Pre-mixed, ready-to-use pharmaceutical compositions

A pharmaceutical composition for parenteral administration comprising a pre-mixed aqueous solution comprising:nfrom about 0.1 to 0.4 mg/mL nicardipine or a pharmaceutically acceptable salt thereof;a tonicity agent selected from (i) about 4.5% to about 5% dextrose or (ii) about 0.8% to about 0.9% sodium chloride; anda buffer;the aqueous solution contained in a pharmaceutically acceptable container such that the solution is in contact with non-polar polymers;wherein the composition requires no dilution before administration and has a pH from about 3.6 to about 4.7, the aqueous solution when stored in the container for at least three months at room temperature exhibiting (i) less than a 10% decrease in the concentration of nicardipine or pharmaceutically acceptable salt thereof and (ii) a total impurity formulation of less than about 3%.

A pharmaceutical composition for parenteral administration comprising a pre-mixed aqueous solution comprising:nfrom about 0.1 to 0.4 mg/mL nicardipine or a pharmaceutically acceptable salt thereof;a tonicity agent selected from (i) about 46 to about 50 mg/mL dextrose or (ii) about 8.3 to about 9 mg/mL sodium chloride; anda buffer;from 0 mg/mL to about 4 mg/mL sorbitol;the aqueous solution contained in a pharmaceutically acceptable container such that the solution is in contact with copolyester, polyethylene or polyolefin;wherein the composition requires no dilution before administration and has a pH from about 3.6 to about 4.7, the aqueous solution when stored in the container for at least three months at room temperature exhibiting (i) less than a 10% decrease in the concentration of nicardipine or pharmaceutically acceptable salt thereof and (ii) a total impurity formulation of less than about 3%.