggtg aagataagtt cgtttacgac aaatcaggtg 100860

atgtttacgg cgttcacgcg aagaacgcca gctacctttt cgatgactgc aaggaggttg 100920

gttgatggcg gttacaatgg caggtcttga aatcgaaaaa acaagcggct actggcgtgc 100980

caaagggttt 100990

3

9960

Yersinia pestis

3

tggcgtgatg atggaactgc aacatcaacg actgatggcg ctcgccgggc agttgcaact 60

ggaaagcctt ataagcgcag cgcctgcgct gtcacaacag gcagtagacc aggaatggag 120

ttatatggac ttcctggagc atctgcttca tgaagaaaaa ctggcacgtc atcaacgtaa 180

acaggcgatg tatacccgaa tggcagcctt cccggcggtg aaaacgttcg aagagtatga 240

cttcacattc gccaccggag caccgcagaa gcaactccag tcgttacgct cactcagctt 300

catagaacgt aatgaaaata tcgtattact ggggccatca ggtgtgggga aaacccatct 360

ggcaatagcg atgggctatg aagcagtccg tgcaggtatc aaagttcgct tcacaacagc 420

agcagatctg ttacttcagt tatctacggc acaacgtcag ggccgttata aaacgacgct 480

tcagcgtgga gtaatggccc cccgcctgct catcattgat gaaataggct atctgccgtt 540

cagtcaggaa gaagcaaagc tgttcttcca ggtcatcgct aaacgttacg aaaagagcgc 600

aatgatcctg acatccaatc tgccgttcgg gcagtgggat caaacgttcg ccggtgatgc 660

agcactgacc tcagcgatgc tggaccgtat cttacaccac tcacatgtcg ttcaaatcaa 720

aggagaaagc tatcgactca gacagaaacg aaaggccggg gttatagcag aagctaatcc 780

tgagtaaaac ggtggatcaa tattgggccg ttggtggaga tataagtgga tcacttttca 840

tccgtcgttg acaccctgat gaattcacgt gttcacgcct gaataacaag aatgccggag 900

atacgcagtc atatttttta cacaattctc taatcccgac aaggtcgtag gtcgttatag 960

gaaaattctt agcaccattc cggaacaatc agaacagcag gccatgaacg actgacaaca 1020

ttacgaatat aaaaaacgca cccgggccag acattccccc tactgattaa accagccgga 1080

cttgtccacg gaacggtctt tttaaaccga cacacagtct gagtacagat acatgtcacg 1140

atgatgcagg attagcggaa gagtgtgagc acgtttccgg gaactgtggt gaaccatagc 1200

tcaatattcg agtgagggca taccggaaac gcgctcagat tcgttgtaac gcgattttcc 1260

gtaccgggca attttttcag ttgttttttc gtttcatgtc gtcagaaacg ttctgagcgc 1320

gtttccggca tctgatgcta cgcaaaccat ccccatggtc agttgacagc cggaaacacg 1380

cgggtgtcgt tttagcgtat cgacgggacg gcgtcgagaa gcacaaaaaa cagatgttgt 1440

actcagtcag ttgttttaca gacagcactg cggcagattg aaaaagtacc gtactttcag 1500

gaatgtccag aaaccatgtg tcagacttcg ttctccccct tccgggtgaa tttttttgtc 1560

atccgttcag gaatctcttt ataacgatta ctccatttca ggatttttta tgtggcgttt 1620

actacaggca ggatattcaa aggcaaaaaa atcccccgga acaggcggaa cccggacagg 1680

gggagaacga atcgctaaat aattttcgta gttgtatttc ccatcgttgc tactgcaacg 1740

ggatgaattt gccgcagttt atcctgtaaa acaatcctga tttactcaca ctccacatat 1800

cactgacgga gcacaacgga atagtgaaca aacaacaaca aactgcgctg aatatggcgc 1860

gatttatcag aagccagagc ctgatactgc ttgaaaaact ggatgctctg gatgccgacg 1920

agcaggcggc catgtgtgaa cgactgcacg aactcgcgga agaactccag aacagcatcc 1980

aggctcgctt tgaagccgaa agtgaaacag gaacataacg aagctcccgg agacggtcac 2040

agcttgtctg tgaacggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggttt 2100

tagcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag tgtatactgg 2160

cttagtcatg cggcatcagt gcggattgta tgaaaagtgc accatgtacg gtgtgaaatg 2220

ccgcacagat gcgtaaggag aacatgcaga tgccgatgct cttccgcttc ctcgctcact 2280

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtgt ctgctcactc aaaagcggtg 2340

atactgttat ccacacaatc aggggataac gccggaaaga acatgtgagc aaaaaacgaa 2400

gaccccagaa aaggccgcgc cggaggcgct ttttccatag gctccgcccc cctgacgagc 2460

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggactt aaagatacca 2520

ggcgtttccc cccggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg 2580

atacctctcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgttg 2640

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt 2700

tcagcccgac cactgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca 2760

cgactttacg ccactggcag cagccattgg taactgaaaa gtggatttag atacgcagaa 2820

ctcttgaagt tgaagcctta tcgcggctac actgaaagga cagcatttgg tatctgtgct 2880

ccacttaagc cagctaccac aggttagaaa gcctgagaaa cttctaacct tcgaaagaac 2940

ccacgcctga gaacgtgggt tttttcgttt acaggcagca gattacgcgc agaaaaaaag 3000

gatctcaaga agatcctttg atcttttcta ctgaattgcg ctcccgatca gttcagcaga 3060

agattatgat ggggttctat gggtattgct gcggtaacac ccatgttact tgaggttgta 3120

tgtagtctgt gtagaattat acacataagg cttaaactgc tctttttttt caatatgcaa 3180

ttggaagttc attgactaca taaatagatt attccaaata atttatttat gtaagaacag 3240

gatgggaggg ggaatgatct caaagttatt ttgcttggct ctcatatttt tatcatcaag 3300

tggccttgca gaaaaaaaca catatacagc aaaagacatc ttgcaaaacc tagaattaaa 3360

tacctttggc aattcattgt ctcatggcat ctatgggaaa cagacaacct tcaagcaaac 3420

cgagtttaca aatattaaaa gcaacaccaa aaaacacatt gcacttatca ataaagacaa 3480

ctcatggatg atatcattaa aaatactagg aattaagaga gatgagtata ctgtctgttt 3540

tgaagatttc tctctaataa gaccgccaac atatgtagcc atacatcctc tacttataaa 3600

aaaagtaaaa tctggaaact ttatagtagt gaaagaaata aagaaatcta tccctggttg 3660

cactgtatat tatcattaat agcaagcccc tcattattat gaggggctca tggttatttt 3720

aacaatccac tatcgatatc tttttgcacc agagcgccct ctcgtttacg tctgtcagac 3780

attccatcaa caatattatt aaaagcattt acaaggccat tccagtcttt tgcgataact 3840

ttattccata ctgtgggagc agttctggat aacttaaacc ctttttgata tccaatagac 3900

accagtgctg tacgggttct caacggtaaa tcgctgaacc gaagaccgat attagcgtca 3960

ttgaaaagac cttcaatctt atgtgagaat ttatcaatat aaatattaga taagagatga 4020

gcttcattat cagaaagcgt cagaggtgct gttctcactt tatcataagc ctccttccct 4080

cgaagcatat aatacccatc aagtctatct gcaatatact gagggacacc gtcattcaat 4140

aaatcctgtt tgcttcgctg accaaggtca accccggaac cgaatgtaac accggtactg 4200

ttaaaataat cgctactagg attagacgga aaatgacttg tcggattaaa cccttcaaaa 4260

ccattactgg agaaaatatc gtggtcaaca atatttaccg aacgacgtaa aaattccttc 4320

agttgactaa tattgtcaaa gttaatgaca gtgttgtccg ctaggacgat gcgatttcgg 4380

ttattattca gaatgtcttc gttctctttc twatcgagat gttcaataga ttcggcaatc 4440

gttccctcaa gaaccatgac acggtagact ttcacaccgt ctttttcctg acctgtttca 4500

acagttattt tctgttcgta agacacggtc ccttcagttt ttgaaatttt actttcctgg 4560

cggatcttat ttgaatattc actgtctttc tccatctccg tatcaatcgg aaaccccata 4620

atgtacatca gtttaaaatt actccggcca ggcagatcca cataatgtgg taatgcaatt 4680

gtaatcgaat tagcttcaaa atttggtctg taactgctta atgtacttcc ggaaaagaga 4740

aaagccggaa caccacctga accattcact accattgtat ctgacataaa aattcctctt 4800

taacacataa aaaaacaata agttaaaaaa aaatactgta cataaaacca ctgtttttat 4860

gtacagtaat aaaattacgc cgctttattt tctctgtcaa taatatgaaa tttcattttt 4920

gtgatctgaa tcactcttat aaaaatcagg aagggaagat tcgcagcaga aaaacagcac 4980

cgggtaacat cagaaaaaaa cagaaaggag ataacgtgag caaaacaaaa tctggtcgcc 5040

accgactgag caaaacagac aaacgcctgc tggctgcact tgtcgttgcc ggatacgaag 5100

aacggacagc ccgtgacctc atccagaaac acgtttacac actgacacag gccgacctgc 5160

gccatctggt cagtgaaatc agtaacggtg tgggacagtc acaggcctac gatgcgattt 5220

accaggcgag acgcattcgt ctcgcccgta aatacctgag cggaaaaaaa ccggaagggg 5280

tggaaccccg ggaagggcag gaacgggaag atttaccata actcccgtta tcagtaccat 5340

cggctcaacg ctcgttgtcg gatctgaaaa attcgctcaa aagatcatat ttccctggat 5400

attttccacc gtttcttatg tgagcaaagt cacataattc tgtcagacga cgagaaaacg 5460

gatatcgatt attgtttaat atttttacat tattaaaaat gaaattagat aatcagatac 5520

aaataatatg ttttcgttca tgcagagaga ttaagggtgt ctaatgaaga aaagttctat 5580

tgtggcaacc attataacta ttctgtccgg gagtgctaat gcagcatcat ctcagttaat 5640

accaaatata tcccctgaca gctttacagt tgcagcctcc accgggatgc tgagtggaaa 5700

gtctcatgaa atgctttatg acgcagaaac aggaagaaag atcagccagt tagactggaa 5760

gatcaaaaat gtcgctatcc tgaaaggtga tatatcctgg gatccatact catttctgac 5820

cctgaatgcc agggggtgga cgtctctggc ttccgggtca ggtaatatgg atgactacga 5880

ctggatgaat gaaaatcaat ctgagtggac agatcactca tctcatcctg ctacaaatgt 5940

taatcatgcc aatgaatatg acctcaatgt gaaaggctgg ttactccagg atgagaatta 6000

taaagcaggt ataacagcag gatatcagga aacacgtttc agttggacag ctacaggtgg 6060

ttcatatagt tataataatg gagcttatac cggaaacttc ccgaaaggag tgcgggtaat 6120

aggttataac cagcgctttt ctatgccata tattggactt gcaggccagt atcgcattaa 6180

tgattttgag ttaaatgcat tatttaaatt cagcgactgg gttcgggcac atgataatga 6240

tgagcactat atgagagatc ttactttccg tgagaagaca tccggctcac gttattatgg 6300

taccgtaatt aacgctggat attatgtcac acctaatgcc aaagtctttg cggaatttac 6360

atacagtaaa tatgatgagg gcaaaggagg tactcagacc attgataaga atagtggaga 6420

ttctgtctct attggcggag atgctgccgg tatttccaat aaaaattata ctgtgacggc 6480

gggtctgcaa tatcgcttct gaaaaataca gatcatatct ctcttttcat cctcccctag 6540

cggggaggat gtctgtggaa aggaggttgg tgtttgacca accttcagat gtgtgaaaaa 6600

tcaccttttt caccataatg acggggcgct cattctgttg ttttgccttg acattctcca 6660

cgtctttcag ggcatggaga aggtcaaatt agacatggaa cgctactctc cttcctgtag 6720

gaagctcaac atccaagctt aatttgcctc ccattgcttc aacgtaacgc tttaacgtcg 6780

ccagctttaa atcatttccg cgctgctcca gctttgttac tgctggctgg cttataccca 6840

tcgcctcagc aacttgtttt tgtgataact ggagttcttc acgcatcatc tgcaagccga 6900

cctcaagaat catctcatct gccatttctt taattcgtgt ctggctttca ggtgaacgac 6960

tggcaatcac ctcatctaat gttctcatta cttgctctcc agtgtgttca gatgtgctgt 7020

aaattcatcc tcagctatac gcaccagttt ttcataaaac cgcttatcat tacttttatc 7080

tcctgcacaa agaacgatag cccgacgaat cggatcgaac gcataaaagg ctcttatcgg 7140

acggccagaa aactgaacgc gaagctcttt catatttttg taccgagaac ctttcacggt 7200

atcggcatat ggcctgggta actcaggtcc gtaaacctgt agctttttca aatcagccaa 7260

aaccttttcc tgaagagcgt cttcttgctc atttagccag tcgtcaaatc gctggctaaa 7320

aagtaccatc cacatgctca accctataac ctgtagctta ccccactaac aatataacct 7380

acgagttata ttttcaagaa aagctggcta tttaacataa cggcaatttg tacgcaccac 7440

tgaaatgcgt tcagcgcgat cacggcaaca gacaggcaaa aatagcaaca aacctcccga 7500

aaaaccgccg cgatcgcgcc tgataaattt taaccttatg catatctatg cagccaggcg 7560

aatcacgaac gaattgcctg cctgatgtaa ctgaaacggg tgttttttcc tgatttggtg 7620

ggcgtggaag acggaacatg aacgggaaaa cagaattcat gccagatgag cgcgatctgg 7680

caattaaggc aaaacacagc aacaaagaca cgccagaatc gcgcccggat atgttttaac 7740

gcgattttca gactcagaca aattcagcag aatgctactc cattcaccgg gctgatggtg 7800

aatacatgcg tatccaggat gagtacattt ctggctctgc cacagctctg tctgttggca 7860

gctttcgcct gtccggaaac ctgcttaaaa cgctcccgaa aggcctctga accagaaagc 7920

aacaaaacac aggccattaa gtaaatcgcg ttaaaacacg tctgatggat tgctgcaaaa 7980

aaaagtccct aatggagcag ggactgttaa acccagtgaa tagcgtctaa attaaagtaa 8040

gaatacgacc aggtactctt cagaaaagag attaatccac cgcacagaat aatcaacagt 8100

aaaaacaaac aaccctgatt ttttattttt ctttttttcg ataaaaacaa aattaaagaa 8160

ataattaatc agaacattcc ttaacttcag ggcattgcct gtgttccatt ttgtgattag 8220

tctgaaactt ccgaaggtgg ataacacccg gtattttttt gctcacataa agcccctcct 8280

tcaggcagag gggctttttc tttgccacca cataaaaaag gccctcacag gaggtgttct 8340

gtgagggcgt atgataagga ctgaatcgat ggttaatatg tctagtcctg acttttgcat 8400

ctccgaatat aaaaccctgt ttaacggcat gcaaaaccaa aaaataaaaa tgtgacatcg 8460

caatgccaga taatattgac gcatgaggga atgcgtaccc cgacccctgt gtaacgaacg 8520

gtgcaatagt gatccacacc caacgcctga aatcagatcc agggggtaat ctgctctcct 8580

gattcaggag agtttatggt cacttttgag acagttatgg aaattaaaat cctgcacaag 8640

cagggaatga gtagccgggc gattgccaga gaactgggga tctcccgcaa taccgttaaa 8700

cgttatttgc aggcaaaatc tgagccgcca aaatatacgc cgcgacctgc tgttgcttca 8760

ctcctggatg aataccggga ttatattcgt caacgcatcg ccgatgctca tccttacaaa 8820

atcccggcaa cggtaatcgc tcgcgagatc agagaccagg gatatcgtgg cggaatgacc 8880

attctcaggg cattcattcg ttctctctcg gttcctcagg agcaggagcc tgccgttcgg 8940

ttcgaaactg aacccggacg acagatgcag gttgactggg gcactatgcg taatggtcgc 9000

tcaccgcttc acgtgttcgt tgctgttctc ggatacagcc gaatgctgta catcgaattc 9060

actgacaata tgcgttatga cacgctggag acctgccatc gtaatgcgtt ccgcttcttt 9120

ggtggtgtgc cgcgcgaagt gttgtatgac aatatgaaaa ctgtggttct gcaacgtgac 9180

gcatatcaga ccggtcagca ccggttccat ccttcgctgt ggcagttcgg caaggagatg 9240

ggcttctctc cccgactgtg tcgccccttc agggcacaga ctaaaggtaa ggtggaacgg 9300

atggtgcagt acacccgtaa cagtttttac atcccactaa tgactcgcct gcgcccgatg 9360

gggatcactg tcgatgttga aacagccaac cgccacggtc tgcgctggct gcacgatgtc 9420

gctaaccaac gaaagcatga aacaatccag gcccgtccct gcgatcgctg gctcgaagag 9480

cagcagtcca tgctggcact gcctccggag aaaaaagagt atgacgtgca tcttgatgaa 9540

aatctggtga acttcgacaa acaccccctg catcatccac tctccatcta cgactcattc 9600

tgcagaggag tggcgtgatg atggaactgc aacatcaacg actgatggcg ctcgccgggc 9660

agttgcaact ggaaagcctt ataagcgcag cgcctgcgct gtcacaacag gcagtagacc 9720

aggaatggag ttatatggac ttcctggagc atctgcttca tgaagaaaaa ctggcacgtc 9780

atcaacgtaa acaggcgatg tatacccgaa tggcagcctt cccggcggtg aaaacgttcg 9840

aagagtatga cttcacattc gccaccggag caccgcagaa gcaactccag tcgttacgct 9900

cactcagctt catagaacgt aatgaaaata tcgtattcac tggggccatt caggtgtggg 9960