LexDanaLexDanabeta
Inventor

James McSwiggen

Inventor
Boulder, CO, US

Overview

112→
Patents
1996–2021
Patent span
Chemistry
Primary field (CPC C)

Patents· 112 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

C12Nprimary
C12NMicroorganisms or enzymes31%
A61KPreparations for medical, dental or toiletry purposes22%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations16%
C07HSugars14%
C12YEnzymes7%
C07KPeptides6%
C12QMeasuring or testing processes involving enzymes, nucleic acids or microorganisms2%
Y02ATechnologies for adaptation to climate change1%
C07FAcyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium1%
Y10TTechnical subjects covered by former us classification0%
PatentTitleYear
10,889,815RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)202110,837,014Compositions and methods for modulating SMN gene family expression202010,662,428RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)202010,655,128Compositions and methods for modulating MECP2 expression202010,351,852RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)201910,174,315Compositions and methods for modulating hemoglobin gene family expression201910,174,323Compositions and methods for modulating ATP2A2 expression201910,059,941Compositions and methods for modulating SMN gene family expression201810,058,623Compositions and methods for modulating UTRN expression201810,000,754RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)20189,957,517RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)20189,771,588'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20179,738,899'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20179,732,344'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20179,657,294'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20179,181,551'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20159,074,205'Nicked or gapped nucleic acid molecules and uses thereof'20158,846,894'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20148,618,277'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20138,614,309'Double-stranded RNA directed to CASP2 and methods of use thereof'20138,273,866'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)'20128,268,986'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20128,258,288'RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)'20128,242,257'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20128,236,944'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20128,232,383'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20128,202,979'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid'20128,153,778'RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)'20128,076,472'RNA interference mediated inhibition of muscarinic colinergic receptor gene expression using short interfering nucleic acid (siNA)'20118,067,575'RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)'20118,017,761'RNA interference mediated inhibition of Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucelic acid (siNA)'20118,017,765'RNA interference mediated treatment of alzheimer\'s disease using short interfering nucleic acid (siNA)'20118,013,146'RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)'20118,013,143'RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)'20118,008,473'RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)'20118,008,472'RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)'20117,989,612'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20117,985,853'RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)'20117,977,472'RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)'20117,956,178'RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)'20117,956,176'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20117,943,757'RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)'20117,935,812'RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)'20117,928,220'RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)'20117,928,219'RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)'20117,928,218'RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)'20117,923,549'RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)'20117,923,547'RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)'20117,915,400'RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)'20117,910,725'RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)'20117,910,724'RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)'20117,897,752'RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)'20117,897,753'RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)'20117,897,755'RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)'20117,897,757'RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)'20117,897,756'RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)'20117,893,248'RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)'20117,858,771'RNA interference mediated inhibition of muscarinic colinergic receptor gene expression using short interfering nucleic acid (siNA)'20107,855,284'RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)'20107,795,422'RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)'20107,700,760'RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)'20107,691,999'RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)'20107,683,166'RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)'20107,683,165'RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)'20107,678,897'RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)'20107,667,029'RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)'20107,667,030'RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)'20107,662,952'RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)'20107,662,951'RNA interference mediated treatment of Alzheimer\'s disease using short interfering nucleic acid (siNA)'20107,659,390'RNA interference mediated inhibition of muscarinic colinergic receptor gene expression using short interfering nucleic acid (siNA)'20107,659,389'RNA interference mediated inhibition of MYC and/or MYB gene expression using short interfering nucleic acid (siNA)'20107,521,184'Detection and quantitation of nucleic acid molecules in biological samples'20097,176,304'RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)'20077,034,009'Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)'20067,022,828'siRNA treatment of diseases or conditions related to levels of IKK-gamma'20066,818,447'Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor'20046,673,611'Nucleic acid molecules with novel chemical compositions capable of modulating gene expression'20046,623,962'Enzymatic nucleic acid treatment of diseases of conditions related to levels of epidermal growth factor receptors'20036,566,127'Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor'20036,528,639'Base-modified enzymatic nucleic acid'20036,436,644'Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1)'20026,410,224'Ribozyme treatment of diseases or conditions related to levels of NF-B'20026,350,934'Nucleic acid encoding delta-9 desaturase'20026,346,398'Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor'20026,194,150'Nucleic acid based inhibition of CD40'20016,159,692'Method and reagent for inhibiting human immunodeficiency virus replication'20006,132,967'Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (ICAM-1)'20006,103,890'Enzymatic nucleic acids that cleave C-fos'20006,057,156'Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors'20006,022,962'Hairpin ribozymes'20005,972,704'HIV nef targeted ribozymes'19995,891,684'Base-modified enzymatic nucleic acid'19995,879,938'Base-modified enzymatic nucleic acid'19995,877,021'B7-1 targeted ribozymes'19995,877,022'Ribozymes targeted to APO(a) RNA'19995,837,855'Hairpin ribozymes'19985,837,542'Intercellular adhesion molecule-1 (ICAM-1) ribozymes'19985,817,796'C-myb ribozymes having 2\'-5\'-linked adenylate residues'19985,811,300'TNF-.alpha. ribozymes'19985,807,743'Interleukin-2 receptor gamma-chain ribozymes'19985,767,263'Base-modified enzymatic nucleic acid'19985,731,295'Method of reducing stromelysin RNA via ribozymes'19985,705,388'CETP Ribozymes'19985,693,532'Respiratory syncytial virus ribozymes'19975,693,535'HIV targeted ribozymes'19975,658,780'Rel a targeted ribozymes'19975,646,042'C-myb targeted ribozymes'19975,631,359'Hairpin ribozymes'19975,616,488'IL-5 targeted ribozymes'19975,612,215'Stromelysin targeted ribozymes'19975,599,706'Ribozymes targeted to apo(a) mRNA'19975,525,468'Assay for Ribozyme target site'1996

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1996–2003Patents assigned to RIBOZYME PHARM INC (30)· patent assignee history
1996Based in Solon, OH, US· patent location history
1997–2014Based in Boulder, CO, US· patent location history
2003–2021Patents assigned to SIRNA THERAPEUTICS INC (40)· patent assignee history
2007–2015Patents assigned to MCSWIGGEN JAMES (19)· patent assignee history
2007–2014Patents assigned to BEIGELMAN LEONID (18)· patent assignee history
2010–2013Patents assigned to MERCK SHARP & DOHME (23)· patent assignee history
2010–2015Based in Bothell, WA, US· patent location history
2015–2021Based in Arlington, MA, US· patent location history

Inventor activity

Assignee and location history derived from the patent record.

Assignees
AssigneePatentsSpan
SIRNA THERAPEUTICS INC402003–2021
RIBOZYME PHARM INC301996–2003
MERCK SHARP & DOHME232010–2013
MCSWIGGEN JAMESself192007–2015
BEIGELMAN LEONID182007–2014
Locations
LocationPatentsSpan
Boulder, CO, US791997–2014
Arlington, Massachusetts, US162015–2021
Bothell, Washington, US162010–2015
Solon, OH, US11996