The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I) [structure]

Claims as granted

20 claims

Classifications

17 codes

IPC · International Patent Classification

Section A — Human necessities

A61K31/443
A61K31/496
A61K31/00
A61K31/444
A61K31/4439
A61K31/4545
A61K31/44

Section C — Chemistry; metallurgy

C07D421/00
C07D413/00
C07D401/06
C07D405/00
C07D405/12
C07D213/44
C07D401/12
C07D401/00
C07D413/12
C07D213/79

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Pendency

3.5 y

1,281 days filing → grant

Office actions

after a restriction

Responses

1 RCE

Examiner

Ben S Michelson

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Citations: 55 back · 0 forward

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