In accordance with certain embodiments of the present disclosure, a process of forming a prosthetic device is provided. The process includes forming a dispersion of polymeric nanofibers, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs. A tubular frame is positioned over a tubular polymeric structure. Nanofibers from the dispersion are electrospun onto the tubular frame to form a prosthetic device. The prosthetic device is heated.

Claims

37 · 2 independent · depth 3

37 granted claims

›1.independentA composite structure comprising a tubular frame and comprising a tubular polymeric inner surface and a tubular polymeric outer surface, wherein at le…+19

›2.↳ 1The composite structure of claim 1, wherein both the tubular polymeric inner surface and tubular polymeric outer surface comprise a plurality of elect…d2

›3.↳ 1The composite structure of claim 1, further comprising one or more additional layers of polymeric material.d2+4

›8.↳ 1The composite structure of claim 1, wherein one of the tubular polymeric inner surface and tubular polymeric outer surface comprises nylon, polyuretha…d2

›9.↳ 1The composite structure of claim 1, wherein the tubular polymeric inner surface and a tubular polymeric outer surface have different pore sizes.d2

›10.↳ 1The composite structure of claim 1, wherein the tubular frame comprises a metal.d2

›11.↳ 1The composite structure of claim 1, wherein the tubular frame comprises stainless steel, platinum, gold, titanium, polymer, or nitinol.d2

›12.↳ 1The composite structure of claim 1, wherein the tubular frame comprises a stent.d2

›13.↳ 1The composite structure of claim 1, further comprising a bioactive agent.d2+1

›15.↳ 1The composite structure of claim 1, wherein each of the inner surface and outer surface comprise at least one electrospun layer of a plurality of elec…d2+3

›19.↳ 1The composite structure of claim 1, wherein the composite structure is comprised primarily of micron and sub-micron sized electrostatically spun PTFE …d2

›20.↳ 1The composite structure of claim 1, wherein the tubular polymeric inner surface comprises a plurality of electrospun poly(tetrafluoroethylene) (PTFE) …d2

›21.independentA composite structure comprising a tubular frame and comprising at least three tubular polymeric layers associated therewith, wherein one tubular poly…+16

›22.↳ 21The composite structure of claim 21, wherein at least two of the tubular polymeric layers comprise a plurality of electrospun PTFE nanofibers.d2

›23.↳ 21The composite structure of claim 21, wherein at least one of the three tubular polymeric layers is positioned to form the inner surface of the composi…d2

›24.↳ 21The composite structure of claim 21, wherein at least one of the tubular polymeric layers comprises nylon, polyurethane, polyester, fluorinated ethyle…d2

›25.↳ 21The composite structure of claim 21, wherein at least one of the tubular polymeric layer positioned to form the inner surface of the composite structu…d2

›26.↳ 21The composite structure of claim 21, wherein the tubular polymeric layer positioned to form the inner surface of the composite structure and the tubul…d2

›27.↳ 21The composite structure of claim 21, wherein the tubular frame comprises a metal.d2

›28.↳ 21The composite structure of claim 21, wherein the tubular frame comprises stainless steel, platinum, gold, titanium, polymer, or nitinol.d2

›29.↳ 21The composite structure of claim 21, wherein the tubular frame comprises a stent.d2

›30.↳ 21The structure of claim 21, further comprising a bioactive agent.d2+1

›32.↳ 21The composite structure of claim 21, wherein each of the inner surface and outer surface comprise at least one electrospun layer of a plurality of ele…d2+3

›36.↳ 21The composite structure of claim 21, wherein the composite structure is comprised primarily of micron and sub-micron sized electrostatically spun PTFE…d2

›37.↳ 21The composite structure of claim 21, wherein the tubular polymeric layer positioned to form the inner surface comprises a plurality of electrospun pol…d2

Classifications

13 codes

IPC · International Patent Classification

Section A — Human necessities

A61L31/12
A61L27/26
A61F2/82
A61L27/50
A61L31/06
A61F2/06

Section B — Performing operations; transporting

B29C47/06
B01D39/16
B82Y5/00

Section D — Textiles; paper

D01F6/12
D01D5/00

USPC · US Patent Classification

623/1.42264/465

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2.7 y

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Examiner

David Isabella

art unit 3774 · TC 3700

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Priority chain

2 priority documents

Priority

7 Aug 2009

earliest claimed

›Priority documents — 2

Type	Document	Date
provisional	US 61232252	7 Aug 2009
related publication	US 20130053948 A1	28 Feb 2013

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