Inventor

Milan R. Uskokovic

Inventor

Upper Montclair, NJ, US

Overview

1976–2009

Patent span

Chemistry

Primary field (CPC C)

Patents· 118 as inventor

Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.

C07Dprimary

C07DHeterocyclic compounds24%

C07CAcyclic or carbocyclic compounds22%

A61KPreparations for medical, dental or toiletry purposes15%

C07FAcyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium12%

A61PSpecific therapeutic activity of chemical compounds or medicinal preparations8%

C07JSteroids6%

C07BGeneral methods of organic chemistry5%

Y02PClimate change mitigation technologies in the production or processing of goods2%

C07HSugars2%

A61QSpecific use of cosmetics or similar toiletry preparations2%

PatentTitleYear

7,491,711'Methods of treatment using 3-desoxy vitamin D3 analogs'2009 6,559,138'3-Desoxy-vitamin D3 analog esters'2003 6,492,353'1,3-dihydroxy-20,20-cycloalkyl-vitamin D3analogs'2002 6,452,028'Vitamin D3 analogs'2002 6,331,642'Vitamin D3 analogs'2001 6,329,538'Vitamin D3 analogs'2001 6,040,461'Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs'2000 6,030,962'Vitamin D.sub.3 analogs with bis C-20 side chains'2000 6,030,963'16-ene-26,27-bishomo cholecalciferols'2000 6,008,209'Method of using vitamin D.sub.3 analogs with bis C-20 side chains'1999 5,939,408'Vitamin D.sub.3 analogs'1999 5,891,866'Methods of treatment'1999 5,888,994'Fluorinated Vitamin D.sub.3 analogs'1999 5,872,113'Fluorinated vitamin D3 analogs'1999 5,856,317'Methods of treatment'1999 5,840,718'22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol'1998 5,811,414'Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin'1998 5,804,574'Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin'1998 5,753,638'Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs'1998 5,750,517'Method of treating sebaceous gland diseases with vitamin D.sub.3 fluorinated analogs'1998 5,747,479'Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin'1998 5,696,103'Method for treating osteoporosis'1997 5,612,328'Vitamin D3 fluorinated analogs'1997 5,547,947'Methods of treatment'1996 5,512,554'Method of treating hyperproliferative skin diseases with fluorinated vitamin D.sub.3 analogs'1996 5,451,574'Vitamin D3 Flourinated Analogs'1995 5,428,029'Vitamin D3 fluorinated analogs'1995 5,401,733'Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol'1995 5,393,900'Steroid intermediates for the formation of vitamin D.sub.3 analogues'1995 5,384,314'1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol'1995 5,342,833'Vitamin D3 analogs'1994 5,258,559'Process for the preparation of [1R-(1.beta.(R*), 3a.alpha., 4.beta., 7a.beta.)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one'1993 5,247,123'Deuterated analogs of 1,25-dihydroxycholecalciferol'1993 5,200,549'Antipsoriatic agents'1993 5,149,846'Deuterated analogs of 1,25-dihydroxycholecalciferol'1992 5,145,846'Vitamin D3 analogs'1992 5,120,722'Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia'1992 5,110,958'Compounds, process and intermediates'1992 5,087,619'Vitamin D.sub.3 analogs'1992 5,075,327'Antipsoriatic agents'1991 5,073,568'Antipsoriatic agents'1991 5,039,671'Trifluorinated-1.alpha.,25S-dihydroxy vitamin D3 compounds'1991 5,021,451'Method for inhibiting hyperproliferative diseases'1991 4,929,609'25, 28-dihydroxyergocalciferol and 1,25,28-trihydroxyergocalciferol compositions thereof and their use in the treatment of hyperproliferative disease'1990 4,898,855'Deuterated analogs of 1,25-dihydroxycholecalciferol'1990 4,883,791'25S,26-dihydroxycholecalciferol in the treatment of hypercalcitriolemic disease states'1989 4,804,502'Vitamin D compounds'1989 4,652,405'Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol'1987 4,634,692'Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol'1987 4,632,784'Process for the preparation of 1.alpha.,23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone'1986 4,617,297'Method of treating disease states by the administration of 1.alpha.,25,26-trihydroxycholecalciferol'1986 4,613,594'Fluorinated vitamin D.sub.3 compounds'1986 4,612,308'25,26-Dehydro-1.alpha.,23(S,R)-dihydroxycholecalciferol and its epimers'1986 4,599,330'Method of treating milk fever'1986 4,595,776'Synthesis of 1.alpha.,25-dihydroxyergocalciferol'1986 4,594,432'Process for the synthesis of 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol'1986 4,594,340'25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol and 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol and the epimeric mixture'1986 4,508,651'Synthesis of 1.alpha.,25-dihydroxyergocalciferol'1985 4,428,963'Novel thiophene derivatives'1984 4,421,690'Process for the preparation of 24,24-difluoro-1.alpha.,25-dihydroxy vitamin D.sub.3 and intermediates obtained therefrom'1983 4,415,742'Tetrahydro-5-(1-hydroxyethyl)-2-hydroxy-N(1-arylhydrocarbyl )furan-4-carbamic acid alkyl esters'1983 4,414,402'[2S-(2.beta.,2S*, 3.beta.)]-3-Aminotetrahydro-5-methoxy-.alpha.-methyl-2-furanmethanol, an intermediate in the chiral synthesis of amino sugars'1983 4,397,847'Method of treatment'1983 4,382,031'Intermediates for the preparation of biotin'1983 4,376,207'Chiral synthesis of amino sugars'1983 4,360,470'Process and intermediates for the synthesis of Vitamin D.sub.3 metabolites and chenodeoxycholic acid'1982 4,360,681'Novel thiophene compounds'1982 4,337,345'Preparation of biotin via thieno [3,2c] isoxazoles'1982 4,335,120'Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials'1982 4,324,726'Chiral synthesis of amino sugars'1982 4,320,056'Certain thia-diazatricyclo[3,3,3,0.sup.8,11 ]tridecanes, and their preparation'1982 4,317,915'Novel thiophene derivatives'1982 4,310,462'Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside'1982 4,310,467'Process and intermediates for the synthesis of vitamin D.sub.3 metabolites'1982 4,301,246'Process for chenodeoxycholic acid production'1981 4,299,968'Novel thiophene compounds'1981 4,284,557'Intermediate racemates for the preparation of biotin and a process for their preparation'1981 4,252,964'Furo[3,2-C]isoxazol-5-ones'1981 4,247,704'Hexahydro thieno imadazole intermediates for the synthesis of biotin'1981 4,245,104'Isoxazolines and isoxazolidines'1981 4,238,399'3,4-Anhydro-2,6-dideoxy-L-ribohexose'1980 4,230,701'Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials'1980 4,230,625'Process for chenodeoxycholic acid and intermediates therefore'1980 4,228,295'Novel cycloheptathiophene intermediates for the synthesis of biotin'1980 4,228,080'Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside'1980 4,225,525'Vitamin D.sub.3 metabolite derivatives'1980 4,189,586'Preparation of biotin'1980 4,180,659'Coumarin derivatives to produce 8-methoxypsoralen'1979 4,175,086'Cycloheptathiophene derivatives'1979 4,174,344'Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside'1979 4,140,708'Asymmetric synthesis of optically active prostaglandins'1979 4,137,244'Asymmetric synthesis of optically active prostaglandins'1979 4,133,818'Process for producing lactones'1979 4,130,568'8-Methoxypsoralen derivatives'1978 4,130,713'Biotin intermediates'1978 4,127,736'2-Hydroxyethyl-3-cyclopenten-1-ols and derivatives thereof'1978 4,124,595'Synthesis of biotin'1978 4,115,452'4,5, Substituted cyclopentane-1,3-diols'1978 4,096,146'4-[5(R)-Alkyl(or alkenyl)-4(S)-quinuclidin-2(S) or 2(R)-ylcarbonyl]-quinolines, antipodes or racemates thereof and processes for their preparation'1978 4,062,868'Synthesis of biotin'1977 4,038,272'Stereospecific syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof'1977 4,029,647'Synthesis of biotin'1977 4,028,349'Syntheses of 24R,25- and 24S,25-dihydroxycholesterol 24,25-ketals and alkanoyl derivatives thereof'1977 4,026,882'Syntheses of 3,24R,25- and 3,24S,25-trihydroxy-5,7-cholestadiene 24,25-ketals and alkanoyl derivatives thereof'1977 4,012,396'Processes and intermediates for cis or trans 2-or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters'1977 4,009,172'2,3,3A,6,7,7A-Hexahydro-thieno[3,2-b]pyridin-(4H)5-ones'1977 3,994,878'Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof'1976 3,993,675'Process for the preparation of 1.alpha.,25-dihydroxycholecalciferol'1976 3,979,396'Synthesis of biotin'1976 3,978,084'Synthesis of biotin'1976 3,959,294'Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters'1976 3,957,800'Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters'1976 3,957,794'3-Amino-2,3,3a,6,7,7a-hexahydro-thieno[3,2-b]pyridin-(4H)5-one'1976 3,956,316'11-Substituted-desA-pregnanes and derivatives thereof'1976 3,953,453'Trifluoromethyl substituted analogs of quinine and quinidine'1976 3,933,892'Asymmetric synthesis of optically active prostaglandins'1976 3,931,193'Quinuclidine derivatives'1976 3,931,192'Process for piperidine intermediates for quinine, quinidine and analogs thereof'1976

Career & activity timeline

Assembled from patent assignee/location history and declaration credentials.

1976–2002Patents assigned to HOFFMANN LA ROCHE (113)· patent assignee history

1976–2009Based in Upper Montclair, NJ, US· patent location history

1976Based in Montclair, NJ, US· patent location history

1989Patents assigned to HOFFMAN LAROCHE INC (1)· patent assignee history

1995Patents assigned to REDDY SATYANARAYAMA G (1)· patent assignee history

1997–2000Patents assigned to SYNTEX INC (4)· patent assignee history

2002–2003Patents assigned to SYNTEX LLC (2)· patent assignee history

Inventor activity

Assignee and location history derived from the patent record.

Assignees

Assignee	Patents	Span
HOFFMANN LA ROCHE	113	1976–2002
SYNTEX INC	4	1997–2000
SYNTEX LLC	2	2002–2003
HOFFMAN LAROCHE INC	1	1989
REDDY SATYANARAYAMA G	1	1995

Locations

Location	Patents	Span
Upper Montclair, New Jersey, US	117	1976–2009
Montclair, New Jersey, US	1	1976