Pyrrolobenzodiazepines and targeted conjugates
Granted 12 Jul 2016 · 4 office actions
Current assignee: Seagen Inc. · originally AstraZeneca
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Inventors: Patrick Burke, Scott Jeffrey, Philip Wilson Howard · Examiner: Bruck Kifle · AU 1622 · TC 1600
Life of the patent
4 dated eventsAbstract
A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R 10 is H, and R 11 is OH, OR A , where R A is saturated C 1-4 alkyl; (b) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R 10 is H and R 11 is S0 2 M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation. [structure] [structure]
Claims
5 · 2 independent · depth 2Classifications
3 codes- A61K47/48
- C07D471/04
- C07D487/04
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2 priority documents›Priority documents — 2
| Type | Document | Date |
|---|---|---|
| provisional | US 61547192 | 14 Oct 2011 |
| related publication | US 20140286970 A1 | 25 Sep 2014 |
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