Substituted 1,2,3-triazolopyrimidines for the inhibition of NAD(P)H oxidases and platelet activation

The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and inhibition of platelet activation. In particular, the invention relates to 1,2,3-triazolo[4,5-d]pyrimidine compounds, wherein a N-heteroaryl moiety is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to the triazolopyrimidinyl moiety. The invention also relates to a process for the preparation of said compounds.

NAD(P)H oxidases (NOX) are multi-subunit enzymes that generate superoxide and other reactive oxygen species (ROS) from oxygen. NAD(P)H oxidases consist of a membrane associated catalytic moiety, the NAD(P)H oxidase homologues, which contain all prosthetic groups needed to transfer electrons from NADPH to oxygen, whereby superoxide is produced. Despite the importance of ROS in the regulation of fundamental physiological processes, ROS production can also cause oxidative stress, which is an important causal factor in the origin and progression of chronic, degenerative diseases such as those of the cardiovascular system. While moderate, physiological concentrations of ROS are regulatory molecules, their production can lead to a variety of defects and miss-regulation if its timing and magnitude is not fine-tuned. An important consequence of the formation of ROS in vascular cells is the consumption of nitric oxide (NO). NO inhibits the development of vascular diseases, and loss of NO is important in the pathogenesis of cardiovascular diseases.

Thus, ROS derived from NAD(P)H oxidases contribute to the pathogenesis of numerous diseases, especially cardiovascular diseases or disorders associated with endothelial dysfunction including but not limited to hypertension, atherosclerosis, cardiac hypertrophy, heart failure, restenosis, diabetes and angina pectoris. Other diseases and disorders associated with an increased NAD(P)H oxidase activity are among others various chronic inflammatory diseases, neuro-degenerative diseases including Alzheimer's disease, bronchial asthma, reperfusion injuries, kidney diseases, cancer, arthritis and pulmonary hypertension. In these and other pathological conditions, the NAD(P)H oxidases are a predominant source of ROS, and activation of these enzymes leads to a variety of intracellular signaling events that ultimately cause dysfunction of the endothelium, proliferation of cells, expression of pro-inflammatory genes and reconstruction of the extracellular matrix.

WO 04/005267 A1 discloses substituted heteroaryl and heterocyclic compounds, which are useful in treating or ameliorating a reactive oxygen species (ROS) mediated disease. Said compounds are based on substituted five-membered rings of the heteroazol type.

WO 01/36421 discloses 1,2,3-triazolo[4,5-d]pyrimidine compounds, which are substituted at C-7 with amino groups. Said compounds can act as inhibitors of platelet activation, which is induced by ADP (adenosine 5′-diphosphate). Said compounds have antithrombotic activity.

Further 1,2,3-triazolo[4,5-d]pyrimidine compounds are disclosed in the following documents:

EP 0 201 289 discloses 5-amino-7-halo-1,2,3-triazolo[4,5-d]pyrimidine derivatives with antiviral activity.

JP 59062594 and JP 59062595 disclose 3-phenyl-1,2,3-triazolo[4,5-d]pyrimidine derivatives, which are substituted at C-5 and C-7 with halogen, alkoxy, alkylthio, amino, and which have antitumor activity.

JP 56131586 and JP 56131587 disclose 5H-3-phenyl-1,2,3-triazolo[4,5-d]pyrimidine derivatives, which are substituted at C-7 with cyano, tosyl, alkoxy, phenoxy, hydrazino and the like, which have antitumor activity.

3-[(4-chlorophenyl)methyl]-7-[4-(2-propenyl)-5-(4-pyridinyl)-1,2,4-triazol-3-yl]thio]-1,2,3-triazolo[4,5-d]pyrimidine (Caplus registry number 499140-86-2), 3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine-3-[(4-fluorophenyl)methyl]-N-2-pyridinyl-(9CI) (Caplus registry number 255370-07-1) and 3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine-3-[(2-fluorophenyl)methyl]-N2-pyridinyl-(9CI) (Caplus registry number 255369-94-9) are already known.

It was the object of the invention to develop new active agents, which focus on the NO signal cascade and it's counterpart NAD(P)H oxidases (NOX), because NOX inhibitors might have substantial clinical potential for the prevention and treatment of a broad range of diseases and disorders.

This object could be achieved with compounds of the general Formula (I):

het -(CH 2 ) n —X-AB  (I)

where

het is five-membered or six-membered N-heteroaryl or fused five-membered or six-membered N-heteroaryl;

n is an integer and is 0 or 1;

X is O, S, NR 7 and R 7 is selected from R 3 ;

and where the N-atom of the N-heteroaryl moiety and the —(CH 2 ) n —X group are separated by one carbon atom;

AB is a 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical of the general Formula (II):

where R 3 is hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cyclo-alkenyl; alkynyl; alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, alkynyl containing one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I)

R 5 is hydrogen; halogen (F, Cl, Br, I); OH; R 3 —S; R 3 —O; NR 1 R 2 , where R 1 and R 2 are independently from each other R 3 , or where R 1 and R 2 form together a ring system; het-(CH 2 ) n —X, where het, n and X have the meaning as defined above;

or a pharmaceutically acceptable salt or solvate thereof, or a solvate of such a salt;

with the proviso that 3-[(4-chlorophenyl)methyl]-7-[4-(2-propenyl)-5-(4-pyridinyl)-1,2,4-triazol-3-yl]thio]-1,2,3-triazolo[4,5-d]pyrimidine (Caplus registry number 499140-86-2), 3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine-3-[(4-fluorophenyl)methyl]-N2-pyridinyl-(9CI) (Caplus registry number 255370-07-1) and 3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine-3-[(2-fluorophenyl)methyl]-N-2-pyridinyl-(9CI) (Caplus registry number 255369-94-9) are excluded.

The term “N-heteroaryl” refers to an aromatic five- or six-membered carbocyclic ring system, wherein at least one carbon atom is substituted by a nitrogen atom. Said term also refers to possible tautomeric forms of said ring system. For example, the 2-hydroxy-pyrimidine system can be written in the form of the tautomeric 1H-2-oxo system.

Said nitrogen atom of the N-heteroaryl moiety and the —(CH 2 ) n —X group are separated by one carbon atom, what means that the N-heteroaryl moiety is substituted with said group vicinally to said nitrogen atom.

In other embodiments, it is possible to replace further carbon atoms in said N-heteroaryl moiety by further heteroatoms, preferably by nitrogen, oxygen or sulfur atoms.

Preferably, the five-membered N-heteroaryl is imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, oxdiazolyl, thiadiazolyl, tetrazolyl, oxtriazolyl, thiatriazolyl, which may be substituted with hydrogen and/or with other substituents, preferably those, which are defined below.

In particular preferred are imidazolyl, oxazolyl, thiazolyl.

Preferably, the six-membered N-heteroaryl is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, which may be substituted with hydrogen and/or with other substituents, preferably those, which are defined below.

In particular preferred is pyridinyl, pyrimidinyl.

Furthermore, the N-heteroaryl moiety can be fused with an alicyclic, aromatic or heteroaromatic system, wherein the resulting system may be substituted with hydrogen and/or with other substituents, preferably those, which are defined below.

In one embodiment, the five-membered N-heteroaryl is fused with an aromatic system.

Preferably, said aromatic system is the benzo system. Resulting five-membered N-heteroaryl systems include benzimidazolyl, benzoxazolyl, benzthiazolyl.

Heteroaromatic systems, with which five-membered N-heteroaryl can be fused, are for example, pyridine, quinoline, benzothiazole.

If, for example, the 1,2,4,-trizaole is fused with pyridine, quinoline, benzothiazole, for example, the fused radicals 1,2,4-triazolo[4,3-a]pyridine-3-yl, 1,2,4-triazolo[4,3-a]quinolin-3-yl and 1,2,4-triazolo[4,3-a]benzothiazol-3-yl can result.

In another embodiment, the six-membered N-heteroaryl is fused with an aromatic system.

Preferably, said aromatic system is the benzo system. Resulting six-membered N-heteroaryl systems include quinolinyl and isoquinolinyl.

Other aromatic systems, with which five- and six membered N-heteroaryl can be fused, include the pyridine and pyrimidine system.

Another aspect of the invention relates to a compound of the general Formula (I), wherein one or more hydrogen atoms of the five-membered or six-membered N-heteroaryl moiety or fused five-membered or six-membered N-heteroaryl moiety can be substituted independently from each other by one or more R 3 radicals.

The term “alkyl” refers to a saturated straight or branched carbon chain. Preferably, the chain comprises from 1 to 8 carbon atoms.

The term “cycloalkyl” refers to a saturated monocyclic or bicyclic ring. Preferably, the monocyclic ring system consists of from 3 to 8 carbon atom and the bicyclic ring system of from 9 to 10 carbon atoms. In particular, preferred is a monocyclic ring with from 3 to 6 carbon atoms. Examples are cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

The term “aryl” preferably refers to an aromatic monocyclic ring containing 6 carbon atoms, an aromatic bicyclic ring system containing 10 carbon atoms or an aromatic tricyclic ring system containing 14 carbon atoms. Examples are phenyl, naphthalenyl or anthracenyl.

The term “aralkyl” refers to an alkyl moiety, which is substituted by aryl, wherein alkyl and aryl have the meaning as outlined above. An example is the benzyl radical.

The terms “alkenyl” and “cycloalkenyl” refer to olefinic unsaturated carbon atoms containing chains or rings with one or more double bonds. Examples are propenyl and cyclohexenyl.

The term “alkynyl” refers to unsaturated carbon atoms containing chains or rings with one or more triple bonds. An example is the propargyl radical.

In one embodiment, carbon atoms or hydrogen atoms in alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, alkynyl radicals can be substituted independently from each other with one or more elements selected from the group consisting of O, S, N or with groups containing one or more elements selected from the group consisting of O, S, N.

Embodiments include alkoxy, cycloalkoxy, aryloxy, aralkoxy, alkenyloxy, cycloalkenyloxy, alkynyloxy, alkylthio, cycloalkylthio, arylthio, aralkylthio, alkenylthio, cycloalkenylthio, alkynylthio, alkylamino, cycloalkylamino, arylamino, aralkylamino, alkenylamino, cycloalkenylamino, alkynylamino radicals.

Other embodiments include hydroxyalkyl, hydroxycycloalkyl, hydroxyaryl, hydroxyaralkyl, hydroxyalkenyl, hydroxycycloalkenyl, hydroxyalkynyl, mercaptoalkyl, mercaptocycloalkyl, mercaptoaryl, mercaptoaralkyl, mercaptoalkenyl, mercaptocycloalkenyl, mercaptoalkynyl, aminoalkyl, aminocycloalkyl, aminoaryl, aminoaralkyl, aminoalkenyl, aminocycloalkenyl, aminoalkynyl radicals.

In one embodiment, wherein one or more carbon atom of a carbocyclic system is/are substituted by one or more heteroatoms, a heterocyclyl radical results. The term “heterocyclyl” preferably refers to a saturated or partially unsaturated ring having five members of which at least one member is a N, O or S atom and which optionally contains one additional 0 or one additional N; a saturated or partially unsaturated ring having six members of which at least one member is a N, O or S atom and which optionally contains one additional 0 or one additional N or two additional N atoms; or, a saturated or partially unsaturated bicyclic ring having nine or ten members of which at least one member is a N, O or S atom and which optionally contains one, two or three additional N atoms. Heterocyclyl groups are optionally substituted. Examples include, and are not limited to, pyrrolinyl, pyrrolidinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, piperidinyl, morpholinyl or piperazinyl.

In another embodiment, hydrogen atoms in alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, alkynyl radicals can be substituted independently from each other with one or more halogen atoms. One radical is the trifluoromethyl radical.

If two or more radicals can be selected independently from each other, then the term “independently” means that the radicals may be the same or may be different.

Aspects of the present invention include compounds of the general Formula (I) wherein R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Other aspects of the invention include compounds of the Formula (I) wherein substituents of het of the het-(CH 2 ) n —X moiety are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Further aspects of the invention include compounds of the general Formula (I), wherein n is 0 and X is O, S or NR 7 .

Further aspects of the invention include compounds of the general Formula (I), wherein n is 1 and X is O, S or NR 7 .

Preferred embodiments of the invention include compounds of the general Formula (I), wherein n is 0 or 1 and X is S.

Other preferred embodiment of the invention include compounds of the general Formula (I), wherein n is 1 and X is O or NR 7 .

Another aspect of the invention includes compounds of the general Formula (I) wherein R 3 is a benzyl radical, which can be substituted. Preferably R 3 is CH 2 -phenyl-R 4 and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Still further aspects of the invention include compounds of the general Formula (I) wherein R 5 is selected from hydrogen, NH 2 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, benzyl, phenyl, preferably from hydrogen, NH 2 , (C 1-8 )alkyl, benzyl, phenyl.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-8 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (CO 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-5 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )allyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-5 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-8 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 13 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH— (heteroaryl-R 4 ), —NH— (heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-5 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )allyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )allyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted five-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is imidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isothiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-5 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted triazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxdiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-8 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiadiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted tetrazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1 —S)alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted oxtriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted thiatriazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (Co 8)alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (Co 8)alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 3-6 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH— ((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused five-membered N-heteroaryl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-3 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —P, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 11 g)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted pyridazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,3-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1- )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,2,4-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted 1,3,5-triazinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1 -s)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents of het, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted fused six-membered N-heteroaryl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-8 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted quinolinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

One aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-5 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another aspect of the invention includes compounds of the Formula (I), wherein het is substituted isoquinolinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 3 and R 5 are independently selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1 -g)alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 , C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1 -s)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 57 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 0; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1 -g)alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —N—H—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-8 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1 -g)alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 11 g)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1 -g)alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is S; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S-(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 11 g)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted imidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted oxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 9 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzthiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-5 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R), (C 1 g)alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzimidazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted benzoxazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1 -g)alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-8 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyridinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S-(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is (C 1-8 )alkyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is benzyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted pyrimidinyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is O; and R 5 is phenyl; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

A preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 5 is H; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen)-3, —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and R 1 and R 2 are independently selected from H, (C 1 -C 8 )alkyl, (C 3 -C 6 )cycloalkyl, phenyl, aryl, or where R 1 and R 2 form together a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, wherein at least one carbon atom can be replaced by O, S or N.

Another preferred embodiment of the invention includes compounds of the Formula (I), wherein het is substituted thiazolyl, wherein substituents of het are selected independently from each other from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8 )alkoxy, —O-phenyl, —O-aryl, —O-heteroaryl, —NR 1 R 2 , —CONR 1 R 2 , —S—(C 1-5 )alkyl, —S(O) 2 —(C 1-5 )alkyl, —S(O) 2 —NR 1 R 2 , —O—CO—(C 1-5 )alkyl, —O—CO-aryl, —CO—O—(C 1-5 )alkyl, —CO—O-aryl; and n is 1; and X is NR 7 and R 7 is selected from R 3 ; and R 5 is NH 2 ; and R 3 is selected from (C 0-8 )alkylene-R 6 , where R 6 is selected from hydrogen, (C 1-8 )alkoxy, —OH, (halogen) 1-3 , —NR 1 R 2 , —NH—((C 1-8 )alkyl-R 4 ), —NH—(aryl-R 4 ), —NH—(heteroaryl-R 4 ), —NH—(heterocyclyl-R 4 ), —NH—((C 3-6 )cycloalkyl-R 4 ), —S—((C 1-8 )alkyl-R 4 ), —S—(aryl-R 4 ), —S—(heteroaryl-R 4 ), —S—(heterocyclyl-R 4 ), —S—((C 3-6 )cycloalkyl-R 4 ), (C 1-8 )alkyl-R 4 , (C 3-6 )cycloalkyl-R 4 , heterocyclyl-R 4 , phenyl-R 4 , aryl-R 4 , heteroaryl-R 4 , and R 4 is from 1 to 3 substituents independently selected from hydrogen, —F, —Cl, —OH, —CN, —NO 2 , —CF 3 , (C 1-8 )alkyl, (C 3-6 )cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C 1-8