The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.

Claims

10 · 2 independent · depth 3

10 granted claims

›1.independentA method of treating an ischemic stress condition in an individual in need thereof, the method comprising administering to the individual an effective…+4

›6.independentA method of treating an ischemic stress condition in an individual in need thereof, the method comprising administering to the individual an effective…+4

Classifications

3 codes

IPC · International Patent Classification

Section A — Human necessities

A61K31/36

Section C — Chemistry; metallurgy

C07D405/12
C07D317/58

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File wrapper

Pendency

1.4 y

497 days filing → grant

Office actions

after a restriction

Responses

no RCE

Examiner

Anna Pagonakis

art unit 1628 · TC 1600

Law firm

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Citations: 143 back · 0 forward

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Priority chain

2 priority documents

Priority

8 Mar 2007

earliest claimed

›Priority documents — 2

Type	Document	Date
provisional	US 60905963	8 Mar 2007
related publication	US 20150105456 A1	16 Apr 2015

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