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Inventor

George Y. Lesher

Inventor
Schodack, NY, US

Overview

113→
Patents
1976–1996
Patent span
Chemistry
Primary field (CPC C)

Patents· 113 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

C07Dprimary
C07DHeterocyclic compounds73%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations19%
A61KPreparations for medical, dental or toiletry purposes6%
C07CAcyclic or carbocyclic compounds3%
PatentTitleYear
5,541,187'6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compositions and method of use thereof'19965,308,843'Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids'19945,294,612'6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof'19945,169,853'Pyridinyl-quinolone compounds, their preparation and use'19925,075,319'Pyridinyl-quinolone compounds, their preparation and use'19915,010,086'Imidazopyridines, compositions and use'19914,963,561'Imidazopyridines, their preparation and use'19904,898,880'N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use'19904,839,355'Tricyclic-pyridinylquinoline compounds, their preparation and use'19894,716,170'5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use'19874,698,350'1-ethyl-6-fluoro-1,4-dihydro- 7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof'19874,697,021'1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents'19874,657,915'1,6-naphthyridine-2(1H)-ones and their use as cardiotonic agents'19874,650,806'Cardiotonic 5-(heterylcarbonyl)-pyridones'19874,634,772'2-[2-(di-lower-alkylamino)-1 -propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents'19874,604,399'5-methyl(or ethyl)-1,6-naphthyridin-2(1H)-one 6-oxides, their preparation and the cardiotonic use thereof'19864,599,423'Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones'19864,595,762'5-.alpha.-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles'19864,590,194'3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use'19864,567,186'5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor'19864,560,691'5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation'19854,560,753'2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones'19854,559,347'3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic use and preparation thereof'19854,559,352'1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof'19854,539,327'5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof'19854,532,247'5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof'19854,524,149'5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use'19854,517,190'5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof'19854,517,192'6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics'19854,515,797'3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof'19854,512,993'4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereof'19854,506,075'Process of preparing cardiotonic 3-methyl-4-(4-pyridinyl)benzeneamines'19854,504,482'[5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use thereof'19854,503,228'2-(Pyridinyl)-4,5,6-pyrimidinetriamines'19854,486,431'Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones'19844,473,571'8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use'19844,469,699'5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use'19844,465,686'5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation'19844,463,008'2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof'19844,451,469'Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics'19844,448,780'N-(Lower-alkyl)-N\'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof'19844,432,981'2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones'19844,431,651'2-Pyridinones and their use as cardiotonic agents'19844,420,617'5(Pyridinyl)pyridin-2-amines'19834,415,578'Cardiotonic 3-methyl-4-(4-pyridinyl)benzeneamine compositions and method of use'19834,415,580'Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same'19834,412,077'Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone'19834,391,811'2-Amino-6-(pyridinyl)-3H-imidazo[4,5-b]pyridines and their cardiotonic use'19834,377,585'Use of 4-[4(or 3)-aminophenyl]pyridines as cardiotonic agents'19834,376,775'N-[4-(4-Pyridinyl)phenyl]ureas and their cardiotonic use'19834,375,467'5-(Pyridinyl)-1H-pyrazolo[3,4-b] pyridines and their cardiotonic use'19834,374,141'2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use'19834,366,319'Process for preparing 5-(pyridinyl)benzoxazol-2(3H)-ones'19824,365,065'1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones'19824,363,911'1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles'19824,362,735'3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use'19824,362,734'2-(Substituted-amino)-5-(pyridinyl-nicotinonitriles, and their cardiotonic use'19824,361,569'3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof'19824,361,568'5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use'19824,354,026'3-Chloro-6-(pyridinyl)-pyridazines'19824,351,941'Pyridinyl-pyridines'19824,346,221'Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones'19824,339,584'Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones via N-hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide by reaction with polyphosphoric acid'19824,338,446'Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates'19824,337,253'4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic'19824,335,132'5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols'19824,331,672'5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use'19824,322,533'1H-Indole-2,3-dione derivatives'19824,317,827'4-[4(or 3)-Acylaminophenyl]pyridines and their use as cardiotonics'19824,317,909'Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones'19824,313,951'3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor'19824,312,875'5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof'19824,310,531'5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonics'19824,309,537'Production of imidazo[4,5-b]pyridin-2-ones or thiones'19824,305,948'N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use'19814,305,943'4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics'19814,304,776'4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics'19814,304,775'3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof'19814,304,777'6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics'19814,302,462'4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use and cardiotonic use of their methyl ethers'19814,298,609'4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents'19814,297,362'4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardiotonic'19814,297,363'2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotonics'19814,297,360'5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use'19814,294,836'1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use'19814,294,837'1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use'19814,276,293'Compositions and their preparation'19814,271,168'Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones'19814,265,895'1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics'19814,264,603'5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation'19814,264,612'Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics'19814,225,601'3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation'19804,225,715'Preparation of 3-amino(or carbamyl)-5-(pyridinyl)-2(1H)-pyridinones'19804,223,149'Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones'19804,199,586'Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates'1980RE030024'4-Amino (or hydrazino)-2-(pyridinyl)pyrimidines'19794,137,233'1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides'19794,137,227'1-Alkyl-1,4-dihydro-4-oxo-7-triazenyl-3-quinolinecarboxylic acids'19794,118,571'4-Acylamino-2-(pyridinyl)pyrimidine derivatives'19784,118,557'Cyclic alkylidenyl N-(lower-alkyl)-3-(pyridinyl)anilinomethylenemalonates'19784,109,092'Preparation of 2-(pyridinyl)-4-pyrimidinamines'19784,107,315'5-(Pyridinyl)-2(1H)-pyridinones'19784,104,385'Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates'19784,086,233'4-(Substituted-amino)-2-(pyridinyl) pyrimidine derivatives'19784,072,746'3-Amino-5-(pyridinyl)-2(1H)-pyridinones'19784,053,475'N-[2-(Pyridinyl)-4-pyrimidinyl]ureas preparation'19774,032,523'4-Amino (or halo or hydroxy or hydrazino)-2-(pyridinyl)pyrimidines'19774,018,770'N-(2-(pyridinyl)-4-pyrimidinyl)-aminomethylenemalonates and analogs'19774,009,208'N,N\'-Heptamethylenebis(4-methoxybenzamide)'19774,008,235'N-[2-(pyridinyl)-4-pyrimidinyl]ureas'19774,004,012'3-Cyano-5-(pyridinyl)-2(1H)-pyridinones'19773,992,380'5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters'19763,960,945'4-[-(Alkoxy or polyhaloalkoxy)-benzamido]cyclohexanones'1976

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1976–1994Patents assigned to STERLING DRUG INC (109)· patent assignee history
1976–1981Based in Rensselaer, NY, US· patent location history
1977–1982Based in East Greenbush, NY, US· patent location history
1978–1996Based in Schodack, NY, US· patent location history
1981–1983Based in Shodack, NY, US· patent location history
1982Patents assigned to GRUETT MONTE D (1)· patent assignee history
1982Patents assigned to LESHER GEORGE Y (1)· patent assignee history
1982Patents assigned to PAGE DONALD F (1)· patent assignee history
1989Based in Schodak, NY, US· patent location history
1994–1996Patents assigned to STERLING WINTHROP INC (2)· patent assignee history

Inventor activity

Assignee and location history derived from the patent record.

Assignees
AssigneePatentsSpan
STERLING DRUG INC1091976–1994
STERLING WINTHROP INC21994–1996
GRUETT MONTE D11982
LESHER GEORGE Yself11982
PAGE DONALD F11982
Locations
LocationPatentsSpan
Schodack, New York, US981978–1996
Rensselaer, New York, US61976–1981
East Greenbush, New York, US51977–1982
Shodack, New York, US31981–1983
Schodak, New York, US11989