Solid preparations containing tofogliflozin and process of producing the same

The present invention relates to solid preparations containing tofogliflozin, namely, 1,1-Anhydro-1-C-[5-(4-ethylphenyl)methyl-2-(hydroxymethyl)phenyl]-β-D-glucopyranose, which is a spiroketal derivative, and the process of producing the preparations.

A spiroketal derivative having a certain structure has been known as being useful for preventing or treating diabetes (Patent Documents 1 and 2). For example, WO 2006/080421 (Patent Document 1) discloses a compound represented by the following formula (I), generic name of which is tofogliflozin (chemical name: 1,1-Anhydro-1-C-[5-(4-ethylphenyl)methyl-2-(hydroxymethyl)phenyl]-β-D-glucopyranose), and states that the compound has an excellent inhibitory activity against SGLT2.

Further, WO 2009/154276 (Patent Document 2) discloses a monohydrate crystal, a co-crystal with sodium acetate, and a co-crystal with potassium acetate of the compound represented by formula (I). The document further discloses that the monohydrate crystal (hereafter referred to as crystal form I) has peaks at diffraction angles (2θ) of about 3.5°, 6.9°, 10.4°, 13.8°, 16.0°, 17.2°, 18.4°, 20.8°, 21.4°, and 24.4° in X-ray powder diffraction pattern; the co-crystal with sodium acetate has peaks at diffraction angles (2θ) of about 4.9°, 8.7°, 9.3°, 11.9°, 12.9°, 14.7°, 16.0°, 17.1°, 17.7°, 19.6°, 21.6° and 22.0° in X-ray powder diffraction pattern; and the co-crystal with potassium acetate has peaks at diffraction angles (2θ) of about 5.0°, 10.0°, 10.4°, 12.4°, 14.5°, 15.1°, 19.0°, 20.1°, 21.4° and 25.2° in X-ray powder diffraction pattern.

Furthermore, WO 2012/115249 (Patent Document 3) discloses a monohydrate crystal of the compound represented by formula (I), and the monohydrate crystal (hereafter referred to as crystal form II) is characterized as having peaks at diffraction angles (2θ) of about 4.0°, 7.5°, 10.8°, 12.7°, 14.0°, 14.7°, 18.0°, 18.8°, 19.5°, and 22.7° in X-ray powder diffraction pattern. The document further discloses that an acetone-water solvate crystal (hereafter referred to as crystal form III) of the compound represented by formula (I) has peaks at diffraction angles (2θ) of about 11.0°, 12.3°, 19.2°, 20.2°, and 21.6° in X-ray powder diffraction pattern.

A pharmaceutical preparation containing a low-melting point drug significantly deteriorates in quality due to melting of the drug during storage at a high temperature, and this has been problematic. In powders or granules, melting of a drug causes coagulation. In tablets, melting of a drug causes problems, such as oozing of the drug, mottling, or changing in color, during storage, and adhesion of the tablet material to the tableting machine at tableting (sticking). To cope with such problems, JP 2006-160730 A (Patent Document 4) discloses producing granules from a mixture of an adsorbing carrier, such as calcium silicate, magnesium hydroxide-aluminium hydroxide co-precipitate, or synthetic hydrotalcite, with a low-melting point drug, as a means for handling problems, such as oozing of a low-melting point substance and coagulation of powders and granules, that arise during storage at a high temperature as well as tableting defects such as sticking. Further, JP H10-287561 A reports a solid preparation obtained by adsorbing ibuprofen having a low melting point on a porous excipient, such as calcium silicate or light silicic anhydride.

JP S56-145214 A (Patent Document 6) discloses obtaining tablets by adding silicates to a low-melting point substance as a stabilizer to increase the eutectic point and prevent melting of the substance, thereby to reduce variation in the content of the low-melting point substance from tablet to tablet and reduce changes in properties such as dissolution and hardness. JP S63-243034 A (Patent Document 7) discloses a solid preparation obtained by blending a low-melting point substance with calcium silicate that adsorbs the substance, thereby to reduce sticking. JP 2000-239185 A (Patent Document 8) discloses a pharmaceutical composition which has been granulated using light silicic anhydride to reduce, for example, sticking and the influence on stimulatory components (e.g., bitterness). JP 2005-104934 A (Patent Document 9) discloses a composition obtained by melting a low-melting point substance by initially blending it with calcium silicate, so as to prevent tablet-to-tablet variation in drug content at tabletting caused by melt of the low-melting point substance or to prevent prolonged disintegration time (to improve stability during storage).

From the production point of view, tablets are largely divided into following groups: compressed tablets, which are produced by compressing a medicine to a certain shape, and molded tablets, which are produced by moistening the ingredients of a medicine with a solvent and forming, or molding, the moistened mixture into a certain shape. The production of the compressed tablets is the highest of all dosage forms. Examples of typical production methods of the compressed tablets include direct powder compression (direct compression) and wet granulation compression. The direct compression is a process by which a medicinal agent and additives in powder form are mixed and the mixture is directly compressed into tablets. This process requires the fewest steps and is economical, whereas it may cause problems such as insufficient tablet hardness, powdery tablet surface, and lack of content uniformity from tablet to tablet or within each tablet. The wet granulation is a process in which a medicinal agent and additives are granulated by wet method and the granules are pressed into tablets. Although this process requires many steps, it is widely used due to many advantages it offers; for example, a medicinal agent is easy to be distributed uniformly in tablets, and covering the surface of a poorly water-soluble medicinal agent with a hydrophilic polymer (binder) can improve the dissolution and hardness of the tablets as well as prevent powders from appearing on the tablet surfaces (Non-Patent Document 1).

Patent Documents

Patent Document 1: WO 2006/080421

Patent Document 2: WO 2009/154276

Patent Document 3: WO 2012/115249

Patent Document 4: JP 2006-160730 A

Patent Document 5: JP H10-287561 A

Patent Document 6: JP S56-145214 A

Patent Document 7: JP S63-243034 A

Patent Document 8: JP 2000-239185 A

Patent Document 9: JP 2005-104934 A

Non-Patent Documents

Non-Patent Document 1: Yamamoto, K, Editorial supervisor; “Basics of Science of Drug Formulation”; Elsevier Japan; Dec. 5, 2008; pp 126-129

Technical Problem

Nothing has been reported about solid preparations of tofogliflozin, which is a low-melting point compound (the crystal form I has a melting point of about 71° C.), that can be used as pharmaceuticals. In addition, the inventors of the present application have investigated the production of solid preparations of tofogliflozin and have found that conventional production methods and formulations would not give solid tofogliflozin preparations having sufficient disintegration and dissolution properties.

In view of the foregoing, an object of the present invention is to provide solid preparations containing tofogliflozin with improved disintegration and dissolution properties.

Solution to Problem

The inventors have found that mixing tofogliflozin with at least one filler, at least one disintegrant, and/or at least one lubricant, and then tableting the mixture by direct compression can produce tablets with improved disintegration and dissolution properties. Further, the inventors have found that the disintegration and dissolution properties can be improved by adjusting the weight ratio of calcium silicate to a certain low level.

The present invention has been attained based on such findings and, more specifically, the present invention provides the following [1] to [27].

[1] A pharmaceutical composition comprising tofogliflozin as an active ingredient, wherein the composition is a tablet obtained by direct compression of a powder mixture of at least one additive with tofogliflozin, and the additive comprises at least one excipient.

[2] The pharmaceutical composition of [1], wherein the excipient is selected from the group consisting of corn starch, potato starch, wheat starch, rice starch, partial alpha starch, alpha starch, lactose hydrate, fructose, glucose, mannitol, anhydrous dibasic calcium phosphate, crystalline cellulose, and precipitate calcium carbonate.

[3] The pharmaceutical composition of [1] or [2], wherein the additive further comprises at least one disintegrant.

[4] The pharmaceutical composition of [3], wherein the disintegrant is selected from the group consisting of sodium starch glycolate, carboxymethyl cellulose, carboxymethylcellulose calcium, carboxymethyl starch sodium, croscarmellose sodium, crospovidone, low substituted hydroxypropylcellulose, and hydroxypropyl starch.

[5] The pharmaceutical composition of any one of [1] to [4], wherein the additive further comprises at least one lubricant.

[6] The pharmaceutical composition of [5], wherein the lubricant is selected from the group consisting of magnesium stearate, calcium stearate, talc, sucrose fatty acid ester, sodium stearyl fumarate, and hydrogenated oil.

[7] The pharmaceutical composition of any one of [1] to [6], the composition being substantially free from calcium silicate.

[8] The pharmaceutical composition of any one of [1] to [7], wherein the tofogliflozin consists of a crystal form I, a crystal form II, a crystal form III, a co-crystal with sodium acetate, a co-crystal with potassium acetate, an amorphous form, or a mixture thereof.

[9] The pharmaceutical composition of [8], wherein the tofogliflozin consists of a crystal form I, a crystal form II, an amorphous form, or a mixture thereof.

[10] The pharmaceutical composition of any one of [1] to [9], wherein a weight ratio of the active ingredient tofogliflozin ranges from 2.5 to 40 wt % with respect to the total weight of the composition.

[11] The pharmaceutical composition of any one of [5] to [10], wherein the lubricant accounts for less than 4.0 wt % of the total weight of the composition.

[12] The pharmaceutical composition of any one of [3] to [11], wherein the excipient accounts for 20 to 80 wt % of the total weight of the composition and the disintegrant accounts for 1.0 to 4.0 wt % of the total weight of the composition.

[13] The pharmaceutical composition of any one of [1] to [12], wherein the additive contains excipients, a disintegrant, and a lubricant, the excipients being lactose hydrate and crystalline cellulose, the disintegrant being croscarmellose sodium, and the lubricant being hydrogenated oil, magnesium stearate, or a mixture thereof.

[14] A method for producing a pharmaceutical composition which is a tablet comprising tofogliflozin as an active ingredient, wherein the method comprises:

mixing an additive and tofogliflozin to prepare a powder mixture, and

obtaining a tablet from the powder mixture by direct compression,

wherein the additive comprises at least one excipient.

[15] The method of [14], wherein the excipient is selected from the group consisting of corn starch, potato starch, wheat starch, rice starch, partial alpha starch, alpha starch, lactose hydrate, fructose, glucose, mannitol, anhydrous dibasic calcium phosphate, crystalline cellulose, and precipitate calcium carbonate.

[16] The method of [14], wherein the additive further comprises at least one disintegrant.

[17] The method of [16], wherein the disintegrant is selected from the group consisting of sodium starch glycolate, carboxymethyl cellulose, carboxymethylcellulose calcium, carboxymethyl starch sodium, croscarmellose sodium, crospovidone, low substituted hydroxypropylcellulose, and hydroxypropyl starch.

[18] The method of any one of [14] to [17], wherein the additive further comprises at least one lubricant.

[19] The method of [18], wherein the lubricant is selected from the group consisting of magnesium stearate, calcium stearate, talc, sucrose fatty acid ester, sodium stearyl fumarate, and hydrogenated oil.

[20] The method of any one of [14] to [19], wherein wherein the composition is substantially free from calcium silicate.

[21] The method of any one of [14] to [20], wherein the tofogliflozin comprises a crystal form I, a crystal form II, a crystal form III, a co-crystal with sodium acetate, a co-crystal with potassium acetate, an amorphous form, or a mixture thereof.

[22] The method of [21], wherein the tofogliflozin comprises a crystal form I, a crystal form II, an amorphous form, or a mixture thereof.

[23] The method of any one of [14] to [22], wherein a weight ratio of the active ingredient tofogliflozin ranges from 2.5 to 40 wt % with respect to the total weight of the composition.

[24] The method of any one of [18] to [23], wherein the lubricant accounts for less than 4.0 wt % of the total weight of the composition.

[25] The method of any one of [16] to [24], wherein the filler accounts for 20 to 80 wt % of the total weight of the composition and the disintegrant accounts for 1.0 to 4.0 wt % of the total weight of the composition.

[26] The method of any one of [14] to [25], wherein the additive comprises lactose hydrate, crystalline cellulose, croscarmellose sodium, and hydrogenated oil and/or magnesium stearate.

[27] A solid preparation comprising tofogliflozin as an active ingredient, lactose hydrate, crystalline cellulose, croscarmellose sodium, and hydrogenated oil and/or magnesium stearate.

[28] The solid preparation of [27] having a dosage form selected from a tablet, a capsule, or a granule.

A skilled person in the art would appreciate that the present invention includes any one or any combination of two or more of the embodiments above, if they are technically consistent with one another based on common technical knowledge of those skilled in the art.

Advantageous Effects of Invention

According to the present invention, solid preparations with improved disintegration and dissolution properties are provided. Further, the invention provides a solid preparation with improved disintegration and dissolution properties by adjusting the weight ratio of calcium silicate, which is an additive of the solid preparation, to a low level. The use of the method of the present invention makes it possible to provide a solid preparation that allows a rapid release of a drug component.

FIG. 1 is a diagram showing a relation between the hardness and the dissolution time of a tablet containing 20 wt % of the active ingredient tofogliflozin hydrate (crystal form I) for a case where the tablet was produced by direct compression and a case where the tablet was produced by wet granulation (Test Example 2).

Using the f2 function values obtained in Test Example 8, a factor analysis was performed using quality engineering (the Taguchi method, L18).

FIG. 2 is a cause and effect diagram that uses the condition levels (formulation condition) shown in Table 6.

FIG. 3 is a diagram showing a relation between the disintegration time and the compression pressure for each of an initial product and an accelerated product of tablets containing 40 wt % of the active ingredient tofogliflozin hydrate (crystal form I) produced by direct compression (Test Example 1).

FIG. 4 is a diagram showing a relation between the disintegration time and the compression pressure for each of an initial product and an accelerated product of tablets containing 40 wt % of the active ingredient tofogliflozin hydrate (crystal form I) produced by wet granulation (Test Example 1).

The present invention relates to a pharmaceutical composition comprising tofogliflozin as an active ingredient, the composition being a tablet obtained by direct compression of a powder mixture of at least one additive with tofogliflozin, the additive comprising at least one filler. Further, the present invention relates to a method of producing the composition.

The term “tofogliflozin” as used in the present invention refers to a compound having the chemical name, 1,1-Anhydro-1-C-[5-(4-ethylphenyl)methyl-2-(hydroxymethyl)phenyl]-β-D-glucopyranose, and being represented by formula (I).

The “filler” as used in the present invention is exemplified by saccharides (e.g., lactose, lactose hydrate, fructose, glucose), sugar alcohols (e.g., mannitol), starches (e.g., corn starch, potato starch, wheat starch, rice starch, partial alpha starch, alpha starch), celluloses (e.g., crystalline cellulose) and inorganic salts (e.g., calcium silicate, anhydrous dibasic calcium phosphate, precipitate calcium carbonate), more specifically, corn starch, potato starch, wheat starch, rice starch, partial alpha starch, alpha starch, lactose hydrate, fructose, glucose, mannitol, anhydrous dibasic calcium phosphate, crystalline cellulose, and precipitate calcium carbonate, and more preferably, lactose and crystalline cellulose.

The “disintegrant” as used in the present invention is exemplified by starch, sodium glycolate, carboxymethyl cellulose, carboxymethylcellulose calcium, carboxymethyl starch sodium, croscarmellose sodium, crospovidone, low substituted hydroxypropylcellulose, and hydroxypropyl starch. More preferably, such a disintegrant is croscarmellose sodium, for example.

The “lubricant” as used in the present invention is exemplified by magnesium stearate, calcium stearate, talc, sucrose fatty acid ester, sodium stearyl fumarate, and hydrogenated oil. More preferably, such a lubricant is magnesium stearate or hydrogenated oil, for example.

In addition to the ingredients stated above, the solid preparation according to the present invention may contain typically used agents such as binders, lubricating and coloring agents, or flavoring agents, and also may contain, at need, stabilizers, emulsifiers, absorbefacients, surfactants, pH modifiers, antiseptics, antioxidants, or the like. The solid preparations may be formulated by combining ingredients commonly used as raw materials of solid preparations.

The “additive” as used in the present invention is intended to refer to ingredients commonly used as raw materials of solid preparations, examples of which may include fillers, disintegrants, lubricants, binders, lubricating and coloring agents, flavoring agents, stabilizers, emulsifiers, absorbefacients, surfactants, pH modifiers, antiseptics, and antioxidants.

The “solid preparation” as used herein refers to dosage forms such as tablets, powders, fine granules, granules, coated tablets, capsules, dry syrups, troches, suppositories. The dosage form refers to the form itself of a finished pharmaceutical product or the like. The dosage form of the solid preparation according to the present invention is preferably capsules, tables, or granules, and more preferably, capsules or tablets, but other forms may be used if they have ingredients typically used in the field of pharmaceutical formulation and typical shapes and sizes.

The hardness of tablets can be adjusted according to, for example, the type of additives used in preparing the tablets or the compression pressures. The compression pressure used in forming the pharmaceutical composition of the present invention ranges, for example, from 5 to 20 kN, more specifically, from 6.5 to 18.5 kN, and still more specifically, from 8 to 12 kN. Further, the hardness of the tablet of the pharmaceutical composition of the present invention ranges, for example, from 20 to 200 N, more specifically, from 30 to 150 N, and still more specifically, from 50 to 100 N.

Colorants that are allowed to be added to pharmaceuticals may be used in the composition. The flavoring agents to be used may include cocoa powder, menthol, aromatic powder, mentha oil, Borneo camphor, and cinnamon powder.

Of course, such tablets or granules may be coated with sugar coating or other suitable coating, as appropriate. Further, in producing a liquid preparation such as a syrup or injection, agents such as pH modifier, solvent, and tonicity agent, plus agents such as solubilizer and stabilizer, as appropriate, are added to a compound according to the present invention or a pharmacologically acceptable salt thereof to formulate the preparation.

The “crystal form I” as used in the present invention refers to a monohydrate crystal of the compound represented by formula (I). The monohydrate crystal is disclosed to have peaks at diffraction angles (2θ) of about 3.5°, 6.9°, 10.4°, 13.8°, 16.0°, 17.2°, 18.4°, 20.8°, 21.4°, and 24.4° in X-ray powder diffraction pattern (Patent Document 2).

The “crystal form II” as used in the present invention refers to a monohydrate crystal of the compound represented by formula (I). It is disclosed that the monohydrate crystal is characterized as having peaks at diffraction angles (2θ) of about 4.0°, 7.5°, 10.8°, 12.7°, 14.0°, 14.7°, 18.0°, 18.8°, 19.5°, and 22.7° in X-ray powder diffraction pattern (Patent Document 3).

The “crystal form III” as used in the present invention refers to an acetone-water solvate crystal of the compound represented by formula (I). It is disclosed that the acetone-water solvate crystal has peaks at diffraction angles (2θ) of about 11.0°, 12.3°, 19.2°, 20.2°, and 21.6° in X-ray powder diffraction pattern (Patent Document 3).

The “co-crystal with sodium acetate” as used in the present invention refers to a co-crystal with sodium acetate of the compound represented by formula (I). It is disclosed that the co-crystal with sodium acetate has peaks at diffraction angles (2θ) of about 4.9°, 8.7°, 9.3°, 11.9°, 12.9°, 14.7°, 16.0°, 17.1°, 17.7°, 19.6°, 21.6° and 22.0° in X-ray powder diffraction pattern (Patent Document 2).

The “co-crystal with potassium acetate” as used in the present invention refers to a co-crystal with potassium acetate of the compound represented by formula (I). It is disclosed that the co-crystal with potassium acetate has peaks at diffraction angles (2θ) of about 5.0°, 10.0°, 10.4°, 12.4°, 14.5°, 15.1°, 19.0°, 20.1°, 21.4° and 25.2° in X-ray powder diffraction pattern (Patent Document 2).

Preferably, tofogliflozin used in the solid preparation of the present invention is selected from the group consisting of a crystal form I, a crystal form II, a crystal form III, a co-crystal with sodium acetate, a co-crystal with potassium acetate, an amorphous form, or a mixture thereof. More preferably, tofogliflozin used in the solid preparation is selected from the group consisting of a crystal form I, a crystal form II, an amorphous form, or a mixture thereof. Still more preferably, tofogliflozin used in the solid preparation is a crystal form I. The proportions of crystal forms contained in tofogliflozin can be determined by using the NRI measurement, solid-state NMR, X-ray powder diffraction method, Raman spectrometry, or the like.

The solid preparation of the present invention is produced by mixing not only tofogliflozin and at least one filler but also at least one disintegrant and/or at least one lubricant and then direct compressing the mixture. Further, the present invention provides a method for producing a solid preparation that contains tofogliflozin, at least one filler, and at least one disintegrant and/or at least one lubricant and which is formed by direct compression.

The “direct compression” as used in the present invention refers to a process by which an active ingredient and additives in powder form are mixed and the mixture is directly compressed into tablets. The “wet granulation” refers to a process in which a medicinal agent and additives are granulated by wet method and the granules are pressed into tablets. The “wet method” refers to a process of producing granular mass by mixing a medicinal agent and an additive, and then spraying water directly on the powder mixture or placing a paste-form aqueous solution, in which a binder has been dissolved or dispersed, on the powder mixture.

The compression pressure used in tablet making may be adjusted depending on the ingredients or the required hardness of a tablet. The tablet hardness can be adjusted according to, for example, the type of additives used in preparing the tablet or the compression pressure. The compression pressure used in forming the pharmaceutical composition of the present invention ranges, for example, from 5 to 20 kN, more specifically, from 6.5 to 18.5 kN, and still more specifically, from 8 to 12 kN. Further, the tablet hardness of the pharmaceutical composition of the present invention ranges, for example, from 20 to 200 N, more specifically, from 30 to 150 N, and still more specifically, from 50 to 100 N.

The dose of the solid preparation according to the present invention may be selected based on the level of symptom, age, sex, body weight, route of administration, type of salt, specific type of disease, and the like.

The “substantially free from calcium silicate” as used in the present invention refers to that the solid preparation is produced by direct compression such that the weight ratio of calcium silicate in the preparation is preferably less than 2.5% or less than 2.0%, more preferably less than 1.75%, less than 1.5%, less than 1.25%, less than 1.0%, or less than 0.75%.

In a non-limiting embodiment of the present invention, it is preferable, but not limited to, that the solid preparation is substantially free from not only calcium silicate, but also light silicic anhydride, hydrated silicon dioxide, calcium silicate, magnesium hydroxide-aluminium hydroxide co-precipitate, synthetic aluminum silicate, synthetic hydrotalcite, or magnesium aluminometasilicate.

The “weight ratio” as used in the present invention refers to a ratio that compares the weight of an active ingredient or an additive with the total weight of the pharmaceutical preparation.

In an embodiment of the present invention, the weight ratio of tofogliflozin in the solid preparation is preferably, but not limited to, in the range of 1.0 wt % to 80 wt %, 1.0 wt % to 70 wt %, 1.0 wt % to 60 wt %, 1.0 wt % to 50 wt %, 2.5 wt % to 40 wt %, 10 wt % to 40 wt %, or 20 wt % to 40 wt %. The preparation can be produced by using tofogliflozin hydrate, and in that case, the weight ratio of tofogliflozin is calculated based on the weight of tofogliflozin contained in the hydrate.

From the viewpoint of preventing tableting defects, the weight ratio of tofogliflozin in the solid preparation is preferably, but not limited to, 60 wt % or less, 50 wt % or less, 40 wt % or less, 30 wt % or less, or 20 wt % or less. Further, the ratio is preferably, but not limited to, 1.0 wt % or more, 2.5 wt % or more, or 5.0 wt % or more.

In an embodiment of the present invention, the weight ratio of an filler in the solid preparation is preferably, but not limited to, in the rage of 5.0 wt % to 95 wt %, 10 wt % to 90 wt %, 15 wt % to 85 wt %, or 20 wt % to 80 wt %.

In an embodiment of the present invention, the total weight ratio of lactose hydrate and crystalline cellulose in the solid preparation is preferably, but not limited to, in the range of 5.0 wt % to 95 wt %, 10 wt % to 90 wt %, 15 wt % to 85 wt %, or 20 wt % to 80 wt %.

In an embodiment of the present invention, the weight ratio of a disintegrant in the solid preparation is preferably, but not limited to, 50 wt % or less, 30 wt % or less, 20 wt % or less, 10 wt % or less, 8.0 wt % or less, 6.0 wt % or less, 4.0 wt % or less, 2.0 wt % or less, or 1.0 wt % or less.

In an embodiment of the present invention, the weight ratio of croscarmellose in the solid preparation is preferably, but not limited to, 10 wt % or less, 8.0 wt % or less, 6.0 wt % or less, 4.0 wt % or less, 2.0 wt % or less, or 1.0 wt % or less. Further, the ratio is preferably, but not limited to, at least 0.1 wt % or at least 0.5 wt %.

In an embodiment of the present invention, the weight ratio of a lubricant in the solid preparation is preferably, but not limited to, less than 20 wt %, less than 10 wt %, less than 8.0 wt %, less than 6.0 wt %, less than 5.0 wt %, less than 4.0 wt %, less than 3.0 wt %, or less than 2.0 wt %. Further, the ratio is preferably, but not limited to, at least 0.1 wt %, at least 0.5 wt %, or at least 1.0 wt %.

In an embodiment of the present invention, the total weight ratio of hydrogenated oil and magnesium stearate in the solid preparation is preferably, but not limited to, less than 10 wt %, less than 8.0 wt %, less than 6.0 wt %, less than 5.0 wt %, less than 4.5 wt %, less than 4.0 wt %, less than 3.5 wt %, less than 3.0 wt %, or less than 2.5 wt %. Further, the ratio is also preferably, but not limited to, at least 0.1 wt %, at least 0.5 wt %, at least 1.0 wt %, or at least 1.5 wt %.

A non-limiting embodiment of the present invention provides a tablet that contains the active ingredient tofogliflozin in a weight ratio of 20%, lactose hydrate in a weight ratio of 55%, crystalline cellulose in a weight ratio of 20%, croscarmellose sodium in a weight ratio of 2%, and hydrogenated oil and magnesium stearate in total in a weight ratio of 3%.

When the term “and/or” was used in the context of expressing a combination of additives in the specification, the term refers to any possible combination of “and” and “or.” More specifically, for example, an expression “fillers, disintegrants, and/or lubricants” refers to the following variations of additives: (a) fillers, (b) disintegrants, (c) lubricants, (d) fillers and disintegrants, (e) fillers and lubricants, (f) disintegrants and lubricants, and (g) fillers, disintegrants, and lubricants.

A skilled person in the art would appreciate that the present invention includes any one or any combination of two or more of the embodiments above if they are technically consistent with one another based on common technical knowledge of those skilled in the art.

The prior art documents cited are incorporated herein by reference in their entirely.

Comparative Example 1 (Wet Granulation, Tofogliflozin Hydrate Concentration=40%)

In accordance with the formulation and amounts shown in Table 1, tofogliflozin hydrate (crystal form I), lactose hydrate, crystalline cellulose, low substituted hydroxypropylcellulose, and hydroxypropylcellulose were mixed sufficiently in a mortar, and then 3.5 g of purified water was added to the mixture to produce wet granules. The granules were passed through a sieve of 710 μm mesh and then dried in an oven at a temperature of 50° C. for 4 hours. Subsequently, the dried granules were mixed with magnesium stearate in a poly bag. The resultant mixture was compressed using a tabletting device at each of compression pressures of 500 kgf, 1000 kgf, 1500 kgf, and 2000 kgf to form flat tablets (diameter; 7.5 mm, tablet weight; 200 mg). Sticking was observed at the compression pressures 500 kgf and 1000 kgf. Slight sticking was observed at the compression pressures 1500 kgf and 2000 kgf.

[Table 1]

The use of the method of the present invention makes it possible to provide a solid preparation that allows a rapid release of a drug component.