Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death. [structure]

Claims

13 · 3 independent · depth 3

13 granted claims

›1.independentA compound of formula (I)+10

›2.↳ 1The compound of claim 1,nwhereinR1/R2 are independently from each other hydrogen, halogen, hydroxy, 1-3C-alkyl, 1-3C-alkoxy, 1-3C-haloalkyl, or 1-3C-h…d2

›3.↳ 1The compound of claim 1,nwhereinR1/R2 are independently from each other hydrogen or halogen,R3 is hydrogen or 1-4C-alkoxy,n is 1,R4 isn(a) hydroxy,(b)…d2

›4.↳ 1The compound of claim 1,nwhereinR1/R2 are independently from each other hydrogen or fluorine,R3 is hydrogen, methoxy or ethoxy,n is 1,R4 isn(a) hydrox…d2

›5.↳ 1The compound of claim 1, selected from the group consisting of:d2

›6.↳ 1A process for the manufacture of a compound of formula (I) according to claim 1, wherein R5 is hydrogen, comprising reacting a compound of formula (1-…d2

›7.↳ 1A process for the manufacture of a compound of formula (I) according to claim 1, comprising treating a compound of formula (Ib)d2

›10.↳ 1A method of treatment of a hyperproliferative disease selected from cervical cancer, breast cancer, ovarian cancer, non-small cell lung cancer, prosta…d2+1

›12.↳ 1A pharmaceutical composition comprising at least one compound of claim 1 and at least one pharmaceutically acceptable auxiliary.d2+1

›8.independentAn intermediate compound of general formula (1-3),

›9.independentAn intermediate compound of general formula (1-4),

Classifications

8 codes

IPC · International Patent Classification

Section A — Human necessities

A61K31/506
A61K45/06
A61K31/695
A61K31/5377

Section C — Chemistry; metallurgy

C07D403/04
C07F7/18
C07D401/14
C07D405/14

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File wrapper

Pendency

3.3 y

1,196 days filing → grant

Office actions

non-final + final

Responses

3 RCE

Examiner

Alexander R Pagano

art unit 1624 · TC 1600

Law firm

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Citations: 66 back · 0 forward

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Priority chain

1 priority documents

›Priority documents — 1

Type	Document	Date
related publication	US 20150141372 A1	21 May 2015

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