Inventor

Stephen R. Quake

Inventor

Stanford, CA, US

Overview

1999–2021

Patent span

Performing operations

Primary field (CPC B)

Patents· 175 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

B01Lprimary

B01LChemical or physical laboratory apparatus for general use12%

C12QMeasuring or testing processes involving enzymes, nucleic acids or microorganisms12%

Y10TTechnical subjects covered by former us classification9%

G01NInvestigating or analysing materials by determining their chemical or physical properties7%

F16KValves6%

F04BPositive-displacement machines for liquids6%

B01JChemical or physical processes, e.g. catalysis or colloid chemistry5%

B81BMicrostructural devices or systems, e.g. micromechanical devices4%

F15CFluid-circuit elements predominantly used for computing or control purposes3%

B81CProcesses or apparatus specially adapted for the manufacture or treatment of microstructural devices or systems3%

PatentTitleYear

11,130,995Simultaneous determination of aneuploidy and fetal fraction2021 11,098,350Non-invasive diagnosis of graft rejection in organ transplant patients2021 10,988,804Nucleic acid sequencing apparatus for monitoring status of a transplant recipient2021 10,982,275Non-invasive diagnosis of graft rejection in organ transplant patients2021 10,968,479Non-invasive diagnosis of graft rejection in organ transplant patients2021 10,940,473Microfluidic nucleic acid analysis2021 10,774,383Measurement and comparison of immune diversity by high-throughput sequencing2020 10,774,382Measurement and comparison of immune diversity by high-throughput sequencing2020 10,718,010Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free DNA2020 10,669,585Noninvasive diagnosis of fetal aneuploidy by sequencing2020 10,527,193Elastomeric focusing valves2020 10,509,018Apparatus and methods for conducting assays and high throughput screening2019 10,494,669Non-invasive diagnosis of graft rejection in organ transplant patients2019 10,450,620Cell-free nucleic acids for the analysis of the human microbiome and components thereof2019 10,329,607Non-invasive diagnosis of graft rejection in organ transplant patients2019 10,328,428Apparatus for preparing cDNA libraries from single cells2019 10,287,632Methods for profiling and quantitating cell-free RNA2019 10,240,204Methods for profiling and quantitating cell-free RNA2019 10,240,200Methods for profiling and quantitating cell-free RNA2019 10,219,696Implantable pressure sensors for telemetric measurements through bodily tissues2019 10,196,689Measurement and comparison of immune diversity by high-throughput sequencing2019 10,155,250Microfabricated elastomeric valve and pump systems2018 10,155,986Methods for profiling and quantitating cell-free RNA2018 10,117,911Compositions and methods to treat herpes simplex virus infections2018 10,072,295Non-invasive fetal genetic screening by digtal analysis2018 10,066,241Compositions and methods of delivering treatments for latent viral infections2018 10,016,132Implantable micro-fluidic device for monitoring of intra-ocular pressure2018 9,944,982Surface chemistry and deposition techniques2018 9,932,687High throughput screening of crystallization of materials2018 9,909,180'Measurement and comparison of immune diversity by high-throughput sequencing'2018 9,850,483Methods and systems for analysis of single cells2017 9,845,497Non-invasive diagnosis of graft rejection in organ transplant patients2017 9,777,329'Non-invasive fetal genetic screening by digital analysis'2017 9,777,328'Non-invasive fetal genetic screening by digital analysis'2017 9,725,765'Methods for obtaining a sequence'2017 9,719,140'Direct molecular diagnosis of fetal aneuploidy'2017 9,714,443'Microfabricated structure having parallel and orthogonal flow channels controlled by row and column multiplexors'2017 9,643,136'Microfluidic free interface diffusion techniques'2017 9,579,650'Microfluidic nucleic acid analysis'2017 9,487,802'Compositions and methods to treat latent viral infections'2016 9,441,273'Non-invasive fetal genetic screening by digital analysis'2016 9,404,157'Noninvasive diagnosis of fetal aneuploidy by sequencing'2016 9,383,337'Method and apparatus for analysis and sorting of polynucleotides based on size'2016 9,353,414'Noninvasive diagnosis of fetal aneuploidy by sequencing'2016 9,340,765'Microfluidic chemostat'2016 9,329,179'Mechanically induced trapping of molecular interactions'2016 9,329,170'Single cell gene expression for diagnosis, prognosis and identification of drug targets'2016 9,290,811'Measurement and comparison of immune diversity by high-throughput sequencing'2016 9,267,174'Method of simultaneously screening for multiple genotypes and/or mutations'2016 9,249,460'Methods for obtaining a sequence'2016 9,234,240'Measurement and comparison of immune diversity by high-throughput sequencing'2016 9,205,423'High throughput screening of crystallization of materials'2015 9,176,137'Apparatus and methods for conducting assays and high throughput screening'2015 8,992,858'Microfluidic devices and methods of use'2015 8,936,764'Nucleic acid amplification using microfluidic devices'2015 8,932,461'Microfluidic sieve valves'2015 8,877,442'Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale'2014 8,871,446'Microfluidic nucleic acid analysis'2014 8,846,183'Microfabricated elastomeric valve and pump systems'2014 8,709,152'Microfluidic free interface diffusion techniques'2014 8,709,153'Microfludic protein crystallography techniques'2014 8,703,652'Non-invasive diagnosis of graft rejection in organ transplant patients'2014 8,695,640'Microfabricated elastomeric valve and pump systems'2014 8,691,010'Microfluidic protein crystallography'2014 8,682,594'Noninvasive diagnosis of fetal aneuploidy by sequencing'2014 8,673,645'Apparatus and methods for conducting assays and high throughput screening'2014 8,658,368'Microfabricated crossflow devices and methods'2014 8,658,367'Microfabricated crossflow devices and methods'2014 8,656,958'Microfabricated elastomeric valve and pump systems'2014 8,592,215'Microfabricated crossflow devices and methods'2013 8,574,842'Direct molecular diagnosis of fetal aneuploidy'2013 8,550,119'Microfabricated elastomeric valve and pump systems'2013 8,486,636'Nucleic acid amplification using microfluidic devices'2013 8,455,258'Apparatus and methods for conducting assays and high throughput screening'2013 8,445,210'Microfabricated crossflow devices and methods'2013 8,426,159'Microfluidic chemostat'2013 8,388,822'Method and apparatus for analysis and sorting of polynucleotides based on size'2013 8,382,896'High throughput screening of crystallization materials'2013 8,293,470'Non-invasive fetal genetic screening by digital analysis'2012 8,296,076'Noninvasive diagnosis of fetal aneuoploidy by sequencing'2012 8,273,574'Apparatus and methods for conducting assays and high throughput screening'2012 8,268,446'Photocurable perfluoropolyethers for use as novel materials in microfluidic devices'2012 8,257,666'Integrated active flux microfluidic devices and methods'2012 8,252,539'Microfabricated crossflow devices and methods'2012 8,220,487'Microfabricated elastomeric valve and pump systems'2012 8,220,494'Microfluidic large scale integration'2012 8,206,593'Microfluidic chemical reaction circuits'2012 8,206,975'Method and device for regulating fluid flow in microfluidic devices'2012 8,195,415'Noninvasive diagnosis of fetal aneuploidy by sequencing'2012 8,173,001'Method and apparatus for analysis and sorting of polynucleotides based on size'2012 8,129,176'Integrated active flux microfluidic devices and methods'2012 8,124,218'Microfabricated elastomeric valve and pump systems'2012 8,104,497'Microfabricated elastomeric valve and pump systems'2012 8,104,515'Microfabricated elastomeric valve and pump systems'2012 8,052,792'Microfluidic protein crystallography techniques'2011 8,039,269'Mechanically induced trapping of molecular interactions'2011 8,021,480'Microfluidic free interface diffusion techniques'2011 8,017,353'Microfluidic chemostat'2011 8,008,018'Determination of fetal aneuploidies by massively parallel DNA sequencing'2011 8,002,933'Microfabricated elastomeric valve and pump systems'2011 7,981,604'Methods and kits for analyzing polynucleotide sequences'2011 7,964,139'Microfluidic rotary flow reactor matrix'2011 7,927,422'Microfluidic protein crystallography'2011 7,887,753'Apparatus and methods for conducting assays and high throughput screening'2011 7,888,017'Non-invasive fetal genetic screening by digital analysis'2011 7,833,708'Nucleic acid amplification using microfluidic devices'2010 7,766,055'Microfabricated elastomeric valve and pump systems'2010 7,754,010'Microfabricated elastomeric valve and pump systems'2010 7,704,322'Microfluidic free interface diffusion techniques'2010 7,678,547'Velocity independent analyte characterization'2010 7,670,429'High throughput screening of crystallization of materials'2010 7,670,471'Method and apparatus for analysis and sorting of polynucleotides based on size'2010 7,622,081'Integrated active flux microfluidic devices and methods'2009 7,601,270'Microfabricated elastomeric valve and pump systems'2009 7,524,459'Optoelectronic and microfluidic integration for miniaturized spectroscopic devices'2009 7,501,245'Methods and apparatuses for analyzing polynucleotide sequences'2009 7,494,555'Microfabricated elastomeric valve and pump systems'2009 7,479,186'Systems and methods for mixing reactants'2009 7,462,449'Methods and apparatuses for analyzing polynucleotide sequences'2008 7,459,022'Microfluidic protein crystallography'2008 7,413,712'Microfluidic rotary flow reactor matrix'2008 7,407,799'Microfluidic chemostat'2008 7,378,280'Apparatus and methods for conducting assays and high throughput screening'2008 7,351,376'Integrated active flux microfluidic devices and methods'2008 7,326,296'High throughput screening of crystallization of materials'2008 7,306,672'Microfluidic free interface diffusion techniques'2007 7,297,518'Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension'2007 7,294,503'Microfabricated crossflow devices and methods'2007 7,262,923'Microfabricated lenses, method of manufacture thereof, and applications therefor'2007 7,258,774'Microfluidic devices and methods of use'2007 7,250,128'Method of forming a via in a microfabricated elastomer structure'2007 7,247,842'Method and system for scanning apertureless fluorescence mircroscope'2007 7,248,413'Microlensing particles and applications'2007 7,244,402'Microfluidic protein crystallography'2007 7,232,109'Electrostatic valves for microfluidic devices'2007 7,217,321'Microfluidic protein crystallography techniques'2007 7,216,671'Microfabricated elastomeric valve and pump systems'2007 7,214,298'Microfabricated cell sorter'2007 7,211,795'Method for manufacturing single wall carbon nanotube tips'2007 7,195,670'High throughput screening of crystallization of materials'2007 7,192,629'Devices utilizing self-assembled gel and method of manufacture'2007 7,169,314'Microfabricated elastomeric valve and pump systems'2007 7,161,736'Solid immersion lens structures and methods for producing solid immersion lens structures'2007 7,144,616'Microfabricated elastomeric valve and pump systems'2006 7,143,785'Microfluidic large scale integration'2006 7,097,809'Combinatorial synthesis system'2006 7,052,545'High throughput screening of crystallization of materials'2006 7,042,649'Microfabricated rubber microscope using soft solid immersion lenses'2006 7,040,338'Microfabricated elastomeric valve and pump systems'2006 7,038,856'Microfabricated lenses, method of manufacture thereof, and applications therefor'2006 6,964,736'Method and apparatus for analysis and sorting of polynucleotides based on size'2005 6,960,437'Nucleic acid amplification utilizing microfluidic devices'2005 6,958,865'Microlicensing particles and applications'2005 6,953,927'Method and system for scanning apertureless fluorescence microscope'2005 6,947,846'Non-metric tool for predicting gene relationships from expression data'2005 6,929,030'Microfabricated elastomeric valve and pump systems'2005 6,911,345'Methods and apparatus for analyzing polynucleotide sequences'2005 6,899,137'Microfabricated elastomeric valve and pump systems'2005 6,841,096'Microfabricated lenses, methods of manufacture thereof, and applications therefor'2005 6,836,384'Solid immersion lens structures and methods for producing solid immersion lens structures'2004 6,833,242'Methods for detecting and sorting polynucleotides based on size'2004 6,818,395'Methods and apparatus for analyzing polynucleotide sequences'2004 6,804,062'Nonimaging concentrator lens arrays and microfabrication of the same'2004 6,793,753'Method of making a microfabricated elastomeric valve'2004 6,767,706'Integrated active flux microfluidic devices and methods'2004 6,614,598'Microlensing particles and applications'2003 6,608,726'Solid immersion lens structures and methods for producing solid immersion lens structures'2003 6,560,030'Solid immersion lens structures and methods for producing solid immersion lens structures'2003 6,540,895'Microfabricated cell sorter for chemical and biological materials'2003 6,508,988'Combinatorial synthesis system'2003 6,408,878'Microfabricated elastomeric valve and pump systems'2002 6,344,325'Methods for analysis and sorting of polynucleotides'2002 6,301,055'Solid immersion lens structures and methods for producing solid immersion lens structures'2001 6,221,654'Method and apparatus for analysis and sorting of polynucleotides based on size'2001 6,002,471'High resolution scanning raman microscope'1999

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1999–2021Patents assigned to CALIFORNIA INST OF TECHN (121)· patent assignee history

1999–2012Based in Pasadena, CA, US· patent location history

2001–2019Based in San Marino, CA, US· patent location history

2006–2017Patents assigned to UNIV CALIFORNIA (14)· patent assignee history

2007–2021Based in Stanford, CA, US· patent location history

2011–2021Patents assigned to UNIV LELAND STANFORD JUNIOR (45)· patent assignee history

2012–2018Patents assigned to QUAKE STEPHEN R (46)· patent assignee history

2012–2015Patents assigned to CHOU HOU-PU (14)· patent assignee history

2014Based in San Mateo, CA, US· patent location history

2016–2018Based in Palo Alto, CA, US· patent location history

Inventor activity

Assignee and location history derived from the patent record.

Assignees

Assignee	Patents	Span
CALIFORNIA INST OF TECHN	121	1999–2021
QUAKE STEPHEN Rself	46	2012–2018
UNIV LELAND STANFORD JUNIOR	45	2011–2021
CHOU HOU-PU	14	2012–2015
UNIV CALIFORNIA	14	2006–2017

Locations

Location	Patents	Span
Stanford, California, US	86	2007–2021
San Marino, California, US	77	2001–2019
Pasadena, California, US	8	1999–2012
Palo Alto, California, US	2	2016–2018
San Mateo, California, US	1	2014