Protein and production process and use thereof

An isolated nucleic acid molecule encoding a soluble polypeptide consisting of the amino acid sequence of SEQ ID NO: 9.

An isolated nucleic acid molecule consisting of the nucleotide sequence from position 4 to 243 of SEQ ID NO: 3, encoding a soluble polypeptide having an activity of inhibiting angiogenesis and/or an activity of inhibiting bone resorption.

An isolated nucleic acid molecule consisting of a nucleotide sequence encoding a soluble polypeptide having an activity of inhibiting angiogenesis and/or an activity of inhibiting bone resorption, wherein the soluble polypeptide is selected from the group consisting of:n(a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 9, which further has a tag sequence added to the N-terminal or C-terminal thereof consisting of 6 to 8 consecutive histidine residues;(b) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 9, which further has a FLAG tag sequence added to the N-terminal or C-terminal thereof;(c) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 9, which further has tag sequences added to the N-terminal and/or C-terminal thereof consisting of 6 to 8 consecutive histidine residues and a FLAG tag sequence;(d) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 6;(e) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 4.