Disclosed herein are compounds exemplified by the following structure Formula (I) [structure] that form covalent bonds with Bruton\'s tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds of Formula (I). Methods of using the Btk inhibitors exemplified by the structure of Formula (I) are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Claims

24 · 1 independent · depth 10

24 granted claims

›1.independentA compound having the structure of Formula (I):+23

›2.↳ 1The compound of claim 1, wherein G is Laâ€”Ar.d2+19

›3.↳ 2The compound of claim 2, wherein La is â€”Oâ€”; and Ar is phenyl.d3+18

›4.↳ 3The compound of claim 3, wherein Y is C2-C7heterocycloalkylene.d4+8

›5.↳ 4The compound of claim 4, wherein Z is â€”C(â• O).d5+7

›13.↳ 3The compound of claim 3, wherein Y is phenyl.d4+8

›14.↳ 13The compound of claim 13, wherein Z is C(â• O), NHC(â• O), or N(CH3)C(â• O).d5+7

›22.↳ 1The compound of claim 1, wherein n is 0.d2

›23.↳ 1The compound of claim 1, wherein R1 is â€”F, â€”Cl, â€”CH3, or â€”OCH3.d2

›24.↳ 1A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound claim 1, or a pharmaceutically acceptable salt, or phar…d2

Classifications

4 codes

IPC · International Patent Classification

Section A — Human necessities

A61K31/519
A01N43/90

Section C — Chemistry; metallurgy

C07D487/04
C07D487/00

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File wrapper

Pendency

1.6 y

585 days filing → grant

Office actions

non-final + final

Responses

no RCE

Examiner

Jeffrey H Murray

art unit 1624 · TC 1600

Law firm

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Citations: 221 back · 0 forward

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Priority chain

2 priority documents

Priority

15 Nov 2012

earliest claimed

›Priority documents — 2

Type	Document	Date
provisional	US 61727031	15 Nov 2012
related publication	US 20140142126 A1	22 May 2014

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