Inventor
Robert A. Holton
Inventor
Tallahassee, FL, US
Overview
Patents· 125 as inventor
Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.
C07Dprimary
C07DHeterocyclic compounds33%
C07FAcyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium20%
C07CAcyclic or carbocyclic compounds17%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations14%
Y02PClimate change mitigation technologies in the production or processing of goods9%
A61KPreparations for medical, dental or toiletry purposes5%
C07BGeneral methods of organic chemistry1%
C12PFermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture1%
F16DCouplings for transmitting rotation0%
PatentTitleYear
8,522,930'Clamping assembly employing a shape memory alloy actuating apparatus'20138,242,166'C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes'20128,003,812'C10 cyclopentyl ester substituted taxanes'20117,667,055'Processes for the production of polycyclic fused ring compounds'20107,589,111'C10 cyclopentyl ester substituted taxanes'20097,550,608'Processes for the preparation of docetaxel'20097,541,458'β-lactam synthesis'20097,524,869'Taxanes having a C10 ester substituent'20097,358,378'Processes for the preparation of paclitaxel'20087,288,665'Process for selective derivatization of taxanes'20077,256,213'Taxanes having a C10 carbonate substituent'20077,230,013'C10 carbamoyloxy substituted taxane compositions'20077,226,944'Taxanes having a C7 carbonate substituent'20077,186,849'C7 ester substituted taxanes'20077,183,312'Taxanes having a C7 heterosubstituted acetate substituent'20077,160,919'C7 lactyloxy-substituted taxanes'20077,157,474'C10 heterosubstituted acetate taxane compositions'20077,074,945'Metal alkoxide taxane derivatives'20067,067,552'Radiosensitizing taxanes and their pharmaceutical preparations'20067,067,305'Enzymatic process for the resolution for enantiomeric mixtures of β-lactams'20067,056,946'C10 carbonate taxane compositions'20067,019,150'1-deoxy taxol analogs'20066,992,104'C7 carbonate taxane compositions'20066,906,088'Taxanes having a C10 carbamoyloxy substituent'20056,878,834'14-hydrido-9β-hydroxytetracyclic taxanes'20056,878,833'Tetraalkylammonium alkoxides'20056,872,842'Butenyl substituted taxanes'20056,872,837'Taxanes having a c10 Heterosubstituted acetate substituent'20056,861,446'C7 heterosubstituted acetate taxane compositions'20056,861,537'Tricyclic and tetracyclic taxane intermediates'20056,797,833'C9 hydrido and acyloxy metal alkoxides'20046,794,523'Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them'20046,780,879'C7 carbonate substituted taxanes'20046,762,309'C7 acyloxy metal alkoxides'20046,750,245'C7 carbamate substituted taxanes'20046,730,782'Carbamoyl substituted -lactams'20046,727,369'Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups'20046,710,191'9-hydroxytetracyclic taxanes'20046,706,896'Process for selective derivatization of taxanes'20046,683,196'Process for the preparation of metal alkoxides'20046,673,833'C7 heterosubstituted acetate taxanes'20046,664,275'C10 heterosubstituted acetate taxanes'20036,660,866'C10 carbonate substituted taxanes'20036,653,490'Process for the preparation of ammonium alkoxides'20036,649,632'C10 ester substituted taxanes'20036,649,777'C2 substituted taxanes'20036,638,973'Taxane formulations'20036,630,609'Taxane synthesis method and intermediates'20036,620,950'Method for the preparation of 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs'20036,610,860'C7 ester substituted taxanes'20036,596,737'C10 carbamoyloxy substituted taxanes'20036,562,962'Preparation of substituted isoserine esters using metal alkoxides and -lactams'20036,552,205'C10 OXO and hydrido taxane derivatives and pharmaceutical compositions containing them'20036,548,293'Enzymatic process for the resolution of enantiomeric mixtures of -lactams'20036,545,168'1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof'20036,521,660'3-alkyl substituted taxanes and pharmaceutical compositions containing them'20036,495,704'9-desoxotaxanes and process for the preparation of 9-desoxotaxanes'20026,482,963'C9 hydrido, hydroxy and acyloxy taxane derivatives and pharmaceutical compositions containing them'20026,479,678'Metal alkoxide taxane and -lactam compounds'20026,462,208'C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them'20026,458,977'Preparation of substituted isoserine esters using -lactams and metal or ammonium alkoxides'20026,441,253'Method for the synthesis of taxanes'20026,433,189'Tricyclic and tetracyclic taxane intermediates'20026,395,895'Butenyl substituted -lactams'20026,369,244'C13 amido substituted taxane derivatives and pharmaceutical compositions containing them'20026,359,154'C7 carbamoyloxy substituted taxanes'20026,339,164'C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them'20026,335,362'Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them'20026,291,692'9-desoxobaccatin III and analogs thereof'20016,291,691'Process for selective derivatization of taxanes'20016,278,026'Intermediates for tricyclic or tetracyclic taxanes'20016,191,287'Process for selective derivatization of taxanes'20016,147,234'C9 taxane derivatives'20006,124,481'Ammonium alkoxides'20006,111,144'Method for the synthesis of a taxane intermediate'20006,069,260'Metal alkoxides'20006,066,747'Process for the preparation of 9-desoxotaxanes'20006,051,724'Amino substituted taxanes'20006,028,205'C2 tricyclic taxanes'20006,018,073'Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them'20006,011,056'C9 taxane derivatives and pharmaceutical compositions containing them'20006,005,120'Tricyclic and tetracyclic taxanes'19996,005,138'Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them'19995,998,656'C10 tricyclic taxanes'19995,994,576'C7 tricyclic taxanes'19995,990,325'Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof'19995,760,219'Pyridyl substituted B-lactam compounds'19985,760,252'Synthetic process for the preparation of tricyclic and tetracyclic taxanes'19985,739,362'Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them'19985,728,850'Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them'19985,728,725'C2 taxane derivaties and pharmaceutical compositions containing them'19985,723,634'Metal alkoxide compounds'19985,721,268'C7 taxane derivatives and pharmaceutical compositions containing them'19985,717,115'Metal alkoxides and ammonium alkoxides'19985,714,513'C10 taxane derivatives and pharmaceutical compositions'19985,710,287'Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them'19985,654,447'Process for the preparation of 10-desacetoxybaccatin III'19975,637,732'Tricyclic and tetracyclic taxanes'19975,618,952'Synthetic process for the preparation of tricyclic and tetracyclic taxanes'19975,587,489'Taxane and baccatin III analogs bearing new C2 and C4 functional groups'19965,574,156'.beta.-lactams used in preparing taxol'19965,539,103'.beta.-lactams as taxol intermediates N-acylated'19965,532,363'Heteroaryl substituted oxazinone compounds for the preparation of taxol'19965,489,601'Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them'19965,466,834'Preparation of substituted isoserine esters using metal alkoxides and .beta .'19955,430,160'Preparation of substituted isoserine esters using .beta.-lactams and metal or ammonium alkoxides'19955,405,972'Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes'19955,399,726'Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups'19955,384,399'Oxazinone compounds for the preparation of taxol'19955,350,866'10-desacetoxytaxol derivatives'19945,338,872'Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof'19945,336,785'Method for preparation of taxol'19945,284,864'Butenyl substituted taxanes and pharmaceutical compositions containing them'19945,284,865'Cyclohexyl substituted taxanes and pharmaceutical compositions containing them'19945,283,253'Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them'19945,274,124'Metal alkoxides'19935,254,703'Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones'19935,250,683'Certain substituted taxanes and pharmaceutical compositions containing them'19935,243,045'Certain alkoxy substituted taxanes and pharmaceutical compositions containing them'19935,229,526'Metal alkoxides'19935,227,400'Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them'19935,175,315'Method for preparation of taxol using .beta.-lactam'19925,136,060'Method for preparation of taxol using an oxazinone'19925,015,744'Method for preparation of taxol using an oxazinone'19914,876,399'Taxols, their preparation and intermediates thereof'1989Career & activity timeline
Assembled from patent assignee/location history and declaration credentials.
1989–2012Based in Tallahassee, FL, US· patent location history
1991–2007Patents assigned to UNIV FLORIDA STATE (90)· patent assignee history
1994–2013Patents assigned to HOLTON ROBERT A (3)· patent assignee history
1994Patents assigned to BRISTOL MYERS SQUIBB CO (1)· patent assignee history
2002–2007Patents assigned to FSU RES FOUNDATION INC (21)· patent assignee history
2007–2012Patents assigned to UNIV FLORIDA STATE RES FOUND (11)· patent assignee history
2013Based in Orlando, FL, US· patent location history
Inventor activity
Assignee and location history derived from the patent record.
Assignees
| Assignee | Patents | Span |
|---|---|---|
| UNIV FLORIDA STATE | 90 | 1991–2007 |
| FSU RES FOUNDATION INC | 21 | 2002–2007 |
| UNIV FLORIDA STATE RES FOUND | 11 | 2007–2012 |
| HOLTON ROBERT Aself | 3 | 1994–2013 |
| BRISTOL MYERS SQUIBB CO | 1 | 1994 |
Locations
| Location | Patents | Span |
|---|---|---|
| Tallahassee, Florida, US | 124 | 1989–2012 |
| Orlando, Florida, US | 1 | 2013 |