Pyrimidine derivatives for treatment of hyperproliferative disorders

A compound having the structure

A compound selected from the group consisting ofn4-{3-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}-N-methylpyridine-2-carboxamide;4-{3-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridine-2-carboxamide;4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy} pyridine-2-carbonitrile;6-phenyl-N-4-(4-{[2-(trifluoromethyl)pyridin-4-yl] oxy} phenyl)pyrimidine-2,4-diamine;N4-{4-[(2-chloropyridin-4-yl)oxy]phenyl}-6-phenylpyrimidine-2,4-diamine;4-{2-amino-6-[(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)amino]pyrimidin-4-yl}phenyl sulfamate;N-(4-{2-amino-6-[(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)amino]pyrimidin-4-yl}phenyl)glycinamide trifluoroacetate;6-(4-aminophenyl)-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine;6-(6-aminopyridin-3-yl)-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine;6-pyridin-3-yl-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine;N-[(4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy} pyridin-2-yl)methyl]-4-methoxybenzenesulfonamide trifluoroacetate;N-[(4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy} pyridin-2-yl)methyl]methanesulfonamide trifluoroacetate; and(4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridin-2-yl)methanol trifluoroacetate (salt).

A compound of selected from the group consisting ofn(6-(2,6-dimethylphenyl)-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine)