Display screen with multi-panel active content graphical user interface

FIG. 1 is a front view of a display screen with a multi-panel active content graphical user interface showing the first embodiment of our new design;

FIG. 2 is a front view thereof, in the context of additional environment;

FIG. 3 is a front view of a second embodiment thereof;

FIG. 4 is a front view of a third embodiment thereof; and,

FIG. 5 is a front view of a fourth embodiment thereof.

The broken lines showing the display screen and portions of the graphical user interface in FIGS. 1-5 form no part of the claimed design. The broken lines showing of the device in FIGS. 2-5 illustrate environment and form no part of the claimed design.