Inventor

J. Keith Joung

Inventor

Winchester, MA, US

Overview

1999–2021

Patent span

Chemistry

Primary field (CPC C)

Patents· 44 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

C12Nprimary

C12NMicroorganisms or enzymes31%

C07KPeptides21%

C12YEnzymes17%

C12QMeasuring or testing processes involving enzymes, nucleic acids or microorganisms8%

A61KPreparations for medical, dental or toiletry purposes7%

A01KAnimal husbandry5%

G01NInvestigating or analysing materials by determining their chemical or physical properties4%

C40BCombinatorial chemistry2%

A61PSpecific therapeutic activity of chemical compounds or medicinal preparations1%

G16BBioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology1%

PatentTitleYear

11,041,155CCCTC-binding factor variants2021 11,028,429Full interrogation of nuclease DSBs and sequencing (FIND-seq)2021 11,021,718Methods for increasing efficiency of nuclease-induced homology-directed repair2021 10,844,403Increasing specificity for RNA-guided genome editing2020 10,808,233Engineered CRISPR-Cas9 nucleases with altered PAM specificity2020 10,767,168Engineered CRISPR-Cas9 nucleases with altered PAM specificity2020 10,760,064RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci2020 10,738,303Comprehensive in vitro reporting of cleavage events by sequencing (CIRCLE-seq)2020 10,731,167Tale transcriptional activators2020 10,676,749Tale transcriptional activators2020 10,633,642Engineered CRISPR-Cas9 nucleases2020 10,544,433Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing2020 10,526,591Engineered CRISPR-Cas9 nucleases2020 10,526,589Multiplex guide RNAs2020 10,501,794Genomewide unbiased identification of DSBs evaluated by sequencing (GUIDE-seq)2019 10,479,982Engineered CRISPR-Cas9 nucleases with altered PAM specificity2019 10,415,059Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing2019 10,378,027RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci2019 10,273,271Methods of transcription activator like effector assembly2019 10,202,589Engineered CRISPR-Cas9 nucleases with altered PAM specificity2019 10,138,493Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins2018 10,138,476Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing2018 10,119,133Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing2018 10,093,910Engineered CRISPR-Cas9 nucleases2018 10,011,850Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing2018 9,988,674Full interrogation of nuclease DSBs and sequencing (find-seq)2018 9,944,912Engineered CRISPR-Cas9 nucleases with altered PAM specificity2018 9,926,546'Engineered CRISPR-Cas9 nucleases'2018 9,926,545'Engineered CRISPR-CAS9 nucleases with altered PAM specificity'2018 9,890,364'TAL-Tet1 fusion proteins and methods of use thereof'2018 9,885,033'Increasing specificity for RNA-guided genome editing'2018 9,850,484Comprehensive in vitro reporting of cleavage events by sequencing (Circle-seq)2017 9,822,407'Genomewide unbiased identification of DSBs evaluated by sequencing (GUIDE-Seq)'2017 9,752,132'Engineered CRISPR-CAS9 nucleases with altered PAM specificity'2017 9,567,603'Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing'2017 9,567,604'Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing'2017 9,512,446'Engineered CRISPR-Cas9 nucleases'2016 8,846,578'Zinc finger nuclease for the CFTR gene and methods of use thereof'2014 7,919,610'Yeast bacterial two-hybrid system and methods of use thereof'2011 7,504,216'Bacterial counterselectable hybrid systems'2009 7,393,318'Methods and compositions for interaction trap assays'2008 7,297,491'Methods and compositions for interaction trap assays'2007 7,029,847'Methods and compositions for interaction trap assays'2006 5,925,523'Intraction trap assay, reagents and uses thereof'1999

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1999Patents assigned to HARVARD COLLEGE (1)· patent assignee history

1999–2021Based in Winchester, MA, US· patent location history

2006–2008Patents assigned to MASSACHUSETTS INST TECHNOLOGY (3)· patent assignee history

2011–2014Patents assigned to GEN HOSPITAL CORP (2)· patent assignee history

2011Patents assigned to FOX CHASE CANCER CT (1)· patent assignee history

2016–2021Patents assigned to MASSACHUSETTS GEN HOSPITAL (37)· patent assignee history

2021Based in Cambridge, MA, US· patent location history

Inventor activity

Assignee and location history derived from the patent record.

Assignees

Assignee	Patents	Span
MASSACHUSETTS GEN HOSPITAL	37	2016–2021
MASSACHUSETTS INST TECHNOLOGY	3	2006–2008
GEN HOSPITAL CORP	2	2011–2014
FOX CHASE CANCER CT	1	2011
HARVARD COLLEGE	1	1999

Locations

Location	Patents	Span
Winchester, Massachusetts, US	43	1999–2021
Cambridge, Massachusetts, US	1	2021