Inventor
Michael S. Malamas
Inventor
Jamison, PA, US
Overview
Patents· 76 as inventor
Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.
C07Dprimary
C07DHeterocyclic compounds51%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations27%
A61KPreparations for medical, dental or toiletry purposes10%
C07CAcyclic or carbocyclic compounds8%
C07BGeneral methods of organic chemistry1%
C07FAcyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium1%
Y02PClimate change mitigation technologies in the production or processing of goods1%
Y10STechnical subjects covered by former uspc cross-reference art collections [xracs] and digests1%
PatentTitleYear
10,689,357N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof202010,662,159ABHD6 and dual ABHD6/MGL inhibitors and their uses202010,640,494N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof20209,963,444N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof20187,875,618'Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders'20117,732,457'Amino-pyridines as inhibitors of β-secretase'20107,723,368'Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase'20107,705,030'Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation'20107,700,606'Imidazole amines as inhibitors of β-secretase'20107,700,602'Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase'20107,563,796'Diphenylimidazopyrimidines as inhibitors of β-secretase'20097,531,564'Substituted benzoxazoles as estrogenic agents'20097,482,349'Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase'20097,456,186'Diphenylimidazopyrimidines as inhibitors of β-secretase'20087,452,885'Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation'20087,423,158'Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase'20087,417,047'Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation'20087,351,726'Substituted oxadiazolidinediones'20087,148,247'Substituted benzoxazoles as estrogenic agents'20067,141,672'Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia'20067,129,258'Substituted benzoxazoles as estrogenic agents'20067,022,716'Cyclic amine phenyl beta-3 adrenergic receptor agonists'20066,960,607'Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents'20056,884,814'Phenyl benzisoxazoles as estrogenic agents'20056,844,358'Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20056,794,403'Substituted benzoxazoles as estrogenic agents'20046,743,787'N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists'20046,699,896'Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia'20046,569,873'Azolidines as beta-3 adrenergic receptor agonists'20036,525,202'Cyclic amine phenyl beta-3 adrenergic receptor agonists'20036,509,360'Penyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20036,465,501'Azolidines as 3 adrenergic receptor agonists'20026,444,685'N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists'20026,391,897'Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20026,369,072'Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20026,310,081'Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia'20016,232,322'Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20016,221,902'Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia'20016,214,842'Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia'20016,166,069'Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20006,110,963'Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia'20005,914,339'Substituted 1,3-benzodioxoles'19995,677,342'Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents'19975,610,197'Benzyl and naphthalenylmethyl thiophenones and cyclopentenones as antihyperglycemic agents'19975,541,205'Aryl-n-hydroxyureas as inhbitors of 5-lipoxygenase and anti-arteriosclerotic agents'19965,532,256'New azolidinediones and thiadiazolidinediones as antihyperglycemic agents'19965,510,360'Azolidinediones as antihypergylcemic agents'19965,504,097'N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein'19965,491,159'2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents'19965,482,968'Naphthalenylmethyl cycloalkenone acetic acids and analogs thereof useful as aldose reductase inhibitors'19965,480,896'Aralkyl-1,2,4-oxadiazolidine-3,5-diones as antihyperglycemic agents'19965,468,762'Azolidinediones as antihyperglycemic agents'19955,468,760'Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein'19955,459,154'N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein'19955,444,086'Naphthalenylmethyl thiophenones as antihyperglycemic agents'19955,428,048'Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents'19955,420,146'Di-oxadiazolidine derivatives as antihyperglycemic agents'19955,399,588'Naphthalenylmethyl cycloalkenone acetic acids and analogs thereof useful as aldose reductase inhibitors'19955,189,168'1\'-am ino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3\'-pyrrolidine]-1, 2\'3,5\'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors'19935,189,167'Alkylidene analogs of 1\'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3\'-pyrrolidine]-1,2\',3,5\'(2H)-tetrones useful as aldose reductase inhibitors'19935,189,044'Isoquinoline-1,3-dione acetyl carbamates useful as aldose reductase inhibitors'19935,169,948'Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors'19925,130,425'Spiro-lactams and analogs thereof useful as aldose reductase inhibitors'19925,106,978'Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3\'-pyrrolidine)-1,2\', 3,5\'(2H)-tetrones which are useful as aldose reductase inhibitors'19925,102,886'1\'-aminospiro[isoquinoline-4(1H),3\'-pyrrolidine]-1,2\',3,5\'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors'19925,093,496'Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors'19925,081,241'Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors'19925,068,332'Alkylidene analogs of 1\'-aminospiro[isoquinoline-4(1H),3\'-pyrrolidine]-1,2\',3,5\'(2H)-tetrones useful as aldose reductase inhibitors'19915,045,544'N\'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors'19915,037,831'Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors'19914,994,381'N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycin e S-oxide and the amide thereof'19914,983,613'Isoquinoline acetic acids and acetyl carbamates useful as aldose reductase inhibitors'19914,927,831'Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors'19904,853,484'N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylg lycine S-oxide and the amide thereof'19894,743,611'Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful as aldose reductase inhibitors'19884,734,435'N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxome thyl]-N-methylglycine S-oxide and the amide thereof'1988Career & activity timeline
Assembled from patent assignee/location history and declaration credentials.
1988–2002Patents assigned to AMERICAN HOME PROD (41)· patent assignee history
1988–1991Based in Plainsboro, NJ, US· patent location history
1990–2020Based in Jamison, PA, US· patent location history
2002–2011Patents assigned to WYETH CORP (24)· patent assignee history
2010Patents assigned to WYETH LLC (5)· patent assignee history
2011Patents assigned to ELBION GMBH (1)· patent assignee history
2018–2020Patents assigned to UNIV NORTHEASTERN (3)· patent assignee history
2018Based in Boston, MA, US· patent location history
Inventor activity
Assignee and location history derived from the patent record.
Assignees
| Assignee | Patents | Span |
|---|---|---|
| AMERICAN HOME PROD | 41 | 1988–2002 |
| WYETH CORP | 24 | 2002–2011 |
| WYETH LLC | 5 | 2010 |
| UNIV NORTHEASTERN | 3 | 2018–2020 |
| ELBION GMBH | 1 | 2011 |
Locations
| Location | Patents | Span |
|---|---|---|
| Jamison, Pennsylvania, US | 71 | 1990–2020 |
| Plainsboro, New Jersey, US | 4 | 1988–1991 |
| Boston, Massachusetts, US | 1 | 2018 |