Drug evaluation method and drug evaluation device

A drug evaluation method for evaluating crystallinity of a drug suspended in a liquid, the method comprising:nobtaining by an attenuated reflection method using a terahertz wave an evaluation absorption spectrum for a frequency concerning the liquid to be evaluated; anddetermining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum,wherein a ratio of the crystalline particle suspended in the liquid is determined according to the area of the absorption peak in the evaluation absorption spectrum.

A drug evaluation method for evaluating crystallinity of a drug suspended in a liquid, the method comprising:nobtaining by an attenuated reflection method using a terahertz wave an evaluation absorption spectrum for a frequency concerning the liquid to be evaluated; anddetermining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum,wherein a reference absorption spectrum for a frequency concerning a liquid serving as a reference is obtained by an attenuated reflection method using a terahertz wave; andwherein whether or not there is an amorphous particle suspended in the liquid is determined according to whether or not a baseline of the evaluation absorption spectrum changes from a baseline of the reference absorption spectrum.

A drug evaluation method for evaluating crystallinity of a drug suspended in a liquid, the method comprising:nobtaining by an attenuated reflection method using a terahertz wave an evaluation absorption spectrum for a frequency concerning the liquid to be evaluated; anddetermining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum,wherein a reference absorption spectrum for a frequency concerning a liquid serving as a reference is obtained by an attenuated reflection method using a terahertz wave; andwherein whether or not there are crystalline and amorphous particles suspended in the liquid is determined according to whether or not a baseline of the evaluation absorption spectrum changes from a baseline of the reference absorption spectrum.

A drug evaluation method for evaluating crystallinity of a drug suspended in a liquid, the method comprising:nobtaining by an attenuated reflection method using a terahertz wave an evaluation absorption spectrum for a frequency concerning the liquid to be evaluated; anddetermining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum,wherein a crystal form of the crystalline particle suspended in the liquid is determined according to a frequency of the absorption peak in the evaluation absorption spectrum.

A drug evaluation device for evaluating crystallinity of a drug suspended in a liquid, the device comprising:na light source for emitting laser light;a separating unit for separating the laser light emitted from the light source into puma light and probe light;a terahertz wave generator for generating a terahertz wave in response to the pump light incident thereon after being separated by the separating unit;an internal total reflection prism, having entrance and exit surfaces for the terahertz wave, for propagating therethrough the terahertz wave incident thereon from the entrance surface and totally reflecting the terahertz wave at a reflection surface so that the terahertz wave exits from the exit surface;a terahertz wave detector for receiving the terahertz wave emitted from the exit surface of the internal total reflection prism and the probe light separated by the separating unit and detecting a correlation between the terahertz wave and the probe light;a data acquiring unit, for acquiring an evaluation absorption spectrum for a frequency concerning the liquid arranged on the reflection surface of the internal total reflection prism, by an evanescent component of the terahertz occurring when the terahertz wave is totally reflected; anda data analyzer for determining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum acquired by the data acquiring unit,wherein the data analyzer determines a ratio of the crystalline particle suspended in the liquid according to the area of the absorption peak in the evaluation absorption spectrum.

A drug evaluation device for evaluating crystallinity of a drug suspended in a liquid, the device comprising:na light source for emitting laser light;a separating unit for separating the laser light emitted from the light source into pump light and probe light;a terahertz wave generator for generating a terahertz wave in response to the pump light incident thereon after being separated by the separating unit;an internal total reflection prism, having entrance and exit surfaces for the terahertz wave, for propagating therethrough the terahertz wave incident thereon from the entrance surface and totally reflecting the terahertz wave at a reflection surface so that the terahertz wave exits from the exit surface;a terahertz wave detector for receiving the terahertz wave emitted from the exit surface of the internal total reflection prism and the probe light separated by the separating unit and detecting a correlation between the terahertz wave and the probe light;a data acquiring unit, for acquiring an evaluation absorption spectrum for a frequency concerning the liquid arranged on the reflection surface of the internal total reflection prism, by an evanescent component of the terahertz occurring when the terahertz wave is totally reflected; anda data analyzer for determining whether or not there is a crystalline article suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum acquired by the data acquiring unit,wherein the data analyzer has a reference absorption spectrum for a frequency concerning a liquid serving as a reference and determines whether or not there is an amorphous particle suspended in the liquid according to whether or not a baseline of the evaluation absorption spectrum changes from a baseline of the reference absorption spectrum.

A drug evaluation device for evaluating crystallinity of a drug suspended in a liquid, the device comprising:na light source for emitting laser light;a separating unit for separating the laser light emitted from the light source into pump light and probe light;a terahertz wave generator for generating a terahertz wave in response to the pump light incident thereon after being separated by the separating unit;an internal total reflection prism, having entrance and exit surfaces for the terahertz wave, for propagating therethrough the terahertz wave incident thereon from the entrance surface and totally reflecting the terahertz wave at a reflection surface so that the terahertz wave exits from the exit surface;a terahertz wave detector for receiving the terahertz wave emitted from the exit surface of the internal total reflection prism and the probe light separated by the separating unit and detecting a correlation between the terahertz wave and the probe light;a data acquiring unit, for acquiring an evaluation absorption spectrum for a frequency concerning the liquid arranged on the reflection surface of the internal total reflection prism, by an evanescent component of the terahertz occurring when the terahertz wave is totally reflected; anda data analyzer for determining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum acquired by the data acquiring unit,wherein the data analyzer has a reference absorption spectrum for a frequency concerning a liquid serving as a reference and determines whether or not there is an amorphous particle suspended in the liquid according to whether or not a baseline of the evaluation absorption spectrum changes from a baseline of the reference absorption spectrum.

A drug evaluation device for evaluating crystallinity of a drug suspended in a liquid, the device comprising:na light source for emitting laser light;a separating unit for separating the laser light emitted from the light source into pump light and probe light;a terahertz wave generator for generating a terahertz wave in response to the pump light incident thereon after being separated by the separating unit;an internal total reflection prism, having entrance and exit surfaces for the terahertz wave, for propagating therethrough the terahertz wave incident thereon from the entrance surface and totally reflecting the terahertz wave at a reflection surface so that the terahertz wave exits from the exit surface;a terahertz wave detector for receiving the terahertz wave emitted from the exit surface of the internal total reflection prism and the probe light separated by the separating unit and detecting a correlation between the terahertz wave and the probe light;a data acquiring unit, for acquiring an evaluation absorption spectrum for a frequency concerning the liquid arranged on the reflection surface of the internal total reflection prism, by an evanescent component of the terahertz occurring when the terahertz wave is totally reflected; anda data analyzer for determining whether or not there is a crystalline particle suspended in the liquid according to whether or not an absorption peak exists in the evaluation absorption spectrum acquired by the data acquiring unit,wherein the data analyzer determines a crystal form of the crystalline particle suspended in the liquid according to a frequency of the absorption peak in the evaluation absorption spectrum.