This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, Î²-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer\'s disease, erectile dysfunction, and tumor invasion and metastasis.

Description

149 parts

›STATEMENT OF RELATED APPLICATION

The present application is a continuation application of pending U.S. application Ser. No. 10/382,203, filed Mar. 5, 2003, entitled “Azole Derivatives and Fused Bicyclic Azole Derivatives as Therapeutic Agents,” which claims priority under 35 USC 119(e) from U.S. Provisional Application No. 60/361,983, filed Mar. 5, 2002, entitled “Azole Derivatives as Therapeutic Agents,” the entirety of which is herein incorporated by reference.

›FIELD OF THE INVENTION

This invention relates to compounds which are modulators of the receptor for advanced glycated end products (RAGE) and interaction with its ligands such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, for the management, treatment, control, or as an adjunct treatment of diseases caused by RAGE.

›BACKGROUND OF THE INVENTION

Incubation of proteins or lipids with aldose sugars results in nonenzymatic glycation and oxidation of amino groups on proteins to form Amadori adducts. Over time, the adducts undergo additional rearrangements, dehydrations, and cross-linking with other proteins to form complexes known as Advanced Glycosylation End Products (AGEs). Factors which promote formation of AGEs included delayed protein turnover (e.g. as in amyloidoses), accumulation of macromolecules having high lysine content, and high blood glucose levels (e.g. as in diabetes) (Hori et al., J. Biol. Chem. 270: 25752-761, (1995)). AGEs have implicated in a variety of disorders including complications associated with diabetes and normal aging.

AGEs display specific and saturable binding to cell surface receptors on endothelial cells of the microvasculature, monocytes and macrophages, smooth muscle cells, mesengial cells, and neurons. The Receptor for Advanced Glycated Endproducts (RAGE) is a member of the immunoglobulin super family of cell surface molecules. The extracellular (N-terminal) domain of RAGE includes three immunoglobulin-type regions, one V (variable) type domain followed by two C-type (constant) domains (Neeper et al., J. Biol. Chem. 267:14998-15004 (1992)). A single transmembrane spanning domain and a short, highly charged cytosolic tail follow the extracellular domain. The N-terminal, extracellular domain can be isolated by proteolysis of RAGE to generate soluble RAGE (sRAGE) comprised of the V and C domains.

RAGE is expressed in most tissues, and in particular, is found in cortical neurons during embryogenesis (Hori et al., J. Biol. Chem. 270:25752-761 (1995)). Increased levels of RAGE are also found in aging tissues (Schleicher et al., J. Clin. Invest. 99 (3): 457-468 (1997)), and the diabetic retina, vasculature and kidney (Schmidt et al., Nature Med. 1:1002-1004 (1995)). Activation of RAGE in different tissues and organs leads to a number of pathophysiological consequences. RAGE has been implicated in a variety of conditions including: acute and chronic inflammation (Hofmann et al., Cell 97:889-901 (1999)), the development of diabetic late complications such as increased vascular permeability (Wautier et al., J. Clin. Invest. 97:238-243 (1995)), nephropathy (Teillet et al., J. Am. Soc. Nephrol. 11:1488-1497 (2000)), atherosclerosis (Vlassara et. al., The Finnish Medical Society DUODECIM, Ann. Med. 28:419-426 (1996)), and retinopathy (Hammes et al., Diabetologia 42:603-607 (1999)). RAGE has also been implicated in Alzheimer's disease (Yan et al., Nature 382: 685-691, (1996)), erectile dysfunction, and in tumor invasion and metastasis (Taguchi et al., Nature 405: 354-357, (2000)).

In addition to AGEs, other compounds can bind to, and modulate RAGE. In normal development, RAGE interacts with amphoterin, a polypeptide which mediates neurite outgrowth in cultured embryonic neurons (Hori et al., 1995). RAGE has also been shown to interact with EN-RAGE, a protein having substantial similarity to calgranulin (Hofmann et al., Cell 97:889-901 (1999)). RAGE has also been shown to interact with β-amyloid (Yan et al., Nature 389:589-595, (1997); Yan et al., Nature 382:685-691 (1996); Yan et al., Proc. Natl. Acad. Sci., 94:5296-5301 (1997)).

Binding of ligands such as AGEs, S100/calgranulin/EN-RAGE, β-amyloid, CML (N ε -Carboxymethyl lysine), and amphoterin to RAGE has been shown to modify expression of a variety of genes. For example, in many cell types interaction between RAGE and its ligands generates oxidative stress, which thereby results in activation of the free radical sensitive transcription factor NF-κB, and the activation of NF-κB regulated genes, such as the cytokines IL-1β, TNF-α, and the like. In addition, several other regulatory pathways, such as those involving p21ras, MAP kinases, ERK1 and ERK2, have been shown to be activated by binding of AGEs and other ligands to RAGE. In fact, transcription of RAGE itself is regulated at least in part by NF-κB. Thus, an ascending, and often detrimental, spiral is fueled by a positive feedback loop initiated by ligand binding. Antagonizing binding of physiological ligands to RAGE, therefore, is our target for down-regulation of the pathophysiological changes brought about by excessive concentrations of AGEs and other ligands for RAGE.

Thus, there is a need for the development of compounds that antagonize binding of physiological ligands to the RAGE receptor.

›SUMMARY OF THE INVENTION

This invention provides substituted benzimidazole compounds. Embodiments of the present invention provide compounds of Formula (I) as depicted below, methods of their preparation, pharmaceutical compositions comprising the compounds, and methods for their use in treating human or animal disorders. Compounds of the invention are useful as modulators of the interaction of the receptor for advanced glycated end products (RAGE) with its ligands such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin. The compounds are useful in a variety of applications including the management, treatment, control, and/or as an adjunct of diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

›DETAILED DESCRIPTION OF THE INVENTION · 1 of 5

In a first aspect, the present invention provides certain substituted azole compounds. Such compounds are useful in the modulation, preferably in the inhibition, of the interaction of RAGE with its physiological ligands, as will be discussed in more detail below.

In a second aspect, the present invention provides compounds of Formula (I):

wherein

R 1 comprises -hydrogen, -aryl, -heteroaryl, -cycloalkyl, -heterocyclyl, -alkyl, -alkenyl, -alkynyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, -fused cycloalkylaryl, -fused cycloalkylheteroaryl, -fused heterocyclylaryl, -fused heterocyclylheteroaryl, -alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, -alkylene-fused heterocyclylheteroaryl, or -G 1 -G 2 -G 3 -R 5 wherein

G 1 and G 3 independently comprise alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, (aryl)alkylene, (heteroaryl) alkylene, (aryl)alkenylene, (heteroaryl)alkenylene, or a direct bond; G 2 comprises —O—, —S—, —S(O)—, —N(R 6 )—, —S(O) 2 —, —C(O)—, —O—C(O)—, —C(O)—O—, —C(O)N(R 6 )—, —N(R 6 )C(O)—, —S(O 2 )N(R 6 )—, N(R 6 )S(O 2 )—, —O-alkylene-C(O)—, —(O)C-alkylene-O—, —O-alkylene-, -alkylene-O—, alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, fused cycloalkylarylene, fused cycloalkylheteroarylene, fused heterocyclylarylene, fused heterocyclylheteroarylene, or a direct bond, wherein R 6 comprises hydrogen, aryl, alkyl, -alkylene-aryl, alkoxy, or -alkylene-O-aryl; and R 5 comprises hydrogen, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, -alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, or -alkylene-fused heterocyclylheteroaryl;

A 1 comprises O, S, or —N(R 2 )—; wherein

R 2 comprises a) —H; b) -aryl; c) -heteroaryl; d) -cycloalkyl e) heterocyclyl; f) -alkyl; g) -alkenyl; h) -alkynyl; i) -alkylene-aryl, j) -alkylene-heteroaryl, k) -alkylene-heterocyclyl, l) -alkylene-cycloalkyl; m) -fused cycloalkylaryl, n) -fused cycloalkylheteroaryl, o) -fused heterocyclylaryl, p) -fused heterocyclylheteroaryl; q) -alkylene-fused cycloalkylaryl, r) -alkylene-fused cycloalkylheteroaryl, s) -alkylene-fused heterocyclylaryl, t) -alkylene-fused heterocyclylheteroaryl; or u) a group of the formula

R 3 and R 4 independently comprise

a) -hydrogen,

b) -halogen,

c) -hydroxyl,

d) -cyano,

e) -carbamoyl,

f) -carboxyl,

g) -aryl,

h) -heteroaryl,

i) -cycloalkyl,

j) -heterocyclyl,

k) -alkyl,

l) -alkenyl,

m) -alkynyl,

n) -alkylene-aryl,

o) -alkylene-heteroaryl,

p) -alkylene-heterocyclyl,

q) -alkylene-cycloalkyl,

r) -fused cycloalkylaryl,

s) -fused cycloalkylheteroaryl,

t) -fused heterocyclylaryl,

u) -fused heterocyclylheteroaryl,

v) -alkylene-fused cycloalkylaryl,

w) -alkylene-fused cycloalkylheteroaryl,

x) -alkylene-fused heterocyclylaryl,

y) -alkylene-fused heterocyclylheteroaryl;

z) —C(O)—O-alkyl;

aa) —C(O)—O-alkylene-aryl;

bb) —C(O)—NH-alkyl;

cc) —C(O)—NH-alkylene-aryl;

dd) —SO 2 -alkyl;

ee) —SO 2 -alkylene-aryl;

ff) —SO 2 -aryl;

gg) —SO 2 —NH-alkyl;

hh) —SO 2 —NH-alkylene-aryl;

ii) —C(O)-alkyl;

jj) —C(O)-alkylene-aryl;

kk) -G 4 -G 5 -G 6 -R 7 ;

ll) —Y 1 -alkyl;

mm) —Y 1 -aryl;

nn) —Y 1 -heteroaryl;

oo) —Y 1 -alkylene-aryl;

pp) —Y 1 -alkylene-heteroaryl;

qq) —Y 1 -alkylene-NR 9 R 10 ; or

rr) —Y 1 -alkylene-W 1 -R 11 ;

wherein G 4 and G 6 independently comprise alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, (aryl)alkylene, (heteroaryl)alkylene, (aryl)alkenylene, (heteroaryl)alkenylene, or a direct bond; G 5 comprises —O—, —S—, —N(R 8 )—, —S(O)—, —S(O) 2 —, —C(O)—, —O—C(O)—, —C(O)—O—, —C(O)N(R 8 )—, N(R 8 )C(O)—, —S(O 2 )N(R 8 )—, N(R 8 )S(O 2 )—, —O-alkylene-C(O)—, —(O)C-alkylene-O—, —O-alkylene-, -alkylene-O—, alkylene, alkenylene, alkynylene, cycloalkylene, heterocy ylene, arylene, heteroarylene, fused cycloalkylarylene, fused cycloalkylheteroarylene, fused heterocyclylarylene, fused heterocyclylheteroarylene, or a direct bond, wherein R 8 comprises -hydrogen, -aryl, -alkyl, -alkylene-aryl, or -alkylene-O-aryl; R 7 comprises hydrogen, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, or -alkylene-fused heterocyclylheteroaryl; Y 1 and W 1 independently comprise —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

wherein R 12 and R 13 independently comprise aryl, alkyl,-alkylene-aryl, alkoxy, or -alkylene-O-aryl; and

R 9 , R 10 , and R 11 independently comprise aryl, heteroaryl, alkyl, -alkylene-heteroaryl, or -alkylene-aryl; and R 9 and R 10 may be taken together to form a ring having the formula —(CH 2 ) o —X 1 —(CH 2 ) p — bonded to the nitrogen atom to which R 9 and R 10 are attached,

wherein

o and p are, independently, 1, 2, 3, or 4; and X 1 comprises a direct bond, —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,

wherein R 14 and R 15 independently hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl;

wherein

the aryl and/or alkyl group(s) in R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , and R 15 may be optionally substituted 1-4 times with a substituent group, wherein said substituent group(s) or the term substituted refers to a group comprising:

a) —H,

b) -halogen,

c) -hydroxyl,

d) -cyano,

e) -carbamoyl,

f) -carboxyl,

g) —Y 2 -alkyl;

h) —Y 2 -aryl;

i) —Y 2 -heteroaryl;

›DETAILED DESCRIPTION OF THE INVENTION · 2 of 5

j) —Y 2 -alkylene-heteroarylaryl;

k) —Y 2 -alkylene-aryl;

l) —Y 2 -alkylene-W 2 —R 18 ;

m) —Y 3 —Y 4 —NR 23 R 24 ,

n) —Y 3 —Y 4 —NH—C(═NR 25 )NR 23 R 24 ,

o) —Y 3 —Y 4 —C(═NR 25 )NR 23 R 24 , or

p) —Y 3 —Y 4 —Y 5 -A 2 ,

wherein Y 2 and W 2 independently comprise —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—S(O) 2 —, —O—CO—,

wherein

either

at least one of the groups R 1 , R 2 , R 3 and R 4 are substituted with at least one group of the formula —Y 3 —Y 4 —NR 23 R 24 , —Y 3 —Y 4 —NH—C(═NR 25 )NR 23 R 24 , —Y 3 —Y 4 —C(═NR 25 )NR 23 R 24 , or —Y 3 —Y 4 —Y 5 -A 2 , with the proviso that no more than one of R 23 , R 24 , and R 25 may comprise aryl or heteroaryl; or

R 2 is a group of the formula

wherein

one of R 3 and R 4 , R 3 and R 2 , or R 1 and R 2 may be taken together to constitute, together with the atoms to which they are bonded, an aryl, heteroaryl, fused arylcycloalkyl, fused arylheterocyclyl, fused heteroarylcycloalkyl, or fused heteroarylheterocyclyl ring system, wherein

said ring system or R 1 , R 2 , R 3 , or R 4 is substituted with at least one group of the formula

a) —Y 5 —Y 6 —NR 33 R 34 ; b) —Y 5 —Y 6 —NH—C(═NR 35 )NR 33 R 34 ; c) —Y 5 —Y 6 —C(═NR 35 )NR 33 R 34 ; or d) —Y 5 —Y 6 —Y 7 -A 4 ; wherein

Y 5 and Y 7 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

or a pharmaceutically acceptable salt thereof.

In a preferred embodiment, the compound of Formula (I) comprises a compound of the Formula (Ia)

wherein

R 1 comprises -hydrogen, -aryl, -heteroaryl, -cycloalkyl, -heterocyclyl, -alkyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, or -G 1 -G 2 -G 3 -R 5 wherein

G 1 and G 3 independently comprise alkylene or a direct bond; G 2 comprises —O—, —CO 2 —, or a direct bond; and R 5 comprises hydrogen, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, or -alkylene-cycloalkyl.

R 2 comprises a) -hydrogen, b) -aryl, c) -heteroaryl, d) -heterocyclyl, e) -alkyl, f) -alkylene-aryl, g) -alkylene-heteroaryl, h) -alkylene-heterocyclyl, i) -fused cycloalkylaryl, j) -fused cycloalkylheteroaryl, k) -fused heterocyclylaryl, l) -fused heterocyclylheteroaryl; m) -alkylene-fused cycloalkylaryl, n) -alkylene-fused cycloalkylheteroaryl, o) -alkylene-fused heterocyclylaryl, p) -alkylene-fused heterocyclylheteroaryl; or q) a group of the formula

R 3 and R 4 independently comprise

a) -hydrogen;

b) -halogen,

c) -hydroxyl,

d) -cyano,

e) -carbamoyl,

f) -carboxyl;

g) -aryl,

h) -heteroaryl,

i) -cycloalkyl,

j) -heterocyclyl,

k) -alkyl,

l) -alkenyl,

m) -alkynyl,

n) -alkylene-aryl,

o) -alkylene-heteroaryl,

p) -alkylene-heterocyclyl,

q) -alkylene-cycloalkyl,

r) -fused cycloalkylaryl,

s) -fused cycloalkylheteroaryl,

t) -fused heterocyclylaryl,

u) -fused heterocyclylheteroaryl,

v) -alkylene-fused cycloalkylaryl,

w) -alkylene-fused cycloalkylheteroaryl,

x) -alkylene-fused heterocyclylaryl,

y) -alkylene-fused heterocyclylheteroaryl;

z) —C(O)—O-alkyl;

aa) —C(O)—O-alkylene-aryl;

bb) —C(O)—NH-alkyl;

cc) —C(O)—NH-alkylene-aryl;

dd) —SO 2 -alkyl;

ee) —SO 2 -alkylene-aryl;

ff) —SO 2 -aryl;

gg) —SO 2 —NH-alkyl;

hh) —SO 2 —NH-alkylene-aryl

ii) —C(O)-alkyl;

jj) —C(O)-alkylene-aryl;

kk) -G 4 -G 5 -G 6 -R 7

ll) —Y 1 -alkyl;

mm) —Y 1 -aryl;

nn) —Y 1 -heteroaryl;

oo) —Y 1 -alkylene-aryl;

pp) —Y 1 -alkylene-heteroaryl;

qq)-Y 1 -alkylene-NR 9 R 10 ; and

rr) —Y 1 -alkylene-W 1 —R 11 ;

wherein G 4 and G 6 independently comprise alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, (arylalkylene, (heteroary) alkylene, (aryl)alkenylene, (heteroaryl)alkenylene, or a direct bond; G 5 comprises —O—, —S—, —N(R 8 )—, —S(O)—, —S(O) 2 —, —C(O)—, —C(O)N(R 8 )—, N(R 8 )C(O)—, —S(O 2 )N(R 8 )—, N(R 8 )S(O 2 )—, —O-alkylene-C(O)—, —(O)C-alkylene-O—, —O-alkylene-, -alkylene-O—, alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, or a direct bond, wherein R 8 comprises -hydrogen, -aryl, -alkyl, -alkylene-aryl, or -alkylene-O-aryl; R 7 comprises hydrogen; aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, or -alkylene-fused heterocyclylheteroaryl; Y 1 and W 1 independently comprise —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

wherein R 12 and R 13 independently comprise aryl, alkyl,-alkylene-aryl, alkoxy, or -alkylene-O-aryl;

wherein

o and p are, independently, 1, 2, 3, or 4; X 1 comprises a direct bond, —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,

with the proviso that R 3 and R 4 can not both be hydrogen.

In one group of preferred embodiments of Formula (Ia), R 1 comprises a hydrogen, methyl, ethyl, propyl, butyl, iso-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 3-butenyl, tert-butyl, 3-cyclohexyl-propyl, 3-phenoxy-propyl, methoxymethyl, 4-fluoro-phenyl, 3-(4-chlorophenoxy)-propyl, 2,4,4-trimethyl-pentyl, 1-ethyl-propyl, 1-propyl-butyl, benzyloxymethyl, 2-cyclopropy-ethyl, 2-phenyl-ethyl, 4-tert-butylphenoxymethyl, 4-tert-butylcyclohexyl, 4-butylcyclohexyl, 4-ethylcyclohexyl, 3-methoxycarbonyl-1-propyl, or 2-(pyridin-3-yl)-ethyl group.

›DETAILED DESCRIPTION OF THE INVENTION · 3 of 5

In another group of preferred embodiments of Formula (Ia), R 2 comprises a phenyl or 1,2,3,4-tetrahydroisoquinoline group, wherein the phenyl group is substituted with at least one substitutent comprising

a) —Y 2 -alkyl; b) —Y 2 -aryl; c) —Y 2 -heteroaryl; d) —Y 2 -alkylene-heteroarylaryl; e) —Y 2 -alkylene-aryl; f) —Y 2 -alkylene-W 2 —R 18 ; g) —Y 3 —Y 4 —NR 23 R 24 ; h) —Y 3 —Y 4 —NH—C(═NR 25 )NR 23 R 24 ; i) —Y 3 —Y 4 —C(═NR 25 )NR 23 R 24 ; or j) —Y 3 —Y 4 —Y 5 -A 2 ; wherein

Y 2 and W 2 independently comprise —CH 2 — or —O—, and R 18 comprises aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, or -alkylene-O-aryl; Y 3 and Y 5 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

In another group of preferred embodiments of compounds of Formula (Ia), R 2 comprises 4-[3-(N,N′-diethylamino)-propoxy]-phenyl, 4-[3-(N,N′-dimethylamino)-propoxy]-phenyl, 3-[3-(N,N′-diethylamino)-propoxy]-phenyl, 4-(3-fluoro-4-trifluoromethyl-phenoxy)-phenyl, 4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl, 4-(4-trifluoromethoxy-phenoxy)-phenyl, 4-(3,4-dichloro-phenoxy)-phenyl, 4-(3,5-bis-trifluoromethyl-phenoxy)-phenyl, 4-benzyloxy-phenyl, 4-(4-methyloxy-phenoxy)-phenyl, 4-(2-hexyl-4-chloro-phenoxy)-phenyl, 4-(4-phenyl-phenoxy)-phenyl, 4-(4-acetamido-phenoxy)-phenyl, 4-(4-methyl-phenoxy)-phenyl, 4-(4-fluoro-phenoxy)-phenyl, 4-(4-bromo-phenoxy)-phenyl, 4-(4-chloro-phenoxy)-phenyl, 4-(4-amino-phenoxy)-phenyl, 4-(3-ethyl-4-chloro-phenoxy)-phenyl, 4-[2-(N-ethylamino)-ethoxy]-phenyl, 4-[2,2′-dimethyl-3-(N,N′-dimethylamino)-propoxy]-phenyl, 1,2,3,4-tetrahydroisoquinolin-7-yl, 4-(4-benzamido-phenoxy)-phenyl, 4-(4-isonicotinamido-phenoxy)-phenyl, 4-[2-(N-methyl-N′-pyrid-4-yl)-ethoxy]-phenyl, 4-[3-(diethylmethyl ammonium)-propoxy)]-phenyl, 4-(2,5-di-fluoro-benzyloxy)-phenyl, 4-(2,4-dichloro-phenoxy)-phenyl, 4-(naphthalen-2-yloxy)-phenyl, 4-(6-methoxy-naphthalen-2-yloxy)-phenyl, 4-(4-methoxy-naphthalen-2-yloxy)-phenyl, 4-(6-hydroxy-naphthalen-2-yloxy)-phenyl, 4-(dibenzofuran-2-yloxy)-phenyl, 4-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl, 4-[2-(piperazin-1-yl)-ethoxy]-phenyl, or 4-(4-tert-butyl-phenoxy)-phenyl.

In another group of preferred embodiments of Formula (Ia), R 3 comprises hydrogen; and R 4 comprises a phenyl group, wherein the phenyl group is substituted with at least one substituent comprising

Y 2 and W 2 independently comprise —CH 2 — or —O—; R 18 comprises aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, or alkylene-O-aryl; Y 3 and Y 5 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

In a more preferred group of compounds of Formula (Ia), R 3 comprises hydrogen and R 4 comprises 4-{2-[(4-chlorophenyl)-ethoxy]}-phenyl, 4-[3-(N,N′-diethylamino)-propoxy]-phenyl, 4-(2-amino-ethoxy)-phenyl, 4-[2-(N-methyl-N′-pyridin-4-yl-amino)-ethoxy]-phenyl, 4-[2-(N-ethyl-N′-pyridin-4-yl-amino)-ethoxy]-phenyl, 4-[2-(N-pyridin-4-yl-amino)-ethoxy]-phenyl, 4-(4-amino-pyridin-3-yl-oxy)-phenyl, 4-[(pyridin-4-yl)-amino]-phenyl, 4-[2-(N,N′-bis-pyridin-2-ylmethyl-amino)-ethoxy]-phenyl, 4-[2-(guanidinyl)-ethoxy]-phenyl, 4-{2-[4-(pyridin-4-yl)-piperazin-1-yl]-2-oxo-ethoxy}-phenyl, 4-[2-(N-methyl-N′-3-methylpyridin-4-yl-amino)-ethoxy]-phenyl, 4-(4-hydroxy-pyrrolidin-2-ylmethyloxy)-phenyl, 4-(4-amino-3,5-dimethyl-pyrrolidin-2-ylmethyloxy)-phenyl, dibenzofuran-2-yl, 4-[3-(piperazin-1-yl)-propoxy]-phenyl, 4-(piperazin-4-yloxy)-phenyl, 4-[5-(piperazin-1-yl)-pentoxy]-phenyl, 4-[3-(N,N′-dimethylamino)-propoxy]-phenyl, 4-(3-fluoro-4-trifluoromethyl-phenoxy)-phenyl, 4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl, 4-(4-phenyl-phenoxy)-phenyl, 4-(3-trifluoromethoxy-phenoxy)-phenyl, 4-(4-trifluoromethyl-benzyloxy)-phenyl, 4-(3,4-dichloro-phenoxy)-phenyl, 4-(2,4-dichloro-phenoxy)-phenyl, 4-(1-ethyl-piperidin-3-yloxy)-phenyl, 4-benzyloxy-phenyl, 4-[(1-ethyl-piperidin-3-yl)-methoxy]-phenyl, 4-(4-phenoxy-benzyloxy)-phenyl, 4-(4-benzyloxy-benzyloxy)-phenyl, 4-(2-benzenesulfonylmethyl-benzyloxy)-phenyl, 4-(3,4,5-trimethoxybenzyloxy)-phenyl, 4-[2-(pyrrolidin-1-yl)-ethoxy]-phenyl, 4-[2-(piperidin-1-yl)-ethoxy]-phenyl, 4-[2,2′-dimethyl-3-(N,N′-dimethylamino)-propoxy]-phenyl, 4-[2-(N,N′-diisopropylamino)-ethoxy]-phenyl, 4-(adamantan-1-ylmethoxy)-phenyl, 3-[(2,6-dichlorophenyl)-4-methyl-isoxazol-5-ylmethyloxy]-phenyl, 4-(4-bromo-benzyloxy)-phenyl, 4-(4-chlorophenoxy)-phenyl, 4-[4-{(1-ethyl-piperidin-4-yl)-methylamino}-phenoxy]-phenyl, 4-(3,3-diphenylpropoxy)-phenyl, 4-[3,3-Bis-(4-fluorophenyl)-propoxy]-phenyl, 4-[3,3-Bis-(4-chlorophenyl)-allyoxy]-phenyl, 4-(4-chlorophenoxy)-naphthalenyl, 4-[2-(biphenyl-4-yl)-acetamido]-phenyl, 4-(2-(9H-carbazole)-ethoxy]-phenyl, 4-[4-methoxyphenyoxy]-phenyl, 4-(4-tert-butyl-phenoxy)-phenyl, or 4-(naphthylen-2-ylmethoxy)-phenyl.

In another preferred embodiment, the compound Formula (I) comprises the compound of Formula (Ib),

wherein

R 1 comprises -hydrogen, -aryl, -heteroaryl, -cycloalkyl, -heterocyclyl, -alkyl, -alkenyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, -fused cycloalkylaryl, -fused cycloalkylheteroaryl, -fused heterocyclylaryl, -fused heterocyclylheteroaryl, -alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, -alkylene-fused heterocyclylheteroaryl, or -G 1 -G 2 -G 3 -R 5 wherein

G 1 and G 3 independently comprise alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, (aryl)alkylene, (heteroaryl) alkylene, (aryl)alkenylene, (heteroaryl)alkenylene, or a direct bond; G 2 comprises —O—, —S—, —S(O)—, —N(R 6 )—, —S(O) 2 —, —C(O)—, —CO 2 —, —C(O)N(R 6 )—, N(R 6 )C(O)—, —S(O 2 )N(R 6 )—, N(R 6 )S(O 2 )—, —O-alkylene-C(O)—, —(O)C-alkylene-O—, —O-alkylene-, -alkylene-O—, alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, or a direct bond, wherein R 6 comprises hydrogen, aryl, alkyl, -alkylene-aryl, alkoxy, or -alkylene-O-aryl; and R 5 comprises hydrogen, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl; alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, or -alkylene-fused heterocyclylheteroaryl;

›DETAILED DESCRIPTION OF THE INVENTION · 4 of 5

R 3 comprises hydrogen or an alkyl group; and R 102 and R 104 independently comprise a) —H; b) -alkyl; c) -aryl; d) -heteroaryl; e) -alkylene-heteroarylaryl; f) -alkylene-aryl; g) -alkylene-W 2 —R 18 ; h) —Y 4 —NR 23 R 24 ; i) —Y 4 —NH—C(═NR 25 )NR 23 R 24 ; j) —Y 4 —C(═NR 25 )NR 23 R 24 ; or k) —Y 4 —Y 5 -A 2 ;

wherein W 2 comprises —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—S(O) 2 —, —O—CO—,

wherein said alkylene groups may optionally contain one or more O, S, S(O), or SO 2 atoms;

A 2 comprises

a) heterocyclyl, fused arylheterocyclyl, or fused heteroarylheterocyclyl, containing at least one basic nitrogen atom, b) -imidazolyl, or c) -pyridyl;

R 23 , R 24 , and R 25 independently comprise hydrogen, aryl, heteroaryl, -alkylene-heteroaryl, alkyl, -alkylene-aryl, -alkylene-O-aryl, or -alkylene-O-heteroaryl; and R 23 and R 24 may be taken together to form a ring having the formula —(CH 2 ) s —X 3 —(CH 2 ) t — bonded to the nitrogen atom to which R 23 and R 24 are attached

wherein

s and t are, independently, 1, 2, 3, or 4; X 3 comprises direct bond, —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,

wherein R 28 and R 29 independently comprise hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl;

wherein

the alkyl and/or aryl groups of R 102 and R 104 may be optionally substituted 1-4 times with a substituent group, wherein said substituent group(s) or the term substituted refers to a group comprising:

a) halogen; b) perhaloalkyl; c) alkyl; d) cyano; e) alkyloxy; f) aryl; or g) aryloxy.

In a group of preferred embodiments of the compound of Formula (Ib), R 1 comprises a hydrogen, methyl, ethyl, propyl, butyl, iso-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 3-butenyl, tert-butyl, 3-cyclohexyl-propyl, 3-phenoxy-propyl, methoxymethyl, 4-fluoro-phenyl, 3-(4-chlorophenoxy)-propyl, 2,4,4-trimethyl-pentyl, 1-ethyl-propyl, 1-propyl-butyl, benzyloxymethyl, 2-cyclopropy-ethyl, 2-phenyl-ethyl, 4-tert-butylphenoxymethyl, 4-tert-butylcyclohexyl, 4-ethylcyclohexyl, 4-butylcyclohexyl, 3-methoxycarbonyl-1-propyl, or 2-(pyridin-3-yl)-ethyl group, and R 3 comprises hydrogen.

In another group of preferred embodiments of the compound of Formula (Ib), R 102 and R 104 independently comprise 2-(4-chlorophenyl)-ethyl, 3-(N,N′-diethylamino)-propyl, 2-amino-ethyl, 2-(N-methyl-N′-pyridin-4-yl-amino)-ethyl, 2-(N-ethyl-N′-pyridin-4-yl-amino)-ethyl, 2-(N-pyridin-4-yl-amino)-ethoxy, 4-(4-amino-pyridin-3-yl-oxy), 4-(pyridin-4-yl)-amino, 2-(N,N′-bis-pyridin-2-ylmethyl-amino)-ethyl, 2-(guanidinyl)-ethyl, 2-[4-(pyridin-4-yl)-piperazin-1-yl]-2-oxo-ethyl, 2-(N-methyl-N′-3-methylpyridin-4-yl-amino)-ethyl, 4-hydroxy-pyrrolidin-2-ylmethyl, 4-amino-3,5-dimethyl-pyrrolidin-2-ylmethyl, dibenzofuran-2-yl, 3-(piperazin-1-yl)-propyl, piperazin-4-yl, 5-(piperazin-1-yl)-pentyl, 3-(N,N′-dimethylamino)-propyl, 3-fluoro-4-trifluoromethyl-phenyl, 4-fluoro-3-trifluoromethyl-phenyl, 4-phenyl-phenyl, 3-trifluoromethoxy-phenyl, 4-trifluoromethyl-benzyl, 3,4-dichloro-phenyl, 2,4-dichloro-phenyl, 1-ethyl-piperidin-3-yl, benzyl, (1-ethyl-piperidin-3-yl)-methyl, 4-phenoxy-benzyl, 4-benzyloxy-benzyl, 2-benzenesulfonylmethyl-benzyl, 3,4,5-trimethoxybenzyl, 2-(pyrrolidin-1-yl)-ethyl, 2-(piperidin-1-yl)-ethyl, 2,2′-dimethyl-3-(N,N′-dimethylamino)-propyl, 2-(N,N′-diisopropylamino)-ethyl, 3-(2,6-dichlorophenyl)-4-methyl-isoxazol-5-ylmethyl, 4-bromo-benzyl, 4-chlorophenyl, 4-{(1-ethyl-piperidin-4-yl)-methylamino}-phenyl, 3,3-diphenylpropyl, 3,3-Bis-(4-fluorophenyl)-propyl, 3,3-Bis-(4-chlorophenyl)-allyl, 4-(4-chlorophenoxy)-naphthalenyl, 4-[2-(biphenyl-4-yl)-acetamido]-phenyl, 2-(9H-carbazole)-ethyl, 4-methoxyphenyl, 4-tert-butyl-phenyl, or naphthylen-2-ylmethyl.

In another group of preferred embodiments of the compound of Formula (Ib), R 1 comprises -alkyl, -alkylene-cycloalkylene-alkyl, -cycloalkyl, -heterocyclyl, -alkylene-cycloalkyl, -alkylene-heteroaryl, -alkylene-heterocyclyl, or -alkylene-heterocyclylene-alkyl; R 3 comprises hydrogen; R 102 comprises -aryl or -alkylene-aryl substituted with at least one of a halogen, a perhaloalkyl, or an alkoxy group; and R 104 comprises —Y 4 —NR 23 R 24 or —Y 4 —Y 5 -A 2 .

In another group of preferred embodiments of the compound of Formula (Ib), R 1 comprises -heterocyclyl, heterocyclylene-heteroaryl, -alkylene-cycloalkyl, -alkylene-heteroaryl, -alkylene-heterocyclyl, or -alkylene-heterocyclylene-alkyl; R 3 comprises hydrogen; and R 102 and R 104 independently comprise -aryl or -alkylene-aryl, wherein the alkyl or ary groups are optionally substituted with at least one of a halogen, a perhaloalkyl, or an alkoxy group, and wherein at least one of R 102 and R 104 comprise —Y 4 —NR 23 R 24 or —Y 4 —Y 5 -A 2 , wherein Y 4 comprises alkylene.

In a preferred embodiment, the compound of Formula (I) comprises a compound of the Formula (Ic)

wherein

G 1 and G 3 independently comprise alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, (aryl)alkylene, (heteroaryl) alkylene, (aryl)alkenylene, (heteroaryl)alkenylene, or a direct bond; G 2 comprises —O—, —S—, —S(O)—, —N(R 6 )—, —S(O) 2 —, —C(O)—, —CO 2 —, —C(O)N(R 6 )—, N(R 6 )C(O)—, —S(O 2 )N(R 6 )—, N(R 6 )S(O 2 )—, —O-alkylene-C(O)—, —(O)C-alkylene-O—, —O-alkylene-, -alkylene-O—, alkylene, alkenylene, alkynylene, cycloalkylene, heterocyclylene, arylene, heteroarylene, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl, or a direct bond, wherein R 6 comprises hydrogen, aryl, alkyl, -alkylene-aryl, alkoxy, or -alkylene-O-aryl; and R 5 comprises hydrogen, aryl, heteroaryl, cycloalkyl, heterocyclyl, alkyl, alkenyl, alkynyl, -alkylene-aryl, -alkylene-heteroaryl, -alkylene-heterocyclyl, -alkylene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclylheteroaryl; -alkylene-fused cycloalkylaryl, -alkylene-fused cycloalkylheteroaryl, -alkylene-fused heterocyclylaryl, or -alkylene-fused heterocyclylheteroaryl;

›DETAILED DESCRIPTION OF THE INVENTION · 5 of 5

R 2 comprises a) -hydrogen, b) -aryl, c) -heteroaryl, d) -cycloalkyl, e) -heterocyclyl; f) -alkyl, g) -alkenyl, h) -alkynyl, i) -alkylene-aryl, j) -alkylene-heteroaryl, k) -alkylene-heterocyclyl, l) -alkylene-cycloalkyl; m) fused cycloalkylaryl, n) fused cycloalkylheteroaryl, o) fused heterocyclylaryl, p) fused heterocyclylheteroaryl; q) -alkylene-fused cycloalkylaryl, r) -alkylene-fused cycloalkylheteroaryl, s) -alkylene-fused heterocyclylaryl, or t) -alkylene-fused heterocyclylheteroaryl, R 111 , R 112 , R 113 and R 114 independently comprise a) -hydrogen, b) -halogen, c) -hydroxyl, d) -cyano, e) -carbamoyl, f) -carboxyl, g) —Y 8 -alkyl, h) —Y 8 -aryl, i) —Y 8 -heteroaryl, j) —Y 8 -alkylene-aryl, k) —Y 8 -alkylene-heteroaryl, l) —Y 8 -alkylene-W 3 —R 40 , m) —Y 5 —Y 6 —NR 33 R 34 , n) —Y 5 —Y 6 —NH—C(═NR 35 )NR 33 R 34 , o) —Y 5 —Y 6 —C(═NR 35 )NR 33 R 34 , or p) —Y 5 —Y 6 —Y 7 -A 4 ;

wherein Y 5 and Y 7 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, C(O)—O—, —NHSO 2 NH—, —O—CO—,

wherein at least one of R 111 , R 112 , R 113 , and R 114 comprise a group of the formula —Y 5 —Y 6 —NR 33 R 34 , —Y 5 —Y 6 —NH—C(═NR 35 )NR 33 R 34 , —Y 5 —Y 6 —C(═NR 35 )NR 33 R 34 , or —Y 5 —Y 6 —Y 7 -A 4 .

In one group of preferred embodiments of the compound of Formula (Ic), R 2 comprises hydrogen or alkyl.

In another group of preferred embodiments of the compound of Formula (Ic), R 1 comprises a phenyl group substituted by one or more substituents comprising

a) —Y 2 -alkyl; b) —Y 2 -aryl; c) —Y 2 -heteroaryl; d) —Y 2 -alkylene-heteroarylaryl; e) —Y 2 -alkylene-aryl; f) —Y 2 -alkylene-W 2 —R 18 ; g) —Y 3 —Y 4 —NR 23 R 24 h) —Y 3 —Y 4 —NH—C(═NR 25 )NR 23 R 24 i) —Y 3 —Y 4 —C(═NR 25 )NR 23 R 24 j) —Y 3 —Y 4 —Y 5 -A 2 wherein

Y 2 and W 2 independently comprise —CH 2 —, —O—, and R 18 comprises aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, or alkylene-O-aryl; Y 3 and Y 5 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

In another group of preferred embodiments of the compound of Formula (Ic), R 1 comprises 2-methoxy-3,5-dimethyoxy-phenyl, 3-(4-tert-butyl-phenoxy)-phenyl, 4-[3-(N,N′-diethylamino)-propoxy]-phenyl, 4-[3-(N,N′-dimethylamino)-propoxy]-phenyl, 4-[(pyrrolidin-1-yl)-ethoxy]-phenyl, 3-[(pyrrolidin-1-yl)-ethoxy]-phenyl, 2-[(pyrrolidin-1-yl)-ethoxy]-phenyl, 3-(naphthalen-2-yloxy)-phenyl, 4-biphenyl, 3-(3,3-dimethylbutoxy)-phenyl, 3-(phenoxy)-phenyl, 3-(3,4-dichloro-phenoxy)-phenyl, 3-(3,5-dichloro-phenoxy)-phenyl, 4-tert-butyl-phenyl, 4-(dibutylamino)-phenyl, 4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl, 2-naphthyl, 2-benzofuranyl, 3-(3-trifluoromethyl-phenoxy)-phenyl, 4-chloro-phenyl, 2-benzhydryl, 4-isopropoxy-phenyl, 3-(4-tertbutyl-phenoxy)-phenyl, 4-[2-(4-chloro-phenyl)-ethoxy]-phenyl, 3-[2-(4-chloro-phenyl)-ethoxy]-phenyl, 2-{3-[2-(4-chloro-phenyl)-ethoxy]-phenyl]-ethyl, 2-{4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl}-ethyl, or 2-[3-(N,N-diethylamino)-propoxy)]-4-[2-(4-chloro-phenyl)-ethoxy]-phenyl.

In another group of preferred embodiments of the compound of Formula (Ic), R 1 comprises 4-[2-(4-chloro-phenyl)-ethoxy]-phenyl, 3-[2-(4-chloro-phenyl)-ethoxy]-phenyl, 2-{3-[2-(4-chloro-phenyl)-ethoxy]-phenyl]-ethyl, 2-{4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl}-ethyl, or 2-[3-(N,N-diethylamino)-propoxy)]-4-[2-(4-chloro-phenyl)-ethoxy]-phenyl.

In another group of preferred embodiments of the compound of Formula (Ic), R 111 , R 112 and R 114 comprise hygrogen; and R 113 comprises —Y 3 —Y 4 —NR 23 R 24 , or —Y 3 —Y 4 —Y 5 -A 2 .

In the compounds of Formula (I), the various functional groups represented should be understood to have a point of attachment at the functional group having the hyphen. In other words, in the case of —C 1-6 alkylaryl, it should be understood that the point of attachment is the alkyl group; an example would be benzyl. In the case of a group such as —C(O)—NH—C 1-6 alkylaryl, the point of attachment is the carbonyl carbon.

Also included within the scope of the invention are the individual enantiomers of the compounds represented by Formula (I) above as well as any wholly or partially racemic mixtures thereof. The present invention also covers the individual enantiomers of the compounds represented by the Formula above as mixtures with diastereoisomers thereof in which one or more stereocenters are inverted.

Compounds of the present invention preferred for their high biological activity are listed by name below in Table 1.

›DEFINITIONS OF TERMS · 1 of 5

As used herein, the term “lower” refers to a group having between one and six carbons.

As used herein, the term “alkyl” refers to a straight or branched chain hydrocarbon having from one to ten carbon atoms, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkyl” group may containing one or more O, S, S(O), or S(O) 2 atoms. Examples of “alkyl” as used herein include, but are not limited to, methyl, n-butyl, t-butyl, n-pentyl, isobutyl, and isopropyl, and the like.

As used herein, the term “alkylene” refers to a straight or branched chain divalent hydrocarbon radical having from one to ten carbon atoms, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkylene” group may containing one or more O, S, S(O), or S(O) 2 atoms. Examples of “alkylene” as used herein include, but are not limited to, methylene, ethylene, and the like.

As used herein, the term “alkyline” refers to a straight or branched chain trivalent hydrocarbon radical having from one to ten carbon atoms, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Examples of “alkyline” as used herein include, but are not limited to, methine, 1,1,2-ethyline, and the like.

As used herein, the term “alkenyl” refers to a hydrocarbon radical having from two to ten carbons and at least one carbon-carbon double bond, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkenyl” group may containing one or more O, S, S(O), or S(O) 2 atoms.

As used herein, the term “alkenylene” refers to a straight or branched chain divalent hydrocarbon radical having from two to ten carbon atoms and one or more carbon-carbon double bonds, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkenylene” group may containing one or more O, S, S(O), or S(O) 2 atoms. Examples of “alkenylene” as used herein include, but are not limited to, ethene-1,2-diyl, propene-1,3-diyl, methylene-1,1-diyl, and the like.

As used herein, the term “alkynyl” refers to a hydrocarbon radical having from two to ten carbons and at least one carbon-carbon triple bond, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkynyl” group may containing one or more O, S, S(O), or S(O) 2 atoms.

As used herein, the term “alkynylene” refers to a straight or branched chain divalent hydrocarbon radical having from two to ten carbon atoms and one or more carbon-carbon triple bonds, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an “alkynylene” group may containing one or more O, S, S(O), or S(O) 2 atoms. Examples of “alkynylene” as used herein include, but are not limited to, ethyne-1,2-diyl, propyne-1,3-diyl, and the like.

›DEFINITIONS OF TERMS · 2 of 5

As used herein, “cycloalkyl” refers to an alicyclic hydrocarbon group optionally possessing one or more degrees of unsaturation, having from three to twelve carbon atoms, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. “Cycloalkyl” includes by way of example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or cyclooctyl, and the like.

As used herein, the term “cycloalkylene” refers to an non-aromatic alicyclic divalent hydrocarbon radical having from three to twelve carbon atoms and optionally possessing one or more degrees of unsaturation, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Examples of “cycloalkylene” as used herein include, but are not limited to, cyclopropyl-1,1-diyl, cyclopropyl-1,2-diyl, cyclobutyl-1,2-diyl, cyclopentyl-1,3-diyl, cyclohexyl-1,4-diyl, cycloheptyl-1,4-diyl, or cyclooctyl-1,5-diyl, and the like.

As used herein, the term “heterocyclic” or the term “heterocyclyl” refers to a three to twelve-membered heterocyclic ring optionally possessing one or more degrees of unsaturation, containing one or more heteroatomic substitutions selected from S, SO, SO 2 , O, or N, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such a ring may be optionally fused to one or more of another “heterocyclic” ring(s) or cycloalkyl ring(s). Examples of “heterocyclic” include, but are not limited to, tetrahydrofuran, 1,4-dioxane, 1,3-dioxane, piperidine, pyrrolidine, morpholine, piperazine, and the like.

As used herein, the term “heterocyclyl containing at least one basic nitrogen atom” refers to a “heterocyclic” “heterocyclyl” group as defined above, wherein said heterocyclyl group contains at least one nitrogen atom flanked by hydrogen, alkyl, alkylene, or alkylyne groups, wherein said alkyl and/or alkylene groups are not substituted by oxo. Examples of “heterocyclyl containing at least one basic nitrogen atom” include, but are not limited to, piperazine-2-yl, pyrrolidine-2-yl, azepine-4-yl,

and the like.

As used herein, the term “heterocyclylene” refers to a three to twelve-membered heterocyclic ring diradical optionally having one or more degrees of unsaturation containing one or more heteroatoms selected from S, SO, SO 2 , O, or N, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such a ring may be optionally fused to one or more benzene rings or to one or more of another “heterocyclic” rings or cycloalkyl rings. Examples of “heterocyclylene” include, but are not limited to, tetrahydrofuran-2,5-diyl, morpholine-2,3-diyl, pyran-2,4-diyl, 1,4-dioxane-2,3-diyl, 1,3-dioxane-2,4-diyl, piperidine-2,4-diyl, piperidine-1,4-diyl, pyrrolidine-1,3-diyl, morpholine-2,4-diyl, piperazine-1,4-diyl, and the like.

As used herein, the term “aryl” refers to a benzene ring or to an optionally substituted benzene ring system fused to one or more optionally substituted benzene rings, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy optionally substituted by acyl, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Examples of aryl include, but are not limited to, phenyl, 2-naphthyl, 1-naphthyl, 1-anthracenyl, and the like.

As used herein, the term “arylene” refers to a benzene ring diradical or to a benzene ring system diradical fused to one or more optionally substituted benzene rings, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Examples of “arylene” include, but are not limited to, benzene-1,4-diyl, naphthalene-1,8-diyl, and the like.

›DEFINITIONS OF TERMS · 3 of 5

As used herein, the term “heteroaryl” refers to a five- to seven-membered aromatic ring, or to a polycyclic heterocyclic aromatic ring, containing one or more nitrogen, oxygen, or sulfur heteroatoms, where N-oxides and sulfur monoxides and sulfur dioxides are permissible heteroaromatic substitutions, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. For polycyclic aromatic ring systems, one or more of the rings may contain one or more heteroatoms. Examples of “heteroaryl” used herein are furan, thiophene, pyrrole, imidazole, pyrazole, triazole, tetrazole, thiazole, oxazole, isoxazole, oxadiazole, thiadiazole, isothiazole, pyridine, pyridazine, pyrazine, pyrimidine, quinoline, isoquinoline, quinazoline, benzofuran, benzothiophene, indole, and indazole, and the like.

As used herein, the term “heteroarylene” refers to a five- to seven-membered aromatic ring diradical, or to a polycyclic heterocyclic aromatic ring diradical, containing one or more nitrogen, oxygen, or sulfur heteroatoms, where N-oxides and sulfur monoxides and sulfur dioxides are permissible heteroaromatic substitutions, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. For polycyclic aromatic ring system diradicals, one or more of the rings may contain one or more heteroatoms. Examples of “heteroarylene” used herein are furan-2,5-diyl, thiophene-2,4-diyl, 1,3,4-oxadiazole-2,5-diyl, 1,3,4-thiadiazole-2,5-diyl, 1,3-thiazole-2,4-diyl, 1,3-thiazole-2,5-diyl, pyridine-2,4-diyl, pyridine-2,3-diyl, pyridine-2,5-diyl, pyrimidine-2,4-diyl, quinoline-2,3-diyl, and the like.

As used herein, the term “fused cycloalkylaryl” refers to one or more cycloalkyl groups fused to an aryl group, the aryl and cycloalkyl groups having two atoms in common, and wherein the aryl group is the point of substitution. Examples of “fused cycloalkylaryl” used herein include 5-indanyl, 5,6,7,8-tetrahydro-2-naphthyl,

and the like.

As used herein, the term “fused cycloalkylarylene” refers to a fused cycloalkylaryl, wherein the aryl group is divalent. Examples include

and the like.

As used herein, the term “fused arylcycloalkyl” refers to one or more aryl groups fused to a cycloalkyl group, the cycloalkyl and aryl groups having two atoms in common, and wherein the cycloalkyl group is the point of substitution. Examples of “fused arylcycloalkyl” used herein include 1-indanyl, 2-indanyl, 9-fluorenyl, 1-(1,2,3,4-tetrahydronaphthyl),

and the like.

As used herein, the term “fused arylcycloalkylene” refers to a fused arylcycloalkyl, wherein the cycloalkyl group is divalent. Examples include 9,1-fluorenylene,

and the like.

As used herein, the term “fused heterocyclylaryl” refers to one or more heterocyclyl groups fused to an aryl group, the aryl and heterocyclyl groups having two atoms in common, and wherein the aryl group is the point of substitution. Examples of “fused heterocyclylaryl” used herein include 3,4-methylenedioxy-1-phenyl,

and the like

As used herein, the term “fused heterocyclylarylene” refers to a fused heterocyclylaryl, wherein the aryl group is divalent. Examples include

and the like.

As used herein, the term “fused arylheterocyclyl” refers to one or more aryl groups fused to a heterocyclyl group, the heterocyclyl and aryl groups having two atoms in common, and wherein the heterocyclyl group is the point of substitution. Examples of “fused arylheterocyclyl” used herein include 2-(1,3-benzodioxolyl),

and the like.

As used herein, the term “fused arylheterocyclyl containing at least one basic nitrogen atom” refers to a “fused arylheterocyclyl” group as defined above, wherein said heterocyclyl group contains at least one nitrogen atom flanked by hydrogen, alkyl, alkylene, or alkylyne groups, wherein said alkyl and/or alkylene groups are not substituted by oxo. Examples of “fused arylheterocyclyl containing at least one basic nitrogen atom” include, but are not limited to,

and the like.

As used herein, the term “fused arylheterocyclylene” refers to a fused arylheterocyclyl, wherein the heterocyclyl group is divalent. Examples include

and the like.

As used herein, the term “fused cycloalkylheteroaryl” refers to one or more cycloalkyl groups fused to a heteroaryl group, the heteroaryl and cycloalkyl groups having two atoms in common, and wherein the heteroaryl group is the point of substitution. Examples of “fused cycloalkylheteroaryl” used herein include 5-aza-6-indanyl,

and the like.

As used herein, the term “fused cycloalkylheteroarylene” refers to a fused cycloalkylheteroaryl, wherein the heteroaryl group is divalent. Examples include

and the like.

As used herein, the term “fused heteroarylcycloalkyl” refers to one or more heteroaryl groups fused to a cycloalkyl group, the cycloalkyl and heteroaryl groups having two atoms in common, and wherein the cycloalkyl group is the point of substitution. Examples of “fused heteroarylcycloalkyl” used herein include 5-aza-1-indanyl,

›DEFINITIONS OF TERMS · 4 of 5

and the like.

As used herein, the term “fused heteroarylcycloalkylene” refers to a fused heteroarylcycloalkyl, wherein the cycloalkyl group is divalent. Examples include

and the like.

As used herein, the term “fused heterocyclylheteroaryl” refers to one or more heterocyclyl groups fused to a heteroaryl group, the heteroaryl and heterocyclyl groups having two atoms in common, and wherein the heteroaryl group is the point of substitution. Examples of “fused heterocyclylheteroaryl” used herein include 1,2,3,4-tetrahydro-beta-carbolin-8-yl,

and the like.

As used herein, the term “fused heterocyclylheteroarylene” refers to a fused heterocyclylheteroaryl, wherein the heteroaryl group is divalent. Examples include

and the like.

As used herein, the term “fused heteroarylheterocyclyl” refers to one or more heteroaryl groups fused to a heterocyclyl group, the heterocyclyl and heteroaryl groups having two atoms in common, and wherein the heterocyclyl group is the point of substitution. Examples of “fused heteroarylheterocyclyl” used herein include -5-aza-2,3-dihydrobenzofuran-2-yl,

and the like.

As used herein, the term “fused heteroarylheterocyclyl containing at least one basic nitrogen atom” refers to a “fused heteroarylheterocyclyl” group as defined above, wherein said heterocyclyl group contains at least one nitrogen atom flanked by hydrogen, alkyl, alkylene, or alkylyne groups, wherein said alkyl and/or alkylene groups are not substituted by oxo. Examples of “fused heteroarylheterocyclyl containing at least one basic nitrogen atom” include, but are not limited to,

and the like.

As used herein, the term “fused heteroarylheterocyclylene” refers to a fused heteroarylheterocyclyl, wherein the heterocyclyl group is divalent. Examples include

and the like.

As used herein, the term “acid isostere” refers to a substituent group which will ionize at physiological pH to bear a net negative charge. Examples of such “acid isosteres” include but are not limited to heteroaryl groups such as but not limited to isoxazol-3-ol-5-yl, 1H-tetrazole-5-yl, or 2H-tetrazole-5-yl. Such acid isosteres include but are not limited to heterocyclyl groups such as but not limited to imidazolidine-2,4-dione-5-yl, imidazolidine-2,4-dione-1-yl, 1,3-thiazolidine-2,4-dione-5-yl, or 5-hydroxy-4H-pyran-4-on-2-yl.

As used herein, the term “direct bond”, where part of a structural variable specification, refers to the direct joining of the substituents flanking (preceding and succeeding) the variable taken as a “direct bond”. Where two or more consecutive variables are specified each as a “direct bond”, those substituents flanking (preceding and succeeding) those two or more consecutive specified “direct bonds” are directly joined.

As used herein, the term “alkoxy” refers to the group R a O—, where R a is alkyl.

As used herein, the term “alkenyloxy” refers to the group R a O—, where R a is alkenyl.

As used herein, the term “alkynyloxy” refers to the group R a O—, where R a is alkynyl.

As used herein, the term “alkylsulfanyl” refers to the group R a S—, where R a is alkyl.

As used herein, the term “alkenylsulfanyl” refers to the group R a S—, where R a is alkenyl.

As used herein, the term “alkynylsulfanyl” refers to the group R a S—, where R a is alkynyl.

As used herein, the term “alkylsulfenyl” refers to the group R a S(O)—, where R a is alkyl.

As used herein, the term “alkenylsulfenyl” refers to the group R a S(O)—, where R a is alkenyl.

As used herein, the term “alkynylsulfenyl” refers to the group R a S(O)—, where R a is alkynyl.

As used herein, the term “alkylsulfonyl” refers to the group R a SO 2 —, where R a is alkyl.

As used herein, the term “alkenylsulfonyl” refers to the group R a SO 2 —, where R a is alkenyl.

As used herein, the term “alkynylsulfonyl” refers to the group R a SO 2 —, where R a is alkynyl.

As used herein, the term “acyl” refers to the group R a C(O)—, where R a is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or heterocyclyl.

As used herein, the term “aroyl” refers to the group R a C(O)—, where R a is aryl.

As used herein, the term “heteroaroyl” refers to the group R a C(O)—, where R a is heteroaryl.

As used herein, the term “alkoxycarbonyl” refers to the group R a OC(O)—, where R a is alkyl.

As used herein, the term “acyloxy” refers to the group R a C(O)O—, where R a is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or heterocyclyl.

As used herein, the term “alkoxycarbonyl” refers to the group R a OC(O)—, where R a is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or heterocyclyl.

As used herein, the term “aryloxycarbonyl” refers to the group R a OC(O)—, where R a is aryl or heteroaryl.

As used herein, the term “aroyloxy” refers to the group R a C(O)O—, where R a is aryl.

As used herein, the term “heteroaroyloxy” refers to the group R a C(O)O—, where R a is heteroaryl.

As used herein, the term “optionally” means that the subsequently described event(s) may or may not occur, and includes both event(s) which occur and events that do not occur.

As used herein, the term “substituted” refers to substitution with the named substituent or substituents, multiple degrees of substitution being allowed unless otherwise stated.

As used herein, the terms “contain” or “containing” can refer to in-line substitutions at any position along the above defined alkyl, alkenyl, alkynyl or cycloalkyl substituents with one or more of any of O, S, SO, SO 2 , N, or N-alkyl, including, for example, —CH 2 —O—CH 2 —, —CH 2 —SO 2 —CH 2 —, —CH 2 —NH—CH 3 and so forth.

Whenever the terms “alkyl” or “aryl” or either of their prefix roots appear in a name of a substituent (e.g. arylalkoxyaryloxy) they shall be interpreted as including those limitations given above for “alkyl” and “aryl”. Alkyl or cycloalkyl substituents shall be recognized as being functionally equivalent to those having one or more degrees of unsaturation. Designated numbers of carbon atoms (e.g. C 1-10 ) shall refer independently to the number of carbon atoms in an alkyl, alkenyl or alkynyl or cyclic alkyl moiety or to the alkyl portion of a larger substituent in which the term “alkyl” appears as its prefix root.

›DEFINITIONS OF TERMS · 5 of 5

As used herein, the term “oxo” shall refer to the substituent ═O.

As used herein, the term “halogen” or “halo” shall include iodine, bromine, chlorine and fluorine.

As used herein, the term “mercapto” shall refer to the substituent —SH.

As used herein, the term “carboxy” shall refer to the substituent —COOH.

As used herein, the term “cyano” shall refer to the substituent —CN.

As used herein, the term “aminosulfonyl” shall refer to the substituent —SO 2 NH 2 .

As used herein, the term “carbamoyl” shall refer to the substituent —C(O)NH 2 .

As used herein, the term “sulfanyl” shall refer to the substituent —S—.

As used herein, the term “sulfenyl” shall refer to the substituent —S(O)—.

As used herein, the term “sulfonyl” shall refer to the substituent —S(O) 2 —.

As used herein, the term “solvate” is a complex of variable stoichiometry formed by a solute (in this invention, a compound of Formula (I)) and a solvent. Such solvents for the purpose of the invention may not interfere with the biological activity of the solute. Solvents may be, by way of example, water, ethanol, or acetic acid.

As used herein, the term “biohydrolyzable ester” is an ester of a drug substance (in this invention, a compound of Formula (I)) which either a) does not interfere with the biological activity of the parent substance but confers on that substance advantageous properties in vivo such as duration of action, onset of action, and the like, or b) is biologically inactive but is readily converted in vivo by the subject to the biologically active principle. The advantage is that, for example, the biohydrolyzable ester is orally absorbed from the gut and is transformed to (I) in plasma. Many examples of such are known in the art and include by way of example lower alkyl esters (e.g., C 1 -C 4 ), lower acyloxyalkyl esters, lower alkoxyacyloxyalkyl esters, alkoxyacyloxy esters, alkyl acylamino alkyl esters, and choline esters.

As used herein, the term “biohydrolyzable amide” is an amide of a drug substance (in this invention, a compound of general Formula (I)) which either a) does not interfere with the biological activity of the parent substance but confers on that substance advantageous properties in vivo such as duration of action, onset of action, and the like, or b) is biologically inactive but is readily converted in vivo by the subject to the biologically active principle. The advantage is that, for example, the biohydrolyzable amide is orally absorbed from the gut and is transformed to (I) in plasma. Many examples of such are known in the art and include by way of example lower alkyl amides, α-amino acid amides, alkoxyacyl amides, and alkylaminoalkylcarbonyl amides.

As used herein, the term “prodrug” includes biohydrolyzable amides and biohydrolyzable esters and also encompasses a) compounds in which the biohydrolyzable functionality in such a prodrug is encompassed in the compound of Formula (I): for example, the lactam formed by a carboxylic group in R 2 and an amine in R 4 , and b) compounds which may be oxidized or reduced biologically at a given functional group to yield drug substances of Formula (I). Examples of these functional groups include, but are not limited to, 1,4-dihydropyridine, N-alkylcarbonyl-1,4-dihydropyridine, 1,4-cyclohexadiene, tert-butyl, and the like.

The term “pharmacologically effective amount” or shall mean that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, animal or human that is being sought by a researcher or clinician. This amount can be a therapeutically effective amount. The term “therapeutically effective amount” shall mean that amount of a drug or pharmaceutical agent that will elicit the therapeutic response of an animal or human that is being sought.

The term “treatment” or “treating” as used herein, refers to the full spectrum of treatments for a given disorder from which the patient is suffering, including alleviation of one, most of all symptoms resulting from that disorder, to an outright cure for the particular disorder or prevention of the onset of the disorder.

The present invention also provides a method for the synthesis of compounds useful as intermediates in the preparation of compounds of Formula (I) along with methods for the preparation of compounds of Formula (I). Unless otherwise indicated, variables refer to those for Formula (I).

An aldehyde (1) (Scheme 1) may be condensed with a diamine compound (2) in a solvent such as ethanol at a temperature of from 25 to 100 degrees Celsius, to obtain the product benzimidazole (3), where the intermediate adduct undergoes spontaneous oxidation. Alternately, the acid (1a) may be coupled with the diamine compound (2) employing a reagent such as HBTU to afford (2a). The reaction may also afford some of the compound where the carboxylic acid has coupled to the secondary aniline nitrogen. Either product (2a) may be cyclized to (3). One nonlimiting method is to heat (2a) in a solvent such as acetic acid at a temperature of from 25 to 100 degrees Celsius, to obtain the cyclized product (3). Ar 1 is a group such as but not limited to an optionally substituted aryl or heteroaryl ring system.

Where R 52 is aryl, heteroaryl, or contains an aryl or heteroaryl group possessing a phenolic substituent, or where R 52 possesses a free hydroxyl group, an aldehyde of formula (4) (Scheme 2) may be treated with an optionally substituted alkyl halide R 51 -LG 1 and a base such as potassium carbonate, in a solvent such as DMF, at a temperature of from 0 to 120° C., to afford (5). LG 1 represents a nucleofugal group such as iodide, bromide, methanesulfonate, or toluenesulfonate (Scheme 2). Where R 53 in (6) represents an aryl or heteroaryl ring system, direct treatment of (6) in the presence of a base such as DIEA or TEA with an aryl or heteroaryl phenol Ar 2 —OH provides (7), where the Ar 2 —O— substituent is bonded to the same atom as the F in (6).

In Scheme 3, an aldehyde (8) possessing two free hydroxyl groups, two free phenolic groups, of a combination of phenolic and hydroxyl groups may be treated with two equivalents of an alkylating agent R 51 -LG 1 , in the presence of a suitable base such as potassium carbonate or DIEA, in a solvent such as DMF, to afford (9). Alternately, where R 53 is an aryl ring possessing ortho and para hydroxyl groups relative to the aldehyde group, treatment of (8) with one equivalent of base and an alkylating agent R 51 -LG 1 in the presence of a suitable base such as DIEA of potassium carbonate, followed by treatment with a second alkylating agent R 54 -LG 2 in the presence of base, affords (10). The ortho, para difluoro aldehyde (11), where R 53 is a heteroaryl or aryl ring, may be treated with an alcohol R 55 —OH in the presence of base such as DIEA, followed by treatment with a phenol Ar 3 —OH in the presence of a base such as DIEA or potassium carbonate, to afford (12).

›Scheme 4 describes the synthesis of substituted arylenediamines · 1 of 7

In Scheme 4, an ortho-fluoro nitrophenol such as (13) may be alkylated with an alkyl halide or other alkylating agent R 56 -LG 1 , in the presence of an alkali metal carbonate as base in a solvent such as DMF or acetonitrile. LG 1 may represent a nucleofugal group such as iodide, bromide, methanesulfonate, and the like. In this transformation, R 56 is a group such as but not limited to alkyl. The intermediate may be treated with an amine R 2 —NH 2 in the presence or absence of a tertiary amine base, in a solvent such as THF, at a temperature of from 0° C. to 100° C., to afford (14). Reduction of the nitro group in (14) may be accomplished by treatment of (14) in acidic or neutral ethanol with stannous chloride at a temperature of from 25° C. to 100° C. to afford the aniline (15). Alternately, (14) may be reduced by treatment of (14) with a noble metal catalyst such as palladium on charcoal and a hydrogen source such as gaseous hydrogen or ammonium formate, in a solvent such as ethanol, at a temperature of from 25° C. to 80° C., to afford (15). The difluoronitroaromatic compound (16) may be employed in similar manner, where in (16), one fluoro is ortho to the nitro group. Treatment of (16) with the one equivalent of amine R 2 —NH 2 gives preferential substitution of the ortho fluorine. The second fluorine in the intermediate may be substituted by an alcohol R 57 —OH to afford (17). In this instance, R 57 may also be aryl. Reduction of the nitro group in (17) as before with stannous chloride provides (18). Ar 4 represents a group such as but not limited to aryl or heteroaryl.

Scheme 5 describes synthesis of aryl diamines. The 2,4,6-trifluoronitroaromatic compound (19) may be treated with one equivalent of an amine R 2 —NH2 to afford the product of substitution at one ortho fluoro; excess R 58 —OH may then be employed in the presence of a base such as potassium tert-butoxide or sodium hydride to afford (20). Reduction of the nitro group as for Scheme 4 affords the aniline (21). Similarly, a 3,5-difluorophenolic aromatic compound (22) may be nitrated under strong nitrating conditions, e.g. fuming nitric acid, to afford the ortho nitro phenol (23) along with the para nitrophenol (24). Each individually may be processed by sequential phenol alkylation, ortho fluoro displacement by R 2 —NH 2 , and para or ortho fluorodisplacement by R 58 —OH, to afford (25) and (26) after reduction, following chemistries in the preceding general procedures. Ar 5 represents a group such as but not limited to aryl or heteroaryl.

Scheme 6 describes the synthesis of mono and di alkoxy-substituted aminoaryl and aminoheteroaryl compounds. A fluoronitroaromatic (27), where F is preferably ortho or para to the nitro, may be treated with an alcohol or phenol R 60 —OH and a base such as potassium tert-butoxide or sodium hydride, to afford the ipso adduct. Reduction of the nitro group to amino following preceding methods affords (28). Similarly, displacement of the fluoro groups in (29) with R 60 —OH followed by reduction as before give (30). The nitro compound (31) may be treated with a base and R 61 -LG 1 to afford the alkylation product, then treated with R 60 —OH and a base, then reduced as above to give (32). Alternately, (33) may be processed similarly to give (32). Ar6 represents a group such as but not limited to aryl or heteroaryl.

Scheme 7 describes a general synthesis of imidazoles. An aniline containing a basic side chain (—O—R 62 ) (40) may be coupled with a bromoketone containing a non-basic side chain (—O—R 63 ) (41) to give the aminoketone (42), which may then be treated with acetic acid, heat, an aldehyde R 1 —CHO, and ammonium acetate to afford (43). Alternately, (42) may be treated with an acid chloride R 1 —COCl to afford (44), which may subsequently be treated with ammonium acetate, acetic acid and heat to afford (43). Ar 7 and Ar 8 represent groups such as but not limited to aryl or heteroaryl.

Scheme 8 describes another general synthesis of imidazoles. An aniline containing a non-basic side chain (45) may be coupled with a bromoketone containing a basic side chain (46) to give the aminoketone (47), which may then be treated with acetic acid, heat, an aldehyde R 1 —CHO, and ammonium acetate to afford (48). Alternately, (42) may be treated with an acid chloride R 1 —COCl to afford (49), which may subsequently be treated with ammonium acetate, acetic acid and heat to afford (43). Ar 7 and Ar 8 represent groups such as but not limited to aryl or heteroaryl.

Scheme 9 describes another general synthesis of imidazoles. An aniline containing a basic side chain (40) may be coupled with a bromoketone (50) to give the aminoketone (51), which may then be treated with an acid chloride R 1 —COCl to afford (52), which may subsequently be treated with ammonium acetate, acetic acid and heat to afford (53). The phenol is then alkylated with a alkylating agent R 63 -LG 5 to generate the desired imidazole (54). R 63 is a group such as but not limited to substituted alkyl, and LG 5 is a leaving group such as iodide or methanesulfonate. Ar 7 and Ar 8 represent groups such as but not limited to aryl or heteroaryl.

Scheme 10 describes another general synthesis of imidazoles. An aniline containing a hydrophobic side chain (40) may be coupled with a bromoketone (55) to give the aminoketone (56), which may then be treated with an acid chloride R 1 —COCl to afford (57), which may subsequently be treated with ammonium acetate, acetic acid and heat to afford (58). The phenol is then deprotected; PG 1 may be a group sych as but not limited to benzyl, which may be removed with treatment with hydrogen over palladium on carbon. The free phenolic group is subsequently alkylated with an alkylating agent R 63 -LG 5 to generate the desired imidazole (59). R 63 is a group such as but not limited to substituted alkyl, and LG 5 is a leaving group such as iodide or methanesulfonate.

Scheme 11 describes the synthesis of diones or bromoketones. A aryl ketone (60) may be treated with base and an alkylating agent R 64 -LG 6 to generate the phenyl ether. R 64 is a group such as but not limited to substituted alkyl, and LG 6 is a leaving group such as iodide or methanesulfonate. The product may be brominated with a reagent such as but not limited to pyrrolidinium hydrotribromide, to (61) and the bromide may be oxidized by treatment with DMSO to afford (62). (63) may be treated with Ar 10 —OH and base, followed by bromination, to afford (64). Oxidation as before gives the dione (65). Ar 9 is a group such as but not limited to aryl or heteroaryl.

›Scheme 4 describes the synthesis of substituted arylenediamines · 2 of 7

Scheme 12 describes the synthesis of imidazoles. (66) may be treated with (67) and an aldehyde R 1 —CHO to afford (68). Alternately, (66) may be coupled with the bromoketone (70) to give the aminoketone (71), which may be treated with acetic acid, heat, an aldehyde R 1 —CHO, and ammonium acetate to afford (68). Ar 11 and Ar 12 are groups such as but not limited to aryl or heteroaryl.

Scheme 13 describes the synthesis of imidazoles. A dione (72) may be treated with R 1 —CHO and ammonium acetate-acetic acid to afford (74). Alternately, an amine R 2 —NH 2 may be used in place of ammonium acetate to give (75).

Scheme 14 describes another synthesis of imidazoles. (76) may be coupled with the bromoketone (77) to give the aminoketone (78), which may be treated with acetic acid, heat, an aldehyde R 1 —CHO, and ammonium acetate to afford (80). Alternately, (78) may be treated with an acid chloride R 1 —COCl to afford (79), which may subsequently be treated with ammonium acetate, acetic acid and heat to afford (80). The group R 68 may be an amino protecting group, such as BOC, which may be removed by treatment of (80) with TFA. The amine may be directly alkylated or reductively alkylated by methods known in the art. For example, treatment of the NH compound with acetaldehyde and sodium cyanoborohydride in a solvent such as acetic acid affords (80) where R 68 is ethyl. Ar 12 is a group such as but not limited to aryl or heteroaryl.

Scheme 15 describes the synthesis of imidazoles. A dione (81) may be treated with R 1 —CHO and an amine (76) in acetic acid, in the presence of ammonium acetate, at a temperature of from 50 to 140° C., to afford (83). If the group R 68 is an amine protecting group, then said protecting group may be removed and the nitrogen alkylated as described in Scheme 14.

The term “amino protecting group” as used herein refers to substituents of the amino group commonly employed to block or protect the amino functionality while reacting other functional groups on the compound. Examples of such amino-protecting groups include the formyl group, the trityl group, the phthalimido group, the trichloroacetyl group, the chloroacetyl, bromoacetyl and iodoacetyl groups, urethane-type blocking groups such as benzyloxycarbonyl, 4-phenylbenzyloxycarbonyl, 2-methylbenzyloxycarbonyl, 4-methoxybenzyloxycarbonyl, 4-fluorobenzyloxycarbonyl, 4-chlorobenzyloxycarbonyl, 3-chlorobenzyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 2,4-dichlorobenzyloxycarbonyl, 4-bromobenzyloxycarbonyl, 3-bromobenzyloxycarbonyl, 4-nitrobenzyloxycarbonyl, 4-cyanobenzyloxy-carbonyl, 2-(4-xenyl)iso-propoxycarbonyl, 1,1-diphenyleth-1-yloxycarbonyl, 1,1-diphenylprop-1-yloxycarbonyl, 2-phenylprop-2-yloxycarbonyl, 2-(p-toluyl)prop-2-yloxycarbonyl, cyclopentanyloxycarbonyl, 1-methylcyclopentanyloxycarbonyl, cyclohexanyloxycarbonyl, 1-methylcyclohexanyloxycarbonyl, 2-methylcyclohexanyloxycarbonyl, 2-(4-toluylsulfonyl)ethoxycarbonyl, 2(methylsulfonyl)ethoxycarbonyl, 2-(triphenylphosphino)ethoxycarbonyl, 9-fluorenylmethoxycarbonyl (“FMOC”), t-butoxycarbonyl (“BOC”), 2-(trimethylsilyl)ethoxycarbonyl, allyloxycarbonyl, 1-(trimethylsilylmethyl)prop-1-enyloxycarbonyl, 5-benzisoxalylmethoxycarbonyl, 4-acetoxybenzyloxycarbonyl, 2,2,2-trichloroethoxycarbonyl, 2-ethynyl-2-propoxycarbonyl, cyclopropylmethoxycarbonyl, 4-(decyloxy)benzyloxycarbonyl, isobornyloxycarbonyl, 1-piperidyloxycarbonyl and the like; the benzoylmethylsulfonyl group, the 2-(nitro)phenylsulfenyl group, the diphenylphosphine oxide group and like amino-protecting groups. The species of amino-protecting group employed is not critical so long as the derivatized amino group is stable to the condition of subsequent reaction(s) on other positions of the compound of Formula (I) and can be removed at the desired point without disrupting the remainder of the molecule. Preferred amino-protecting groups are the allyloxycarbonyl, the t-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, and the trityl groups. Similar amino-protecting groups used in the cephalosporin, penicillin and peptide art are also embraced by the above terms. Further examples of groups referred to by the above terms are described by J. W. Barton, “Protective Groups In Organic Chemistry”, J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, and T. W. Greene, “Protective Groups in Organic Synthesis”, John Wiley and Sons, New York, N.Y., 1981. The related term “protected amino” or “protected amino group” defines an amino group substituted with an amino-protecting group discussed above.

The term “hydroxyl protecting group” as used herein refers to substituents of the alcohol group commonly employed to block or protect the alcohol functionality while reacting other functional groups on the compound. Examples of such alcohol -protecting groups include the 2-tetrahydropyranyl group, 2-ethoxyethyl group, the trityl group, the trichloroacetyl group, urethane-type blocking groups such as benzyloxycarbonyl, and the trialkylsilyl group, examples of such being trimethylsilyl, tert-butyldimethylsilyl, phenyldimethylsilyl, triiospropylsilyl and thexyldimethylsilyl. The choice of alcohol-protecting group employed is not critical so long as the derivatized alcohol group is stable to the condition of subsequent reaction(s) on other positions of the compound of the formulae and can be removed at the desired point without disrupting the remainder of the molecule. Further examples of groups referred to by the above terms are described by J. W. Barton, “Protective Groups In Organic Chemistry”, J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, and T. W. Greene, “Protective Groups in Organic Synthesis”, John Wiley and Sons, New York, N.Y., 1981. The related term “protected hydroxyl” or “protected alcohol” defines a hydroxyl group substituted with a hydroxyl-protecting group as discussed above.

The term “carboxyl protecting group” as used herein refers to substituents of the carboxyl group commonly employed to block or protect the —OH functionality while reacting other functional groups on the compound. Examples of such alcohol -protecting groups include the 2-tetrahydropyranyl group, 2-ethoxyethyl group, the trityl group, the allyl group, the trimethylsilylethoxymethyl group, the 2,2,2-trichloroethyl group, the benzyl group, and the trialkylsilyl group, examples of such being trimethylsilyl, tert-butyldimethylsilyl, phenyldimethylsilyl, triiospropylsilyl and thexyldimethylsilyl. The choice of carboxyl protecting group employed is not critical so long as the derivatized alcohol group is stable to the condition of subsequent reaction(s) on other positions of the compound of the formulae and can be removed at the desired point without disrupting the remainder of the molecule. Further examples of groups referred to by the above terms are described by J. W. Barton, “Protective Groups In Organic Chemistry”, J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, and T. W. Greene, “Protective Groups in Organic Synthesis”, John Wiley and Sons, New York, N.Y., 1981. The related term “protected carboxyl” defines a carboxyl group substituted with a carboxyl-protecting group as discussed above.

›Scheme 4 describes the synthesis of substituted arylenediamines · 3 of 7

The general procedures used in the methods of the present invention are described below.

Methods

LC-MS data is obtained using gradient elution on a Waters 600 controller equipped with a 2487 dual wavelength detector and a Leap Technologies HTS PAL Autosampler using an YMC Combiscreen ODS-A 50×4.6 mm column. A three minute gradient is run from 25% B (97.5% acetonitrile, 2.5% water, 0.05% TFA) and 75% A (97.5% water, 2.5% acetonitrile, 0.05% TFA) to 100% B. The mass spectrometer used is a Micromass ZMD instrument. All data is obtained in the positive mode unless otherwise noted.

1 H NMR and 13 C NMR data is obtained on a Varian 400 MHz spectrometer.

Abbreviations used in the Examples are as Follows:

APCI=atmospheric pressure chemical ionization

BOC=tert-butoxycarbonyl

BOP=(1-benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate

d=day

DIAD=diisopropyl azodicarboxylate

DCC=dicyclohexylcarbodiimide

DCM=dichloromethane

DIC=diisopropylcarbodiimide

DIEA=diisopropylethylamine

DMA=N,N-dimethylacetamide

DMAP=dimethylaminopyridine

DME=1,2 dimethoxyethane

DMF=N,N-dimethylformamide

DMPU=1,3-dimethypropylene urea

DMSO=dimethylsulfoxide

Et=ethyl

iPr=isopropyl

Bn=benzyl

Me=methyl

tBu=tert-butyl

Pr=propyl

Bu=butyl

iBu=isobutyl

EDC=1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride

EDTA=ethylenediamine tetraacetic acid

ELISA=enzyme-linked immunosorbent assay

ESI=electrospray ionization

ether=diethyl ether

EtOAc=ethyl acetate

FBS=fetal bovine serum

g=gram

h=hour

HBTU=O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate

HMPA=hexamethylphosphoric triamide

HOBt=1-hydroxybenzotriazole

Hz=hertz

i.v.=intravenous

kD=kiloDalton

L=liter

LAH=lithium aluminum hydride

LDA=lithium diisopropylamide

LPS=lipopolysaccharide

M=molar

m/z=mass to charge ratio

mbar=millibar

MeOH=methanol

mg=milligram

min=minute

mL=milliliter

mM=millimolar

mmol=millimole

mol=mole

mp=melting point

MS=mass spectrometry

N=normal

NMM=N-methylmorpholine, 4-methylmorpholine

NMR=nuclear magnetic resonance spectroscopy

p.o.=per oral

PS-carbodiimide=N-cyclohexylcarbodiimide-N′-propyloxymethyl polystyrene

PBS=phosphate buffered saline solution

PMA=phorbol myristate acetate

ppm=parts per million

psi=pounds per square inch

R f =relative TLC mobility

rt=room temperature

s.c.=subcutaneous

SPA=scintillation proximity assay

TEA=triethylamine

TFA=trifluoroacetic acid

THF=tetrahydrofuran

THP=tetrahydropyranyl

TLC=thin layer chromatography

TMSBr=bromotrimethylsilane, trimethylsilylbromide

T r =retention time

General Synthesis of monoalkoxybenzaldehydes:

General Procedure A

To a stirred solution of a 2-, 3-, or 4-hydroxybenzaldehyde (2 mmol) in DMF (6 mL) at rt solid K 2 CO 3 (4 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.2 mmol) is added to the reaction mixture and heated to 80° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is poured into EtOAc (20 ml) and washed with water (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under high vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Synthesis of monoaryloxybenzaldehydes:

General Procedure B

To a stirred solution of a 2-, 3-, or 4-fluorobenzaldehyde (2 mmol) in DMF (6 mL) at rt requisite phenol (2.2) is added followed by solid K 2 CO 3 (3 mmol). The reaction mixture is heated to 100° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is poured into EtOAc (20 ml) and washed with water (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under high vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Synthesis of homo substituted 2,4-dialkoxybenzaldehydes:

General Procedure C

To a stirred solution of 2,4-dihydroxybenzaldehyde (2 mmol) in DMF (8 mL) at rt solid Cs 2 CO 3 (6 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (4.4 mmol) is added to the reaction mixture and heated to 80° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is poured into EtOAc (20 ml) and washed with water (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under high vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Synthesis of Hetero Substituted 2,4-dialkoxybenzaldehydes:

General Procedure D1

To a stirred solution of 2,4-dihydroxybenzaldehyde (2.2 mmol) in DMF (5 mL) at rt solid KHCO 3 (2.2 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (2.0 mmol) is added to the reaction mixture and heated at 130° C. for 4 h. After cooling to rt, the reaction mixture is treated with cold H 2 O (15 mL), and extracted with EtOAc (2×10 mL). The combined organic layers is washed with brine, and dried over sodium sulfate. The crude product is purified by flash chromatography to provide the 2-hydroxy-4-alkoxybenzaldehyde intermediate.

General Procedure D2

To a stirred solution of aforementioned 2-hydroxy-4-alkoxybenzaldehyde intermediate (2 mmol) in DMSO (5 mL) at rt solid Cs 2 CO 3 (3 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (3 mmol) is added to the reaction mixture and heated to 90° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is treated with cold H 2 O (15 mL), and extracted with EtOAc (2×10 mL). The combined organic layers is washed with H 2 O (10 mL) and brine (10 mL) and dried over sodium sulfate. After removal of the drying agent, the solvent is removed under high vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

›Scheme 4 describes the synthesis of substituted arylenediamines · 4 of 7

General Synthesis of 2-alkoxy-4-aryloxybenzaldehydes:

General Procedure E

A solution of 2,4-difluorobenzaldehyde (2 mmol) in DMF (2 mL) is added dropwise to a precooled (0° C.) solution of sodium alkoxide (2 mmol) in DMF (6 ml) [prepared by stirring a mixture of sodium hydride (2 mmol), and the corresponding alcohol (2 mmol) in DMF]. The resulting reaction mixture is warmed to rt and stirred for an additional 3 h. To the same reaction vessel, solid potassium carbonate (2 mmol) and requisite phenol (2 mmol)) is introduced and the reaction mixture is heated at 90° C. in an oil bath for 24. After cooling to rt, the reaction mixture is poured into EtOAc (20 ml) and washed with water (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under high vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Synthesis of monoalkoxy ortho-phenylenediamines:

Method A

General Procedure F1

To a stirred solution of 3-fluoro-4-nitrophenol (4 mmol) in DMF (6 mL) at rt solid K 2 CO 3 (8 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (4.4 mmol) is added to the reaction mixture and heated to 80° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is poured into EtOAc (40 ml) and washed with water (2×20 ml) and brine (30 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under vacuum to afford the desired product. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure F2

To a stirred solution of 2-fluoro-4-alkoxynitrobenzene (2 mmol) obtained above, TEA (4 mmol) in DMF (5 mL) is added dropwise a solution of requisite alkylamine (2.2 mmol) in DMF (2 mL) at rt within 15 min, and then stirred at rt for 5 h. The reaction mixture is treated with cold H 2 O (10 mL), and extracted with EtOAc (2×15 mL), The combined organic layers is washed with H 2 O (10 mL) and brine (10 mL) and dried over sodium sulfate. After removal of the drying agent, the solvent is removed under high vacuum to afford the desired 2-alkylamino-4-alkoxynitrobenzene intermediate. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography. cl Method B

General Procedure G1

To a stirred solution of 2,4-difluoronitrobenzene (2 mmol), TEA (4 mmol) in DMF (5 mL) is added dropwise a solution of requisite alkylamine (2.2 mmol) in DMF (2 mL) at rt within 15 min, and then stirred at rt for 5 h. The reaction mixture is treated with cold H 2 O (10 mL), and extracted with EtOAc (2×15 mL), The combined organic layers is washed with H 2 O (10 mL) and brine (10 mL) and dried over sodium sulfate. After removal of the drying agent, the solvent is removed under high vacuum to afford the desired 2-alkylamino-4-fluoronitrobenzene. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure G2

To a stirred solution of 2-alkylamino-4-fluoronitrobenzene as obtained above (2.0 mmol) in anhydrous THF (4 mL), an alcohol (2.4 mmol) is added followed by powdered KOBu t (2.4 mmol) in one portion at rt and under the N 2 stream. The reaction mixture is then refluxed until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is treated with cold H 2 O (15 mL), and extracted with EtOAc (2×10 mL). The combined organic layers is washed with brine, and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded 2-alkylamino-4-alkoxynitrobenzene intermediate. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

Reduction of monoalkoxy nitrobenzenes:

General Procedure H

The nitro intermediate (2 mmol) obtained above as in Method A or B is dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until the reaction is complete as indicated by TLC or HPLC. The reaction mixture is then filtered through a celite pad to remove the catalyst. The solvent is removed under high vacuum to afford the desired diamine, which is used directly for further transformation without further purification.

General Procedure I

To a stirred solution of afforded 2-alkylamino-4-alkoxynitrobenzene intermediate [as obtained in (b)](2 mmol) in EtOH (20 mL), SnCl 2 .2H 2 O (8 mmol) is added and the mixture is refluxed until the reaction is complete as indicated by TLC or HPLC. After completion of the reduction, the solvent is removed in vacuo, and the residue is treated with saturated NaHCO 3 to pH˜8. The resulting yellow suspension is extracted with DCM (2×20 mL), washed with brine, and dried. The solvent is removed under high vacuum to afford the desired diamine, which is used directly for further transformation without further purification.

General Synthesis of Homo Disubstituted dialkoxy ortho-phenylenediamines:

General Procedure J1

To a stirred solution of 2,4,6-trifluoronitrobenzene (3.0 mmol) and triethylamine (6.0 mmol) in DMF (6 mL), a solution of alkyl amine (3.0 mmol) in DMF (2 mL) is added dropwise at rt within 15 min, and then stirred at rt for 5 h. The reaction mixture is treated with cold H 2 O (10 mL), and extracted with EtOAc (2×15 mL), The combined organic layers is washed with H2O (10 mL) and brine (10 mL) and dried over sodium sulfate. After removal of the drying agent, the solvent is removed under high vacuum to afford the desired 2-alkylamino-4,6-difluoronitrobenzene. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

›Scheme 4 describes the synthesis of substituted arylenediamines · 5 of 7

General Procedure J2

To a stirred solution of 2-alkylamino-4,6-difluoronitrobenzene as obtained above (2.0 mmol) in anhydrous THF (4 mL), an alcohol (4.4 mmol) is added followed by powdered KOBu t (4.4 mmol) in one portion at rt and under the N 2 stream. The reaction mixture is then refluxed until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers is washed with brine, and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded 2-alkylamino-4,6-dialkoxynitrobenzene intermediate. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

The nitro intermediate (2 mmol) obtained may be reduces to the amino compound employing general procedures H or I.

General Synthesis of Hetero Disubstituted dialkoxy ortho-phenylenediamines:

General Procedure J3

To a stirred solution of 3,5-difluorophenol (3 g; 17 mmol) in dichloromethane (30 mL) at 0° C., conc. HNO 3 (2.5 mL) is added dropwise over 10 min. The reaction mixture is then stirred at 0° C. for 60 min at which the nitration is complete as indicated by TLC. After the reaction is complete cold H 2 O (30 mL) is added to the reaction flask and stirred. The contents are then poured into a separatory funnel and the layers removed. The aqueous layer is then extracted with EtOAc (2×30 mL) and the combined organic layers are dried over magnesium sulfate. After removal of the drying agent, the solvent is removed under vacuum to the crude product mixture is purified using silica gel column chromatography to provide the nitrodifluorophenol.

General Procedure J4

To a stirred solution of 3,5-difluoro-4-nitrophenol (4 mmol) in DMF (6 mL) at rt solid K 2 CO 3 (8 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (4.4 mmol) is added to the reaction mixture and heated to 80° C. until the reaction is complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is poured into EtOAc (40 ml) and washed with water (2×20 ml) and brine (30 ml). The organic layer is dried over magnesium sulfate and after removal of the drying agent, the solvent is removed under vacuum to afford the desired product. The crude product may be used. for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure J5

To a stirred solution of 2,6-difluoro-4-alkoxynitrobenzene obtained above (3.0 mmol) and triethylamine (6.0 mmol) in DMF (6 mL), a solution of alkyl amine (3.0 mmol) in DMF (2 mL) is added dropwise at rt within 15 min, and then stirred at rt for 5 h. The reaction mixture is treated with cold H 2 O (10 mL), and extracted with EtOAc (2×15 mL), The combined organic layers is washed with H2O (10 mL) and brine (10 mL) and dried over sodium sulfate. After removal of the drying agent, the solvent is removed under high vacuum to afford the desired 2-alkylamino-4-alkoxy-6-fluoronitrobenzene. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure J6

To a stirred solution of 2-alkylamino-4-alkoxy-6-fluoronitrobenzene as obtained above (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of an alkoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of KOBu t in THF) is added dropwise and under the N 2 stream. The reaction mixture is maintained at 0° C. until the reaction is complete as indicated by TLC or HPLC. The reaction mixture is then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers is washed with brine, and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the desired hetero dialkoxy substituted nitro intermediate. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure J7

The nitro intermediate (2 mmol) obtained above is dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until the reaction is complete as indicated by TLC or HPLC. The reaction mixture is then filtered through a celite pad to remove the catalyst. The solvent is removed under high vacuum to afford the desired hetero disubstituted dialkoxy ortho-phenylenediamine.

General Procedure for Synthesis of benzimidazoles:

General Procedure K

A solution of an ortho phenylenediamine (2 mmol) and an appropriate aryl aldehyde in ethanol is refluxed until the reaction is complete as indicated by TLC or HPLC. The solvent is removed in vacuo and the residue obtained is purified by silica gel column chromatography to afford the desired 2-arylbenzimidazole.

General Procedure for Synthesis of monoalkoxyanilines:

Method A:

General Procedure L1

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium alkoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of KOBu t in THF) is added dropwise and under the N 2 stream. The reaction mixture is stirred at 0° C. until completion, as indicated by TLC or HPLC. The reaction mixture is then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the desired 4-alkoxynitrobenzene. The crude product could be used directly for further transformation without any purification, or after purifying using silica gel column chromatography.

Method B:

General Procedure M1

To a stirred solution of 4-nitrophenol (2 mmol) in DMF (6 mL) at rt, solid potassium carbonate (4 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (2.2 mmol) is then added to the reaction mixture and heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the desired 4-alkoxynitrobenzene. The crude product could be used directly for further transformation without any purification, or after purifying using silica gel column chromatography.

›Scheme 4 describes the synthesis of substituted arylenediamines · 6 of 7

General Procedure for Synthesis of Homo Disubstituted alkoxy-anilines:

Method C

General Procedure N1

To a stirred solution of 2,4-difluoronitrobenzene (2.0 mmol) in anhydrous THF (4 mL) at 0° C., an alcohol (4.4 mmol) is added followed by powdered potassium t-butoxide (4.4 mmol) in one portion under a N 2 stream. The reaction mixture is then warmed to rt and heated under reflux until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the 2,4-dialkoxynitrobenzene. The crude product could then be used for further transformation without any purification, or after purifying using silica gel column chromatography.

General Procedure for Synthesis of alkoxy-anilines:

General Procedure O2

To a stirred solution of 4-alkoxy-2-fluoronitrobenzene obtained above (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of an alkoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of potassium t-butoxide in THF) is added dropwise and under a N 2 stream. The reaction mixture is maintained at 0° C. until completion, as indicated by TLC or HPLC. The reaction mixture is then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine, and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the desired hetero-substituted dilkoxynitrobenzene. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

Method E:

General Procedure P1

To a stirred solution of a 2-nitro-5-fluorophenol (2.0 mmol) in anhydrous THF (4 mL) at 0° C., an alcohol (2.2 mmol) is added followed by powdered potassium t-butoxide (4.2 mmol) in one portion under a N 2 stream. The reaction mixture is then warmed up to rt and heated under reflux until completion, as indicated by TLC or HPLC. After cooling to rt, the crude reaction mixture is treated with an alkyl halide or mesylate (2.2 mmol, prepared from the corresponding alcohol and methanesulfonyl chloride) and heated under reflux until completion, as indicated by TLC or HPLC. The reaction mixture is then cooled to rt, treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine, and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the hetero-substituted dilkoxynitrobenzene. The crude product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure P2

A primary or secondary alcohol (20 mmol, 1 eq) is dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) is added and the mixture is cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) is added slowly with stirring and the reaction mixture is stirred at 0° C. for an hour and at rt for another hour (until the reaction is complete by HPLC). The solvent is removed and to this saturated aqueous sodium bicarbonate is added. The product is extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent is removed in vacuo to afford the product methanesulfonate.

General Procedure for Synthesis of alkyl phenones;

Method F

General Procedure Q1

To a stirred solution of 4′-hydroxyacetophenone (1.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (3.0 mmol) is added. An alkyl halide or mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride, see General Procedure P2) (1.0 mmol) is added to the reaction mixture and heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is quenched by removing solvent in vacuo and treating the residue with saturated sodium bicarbonate. The aqueous layer is poured into EtOAc (20 ml) and washed with H 2 O (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate, and the solvent is removed in vacuo to afford the desired product. The crude alkylated product may be used for further transformation without any purification or after purifying using silica gel column chromatography.

Method G

General Procedure Q2

To a stirred solution of an alcohol (75 mmol) in DMSO (80 mL) at rt, solid cesium carbonate (150 mmol) is added. 4′-fluoro-alkylphenone (50 mmol) is added to the reaction mixture and heated to 90° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture is treated with saturated sodium bicarbonate (150 ml). The aqueous layer is extracted with diethyl ether (4×100 ml). The organic layer is washed with H 2 O (2×10 ml) and brine (15 ml). The organic layer is dried over magnesium sulfate, and the solvent is removed in vacuo to afford the desired alkoxy acetophenone. The crude alkylated acetophenone may be used for further transformation without any purification or after purifying using silica gel column chromatography.

General Procedure for N-aryl imidazoles:

Method H

General Procedure R1

To a stirred solution of alkoxyacetophenone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq.) is added. The reaction mixture is stirred under nitrogen at 0° C. for 1 h and is allowed to warm to ambient temperature until completion, as indicated by TLC or HPLC. The solvent is then removed in vacuo and the crude alpha-bromoacetophenone is used for further transformation.

General Procedure R2

To a stirred solution of an alkoxy aniline (1.2 eq., 2 mmol) in anhydrous DMF (5 mL) diisopropylethylamine (3 eq. 6 mmol) is added, followed by a slow addition of the alpha-bromoacetophenone described above (1.6 mmol). The reaction mixture is stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture is then diluted with cold H 2 O and the product is isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline is purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield˜50-60%).

›Scheme 4 describes the synthesis of substituted arylenediamines · 7 of 7

General Procedure R3

To a stirred solution of alkylated aniline described above (2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 6 mmol) is added, followed by a slow addition of an acid chloride or anhydride (3 eq., 6 mmol). The reaction mixture is stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC or HPLC. The solvent is removed in vacuuo, and the crude amide is used for further transformation.

General Procedure R4

To a stirred solution of the amide described above (2 mmol) in AcOH (2 mL), ammonium acetate (excess, ˜20 eq.) is added. The reaction mixture is stirred at 90° C. overnight. The reaction mixture is then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which is purified by column chromatography (Silica gel). Pure product is obtained from 4-6% MeOH/DCM (yield 40-50%).

General Procedure S1

To a stirred solution of an alkoxy aniline (2 mmol) in DCM (4 mL) at rt, TEA (2.5 mmol) is added followed by an acid chloride or anhydride (2.5 mmol). The reaction mixture is stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture is treated with saturated aqueous sodium bicarbonate solution (5 mL), then extracted with EtOAc (2×15 mL). The combined organic layers were washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the anilide. The crude product is used for further transformation.

General Procedure S2

To a stirred solution of the anilide (2 mmol) obtained as above in anhydrous THF (4 mL) solid sodium hydride (60% dispersion in oil; 2.2 mmol) is added in portions. After the addition, a solution of a bromo-acetophenone (2.2 mmol) (prepared as described earlier) in anhydrous THF (2 mL) is added to the reaction mixture. The reaction is then allowed to proceed at rt or heated under reflux as needed. Upon completion of the reaction, EtOAc (20 mL) is added to the reaction mixture followed by H 2 O (10 mL). The organic layer is washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the N-alkylated anilide. The crude product may be used for further transformation.

General Procedure S3

To a stirred solution of the N-alkylated anilide (1 mmol) obtained as above in AcOH (3 mL), solid NH 4 OAc (20 mmol) is added in one portion. The reaction mixture is then heated to 100° C. overnight. The reaction mixture is cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH is 7-8. The contents were extracted with EtOAc (2×15 mL). The combined organic layers is washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product is purified using silica gel column chromatography.

General Procedure T1

4N hydrogen chloride in dioxane solution (4 mmol) is added to a mixture of BOC-amino compound (1 mmol) in anhydrous DCM (5 mL), and the mixture is stirred at rt until complete. Evaporation of the solvents in vacuo afforded deprotected amine hydrochloride.

General Procedure T2

A benzyl alkyl ether, benzyl ester, or a benzyl phenyl ether is dissolved in MeOH and hydrogenated in the presence of 10% Pd/C catalyst until the reaction is complete. reaction mixture is then filtered through a celite pad to remove the catalyst. Evaporation of the solvent in vacuo afforded the alcohol, carboxylic acid, or phenol, respectively.

General Procedure T3

A phenol (0.2 mmol) in anhydrous DMF (5 mL) is alkylated by a bromide or a mesylate (0.3 mmol) at rt (for a bromide, 60% NaH as base) or at 90° C. (for a mesylate, K 2 CO 3 as base). The reaction is quenched by adding sat. NaHCO 3 . The resulting mixture is extracted with EtOAc washed with brine and dried. The crude product is purified by silica gel column chromatography if desired.

›Examples128

›EXAMPLE 1

1-Butyl-2-(3-cyclohexylmethoxy-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole

Hydroxy benzimidazole was formed employing 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (synthesized via General Procedures G1 and G2 and H) (2.92 g; 10 mmol) and 3-hydroxybenzaldehyde (1.34 g, 11 mmol) in ethanol (20 mL) following the general procedure K. The crude product was purified by silica gel column chromatography using 2% MeOH in DCM (3.2 g).

MS m/z 396 (M+H) +

A solution of above mentioned hydroxybenzimidazole compound (39.4 mg, 0.1 mmol) in THF (2 ml) was added cyclohexylmethyl bromide (19.5 mg, 0.11 mmol) and NaH (0.8 mg, 60%, 0.12 mmol) at 0° C. The resulting reaction mixture was warmed to rt and stirred for additional 12 h. The mixture was quenched with brine and extracted into EtOAc (2×10 mL). Combined organic EtOAc extracts were dried over sodium sulfate and concentrated to give compound which was purified by silica gel column chromatography using dichloromethane and 2% methanol in dichloromethane as eluent, to give N-BOC compound, which was subjected to General Procedure T1 affording 1-butyl-2-(3-cyclohexylmethoxy-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole as a hydrochloride salt, 36.8 mg.

MS m/z 491 (M+H) +

›EXAMPLE 2

(3-(3-butyl-2-(3-,5-di-tert-butyl-2-methoxy-phenyl)-3H-benzimidazol-5-yloxy-propyl)-diethyl-amine

This compound was prepared according to the general procedure K by refluxing a mixture of 3,5-di-t-butyl-5-methoxybenzaldehyde (100 mg) and N 2 -Butyl-4-(3-diethylamino-propoxy)-benzene-1,2-diamine (synthesized via General Procedures G1 and G2 and H) (50 mg) in ethanol overnight. Ethanol was removed in vacuo and the residue was purified by silica gel chromatography using 5% MeOH in DCM to give (3-(3-butyl-2-(3-,5-di-tert-butyl-2-methoxy-phenyl)-3H -benzimidazol-5-yloxy-propyl)-diiethyl-amine (45.0 mg).

MS: m/z 522 (M+H) +

›EXAMPLE 3

(2-(3-butyl-2-(3-(4-tert-butyl-phenoxy)-phenyl)-3H-benzimidazol-5-yloxy-ethyl)-diisopropyl-amine

A solution of 2-(n-butylamino)-4-(2-diisopropylaminoethoxy)aniline (synthesized via General Procedures G1 and G2 and H) (61.4 mg, 0.2 mmol) and (3-(4-tert-butyl-phenoxy)-benzaldehyde (synthesized via General Procedure B) (56 mg, 0.22 mmol) in ethanol (2 mL) was condensed following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford (2-(3-butyl-2-(3-(4-tert-butyl-phenoxy)-phenyl)-3H-benzimidazol-5-yloxy-ethyl)-diisopropyl-amine (54 mg).

MS m/z 542 (M+H) +

›EXAMPLE 4

(3-{4-[1-butyl-6-(4-tert-butyl-phenoxy)-1H-benzimidazol-2-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-hydroxybenzaldehyde (20 mmol) in DMSO (80 mL) at rt, solid Cs 2 CO 3 (50 mmol) was added. A mesylate (prepared from 3-diethylamino-1-propanol and methanesulfonyl chloride, General Procedure P2) (30 mmol) was added to the reaction mixture and heated to 90° C. until the reaction was complete as indicated by LC-MS (10 h). After cooling to rt, the reaction was quenched by cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo, and the crude product was purified by silica gel column chromatography, eluting with 10% MeOH in DCM+0.5% Et 3 N, giving the desired 4-(3-diethylaminopropoxy)benzaldehyde.

A solution of 2-t-butylamino-4-(4-n-butylphenoxy)aniline (synthesized via General Procedures G1 and G2 and H) (130 mg, 0.4 mmol) and 4-(3-diethylaminopropoxy)benzaldehyde obtained above (70 mg, 0.3 mmol) in MeOH (10 mL) was subjected to General Procedure K. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), affording the desired benzimidazole (120 mg).

MS m/z 528 (M+H) +

1 H NMR (400 MHz, CDCl 3 ): δ 0.84 (t, 3H), 1.05 (t, 6H), 1.24 (m, 2H), 1.31 (s, 9H), 1.75 (m, 2H), 1.98 (m, 2H), 2.58 (q, 4H), 2.66 (t, 2H), 4.09 (t, 2H), 4.13 (t, 2H), 6.93 (d, 2H,), 7.00 (dd, 1H), 7.02 (d, 2H), 7.07 (d, 1H), 7.33 (d, 2H,), 7.62 (d, 2H), 7.72 (d, 1H) ppm.

›EXAMPLE 5

1-butyl-6-(4-tert-butyl-phenoxy)-2-[3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzimidazole

To a stirred solution of 3-hydroxybenzaldehyde (20 mmol) in DMSO (50 mL) at rt, solid Cs 2 CO 3 (60 mmol) was added. 1-(2-chloroethyl)pyrrolidine hydrochloride (30 mmol) was added to the reaction mixture and heated to 90° C. for 9 h. After cooling to rt, the reaction was quenched by cold H 2 O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo to afford crude 3-(2-pyrrolidin-1-yl-ethoxy)benzaldehyde.

A solution of 2-t-butylamino-4-(4-n-butylphenoxy)aniline (synthesized via General Procedures G1 and G2 and H) (130 mg, 0.4 mmol) and 3-(2-pyrrolidin-1-yl-ethoxy)benzaldehyde obtained above (70 mg, ˜0.3 mmol) in MeOH (10 mL) was subjected to General Procedure K. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), to afford the desired benzimidazole (100 mg).

MS m/z 512 (M+H) +

1 H NMR (400 MHz, CDCl 3 ): δ0.83 (t, 3H), 1.22 (m, 2H), 1.29 (s, 9H), 1.74 (m, 2H), 1.87 (m, 4H), 2.78 (m, 4H), 3.03 (m, 2H), 4.16 (t, 2H), 4.25 (m, 2H), 6.94 (d, 2H), 7.01 (br d, 1H), 7.07 (m, 2H), 7.26 (m, 2H), 7.33 (d, 2H), 7.41 (t, 1H), 7.74 (d, 1H) ppm.

The following Examples were synthesized according to the Methods employed for Examples 1-5;

›EXAMPLE 31

(2-(3-butyl-2-(2,4,4-trimethylpentyl)-3H -benzimidazol-5-yloxy-propyl)-diethyl-amine

A solution of 2-(n-butylamino)-4-(3-diethylaminopropoxy)aniline (synthesized via General Procedures G1 and G2 and H) (58.6 mg, 0.2 mmol) and 3,5,5-trimethylhexanal (31.2 mg, 0.22 mmol) in ethanol (2 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford (2-(3-butyl-2-(2,4,4-trimethylpentyl)-3H-benzimidazol-5-yloxy-propyl)-diethyl-amine (41.0 mg).

MS m/z 416 (M+H) +

›EXAMPLE 32

1-[(5-pyrrolidin-1-yl)pentyl-6-(3-diethylaminopropoxy)-2-piperidin-3-yl-1H-benzimidazole

A solution of 1-(t-butyloxycarbonyl)piperidine-3-carboxaldehyde (235 mg; 1.1 mmol) and 2-[(5-pyrrolidin-1-yl)pentylamino]-4-(3-diethylaminopropoxy)-4-(2-diethylaminoethoxy)aniline (synthesized via General Procedures G1 and G2 and H) (362 mg; 1 mmol) in ethanol (5 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 410 mg of tert-butyl 3-{[1-(5-pyrrolidin-1-yl)pentyl]-6-(3-diethylaminopropoxy)-1H-benzimidazol-2-yl}piperidine-1-carboxylate.

A solution of tert-butyl 3-{[1-(5-pyrrolidin-1-yl)pentyl]-6-(3-diethylaminopropoxy)-1H-benzimidazol-2-yl}piperidine-1-carboxylate (271 mg; 0.5 mmol) in DCM (2 mL) was subjected to General Procedure T1. The resulting mixture was stirred for 4-5 h and the solvent was removed in vacuo. The residue obtained was washed with ether twice and dried under vacuum to afford 1-[(5-pyrrolidin-1-yl)pentyl-6-(3-diethylaminopropoxy)-2-piperidin-3-yl-1H-benzimidazole trihydrochloride (210 mg).

MS m/z 442 (M+H) +

›EXAMPLE 33

1-[(5-pyrrolidin-1-yl)pentyl-6-(3-diethylaminopropoxy)-2-piperidin-4-yl-1H-benzimidazole

A solution of 1-(t-butyloxycarbonyl)piperdine-4-carboxaldehyde (235 mg; 1.1 mmol) and 2-[(5-pyrrolidin-1-yl)pentylamino]-4-(3-diethylaminopropoxy)-4-(2-diethylaminoethoxy)aniline (362 mg; 1 mmol) in ethanol (5 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 430 mg of tert-butyl 4-{[1-(5-pyrrolidin-1-yl)pentyl]-6-(3-diethylaminopropoxy)-1H-benzimidazol-2-yl}piperidine-1-carboxylate.

A solution of tert-butyl 4-{[1-(5-pyrrolidin-1-yl)pentyl]-6-(3-diethylaminopropoxy)-1H-benzimidazol-2-yl)piperidine-1-carboxylate (271 mg; 0.5 mmol) in DCM (2 mL) was subjected to General Procedure T1. The resulting mixture was stirred for 4-5 h and the solvent was removed in vacuo. The residue obtained was washed with ether twice and dried under vacuum to afford 1-[(5-pyrrolidin-1-yl)pentyl-6-(3-diethylaminopropoxy)-2-piperidin-4-yl-1H-benzimidazole trihydrochloride (220 mg).

MS m/z 442 (M+H) +

›EXAMPLE 34

{1-butyl-[4,6-di(3-diethylaminopropoxy)]-2-piperidin-4-yl}-1H-benzimidazole

A solution of 1-(t-butyloxycarbonyl)piperdine-4-carboxaldehyde (235 mg; 1.1 mmol) and 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline (synthesized via General Procedures J1 and J2 and I) (424 mg; 1 mmol) in ethanol (5 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 425 mg of tert-butyl {4-[1-butyl-4,6-di(3-diethylaminopropoxy)-1H-benzimidazol-2-yl]}piperidine-1-carboxylate.

A solution of tert-butyl 4-[1-butyl-4,6-di(3-diethylaminopropoxy)-1H-benzimidazol-2-yl]piperidine-1-carboxylate (308 mg; 0.5 mmol) in DCM (2 mL) was subjected to General Procedure T1. The resulting mixture was stirred for 4-5 h and the solvent was removed in vacuo. The residue obtained was washed with ether twice and dried under vacuum to afford {1-butyl-[4,6-di(3-diethylaminopropoxy)]-2-piperidin-4-yl)-1H-benzimidazole trihydrochloride (260 mg).

MS m/z 516 (M+H) +

›EXAMPLE 35

(3-(3-butyl-2-(3-(4-tert-butyl-phenoxy)-phenyl)-7-(2-pyrrolidin-1-yl-ethoxy)-3H-benzimidazol-5-yloxy-propyl)-diiethyl-amine

Example 35 was formed employing 3-(4-t-butyl-phenoxy)benzaldehyde (synthesized via General Procedure B) (50 mg; 0.20 mmol) and 2-butylamino-4-(3-diethylaminopropoxy)-6-(2-pyrrolidin-1-yl-ethoxy)aniline (synthesized via General Procedures J3-J7) (39 mg; 0.20 mmol) in ethanol (1 mL) according to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 40 mg of Example 243.

MS m/z 641 (M+H) +

›EXAMPLE 36

1-butyl-2-{4-[2-(4-chlorophenyl)ethoxy]-phenyl}-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole

This compound was prepared according to the General Procedure K by refluxing a mixture of 4-[2-(4-chloro-phenyl)-ethoxy]-bezaldehyde (synthesized via General Procedure A) (100 mg) and N 2 -Butyl-4-(2-pyrrolidin-1-ylethoxy)-benzene-1,2-diamine (synthesized via General Procedures G1 and G2 and H) (50 mg) in ethanol overnight. Ethanol was removed in vacuo and the residue was purified by silica gel chromatography using 5% MeOH in DCM to give pure 1-butyl-2-{4-[2-(4-chlorophenyl)ethoxy]-phenyl}-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole (37.0 mg, 40%).

MS: m/z 518 (M+H) +

›EXAMPLE 37

1-butyl-2-{3-[3-tert-butyl-phenoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole

A mixture of 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (synthesized via General Procedures G1 and G2 and H) (0.130 g, 0.512 mmol) and 3-(3-tert-butylphenoxy)benzaldehyde was subjected to General Procedure K. Reaction was concentrated and purified on silica gel chromatography using DCM-2% MeOH/DCM. The BOC-group was removed employing General Procedure T1 to give 1-butyl-2-{3-[3-tert-butyl-phenoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole (0.10 g).

MS (m/z): 527 (M+H) +

›EXAMPLE 38

1-butyl-2-{3-[biphenyl-4-yloxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole

A mixture of 3-bromobenzaldehyde (1.05 g) and 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (1.85 g) was subjected to General Procedure K. The ethanol was removed in vacuo and the residue purified on silica gel, using 1-2% MeOH/DCM.

To a solution of the aryl bromide (0.07 mmol) in pyridine (1 mL) was added copper powder (0.14 mmol) followed by K 2 CO 3 (0.35 mmol) and the respective substituted phenol (0.14 mmol). The mixture was heated at 110° C. overnight, then diluted with water (2 mL) and extracted with EtOAc (3×2 mL). The combined organic extract was dried over Na 2 SO 4 , filtered and concentrated to an oil, which was purified by column chromatography on silica gel. The pure product was obtained from 1--6% methanol/DCM (yield 28-42%). The BOC-group was removed via General Procedure T1 to give 1-butyl-2-{3-[biphenyl-4-yloxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole.

MS (m/z): 547 (M+H) +

›EXAMPLE 39

1-butyl-2-{4-[2-(4-chlorophenyl)ethoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole

A mixture of 4-[2-(4-chloro-phenyl)-ethoxy]-benzaldehyde (0.08 g)and 1-BOC-4-[2-(4-amino-3-butylamino-phenoxy)-ethyl]-piperazine (0.10 g) was subjected to General Procedure K. Ethanol was removed in vacuo and the residue purified on silica gel with 1-2% MeOH/DCM. The BOC-group was removed employing General Procedure T1 to give 1-butyl-2-{4-[2-(4-chlorophenyl)ethoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole (0.081 g).

MS (m/z): 533 (M+H) +

The following Examples were synthesized according to the Methods employed for Examples 35-39;

›EXAMPLE 166

(3-(1-Butyl-2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-6-(3-diethylaminopropoxy)-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine

This compound was prepared according to General Procedure K by refluxing a mixture of 4-[2-(4-chloro-phenyl)-ethoxy]-bezaldehyde (300 mg) and N 1 -Butyl-3,5-bis-(3-diethylamino-propoxy)-benzene-1,2-diamine (synthesized via General Procedures J1 and J2 and I) (200 mg) in ethanol overnight. Ethanol was removed in vacuo and the residue was purified by silica gel chromatography using 5% MeOH in DCM to give pure (3-(1-Butyl-2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-6-(3-diethylaminopropoxy)-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine (100 mg).

MS: m/z 663 (M+H) +

›EXAMPLE 167

{3-[1-Butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(3-diethylaminopropoxy)-1H-benzimidazole-4-yloxy]-propyl}diethyl-amine

{3-[1-Butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(3-diethylaminopropoxy)-1H-benzimidazole-4-yloxy]-propyl}diethyl-amine was formed employing 3(4-t-butyl-phenoxy)benzaldehyde (127 mg; 0.50 mmol) and 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline (synthesized via General Procedures J1 and J2 and I) (1.6 mg; 0.25 mmol) in ethanol (1 mL) following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 145 mg (76%) of {3-[1-Butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(3-diethylaminopropoxy)-1H-benzimidazole-4-yloxy]-propyl}diethyl-amine.

MS: m/z 657 (M+H) +

›EXAMPLE 168

{3-[2-(2-[4-[2-(4-chloro-phenyl)-ethoxy])-phenyl]-ethyl)-6-(3-diethylaminopropoxy)-3H-benzimidazole-4-yloxy]-propyl}diethyl-amine

This compound was prepared according to the General Procedure K by refluxing a mixture of 3-{4-[2-(4-chloro-phenyl)-ethoxy]-propionaldehyde (100 mg) and 3,5-Bis-(3-diethylamino-propxy)-benzene-1,2-diamine (synthesized via General Procedures J1 and J2 and I) (50 mg) in ethanol overnight. Ethanol was removed in vacuo and the residue was purified by silica gel chromatography using 10% MeOH in DCM to give {3-[2-(2-[4-[2-(4-chloro-phenyl)-ethoxy])-phenyl]-ethyl)-6-(3-diethylaminopropoxy)-3H-benzimidazole-4-yloxy]-propyl}diethyl-amine (30 mg).

MS: m/z 635 (M+H) +

›EXAMPLE 169

(3-(1-Butyl-6-(3-diethylaminopropoxy)-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine

4-(4-Chloro-3-trifluoromethyl)phenoxybenzaldehyde (synthesized employing General Procedure B) (150 mg) and 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline (synthesized via General Procedures J1 and J2 and I) 106 mg; 0.25 mmol) in ethanol (1 mL) were condensed employing General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 160 mg of (3-(1-Butyl-6-(3-diethylaminopropoxy)-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine.

MS: m/z 703 (M+H) +

›EXAMPLE 170

(3-(1-Butyl-6-(3-diethylaminopropoxy)-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine

A solution of 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline (synthesized via General Procedures J1 and J2 and I) (84.4 mg, 0.2 mmol) and 4-(4-fluoro-3-trifluoromethyl)phenoxybenzaldehyde (synthesized employing General Procedure B) (62.5 mg, 0.2 mmol) in ethanol (2 mL) was heated to reflux following the General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 3-(1-Butyl-6-(3-diethylaminopropoxy)-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzimidazole-4-yloxy)-propyl)diethyl-amine (62 mg).

MS m/z 687 (M+H)

The following Examples were synthesized according to the Methods employed for Examples 166-170;

›EXAMPLE 255

{3-[2-(1-butyl-6-(4-tert-butyl-phenoxy)-1H-benzimidazol-2-yl}-5-(3-diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 2,4-dihydroxybenzaldehyde (10 mmol) in DMSO (50 mL) at rt, solid Cs 2 CO 3 (45 mmol) was added. A mesylate (prepared from 3-diethylamino-1-propanol and methanesulfonyl chloride, General Procedure P2) (25 mmol) was added to the reaction mixture and heated to 90° C. until the reaction was complete as indicated by LC-MS (˜10 h). After cooling to rt, the reaction was quenched by cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo to afford the desired 2,4-bis(3-diethylaminopropoxy)benzaldehyde which was used for further transformation.

To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et 3 N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.

A mixture of 2-n-butylamino-4-fluoronitrobenzene (10 mmol), 4-t-butylphenol (13 mmol), solid K 2 CO 3 (30 mmol) and DMF (30 mL) was heated with stirring at 90° C. for 10 h. The reaction was quenched by cold H 2 O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (2×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo, and the crude products were purified by silica gel column chromatography (eluting with 10% EtOAc in hexane), giving 2-n-butylamino-4-(4-t-butylphenoxy)nitrobenzene.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by LC-MS (˜4 h). The reaction mixture was then filtered through a celite pad to remove the catalyst. The MeOH solution containing 2-n-butylamino-4-(4-t-butylphenoxy)aniline was used directly for further transformation.

A solution of 2-n-butylamino-4-(4-t-butylphenoxy)aniline (130 mg, 0.4 mmol) and 2,4-bis(3-diethylaminopropoxy)benzaldehyde obtained above (110 mg, 0.3 mmol) in MeOH (10 mL) was refluxed until the reaction was complete. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), to afford the desired benzimidazole (100 mg).

MS m/z 657 (M+H) +

1 H NMR (400 MHz, CDCl 3 ) of HCl salt of the benzimidazole: δ 0.80 (t, 3H), 1.19 (m, 2H), 1.26 (t, 6H), 1.32 (s, 9H), 1.41 (t, 6H), 1.74 (m, 2H), 2.44 (m, 4H), 3.12-3.39 (m, 12H), 4.21 (t, 2H), 4.29 (m, 4H), 6.68 (br d, 1H), 6.79 (br s, 1H), 6.98 (d, 2H), 7.17 (d, 1H), 7.22 (dd, 1H), 7.35 (d, 1H), 7.40 (d, 2H), 8.06 (d, 1H), 11.4 (br, N.HCl), 11.9 (br, N.HCl) ppm.

›EXAMPLE 256

(3-{2-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-5-[2-(4-hloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethylamine

A solution of 2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (synthesized via General Procedures D1 and D2) (429 mg; 1.1 mmol) and 2-(n-butylamino)-4-(3-diethylaminopropoxy)aniline (synthesized via General Procedures G1 and G2 and I) (293 mg; 1 mmol) in ethanol (5 mL) was heated to reflux following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford of (3-{2-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethylamine (430 mg).

MS m/z 663 (M+H) +

›EXAMPLE 257

(3-{1-butyl-6-(4-tert-butyl-phenoxy)-2-[4-(3-diethylamino-propoxy)-phenyl]-1H-benzimidazol-4-yloxy}propyl)-diethyl-amine

To a stirred solution of 4-hydroxybenzaldehyde (20 mmol) in DMSO (80 mL) at rt, solid Cs 2 CO 3 (50 mmol) was added. The mesylate prepared from 3-diethylamino-1-propanol and methanesulfonyl chloride, General Procedure P2 (30 mmol) was added to the reaction mixture and heated to 90° C. until the reaction was complete. After cooling to rt, the reaction was quenched by cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo, and the crude product was purified by silica gel column chromatography (eluting with 10% MeOH in DCM+0.5% Et 3 N) to afford 4-(3-diethylaminopropoxy)benzaldehyde.

To a stirred solution of 6-(3-diethylaminopropoxy)-2,4-difluoronitrobenzene (11 mmol) and triethylamine (22 mmol) in DMF (20 mL), a solution of n-butylamine (11 mmol) in DMF (8 mL) was added dropwise at rt, and the mixture was stirred at rt for 10 h. The reaction was quenched by cold H 2 O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo to afford the desired 2-n-butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene which was used for further transformation.

A mixture of 2-n-butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene obtained above (3 mmol), 4-t-butylphenol (4 mmol), solid K 2 CO 3 (9 mmol) and DMF (15 mL) was heated with stirring at 90° C. for 15 h. The reaction was quenched by cold H 2 O (30 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (2×50 mL) and dried (anhydrous Na 2 SO 4 ). The solvent was removed in vacuo, and the crude products were purified by silica gel column chromatography (eluting with 10% MeOH in DCM), giving 2-n-butylamino-4-(4-t-butylphenoxy)-6-(3-diethylaminopropoxy)nitrobenzene.

The nitro intermediate (1 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (40 mg) until completion as indicated by LC-MS (˜4 h). The reaction mixture was then filtered to remove the catalyst. The MeOH solution containing 2-n-butylamino-4-(4-t-butylphenoxy)-6-(3-diethylaminopropoxy)aniline was used directly for further transformation.

A solution of 2-n-butylamino-4-(4-t-butylphenoxy)-6-(3-diethylaminopropoxy)-aniline (90 mg, 0.2 mmol) and 4-(3-diethylaminopropoxy)benzaldehyde obtained above (65 mg, 0.25 mmol) in MeOH (10 mL) was refluxed until the reaction was complete as indicated by LC-MS (˜10 h). The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), to afford the desired benzimidazole (80 mg).

MS m/z 657 (M+H) +

1 H NMR (400 MHz, CDCl 3 ) of HCl salt of the benzimidazole: δ 0.80 (t, 3H), 1.21 (m, 2H), 1.31 (s, 9H), 1.40 (m, 12H), 1.74 (m, 2H), 2.39 (m, 2H), 2.52 (m, 2H), 3.17-3.27 (m, 12H), 3.80 (m, 2H), 4.18 (m, 4H), 6.60 (br s, 1H), 6.62 (br s, 1H), 6.95 (d, 2H), 7.14 (br, 2H), 7.39 (d, 1H), 7.80 (br, 2H), 11.17 (br, N.HCl), 11.83 (br, N.HCl) ppm.

›EXAMPLE 258

2-{2,4-bis-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl}-1-butyl-6-(4-tert-butyl-phenoxy)-1H-benzimidazole

A solution of 2-n-butylamino-4-(4-t-butylphenoxy)aniline (synthesized via General Procedures J3-J7) (100 mg, 0.3 mmol) and 2,4-bis[2-(1-methyl-2-pyrrolidin-2-yl)-ethoxy]benzaldehyde (synthesized via General Procedure C) (55 mg, 0.15 mmol) in MeOH (10 mL) was subjected to General Procedure K. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), to afford the desired benzimidazole (50 mg).

MS m/z 653 (M+H) +

1 H NMR (400 MHz, CDCl 3 ): δ 0.73 (t, 3H), 1.10-2.53 (m, 22H), 1.32 (s, 9H), 2.20 (s, 3H), 2.39 (s, 3H), 3.94-3.99 (m, 6H), 6.50 (m, 2H), 6.92 (d, 2H), 6.98 (m, 1H), 7.05 (d, 1H), 7.32 (d, 2H), 7.42 (d, 1H), 7.70 (d, 1H) ppm.

›EXAMPLE 259

2-[2,4-bis-(2-pyrrolidin-1-yl)-ethoxy]-phenyl}-1-butyl-6-(4-butyl-phenoxy)-1H-benzimidazole

A solution of 2-n-butylamino-4-(4-n-butylphenoxy)aniline (synthesized via General Procedures G1 and G2 and I) (80 mg, 0.25 mmol) and 2,4-bis(2-pyrrolidin-1-yl-ethoxy)benzaldehyde (synthesized via General Procedure C) (50 mg, 0.15 mmol) was subjected to General procedure K. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with 10% MeOH in DCM with a gradual increment of Et 3 N (0.5 to 1%), to afford the desired benzimidazole (80 mg).

MS m/z 625 (M+H) +

1 H NMR (400 MHz, CDCl 3 ): δ0.73 (t, 3H), 0.92 (t, 3H), 1.10 (m, 2H), 1.35 (m, 2H), 1.55-1.60 (m, 4H), 1.64 (m, 4H), 1.83 (m, 4H), 2.39 (m, 4H), 2.58 (t, 2H), 2.65 (m, 4H), 2.73 (t, 2H), 2.93 (t, 2H), 3.96 (t, 2H), 4.07 (t, 2H), 4.16 (t, 2H), 6.60 (br s, 1H), 6.62 (dd, 1H), 6.92 (d, 2H), 6.96 (dd, 1H), 7.04 (d, 1H), 7.12 (d, 2H), 7.40 (d, 1H), 7.70 (d, 1H) ppm.

The following Examples were synthesized according to the Methods employed for Examples 255-259;

›EXAMPLE 327

{3-[1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-(pyrrolidin-1-yl-ethoxy)-phenyl]-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine

4-[2-(4-chloro-phenyl)-ethoxy]-[2-(2-pyrrolidin-1-yl-ethoxy]-benzaldehyde (synthesized via General Procedures D1 and D2) (0.030 g, 0.080 mM) and N-butyl-3,5-bis (3-dimethylamino-propoxy) benzene-1,2-diamine (0.035 g, 0.080 mM) were subjected to General Procedure K. After removal of ethanol, the residue was purified on silica gel using 10% MeOH/DCM with 0.1-0.4% Et 3 N, yield 0.025 g LC/MS (m/z): 776 (M+H) +

›EXAMPLE 328

1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole

A solution of 2-butylamino-4,6-bis(2-pyrrolidinyl-1-ethoxy)aniline (synthesized via General Procedures G1 and G2 and H) (78.4 mg, 0.2 mmol) and 2-pyrrolidin-1-yl-ethoxy-4-(4-fluoro-3-trifluoromethyl)phenoxybenzaldehyde (synthesized via General Procedure E) (91 mg, 0.22 mmol) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford Example 328 (62 mg).

MS m/z 768 (M+H) + .

›EXAMPLE 329

1-Butyl-2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole

A solution of 2-butylamino-4,6-bis(2-pyrrolidinyl-1-ethoxy)aniline (synthesized via General Procedures G1 and G2 and H) (78.4 mg, 0.2 mmol) and 2-pyrrolidin-1-yl-ethoxy-4-(4-chloro-3-trifluoromethyl)phenoxybenzaldehyde (synthesized via General Procedure E) (91 mg, 0.22 mmol) in ethanol (2 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford Example 329 (62.5 mg)

MS m/z 784 (M+H) +

›EXAMPLE 330

(3-{2-[1-butyl-6-(3-diethylamino-propoxy)-4-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine

A solution of 2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (synthesized via General Procedure E) (858; 2.2 mmol) and 2-(n-butylamino)-4-(N,N-diethylaminopropoxy)-6-(N-pyrrolidineethoxy)aniline (synthesized via General Procedures J3-J7) (816 mg; 2 mmol) in ethanol (5 mL) was subjected to General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 520 mg (34%) of Example 330.

MS m/z 776 (M+H) +

›EXAMPLE 331

(3-{2-[1-butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 2-(4-chlorophenyl)ethanol (20.0 mL, 148 mmol), TEA (31.0 mL, 222 mmol) in anhydrous DCM (100 mL) was added dropwise MsCl (12.0 mL, 156 mmol) at 0° C. within 8 min, and stirred at the same temperature for 2 h. The resulting yellow suspension was diluted with DCM (200 mL), washed with cold H 2 O and brine, and dried. Removal of the solvent afforded the mesylate (33.0 g).

A mixture of the mesylate obtained as above (23.6 g, 100 mmol), 2,4-dihydroxybenzaldehyde (16.6 g, 120 mmol) and KHCO 3 (12.0 g, 120 mmol) in anhydrous DMF(150 mL) was heated at 130° C. for 4 h following the general procedure described for disubstitued benzaldehydes. The crude products were purified by flash chromatography (eluting with 10% EtOAc in hexanes), giving 4-(4-chlorophenyl)ethoxysalicylaldehyde (12.5 g) as a white solid.

Methanesulfonyl chloride, General Procedure P2 (2.90 mL, 37.5 mmol) was added dropwise at 0° C. to a stirred solution of 3-diethylaminopropanol (5.75 mL, 38.8 mmol), TEA (7.0 mL, 50.0 mmol) in anhydrous DCM (25 mL), and the mixture was stirred at the same temperature for 1 h, and at rt for an additional 1 h. After the removal of the solvent in vacuo, the solid residue was mixed with the aldehyde formed above (7.0 g, 25.0 mmol), Cs 2 CO 3 (20.4 g, 62.5 mmol) and anhydrous DMSO (100 mL), and the whole mixture was heated at 90° C. for 6 h. following the general procedure described for disubstitued benzaldehydes to obtain oily 2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (11.0 g, ˜100% yield), which solidified upon standing.

To a stirred solution of 2,4,6-trifluoronitrobenzene (5.31 g, 30 mmol), TEA (8.37 mL, 60 mmol) and DMF (50 mL) was added dropwise a solution of n-butylamine (2.96 mL, 30 mmol) in DMF (20 mL) at rt following General Procedure G1 to obtain crude 2-butylamino-4,6-difluoronitrobenzene (9.0 g). This product was mixed with 3-diethylaminopropanol (11.1 mL, 75 mmol) and anhydrous THF (150 mL), and then powdered KOBu t (8.5 g, 75 mmol) was added following General Procedure G2 to afford crude 2-butylamino-4,6-di(3-diethylaminopropoxy)nitrobenzene (15.5 g).

The nitro compound formed above (6.8 g, 15 mmol) dissolved in MeOH (90 mL) was hydrogenated following general procedure H and 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline obtained was used directly for the next step.

Example 331 was formed employing phenylenediamine formed above (848 mg; 2 mmol) and 2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (858; 2.2 mmol) in ethanol (5 mL) following the general procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) to afford 400 mg of Example 331.

MS m/z 792 (M+H) +

›EXAMPLE 332

(3-{2-[1-Butyl-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine

2-butylamino-4,6-difluoronitrobenzene (9.0 g) was mixed with 1-pyrrolidineethanol (8.81 mL, 75 mmol) and anhydrous THF (150 mL), and then powdered KOBu t (8.5 g, 75 mmol) was added following general procedures G1 and G2 described for homo disubstitued phenylenediamine to afford crude 2-butylamino-4,6-di(phinyrrolidineethoxy)nitrobenzene (13.5 g).

The nitro compound formed above (6.3 g, 15 mmol) dissolved in MeOH (90 mL) was hydrogenated following general procedure H and 2-butylamino-4,6-di(pyrrolidineethoxy)aniline obtained was used directly for the next step.

Example 332 was formed employing phenylenediamine formed above (784 mg; 2 mmol) and 2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (858; 2.2 mmol) in ethanol (5 mL) following the general procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 380 mg of Example 332.

MS m/z 760 (M+H) +

›EXAMPLE 333

(3-{1-Butyl-6-(3-diethylamino-propoxy)-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine

A solution of 2,4-difluorobenzaldehyde (2.13 g, 15.0 mmol) in DMF (10 ml) was added dropwise to a precooled (0° C.) solution of sodium 2-pyrrolidinoethoxide in DMF (50 ml), which was made by stirring a mixture of sodium hydride (600 mg, 15.0 mmol, 60% in mineral oil) and N-(2-hydroxyethyl)pyrrolidine (1.72 g, 15.0 mmol). The resulting reaction mixture was warmed to rt and stirred for additional 3 h. To the same reaction flask was introduced potassium carbonate (2.10 g, 15.0 mmol) and 3-fluoro-4-trifluoromethylphenol (2.7 g, 15.0 mmol) and the reaction mixture was heated at 90° C. as described in the General Procedure E for 2-alkoxy-4-aryloxybenzaldehydes. The crude product was purified by silica gel column chromatography using dichloromethane and 5% methanol in dichloromethane as eluent, to give 2-(2-pyrrolidineethoxy)-4-(3-fluoro-4-trifluoromethyl)phenoxybenzaldehyde (2 g) as a brown oil.

MS m/z 399 (M+H) +

Example 333 was formed employing the aldehyde formed above (873 mg; 2.2 mmol) and 2-butylamino-4,6-di(3-diethylaminopropoxy)aniline (848; 2.0 mmol) following the general procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 390 mg of Example 333.

MS m/z 800 (M+H) +

›EXAMPLE 334

{3-[1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine

MsCl (1.4 mL, 18.0 mmol) was added dropwise at 0° C. to a stirred solution of pyrrolidineehanol (1.90 mL, 16.0 mmol), TEA (2.8 mL, 20.0 mmol) in anhydrous DCM (20 mL), and the mixture was stirred at rt for 1 h. After the removal of the solvent in vacuo, the solid residue was mixed with 3,5-difluoro-4-nitrophenol (1.75 g; 10 mmol) and K2CO3 (5.5 g; 40 mmol) following General Procedure F1. The product, 2,6-difluoro-4-(N-pyrrolidineethoxy)nitrobenzene (1.5 g) was used directly

To a stirred solution of 2,6-difluoro-4-(N-pyrrolidineethoxy)nitrobenzene obtained above (1.4 g; 5.1 mmol) and triethylamine (1.4 mL; 10.0 mmol) in DMF (10 mL), a solution of n-butylamine (505 μL; 5.1 mmol) in DMF (3 mL) was added according to General Procedure G1. The crude product, 2-(n-butylamino)-4-(N-pyrrolidineethoxy)-6-fluoronitrobenzene (1.5 g) was used for further transformation without any purification.

A solution of 3-diethylaminopropanol (652 μL; 4.4 mmol) in anhydrous THF 4.4 mL was added with powdered KOBu t (493 mg; 4.4 mmol) and stirred at rt for 5 min. This solution was added dropwise to a stirred solution of 2-(n-butylamino)-4-(N-pyrrolidineethoxy)-6-fluoronitrobenzene (1.32 g; 4.0 mmol) in anhydrous THF (10 mL) according to General Procedure G2. The crude product, 2-(n-butylamino)-4-(N-pyrrolidineethoxy)-6-(N,N-diethylaminopropoxy)nitrobenzene (1.5 g) was used directly.

The nitro compound formed above (1.31 g, 4 mmol) dissolved in MeOH (20 mL) was hydrogenated following general procedure H. The product obtained (1.15 g) was used directly for the next step.

Example 334 was formed employing phenylenediamine formed above (816 mg; 2 mmol) and 2-(2-pyrrolidineethoxy)-4-(3-fluoro-4-trifluoromethyl)phenoxybenzaldehyde (873 mg; 2.2 mmol) in ethanol (5 mL) following general procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 375 mg of Example 334.

MS m/z 784 (M+H) +

›EXAMPLE 335

{3-[2-[1-Butyl-6-(3-diethylamino-propoxy)-4-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-(4-fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-propyl}-diethyl-amine

A solution of 2,4-difluorobenzaldehyde (2.13 g, 15.0 mmol) in DMF (10 ml) was added dropwise to a precooled (0° C.) solution of sodium 3-diethylaminopropoxide in DMF (50 ml), which was made by stirring a mixture of sodium hydride (600 mg, 15.0 mmol, 60% in mineral oil) and 3-diethylaminopropanol (1.97 g, 15.0 mmol). The resulting reaction mixture was warmed to rt and stirred for additional 3 h. To the same reaction flask was introduced potassium carbonate (2.10 g, 15.0 mmol) and 3-fluoro-4-trifluoromethylphenol (2.7 g, 15.0 mmol) and the reaction mixture was heated at 90° C. as described general procedure E. The crude product was purified by silica gel column chromatography using dichloromethane and 5% methanol in dichloromethane as eluent, to give 2-(3-diethylaminopropoxy)-4-(3-fluoro-4-trifluoromethyl)phenoxybenzaldehyde (2.2 g).

Methanesulfonyl chloride (General Procedure P2) (1.55 mL, 20.0 mmol) was added dropwise at 0° C. to a stirred solution of 3-diethylaminopropanol (2.70 mL, 18.0 mmol), TEA (2.8 mL, 20.0 mmol) in anhydrous DCM (30 mL), and the mixture was stirred at rt for 1 h. After the removal of the solvent in vacuo, the solid residue was mixed with 3,5-difluoro-4-nitrophenol (2.65 g; 15 mmol) and K 2 CO 3 (6.9 g; 50 mmol) according to General Procedure F1. The crude product, 2,6-difluoro-4-(3-diethylaminopropoxy)nitrobenzene (3.9 g) was used for further transformation.

To a stirred solution of 2,6-difluoro-4-(3-diethylaminopropoxy)nitrobenzene obtained above (1.9 g; 6.6 mmol) and triethylamine (1.4 mL; 10.0 mmol) in DMF (12 mL), a solution of n-butylamine (656 μL; 6.6 mmol) in DMF (4 mL) was added dropwise at rt within 15 min, and the rest was followed as described in the general methods. The crude product, 2-(n-butylamino)-4-(3-diethylaminopropoxy)-6-fluoronitrobenzene (2.0 g) was used for further transformation without any purification.

A solution of 3-diethylaminopropanol (516 □L; 4.4 mmol) in anhydrous THF 4.4 mL was added with powdered KOBu t (493 mg; 4.4 mmol) and stirred at room temperature for 5 min. This solution was added dropwise to a stirred solution of 2-(n-butylamino)-4-(3-diethylaminopropoxy)-6-fluoronitrobenzene (1.37 g; 4.0 mmol) in anhydrous THF (10 mL) at 0° C. under a N 2 stream. The reaction mixture was maintained at 0° C. for 1 h at which time the reaction was complete the rest was followed as described in the general methods. The crude product, 2-(n-butylamino)-4-(3-diethylaminopropoxy)-6-(N-pyrrolidineethoxy)nitrobenzene (1.6 g) was used for further transformation without any purification.

The nitro compound formed above (1.31 g, 4 mmol) dissolved in MeOH (20 mL) was hydrogenated following the general procedure and 2-(n-butylamino)-4-(N-pyrrolidineethoxy)-6-(N,N-diethylaminopropoxy)aniline (1.15 g) obtained was used directly for the next step reaction without further purification.

Example 335 was formed employing phenylenedimaine formed above (816 mg; 2 mmol) and 2-(3-diethylaminopropoxy)-4-(3-fluoro-4-trifluoromethyl)phenoxybenzaldehyde (910 mg; 2.2 mmol) in ethanol (5 mL) following the general procedure. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 380 mg of Example 335.

MS m/z 800 (M+H) +

›EXAMPLE 336

{3-[2-[1-Butyl-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-(4-fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-propyl}-diethyl-amine

A solution of 2,4-difluorobenzaldehyde (2.13 g, 15.0 mmol) in DMF (10 ml) was added dropwise to a precooled (0° C.) solution of sodium 3-dimethylaminopropoxide in DMF (50 ml), which was made by stirring a mixture of sodium hydride (600 mg, 15.0 mmol, 60% in mineral oil) and 3-dimethylaminopropanol (1.55 g, 15.0 mmol). The resulting reaction mixture was warmed to rt and stirred for additional 3 h. To the same reaction flask was introduced potassium carbonate (2.10 g, 15.0 mmol) and 3-fluoro-4-trifluoromethylphenol (2.7 g, 15.0 mmol) and the reaction mixture was heated at 90° C. as described in General Procedure E for 2-alkoxy-4-aryloxybenzaldehydes. The crude product was purified by silica gel column chromatography using dichloromethane and 5% methanol in dichloromethane as eluent, to give 2-(3-dimethylaminopropoxy)-4-(3-fluoro-4-trifluoromethyl)phenoxybenzaldehyde (2.0 g).

Example 336 was formed employing the aldehyde formed above (823 mg; 2.2 mmol) and 2-butylamino-4,6-di(pyrrolidineethoxy)aniline (784; 2.0 mmol) in ethanol (5 mL) following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 380 mg of Example 336.

MS m/z 784 (M+H) +

›EXAMPLE 337

{3-[3-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-7-(2-pyrrolidin-1-yl-ethoxy)-3H-benzimidazol-5-yloxy]-propyl}-diethyl-amine

Example 337 was formed employing the aldehyde formed above (823 mg; 2.2 mmol) and 2-butylamino-4,6-di(pyrrolidineethoxy)aniline (784; 2.0 mmol) in ethanol (5 mL) following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 380 mg of Example 337.

MS m/z 759 (M+H) +

›EXAMPLE 338

(3-{2-[1-Butyl-4-(3-diethylamino-propoxy)-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine

2-(3-diethylaminopropoxy)-4-[2-(4-chlorophenyl)ethoxy]benzaldehyde (858; 2.2 mmol) and 2-(n-butylamino)-4-(N-pyrrolidineethoxy)-6-(N,N-diethylaminopropoxy)aniline (816 mg; 2 mmol) were condensed to form the benzimidazole following General Procedure K. The crude product was purified by silica gel column chromatography using 10% MeOH in DCM with a gradual increment of triethylamine (0.2 to 1.0%) as eluent to afford 390 mg of Example 338.

MS m/z 776 (M+H) +

The following Examples were synthesized according to the Methods employed for Examples 327-338;

›EXAMPLE 393

(4-benzyloxy-benzyl)-[1-butyl-6-(3-diethylaminopropoxy)-1-H-benzimidazol-2-ylmethyl]-hexyl-amine

To 2-butylamino-4-(3-diethylaminopropoxy)aniline (3.44 g; 11.7 mmol) and BOC-glycine (2.46 g; 14.1 mmol) in DCM (20 mL) was added DCC (2.90 g; 14.1 mmol) and the reaction mixture was stirred for 4 h. The solid was removed by filtration and the filtrate was concentrated to afford the desired product. The crude product was used for further transformation without any purification.

To the product (11.7 mmol) obtained above in dioxane (7.5 mL) was added acetic acid (2.5 mL) and the reaction mixture was heated at 80° C. until the reaction was complete. Saturated sodium bicarbonate was added and the mixture was extracted with EtOAc. The combined organic layer was washed with water and brine, dried over sodium sulfate. Evaporation of the solvent in vacuo afforded desired 1-butyl-2-boc-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole. The product obtained was treated with 4 N HCl in dioxane according to General Procedure H to give 1-butyl-2-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazble hydrochloride.

To 1-butyl-2-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole (1.0 mmol) in DCM (8 mL) were added Et 3 N (3.0 mmol) and 4-benzoxybenzaldehyde (1.0 mmol) and the mixture was stirred for 4 h, then NaBH(OAc) 3 (4.0 mmol) was added and stirred for another 4 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc. The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (1% to 10%) as eluent to afford 1-butyl-2-(4-benzyloxy-benzyl)-aminomethyl-6-(3-diethylaminopropoxy)-1-H-benzimidazole.

To 1-butyl-2-(4-benzyloxy-benzyl)-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole (16 mg, 0.03 mmol) in DCM (2 mL) were added hexanal (8.3 mg, 0.083 mmol) and the mixture was stirred for 10 min, then NaBH(OAc) 3 (32 mg, 0.15 mmol) was added and stirred for 3 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc (3×10 mL). The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (1% to 5%) as eluent to afford 14 mg of Example 393.

MS m/z 613 [M+H] +

›EXAMPLE 394

(4-benzyloxy-benzyl)-[1-butyl-6-(3-diethylaminopropoxy)-1-H-benzimidazol-2-ylmethyl]-isobutyl-amine

To 1-butyl-2-(4-benzyloxy-benzyl)-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole (16 mg, 0.03 mmol) in DCM (2 mL) were added isbutrylaldehyde (8.6 mg, 0.10 mmol) and the mixture was stirred for 10 min, then NaBH(OAc)3 (32 mg, 0.15 mmol) was added and stirred for 3 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc. The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (1% to 5%) as eluent to afford 12 mg of Example 394.

MS m/z 585 [M+H] +

›EXAMPLE 395

[3-(2-[(4-benzyloxy-benzyl)-cyclopentylmethyl-amino]-methyl}-3-butyl-3-H-benzimidazol-5-yloxy)-propyl]-diethylamine

To 1-butyl-2-(4-benzyloxy-benzyl)-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole (16 mg, 0.03 mmol) in DCM (2 mL) were added cyclopentyl carboxaldehyde (11 mg, 0.10 mmol) and the mixture was stirred for 10 min, then NaBH(OAc)3 (32 mg, 0.15 mmol) was added and stirred for 3 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc (3×10 mL). The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (1% to 5%) as eluent to afford 8.0 mg of Example 395.

MS m/z 611 [M+H] +

›EXAMPLE 396

N-(4-benzyloxy-benzyl)-N-[1-butyl-6-(3-diethylaminopropoxy)-1-H-benzimidazol-2-ylmethyl]-benzamide

To 1-butyl-2-(4-benzyloxy-benzyl)-aminomethyl-6-(3-diethylaminopropxy)-H-benzimidazole (32 mg, 0.06 mmol) in DCM (3 mL) were added benzoyl chloride (34 mg, 0.24 mmol), TEA (24 mg, 0.24 mmol), DMAP (catalytic amount) and the mixture was stirred for 12 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc (3×10 mL). The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (0 to 1%) as eluent to afford 30 mg of Example 396.

MS m/z 633 [M+H] +

›EXAMPLE 397

(3-{3-butyl-2-[(dibenzylamino)-methyl]-3H-benzimidazol-5-yloxy)-propyl]-diethyl-amine

To 1-butyl-2-aminomethyl-6-(3-diethylaminopropxy)-1-H-benzimidazole (15 mg, 0.034 mmol) in DCM (2 mL) were added Et 3 N (0.10 mmol) and benzaldehyde (180 mg, 0.17 mmol) and the mixture was stirred for 10 min, then NaBH(OAc) 3 (72 mg, 0.34 mmol) was added and stirred for 3 h, then sodium bicarbonate was added and the mixture was extracted with EtOAc. The combined organic layer was washed with brine, and dried over sodium sulfate. The crude product was purified by silica gel column chromatography using DCM with a gradual increment of MeOH (1% to 2%) as eluent to afford 10 mg of Example 397.

MS m/z 513 [M+H] +

The following Examples were synthesized according to the Methods employed for Examples 393-397;

›EXAMPLE 404

{3-[4-(2-butyl-4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O and extracted with EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene.

The N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg), according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-alkoxyaniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion, according to General Procedure Q1. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone.

To a stirred solution of the 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 2.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by chromatography (Silica gel).

To a stirred solution of the N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.2 eq., 2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 6 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (1.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of valeryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.6 mmol) in acetic acid (4 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel (yield: 270 mg).

MS m/z 561 (M+H) + :

1 H NMR: δ 7.85 (s, 1H), 7.71 (d, 2H), 7.56 (d, 2H), 7.32 (m, 4H), 7.24 (d, 2H), 7.06 (d, 2H), 4.25 (t, 2H), 3.43 (t, 2H), 3.35 (m, 6H), 3.12 (t, 2H), 2.97 (t, 2H), 2.31 (m, 2H), 1.65 (m, 2H), 1.41 (t, 6H), 1.37 (m, 2H), 0.85 (t, 3H) ppm.

›EXAMPLE 405

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-isobutyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation without any purification, or after purifying using silica gel column chromatography.

The N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-alkoxyaniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (1.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (3.0 mmol) was added. 4-chlorophenethyl mesylate (1.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched by removing solvent in vacuuo and treating the residue with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (20 ml) and washed with H 2 O (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation without any purification or after purifying using silica gel column chromatography.

To a stirred solution of the 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of the N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.2 eq, 2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq 6 mmol) was added, followed by a slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (1.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained from 2-4% MeOH/DCM.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq, 6 mmol) was added, followed by a slow addition of isovaleryl chloride (3 eq, 6 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (2 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (Yield: 390 mg).

MS m/z 560 (M+H) +

1 H NMR: δ 7.86 (s, 1H), 7.65 (d, 2H), 7.59 (d, 2H), 7.31 (m, 4H), 7.23 (d, 2H), 7.13 (d, 2H), 4.51 (m, 2H), 3.42 (t, 2H), 3.31 (m, 6H), 3.05 (t, 2H), 2.87 (t, 2H), 2.31 (m, 2H), 1.95 (m, 1H), 1.49 (t, 6H), 0.86 (d, 6H) ppm.

›EXAMPLE 406

[3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL), and 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the product was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). T

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (5 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (6 mmol, 1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a solution of 4-chlorophenoxy aniline (1 eq, 5 mmol) in anhydrous DMF (10 mL), DIEA (3 eq 15 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (5 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM.

To a stirred solution of 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone (2 mmol) in anhydrous DCM (8 mL) at 0° C., TEA (3 eq, 6 mmol) was added, followed by a slow addition of valeryl chloride (3 eq, 6 mmol). The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion as indicated by TLC or HPLC, according to General Procedure R3. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (2 mmol) in acetic acid (8 mL), ammonium acetate (20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel elutiopn with 4-6% MeOH/DCM) (yield 424 mg).

MS m/z 532 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.68 (d, 2H), 7.34 (d, 2H), 7.28 (d, 2H), 7.14 (s, 1H), 7.07 (d, 2H), 7.01 (d, 2H,), 6.89 (d, 2H) 4.04 (t, 2H), 2.64-2.78 (m, 8H), 1.99 (m, 2H), 1.64 (m, 2H), 1.30 (m, 2H), 1.09 (t, 6H), 0.83 (t, 3H) ppm.

›EXAMPLE 407

1-[4-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-butyl]-piperazine

To a stirred solution of 4-benzyloxyacetophenone (7.0 mmol) in anhydrous DCM (30.0 mL) and MeOH (5.0 mL) at rt, pyridinium bromide perbromide (1.1 eq.) was added. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate. The solvent was then removed in vacuuo to give a white solid. The alpha-bromoacetophenone was used for further transformation without further purification.

To a stirred solution of 4-(4-fluoro-3-trifluoromethyl-phenoxy)-aniline (1.64 mmol) in anhydrous DMF (30 mL) DIEA (3 eq) was added, followed by slow addition of the alpha-bromoacetophenone described above (2 eq), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC and HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography on silica gel (elution with 5-20% EtOAc/Hexane).

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol). The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion as indicated by TLC and HPLC, according to General Procedure R3. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel (elution with 5-15% EtOAc/Hexane). MS: m/z 562 (M+H) + )

The benzyl imidazole from above was dissolved in MeOH (20 mL), and Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under hydrogen atmosphere using a balloon, according to General Procedure H. The catalyst was removed by filtration. The solvent was removed in vacuuo, and the crude phenol (MS: m/z 472 (M+H) + ) was used directly.

To a stirred solution of the phenol (0.16 mmol) obtained above in anhydrous DMF (5 mL) solid sodium hydride (60% dispersion in oil; 1.0 mmol) was added in portions. After the addition, a solution of 4-bromobutyl methanesulfonate (0.2 mmol) (prepared as described earlier) in anhydrous THF (2 mL) was added to the reaction mixture. The reaction was then allowed to proceed at rt. Upon completion of the reaction, piperazine (5.0 eq) was added. The mixture was stirred overnight. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Product was purified by column chromatography on silica gel (elution with 5-10% MeOH/DCM) (yield 54.0 mg)

MS m/z 612 (M+H) + :

›EXAMPLE 408

4-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-1-methyl-piperidine

To a stirred solution of 4-benzyloxyacetophenone (7.0 mmol) in anhydrous DCM (30.0 mL) and MeOH (5.0 mL) at rt, pyridinium bromide perbromide (1.1 eq.) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate. The solvent was then removed in vacuuo to give a white solid. The alpha-bromoacetophenone was used for further transformation without further purification.

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS: m/z 562 (M+H) + )

The above product was dissolved in MeOH (20 mL), and Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under hydrogen atmosphere using a balloon, according to General Procedure T2. The Pd/C was removed by filtration. The solvent was removed in vacuuo, and the crude 4-(1-{4-[4-fluoro-3-(trifluoromethyl)phenoxy]phenyl}-2-butyl-1H-imidazol-4-yl)phenol (MS: m/z 472 (M+H) + ) was used directly.

A stirred solution of the 4-(1-{4-[4-fluoro-3-(trifluoromethyl)phenoxy]phenyl}-2-butyl-1H-imidazol-4-yl)phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol), added in portions. The mesylate of 1-methylpiperidin-4-ol (1.5-2.0 eq) was then added to the reaction mixture, which was heated at 90° C. overnight, according to General Procedure T3. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography in 5-10% MeOH/DCM (yield 14 mg).

MS m/z value (M+H) + : 569

1 H NMR (CDCl 3 ): δ7.70 (d, 2H), 7.20-7.35 (m, 5H), 7.14 (s, 1H), 7.08 (d, 2H), 6.92 (d, 2H), 4.4 (bs, 1H), 1.0 3.05 (m, 17H) ppm.

›EXAMPLE 409

1-[5-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-pentyl]-piperazine

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 5-15% EtOAc/Hexane.

MS: m/z 562 (M+H) + )

The above product was dissolved in MeOH (20 mL), and Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under hydrogen atmosphere using a balloon, according to General Procedure H. The Pd/C was removed by filtration. The solvent was removed in vacuuo, and the crude phenol (MS: m/z 472 (M+H) + ) was used for further transformation.

To a stirred solution of the imidazole (0.16 mmol) obtained above in anhydrous DMF (5 mL) solid sodium hydride (60% dispersion in oil; 1.0 mmol) was added in portions. After the addition, a solution of 5-bromopentyl methanesulfonate (0.2 mmol) anhydrous THF (2 mL) was added to the reaction mixture. The reaction was then allowed to proceed at rt. Upon completion of the reaction, piperazine (100 mg) added. The mixture was stirred overnight. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure product was obtained after chromatography on slilca gel (elution with 5-10% MeOH/DCM) (yield 36.0 mg).

MS m/z 626 (M+H) + :

›EXAMPLE 410

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation without any purification, or after purifying using silica gel column chromatography.

The N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine, which was used directly for further transformation without further purification.

To a stirred solution of the 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidinone hydrotribromide (1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

The 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone obtained as above (1 mmol) was dissolved in formic acid (2 mL) and treated with ammonium formate (20 mmol). The resulting mixture was heated to 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel (elution with 4-6% MeOH/DCM) (yield 161 mg).

MS m/z 504 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.77 (s, 1H), 7.73 (d, 2H), 7.38 (s, 1H), 7.10-7.35 (m, 6H), 6.97 (d, 2H), 6.92 (d, 2H), 4.17 (t, 2H), 4.06 (broad t, 2H), 3.07 (t, 2H), 2.81 (broad q, 4H) 1.95-2.15 (broad m, 4H), 1.17 (t, 6H) ppm.

›EXAMPLE 411

{3-[3-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 3-nitrophenol (2 mmol) in DMF (6 mL) at rt, solid potassium carbonate (4 mmol) was added. A solution of the mesylate of N,N-diethylaminopropanol (2.2 mmol) in DMF (2 mL) was then added to the reaction mixture and heated to 80° C. until completion, according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine. The crude product was used directly for further transformation.

The N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine (1 mmol) was dissolved in MeOH (5 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine, which was used directly for further transformation without further purification.

To a stirred solution of N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine (1 mmol) in anhydrous DMF (3 mL), DIEA (3 mmol) was added followed by a slow addition of 1-bromo-4′-(4-chlorophenethoxy)acetophenone (0.8 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography on silica gel (elutiion with 2-4% MeOH/DCM).

The 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone obtained as above (0.5 mmol) was dissolved in formic acid (1 mL) and treated with ammonium formate (10 mmol). The resulting mixture was heated to 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel (elution with 4-6% MeOH/DCM).

MS m/z value (M+H) + : 504

1 H NMR (CDCl 3 ): δ7.89 (s, 1H), 7.74 (d, 2H), 7.47 (s, 1H), 7.30-7.10 (m, 7H), 6.92 (d, 2H) 6.85 (t, 1H) 4.10-4.20 (m, 4H), 3.00-3.20 (m, 6H), 2.31 (broad, 2H), 1.36 (t, 6H) ppm.

›EXAMPLE 412

[3-(4-{1-[4-(4-tert-butyl-phenoxy)-phenyl]-1H-imidazol-4-yl)-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of potassium 4-tert-butyl-phenoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of KOBu t in THF) was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuo and the reaction mixture was treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered. The solvent was removed in vacuuo to afford the desired 4-alkoxyaniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid K 2 CO 3 (8.0 mmol) was added. The mesylate of N,N-diethyaminopropanol (prepared from the corresponding alcohol and methanesulfonyl chloride, 2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified using silica gel column chromatography (elution with 2-3% MeOH/DCM).

To a stirred solution of the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (1 mmol) described above 48% HBr (3 eq, 3 mmol) in DMSO (4 mL) was added. The reaction mixture was heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was neutralized with 2N sodium hydroxide solution and the product was isolated in EtOAc. The combined organic layers were washed with H 2 O (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude ketoaldehyde was used for further transformation.

To a stirred solution of the ketoaldehyde (1 mmol) in AcOH (5 mL) 4-tert-butyl-phenoxy aniline (1.2 eq., 1.2 mmol), formaldehyde (excess, ˜30 eq.) and ammonium acetate (excess, ˜30 eq.) were added, according to General Procedure R4. The reaction mixture was heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was neutralized with saturated sodium bicarbonate solution and the product was isolated in EtOAc. Usual extractive work up gave the desired product, which was purified by column chromatography on silica gel (elution with 3-4% MeOH/DCM) (Yield 150 mg).

MS: m/z 498 (M+H) +

1 H NMR (CDCl 3 ): δ7.64 (s, 1H), 7.39 (d, 2H), 7.12 (s, 1H), 7.06 (d, 2H) 7.02 (d, 2H) 6.97 (m, 2H) 6.79 (d, 2H), 3.98 (t, 2H), 2.66 (m, 6H), 2.02 (m, 2H), 1.31 (s, 9H), 1.08 (t, 6H) ppm.

›EXAMPLE 413

[3-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium 4-fluoro-3-trifluoromethyl-phenoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1 M solution of potassium t-butoxide in THF) was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the reaction mixture was treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene. The crude product could be used directly for further transformation.

The 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered. The solvent was removed in vacuuo to afford the desired 4-alkoxyaniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (8.0 mmol) was added. The mesylate of N,N-diethyaminopropanol (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified using silica gel column chromatography. Pure product was obtained after elution with 2-3% MeOH/DCM. (yield 50-60%)

To a stirred solution of the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (1 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq, 1.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate and the product was isolated in EtOAc. The combined organic layers were washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of the 4-fluoro-3-trifluoromethyl-phenoxy aniline (1.2 eq., 1.2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 3 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (1.0 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 3 mmol) was added, followed by slow addition of valeryl chloride (2 eq., 2.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained after elution with 4-6% MeOH/DCM (Yield 175 mg).

MS m/z 584 (M+H) +

›EXAMPLE 414

diethyl-[3-(4-{1-[4-(4-trifluoromethoxy-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of potassium 4-trifluoromethoxy-phenoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of KOBu t in THF) was added dropwise under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuo and the reaction mixture was treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-alkoxyaniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid K 2 CO 3 (8.0 mmol) was added. The mesylate of N,N-diethyaminopropanol (prepared from the corresponding alcohol and methanesulfonyl chloride, 2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), H 2 O (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM.

To a stirred solution of the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (1 mmol) described above 48% HBr (3 eq, 3 mmol) in DMSO (4 mL) was added. The reaction mixture was heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was neutralized with saturated sodium bicarbonate solution and the product was isolated in EtOAc. The combined organic layers were washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude ketoaldehyde was used for further transformation.

To a stirred solution of the ketoaldehyde (1 mmol) in AcOH (5 mL), 4-trifluoromethoxy-phenoxy-aniline (1.2 eq., 1.2 mmol), formaldehyde (excess, ˜30 eq.) and ammonium acetate (excess, ˜30 eq.) were added, according to General Procedure R4. The reaction mixture was heated to 80° C. until completion, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was neutralized with saturated sodium bicarbonate solution and the product was isolated in EtOAc. Usual extractive work up with EtOAc gave the desired product, which was purified by column chromatography on silica gel, elution with 3-4% MeOH/DCM) (Yield 130 mg).

MS: m/z 526 (M+H) +

1 H NMR (CDCl 3 ): δ7.91 (s, 1H), 7.41 (d, 2H), 7.28 (d, 2H), 7.05 (d, 2H), 6.98 (m, 4H) 6.81 (d, 2H) 3.99 (t, 2H), 2.96 (m, 6H), 2.18 (m, 2H), 1.22 (t, 6H) ppm.

›EXAMPLE 415

[3-(4-{2-butyl-1-[4-(3,4-dichloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The product from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM).

3,4-Dichlorophenol (10 mmol) was dissolved in 15 ml of anhydrous DMF and potassium carbonate (30 mmol) was added with stirring at rt. 4-Fluoronitrobenzene (10 mmol) was added to this mixture, which was then heated under reflux at 80° C. for 18 h. The reaction was quenched with 30 ml of water and 30 ml of sodium bicarbonate, extracted with EtOAc (3×50 ml) and washed with sodium bicarbonate and water. The EtOAc layer was dried over anhydrous sodium sulfate and filtered, after which the solvent was removed in vacuuo.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (30 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(3,4-dichlorophenoxy)aniline, which was used directly for further transformation without further purification

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (2 mmol) in anhydrous MeOH (6 mL) at 0° C., pyrrolidone hydrotribromide (2.4 mmol, 1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a solution of 4-(3,4-dichlorophenoxy) aniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM.

To a stirred solution of alkylated aniline described above (1 mmol) in anhydrous DCM (4 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by a slow addition of valeryl chloride (3 eq, 3 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1 mmol) in acetic acid (4 mL), ammonium acetate (excess, ˜20 eq) was added according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography on silica gel (elution with 4-6% MeOH/DCM) (yield 170 mg).

MS m/z 567 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 7.7 (d, 2H), 7.3 (m, 3H), 6.9-7.1 (m, 7H), 4.0 (t, 2H), 2.7 (m, 8H), 2.0 (m, 2H), 1.6 (m, 2H), 1.3 (m, 2H), 1.1 (t, 6H), 0.8 (t, 3H) ppm.

›EXAMPLE 416

[3-(4-{2-cyclobutyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (20 mmol), 4-fluoro-3-trifluoromethylphenol (22 mmol) in DMF (50 mL) at rt, solid potassium carbonate (60 mmol) was added and the reaction mixture was heated to 90° C. for 5 h (monitored by TLC), according to General Procedure L1. After cooling to rt, the reaction mixture was poured into cold H 2 O (60 mL). The resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with H 2 O (2×40 mL) and brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo to afford the desired 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene. The crude product was used directly for further transformation without further purification.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or LC-MS, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford 4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline, which was used directly for further transformation without purification (overall yield: 95%).

To a stirred solution of ice-cold 3-diethylaminopropanol (63 mmol) and TEA (80 mmol) dissolved in anhydrous DCM (50 mL), methanesulfonyl chloride (60 mmol) was added dropwise and the reaction mixture was stirred for 2 h at 0° C., followed by additional 1 h at rt. After the removal of the solvents in vacuuo, the crude mesylate was dissolved in DMF (100 mL). 4-Hydroxyacetophenone (40 mmol) and cesium carbonate (100 mmol) were added, and the mixture was heated with stirring at 90° C. for 18 h (monitored by LC-MS). After cooling to rt, the reaction was quenched with cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 ml), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield: 75%).

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (4 mmol) in MeOH (10 mL) at rt, pyrrolidone hydrotribromide (4.8 mmol) was added, according to General Procedure R1. The reaction mixture was stirred at rt for 1 h (monitored by LC-MS). The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was directly used for further transformation.

To a stirred solution of 4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline (4.8 mmol) dissolved in anhydrous DMF (10 mL), DIEA (12 mmol) was added followed by a slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone obtained above (˜4 mmol), according to General Procedure R2. The reaction mixture was stirred at rt and under nitrogen until completion (˜5 h), as indicated by LC-MS. The reaction was quenched with saturated sodium bicarbonate (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×40 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield: 64%).

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added followed by a slow addition of cyclobutanecarbonyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

To a stirred solution of the amide described above (˜0.2 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜30 eq) was added according to General Procedure R4. The reaction mixture was stirred at 100° C. for 2-5 h (as monitored by LC-MS). The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate. The resulting mixture was extracted with EtOAc (3×50 mL). The combined EtOAc extracts were washed with brine (3×20 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the pure product was obtained by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield 64 mg).

MS m/z 582 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ1.05 (t, 6H), 1.90-2.20 (m, 6H), 2.56 (m, 2H), 2.58 (q, 4H), 2.66 (t, 2H), 3.44 (m, 1H), 4.02 (t, 2H), 6.91 (d, 2H), 7.05 (d, 2H), 7.14 (s, 1H), 7.22-7.26 (m, 3H), 7.31 (d, 2H), 7.72 (d, 2H) ppm.

›EXAMPLE 417

[3-(4-{2-cyclopentyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (20 mmol), 4-fluoro-3-trifluoromethylphenol (22 mmol) in DMF (50 mL) at rt, solid potassium carbonate (60 mmol) was added, and the reaction mixture was heated to 90° C. for 5 h (monitored by TLC), according to General Procedure L1. After cooling to rt, the reaction mixture was poured into cold H 2 O (60 mL). The resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with H 2 O (2×40 mL) and brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo to afford the desired 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene. The crude product was used directly for further transformation without further purification.

To a stirred solution of ice-cold 3-diethylaminopropanol (63 mmol) and TEA (80 mmol) dissolved in anhydrous DCM (50 mL) was added dropwise methanesulfonyl chloride (60 mmol), and the reaction mixture was stirred for 2 h at 0° C. and followed by additional 1 h at rt. After the removal of the solvents in vacuuo, the crude mesylate was dissolved in DMF (100 mL). 4-Hydroxyacetophenone (40 mmol) and cesium carbonate (100 mmol) were added, and the mixture was heated with stirring at 90° C. for 18 h (monitored by LC-MS). After cooling to rt, the reaction was quenched with cold H 2 O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 ml), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield: 75%).

To a stirred solution of 4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline (4.8 mmol) dissolved in anhydrous DMF (10 mL), DIEA (12 mmol) was added, followed by a slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone obtained above (˜4 mmol), according to General Procedure R2. The reaction mixture was stirred at rt and under nitrogen until completion (˜5 h), as indicated by LC-MS. The reaction was quenched with saturated sodium bicarbonate (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×40 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield: 64%).

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of cyclopentanecarbonyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

To a stirred solution of the amide described above (˜0.2 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜30 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. for 2-5 h (as monitored by LC-MS). The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate. The resulting mixture was extracted with EtOAc (3×50 mL). The combined EtOAc extracts were washed with brine (3×20 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the pure product was obtained by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (overall yield: 60-70%) (yield 77 mg).

MS m/z 596 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 1.03-2.00 (m, 11H), 1.07 (t, 6H), 2.59 (q, 4H), 2.65 (t, 2H), 4.03 (t, 2H), 6.91 (d, 2H), 7.08 (d, 2H), 7.14 (s, 1H), 7.24-7.27 (m, 3H), 7.33 (d, 2H), 7.71 (d, 2H) ppm.

›EXAMPLE 418

[3-(4-{2-cyclohexyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of cyclohexanecarbonyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 610 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ1.02-2.00 (m, 13H), 1.06 (t, 6H), 2.60 (q, 4H), 2.67 (t, 2H), 4.02 (t, 2H), 6.90 (d, 2H), 7.07 (d, 2H), 7.09 (s, 1H), 7.22-7.26 (m, 3H), 7.30 (d, 2H,), 7.69 (d, 2H) ppm.

›EXAMPLE 419

diethyl-[3-(4-{1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-propyl]-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of isovaleryl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 584 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ0.86 (d, 6H) 1.07 (t, 6H), 1.97 (m, 2H), 2.04 (m, 1H), 2.55 (d, 2H), 2.61 (q, 4H), 2.69 (t, 2H), 4.03 (t, 2H), 6.90 (d, 2H), 7.07 (d, 2H), 7.14 (s, 1H), 7.22-7.25 (m, 3H), 7.30 (d, 2H), 7.70 (d, 2H) ppm.

›EXAMPLE 420

[3-(4-{2-but-3-enyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of pent-4-enoyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 582+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 1.12 (t, 6H), 2.03 (m, 2H), 2.45 (t, 2H), 2.63 (t, 2H,), 2.73 (q, 4H), 2.77 (t, 2H), 4.04 (t, 2H), 4.94 (dd, 1H), 5.00 (dd, 1H), 5.79 (m, 1H), 6.90 (d, 2H), 7.07 (d, 2H), 7.15 (s, 1H), 7.24-7.25 (m, 3H), 7.32 (d, 2H, 7.70 (d, 2H) ppm.

›EXAMPLE 421

[3-(4-{2-tert-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of pivaloyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 584 (M+H) +

1 H NMR (400 MHz, CDCl 3 ): δ1.09 (t, 6H), 1.24 (s, 9H), 1.99 (m, 2H), 2.64 (q, 4H), 2.72 (t, 2H), 4.02 (t, 2H), 6.89 (d, 2H), 7.02 (s, 1H), 7.03 (d, 2H), 7.23-7.25 (m, 3H), 7.35 (d, 2H), 7.69 (d, 2H) ppm.

›EXAMPLE 422

diethyl-[3-(4-{2-(4-fluoro-phenyl)-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of 4-fluorobenzoyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 622 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ1.11 (t, 6H), 2.01 (m, 2H), 2.67 (q, 4H), 2.75 (t, 2H), 4.05 (t, 2H), 6.93 (d, 2H), 6.98-7.26 (m, 7H), 7.01 (d, 2H), 7.33 (s, 1H), 7.43 (d, 2H), 7.44 (d, 1H), 7.78 (d, 2H) ppm.

›EXAMPLE 423

[3-(4-{1-[4-(3,5-bis-trifluoromethyl-phenoxy)-phenyl]-2-butyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

3,5-bis-trifluoromethylphenol (10 mmol) was dissolved in 15 ml of anhydrous DMF and potassium carbonate (30 mmol) was added with stirring at rt. 4-Fluoronitrobenzene (10 mmol) was added to this mixture, which was then heated under reflux at 80° C. for 18 h. The reaction was quenched with 30 ml of water and 30 ml of sodium bicarbonate, extracted with EtOAc (3×50 ml) and washed with sodium bicarbonate and water. The EtOAc layer was dried over anhydrous sodium sulfate and filtered, after which the solvent was removed in vacuuo.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (30 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(3,5-bis-trifluoromethyl)phenoxyaniline, which was used directly for further transformation without further purification (yield 80%).

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (2 mmol) in anhydrous MeOH (6 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a solution of 4-(3,5-bis-trifluoromethyl)phenoxyaniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Removal of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield 50%).

To a stirred solution of the amide described above (1 mmol) in acetic acid (4 mL), ammonium acetate (20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield 139 mg).

MS m/z 635 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 7.7 (d, 2H), 7.3 (m, 3H), 7.1 (m, 5H), 6.9 (d, 2H), 4.0 (t, 2H), 2.6-2.8 (m, 8H), 2.0 (m, 2H), 1.6 (m, 2H), 1.3 (m, 2H), 1.1 (t, 6H), 0.8 (t, 3H) ppm.

›EXAMPLE 424

(3-{4-[1-(4-benzyloxy-phenyl)-2-butyl-1H-imidazol-4-yl]-phenoxy}-propyl)-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the product was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

To a solution of 4-benzyloxyaniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield 56%).

MS m/z 513 (M+H) + ;

1 H NMR (CDCl 3 ): δ 7.68 (d, 2H), 7.40 (m, 5H), 7.23 (d, 2H), 7.11 (s, 1H), 7.05 (d, 2H), 6.89 (d, 2H), 5.12 (s, 2H), 4.02 (t, 2H), 2.62-2.73 (m, 8H), 1.98 (m, 2H), 1.63 (m, 2H), 1.28 (m, 2H), 1.07 (t, 6H), 0.82 (t, 3H) ppm.

›EXAMPLE 425

{3-[4-(2-tert-butyl-4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of pivaloyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 561 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.23-7.25 (m, 6H), 6.98 (s, 1H), 6.84 (m 4H), 4.15 (t, 2H), 4.08 (t, 2H), 3.05 (t, 2H), 2.85 (m, 6H), 2.16 (s, 9H), 2.05 (m, 2H), 1.19 (t, 6H) ppm.

›EXAMPLE 426

[3-(4-{2-butyl-1-[4-(3-fluoro-4-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4-(3-fluoro-4-trifluoromethyl-phenoxy)-aniline (1.64 mmol) in anhydrous DMF (30 mL) DIEA (3 eq) was added, followed by slow addition of the alpha-bromoacetophenone described above (2 eq), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC and HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained from 5-20% EtOAc/Hexane (yield˜50-60%).

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 5-15% EtOAc/Hexane (yield 80%). (MS: m/z 562 (M+H) + )

The above product was dissolved in MeOH (20 mL), and Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under hydrogen atmosphere using a balloon, according to General Procedure H. The Pd/C was removed by filtration. The solvent was removed in vacuuo, and the crude phenol (MS: m/z 472 (M+H) + ) was used for further transformation.

To a stirred solution of the phenol (1.0 eq) obtained above in anhydrous DMF (5.0 mL) solid sodium hydride (60% dispersion in oil; 1.0 mmol) was added in portions. After the addition, the requisite alkylhalide or the mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride) (1.5-2.0 eq) was added to the reaction mixture. The reaction mixture was heated at 90° C. overnight. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure product was obtained from 5-10% MeOH/DCM (yield 65.0 mg).

MS m/z 557 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.70 (d, 2H), 7.20-7.35 (m, 5H), 7.14 (s, 1H), 7.08 (d, 2H), 6.92 (d, 2H), 4.02 (t, 2H), 2.66 (t, 2H), 2.47 (t, 2H), 2.26 (s, 6H), 1.96 (m, 2H), 1.64 (m, 2H), 1.29 (m, 2H) 0.9 (t, 3H) ppm.

›EXAMPLE 427

diethyl-[3-(4-{4-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-amine

To a stirred solution of N-[3-(4-aminophenoxy)propyl]-N,N-diethylamine (1.2 eq, 2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq 6 mmol) was added, followed by a slow addition of 2-bromo-1-(4-bromophenyl)ethanone (1.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained from 2-4% MeOH/DCM (yield˜50-60%).

To a stirred solution of 1-(4-bromophenyl)-2-({4-[3-(diethylamino)propoxy]phenyl}amino)ethanone (2 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield 40-50%).

To a solution of N-(3-{4-[4-(4-bromophenyl)-1H-imidazol-1-yl]phenoxy}propyl)-N,N-diethylamine (0.07 mmol) in pyridine (1 mL), copper powder was added (0.14 mmol), followed by potassium carbonate (0.35 mmol) and 4-fluoro-3-methylphenol (0.14 mmol). The mixture was heated at 110° C. overnight, then diluted with H 2 O (2 mL) and extracted with EtOAc (3×2 mL). The combined organic extract was dried over sodium sulfate, filtered and concentrated to an oil, which was purified by column chromatography (Silica gel). The pure product was obtained from 1-6% MeOH/DCM.

MS m/z 528 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 7.86-7.78 (m, 3H), 7.54-7.44 (m, 2H), 7.38-7.34 (m, 2H), 7.28-7.24 (m, 1H), 7.20-7.16 (m, 2H), 7.06-6.80 (m, 3H), 4.10 (t, 2H), 2.80-2-60 (m, 6H), 2.10-2.00 (m, 2H), 1.30 (t, 3H), 1.10 (t, 3H) ppm.

›EXAMPLE 428

(3-{4-[4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-(4-fluoro-phenyl)-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 4-fluorobenzoyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 598 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.76 (d, 2H), 7.41 (m, 2H), 7.26 (m, 2H), 7.21 (d, 2H), 7.16 (d, 2H), 7.01 (m, 7H), 4.16 (t, 2H), 4.05 (t, 2H), 3.05 (t, 2H), 2.97 (m, 6H), 2.18 (m, 2H), 1.24 (t, 6H) ppm

›EXAMPLE 429

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-cyclopropyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of cyclopropanecarbonyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 544 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.65 (d, 2H), 7.31 (m, 4H), 7.21 (d, 2H), 7.18 (s, 1H), 6.98 (d, 2H), 6.88 (d 2H), 4.18 (t, 2H), 4.08 (t, 2H), 3.07 (t, 2H), 3.12 (m, 1H) 2.78 (m, 6H), 2.57 (m, 4H), 2.06 (m, 2H), 1.12 (t, 6H) ppm

›EXAMPLE 430

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-cyclopentyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of cyclopentanecarbonyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 572 (M+H) + :

›EXAMPLE 431

[3-(4-{4-[4-(biphenyl-4-yloxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of N-[3-(4-aminophenoxy)propyl]-N,N-diethylamine (1.2 eq, 2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq 6 mmol) was added, followed by a slow addition of the 2-bromo-1-(4-bromophenyl)ethanone described above (1.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained from 2-4% MeOH/DCM (yield˜50-60%).

To a solution of the N-(3-{4-[4-(4-bromophenyl)-1H-imidazol-1-yl]phenoxy}propyl)-N,N-diethylamine (0.07 mmol) in pyridine (1 mL), copper powder was added (0.14 mmol), followed by potassium carbonate (0.35 mmol) and 1,1′-biphenyl-4-ol (0.14 mmol). The mixture was heated at 110° C. overnight, then diluted with H 2 O (2 mL) and extracted with EtOAc (3×2 mL). The combined organic extract was dried over sodium sulfate, filtered and concentrated to an oil, which was purified by column chromatography (Silica gel). The pure product was obtained from 1-6% MeOH/DCM (yield 11 mg).

MS m/z 518 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 7.83-7.79 (m, 3H), 7.59-7.57 (m, 4H), 7.45-7.43 (m, 4H), 7.42-7.34 (m, 4H), 7.11 (d, 2H), 7.05 (d, 3H), 4.10 (t, 2H), 2.80-2-60 (m, 6H), 2.00-2.10 (m, 2H), 1.30 (t, 3H), 1.10 (t, 3H) ppm.

›EXAMPLE 432

diethyl-[3-(4-{4-[4-(3-trifluoromethyl-phenoxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-amine

To a solution of N-(3-{4-[4-(4-bromophenyl)-1H-imidazol-1-yl]phenoxy}propyl)-N,N-diethylamine (0.07 mmol) in pyridine (1 mL), copper powder was added (0.14 mmol), followed by potassium carbonate (0.35 mmol) and 3-(trifluoromethyl)phenol (0.14 mmol). The mixture was heated at 110° C. overnight, then diluted with H 2 O (2 mL) and extracted with EtOAc (3×2 mL). The combined organic extract was dried over sodium sulfate, filtered and concentrated to an oil, which was purified by column chromatography (Silica gel). The pure product was obtained from 1-6% MeOH/DCM (yield 10 mg).

MS m/z 510 (M+H) + :

›EXAMPLE 433

[3-(4-{4-[4-(3,4-dichloro-phenoxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

To a solution of N-(3-{4-[4-(4-bromophenyl)-1H-imidazol-1-yl]phenoxy}propyl)-N,N-diethylamine (0.07 mmol) in pyridine (1 mL), copper powder was added (0.14 mmol) followed by potassium carbonate (0.35 mmol), and 3,4-dichlorophenol (0.14 mmol). The mixture was heated at 110° C. overnight, then diluted with H 2 O (2 mL) and extracted with EtOAc (3×2 mL). The combined organic extract was dried over sodium sulfate, filtered and concentrated to an oil, which was purified by column chromatography (Silica gel). The pure product was obtained from 1-6% MeOH/DCM (yield 15 mg).

MS m/z 510 (M+H) + :

›EXAMPLE 434

[3-(4-{2-butyl-1-[4-(4-methoxy-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and to this saturated aqueous sodium bicarbonate was added. The product-was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18, h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

4-Methoxyphenol (10 mmol) was dissolved in 15 ml of anhydrous DMF and potassium carbonate (30 mmol) was added with stirring at rt. 4-Fluoronitrobenzene (10 mmol) was added to this mixture, which was then heated under reflux at 80° C. for 18 h. The reaction was quenched with 30 ml of water and 30 ml of sodium bicarbonate, extracted with EtOAc (3×50 ml) and washed with sodium bicarbonate and water. The EtOAc layer was dried over anhydrous sodium sulfate and filtered, after which the solvent was removed in vacuuo.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (30 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(4-methoxyphenoxy)aniline, which was used directly for further transformation without further purification (yield 80%).

To a solution of 4-(4-methoxyphenoxy) aniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield 52%).

MS m/z 529 (M+H) + :

1 H NMR (CDCl 3 ): δ7.7 (d, 2H), 7.2 (d, 2H), 7.16 (s, 1H), 6.8-7.1 (m, 8H), 4.0 (t, 2H), 3.8 (s, 3H), 2.8-3.0 (m, 8H), 2.6 (m, 2H), 2.2 (m, 2H), 1.6(m, 2H), 1.2 (t, 6H), 0.8 (t, 3H) ppm.

›EXAMPLE 435

1-[2-(4-{2-butyl-1-[4-(3-fluoro-4-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-ethyl]-piperazine

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 5-15% EtOAc/Hexane (yield 80%). (MS: m/z 562 (M+H) + )

The above product was dissolved in MeOH (20 mL), and Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under hydrogen atmosphere using a balloon, according to General Procedure H. The Pd/C was removed by filtration. The solvent was removed in vacuuo, and the crude phenol (MS: m/z 472 (M+H) + ) was used for further transformation.

To a stirred solution of the phenol (0.16 mmol) obtained above in anhydrous DMF (5 mL) solid sodium hydride (60% dispersion in oil; 1.0 mmol) was added in portions. After the addition, 4-(2-methanesulfonyloxy)-piperazine-1-carboxylic acid tertbutylester (2.0 mmol) was added to the reaction mixture. The reaction mixture was heated at 90° C. overnight. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure product was obtained from 5-10% MeOH/DCM (yield˜45%).

This product was dissolved in DCM (10 mL) and HCl (4.0 M in dioxane, 1.0 mL) was added and stirrings continued overnight until reaction completed as indicated by HPLC. EtOAc (40 ml) added, followed by sodium bicarbonate (sat, 15 mL). The organic layer was washed with brine (10 mL) and dried with magnesium sulfate. The solvent was removed in in vacuuo to give the title compound as white solid (yield 37 mg).

MS m/z 584 (M+H) + :

1 H NMR (CDCl 3 ): δ7.70 (d, 2H), 7.20-7.35 (m, 5H), 7.14 (s, 1H), 7.08 (d, 2H), 6.92 (d, 2H), 4.05 (t, 2H), 3.0 (m, 4H), 2.8 (t, 2H), 3.4 (m, 6H), 1.6 (m, 2H), 1.3 (m, 3H), 0.9 (t, 3H) ppm.

›EXAMPLE 436

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-dimethyl-amine

To a stirred solution of 4-aminophenol (4.8 mmol) in MeOH (20 mL), 1-bromo-4′-(4-chlorophenethoxy)acetophenone (4 mmol) was added at rt. The resulting mixture was then heated to reflux for 45 min. The reaction mixture was then cooled to rt and the solvent was removed in vacuuo. The resulting solid was dissolved in EtOAc (30 mL), washed with H 2 O (2×20 mL) and brine (20 mL) and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired 1-(4-hydroxyphenyl)amino-4′-(4-chlorophenethoxy)acetophenone, which was used for further transformation.

The aminoacetophenone obtained as above (3 mmol) was dissolved in formic acid (3 mL) and added with ammonium formate (60 mmol). The resulting mixture was heated to 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product, 4-{4-[2-(4-chlorophenyl)ethoxy]phenyl}-1-[(4-hydroxy)phenyl]-1H-imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield˜50%).

To a solution of the product obtained above (0.5 mmol) in anhydrous THF (2 mL), NaH (60% dispersion in oil; 1 mmol) was added at 0° C. The resulting mixture was added with a solution of the mesylate of N,N-dimethylpropanol (0.6 mmol) in THF (1 mL). The reaction mixture was then heated to 70° C. overnight. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM.

MS m/z 476 (M+H) + :

1 H NMR (CDCl 3 ): δ7.76 (s, 1H), 7.73 (d, 2H), 7.38 (s, 1H), 7.31 (d, 2H), 7.25 (AB q, 4H), 6.99 (d, 2H), 6.92 (d, 2H,), 4.18 (t, 2H), 4.05 (t, 2H), 3.07 (t, 2H), 2.49 (t, 2H), 2.28 (s, 6H), 1.99 (q, 2H) ppm.

›EXAMPLE 437

4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-1-{4-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl}-1H-imidazole

To a solution of the product obtained above (0.5 mmol) in anhydrous THF (2 mL), NaH (60% dispersion in oil; 1 mmol) was added at 0° C. The resulting mixture was added with a solution of the mesylate of 2-(N-methylpyrrolidin-2-yl)ethanol (0.6 mmol) in THF (1 mL). The reaction mixture was then heated to 70° C. overnight. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was by obtained by elution with 4-6% MeOH/DCM (yield 125 mg)

MS m/z 503 (M+H) + :

1 H NMR (CDCl 3 ): δ7.75 (s, 1H), 7.72 (d, 2H), 7.38 (s, 1H), 7.31 (d, 2H), 7.26 (AB q, 4H), 6.95 (d, 2H), 6.92 (d, 2H), 4.17 (t, 2H), 3.04 (t, 2H), 2.90-2.50 (m, 4H), 2.43 (s, 3H), 2.30-1.50 (m, 7H) ppm.

›EXAMPLE 438

1-{2-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-ethyl}-piperazine

To a stirred solution of 4-aminophenol (4.8 mmol) in MeOH (20 mL), 1-bromo-4′-(4-chlorophenethoxy)acetophenone (4 mmol) was added at rt. The resulting mixture was then heated to reflux for 45 min. The reaction mixture was then cooled to rt and the solvent was removed in vacuuo. The resulting solid was dissolved in EtOAc (30 mL), washed with H 2 O(2×20 mL) and brine (20 mL) and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired 1-(4-hydroxyphenyl)amino-4′-(4-chlorophenethoxy)acetophenone, which was used for further transformation.

To a solution of the product obtained above (0.5 mmol) in anhydrous THF (2 mL), NaH (60% dispersion in oil; 1 mmol) was added at 0° C. The resulting mixture was added with a solution of the mesylate of 1-(t-butyloxycarbonyl)-2-(2-hydroxy)ethylpiperazine (0.6 mmol) in THF (1 mL). The reaction mixture was then heated to 70° C. overnight. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 4-6% MeOH/DCM (yield˜50%).

The product obtained above was treated with 4M HCl in dioxane (1 mL) and the resulting mixture was stirred at rt for 4 h. Evaporation of the solvent, repeated washing of the hydrochloride salt thus obtained with diethyl ether and subsequent drying in vacuuo afforded the desired product.

MS m/z 503 (M+H) + :

1 H NMR (CD 3 OD): δ9.47 (s, 1H), 8.28(s, 1H), 7.76 (d, 2H), 7.72 (d, 2H), 7.33 (d, 2H), 7.29 (s, 4H), 7.06 (d, 2H), 4.58 (broad t, 2H), 4.22 (t, 2H), 3.83 (broad t, 4H), 3.74 (broad t, 6H), 3.06 (t, 2H) ppm.

›EXAMPLE 439

[3-(4-{2-(3-cyclohexyl-propyl)-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (4 mmol) in MeOH (10 mL) at rt, pyrrolidone hydrotribromide (4.8 mmol) was added, according to General Procedure R1. The reaction mixture was stirred at rt for 1 h (monitored by LC-MS). The solvent was then removed in vacuuo and the crude 2-bromo-1-≡4-[3-(diethylamino)propoxy]phenyl}ethanone was directly used for further transformation.

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of 4-cyclohexylbutanoyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 652 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 0.75-1.65 (m, 15H), 1.07 (t, 6H), 1.97 (m, 2H), 2.62 (q, 4H), 2.63-2.70 (m, 4H), 4.02 (t, 2H), 6.90 (d, 2H), 7.07 (d, 2H), 7.14 (s, 1H), 7.22 (br s, 1H), 7.23 (br d, 1H), 7.25 (d, 1H), 7.31 (d, 2H), 7.69 (d, 2H) ppm.

›EXAMPLE 440

diethyl-(3-{4-[1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-2-(3-phenoxy-propyl)-1H-imidazol-4-yl]-phenoxy}-propyl)-amine

To a stirred solution of the alkylated aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (1.2 mmol, 6 eq) was added, followed by a slow addition of 4-phenoxybutanoyl chloride (0.6 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

MS m/z 662 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ1.06 (t, 6H), 1.97 (m, 2H), 2.24 (m, 2H), 2.60 (q, 4H), 2.67 (t, 2H), 2.88 (t, 2H), 3.99 (t, 2H), 4.03 (t, 2H), 6.80 (d, 2H), 6.90-7.25 (m, 8H), 7.01 (d, 2H), 7.15 (s, 1H), 7.28 (d, 1H), 7.70 (d, 2H) ppm.

›EXAMPLE 441

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-methyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of acetyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 519 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.67 (d, 2H), 7.22 (d, 2H), 7.21 (m, 5H), 6.96 (d, 2H), 6.84 (d, 2H), 4.17 (t, 2H), 4.07 (t, 2H), 3.06 (t, 2H), 2.78 (t, 2H), 2.74 (m, 4H), 2.36 (s, 3H), 2.06 (m, 2H), 1.13 (t, 6H) ppm

›EXAMPLE 442

3-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-1-ethyl-piperidine

To a stirred solution of 4-benzyloxyacetophenone (7.0 mmol) in anhydrous DCM (30.0 mL) and MeOH (5.0 mL) at rt, pyridinium bromide perbromide (1.1 eq.) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate. The solvent was then removed in vacuuo to give a white solid. The 1-[4-(benzyloxy)phenyl]-2-bromoethanone was used for further transformation without further purification.

To a stirred solution of 4-(4-fluoro-3-trifluoromethyl-phenoxy)-aniline (1.64 mmol) in anhydrous DMF (30 mL) DIEA (3 eq) was added, followed by slow addition of the 1-[4-(benzyloxy)phenyl]-2-bromoethanone described above (2 eq), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC and HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired alkylated aniline, which was purified by chromatography (Silica gel). Pure product was obtained by elution with 5-20% EtOAc/Hexane (yield˜50-60%).

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 5-15% EtOAc/Hexane (yield 80%).

A stirred solution of the 4-(1-{4-[4-fluoro-3-(trifluoromethyl)phenoxy]phenyl}-2-butyl-1H-imidazol-4-yl)phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of 1-(methylamino)piperidin-3-ol was then added to the reaction mixture, which was heated at 90° C. overnight, according to General Procedure T3. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained by elution with chromatography in 5-10% MeOH/DCM (yield 52.0 mg)

MS m/z 583 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.7 (m, 2H), 7.3 (m, 3H), 7.24 (m, 2H), 7.13 (s, 1H), 7.07 (d, 2H, J 8.8 Hz), 6.94 (m, 2H), 0.9-4.4 (m, 23H) ppm.

›EXAMPLE 443

diethyl-[3-(4-{1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-2-methyl-1H-imidazol-4-yl}-phenoxy)-propyl]-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium 4-fluoro-3-trifluoromethyl-phenoxide (2.2 mmol) in THF (may be generated by adding the corresponding alcohol to a 1M solution of potassium t-butoxide in THF) was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the reaction mixture was treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene. The crude product could be used directly for further transformation.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-[4-fluoro-3-(trifluoromethyl)phenoxy]aniline, which was used directly for further transformation without further purification.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (8.0 mmol) was added. The mesylate of N,N-diethyaminopropanol (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone. The crude alkylated product was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM. (yield 50-60%)

To a stirred solution of the 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (1 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 1.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo, the residue was treated with saturated sodium bicarbonate and the product was isolated in EtOAc. The combined organic layers were washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 3.0 mmol) was added, followed by slow addition of acetyl chloride (2 eq., 2.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was purified using silica gel chromatography. Pure product was obtained by elution with 3-4% MeOH/DCM (Yield 40-45%).

To a stirred solution of the amide described above (0.5 mmol) in acetic acid (1 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 4-6% MeOH/DCM (yield: 108 mg).

MS m/z 542 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.33 (m, 5H), 7.18 (s, 1H), 7.09 (d, 2H), 6.91 (d, 2H) 4.03 (t, 2H), 2.63 (m, 6H), 2.41 (s, 3H), 2.01 (m, 2H), 1.08 (t, 6H) ppm

›EXAMPLE 444

(3-{4-[4-(4-benzyloxy-phenyl)-2-butyl-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

The N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(N,N-diethylaminopropoxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of the 4′-benzyloxyacetophenone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 2.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (20 mL) and the product was isolated in EtOAc (2×20 mL). The combined organic layers were washed with saturated sodium thiosulfate (2×10 mL), water (2×10 mL) and brine (15 mL). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alpha-bromoacetophenone was purified by chromatography (Silica gel). Pure product was obtained by elution with 20-30% EtOAc/hexane (yield˜70-75%)

To a stirred solution of the 4-(N,N-diethylaminopropoxy)aniline (1.2 eq., 2 mmol) in anhydrous DMF (5 mL) the alpha-bromoacetophenone (1.6 mmol) described above was added slowly, according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated aniline described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of valeryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 512 (M+H) + :

1 H NMR (CDCl 3 ): δ7.69 (d, 2H), 7.15-7.50 (m, 8H), 7.09 (s, 1H), 6.96 (m, 3H), 5.05 (s, 2H), 4.12 (t, 2H), 3.21 (broad m, 2H), 3.15 (q, 4H), 2.64 (t, 2H) 2.38 (broad m, 2H), 1.60 (q, 2H) 1.41 (t, 6H) 1.20-1.35 (m, 2H), 0.81 (t, 6H) ppm.

›EXAMPLE 445

[3-(4-{2-butyl-1-[4-(2,5-difluoro-benzyloxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the product 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (6 mL) at 0° C., a 1M solution of a potassium alkoxide (2.2 mmol) in THF (may be generated by adding the 2,5-difluorobenzyl alcohol to a 1M solution of KOBu t in THF) was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product could be used directly for further transformation without any purification, or after purifying using silica gel column chromatography.

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (6 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford 4-(2,5-difluoro-benzyloxy)aniline, which was used directly for further transformation without further purification (yield 80%).

To a solution of 4-(2,5-difluoro-benzyloxy)aniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product by elution with 2-4% MeOH/DCM (yield 50%).

To a stirred solution of the amide described above (1 mmol) in acetic acid (4 mL), ammonium acetate (20 mmol, 20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 4-6% MeOH/DCM (yield 208 mg).

MS m/z 549 (M+H) + :

1 H NMR (CDCl 3 ): δ7.68 (d, 2H), 7.24 (m, 5H), 7.13 (s, 1H), 7.06 (d, 2H), 6.89 (d, 2H), 5.17 (s, 2H), 4.02 (t, 2H), 2.62-2.78 (m, 8H), 1.98 (m, 2H), 1.60 (m, 2H), 1.27 (m, 2H), 1.11 (t, 6H), 0.82 (t, 3H) ppm.

›EXAMPLE 446

3-(S)-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxymethyl)-1-ethyl-piperidine

To a stirred solution of 4-benzyloxyacetophenone (7.0 mmol) in anhydrous DCM (30.0 mL) and MeOH (5.0 mL) at rt, pyridinium bromide perbromide (1.1 eq.) was added. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium. sulfate. The solvent was then removed in vacuuo to give a white solid. The alpha-bromoacetophenone was used for further transformation without further purification.

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 5-15% EtOAc/Hexane (yield 80%). (MS: m/z 562 (M+H) + )

A stirred solution of the 4-(1-{4-[4-fluoro-3-(trifluoromethyl)phenoxy]phenyl}-2-butyl-1H-imidazol-4-yl)phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of [(3S)-1-ethylpiperidin-3-yl]methanol (1.5-2.0 eq) was added to the reaction mixture, which was heated at 90° C. overnight, according to General Procedure T3. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate.

The solvent was removed in vacuuo. Pure imidazole was obtained by elution with chromatography in 5-10% MeOH/DCM (yield 50.0 mg).

MS m/z 597 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.70 (d, 2H), 7.20-7.35 (m, 5H), 7.14 (s, 1H), 7.08 (d, 2H), 6.92 (d, 2H), 4.05 (m, 1H), 3.92 (m, 2H), 2.60 (m, 4H), 1.0-2.5 (m, 18H) ppm.

›EXAMPLE 447

(3-{4-[4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-(2,4,4-trimethyl-pentyl)-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 3,5,5-trimethyl hexanoyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z value (M+H) + ; 617

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.22 (d, 2H), 7.21 (m, 5H), 6.96 (d, 2H), 6.88 (d, 2H), 4.18 (t, 2H), 4.07 (t, 2H), 3.09 (t, 2H), 2.88 (d, 2H), 2.79 (m, 6H), 2.05 (m, 3H), 1.11 (t, 6H), 0.97 (d, 2H), 0.87 (d, 3H), 0.78 (s, 9H) ppm

›EXAMPLE 448

3-(R)-(4-{2-butyl-1-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxymethyl)-1-ethyl-piperidine

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous THF (20 mL) at 0° C., TEA (3 eq, 3 mmol) was added, followed by slow addition of valeryl chloride (3 eq, 3.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by TLC and HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (1.0 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 5-15% EtOAc/Hexane (yield 80%). (MS: m/z 562 (M+H) + )

A stirred solution of the 4-(1-{4-[4-fluoro-3-(trifluoromethyl)phenoxy]phenyl}-2-butyl-1H-imidazol-4-yl)phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of [(3R)-1-ethylpiperidin-3-yl]methanol (1.5-2.0 eq) was added to the reaction mixture, which was heated at 90° C. overnight, according to General Procedure T3. After cooling the mix to rt, Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained by elution with chromatography in 5-10% MeOH/DCM (yield 50.0 mg).

MS m/z 597 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.70 (d, 2H), 7.20-7.35 (m, 5H), 7.14 (s, 1H), 7.08 (d, 2H,), 6.92 (d, 2H), 4.05 (m, 1H), 3.92 (m, 2H), 2.60 (m, 4H), 1.0-2.5 (m, 18H), ppm.

›EXAMPLE 449

[3-(4-{2-butyl-1-[4-(3-tert-butyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the product 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (30 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(3-tert-butyl-phenoxy)aniline, which was used directly for further transformation without further purification (yield 80%).

To a solution of 4-(3-tert-butyl-phenoxy)aniline (1 eq, 2 mmol) in anhydrous DMF (6 mL), DIEA (3 eq 6 mmol) was added, followed by addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product by elution with 2-4% MeOH/DCM (yield 51%).

MS m/z 555 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 7.7 (d, 2H), 7.3 (m, 4H), 7.1-7.2 (m, 5H), 6.9 (d, 2H), 4.0 (t, 2H), 2.8-3.0 (m, 8H), 2.0 (m, 2H), 1.6 (m, 2H), 1.4(m, 2H), 1.2 (15H), 0.8 (t, 3H) ppm

›EXAMPLE 450

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-methoxymethyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of methoxy acetyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 549 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.72 (d, 2H), 7.37 (d, 2H), 7.48 (m, 5H), 6.98 (d, 2H), 6.85 (d, 2H), 4.41 (s, 2H), 4.18 (t, 2H), 4.07 (t, 2H), 3.45 (s, 3H), 3.06 (t, 2H), 2.86 (m, 6H), 2.08 (m, 2H), 1.17 (t, 6H) ppm

›EXAMPLE 451

(3-{4-[4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-(1-ethyl-propyl)-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 2-ethyl butyryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 575 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.71 (d, 2H), 7.27 (m, 6H), 7.06 (s, 1H), 6.95 (d, 2H), 6.87 (d, 2H), 4.09 (t, 2H), 4.02 (t, 2H), 3.07 (t, 2H), 2.72 (m, 6H), 2.49 (m, 1H), 2.06 (m, 2H), 1.82 (m, 2H), 1.68 (m, 2H), 1.08 (t, 6H), 0.96 (t, 3H), 0.88 (t, 3H) ppm

›EXAMPLE 452

(3-{4-[4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-(3-phenoxy-propyl)-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 4-phenoxy butyryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 638 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.23-7.25 (m, 8H), 7.12 (s, 1H), 6.92 (m 5H), 6.81 (d, 2H), 4.18 (t, 2H), 4.09 (t, 2H), 3.95 (t, 2H), 3.07 (t, 2H), 2.85 (m, 8H), 2.22 (m, 2H), 2.05 (m, 2H), 1.20 (t, 6H) ppm

›EXAMPLE 453

(3-{4-[4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-(1-propyl-butyl)-imidazol-1-yl]-phenoxy}-propyl)-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 2-N-propyl-N-valeryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 602 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.23-7.25 (m, 6H), 7.04 (s, 1H), 6.97 (d, 2H), 6.87 (d, 2H), 4.18 (t, 2H), 4.09 (t, 2H), 3.06 (t, 2H), 2.87 (m, 6H), 2.63 (m, 1H), 2.13 (m, 2H), 1.81 (m, 2H), 1.54 (m, 2H), 1.17 (t, 10H), 0.89 (t, 6H) ppm

›EXAMPLE 454

{3-[4-(2-(4-chloro-phenoxymethyl)-4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General. Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of 4-chlorophenoxy acetyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 644 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.72 (d, 2H), 7.36 (d, 2H), 7.23-7.25 (m, 4H), 7.23 (m, 4H), 6.91 (m, 5H), 4.95 (s, 2H), 4.17 (t, 2H), 4.05 (t, 2H), 3.07 (m, 8H), 2.21 (m, 2H), 1.27 (t, 6H) ppm

›EXAMPLE 455

{3-[4-(2-benzyloxymethyl-4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of benzyloxyacetyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 624 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.71 (d, 2H), 7.68 (d, 2H), 7.31 (m, 7H), 7.25 (d, 2H), 7.21 (s, 1H), 6.94 (d, 2H), 6.89 (d, 2H), 4.58 (s, 2H), 4.49 (s, 2H), 4.15 (t, 2H), 4.08 (t, 2H), 3.11 (t, 2H), 2.89 (m, 6H), 2.18 (m, 2H), 1.35 (t, 6H) ppm

›EXAMPLE 456

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-isobutyl-5-methyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]phenyl}-propan-1-one (1.0 mmol) in dioxane (10.0 mL) at rt, pyridinium bromide perbromide (1.1 eq) was added. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate, The solvent was then removed in vacuuo to give a white solid. The alpha-bromoketone was used for further transformation without further purification.

A solution of the above alpha-bromoketone (1.0 eq), N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.0 eq), and DIEA (1.5 eq) in anhydrous DMF (10 mL) was stirred under nitrogen at rt until completion, as indicated by HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. The solvent was removed in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained by elution with 2-7% MeOH/DCM (yield˜55%).

To a stirred solution of alkylated aniline described above (0.55 mmol) in anhydrous THF (5 mL) at 0° C., TEA (3.0 mmol) was added, followed by slow addition of isovaleryl chloride (5.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.55 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole (yield 190 mg)

MS m/z 574 (M+H) + :

›EXAMPLE 457

{3-[4-(4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-isobutyl-5-propyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]phenyl}-pentan-1-one (1.0 mmol) in dioxane (10.0 mL) at rt, pyridinium bromide perbromide (1.1 eq.) was added. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate. The solvent was then removed in vacuuo to give a white solid. The alpha-bromophenone was used for further transformation.

A solution of the above alpha-bromophenone (1.0 eq), N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.0 eq), and DIEA (1.5 eq) in anhydrous DMF (10 mL) was stirred under nitrogen at rt until completion, as indicated by HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. The solvent was removed in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained by elution with 2-5% MeOH/DCM (yield˜50%).

To a stirred solution of alkylated aniline described above (0.48 mmol) in anhydrous THF (5 mL) at 0° C., DMAP (0.25 eq) was added, followed by slow addition of isovaleryl chloride (5.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.48 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole (yield 180 mg).

MS m/z 602 (M+H) + :

1 H NMR (CDCl 3 ): δ7.58 (d, 2H), 7.28 (d, 2H), 7.21 (d, 2H), 7.11 (d, 2H), 6.98 (d, 2H), 6.91 (d, 2H), 4.17 (t, 2H), 4.08 (t, 2H), 3.07 (t, 2H), 2.6 (t, 2H), 2.57 (q, 6H), 2.47 (t, 4H), 2.36 (d, 2H), 2.0 (m, 3H), 1.3 (m, 2H), 1.05 (t, 6H), 0.82 (d, 6H), 0.72 (t, 3, H) ppm.

›EXAMPLE 458

{3-[4-(5-butyl-4-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-isobutyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]phenyl}-hexan-1-one (0.785 mmol) in dioxane (10.0 mL) at rt, pyridinium bromide perbromide (1.1 eq) was added. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC. The mixture was diluted with EtOAc (100 ml) and washed with H 2 O (2×50 ml), brine (30 ml) and dried with magnesium sulfate. The solvent was then removed in vacuuo to give a white solid. The alpha-bromophenone was used for further transformation.

A solution of the above alpha-bromophenone (1.0 eq), N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.0 eq), and DIEA (1.5 eq) in anhydrous DMF (10 mL) was stirred under nitrogen at rt for 24 hour. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained by elution with 2-7% MeOH/DCM (yield˜47%).

To a stirred solution of alkylated aniline described above (0.31 mmol) in anhydrous THF (5 mL) at 0° C., DMAP (0.25 eq) was added, followed by slow addition of isovaleryl chloride (5.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.31 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole (yield 108 mg).

MS m/z 616 (M+H) + :

1 H NMR (CDCl 3 ): δ7.6 (d, 2H), 7.28 (d, 2H), 7.21 (d, 2H), 7.11 (d, 2H), 7.00 (d, 2H), 6.90 (d, 2H), 4.18 (t, 2H), 4.08 (t, 2H, 3.06 (t, 2H), 2.45-2.65 (m, 8H), 2.36 (d, 2H), 2.0 (m, 4H), 0.7-1.3 (m, 18H) ppm.

›EXAMPLE 459

{4-{4-{2-(4-chloro-phenyl)-ethoxy]-phenyl}-1-[4-(3-diethylamino-propoxy)-phenyl]-1H-imidazol-2-yl}-MeOH

To a stirred solution of 4-fluoronitrobenzene (2.0 mmol) in anhydrous THF (5 mL) at 0° C., a 1M solution of a potassium diethylaminopropoxide (2.2 mmol) in THF was added dropwise and under a nitrogen stream, according to General Procedure L1. The reaction mixture was stirred at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then treated with cold H 2 O (15 mL), and extracted with EtOAc (2×15 mL). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired 4-alkoxynitrobenzene. The crude product was used directly for further transformation.

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (5 mL) at rt, solid potassium carbonate (9.0 mmol) was added. 4-chlorophenethyl mesylate (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched using cold water (20 ml) and the product was isolated in EtOAc (2×20 ml). The combined organic layers were washed with saturated sodium bicarbonate (2×10 ml), water (2×10 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[2-(4-chlorophenyl)ethoxy]phenyl}ethanone. The crude alkylated acetophenone was used for further transformation.

To a stirred solution of 1-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-2-[4-(3-diethylamino-propoxy)-phenylamino]-ethanone described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of benzyloxyacetyl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the pure imidazole (0.48 mmol) described above 6N HCl was added and the reaction mixture was refluxed overnight. The reaction mixture was then cooled to rt and neutralized with 3N sodium hydroxide solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained by elution with 4-6% MeOH/DCM (yield: 130 mg).

MS m/z 534 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.66 (d, 2H), 7.41 (d, 2H), 7.28 (d, 2H), 7.22 (m, 3H), 6.99 (d, 2H), 6.89 (d, 2H), 4.62 (s, 2H), 4.17 (t, 2H), 4.08 (t, 2H), 3.07 (t, 2H), 2.88 (m, 6H), 2.18 (m, 2H), 1.24 (t, 6H) ppm

›EXAMPLE 460

diethyl-[3-(4-{2-isobutyl-4-[4-(4-phenoxy-benzyloxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-amine

To a stirred solution of N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.0 eq., 2.5 mmol) in anhydrous DMF (20 mL) DIEA (3 eq) was added, followed by slow addition of the 1-[4-(benzyloxy)phenyl]-2-bromoethanone (2.5 mmol). The reaction mixture was stirred under nitrogen at rt until completion, as indicated by HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained by elution with 2-7% MeOH/DCM (yield˜30%).

To a stirred solution of the alkylated aniline described above (0.88 mmol) in anhydrous DCM (10 mL) at 0° C., TEA (3.0 mmol) was added, followed by slow addition of isovaleryl chloride (5.0 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.88 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the cyclized product, (crude ˜80%) which was taken to the next transformation without purification.

The above product was dissolved in MeOH (20 mL), Pd/C (100 mg) was added and the heterogeneous mixture was stirred overnight under H 2 atmosphere using a balloon, according to General Procedure T2. The Pd/C was removed by filtration. The solvent was removed in vacuuo, and the crude 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol was used for further transformation without purification.

A stirred solution of the 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) obtained above in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 10 mmol) in portions. The mesylate of (4-phenoxyphenyl)methanol (1.1 eq) was added to the reaction mixture, which was stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained by elution with chromatography in 5-10% MeOH/DCM (yield 70.0 mg).

MS m/z 604 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.70 (d, 2H) 6.9-7.4 (m, 16H), 5.0 (s, 2H), 4.1 (t, 2H), 3.0 (m, 6H), 2.52 (d), 2.26 (m, 2H), 2.01 (m, 1H), 1.31 (t, 6H), 0.84 (d, 6H) ppm.

›EXAMPLE 461

[3-(4-{4-[4-(4-benzyloxy-benzyloxy)-phenyl]-2-isobutyl-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

A stirred solution of 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of [4-(benzyloxy)phenyl]methanol (1.1 eq) was added to the reaction mixture, and stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography with 5-10% MeOH/DCM (yield 70.0 mg)

MS m/z 618 (M+H) + :

1 H NMR (CDCl 3 ): δ7.70 (d, 2H), 7.3-7.45 (m, 7H), 7.21 (d, 2H), 7.1 (s, 1H), 6.9 (m, 6H), 5.07 (s, 2H), 5.00 (s, 2H), 4.1 (t, 2H), 3.0 (m, 6H), 2.52 (d, 2H), 2.26 (m, 2H), 2.01 (m, 1H), 1.31 (t, 6H), 0.84 (d, 6H) ppm.

›EXAMPLE 462

[3-(4-{4-[4-(2-benzenesulfonylmethyl-benzyloxy)-phenyl]-2-isobutyl-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (1.0 eq., 2.5 mmol) in anhydrous DMF (20 mL) DIEA (3 eq) was added, followed by slow addition of 1-[4-(benzyloxy)phenyl]-2-bromoethanone (2.5 mmol). The reaction mixture was stirred under nitrogen at rt until completion, as indicated by HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in Et 2 O. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained by elution with 2-7% MeOH/DCM (yield˜30%).

A stirred solution of 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of {2-[(phenylsulfonyl)methyl]phenyl}methanol (1.1 eq) was added to the reaction mixture, and stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography with 5-10% MeOH/DCM (yield 77 mg).

MS m/z 666 (M+H) + :

1 H NMR (CDCl 3 ): δ7.6-7.73 (m, 6), 7.3-7.5 (m, 4H), 7.20 (d, 2H), 7.1 (m, 2H), 6.97 (d, 2H), 6.9 (d, 2H), 4.93 (s, 2H), 4.5 (s, 2H), 4.07 (t, 2H), 2.6 (t, 2H), 2.63 (q, 4H), 2.53 (d, 2H), 2.01 (m, 3H), 1.08 (t, 6H), 0.85 (d, 6H) ppm.

›EXAMPLE 463

diethyl-[3-(4-{2-isobutyl-4-[4-(3,4,5-trimethoxy-benzyloxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-amine

A stirred solution of 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of (3,4,5-trimethoxyphenyl)methanol (1.1 eq) was added to the reaction mixture, and stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography with 5-10% MeOH/DCM (yield 66 mg).

MS m/z 602 (M+H) + :

1 H NMR (CDCl 3 ): δ7.71 (d, 2H), 7.21 (d, 2H), 6.97 (m, 4H), 6.66 (s, 1H), 5 (s, 2H), 4.1 (t, 2H), 3.86 (s, 6H), 3.82 (s, 3H), 3.0 (m, 6H), 2.51 (d, 2H), 2.25 (m, 2H), 2.01 (m, 1H), 1.3 (t, 6H), 0.84 (d, 6H) ppm.

›EXAMPLE 464

[3-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 4′-hydroxyacetophenone (91 mmol) in DMF (80 mL) at rt, solid potassium carbonate (153 mmol) was added. The mesylate prepared from 3-diethylamino-1-propanol and methanesulfonyl chloride (76 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was quenched by treating the mixture with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (100 mL) and washed with H 2 O (2×50 mL) and brine (50 mL). The organic layer was dried over sodium sulfate, and the solvent was removed in vacuuo to afford the desired 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone. The crude alkylated product was used for further transformation after purifying using silica gel column chromatography (1-4% MeOH/DCM).

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (5.2 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 6.2 mmol) was added slowly in small portions, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of 4-amino-4′-chlorodiphenyl ether (1.2 eq., 6.2 mmol) in anhydrous DMF (10 mL) DIEA (3 eq. 16 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (5.2 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was extracted in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield˜22%).

To a stirred solution of alkylated 4-amino-4′-chlorodiphenyl ether described above (0.4 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 1.2 mmol) was added, followed by slow addition of isovaleryl chloride (3 eq., 1.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

The combined organic layers was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 117 mg).

MS m/z 532 (M+H) + :

1 H NMR (CDCl 3 ): δ7.63 (d, 2H), 7.28 (d, 2H), 7.21 (d, 2H), 7.06 (s, 1H), 7.01 (d, 2H), 6.98 (d, 2H), 6.83 (d, 2H), 3.99 (t, 2H), 2.79 (t, 2H), 2.72 (q, 4H), 2.49 (d, 2H), 2.30-1.90 (m, 3H), 1.10 (t, 6H), 0.80 (d, 6H) ppm.

›EXAMPLE 465

[3-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-(2-cyclopentyl-ethyl)-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (5.2 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 6.2) was added slowly in small portions, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of alkylated 4-amino-4′-chlorodiphenyl ether described above (0.4 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 1.2 mmol) was added, followed by slow addition of 3-cyclopentylpropionyl chloride (3 eq., 1.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone (0.4 mmol) obtained as above in acetic acid (3 mL), solid ammonium acetate (8 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×15 mL). The combined organic layers was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 180 mg).

MS m/z 572 (M+H) + :

1 H NMR (CDCl 3 ): δ7.69 (d, 2H), 7.35 (d, 2H), 7.29 (d, 2H), 7.14 (s, 1H), 7.08 (d, 2H), 7.02 (d, 2H), 6.89 (d, 2H), 4.05 (t, 2H), 2.95 (t, 2H) 2.85 (q, 4H), 2.71-2.65 (m, 2H), 2.19-2.12 (m, 3H), 1.72-1.61 (m, 4H), 1.59-1.42 (m, 4H), 1.21 (t, 6H), 1.01 (m, 2H) ppm.

›EXAMPLE 466

[3-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-phenethyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the alkylated 4-chloroalkoxy aniline described above (0.4 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 1.2 mmol) was added, followed by slow addition of hydrocinnamoyl chloride (3 eq., 1.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone (˜0.4 mmol) obtained as above in acetic acid (3 mL), solid ammonium acetate (8 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×15 mL). The combined organic layers was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-4% MeOH/DCM) (yield 50 mg).

MS m/z 580 (M+H) + :

1 H NMR (CDCl 3 ): δ8.41 (m, 2H), 7.92 (m, 2H), 7.62 (d, 2H, 7.33 (d, 2H), 7.25-7.21 (m, 2H), 7.13-7.08 (m, 1H), 7.04 (s, 1H), 6.98 (m, 2H), 6.92 (m, 2H), 6.75 (m, 2H), 4.05 (t, 2H), 3.31 (m, 2H), 3.26-3.05 (m, 6H), 2.35 (m, 2H), 1.40 (t, 6H), 1.21 (m, 2H) ppm.

›EXAMPLE 467

[3-(4-{2-(4-tert-butyl-phenoxymethyl)-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

3-Diethylaminopropanol (20 mmol, 1 eq) was dissolved in DCM (25 mL), TEA (40 mmol, 2 eq) was added and the mixture was cooled to 0° C. To this mixture, methanesulfonyl chloride (30 mmol, 1.5 eq) was added slowly with stirring and the reaction mixture was stirred at 0° C. for an hour and at rt for another hour (until the reaction was complete by HPLC). The solvent was removed and to this saturated aqueous sodium bicarbonate was added. The product was extracted with EtOAc (3×) and washed with sodium bicarbonate and water. The solvent was removed in vacuuo.

The mesylate from the previous step (20 mmol, 1 eq) was dissolved in anhydrous DMF (25 mL) to which 4-hydroxyacetophenone (20 mmol, 1 eq) and potassium carbonate (60 mmol, 3 eq) were added. The mixture was heated under reflux at 85° C. for 18 h (until the reaction was complete by HPLC), after which it was cooled to rt. Saturated aqueous sodium bicarbonate was added to the mixture, which was then transferred to a separatory funnel. The product was extracted with EtOAc and washed with sodium bicarbonate and water. The solvent was removed in vacuuo and the product 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was purified by flash chromatography (going by increasing gradient up to 10% MeOH in DCM). The overall yield was 60%.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (5 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a solution of 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone described above (2 mmol) in anhydrous DCM (5 mL), PS-carbodimide (2 eq, 4 mmol) and 4-t-butylphenoxy-acetic acid (3 mmol) were added. The reaction mixture was shaken overnight and next day filtered to give the desired amide. The crude amide was used for further transformation.

To a stirred solution of the amide described above (2 mmol) in acetic acid (8 mL), ammonium acetate (20 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield 255 mg)

MS m/z 638 (M+H) + :

1 H NMR (CDCl 3 ): δ7.72 (d, 2H), 7.44 (d, 2H), 7.28-7.35 (m, 5H), 6.8-7.1 (m, 8H), 5.01 (s, 2H), 4.06 (t, 2H), 3.13-3.24 (m, 6H), 2.28 (m, 2H), 1.23-1.38 (m, 15H) ppm.

›EXAMPLE 468

[3-(4-{2-butyl-1-[4-(2,4-dichloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 2,4-dichlorophenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 ml), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 ml) and brine (50 ml), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(2,4-dichloro-phenoxy)-1-nitrobenzene. The crude product was used for further transformation.

The nitro intermediate (10 mmol) obtained above was dissolved in MeOH (20 mL), and treated with SnCl 2 .2H 2 O (50 mmol), according to General Procedure I. The reaction mixture was heated under reflux until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo and the residue was treated with 4.0 N aqueous NaOH to pH˜8. The residue was extracted with EtOAc (2×50 mL), washed with 1.0 N aqueous NaOH (50 mL), brine (50 mL) and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(2,4-dichloro-phenoxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (4.4 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 5.3 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of 4-(2,4-dichloro-phenoxy)aniline described above (1.2 eq., 5.2 mmol) in anhydrous DMF (20 mL) DIEA (3 eq. 15 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (4.4 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product obtained from 2-4% MeOH/DCM (yield˜5%).

To a stirred solution of alkylated 4-(2,4-dichloro-phenoxy)aniline described above (0.2 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 0.6 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 0.6 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the N-alkylated anilide (0.2 mmol) obtained as above in acetic acid (3 mL), solid ammonium acetate (6 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×15 mL). The combined organic layers was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM).

MS m/z 566 (M+H) + :

1 H NMR (CDCl 3 ): δ7.96 (s, 1H), 7.87 (m, 2H), 7.64 (d, 2H), 7.42 (m, 2H), 7.30 (d, 2H), 7.15 (s, 1H), 6.94-6.84 (m, 2H), 4.12 (m, 2H), 3.71-3.42 (m, 6H), 3.14 (m, 2H), 2.29 (t, 2H), 1.59-1.50 (m, 2H), 1.41-1.32 (m, 2H), 1.31 (t, 6H), 0.85 (m, 3H) ppm.

›EXAMPLE 469

[3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-5-methyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the 1-[4-(3-diethylamino-propoxy)-phenyl]-propane-1-one (1.08 mmol) in anhydrous MeOH (15 mL), pyrrolidone hydrotribromide (1.6 eq.) was added, according to General Procedure R1. The reaction mixture was heated under reflux overnight. The solvent was then removed in vacuuo and the crude alpha-bromophenone was used for further transformation.

To a stirred solution of the above alpha-bromoketone (1.0 eq), 4-(4-chloro-phenoxy)-aniline (1.0 eq) in anhydrous DMF (10 mL) DIEA (1.0 eq) was added. The reaction mixture was stirred under nitrogen at 90° C. until completion, as indicated by HPLC. The reaction mixture was cooled to rt then diluted with Et 2 O (100 mL) and washed with sodium bicarbonate (10%, 30 ml), H 2 O (2×30 mL), brine (30 mL) and dried with magnesium sulfate. Evaporation of solvent in vacuuo gave a crude oil. The crude alkylated aniline was purified by chromatography (Silica gel). Pure product was obtained from 2-7% MeOH/DCM (yield˜20%).

To a stirred solution of alkylated aniline described above (0.2 mmol) in anhydrous THF (10 mL) at 0° C., DMAP (0.3 eq.) was added, followed by slow addition of valeryl chloride (5.0 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to ambient temperature until completion, as indicated by HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.2 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield 66 mg).

MS m/z 546 (M+H) + :

1 H NMR (CDCl 3 ): δ7.59 (d, 2H), 7.35 (d, 2H), 7.19 (d, 2H), 7.08 (d, 2H), 7.03 (d, 2H), 6.93 (d, 2H), 4.02 (t, 2H), 2.51-2.64 (m, 8H), 2.13 (s, 3H), 1.94 (m, 2H), 1.58 (m, 2H), 1.27 (m, 2H), 1.04 (t, 6H), 0.82 (t, 3H) ppm.

›EXAMPLE 470

[3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-5-propyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the 1-[4-(3-diethylamino-propoxy)-phenyl]-pentane-1-one (1.08 mmol) in anhydrous MeOH (15 mL), pyrrolidone hydrotribromide (1.6 eq.) was added, according to General Procedure R1. The reaction mixture was heated under reflux overnight. The solvent was then removed in vacuuo and the crude alpha-bromophenone was used for further transformation.

MS m/z 574 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.50 (d, 2H), 7.34 (d, 2H), 7.20 (d, 2H), 7.07 (d, 2H), 7.02 (d, 2H), 6.87 (d, 2H), 4.07 (t, 2H), 3.1-3.2 (m, 6H), 2.40-2.6 (m, 4H), 2.2 (m, 2H), 1.2-1.4 (m, 12H), 0.79 (t, 3H), 0.72 (t, 3H) ppm.

›EXAMPLE 471

[3-(4-{2,5-dibutyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the 1-[4-(3-diethylamino-propoxy)-phenyl]-hexanane-1-one (1.08 mmol) in anhydrous MeOH (15 mL), pyrrolidone hydrotribromide (1.6 eq.) was added, according to General Procedure R1. The reaction mixture was heated under reflux overnight. The solvent was then removed in vacuuo and the crude alpha-bromophenone was used for further transformation.

MS m/z 588 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.54 (d, 2H), 7.36 (d, 2H), 7.24 (d, 2H), 7.09 (d, 2H), 7.03 (d, 2H), 6.90 (d, 2H), 4.07 (t, 2H), 3.2-3.3 (m, 6H), 2.45-2.6 (m, 4H), 2.2 (m, 2H), 1.1-1.6 (m, 14H), 0.8 (t, 3H), 0.70 (t, 3H) ppm.

›EXAMPLE 472

[3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-5-ethyl-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the 1-[4-(3-diethylamino-propoxy)-phenyl]-butane-1-one (1.08 mmol) in anhydrous MeOH (15 mL), pyrrolidone hydrotribromide (1.6 eq.) was added, according to General Procedure R1. The reaction mixture was heated under reflux overnight. The solvent was then removed in vacuuo and the crude alpha-bromophenone was used for further transformation.

MS m/z 560 (M+H) + :

1 H NMR (CDCl 3 ): δ7.58 (d, 2H), 7.36 (d, 2H), 7.22 (d, 2H), 7.09 (d, 2H), 7.04 (d, 2H), 6.93 (d, 2H), 4.03 (t, 2H), 2.56 (m, 10H), 1.94 (m, 2H), 1.59 (m, 2H), 1.27 (m, 2H), 1.03 (t, 6H,), 0.97 (t, 3H), 0.82 (t, 3H) ppm.

›EXAMPLE 473

2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-4-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-imidazole

To a stirred solution of NaH (3 eq., 6.0 mmol) in DMF (10 mL) at rt, 4′-hydroxyacetophenone (2.2 mmol) was added. The mesylate of 1-(2-hydroxyethyl)-pyrrolidine (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alkylated product was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM. (yield 50-60%)

To a stirred solution of the alkoxyacetophenone described above (1 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 1.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (20 ml) and washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alpha-bromoacetophenone was used for further transformation.

To a stirred solution of 4-chloro-phenoxy aniline (1.2 eq., 1.2 mmol) in anhydrous DMF (10 mL) DIEA (3 eq. 3.0 mmol) was added, followed by slow addition of the alpha-bromoacetophenone described above (1.0 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated aniline described above (1.0 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 3.0 mmol) was added, followed by slow addition of valeryl chloride (2 eq., 2.0 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was purified using silica gel chromatography. Pure product was obtained from 3-4% MeOH/DCM (Yield 40-45%).

To a stirred solution of the amide described above (0.5 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 4-6% MeOH/DCM (yield: 105 mg).

MS m/z 516 (M) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.34 (d, 2H), 7.29 (d, 2H), 7.09 (s, 1H), 7.05 (m, 4H), 6.95 (d, 2H), 4.19 (t, 2H), 3.05 (t, 2H), 2.84 (m, 4H), 2.77 (t, 2H), 1.89 (m, 4H), 1.65 (m, 2H), 1.34 (m, 2H), 0.85 (t, 3H) ppm

›EXAMPLE 474

1-[2-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-ethyl]-piperidine

To a stirred solution of NaH (3 eq., 6.0 mmol) in DMF (10 mL) at rt, 4′-hydroxyacetophenone (2.2 mmol) was added. The mesylate of 1-(2-hydroxyethyl)-piperidine (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alkylated product was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM. (yield 50-60%)

MS m/z 530 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.49 (d, 2H), 7.34 (d, 2H), 7.15 (d, 2H), 6.97 (s, 1H), 6.93 (m, 4H), 6.84 (d, 2H), 4.18 (t, 2H), 3.33 (m, 4H), 2.81 (t, 2H), 2.68 (t, 2H), 1.67 (m, 2H), 1.55 (m, 2H), 1.37 (m, 2H), 1.02 (m, 4H) 0.65 (t, 3H) ppm

›EXAMPLE 475

[3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-2,2-dimethyl-propyl]-dimethyl-amine

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (8.0 mmol) was added. The mesylate of 3-dimethylamino-2,2-dimethyl-1-propanol (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alkylated product was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM. (yield 50-60%)

To a stirred solution of the alkoxyacetophenone described above (1 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 1.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate and the product was isolated in EtOAc. The combined organic layers were washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alpha-bromoacetophenone was used for further transformation.

To a stirred solution of 4-chloro-phenoxy aniline (1.2 eq., 1.2 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 3.0 mmol) was added, followed by slow addition of the alpha-bromoacetophenone described above (1.0 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

MS m/z 532 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ7.69 (d, 2H), 7.34 (d, 2H), 7.29 (d, 2H), 7.09 (s, 1H), 7.06 (d, 2H), 7.02 (d, 2H), 6.93 (d, 2H), 3.75 (s, 2H), 2.68 (t, 2H), 2.42 (s, 2H), 2.35 (s, 6H), 1.65 (m, 2H), 1.29 (m, 2H), 1.05 (s, 6H), 0.85 (t, 3H) ppm

›EXAMPLE 476

[2-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-ethyl]-diisopropyl-amine

To a stirred solution of 4′-hydroxyacetophenone (2.2 mmol) in DMF (10 mL) at rt, solid potassium carbonate (8.0 mmol) was added. The mesylate of 2-(diisopropylamino)ethanol (prepared from the corresponding alcohol and methanesulfonyl chloride) (2.0 mmol) was added to the reaction mixture and heated to 80° C. until completion according to General Procedure Q1, as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was diluted with water and the product was isolated in EtOAc. The combined organic layers were washed with saturated sodium bicarbonate (2×15 ml), water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alkylated product was purified using silica gel column chromatography. Pure product was obtained with 2-3% MeOH/DCM. (yield 50-60%)

To a stirred solution of the alkoxyacetophenone described above (1 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 1.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate and the product was isolated in EtOAc. The combined organic layers were washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alpha-bromoacetophenone was used for further transformation.

The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

MS m/z 546 (M+H) + :

›EXAMPLE 477

[3-(4-{4-[4-(adamantan-1-ylmethoxy)-phenyl]-2-isobutyl-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

A stirred solution of the 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. After the addition, the mesylate of 1-adamantylmethanol (1.1 eq) was added to the reaction mixture, and stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography with 5-10% MeOH/DCM (yield 60 mg).

MS m/z 570 (M+H) + :

1 H NMR (CDCl 3 ): δ7.68 (d, 2H), 7.20 (d, 2H), 7.09 (s, 1H), 6.97 (d, 2H), 6.90 (d, 2H), 4.06 (t, 2H), 3.5 (s, 2H), 2.6 (t, 2H), 2.58 (q, 4H), 2.52 (d), 1.6-2.1 (m, 18H), 1.05 (t, 6H), 0.85 (d, 6H) ppm.

›EXAMPLE 478

{3-[4-(4-{4-[3-(2,6-dichloro-phenyl)-4-methyl-isoxazol-5-ylmethyloxy]-phenyl}-2-isobutyl-imidazol-1-yl)-phenoxy]-propyl}-diethyl-amine

To a stirred solution of the amide described above (0.88 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the cyclized product, (crude˜80%) which was taken to the next transformation without purification.

To a stirred solution of the 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) obtained above in anhydrous DMF (5.0 mL) solid sodium hydride (60% dispersion in oil; 1.0 mmol) was added in portions. After the addition, the requisite alkylhalide or the mesylate (prepared from the corresponding alcohol and methanesulfonyl chloride) (1.1 eq) was added to the reaction mixture. The reaction mixture was stirred at rt overnight. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure product was obtained from 5-10% MeOH/DCM (yield 57 mg).

MS m/z 661 (M+H) + :

1 H NMR (CDCl 3 ): δ 7.65 (d, 2H), 7.2-7.44 (m, 5H), 7.08 (s, 1H), 6.96 (d, 2H), 677 (d, 2H), 4.74 (s, 2H), 4.13 (t, 2H), 2.9-3.15 (m, 6H), 2.6 (s, 3H), 2.51 (d, 2H), 2.3 (m, 3H), 1.35 (t, 6H), 0.83 (t, 6H) ppm

›EXAMPLE 479

[3-(4-{4-[4-(4-bromo-benzyloxy)-phenyl]-2-isobutyl-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of the amide described above (0.88 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. overnight. The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the cyclized product, (crude˜80%) which was taken to the next transformation without purification.

A stirred solution of the 4-{1-[4-(3-diethylamino-propoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenol (1.0 eq) in anhydrous DMF (5.0 mL) was treated with solid sodium hydride (60% dispersion in oil; 1.0 mmol) in portions. The mesylate of (4-bromophenyl)methanol (1.1 eq) was added to the reaction mixture, and stirred at rt overnight, according to General Procedure T3. Et 2 O (30 mL) was added to the reaction mixture followed by H 2 O (10 mL). The organic layer was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. The solvent was removed in vacuuo. Pure imidazole was obtained from chromatography with 5-10% MeOH/DCM (yield 95 mg).

MS m/z 591 (M+H) + :

1 H NMR (CDCl 3 ): δ7.7 (d, 2H), 7.5 (d, 2H), 7.32 (d, 2H), 7.21 (d, 2H), 7.11 (s, 1H), 6.96 (m, 4H), 5.03 (s, 2H), 4.07 (t, 2H), 2.5-2.8 (m, 8H), 2.0 (m, 3H), 1.07 (t, 6H), 0.84 (d, 6H) ppm.

›EXAMPLE 480

[3-(4-{2-butyl-1-[4-(6-methoxy-naphthalen-2-yloxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 6-methoxy-2-naphthol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 mL), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(6-methoxy-naphthalen-2-yloxy)-1-nitrobenzene. The crude product was used for further transformation.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(6-methoxy-naphthalen-2-yloxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (4.6 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 5.5 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of an 4-(6-methoxy-naphthalen-2-yloxy)aniline (5 mmol) in anhydrous DMF (20 mL) DIEA (15 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (4.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation without additional purification.

To a stirred solution of alkylated 4-(6-methoxy-naphthalen-2-yloxy)aniline described above (4.6 mmol) in anhydrous DCM (10 mL) at 0° C., TEA (3 eq., 15 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 15 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the N-alkylated anilide (˜4.6 mmol) obtained as above in acetic acid (10 mL), solid ammonium acetate (92 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×40 mL). The combined organic layers was washed with H 2 O (2×40 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 500 mg).

MS m/z 578 (M+H) + :

1 H NMR (CDCl 3 ): δ8.51 (d, 1H), 8.42 (m, 1H), 8.31 (d, 1H), 7.75 (m, 2H), 7.62 (m, 2H) 7.37 (s, 1H), 7.23 (m, 2H), 7.12 (m, 2H), 7.08 (s, 1H), 6.97-6.79 (m, 2H), 3.98 (t, 2H), 3.41 (s, 3H), 3.23-3.05 (m, 6H), 2.75 (m, 2H), 2.45 (m, 2H), 1.75-1.48 (m, 4H), 1.37 (t, 6H), 0.80 (m, 3H) ppm.

›EXAMPLE 481

[3-(4-{2-butyl-1-[4-(naphthalen-2-yloxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 2-naphthol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 mL), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(naphthalen-2-yloxy)-1-nitrobenzene. The crude product was used for further transformation.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOH (50 mL) and hydrogenated in the presence of 10% Pd/C (300 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(naphthalen-2-yloxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of 4-(naphthalen-2-yloxy)aniline (1.2 eq., 5 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 15 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (4.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation without additional purification.

To a stirred solution of alkylated 4-(naphthalen-2-yloxy)aniline described above (4.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 15 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 15 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the N-alkylated anilide (˜4.6 mmol) obtained as above in acetic acid (10 mL), solid ammonium acetate (92 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×50 mL). The combined organic layers was washed with H 2 O (50 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 170 mg).

MS m/z 548 (M+H) + :

1 H NMR (CDCl 3 ): δ7.91 (t, 1H), 7.84 (t, 1H), 7.77 (m, 1H), 7.71 (m, 2H) 7.56-7.42 (m, 4H), 7.32 (m, 2H), 7.18 (s, 1H), 7.16-7.03 (m, 2H), 7.00-6.86 (m, 2H), 4.02 (t, 2H), 3.00-2.76 (m, 6H), 2.70 (m, 2H), 2.12 (m, 2H), 1.44-1.28 (m, 4H), 1.23 (t, 6H), 0.93 (m, 3H) ppm.

›EXAMPLE 482

2-butyl-4-[4-(4-ethyl-hexyloxy)-phenyl]-1-[4-(4-methoxy-naphthalen-1yl-oxy)-phenyl]-1H-imidazole

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-methoxy-1-naphthol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 mL), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-methoxynaphthalen-1-yloxy)-1-nitrobenzene. The crude product was used for further transformation.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(4-methoxy-naphthalen-1-yloxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (2.3 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 2.7 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of 4-(4-methoxy-naphthalen-1-yloxy)aniline (1.2 eq., 2.5 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 7.5 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2.3 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated 4-(4-methoxynaphthalen-1-yloxy)aniline described above (2.3 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 7.5 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 7.5 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the N-alkylated anilide (2.3 mmol) obtained as above in acetic acid (5 mL), solid ammonium acetate (46 mmol) was added in one portion, according to General Procedure R4. The reaction mixture was then heated to 100° C. overnight. The reaction mixture was cooled to rt, and treated with saturated aqueous sodium bicarbonate solution while stirring to until the pH was 7-8. The contents were extracted with EtOAc (2×30 mL). The combined organic layers was washed with H 2 O (2×30 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 213 mg).

MS m/z 578 (M+H) + :

1 H NMR (CDCl 3 ): δ8.35 (dd, 1H), 7.60 (dd, 1H), 7.72 (m, 2H), 7.55 (m, 2H), 7.24 (s, 1H), 7.23 (m, 2H), 7.15 (t, 1H), 7.04 (m, 2H), 6.90 (m, 2H), 6.80 (d, 1H), 4.04 (s, 3H), 3.95 (t, 2H), 3.00-2.87 (m, 6H), 2.67 (t, 2H), 2.10 (m, 2H), 1.65 (m, 2H), 1.38 (m, 2H), 1.21 (t, 6H), 0.95 (m, 3H) ppm.

›EXAMPLE 483

[3-(4-{2-butyl-1-[4-(dibenzofuran-2-yloxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 2-hydroxydibenzofuran (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 mL), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(dibenzofuran-2-yloxy)-1-nitrobenzene. The crude product was used for further transformation.

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(dibenzofuran-2-yloxy)aniline, which was used directly for further transformation without further purification.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (2.3 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq, 2.7 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of 4-(dibenzofuran-2-yloxy)aniline (1.2 eq., 2.5 mmol) in anhydrous DMF (5 mL) DIEA (3 eq. 7.5 mmol) was added, followed by slow addition of the 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone described above (2.3 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold H 2 O and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated 4-(dibenzofuran-2-yloxy)aniline described above (˜2.3 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 7.5 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 7.5 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

MS m/z 588 (M+H) + :

1 H NMR (CDCl 3 ): δ7.92 (d, 1H), 7.71 (m, 2H), 7.62 (d, 2H), 7.51 (t, 1H), 7.37 (t, 1H), 7.32-7.26 (m, 3H), 7.23 (m, 2H), 7.16 (s, 1H), 7.13-7.09 (m, 1H), 6.91 (d, 2H), 4.08 (t, 2H), 2.97-2.75 (m, 6H), 2.69 (t, 2H), 2.19 (m, 2H), 1.69 (m, 2H), 1.39-1.25 (m, 2H), 1.29 (t, 6H), 0.89 (t, 3H) ppm.

›EXAMPLE 484

6-(4-{2-butyl-4-[4-(3-diethylamino-propoxy)-phenyl]-imidazol-1-yl}-phenoxy)-naphthalen-2-ol

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 6-methoxy-2--naphthol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into H 2 O (100 mL), extracted with EtOAc (2×50 mL), washed with H 2 O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(6-methoxy-2-naphthalen-2-yloxy)-1-nitrobenzene. The crude product was used for further transformation.

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (4.6 mmol) in anhydrous MeOH (10 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 5.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was used for further transformation.

To a stirred solution of alkylated 4-(6-methoxy-2-naphthalenoxy)aniline described above (4.6 mmol) in anhydrous DCM (10 mL) at 0° C., TEA (3 eq., 15 mmol) was added, followed by slow addition of valeryl chloride (3 eq., 15 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

The N-aryl imidazole (0.12 mmol) previously described was dissolved in 5 mL of 48% aqueous HBr and heated to 90° C. for 36 h until the reaction was complete by HPLC. The reaction mixture was cooled to rt and treated with ice-cold saturated aqueous sodium bicarbonate solution until pH 8. The mixture was extracted with EtOAc (2×15 mL). The combined organic layers was washed with H 2 O (2×15 mL) and brine, and dried over sodium sulfate. Evaporation of the solvent in vacuuo afforded the demethylated N-aryl imidazole. The crude product was purified using silica gel column chromatography (2-5% MeOH/DCM) (yield 20 mg).

MS m/z 564 (M+H) + :

1 H NMR (CDCl 3 ): δ7.62 (d, 2H), 7.60 (s, 1H), 7.58-7.54 (m, 2H), 7.32 (d, 1H), 7.18 (s, 1H), 7.16 (d, 1H), 7.15-7.10 (m, 2H), 7.08 (s, 1H), 7.02 (d, 2H), 6.78 (d, 2H), 3.95 (t, 2H), 3.00-2.81 (m, 6H), 2.60 (t, 2H), 2.12 (m, 2H), 1.56 (m, 2H), 1.30 (t, 2H), 1.21 (t, 6H), 0.75 (t, 3H) ppm.

›EXAMPLE 485

[3-(4-{2-butyl-4-[4-(4-chloro-phenoxy)-phenyl]-imidazol-1-yl}-phenoxy)-propyl]-diethyl-amine

A mixture of 4-fluoroacetophone (50 mmol), 4-chlorophenol (75 mmol, 1.5 eq), cesium carbonate (150 mmol, 3 eq) and anhydrous DMSO (80 mL) was heated with stirring at 90° C. for 20 h (monitored by TLC). After cooling to rt, the reaction mixture was treated with cold H 2 O (150 mL), and the resulting mixture was extracted with ether (4×100 mL). The combined organic layers were washed with 2N NaOH (4×100 mL), H 2 O (2×100 mL) and brine (100 mL), and dried over anhydrous sodium sulfate. The crude 1-[4-(4-chlorophenoxy)phenyl]ethanone was purified by flash chromatography (eluting with 5-10% EtOAc in hexane) to give 4-(4′-chlorophenoxy)acetophone as an almost colorless solid (yield: 80%).

To a stirred solution of 4-fluoronitrobenzene (50 mmol) and 3-diethylaminoproanol (70 mmol) dissolved in anhydrous THF (50 mL) at 0° C. and under a nitrogen stream was added KOBu t (70 mmol) in portions, and the reaction mixture was allowed to warm to rt, and stirred overnight, according to General Procedure L1. The reaction mixture was then treated with cold H 2 O (80 mL), and extracted with EtOAc (3×100 mL). The combined organic layers were washed with brine (2×60 mL) and dried over anhydrous sodium sulfate. Evaporation of the solvent in vacuuo afforded the desired N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine, which was used for further transformation without further purification (yield: ˜98%).

The crude N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (˜33 mmol) was dissolved in MeOH (50 mL), and hydrogenated in the presence of 10% Pd/C (0.8 g) until the reaction was complete as indicated by LC-MS (˜4 h), according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed under high vacuum to afford N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine which was used directly for further transformation without further purification (yield: ˜96%).

1-[4-(4-chlorophenoxy)phenyl]ethanone (24 mmol) was dissolved in 1,4-dioxane (100 mL), and pyridine hydrotribromide (25.2 mmol, 1.05 eq) was added, according to General Procedure R1. After being stirred at rt for 7 h (monitored by TLC), the reaction was quenched with cold H 2 O (100 mL). The resulting mixture was extracted with ether (4×100 mL). The combined ether extracts were washed with brine (3×50 mL), and dried over anhydrous sodium sulfate. The solvent was then removed in vacuuo and the crude 2-bromo-1-[4-(4-chlorophenoxy)phenyl]ethanone was directly used for further transformation.

To a stirred solution of ice-cold N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (22 mmol, 1.1 eq) dissolved in DCM (40 mL) was added dropwise a solution of the 2-bromo-1-[4-(4-chlorophenoxy)phenyl]ethanone (20 mmol) dissolved in DMF (30 mL), according to General Procedure R2. The mixture was stirred at 0° C. for 3 h, and then allowed to warm to rt, continuing the stirring for additional 2 h (monitored by LC-MS). The reaction mixture was treated with saturated sodium bicarbonate (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (overall yield from 1-[4-(4-chlorophenoxy)phenyl]ethanone: 60%).

To a stirred solution of the alkylated aniline described above (10 mmol) dissolved in anhydrous DCM (100 mL) at 0° C., TEA (40 mmol, 4 eq) was added, followed by a slow addition of valeryl chloride (20 mmol, 2 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 2 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

The crude amide described above (˜6 mmol) was suspended in acetic acid (10 mL), and ammonium acetate (excess, ˜30 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. for 6 h (as monitored by LC-MS). The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate and solid sodium carbonate. The resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with H 2 O (2×60 mL) and brine (2×60 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA affording Example 485.

MS m/z 532 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ0.83 (t, 3H), 1.04 (t, 6H), 1.28 (m, 2H), 1.63 (m, 2H), 1.96 (m, 2H), 2.56 (q, 4H), 2.61-2.65 (m, 4H), 4.06 (t, 2H), 6.93 (d, 2H), 6.98 (d, 2H), 7.00 (d, 2H), 7.16 (s, 1H), 7.22 (d, 2H), 7.26 (d, 2H), 7.76 (d, 2H) ppm.

›EXAMPLE 486

[3-(4-{2-(4-tert-butyl-cyclohexyl)-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-{4-[3-(diethylamino)propoxy]phenyl}ethanone (80 mmol) in MeOH (200 mL) at rt, pyrrolidone hydrotribromide (96 mmol, 1.2 eq) was added in portions at rt, according to General Procedure R1. The reaction mixture was stirred at rt for 2 h (monitored by LC-MS). The solvent was then removed in vacuuo and the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone was directly used for further transformation.

The solution of the crude 2-bromo-1-{4-[3-(diethylamino)propoxy]phenyl}ethanone dissolved in anhydrous DMF (180 mL) was chilled to 0° C., and 4-(4′-chlorophenoxy)aniline (88 mmol, 1.1 eq) was added, followed by slowly adding DIEA (240 mmol, 3 eq), according to General Procedure R2. After being stirred at 0° C. for 1 h and at rt for additional 4 h, the reaction mixture was treated with saturated sodium bicarbonate (250 mL). The resulting mixture was extracted with EtOAc (4×200 mL). The combined EtOAc extracts were washed with brine (3×100 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA.

Oxayl chloride (420 mmol, 3 eq) was added slowly to an ice-cold solution of 4-t-butylcyclohexanecarboxylic acid (140 mmol) dissolved in anhydrous DCM (80 mL), and the reaction mixture was stirred at 0° C. for 3 h and at rt for additional 3 h. The solvent was removed in vacuuo, and the resulting acid chloride was pumped under high vacuum for about 30 min, and used for next step reaction without further purification.

To a stirred solution of the 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone described above (35 mmol) dissolved in anhydrous DCM (200 mL) at 0° C., TEA (140 mmol, 4 eq) was added, followed by a slow addition of the freshly prepared acid chloride (70 mmol, 2 eq). The reaction mixture was stirred under nitrogen at 0° C. for 2 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

The crude amide described above (˜35 mmol) was suspended in acetic acid (50 mL), and ammonium acetate (excess, ˜30 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. for 6 h (as monitored by LC-MS). The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate and solid sodium carbonate. The resulting mixture was extracted with EtOAc (4×200 mL). The combined EtOAc extracts were washed with H 2 O (2×100 mL) and brine (2×100 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the crude product was purified by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA affording the title compound as cis/trans (1:2 ratio) mixture (yield 14.5 g).

LC: 1.06 min; MS: m/z 614 (M+H) +

›EXAMPLE 487

[3-{4-[1-[4-(4-chloro-phenoxy)-phenyl]-2-(4-ethyl-cyclohexyl)-1H-imidazol-4-yl]-phenoxy}-propyl)-diethyl-amine

Oxayl chloride (3 mmol, 3 eq) was added slowly to an ice-cold solution of trans-4-ethylcyclohexanecarboxylic acid (1 mmol) dissolved in anhydrous DCM (5 mL), and the reaction mixture was stirred at 0° C. for 2 h and at rt for additional 1 h. The solvent was removed in vacuuo, and the resulting acid chloride was pumped under high vacuum for about 30 min, and used without further purification.

To a stirred solution of the 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone (0.3 mmol) described above dissolved in anhydrous DCM (10 mL) at 0° C., TEA (1.2 mmol, 4 eq) was added, followed by slow addition of the freshly prepared acid chloride (˜1 mmol, ˜3 eq). The reaction mixture was stirred under nitrogen at 0° C. for 2 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

To a stirred solution of the amide described above (˜0.3 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜30 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. for 3 h (as monitored by LC-MS). The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate. The resulting mixture was extracted with EtOAc (3×50 mL). The combined EtOAc extracts were washed with brine (3×20 ml), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the pure product was obtained by silica gel column chromatography eluting with 10% MeOH/EtOAc+0.2% Et 3 N (yield 123 mg).

MS m/z 586 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ0.85 (t, 3H), 1.06 (t, 6H), 1.16-1.82 (m, 12H), 1.96 (m, 2H), 2.61 (q, 4H), 2.68 (t, 2H), 4.01 (t, 2H), 6.89 (d, 2H), 7.03 (d, 2H), 7.06 (d, 2H), 7.08 (s, 1H), 7.27 (d, 2H), 7.35 (d, 2H), 7.68 (d, 2H) ppm.

›EXAMPLE 488

[4-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-phenyl]-(1-ethyl-piperidin-4ylmethyl)-amine

To a stirred solution of the 4′-(4-nitro-phenoxy)acetophenone (2 mmol) in anhydrous MeOH (5 mL) at 0° C., pyrrolidone hydrotribromide (1.2 eq., 2.2 mmol) was added, according to General Procedure R1. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and was allowed to warm to rt until completion, as indicated by TLC or HPLC. The solvent was then removed in vacuuo and the residue was treated with saturated sodium bicarbonate. The aqueous layer was poured into EtOAc (20 ml) and washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulfate, and the solvent was removed in vacuuo to afford the desired product. The crude alpha-bromoacetophenone was used for further transformation.

To a stirred solution of the 4-chloro-phenoxy aniline (1.2 eq., 2.2 mmol) in anhydrous DMF (10 mL) DIEA (3 eq. 6 mmol) was added, followed by slow addition of the alpha-bromoacetophenone described above (1.6 mmol), according to General Procedure R2. The reaction mixture was stirred under nitrogen at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with cold water and the product was isolated in EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation of solvent in vacuuo afforded the desired product. The crude alkylated aniline was used for further transformation.

To a stirred solution of alkylated aniline described above (1.6 mmol) in anhydrous DCM (5 mL) at 0° C., TEA (3 eq., 4.8 mmol) was added, followed by slow addition of valeryl chloride (2 eq., 3.2 mmol), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then diluted with water and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude aimide was used for further transformation.

To a stirred solution of the amide described above (1 mmol) in acetic acid (2 mL), ammonium acetate (excess, ˜20 eq.) was added, according to General Procedure R4. The reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to rt and neutralized with saturated sodium bicarbonate solution. Usual extractive work up with EtOAc gave the cyclized imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 30-40% ethylacetate/hexane (yield 50-55%).

The cyclized imidazole intermediate obtained above (0.5 mmol) obtained above was dissolved in MeOH (5 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired reduced imidazole, which was used directly for further transformation without further purification.

To a stirred solution of N-Boc-4-piperidineacetic acid (1.2 eq., 0.6 mmol) in anhydrous DCM (2 mL) was added DCC-PS (1.5 eq., 0.75 mmol). The solution was allowed to shake at rt for 20-30 min. This was followed by addition of the reduced cyclized imidazole described above (0.5 mmol). The reaction mixture was shaken overnight at rt until completion, as indicated by TLC or HPLC. The reaction mixture was then filtered and the product was isolated in DCM. The solvent was removed in vacuuo, and the crude amide was used for further transformation.

To a stirred solution of the amide described above (0.5 mmol) in anhydrous THF (2 mL) at 0° C., borane/THF (3 eq, 1.5 mmol) was added. The reaction mixture was stirred under nitrogen at 0° C. for 1 h and allowed to warm to rt until completion, as indicated by TLC or HPLC. The reaction mixture was then cooled to rt and the solvent was removed in vacuuo to give the product imidazole, which was purified by column chromatography (Silica gel). Pure product was obtained from 3-4% MeOH/DCM (yield 150 mg).

MS m/z 635 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ 8.01 (s, 1H), 7.84 (d, 2H), 7.65 (d, 2H), 7.59 (d, 2H), 7.44 (d, 2H), 7.22 (m, 6H), 7.12 (d, 2H), 3.65 (d, 2H), 3.45 (d, 2H), 3.03 (t, 2H), 3.18 (m, 2H), 2.98 (m, 4H), 2.15 (m, 2H), 1.71 (m, 3H), 1.39 (m, 5H), 0.85 (t, 3H) ppm

›EXAMPLE 489

[4-{1-[4-(4-chloro-phenoxy)-phenyl]-4-[4-(3-diethylaminopropoxy)-phenyl]-1H-imidazol-2-yl}-butyric acid methyl ester

As described in Example 406, 2-[4-(4-chlorophenoxy)-phenylamino]-1-[4-(3-diethylamino-propoxy)-phenyl]-ethanone (0.5 mmol) was dissolved in anhydrous DCM (10 mL) and cooled to 0° C. TEA (2 mmol, 4 eq) was added to the reaction mixture, followed by slow addition of methyl 4-(chloroformyl)butyrate (1.5 mmol, 3 eq), according to General Procedure R3. The reaction mixture was stirred under nitrogen at 0° C. for 2 h and allowed to warm to rt until completion, as indicated by LC-MS. The solvent was removed in vacuuo, and the crude amide was used directly for further transformation.

To a stirred solution of the amide described above in acetic acid (2 mL), ammonium acetate (excess, ˜30 eq) was added, according to General Procedure R4. The reaction mixture was stirred at 100° C. for 3 h (as monitored by LC-MS). The reaction mixture was then cooled down and neutralized with saturated sodium bicarbonate. The resulting mixture was extracted with EtOAc (3×50 mL). The combined EtOAc extracts were washed with brine (3×20 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo, and the pure product was obtained by silica gel column chromatography eluting with 10% MeOH in EtOAc+0.2% TEA (yield: ˜70%) (yield 202 mg).

MS m/z 576 (M+H) + :

1 H NMR (400 MHz, CDCl 3 ): δ1.04 (t, 6H), 1.94 (m, 2H), 2.02 (m, 2H), 2.39 (t, 2H), 2.56 (q, 4H), 2.63 (t, 2H), 2.72 (t, 2H), 3.59 (s, 3H), 4.02 (t, 2H), 6.91 (d, 2H), 7.03 (d, 2H), 7.07 (d, 2H), 7.14 (s, 1H), 7.29 (d, 2H), 7.35 (d, 2H), 7.68 (d, 2H) ppm.

›EXAMPLE 490

[3-(4-{2-butyl-1-[4-(4-chloro-2-cyclohexyl-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (10 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-2-cyclohexylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (80 ml)

›Tables in the description — 14

wherein	A 3 comprises an aryl or heteroaryl group;	L 1 and L 2 independently comprise alkylene or alkenylene; and	L 3 comprises a direct bond, alkylene, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,
	wherein R 30 , R 31 , and R 32 independently comprise hydrogen, aryl, heteroaryl, alkyl, alkylene-aryl, or -alkylene-heteroaryl;

wherein;

R 19 and R 20 independently comprise hydrogen, aryl, alkyl, -alkylene-aryl, alkoxy, or -alkylene-O-aryl; and

R 18 comprises aryl, alkyl, -alkylene-aryl, -aikylene-heteroaryl, and -alkylene-O-aryl;

Y 3 and Y 5 independently comprise a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

wherein R 27 and R 26 independently comprise aryl, alkyl, -alkylene-aryl, alkoxy, or -alkyl-O-aryl;

Y 4 comprises

a) -alkylene;

b) -alkenylene;

c) -alkynylene;

d) -arylene;

e) -heteroarylene;

f) -cycloalkylene;

g) -heterocyclylene;

h) -alkylene-arylene;

i) -alkylene-heteroarylene;

j) -alkylene-cycloalkylene;

k) -alkylene-heterocyclylene;

l) -arylene-alkylene;

m) -heteroarylene-alkylene;

n) -cycloalkylene-alkylene;

o) -heterocyclylene-alkylene;

p) —O—;

q) —S—;

r) —S(O 2 )—; or

s) —S(O)—;

wherein said alkylene groups may optionally contain one or more O, S, S(O), or SO 2 atoms;

A 2 comprises

a) heterocyclyl, fused arylheterocyclyl, or fused heteroarylheterocyclyl, containing at least one basic nitrogen atom, b) -imidazolyl, or c) -pyridyl; and

R 23 , R 24 , and R 25 independently comprise hydrogen, aryl, heteroaryl, —alkylene-heteroaryl, alkyl, -alkylene-aryl, -alkylene-O-aryl, or -alkylene-O-heteroaryl; and R 23 and R 24 may be taken together to form a ring having the formula —(CH 2 ) s —X 3 —(CH 2 ) t — bonded to the nitrogen atom to which R 23 and R 24 are attached

wherein

s and t are, independently, 1, 2, 3, or 4; X 3 comprises a direct bond, —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,

wherein R 28 and R 29 independently comprise hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl;

wherein	A 3 comprises an aryl or heteroaryl group;	L 1 and L 2 independently comprise alkylene or alkenylene;	L 3 comprises a direct bond, alkylene, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,
	wherein R 30 , R 31 , and R 32 independently comprise hydrogen, aryl, heteroaryl, alkyl, alkylene-aryl, or -alkylene-heteroaryl;

wherein R 27 and R 26 independently comprise aryl, alkyl, -alkylene-aryl, alkoxy, or -alkyl-O-aryl;

Y 4 comprises

a) -alkylene;

b) -alkenylene;

c) -alkynylene;

d) -arylene;

e) -heteroarylene;

f) -cycloalkylene;

g) -heterocyclylene;

h) -alkylene-arylene;

i) -alkylene-heteroarylene;

j) -alkylene-cycloalkylene;

k) -alkylene-heterocyclylene;

l) -arylene-alkylene;

m) -heteroarylene-alkylene;

n) -cycloalkylene-alkylene;

t) -heterocyclylene-alkylene;

u) —O—;

v) —S—;

w) —S(O 2 )—; or

x) —S(O)—;

wherein said alkylene groups may optionally contain one or more O, S, S(O), or SO 2 atoms;

A 2 comprises

a) heterocyclyl, fused arylheterocyclyl, or fused heteroarylheterocyclyl, containing at least one basic nitrogen atom, b) -imidazolyl, or c) -pyridyl; and

wherein

wherein R 28 and R 29 independently comprise hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl.

wherein R 27 and R 26 independently comprise aryl, alkyl, -alkylene-aryl, alkoxy, or -alkyl-O-aryl;

Y 4 comprises

a) -alkylene;

b) -alkenylene;

c) -alkynylene;

d) -arylene;

e) -heteroarylene;

f) -cycloalkylene;

g) -heterocyclylene;

h) -alkylene-arylene;

i) -alkylene-heteroarylene;

j) -alkylene-cycloalkylene;

k) -alkylene-heterocyclylene;

l) -arylene-alkylene;

m) -heteroarylene-alkylene;

n) -cycloalkylene-alkylene;

o) -heterocyclylene-alkylene;

p) —O—;

q) —S—;

r) —S(O 2 )—; or

s) —S(O)—;

wherein said alkylene groups may optionally contain one or more O, S, S(O), or SO 2 atoms;

A 2 comprises

a) heterocyclyl, fused arylheterocyclyl, or fused heteroarylheterocyclyl, containing at least one basic nitrogen atom, b) -imidazolyl, or c) -pyridyl;

R 23 , R 24 , and R 25 independently comprise hydrogen, aryl, heteroaryl, -alkylene-heteroaryl, alkyl, -alkylene-aryl, -alkylene-O-aryl, or -alkylene-O-heteroaryl; and R 23 and R 24 may be taken together to form a ring having the formula —(CH 2 ) s —-X 3 —(CH 2 ) t — bonded to the nitrogen atom to which R 23 and R 24 are attached

wherein

s and t are, independently, 1, 2, 3, or 4; X 3 comprises direct bond, —CH 2 —, —O—, —S—, —S(02)—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —,-SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—,

wherein R 28 and R 29 independently comprise hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl.

wherein R 19 and R 20 independently comprise hydrogen, aryl, alkyl, -alkylene-aryl, alkoxy, or -alkylene-O-aryl; and

R 18 comprises aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, and -alkylene-O-aryl;

Y 5 comprises a direct bond, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—,

wherein R 27 and R 26 independently comprise aryl, alkyl, -alkylene-aryl, alkoxy, or-alkyl-O-aryl;

Y 4 comprises

a) -alkylene;

b) -alkenylene;

c) -alkynylene;

d) -arylene;

e) -heteroarylene;

f) -cycloalkylene;

g) -heterocyclylene;

h) -alkylene-arylene;

i) -alkylene-heteroarylene;

j) -alkylene-cycloalkylene;

k) -alkylene-heterocyclylene;

l) -arylene-alkylene;

m) -heteroarylene-alkylene;

n) -cycloalkylene-alkylene;

o) -heterocyclylene-alkylene;

p) —O—;

q) —S—;

r) —S(O 2 )—; or

s) —S(O)—;

wherein R 27 and R 26 independently comprise aryl, alkyl, -alkylene-aryl, alkoxy, or-alkyl-O-aryl;

Y 4 comprises

a) -alkylene;

b) -alkenylene;

c) -alkynylene;

d) -arylene;

e) -heteroarylene;

f) -cycloalkylene;

g) -heterocyclylene;.

h) -alkylene-arylene;

i) -alkylene-heteroarylene;

j) -alkylene-cycloalkylene;

k) -alkylene-heterocyclylene;

l) -arylene-alkylene;

m) -heteroarylene-alkylene;

n) -cycloalkylene-alkylene;

o) -heterocyclylene-alkylene;

p) —O—;

q) —S—;

r) —S(O 2 )—; or

s) —S(O)—;

wherein said alkylene groups may optionally contain one or more O, S, S(O), or SO 2 atoms;

A 2 comprises

a) heterocyclyl, fused arylheterocyclyl, or fused heteroarylheterocyclyl, containing at least one basic nitrogen atom, b) -imidazolyl, or c) -pyridyl;

wherein

wherein R 28 and R 29 independently comprise hydrogen, aryl, heteroaryl, alkyl, -alkylene-aryl, or -alkylene-heteroaryl.

Example	Name
6	1-butyl-6-(4-tert-butyl-phenoxy)-2-[2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-1H-benzimidazole
7	1-butyl-2-[3-(naphthalen-2-yloxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
8	2-biphenyl-4-yl-1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzimidazole
9	1-butyl-6-(4-tert-butyl-phenoxy)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-1H-benzimidazole
10	1-butyl-2-[3-(3,3-dimethyl-butoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
11	1-butyl-6-(4-fluoro-3-trifluoromethyl-phenoxy)-2-[4-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-1H-benzimidazole
12	1-butyl-2-(3-phenoxy-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzoimidazole
13	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-piperidin-1-yl-
	ethoxy)-1H-benzimidazole
14	1-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-6-(2-piperidin-1-yl-
	ethoxy)-1H-benzimidazole
15	1-butyl-6-[2-(4-chloro-phenyl)-ethoxy]-2-[4-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-1H-benzimidazole
16	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-piperidin-1-yl-
	ethoxy)-1H-benzimidazole
17	1-butyl-2-(4-tert-butyl-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzoimidazole
18	dibutyl-{4-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-
	yl]-phenyl}-amine
19	(2-{3-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-3H-benzoimidazol-5-yloxy}-ethyl)-
	diisopropyl-amine
20	{3-[3-butyl-2-(4-tert-butyl-phenyl)-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
21	1-butyl-2-(3,5-di-tert-butyl-2-methoxy-phenyl)-6-(2-piperazin-1-
	ylethoxy)-1H-benzoimidazole
22	{3-[3-butyl-2-(3-{4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl}-propyl)-
	3H-benzimidazol-5-yloxy]-propyl}-diethyl-amine
23	1-butyl-2-naphthalen-2-yl-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzimidazole
24	(2-{3-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-3H-benzoimidazol-5-
	yloxy}-ethyl)-dimethyl-amine
25	2-benzofuran-2-yl-1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzimidazole
26	1-butyl-6-(2-piperazin-1-yl-ethoxy)-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazole
27	2-benzhydryl-1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-benzimidazole
28	1-Butyl-2-(4-chloro-phenyl)-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzoimidazole
29	{3-[3-Butyl-2-(4-isopropoxy-phenyl)-3H-benzoimidazol-5-yloxy]-
	propyl}-diethyl-amine
30	1-Butyl-6-(2-piperazin-1-yl-ethoxy)-2-[3-(4,4,4-trifluoro-butoxy)-
	phenyl]-1H-benzoimidazole

Example	Name
40	[3-(3-butyl-2-{3-[2-(4-chloro-phenyl)-ethoxy]-4-nitro-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
41	[2-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-ethyl]-diethyl-amine
42	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(piperidin-4-ylmethoxy)-
	1H-benzoimidazole
43	1-butyl-2-{3-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
44	{3-[3-butyl-2-(2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
45	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzimidazole
46	1-butyl-6-[2-(4-butyl-piperazin-1-yl)-ethoxy]-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazole
47	{3-[3-butyl-2-(2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
48	(3-{3-butyl-2-[3-(4-methoxy-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy}-propyl)-diethyl-amine
49	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-diethylamino-
	ethoxy)-benzimidazol-1-yl]-propyl}-diethyl-amine
50	[3-(1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-1H-
	benzimidazol-4-yloxy)-propyl]-diethyl-amine
51	[3-(1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-1H-
	benzimidazol-5-yl)-propyl]-diethyl-amine
52	1-butyl-2-[3-(2-isopropyl-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
53	{3-[3-butyl-2-(2-{4-[3-(4-methoxy-phenyl)-propoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
54	{3-[3-butyl-2-(2-{4-[4-(4-methoxy-phenyl)-butoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
55	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-3-ethoxy-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
56	(3-{3-butyl-2-[3-(3-trifluoromethyl-phenoxy)-phenyl]-3H-benzimidazol-
	5-yloxy}-propyl)-diethyl-amine
57	1-butyl-2-[3-(4-chloro-phenoxy)-phenyl]-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
58	1-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
59	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(piperidin-4-yloxy)-
	1H-benzoimidazole
60	3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzoimidazol-5-yloxy)-1-aza-bicyclo[2.2.2]octane
61	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl)-6-(2,2,6,6,-
	tetramethyl-piperidin-4-yloxy)-1H-benzoimidazole
62	2-[3-(4-butoxy-phenoxy)-phenyl]-1-butyl-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
63	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
64	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3-(3-methyl-butyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
65	[3-(2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3-hexyl-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
66	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-diethylamino-
	ethoxy)-benzimidazol-1-yl]-propyl}-dimethyl-amine
67	1-butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-6-(2-
	piperazin-1-ylethoxy)-1H-benzoimidazole
68	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
69	{3-[2-(4-benzyloxy-3,5-dimethyl-phenyl)-3-butyl-3H-benzimidazol-5-
	yloxy]-propyl}-diethyl-amine
70	{3-[3-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy]-propyl}-diethyl-amine
71	1-butyl-6-[2-(4-methyl-piperazin-1-yl)-ethoxy]-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazole
72	1-butyl-6-[2-(4-isopropyl-piperazin-1-yl)-ethoxy]-2-[3-(3-
	trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazoie
73	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(3-piperazin-1-yl-
	propoxy)-1H-benzoimidazole
74	(3-{3-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy}-propyl)-diethyl-amine
75	1-butyl-2-[3-(3,4-dimethoxy-phenoxy)-phenyl]-6-(2-piperidin-4-yloxy)-
	1H-benzoimidazole
76	1-butyl-2-[3-(4-chloro-benzyloxy)-phenyl]-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
77	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
78	(3-{2-[2-(4-benzyloxy-phenyl)-ethyl]-3-butyl-3H-benzimidazol-5-yloxy}-
	propyl)-diethyl-amine
79	(3-{3-butyl-2-[2-(4-phenethyloxy-phenyl)-ethyl]-3H-benzimidazol-5-
	yloxy}-propyl)-diethyl-amine
80	{3-[3-butyl-2-(2-{4-[2-(4-fluoro-phenyl)-ethoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
81	[3-(3-butyl-2-{2-[4-(4-chloro-benzyloxy)-phenyl]-ethyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
82	(3-{3-butyl-2-[4-(4-fluoro-benzyloxy)-phenyl]-3H-benzimidazol-5-
	yloxy}-propyl)-diethyl-amine
83	{3-[2-(3-benzyloxy-phenyl)-3-butyl-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
84	[3-(3-butyl-2-{4-chloro-3-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
85	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzimidazole
86	1-butyl-2-[4-(4-isopropyl-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
87	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-[3-(4-methyl-
	piperazin-1-yl)-propoxy]-1H-benzoimidazole
88	1-butyl-6-[2-(4-butyl-piperazin-1-yl)-ethoxy]-2-{4-[2-(4-chloro-phenyl)-
	ethoxy]-phenyl}-1H-benzoimidazole
89	1-butyl-2-[3-(3,4-dimethoxy-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
90	1-butyl-2-[4-(4-tert-butyl-benzyl)-phenyl]-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
91	N-{4-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-2-[2-
	(4-chloro-phenyl)-ethoxy]-phenyl}-2,2-dimethyl-propioinamide
92	(3-{3-butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-3H-
	benzimidazol-5-yloxy}-propyl)-diethyl-amine
93	1-butyl-2-[4-(naphthalen-2-yloxy)-phenyl]-6-(2-piperazin-1-yl-ethoxy)-
	1H-benzoimidazole
94	1-butyl-2-[3-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-6-(2-
	piperazin-1-yl-ethoxy)-1H-benzoimidazole
95	[3-(3-butyl-2-{4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
96	4-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-2-[2-(4-
	chloro-phenyl)-ethoxy]-phenylamine
97	1-{4-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-2-[2-
	(4-chloro-phenyl)-ethoxy]-phenyl}-3-isopropyl-urea
98	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-dimethylamino-
	ethoxy)-benzimidazol-1-yl]-propyl}-dimethyl-amine
99	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-[2-(4-methyl-piperazin-1-
	yl)-ethoxy]-1H-benzimidazole
100	1-butyl-6-(4-cyclopentyl-phenoxy)-2-[4-(4-methyl-piperazin-1-
	ylmethyl)-phenyl]-1H-benzoimidazole
101	{3-[2-(4-benzyloxy-phenyl)-3-cyclopentylmethyl-3H-benzimidazol-5-
	yloxy]-propyl}-diethyl-amine
102	1-butyl-6-(4-butyl-phenoxy)-2-{3,5-dimethyl-4-[2-(1-methyl-pyrrolidin-
	2-yl)-ethoxy]-phenyl}-1H-benzoimidazole
103	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(3-pyrrolidin-1-yl-
	propoxy)-1H-benzoimidazole
104	{3-[2-(4-benzyloxy-phenyl)-3-isobutyl-3H-benzimidazol-5-yloxy]-
	propyl}-diethyl-amine
105	[3-(3-butyl-2-{3-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
106	1-butyl-6-(1-butyl-piperidin-4-yloxy)-2-[3-(3,5-dichloro-phenoxy)-
	phenyl]-1H-benzoimidazole
107	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(1-ethyl-piperidin-4-
	yloxy)-1H-benzoimidazole
108	1-butyl-6-(4-fluoro-3-trifluoromethyl-phenoxy)-2-[4-(4-methyl-
	piperazin-1-ylmethyl)-phenyl]-1H-benzoimidazole
109	diethyl-{3-[3-isobutyl-2-(2-{4-[2-(4-methoxy-phenyl)-ethoxy]-phenyl}-
	ethyl)-3H-benzimidazol-5-yloxy]-propyl}-amine
110	{3-[2-(2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-ethyl)-3-isobutyl-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
111	1-butyl-6-(2-piperazin-1-yl-ethoxy)-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazole
112	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzimidazole
113	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-[2-(4-methyl-
	piperazin-1-yl)-ethoxy]-1H-benzimidazole
114	{3-[2-(4-benzyloxy-phenyl)-3-cyclopentyl-3H-benzimidazol-5-yloxy)-
	propyl]-diethyl-amine
115	1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-5-(4-methyl-
	piperazin-1-ylmethyl)-1H-benzoimidazole
116	[2-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-ethyl]-dimethyl-amine
117	[2-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzimidazol-5-yloxy)-ethyl]-diisopropyl-amine
118	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-[2-(4-methyl-piperazin-
	1-yl)-ethoxy]-1H-benzimidazole
119	(3-{1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-1H-benzimidazol-4-
	yloxy}-propyl)-diethyl-amine
120	2-(3-butoxy-phenyl)-1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzimidazole
121	1-butyl-2-[3-(4-methanesulfonyl-benzyloxy)-phenyl]-6-(2-piperazin-1-
	yl-ethoxy)-1H-benzoimidazole
122	4′{3-[1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-
	phenoxy}-biphenyl-4-carbonitrile
123	{3-[2-(4-benzyloxy-phenyl)-3-butyl-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
124	1-Butyl-2-[4-(3-chloro-phenoxy)-phenyl]-6-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzoimidazole
125	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-[2-(4-isopropyl-
	piperazin-1-yl)-ethoxy]-1H-benzoimidazole
126	{3-[2-(3-benzyloxy-4-methoxy-phenyl)-3-butyl-3H-benzimidazol-5-
	yloxy)-propyl]-diethyl-amine
127	(3-{3-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy}-propyl)-diethyl-amine
128	{3-[3-butyl-2-(3-phenoxy-phenyl)-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
129	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-[2-(4-ethyl-piperazin-1-
	yl)-ethoxy]-1H-benzimidazole
130	1-butyl-2-[4-(2,3-di-methoxy-phenoxy)-phenyl]-6-(2-piperazin-1-
	ylethoxy)-1H-benzoimidazole
131	[3-(3-butyl-2-{2-[4-(4-chloro-benzyloxy)-phenyl]-ethyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
132	(3-{3-butyl-2-[3-(4-chloro-phenoxy)-phenyl]-3H-benzimidazol-5-yloxy}-
	propyl)-diethyl-amine
133	{3-[2-(4-benzyloxy-phenyl)-3-isopropyl-3H-benzimidazol-5-yloxy]-
	propyl}-diethyl-amine
134	(2-{3-butyl-2-[3-(3-trifluoromethyl-phenoxy)-phenyl]-3H-
	benzoimidazol-5-yloxy}-ethyl)-diisopropyl-amine
135	1-butyl-6-[2-(4-ethyl-piperazin-1-yl)-ethoxy]-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazole
136	{3-[3-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy]-propyl}-diethyl-amine
137	(3-{2-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-3H-benzimidazol-5-
	yloxy}-ethyl)-cyclohexyl-methyl-amine
138	1-butyl-6-[2-(4-propyl-piperazin-1-yl)-ethoxy]-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazole
139	1-butyl-6-(4-butyl-phenoxy)-2-[4-(4-methyl-piperazin-1-ylmethyl)-
	phenyl]-1H-benzoimidazole
140	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-morpholin-4-yl-
	ethoxy)-1H-benzimidazole
141	4-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-2-
	phenethyloxy-phenylamine
142	{2-[2-(4-benzyloxy-phenyl)-3-phenethyl-3H-benzimidazol-5-yloxy]-
	ethyl}-diethyl-amine
143	{3-[3-butyl-2-(4-phenoxy-phenyl)-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
144	3-[4-(2-{3-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-3H-benzimidazol-
	5-yloxy}-ethyl)-piperazin-1-yl]-propan-1-ol
145	1-butyl-6-(2-pyrrolidin-1-yl-ethoxy)-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazole
146	{2-[2-[4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-diethylamino-
	ethoxy)-benzimidazol-1-yl]-ethyl}-dimethyl-amine
147	1-butyl-6-(2-morpholin-4-yl-ethoxy)-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazole
148	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(1-methyl-piperidin-4-
	yloxy)-1H-benzoimidazole
149	N′-[3-butyl-2-(2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-ethyl)-3H-
	benzimidazol-5-yl]-N,N-diethyl-propane-1,3-diamine
150	1-butyl-2-[3-(2,4-dichloro-phenoxy)-phenyl]-6-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzimidazole
151	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-morpholin-4-yl-
	ethoxy)-1H-benzimidazole
152	1-butyl-6-(2-piperazin-1-yl-ethoxy)-2-[4-(4-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzoimidazole
153	2-[4-(biphenyl-4-yloxy)-phenyl]-1-butyl-6-(2-piperazin-1-yl-ethoxy)-1H-
	benzoimidazole
154	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-morpholin-4-yl-
	ethoxy)-1H-benzimidazole
155	1-butyl-2-[3-(3,4-dimethoxy-phenoxy)-phenyl]-6-(2-piperazin-1-yl-
	ethoxy)-1H-benzoimidazole
156	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-5-(1H-imidazol-4-
	ylmethoxy)-1H-benzoimidazole
157	{3-[2-(2-benzyloxy-phenyl)-3-butyl-3H-benzimidazol-5-yloxy]-propyl}-
	diethyl-amine
158	{3-[1-Butyl-6-(3-diethylamino-propoxy)-2-piperidin-4-yl-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
159	(2-{2-[2-(4-Benzyloxy-phenyl)-ethyl]-3-phenethyl-3H-benzoimidazol-
	5-yloxy}-ethyl)-diethyl-amine
160	[3-(3-Butyl-2-{3-[4-(4-fluoro-benzyloxy)-phenyl]-propyl)-3H-
	benzoimidazol-5-yloxy)-propyl]-diethyl-amine
161	[3-(4-Benzyloxy-phenyl)-propyl]-[1-butyl-6-(3-diethylamino-propoxy)-
	1H-benzoimidazol-2-yl]-amine
162	{3-[3-Butyl-2-(3-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-propyl)-3H-
	benzoimidazol-5-yloxy]-propyl}-diethyl-amine
163	1-Butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-imidazol-1-yl-
	ethoxy)-1H-benzoimidazole
164	1-[4-(2-{3-Butyl-2-[3-(3-trifluoromethyl-phenoxy)-phenyl]-3H-
	benzoimidazol-5-yloxy}-ethyl)-piperazin-1-yl]-ethanone
165	N-[3-Butyl-2-(2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-ethyl)-3H-
	benzoimidazol-5-yl]-N-(3-diethylamino-propyl)-N′,N′-diethyl-propane-
	1,3-diamine

Example	Name
171	{3-[2-[3-(3,5-Dichloro-phenoxy)-phenyl]-6-(3-diethylamino-propoxy)-
	1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
172	1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
173	{3-[2-[3-(3,4-Dichloro-phenoxy)-phenyl]-6-(3-diethylamino-propoxy)-
	1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
174	(3-{6-(3-diethylamino-propoxy)-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
175	{3-[1-Butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
176	{3-[2-[3-(4-Chloro-phenoxy)-phenyl]-6-(3-diethylamino-propoxy)-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
177	{3-[1-Butyl-2-[3-(4-chloro-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
178	{3-[1-Butyl-6-(3-diethylamino-propoxy)-2-(3-p-tolyloxy-phenyl)-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
179	{3-[1-Butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
180	1-Butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
181	{3-[3-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-7-(2-pyrrolidin-1-
	yl-ethoxy)-3H-benzoimidazol-5-yloxy]-propyl}-diethyl-amine
182	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(3-fluoro-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
183	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(3-diethylamino-
	propoxy)-1-isopropyl-1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
184	{3-[1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl)-6-(2-pyrrolidin-1-
	yl-ethoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
185	2-{4-[1-butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl-
	phenoxy}-benzoic acid methyl ester
186	{3-[2-[4-(biphenyl-4-yloxy)-phenyl]-1-butyl-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
187	{3-[2-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
188	{3-[1-butyl-2-[4-(4-chloro-benzylsulfanyl)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
189	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(3-diethylamino-
	propoxy)-3H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
190	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
191	[3-(1-butyl-6-(3-diethylamino-propoxy)-2-{4-(2-(4-fluoro-phenyl)-
	ethoxy]-phenyl}-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
192	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
193	{3-[2-[3-(4-tert-Butyl-phenoxy)-phenyl]-6-(3-diethylamino-propoxy)-
	1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
194	(3-{1-Butyl-6-(3-diethylamino-propoxy)-2-[4-(4-fluoro-3-trifluoromethyl-
	phenoxy)-2-trifluoromethyl-phenyl]-1H-benzoimidazol-4-yloxy}-
	propyl)-diethyl-amine
195	{3-[1-Butyl-2-[4-chloro-2-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-
	6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine
196	2-[3-(4-Chloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-
	benzoimidazole
197	1-Butyl-2-[3-(4-chloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
198	{3-[3-butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-7-(2-
	pyrrolidin-1-yl-ethoxy)-3H-benzimidazol-5-yloxy]-propyl}-diethyl-amine
199	{2-[1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-diisopropylamino-
	ethoxy)-1H-benzimidazol-4-yloxy]-ethyl}-diethyl-amine
200	{3-[2-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-1-butyl-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
201	{3-[2-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-1-butyl-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
202	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(4-methoxy-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
203	1-Butyl-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-4,6-bis-(2-
	pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
204	2-{4-[2-(4-Chloro-phenyl)-ethoxy]-phenyl}-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
205	1-Butyl-2-[4-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
206	1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-4,6-bis-(2-
	pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
207	{3-[1-Butyl-2-[4-(3-chloro-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
208	2-[5,7-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazol-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenol
209	2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(2-pyrrolodin-1-yl-ethoxy)-
	1H-benzimidazole
210	(3-{6-(3-Diethylamino-propoxy)-2-[2-(1,1-difluoro-ethyl)-4-(4-fluoro-3-
	trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-
	diethyl-amine
211	{3-[1-Butyl-2-[4-(4-tert-butyl-phenoxy)-phenyl]-6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
212	2-[4-(4-tert-Butyl-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzoimidazole
213	{3-[1-Butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-6-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
214	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-
	diethylaminomethyl-3H-benzimidazol-5-yloxy)-propyl]-diethyl-amine
215	(3-{6-(3-Diethylamino-propoxy)-2-[4-(4-fluoro-3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine
216	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(4-trifluoromethyl-
	pyrimidin-2-ylsulfanyl)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-
	diethyl-amine
217	{3-[6-(3-Diethylamino-propoxy)-2-(3-p-tolyloxy-phenyl)-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
218	4-{3-[1-Butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzoimidazol-2-
	yl]-phenoxy}-benzonitrite
219	[3-(3-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-7-pyrrolidin-1-yl-
	3H-benzoimidazol-5-yloxy)-propyl]-diethyl-amine
220	{3-[1-butyl-2-[4-(4-chloro-phenylmethanesulfinyl)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-
	amine
221	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(naphthalen-2-yloxy)-
	phenyl]-1H-benzoimidazole-4-yloxy}-propyl)-diethyl-amine
222	(3-{6-(3-diethylamino-propoxy)-2-[4-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
223	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[3-(4-methoxy-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
224	2-[3-(3,4-Dichloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzoimidazole
225	{3-[2-[4-(4-tert-Butyl-phenoxy)-phenyl]-6-(3-diethylamino-propoxy)-
	1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
226	{3-[3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-7-[2-(tetrahydro-
	furan-2-yl)-ethoxy]-3H-benzimidazol-5-yloxy}-propyl)-diethyl-amine
227	1-Butyl-2-[4-(3-chloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
228	[3-(7-Butoxy-3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3H-
	benzoimidazol-5-yloxy)-propyl]-diethyl-amine
229	4-{3-[4,6-Bis-(3-diethylamino-propoxy)-1H-benzoimidazol-2-yl]-
	phenoxy}-benzonitrile
230	2-[3-(3,5-Dichloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzoimidazole
231	{3-[1-butyl-2-(2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-ethyl)-6-(3-
	diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-
	amine
232	{3-[1-butyl-6-(3-diethylamino-propoxy)-2-(3-phenoxy-phenyl)-1H-
	benzimidazol-4-yloxy]-propyl}-diethyl-amine
233	{3-[1-Butyl-2-[2-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
234	2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-phenyl]-4,6-bis-(2-
	pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
235	{3-[1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-6-(2-
	pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
236	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-methyl-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
237	{3-[1-butyl-6-(3-diethylamino-propoxy)-2-(4-phenoxy-phenyl)-1H-
	benzimidazol-4-yloxy]-propyl}-diethyl-amine
238	5-[4,6-bis-(3-diethylamino-propoxy)-1H-benzoimidazlo-2-yl]-2-[2-(4-
	chloro-phenyl)-ethoxy]-phenol
239	[3-(6-Butoxy-1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-1H-
	benzoimidazol-4-yloxy)-propyl]-diethyl-amine
240	{3-[2-[4-Chloro-2-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
241	1-butyl-4-(4-chloro-benzyloxy)-2-{4-[2-(4-chloro-phenyl)-ethoxy]-
	phenyl}-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole
242	4-{4-[1-butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-
	phenoxy}-benzonitrile
243	[3-(1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-fluoro-1H-
	benzoimidazol-4-yloxy)-propyl]-diethyl-amine
244	(3-{6-(3-diethylamino-propoxy)-2-[3-(4-methoxy-phenoxy)-phenyl]-1H-
	benzimidazol-4-yloxy}-propyl)-diethyl-amine
245	(3-{6-(3-diethylamino-propoxy)-2-[4-(4-methoxy-phenoxy)-phenyl]-1H-
	benzimidazol-4-yloxy}-propyl)-diethyl-amine
246	{3-[1-butyl-2-[4-(4-chloro-3-fluoro-phenoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzimidazol-4-yl]-propyl}-diethyl-amine
247	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(quinolin-8-yloxy)-phenyl]-
	1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
248	{3-[2-[2-(4-chloro-3-trifluoromethyl-phenoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
249	2-[{2-[1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-
	morpholin-4-yl-ethoxy)-1H-benzoimidazol-4-yloxy]-ethyl}-(2-chloro-
	ethyl)-amino]-ethanol
250	(3-{6-(3-Diethylamino-propoxy)-2-[3-(4-fluoro-3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine
251	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-7-isopropoxy-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
252	[3-(1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-
	cyclopentylmethoxy-1H-benzoimidazol-4-yloxy)-propyl]-diethyl-amine
253	1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-4,6-bis-(2-
	morpholin-4-yl-ethoxy)-1H-benzoimidazole
254	{3-[2-[4-[2-(4-Chloro-phenyl)-ethoxy]-3-(3-diethylamino-propoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-
	propyl}-diethyl-amine

Example	Name
260	1-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolodin-1-yl-ethoxy)-
	phenyl]-6-(2-pyrrolodin-1-yl-ethoxy)-1H-benzoimidazole
261	{3-[2-{1-butyl-6-[2-(4-chloro-phenyl)-ethoxy]-1H-benzimidazol-2-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
262	2-{2,4-bis-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl}-1-butyl-6-(4-butyl-
	phenoxy)-1H-benzoimidazole
263	{3-[2-[1-butyl-5-(4-tert-butyl-phenoxy)-1H-benzimidazol-1-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
264	1-Butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
265	2-[2,4-bis-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1-butyl-6-(4-cyclopentyl-
	phenoxy)-1H-benzoimidazole
266	2-{2,4-bis-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl}-1-butyl-6-(4-
	cyclopentyl-phenoxy)-1H-benzoimidazole
267	{3-[2-[1-butyl-6-(4-iospropyl-phenoxy)-1H-benzimidazol-2-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
268	(2-{1-butyl-6-(2-dimethylamino-ethylsulfanyl)-2-[4-(4-fluoro-3-
	trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-
	benzoimidazol-4-ylsulfanyl}-ethyl)-dimethyl-amine
269	2-[2,4-bis-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1-butyl-6-(4-tert-butyl-
	phenoxy)-1H-benzimidazole
270	{3-[2-[1-butyl-6-(4-butyl-phenoxy)-1H-benzimidazol-2-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
271	{3-[2-[1-butyl-6-(4-fluoro-3-trifluoromethyl-phenoxy)-1H-benzimidazol-2-
	yl]-5-(3-diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
272	2-[2,4-bis-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1-butyl-6-(4-isopropyl-
	phenoxy)-1H-benzoimidazole
273	1-Butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-
	ethoxy)-1H-benzoimidazole
274	(3-{3-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-3H-benzoimidazol-5-yloxy}-propyl)-diethyl-amine
275	{3-[2-[1-butyl-6-(4-cyclopentyl-phenoxy)-1H-benzimidazol-2-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
276	{3-[2-[1-butyl-4-(4-tert-butyl-phenoxy)-1H-benzimidazol-2-yl]-5-(3-
	diethylamino-propoxy)-phenoxy]-propyl}-diethyl-amine
277	2-{2,4-bis-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-phenyl}-1-butyl-6-(4-
	isopropyl-phenoxy)-1H-benzoimidazole
278	(3-{5-[2-(4-chloro-phenyl)-ethoxy]-2-[6-(3-diethylamino-propoxy)-1-
	isopropyl-1H-benzimidazol-2-yl]-phenoxy}-propyl)-diethyl-amine
279	1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
280	1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-4,6-bis-(1-methyl-
	piperidin-4-yloxy)-1H-benzimidazole
281	{3-[2-[6-(4-tert-butyl-phenoxy)-1H-benzimidazol-2-yl]-5-(3-diethylamino-
	propoxy)-phenoxy]-propyl}-diethyl-amine
282	1-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-4,6-bis-(1-methyl-pyrrolidin-2-
	ylmethoxy)-1H-benzoimidazole
283	(3-{3-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-diethylamino-ethoxy)-
	phenyl]-3H-benzimidazol-5-yloxy}-propyl)-diethyl-amine
284	(3-{2-[1-Butyl-6-(2-imidazol-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine
285	(3-{2-[1-Butyl-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine
286	{3-[2-(3,5-bis-benzyloxy-phenyl)-3-butyl-3H-benzimidazol-5-yloxy]-
	propyl}-diethyl-amine
287	4,6-bis-(2-azepan-1-yl-ethoxy)-1-butyl-2-[3-(4-tert-butyl-phenoxy)-
	phenyl]-1H-benzoimidazole
288	1-butyl-2-[3-(4-butyl-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-
	1H-benzoimidazole
289	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(1-methyl-pyrrolidin-2-
	ylmethoxy)-1H-benzoimidazole
290	(2-{1-butyl-6-(2-dimethylamino-ethylsulfanyl)-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzoimidazole-4-ylsufanyl}-ethyl)-dimethyl-amine
291	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(4-isopropyl-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
292	4,6-bis-(2-azepan-1-yl-ethoxy)-1-butyl-2-[3-(3,5-dichlorophenoxy)-
	phenyl]-1H-benzoimidazole
293	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-[2-(cyclohexyl-methyl-
	amino)-ethoxy]-1H-benzoimidazole
294	{3-[1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-6-(2-imidazol-1-yl-ethoxy)-
	1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
295	[3-(2-{3,4-bis-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-3-butyl-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
296	1-butyl-4,6-bis-(1-methyl-piperidin-4-yloxy)-2-[3-(3-trifluoromethyl-
	phenoxy)-phenyl]-1H-benzoimidazole
297	4,6-bis-(2-azepan-1-yl-ethoxy)-1-butyl-2-[3-(3-trifluoromethyl-phenoxy)-
	phenyl]-1H-benzoimidazole
298	1-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-4,6-bis-(1-ethyl-pyrrolidin-2-
	ylmethoxy)-1H-benzoimidazole
299	[3-(2-{2-benzyloxy-4-[2-(4-chloro-phenyl)-ethoxy]-phenyl)-3-butyl-3H-
	benzimidazol-5-yloxy]-propyl}-diethyl-amine
300	{3-[2-[1-Butyl-6-(3-diethylamino-propoxy)-1H-benzoimidazol-2-yl]-5-(4-
	fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-propyl}-diethyl-amine
301	{3-[2-[1-Butyl-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazol-2-yl]-5-(4-
	fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-propyl}-diethyl-amine
302	1-butyl-2-[3-(3,4-dimethoxy-phenoxy)-phenyl]-4,6-bis-(2-pyrrolidin-1-yl
	ethoxy)-1H-benzimidazole
303	(2-{1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-(2-dimethylamino-
	ethylsulfanyl)-1H-benzoimidazol-4-ylsulfanyl}-ethyl)-dimethyl-amine
304	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(1-ethyl-pyrrolidin-3-
	yloxy)-1H-benzoimidazole
305	{3-[2-[3-(3,4-bis-benzyloxy-phenyl)-3-butyl-3H-benzimidazol-5-yloxy]-
	propyl}-diethyl-amine
306	(3-{5-[2-(4-chloro-phenyl)-ethoxy]-2-[6-(3-diethylamino-propoxy)-1H-
	benzimidazol-2-yl]-phenoxy}-propyl)-diethyl-amine
307	1-butyl-2-[4-(2-diethylamino-ethoxy)-phenyl]-4,6-bis-[2-(methyl-phenyl-
	amino)-ethoxy]-1H-benzimidazole
308	{3-[3-butyl-2-{4-[2-(4-chlorophenyl)-ethoxy]-phenyl}-7-(pyridin-3-yloxy)-
	3H-benzimidazol-5-yloxy]-propyl}-diethyl-amine
309	{2-[1-butyl-2-[3-(3,4-dichloro-phenoxy)-phenyl]-6-(2-diisopropylamino-
	ethoxy)-1H-benzimidazol-4-yloxy]-ethyl}-diethyl-amine
310	{3-[3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-7-(pyridin-3-
	ylmethoxy)-3H-benzimidazol-5-yloxy]-propyl}-diethyl-amine
311	2-[1-butyl-6-(3-diethylamino-propoxy)-1H-benzoimidazlo-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenol
312	{3-[3-butyl-2-[2-(4-chloro-phenylsulfanyl)-phenyl]-7-(3-diethylamino-
	propoxy)-3H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
313	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(4-fluoro-2-methoxy-
	phenoxy)-phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
314	[3-(3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-isopropoxy-phenyl}-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
315	{2-(1-butyl-6-(3-diethylamino-propoxy)-1H-benzoimidazlo-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenoxy}-acetic acid methyl ester
316	(3-{2-[1-butyl-6-(4-tert-butyl-phenoxy)-1H-benzimidazol-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine
317	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(2-isopropoxy-phenoxy)-
	phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine
318	(3-{1-butyl-6-(3-diethylamino-propoxy)-2-[4-(2,3-dimethoxy-phenoxy)-
	phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-amine
319	(3-{3-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-3H-benzoimidazol-5-yloxy}-propyl)-diethyl-amine
320	(2-{1-butyl-6-fluoro-2-[3-(3-trifluoromethyl-phenoxy)-phenyl]-1H-
	benzoimidazole-4-ylsufanyl}-ethyl)-dimethyl-amine
321	Methanesulfonic acid 5-[2-(4-chloro-phenyl)-ethoxy]-2-[6-(3-diethylamino-
	propoxy)-1H-benzoimidazol-2-yl]-phenyl ester
322	5-[2-(4-Chloro-phenyl)-ethoxy]-2-[6-(3-diethylamino-propoxy)-1H-
	benzoimidazol-2-yl]-phenol
323	{3-[1-butyl-6-(3-diethylamino-propoxy)-2-(4-pyrrolidin-1-yl-phenyl)-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
324	1-butyl-2-[3-(4-tert-butyl-phenoxy)-phenyl]-4,6-bis-(1-methyl-piperidin-4-
	yloxy)-1H-benzimidazole
325	1-butyl-2-[3-(3,5-dichloro-phenoxy)-phenyl]-4,6-bis-(2-imidazol-1-yl-
	ethoxy)-1H-benzoimidazole
326	[2-(1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-6-fluoro-1H-
	benzoimidazol-4-ylsulfanyl)-ethyl]-dimethyl-amine

Example	Name
339	{3-[1-butyl-2-[4-(3,4-dichloro-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-
	diethyl-amine
340	{3-[2-[2,4-bis-(3-diethylamino-propoxy)-phenyl]-1-butyl-6-(4-tert-butyl-
	phenoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
341	{3-[1-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(pyridin-2-ylmethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yl]-phenyl}-
	diethyl-amine
342	{3-[2-[4-[2-(4-Chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-
	6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
343	1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
344	{3-[1-Butyl-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-
	propyl}-diethyl-amine
345	(3-{6-(3-Diethylamino-propoxy)-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-
	2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-
	diethyl-amine
346	{3-[2-[1-Butyl-4-(3-diethylamino-propoxy)-6-(2-pyrrolidin-1-yl-ethoxy)-1H-
	benzoimidazol-2-yl]-5-(4-fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-
	propyl}-diethyl-amine
347	{3-[3-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-7-(2-pyrrolidin-1-yl-ethoxy)-3H-benzoimidazol-5-yloxy]-
	propyl}-diethyl-amine
348	{3-[1-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-6-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazol-4-yloxy]-propyl}-
	diethyl-amine
349	{3-[2-[1-butyl-4,6-bis-(2-pyrrolodin-1-yl-ethoxy)-1H-benzimidazol-2-yl]-5-
	(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-propyl}-diethyl-amine
350	{3-[1-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-3-diethylaminomethyl-
	phenyl}-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-
	diethyl-amine
351	{3-[2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(pyridin-2-ylmethoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzimidazol-4-yl]-propyl}-diethyl-amine
352	3-(7-Butoxy-3-butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-
	cyclopentylmethoxy-phenyl}-3H-benzoimidazol-5-yloxy)-propan-1-ol
353	3-(7-Butoxy-2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-cyclopentylmethoxy-
	phenyl}-3H-benzoimidazol-5-yloxy)-propan-1-ol
354	(3-{1-Butyl-6-(3-diethylamino-propoxy)-2-[4-(4-fluoro-3-trifluoromethyl-
	phenoxy)-2-(pyridin-2-ylmethoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-
	propyl)-diethyl-amine
355	{3-[2-[1-Butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzoimidazol-2-yl]-5-
	(4-fluoro-3-trifluoromethyl-phenoxy)-phenoxy]-propyl}-diethyl-amine
356	2-(3,5-bis-benzyloxy-phenyl)-1-butyl-4,6-bis-(2-pyrrolodin-1-yl-ethoxy)-
	1H-benzimidazole
357	{3-[2-[1-butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-5-
	(4-fluoro-3-trifluoromethyl-phenoxy)-phenyl]-propyl}-diethyl-amine
358	1-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrol-1-yl-ethoxy)-phenyl]-
	4,6-bis-(2-pyrrolodin-1-yl-ethoxy)-1H-benzoimidazole
359	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-(3-diethylamino-propoxy)-phenyl}-
	6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-
	amine
360	{3-[1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(pyridin-3-ylmethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine
361	(3-{3-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(3-diethylamino-propoxy)-
	phenyl]-7-isopropoxy-3H-benzoimidazol-5-yloxy}-propyl)-diethyl-amine
362	{3-[1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(pyridin-4-ylmethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine
363	{3-[2-[4-[2-(4-Chloro-phenyl)-ethoxy]-2-(pyridin-4-ylmethoxy)-phenyl]-6-
	(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-
	amine
364	1-Butyl-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(pyridin-2-ylmethoxy)-
	phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
365	2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,7-
	bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzimidazole
366	{3-[1-Butyl-2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-methoxy-phenyl}-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
367	{3-[2-{4-[2-(4-Chloro-phenyl)-ethoxy]-2-methoxy-phenyl}-6-(3-
	diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-diethyl-amine
368	(3-{1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(3-diethylamino-propoxy)-
	phenyl]-6-isopropoxy-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine
369	{3-[1-Butyl-2-[4-(4-chloro-3-methyl-phenoxy)-2-(pyridin-2-ylmethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine
370	1-Butyl-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-2-cyclopentylmethoxy-
	phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
371	(2-{1-butyl-6-(2-dimethylamino-ethoxy)-2-[4-(4-fluoro-3-trifluoromethyl-
	phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazole-4-
	yloxy}-ethyl)-dimethyl-amine
372	2-[1-butyl-4,6-bis-(3-diethylamino-propoxy)-1H-benzimidazol-2-yl]-5-[2-(4-
	chloro-phenyl)-ethoxy]-phenol
373	1-Butyl-2-[4-(4-chloro-3-methyl-phenoxy)-2-(pyridin-2-ylmethoxy)-phenyl]-
	4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
374	2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-2-cyclopentylmethoxy-phenyl]-
	4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
375	2-[4-(4-Fluoro-3-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-4,6-bis-(2-pyrrolidin-1-yl-ethoxy)-1H-benzoimidazole
376	{3-[2-(3,5-bis-benzyloxy-phenyl)-1-butyl-6-(3-diethylamino-propoxy)-1H-
	benzimidazol-4-yloxy]-propyl}-diethyl-amine
377	(3-{1-butyl-6-(3-dimethylamino-propoxy)-2-[4-(3-fluoro-phenoxy)-2-(2-
	pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazole-4-yloxy}-propyl)-
	diethyl-amine
378	{3-[2-{1-butyl-4-(4-chloro-benzyloxy)-6-(2-pyrrolidin-1-yl-ethoxy)-1H-
	benzimidazol-2-yl]-5-[2-(4-chloro-phenyl)-ethoxy]-phenoxy}-propyl)-
	diethyl-amine
379	{3-[2-{4-[2-(4-chloro-phenyl)-ethoxy]-2-(3-diethylamino-propoxy)-phenyl]-
	6-(3-diethylamino-propoxy)-3H-benzimidazol-4-yloxy]-propyl}-diethyl-
	amine
380	{3-[2-[4-(3,4-dichloro-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-6-(3-
	diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-diethyl-amine
381	{3-[1-Butyl-2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-2-
	cyclopentylmethoxy-phenyl]-6-(3-diethylamino-propoxy)-1H-
	benzoimidazol-4-yloxy]-propyl}-diethyl-amine
382	{3-[2-[4-(4-chloro-3-trifluoromethyl-phenoxy)-2-cyclopentylmethoxy-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine
383	(3-{1-butyl-6-(4-tert-butyl-phenoxy)-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(3-
	diethylamino-propoxy)-phenyl]-1H-benzimidazol-4-yloxy}-propyl)-diethyl-
	amine
384	2-{2,4-bis-[2-(4-chloro-phenyl)-ethoxy]-phenyl}-1-butyl-4,6-bis-(2-
	pyrrolidin-1-yl-ethoxy)-1H-benzimidazole
385	(2-{1-butyl-6-(2-dimethylamino-ethoxy)-2-[4-(3-fluoro-phenoxy)-2-(2-
	pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazole-4-yloxy}-ethyl)-
	dimethyl-amine
386	{3-[2-[4-(3,5-bis-trifluoromethyl-phenoxy)-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-1-butyl-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-
	propyl}-diethyl-amine
387	{3-[1-butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-2-(2-pyrrolidin-1-yl-ethoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-
	diethyl-amine
388	(3-{2-(1-Butyl-4,6-diisopropoxy-1H-benzoimidazol-2-yl)-5-[2-(4-chloro-
	phenyl)-ethoxy]-phenoxy}-propyl)-diethyl-amine
389	{3-[1-butyl-2-{3-[2-(4-chloro-phenyl)-ethoxy]-4-diethylaminomethyl-
	phenyl}-6-(3-diethylamino-propoxy)-1H-benzimidazol-4-yloxy]-propyl}-
	diethyl-amine
390	(3-{1-Butyl-6-(3-diethylamino-propoxy)-2-[4-fluoro-2-(2-pyrrolidin-1-yl-
	ethoxy)-phenyl]-1H-benzoimidazol-4-yloxy}-propyl)-diethyl-amine
391	(2-{1-butyl-6-fluoro-2-[4-(4-fluoro-3-trifluoromethyl-phenoxy)-2-(2-
	pyrrolidin-1-yl-ethoxy)-phenyl]-1H-benzoimidazol-4-ylsulfanyl}-ethyl)-
	dimethyl-amine
392	{3-[1-Butyl-2-[4-[2-(4-chloro-phenyl)-ethoxy]-3-(3-diethylamino-propoxy)-
	phenyl]-6-(3-diethylamino-propoxy)-1H-benzoimidazol-4-yloxy]-propyl}-
	diethyl-amine

Example	Name
398	(3-{2-[(4-benzyloxy-benzylamino)-methyl]-3-butyl-3H-
	benzimidazol-5-yloxy}-propyl)-diethyl-amine
399	N-(4-benzyloxy-benzyl)-N-[1-butyl-6-(3-diethylamino-
	propoxy)-1H-benzimidazol-2-ylmethyl]-methanesulfonamide
400	N-(4-benzyloxy-benzyl)-N-[1-butyl-6-(3-diethylamino-
	propoxy)-1H-benzimidazol-2-ylmethyl]-acetamide
401	{3-[3-butyl-2-({4-[2-(4-chloro-phenyl)-ethoxy]-
	benzylamino}-methyl)-3H-
	benzimidazol-5-yloxy)-propyl]-diethyl-amine
402	[3-(2-{[Bis-(4-benzyloxy-benzyl)-amino]-methyl}-3-butyl-3H-
	benzoimidazol-5-yloxy)-propyl]-diethyl-amine
403	[3-(2-{[Benzyl-(4-benzyloxy-benzyl)-amino]-methyl}-3-butyl-
	3H-benzoimidazol-5-yloxy)-propyl]-diethyl-amine

Pharmacologic classifications of treatment for Alzheimer's Disease

1. Cholinesterase Inhibitor:	Tacrine, Donepezil
2. Antipsychotics:	Haloperidol, Thioridazine
3. Antidepressants:	Desipramine, Fluoxetine,
	Trazodone, Paroxetine
4. Anticonvulsants:	Carbamazepine, Valproic acid

description truncated at 500,000 characters

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Claims as granted

4 claims

Classifications

43 codes

IPC · International Patent Classification

Section A — Human necessities

A61P43/00
A61K9/12
A61P11/06
A61P13/12
A61K31/4725
A61K31/4178
A61P9/10
A61P27/02
A61K31/4184
A61P3/10
A61P35/00
A61K31/4439
A61K31/496
A61P29/00
A61K31/4164
A61P25/28
A61P15/10
A61K31/42
A61P11/00
A61K31/454
A61K45/00
A01N43/50

Section C — Chemistry; metallurgy

C07D233/64
C07D401/06
C07D413/12
C07D403/12
C07D405/12
C07D235/18
C07D233/54
C07D235/08
C07D233/61
C07D453/02
C07D403/14
C07D235/14
C07D235/30
C07D235/10
C07D401/04
C07D401/14
C07D401/12
C07D405/04
C07D235/12

USPC · US Patent Classification

548/340.1514/400

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Rebecca L Anderson

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