LexDanaLexDanabeta
Inventor

David R. Liu

Inventor
Lexington, MA, US

Overview

86→
Patents
1993–2020
Patent span
Chemistry
Primary field (CPC C)

Patents· 86 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

C12Nprimary
C12NMicroorganisms or enzymes26%
C07KPeptides16%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations13%
C12PFermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture9%
C12YEnzymes9%
A61KPreparations for medical, dental or toiletry purposes7%
C12QMeasuring or testing processes involving enzymes, nucleic acids or microorganisms6%
H10PGeneric processes or apparatus for the manufacture or treatment of devices covered by class h102%
C40BCombinatorial chemistry2%
H01JElectric discharge tubes or discharge lamps2%
PatentTitleYear
10,858,639CAS9 variants and uses thereof202010,745,677Editing of CCR5 receptor gene to protect against HIV infection202010,704,062CAS9 proteins including ligand-dependent inteins202010,682,410Delivery system for functional nucleases202010,640,767Assay for exo-site binding molecules202010,612,011Evolution of TALENs202010,597,679Switchable Cas9 nucleases and uses thereof202010,508,298Methods for identifying a target site of a CAS9 nuclease201910,465,176Cas variants for gene editing201910,407,474Protein surface remodeling201910,392,674Evolution of site-specific recombinases201910,336,997Continuous directed evolution201910,323,236Evaluation and improvement of nuclease cleavage specificity201910,227,581Engineered transcription activator-like effector (TALE) domains and uses thereof201910,202,593Evolved sortases and uses thereof201910,179,911Negative selection and stringency modulation in continuous evolution systems201910,167,457Nucleobase editors and uses thereof201910,113,163Adenosine nucleobase editors and uses thereof201810,077,453CAS9 proteins including ligand-dependent inteins201810,053,725In situ interaction determination201810,011,868Reactivity-dependent and interaction-dependent PCR20189,999,671Delivery of negatively charged proteins using cationic lipids20189,840,699'Methods for nucleic acid editing'20179,771,574'Apparatus for continuous directed evolution of proteins and nucleic acids'20179,737,604'Use of cationic lipids to deliver CAS9'20179,610,322'Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof'20179,526,784'Delivery system for functional nucleases'20169,434,774'Protein surface remodeling'20169,394,537'Continuous directed evolution'20169,388,430'Cas9-recombinase fusion proteins and uses thereof'20169,359,599'Engineered transcription activator-like effector (TALE) domains and uses thereof'20169,340,800'Extended DNA-sensing GRNAS'20169,340,799'MRNA-sensing switchable gRNAs'20169,322,006'Evaluation and improvement of nuclease cleavage specificity'20169,322,037'Cas9-FokI fusion proteins and uses thereof'20169,267,127'Evolution of bond-forming enzymes'20169,243,038'Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof'20169,228,207'Switchable gRNAs comprising aptamers'20169,221,886'Supercharged proteins for cell penetration'20159,200,045'Small molecule-dependent inteins and uses thereof'20159,175,340'Reactivity-dependent and interaction-dependent PCR'20159,163,284'Methods for identifying a target site of a Cas9 nuclease'20159,163,271'Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs'20159,150,626'Protein surface remodeling'20159,068,179'Methods for correcting presenilin point mutations'20159,023,594'Continuous directed evolution of proteins and nucleic acids'20158,975,232'Macrocyclic kinase inhibitors and uses thereof'20158,691,729'Reaction discovery system'20148,206,914'Evolving new molecular function'20128,183,178'Iterated branching reaction pathways via nucleic acid-mediated chemistry'20128,183,012'Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs'20128,173,392'In vivo incorporation of unnatural amino acids'20128,173,364'Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs'20128,114,648'In vivo incorporation of unnatural amino acids'20128,030,074'In vivo incorporation of unnatural amino acids'20118,017,755'RNA-based transcriptional regulators'20118,017,323'Free reactant use in nucleic acid-templated synthesis'20118,012,739'Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs'20117,998,904'Evolving new molecular function'20117,915,025'In vivo incorporation of unnatural amino acids'20117,851,658'Palladium-catalyzed carbon-carbon bond forming reactions'20107,807,408'Directed evolution of proteins'20107,771,935'Evolving new molecular function'20107,713,721'Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs'20107,678,554'Nucleic acid shuffling'20107,638,300'In vivo incorporation of unnatural amino acids'20097,557,068'Evolving new molecular function'20097,541,450'Ligand-dependent protein splicing'20097,491,494'Evolving new molecular function'20097,476,734'Nucleotide analogs'20097,476,500'In vivo selection system for enzyme activity'20097,442,160'Evolving new molecular function'20087,368,275'In vivo incorporation of unnatural amino acids'20087,354,761'Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs'20087,223,545'Evolving new molecular function'20077,192,739'Ligand-dependent protein splicing'20077,083,970'Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs'20067,070,928'Evolving new molecular function'20067,045,337'In vivo incorporation of unnatural amino acids'20066,017,825'Etch rate loading improvement'20005,835,333'Negative offset bipolar electrostatic chucks'19985,824,605'Gas dispersion window for plasma apparatus and method of use thereof'19985,812,361'Dynamic feedback electrostatic wafer chuck'19985,368,710'Method of treating an article with a plasma apparatus in which a uniform electric field is induced by a dielectric window'19945,356,478'Plasma cleaning method for removing residues in a plasma treatment chamber'19945,226,967'Plasma apparatus including dielectric window for inducing a uniform electric field in a plasma chamber'1993

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1993–2000Patents assigned to LAM RES CORP (7)· patent assignee history
1993–1994Based in San Jose, CA, US· patent location history
1998–2000Based in Saratoga, CA, US· patent location history
2006–2020Patents assigned to HARVARD COLLEGE (64)· patent assignee history
2006–2015Patents assigned to UNIV CALIFORNIA (14)· patent assignee history
2006–2020Based in Lexington, MA, US· patent location history
2008–2012Patents assigned to SCRIPPS RESEARCH INST (11)· patent assignee history
2012–2019Patents assigned to LIU DAVID R (18)· patent assignee history

Inventor activity

Assignee and location history derived from the patent record.

Assignees
AssigneePatentsSpan
HARVARD COLLEGE642006–2020
LIU DAVID Rself182012–2019
UNIV CALIFORNIA142006–2015
SCRIPPS RESEARCH INST112008–2012
LAM RES CORP71993–2000
Locations
LocationPatentsSpan
Lexington, Massachusetts, US792006–2020
Saratoga, California, US41998–2000
San Jose, California, US31993–1994