Indole carboxamide derivative

The compound or a salt thereof according to claim 1, whereinnR1 is H, halogen, or lower alkyl which may be substituted with one or more substituents selected from the group consisting of halogen, —O-lower alkyl, and —O-halogeno-lower alkyl,R3 and R4 are the same as or different from each other and are H, halogen, or lower alkyl which may be substituted with one or more substituents selected from the group consisting of halogen, —O-lower alkyl, and —O-halogeno-lower alkyl,R51 and R52 are the same as or different from each other and are each H, lower alkyl which may be substituted with one or more substituents selected from Group G21, cycloalkyl which may be substituted with one or more substituents selected from Group G11, wherein Group G11 is lower alkyl, halogeno-lower alkyl, halogen, —OH, and —O-lower alkyl, and Group G21 is halogen, —OH, —O-lower alkyl, —O-halogeno-lower alkyl, and NR9R10,R6 is lower alkyl which may be substituted with one or more substituents selected from Group G41, or cycloalkyl which may be substituted with one or more substituents selected from Group G31, wherein Group G31 is lower alkyl, halogeno-lower alkyl, halogen, —OH, and —O-lower alkyl, and Group G41 is halogen, —OH, —O-lower alkyl, —O-halogeno-lower alkyl, and cycloalkyl, andR7 and R8 are the same as or different from each other and are lower alkyl or H.

The compound or a salt thereof according to claim 1, wherein Y is CR1, R1 is H, and X is a bond.

The compound or a salt thereof according to claim 1, wherein Y is CR1, R1 is H, and X is —NH—.

The compound or a salt thereof according to claim 1, wherein Y is N and X is a bond.

The compound or a salt thereof according to claim 1, wherein Y is N and X is —NH—.

The compound or a salt thereof according to claim 1, wherein the compound is selected from the group consisting of:n3-(2-acetamidoethyl)-5-methoxy-N-methyl-1H-indole-2-carboxamide,3-{2-[(difluoroacetyl)amino]ethyl}-5-methoxy-N-methyl-1H-indole-2-carboxamide,3-{2-[(difluoroacetyl)amino]ethyl}-6-fluoro-5-methoxy-N-methyl-1H-indole-2-carboxamide,3-(2-acetamidoethyl)-6-fluoro-5-methoxy-N-methyl-1H-indole-2-carboxamide, and5-methoxy-N-methyl-3-{2-[(methylcarbamoyl)amino]ethyl}-1H-indole-2-carboxamide.

A pharmaceutical composition comprising the compound or a salt thereof according to claim 1, and a pharmaceutically acceptable excipient.

A method for preventing or treating urinary incontinence, comprising administering to a subject an effective amount of the compound or a salt thereof according to claim 1.