Inventor
Heinz-Werner Kleemann
Inventor
Bischofsheim, DE
Overview
Patents· 104 as inventor
Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.
A61Pprimary
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations36%
C07CAcyclic or carbocyclic compounds25%
C07DHeterocyclic compounds24%
A61KPreparations for medical, dental or toiletry purposes9%
A01NPreservation of bodies of humans or animals or plants or parts thereof2%
C07BGeneral methods of organic chemistry1%
G01NInvestigating or analysing materials by determining their chemical or physical properties1%
C07JSteroids1%
A61BDiagnosis0%
C07KPeptides0%
PatentTitleYear
9,718,825'N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals'20179,018,383'Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals'20158,618,304'Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals'20138,541,449'Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors'20138,455,469'Use of norgestimate as a selective inhibitor of TRPC3, TRPC6 and TRPC7 ion channels'20138,404,893'Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them'20138,399,482'6-substituted isoquinolines and isoquinolinones'20138,304,438'Heteroarylacrylamides and their use as pharmaceuticals'20128,283,374'Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives'20128,188,291'Heteroaryl-substituted carboxamides and their use as pharmaceuticals'20128,076,324'Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them'20118,008,352'Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them'20117,932,416'Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates'20117,772,262'Substituted benzoylguanidines, method for production and use thereof as medicament or diagnostic and medicament comprising the same'20107,763,661'Ortho-substituted pentafluorosulfanyl benzenes, method for the production thereof and their use as synthesis intermediates'20107,659,429'Process for preparing 4-pentafluorosulfanylbenzoylguanidines'20107,638,521'3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them'20097,622,611'Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same'20097,589,117'Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them'20097,531,663'3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them'20097,531,569'Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives'20097,449,594'Process for preparing 4-pentafluorosulfanylbenzoylguanidines'20087,381,841'Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them'20087,375,138'Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them'20087,332,608'Anthranilamides and methods of their use'20087,317,124'Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates'20087,235,664'Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use'20077,235,690'Anthranilamides and methods of their use'20077,230,007'Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom'20077,126,026'Process for preparing 4-pentafluorosulfanylbenzoylguanidines'20067,078,428'Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them'20067,078,414'Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them'20066,982,279'Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them'20066,924,392'Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them'20056,903,216'Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use'20056,878,748'Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them'20056,825,231'Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them'20046,794,377'Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them'20046,730,697'Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid'20046,703,411'Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'20046,632,840'Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them'20036,617,344'Heterocyclically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them'20036,605,625'Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them'20036,602,866'Mercaptoacetylamide derivatives, a process for their preparation and their use'20036,593,352'Substituted anthranilic acids, their use as a medicament or diagnostic, and medicament comprising them, and a pharmaceutical combination preparation containing a sodium/hydrogen exchange (NHE) blocker'20036,573,288'Substituted sulphonyl cyanamides, method for producing same and their use as medicament'20036,504,057'Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'20036,486,189'Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them'20026,451,781'Substituted acylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them'20026,436,999'Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them'20026,372,917'Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them'20026,369,069'Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament'20026,369,236'Imidazole derivatives with biphenylsulfonyl substitution method for preparing them and their use as a drug or diagnostic agent'20026,339,077'Substituted 4-benzylaminoquinolines and their hetero analogs, process for their preparation, pharmaceuticals containing these compounds and use thereof'20026,335,451'Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them'20026,262,123'Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them'20016,156,800'4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'20006,153,651'Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them'20006,093,729'Substituted bicyclic heteroaroylguanidines, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them'20006,087,304'Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'20006,075,054'Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them'20006,057,322'Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them'20006,025,349'Phenyl.-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them'20006,022,899'Substituted benzyloxy-carbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them'20006,011,063'Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them'20006,005,010'Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'19996,001,881'Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them'19995,998,481'Fluoroalkyl/alkenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'19995,968,978'Biphenylsulfonylcyanamides, process for their preparation, and their use as medicament'19995,965,744'Ortho-substituted benzoylguanidines, including composition and methods of using them'19995,883,133'Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them'19995,880,156'Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them'19995,869,531'Fluoroalkyl substituted benzoylguanidines'19995,866,610'Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them'19995,856,574'Ortho-subsituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'19995,856,344'Sulfonylamino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic aid, and medicament containing them'19995,849,775'Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them'19985,756,535'Substituted thiophenylalkenylcarboxylic acid guanidines, processes for their preparation, their use as a medicament or diagnositc, and a medicament containing them'19985,753,710'Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them'19985,750,728'Process for the preparation of aromatic bromomethyl compounds'19985,747,541'Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them'19985,731,350'Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them'19985,719,169'Substituted benzoylguanidines, their use as a medicament or diagnostic, and medicament containing them'19985,708,034'Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them'19985,698,581'Substituted N-heteroaroylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them'19975,679,712'Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them'19975,670,544'Substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them'19975,641,792'Benzoylguanidines substituted by heterocyclic N-oxide, process for their preparation and pharmaceutical compositions containing them'19975,635,525'Benzimidazole derivatives as angiotensin II receptor antagonists, pharmacticals, and treatment of hypertension therewith'19975,631,293'Preparation of amino acid-substituted benzoylguanidines as diagnostic agents'19975,612,365'Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease'19975,591,754'Benzoylguanidines, pharmaceutical composition containing them and treatment of arrthythmias therewith'19975,571,842'Perfluoroalkyl-substituted, benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them'19965,567,734'Phenyl-substituted alkylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them'19965,559,153'Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them'19965,547,953'Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-dioxo-2H-1,2-benzothiazinoylguanidines, a process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them'19965,516,805'3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them'19965,482,957'Azole derivatives, process for their preparation and their use'19965,475,004'Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease'19955,468,764'Angiotensin II receptor antagonists for the treatment of disturbances in cardiac rhythm'19955,444,068'Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith'19955,235,057'Aminodiol derivatives'19934,855,286'Renin-inhibiting di- and tripeptides, a process for their preparation, agents containing them, and their use'19894,496,723'Process for the preparation of 7-amino-1-dethia-1-oxa-3-hydroxymethyl-cephem-4-carboxylic acids'1985Career & activity timeline
Assembled from patent assignee/location history and declaration credentials.
1989–2003Patents assigned to HOECHST AG (49)· patent assignee history
1989–1993Based in Kelsterbach, DE· patent location history
1995–2003Based in Bad Homburg, DE· patent location history
1996–2015Based in Bischofsheim, DE· patent location history
2000–2005Patents assigned to AVENTIS PHARMA GMBH (19)· patent assignee history
2000Based in Bishchofsheim, DE· patent location history
2006–2013Patents assigned to SANOFI AVENTIS DEUTSCHLAND (23)· patent assignee history
2009–2017Based in Frankfurt am Main, DE· patent location history
2011–2013Patents assigned to KLEEMANN HEINZ-WERNER (9)· patent assignee history
2012–2017Patents assigned to SANOFI SA (7)· patent assignee history
Inventor activity
Assignee and location history derived from the patent record.
Assignees
| Assignee | Patents | Span |
|---|---|---|
| HOECHST AG | 49 | 1989–2003 |
| SANOFI AVENTIS DEUTSCHLAND | 23 | 2006–2013 |
| AVENTIS PHARMA GMBH | 19 | 2000–2005 |
| KLEEMANN HEINZ-WERNERself | 9 | 2011–2013 |
| SANOFI SA | 7 | 2012–2017 |
Locations
| Location | Patents | Span |
|---|---|---|
| Bischofsheim, DE | 70 | 1996–2015 |
| Bad Homburg, DE | 21 | 1995–2003 |
| Frankfurt am Main, DE | 9 | 2009–2017 |
| Kelsterbach, DE | 2 | 1989–1993 |
| Bishchofsheim, DE | 1 | 2000 |