Methods of manufacture and use of endoluminal devices

An embolic protection filter, comprising:na unibody and seamless frame that includes a support member and a plurality of struts that extend in a generally proximal direction from the support member to a connecting member that is coupled to a guide wire;a filter media that includes a base portion and a closed tapered portion, the base portion defining an open proximal end of the filter media and extending in a generally distal direction from the support member, wherein the closed tapered portion of the filter media is inverted toward the open proximal end of the filter media, and wherein an end region of the closed tapered portion of the filter media is located proximal of the open proximal end of the filter media.

A method of removing embolic debris from a vessel of a patient, comprising:ndeploying a thrombectomy device distal of a thrombus in the vessel of the patient, the thrombectomy device comprising a filter media and a unibody and seamless frame that includes a support member and a plurality of struts that extend in a generally proximal direction from the support member to a connecting member that is coupled to a guide wire, wherein the filter media extends in a generally distal direction from the support member;providing a proximally directed force at the guide wire to cause the frame of the thrombectomy device to be pulled at least partially through the thrombus, wherein the support member is adapted to shear thrombatic material of the thrombus as the frame of the thrombectomy device is pulled at least partially through the thrombus, and wherein the filter media is adapted to capture the thrombatic material.

A thrombectomy device, comprising:na unibody and seamless frame that includes a support member and a plurality of struts that extend in a generally proximal direction from the support member to a connecting member that is coupled to a guide wire;a filter media that extends in a generally distal direction from the support member, the filter media being adapted to permit blood to pass through the filter media and to capture embolic debris carried by the blood;wherein the support member includes a sharp edge that is adapted to shear an intraluminal thrombus as the thrombectomy device is pulled through an area of a blood vessel that includes the intraluminal thrombus, and wherein the filter media is adapted to capture sheared debris from the intraluminal thrombus.