Osteogenic compositions composed of a coprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, the coprecipitate being in divided form, are described. Kits are also described, as are a process for preparing the coprecipitate in divided form, containing at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide.

Claims

46 · 6 independent · depth 5

46 granted claims

›1.independentA coprecipitate comprising at least one complex and at least one insoluble calcium salt, said coprecipitate being in a divided form, said complex bein…+12

›2.↳ 1The coprecipitate as claimed in claim 1, in which the insoluble calcium salt is chosen from the group consisting of calcium orthophosphates in anhydro…d2

›3.↳ 1The coprecipitate as claimed in claim 1, which also comprises at least one insoluble calcium salt chosen from the group consisting of calcium oxalate,…d2

›4.↳ 1The coprecipitate as claimed in claim 1, in which the insoluble calcium salt is chosen from the group consisting of mixed salts formed between cationi…d2

›5.↳ 1The coprecipitate as claimed in claim 1, wherein the complex further includes an additional material with chemo-attracting and angiogenic power select…d2+5

›11.↳ 1The coprecipitate as claimed in claim 1, wherein the dextrans comprising carboxyl functional groups are synthetic dextrans obtained from dextrans on w…d2

›45.↳ 1A process for preparing the coprecipitate as defined in claim 1, which comprises a coprecipitation step obtained by:nprecipitating the complex between…d2+1

›12.independentA coprecipitate comprising at least one complex and at least one insoluble calcium salt, said coprecipitate being in a divided form, said complex bein…

›13.independentA kit for preparing an osteogenic implant, comprising at least:na: a composition comprising at least one osteogenic protein selected from the group co…+27

›14.↳ 13The kit as claimed in claim 13, also comprising an additional composition comprising at least one base.d2+1

›16.↳ 13The kit as claimed in claim 13, in which the composition comprising the osteogenic protein may also comprise the functionalized dextran for forming th…d2

›17.↳ 13The kit as claimed in claim 13, in which the composition comprising the osteogenic protein may also comprise the soluble salt of an anion capable of f…d2

›18.↳ 13The kit as claimed in claim 13, in which the composition comprising the functionalized dextran may also comprise the soluble salt of an anion capable …d2

›19.↳ 13The kit as claimed in claim 13, in which the composition comprising the soluble calcium salt may also comprise a base.d2

›20.↳ 13The kit as claimed in claim 13, in which the soluble calcium salt is chosen from the group consisting of calcium chloride, D-gluconate, formate, D-sac…d2

›21.↳ 13The kit as claimed in claim 13, in which the soluble calcium salt is calcium chloride.d2

›22.↳ 13The kit as claimed in claim 13, in which the soluble salt of an anion capable of forming a precipitate with the calcium ion is a soluble salt whose an…d2

›23.↳ 13The kit as claimed in claim 13, in which the base is chosen from mineral and organic bases.d2+3

›27.↳ 13The kit as claimed in claim 13, which also comprises at least one organic matrix or a mineral matrix or a mixed matrix.d2+5

›33.↳ 13The kit as claimed in claim 13, in which the compositions constituting the kit are aqueous solutions.d2

›34.↳ 13The kit as claimed in claim 13, in which the compositions constituting the kit are lyophilizates.d2+5

›35.↳ 13The kit as claimed in claim 13, wherein the composition a: further comprises an additional composition comprising at least one material with chemo-att…d2

›41.independentA kit comprising:na: a composition comprising at least one osteogenic protein selected from the group consisting of bone morphogenetic proteins and gr…

›42.independentA kit comprising:na: a composition comprising at least one osteogenic protein selected from the group consisting of bone morphogenetic proteins and gr…+1

›44.independentA kit comprising:na: a composition comprising at least one osteogenic protein selected from the group consisting of bone morphogenetic proteins and gr…

Classifications

4 codes

IPC · International Patent Classification

Section A — Human necessities

A61K31/721

Section C — Chemistry; metallurgy

C08B37/02

USPC · US Patent Classification

514/59536/123.12

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Pendency

3.7 y

1,349 days filing → grant

Office actions

non-final + final

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no RCE

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Examiner

Eric S Olson

art unit 1623 · TC 1600

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Priority chain

2 priority documents

Priority

19 Nov 2008

earliest claimed

›Priority documents — 2

Type	Document	Date
provisional	US 61116144	19 Nov 2008
related publication	US 20100166867 A1	1 Jul 2010

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