A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.

Claims

49 · 2 independent · depth 3

49 granted claims

›1.independentA method for treating damaged cardiac tissue using sub-atmospheric pressure, comprising:ni. placing a porous material proximate the damaged cardiac ti…+46

›2.↳ 1The method for treating damaged cardiac tissue according to claim 1, wherein the porous material comprises a bio-incorporable material.d2+1

›4.↳ 1The method for treating damaged cardiac tissue according to claim 1, wherein the porous material comprises a polyethylene, polyurethane, polyester mat…d2

›5.↳ 1The method for treating damaged cardiac tissue according to claim 1, wherein the step of placing a porous material proximate the damaged cardiac tissu…d2

›8.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises myocardial, peripheral muscle cells, o…d2

›9.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of operably connecting a vacuum source comprises connecting…d2

›10.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of placing a porous material proximate the damaged cardiac …d2+1

›12.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of placing a porous material proximate the damaged cardiac …d2+1

›14.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises a vacuum port for receiving sub-atmospheric pres…d2

›15.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of sealing the cover to tissue surrounding the damaged card…d2

›16.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of locating a cover comprises locating a self-adhesive shee…d2

›17.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises an electrospun material.d2+4

›18.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises a cast material.d2

›19.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises collagen.d2+1

›21.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises a diol citrate.d2

›23.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises poly 1,8-octanediol citrate.d2

›25.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises chitosan.d2

›27.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the cover comprises polylactic acid.d2

›29.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising maintaining the sub-atmospheric pressure at the damaged cardiac t…d2

›30.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising maintaining the sub-atmospheric pressure at the damaged cardiac t…d2

›31.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising maintaining a sub-atmospheric pressure of about 25 mm Hg below at…d2

›32.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising maintaining sub-atmospheric pressure of between about 25 and 125 …d2

›33.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the step of placing a porous material comprises placing a porous mat…d2+1

›35.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises collagen.d2

›36.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises chitosan.d2

›37.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises polycaprolactone.d2

›38.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises a polyglycolic, polylactic acid, or co…d2

›39.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises a porous, open-cell collagen material.d2

›40.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises a porous synthetic polymer material.d2

›41.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises at least one of a porous sheet and a f…d2

›42.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises two or more layers, with the layer clo…d2+1

›44.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises pores sufficiently small at the interf…d2

›45.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material comprises a pore size large enough to allow move…d2

›46.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, wherein the porous material is sealed to prevent the transmission of sub-atm…d2

›47.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising infusing peripheral muscle cells into the damaged cardiac tissue.d2

›48.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising infusing myocardial cells into the damaged cardiac tissue.d2

›49.↳ 1multiple · 1, 6The method for treating damaged cardiac tissue according to claim 1 or 6, comprising infusing pleuripotent progenitor cells into the damaged cardiac t…d2

›6.independentA method for treating damaged cardiac tissue using sub-atmospheric pressure, comprising:ni. placing a porous bio-incorporable material proximate the d…+1

Classifications

4 codes

IPC · International Patent Classification

Section A — Human necessities

A61B19/00
A61B17/00
A61B17/08
A61B17/30

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Pendency

6.2 y

2,252 days filing → grant

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Responses

4 RCE

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Examiner

Nicholas Lucchesi

art unit 3763 · TC 3700

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Citations: 1,627 back · 1 forward

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Priority chain

2 priority documents

Priority

13 Aug 2008

earliest claimed

›Priority documents — 2

Type	Document	Date
provisional	US 61088558	13 Aug 2008
related publication	US 20100121229 A1	13 May 2010

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