Inventor
Robert S. Langer
Inventor
Newton, MA, US
Overview
Patents· 413 as inventor
Public. Assignee & technology derived from the patent record. Each patent links to its LexDana page.
A61Kprimary
A61KPreparations for medical, dental or toiletry purposes22%
A61PSpecific therapeutic activity of chemical compounds or medicinal preparations10%
C12NMicroorganisms or enzymes8%
A61LMethods or apparatus for sterilising materials or objects in general6%
C08GMacromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds5%
Y10STechnical subjects covered by former uspc cross-reference art collections [xracs] and digests3%
A61FFilters implantable into blood vessels3%
Y10TTechnical subjects covered by former us classification3%
A61MDevices for introducing media into, or onto, the body3%
C08LCompositions of macromolecular compounds3%
PatentTitleYear
11,125,739Gene editing through microfluidic delivery202111,111,472Delivery of biomolecules to immune cells202111,090,413Modified alginates for anti-fibrotic materials and applications202111,083,690Enteric elastomers202111,077,056Residence structures and related methods202111,045,429Shear-thinning self-healing networks202111,021,687Production of differentiated enteroendocrine cells and insulin producing cells202110,874,621Cationic nanoparticles for co-delivery of nucleic acids and therapeutic agents202010,870,112Selective delivery of material to cells202010,864,303Method comprising contacting tissue with a cross-linkable polyester prepolymer202010,864,162Mass production and size control of nanoparticles through controlled microvortices202010,868,284Safely ingestible batteries and methods202010,851,069Compositions of crystallized hydrophobic compounds and methods of making and using same202010,849,853Self-assembled residence devices and related methods202010,849,977Liquid Protein Formulations Containing Thiamine202010,842,753Modified alginates for cell encapsulation and cell therapy202010,844,028Aminoalcohol lipidoids and uses thereof202010,835,486Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates202010,821,183Liquid protein formulations containing 4-(3-butyl-1-imidazolio)-1-butane sulfonate (BIM)202010,821,184Liquid protein formulations containing thiamine pyrophosphate (TPP)202010,814,115Microneedle devices and uses thereof202010,786,446Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates202010,736,848Vaccine nanotechnology202010,736,966Brush-poly (glycoamidoamine)-lipids and uses thereof202010,729,818Modified alginates for anti-fibrotic materials and applications202010,730,983Biocompatible coatings and hydrogels for reducing foreign body response and fibrosis202010,716,752Residence structures and related methods202010,716,751Residence structures and related methods202010,709,818Modified alginates for anti-fibrotic materials and applications202010,709,667Hydrogel encapsulated cells and anti-inflammatory drugs202010,696,944Intracellular delivery202010,683,379Polymers, hydrogels, and uses thereof202010,682,260Quick-release adhesive tapes202010,682,374Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof202010,675,351Nanostructured gels capable of controlled release of encapsulated agents202010,646,571Liquid protein formulations containing cimetidine202010,610,482Residence structures and related methods202010,596,110Residence structures and related methods202010,596,267Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of drug compounds to the inner ear for treatment of auditory disease202010,568,883Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss202010,548,959Compositions and methods for modified dendrimer nanoparticle delivery202010,548,844pH-responsive mucoadhesive polymeric encapsulated microorganisms202010,532,027Residence structures and related methods202010,526,573Disruption and field enabled delivery of compounds and compositions into cells202010,517,820Residence structures and related methods201910,517,819Residence structures and related methods201910,485,861Nanoparticle-based compositions201910,426,735Modified alginates for anti-fibrotic materials and applications201910,413,507Enteric elastomers201910,369,255Scaffolds comprising nanoelectronic components for cells, tissues, and other applications201910,347,875Safely ingestible batteries and methods201910,314,917Targeted polymeric inflammation-resolving nanoparticles201910,300,136Micromolded or 3-D printed pulsatile release vaccine formulations201910,292,936Modified alginates for cell encapsulation and cell therapy201910,285,949Modified alginates for cell encapsulation and cell therapy201910,278,922Hydrogel encapsulated cells and anti-inflammatory drugs201910,201,655Methods and devices for inserting a needle201910,189,802Aminoalcohol lipidoids and uses thereof201910,182,985Residence structures and related methods201910,179,195Method comprising contacting tissue with a cross-linkable polyester prepolymer201910,179,172Liquid pharmaceutical formulations for injection comprising yellow 5 or orange G and uses thereof201910,172,791Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates201910,149,635Ingestible devices and methods for physiological status monitoring201810,124,336Selective delivery of material to cells201810,117,934Conjugated lipomers and uses thereof201810,106,832Method for manufacturing a microbial detection device, microbial detection method, microbial detection kit, and microbial detection device201810,086,013Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof201810,041,046Compositions and methods for epithelial stem cell expansion and culture201810,041,047Compositions and methods for epithelial stem cell expansion and culture201810,035,871Urethane-crosslinked biodegradable elastomers201810,011,817Cell rolling separation20189,994,615Self-regulated peptide hydrogel for insulin delivery20189,981,068Polymers which resist bacterial attachment20189,974,859Nanostructured gels capable of controlled release of entrapped agents20189,972,649Nanowire FET imaging system and related techniques20189,970,002Compositions and methods for functional nucleic acid delivery20189,931,477Methods and devices for sensing tissues and tissue compartments20189,931,410Nanoparticles for targeted delivery of multiple therapeutic agents and methods of use20189,925,263'Liquid pharmaceutical formulations for injection comprising procaine and uses thereof'20189,913,905'Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof'20189,907,704'Quick-release adhesive tapes'20189,895,443'Multi-tailed lipids and uses thereof'20189,872,911Alpha-aminoamidine polymers and uses thereof20189,876,080Strained group IV channels20189,867,781'Hydrogel encapsulated cells and anti-inflammatory drugs'20189,867,869'Insulin derivatives for diabetes treatment'20189,833,513Liquid protein formulations for injection comprising 1-butyl-3-methylimidazolium methanesulfonate and uses thereof20179,775,551'Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications'20179,741,975'Safely ingestible batteries'20179,724,447'Hydrophobic tissue adhesives'20179,700,627'Biodegradable poly (beta-amino esters) and uses thereof'20179,689,854'Food safety detection device and manufacturing method for the same'20179,688,812'Polymers for functional particles'20179,682,169'Hydrogels for vocal cord and soft tissue augmentation and repair'20179,649,391'Particles with multiple functionalized surface domains'20179,649,279'Fortified micronutrient salt formulations'20179,614,082'Al-poor barrier for InGaAs semiconductor structure'20179,612,203'Detection device and manufacturing method for the same'20179,556,110'Aminoalcohol lipidoids and uses thereof'20179,555,007'Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates'20179,555,413'Cell rolling separation'20179,549,901'Lipid-polymer hybrid particles'20179,539,210'Vaccine nanotechnology'20179,532,956'PH sensitive biodegradable polymeric particles for drug delivery'20179,526,702'Vaccine nanotechnology'20169,512,073'Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof'20169,492,400'Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals'20169,474,717'Vaccine nanotechnology'20169,457,047'Immunomodulating compositions and methods of use thereof'20169,457,128'Scaffolds comprising nanoelectronic components for cells, tissues, and other applications'20169,458,357'ph-sensitive sacrificial materials for the microfabrication of structures'20169,439,859'Adjuvant incorporation in immunoanotherapeutics'20169,439,968'Amine-containing lipidoids and uses thereof'20169,440,008'Methods and compositions for the treatment of open and closed wound spinal cord injuries'20169,422,373'Modified alginates for cell encapsulation and cell therapy'20169,381,477'Microfluidic synthesis of organic nanoparticles'20169,339,529'Glucose-responsive microgels for closed loop insulin delivery'20169,332,991'Adhesive articles containing a combination of surface micropatterning and reactive chemistry and methods of making and using thereof'20169,333,163'Particles with multiple functionalized surface domains'20169,333,179'Amphiphilic compound assisted nanoparticles for targeted delivery'20169,315,472'1,3,5-triazinane-2,4,6-trione derivatives and uses thereof'20169,308,280'Targeting of antigen presenting cells with immunonanotherapeutics'20169,301,926'Local drug delivery devices and methods for treating cancer'20169,267,937'System for screening particles'20169,238,716'Conjugated lipomers and uses thereof'20169,236,556'Polymer composite actuator and generator driven by water gradients'20169,233,072'Adjuvant incorporation in immunonanotherapeutics'20169,227,917'Amine-containing lipidoids and uses thereof'20169,217,129'Oscillating cell culture bioreactor'20159,216,188'Hydrogels for vocal cord and soft tissue augmentation and repair'20159,198,568'Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production'20159,193,827'Poly(beta-amino alcohols), their preparation, and uses thereof'20159,186,640'Delivery and controlled release of encapsulated lipophilic nutrients'20159,173,732'Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord'20159,168,389'Harmonic generation for activation of species and/or delivery of species to a target environment'20159,114,009'Nanowired three dimensional tissue scaffolds'20159,101,666'Biodegradable poly(beta-amino esters) and uses thereof'20159,101,695'Methods and compositions for the treatment of open and closed wound spinal cord injuries'20159,080,014'Polymers for functional particles'20159,060,842'Adhesive articles'20159,063,128'Three dimensional lignocellulosic detection device'20159,011,751'Highly convertible endolumenal prostheses and methods of manufacture'20159,006,487'Amine-containing lipids and uses thereof'20158,986,988'Cell rolling separation'20158,969,353'Aminoalcohol lipidoids and uses thereof'20158,932,595'Nicotine immunonanotherapeutics'20158,920,388'Methods and devices for sensing tissues and tissue compartments'20148,912,304'Polyol-based polymers'20148,906,381'Immunonanotherapeutics that provide IGG humoral response without T-cell antigen'20148,858,966'Methods and compositions for the treatment of open and closed wound spinal cord injuries'20148,834,522'Biodegradable shape memory polymeric sutures'20148,822,410'Tympanic membrane permeating ear drops and uses thereof'20148,808,681'Crosslinked, degradable polymers and uses thereof'20148,802,153'System for targeted delivery of therapeutic agents'20148,709,483'System for targeted delivery of therapeutic agents'20148,691,203'Method comprising contacting tissue with a cross-linkable polyester prepolymer'20148,685,434'Methods and compositions for the treatment of open and closed wound spinal cord injuries'20148,642,333'Particulate delivery vehicles for embryoid bodies'20148,637,028'Adjuvant incorporation in immunonanotherapeutics'20148,591,905'Nicotine immunonanotherapeutics'20138,580,253'Immunomodulating compositions and methods of use'20138,562,966'End-modified poly(beta-amino esters) and uses thereof'20138,562,998'Targeting of antigen presenting cells with immunonanotherapeutics'20138,557,231'Biodegradable poly(beta-amino esters) and uses thereof'20138,450,298'Aminoalcohol lipidoids and uses thereof'20138,442,611'Medical device with reservoir-based sensors'20138,403,907'Method for wirelessly monitoring implanted medical device'20138,394,410'Soft polylactides'20138,377,463'Methods and compositions for the treatment of open and closed wound spinal cord injuries'20138,372,325'Highly convertible endolumenal prostheses and methods of manufacture'20138,367,410'Application of electrical stimulation for functional tissue engineering in vitro and in vivo'20138,367,113'Polymers for functional particles'20138,343,497'Targeting of antigen presenting cells with immunonanotherapeutics'20138,343,498'Adjuvant incorporation in immunonanotherapeutics'20138,323,698'Polymers for functional particles'20128,308,707'Method and system for drug delivery to the eye'20128,303,625'Biodegradable shape memory polymeric sutures'20128,287,849'Biodegradable poly(beta-amino esters) and uses thereof'20128,277,812'Immunonanotherapeutics that provide IgG humoral response without T-cell antigen'2012RE043612'Biodegradable poly(β-amino esters) and uses thereof'20128,198,628'Doped substrate to be heated'20128,193,334'Polymer-encapsulated reverse micelles'20128,143,042'Biodegradable elastomers'20128,143,368'Disposable medical supplies from hydrolytically biodegradable plastics'20128,110,213'Method of forming a tissue structure by introducing cells into an implanted matrix'20128,071,082'End-modified poly(beta-amino esters) and uses thereof'20117,943,179'pH triggerable polymeric particles'20117,918,842'Medical device with controlled reservoir opening'20117,914,579'Tissue engineered tendons and ligaments'20117,901,397'Method for operating microchip reservoir device'20117,892,221'Method of controlled drug delivery from implant device'20117,883,718'Methods and devices for the sustained release of multiple drugs'20117,879,019'Method of opening reservoir of containment device'2011RE042072'Compositions and methods for enhancing receptor-mediated cellular internalization'2011RE042012'Compositions and methods for enhancing receptor-mediated cellular internalization'2010RE041996'Composition and methods for enhancing receptor-mediated cellular internalization'20107,838,024'Methods and devices for the sustained release of multiple drugs'20107,833,545'Methods and devices for the sustained release of multiple drugs'20107,829,112'Methods and devices for the sustained release of multiple drugs'20107,776,024'Method of actuating implanted medical device'2010RE041461'Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum'20107,727,969'Controlled release nanoparticle having bound oligonucleotide for targeted delivery'20107,722,894'Biodegradable polymer'2010RE041328'Purification of Heparinase I, II and III from Flavobacterium heparinum '20107,648,739'Switchable surfaces'20107,648,677'Method for operating a reservoir-based sensor device'20107,628,977'Particles for inhalation having sustained release properties'20097,625,580'Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering'20097,614,135'Method for making reservoir-based sensor device'20097,550,441'Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting'20097,462,471'Porous biodegradable polymeric materials for cell transplantation'20087,452,785'Method of fabrication of highly heat dissipative substrates'20087,435,408'Porous particles comprising excipients for deep lung delivery'20087,427,394'Biodegradable poly(β-amino esters) and uses thereof'20087,410,616'Device for the controlled exposure of reservoir-based sensors'20087,377,939'Highly convertible endolumenal prostheses and methods of manufacture'20087,354,597'Microscale lyophilization and drying methods for the stabilization of molecules'20087,291,693'Bioerodible conducting materials'20077,252,982'Tissue engineering enhanced by the transfer of a growth factor gene'20077,226,442'Microchip reservoir devices using wireless transmission of power and data'20077,112,361'Methods of making decomposable thin films of polyelectrolytes and uses thereof'20067,097,855'Transdermal thermal polymerization'20067,077,866'Resorbable interbody spinal fusion devices'20067,070,590'Microchip drug delivery devices'20067,070,592'Medical device with array of electrode-containing reservoirs'20067,052,678'Particles for inhalation having sustained release properties'20067,020,355'Switchable surfaces'20066,998,115'Biodegradable poly(β-amino esters) and uses thereof'20066,977,223'Three dimensional microfabrication'20056,977,138'Reactive polymer coatings'20056,976,982'Flexible microchip devices for ophthalmic and other applications'20056,977,087'Aerodynamically light particles for pulmonary drug delivery'20056,942,868'Aerodynamically light particles for pulmonary drug delivery'20056,855,329'Surface coating spatially controlled patterns'20056,849,463'Microfabricated devices for the storage and selective exposure of chemicals and devices'20056,849,272'Endosomolytic agents and cell delivery systems'20056,840,962'Tissue engineered tendons and ligaments'20056,808,522'Microchip devices for delivery of molecules and methods of fabrication thereof'20046,800,296'Modification of surfaces using biological recognition events'20046,740,310'Porous particles comprising excipients for deep lung delivery'20046,720,402'Shape memory polymers'20046,699,470'Mesh-gel constructs for cell delivery containing enzymes and/or enzyme inhibitors to control gel degradation'20046,699,505'Method of increasing the efficacy of antibiotics by compexing with cyclodextrins'20046,692,911'Cell delivery compositions'20046,689,608'Porous biodegradable polymeric materials for cell transplantation'20046,653,283'Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis'20036,652,837'Preparation of novel particles for inhalation'20036,635,283'Aerodynamically light particles for pulmonary drug delivery'20036,582,717'Drug delivery composition and device'20036,582,960'Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering'20036,569,654'Electroactive materials for stimulation of biological activity of stem cells'20036,551,838'Microfabricated devices for the storage and selective exposure of chemicals and devices'20036,548,002'Method of making a biodegradable interbody spinal fusion devices'20036,537,567'Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells'20036,537,256'Microfabricated devices for the delivery of molecules into a carrier fluid'20036,503,480'Aerodynamically light particles for pulmonary drug delivery'20036,491,666'Microfabricated devices for the delivery of molecules into a carrier fluid'20026,471,993'Three-dimensional polymer matrices'20026,447,752'Amorphous porous particles for deep lung delivery'20026,447,753'Porous particles for deep lung delivery'20026,436,443'Porous particles comprising excipients for deep lung delivery'20026,426,339'Formulations and methods for providing prolonged local anesthesia'20026,419,945'Buffered resorbable internal fixation devices and methods for making material therefore'20026,403,558'Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis'20026,399,102'Aerodynamically light particles for pulmonary drug delivery'20026,388,043'Shape memory polymers'20026,387,397'Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery'20026,355,224'Conductive polymer contrast agent compositions and uses therefor'20026,326,020'Local anesthetic formulations'20016,309,635'Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo'20016,306,819'Method for regulating size of vascularized normal tissue'2001RE037410'Controlled local delivery of chemotherapeutic agents for treating solid tumors'20016,281,015'Localized delivery of factors enhancing survival of transplanted cells'20016,262,183'Hydroxamic acid polymers formed from primary amide polymers'20016,254,890'Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids'20016,254,854'Porous particles for deep lung delivery'20016,241,771'Resorbable interbody spinal fusion devices'20016,238,702'High load formulations and methods for providing prolonged local anesthesia'20016,224,893'Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering'20016,217,863'Rationally designed polysaccharide lyases derived from heparinase I'20016,214,387'Biodegradable polymer matrices for sustained delivery of local anesthetic agents'20016,197,229'Method for high supercoiled DNA content microspheres'20016,190,893'Electroactive materials for stimulation of biological activity of bone marrow stromal cells'20016,190,315'Sonophoretic enhanced transdermal transport'2001RE037053'Particles incorporating surfactants for pulmonary drug delivery'20016,174,952'Monolithic polymer composition having a water absorption material'20016,160,084'Biodegradable shape memory polymers'20006,149,864'Supercritical fluid sterilization method'20006,136,295'Aerodynamically light particles for pulmonary drug delivery'20006,123,727'Tissue engineered tendons and ligaments'20006,123,861'Fabrication of microchip drug delivery devices'20006,095,148'Neuronal stimulation using electrically conducting polymers'20006,060,082'Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery'20006,046,187'Formulations and methods for providing prolonged local anesthesia'20006,041,253'Effect of electric field and ultrasound for transdermal drug delivery'20006,025,331'Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis'20006,018,678'Transdermal protein delivery or measurement using low-frequency sonophoresis'20006,007,845'Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers'19996,004,534'Targeted polymerized liposomes for improved drug delivery'19996,002,961'Transdermal protein delivery using low-frequency sonophoresis'1999Career & activity timeline
Assembled from patent assignee/location history and declaration credentials.
1982–2021Patents assigned to MASSACHUSETTS INST TECHNOLOGY (327)· patent assignee history
1982–2001Based in Somerville, MA, US· patent location history
1982–2020Based in Cambridge, MA, US· patent location history
1988–2019Patents assigned to CHILDRENS MEDICAL CENTER (43)· patent assignee history
1990–2021Based in Newton, MA, US· patent location history
1994–2020Patents assigned to LANGER ROBERT S (60)· patent assignee history
1996–2011Patents assigned to PENN STATE RES FOUND (24)· patent assignee history
2015–2017Based in Hsinchu, TW· patent location history
2016–2021Patents assigned to BRIGHAM & WOMENS HOSPITAL INC (41)· patent assignee history
2017–2020Based in Newtown, MA, US· patent location history
Inventor activity
Assignee and location history derived from the patent record.
Assignees
| Assignee | Patents | Span |
|---|---|---|
| MASSACHUSETTS INST TECHNOLOGY | 327 | 1982–2021 |
| LANGER ROBERT Sself | 60 | 1994–2020 |
| CHILDRENS MEDICAL CENTER | 43 | 1988–2019 |
| BRIGHAM & WOMENS HOSPITAL INC | 41 | 2016–2021 |
| PENN STATE RES FOUND | 24 | 1996–2011 |
Locations
| Location | Patents | Span |
|---|---|---|
| Newton, Massachusetts, US | 348 | 1990–2021 |
| Somerville, Massachusetts, US | 45 | 1982–2001 |
| Cambridge, Massachusetts, US | 8 | 1982–2020 |
| Hsinchu, TW | 3 | 2015–2017 |
| Newtown, Massachusetts, US | 2 | 2017–2020 |