A solid unit dosage form comprising citalopram, which is prepared by direct compression of a mixture of citalopram base or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients, or by filling of said mixture in a hard gelatine capsule. Large crystals of a pharmaceutical acceptable salt of citalopram and method for the manufacture of said large crystals.

Claims

18 · 1 independent · depth 3

18 granted claims

›1.independentA tablet prepared by direct compression of crystals of a pharmaceutically acceptable salt of citalopram and pharmaceutically acceptable excipients, wh…+17

›2.↳ 1The tablet according to claim 1 which does not contain a binder.d2

›3.↳ 1The tablet according to claim 1 which contains 2-60% w/w active ingredient calculated as citalopram base.d2

›4.↳ 1The tablet according to claim 1 which contains a filler selected from lactose, sugars, calcium phosphates, starch, modified starches, microcrystalline…d2+3

›6.↳ 1The tablet according to claim 1 which contains a lubricant selected from metallic stearates, stearic acid, wax, hydrogenated vegetable oil, talc and c…d2+2

›8.↳ 1The tablet according to claim 1 which is substantially free of lactose.d2

›9.↳ 1The tablet according to claim 1 wherein the pharmaceutically acceptable salt is citalopram hydrobromide or citalopram hydrochloride.d2+1

›11.↳ 1The tablet of claim 1, which contains 10-40% w/w active ingredient calculated as citalopram base.d2

›12.↳ 1The tablet of claim 1, which contains 15-25% w/w active ingredient calculated as citalopram base.d2

›16.↳ 1The tablet of claim 1, wherein the crystals have a median particle size of 40-200 μm.d2

›17.↳ 1The tablet of claim 1, wherein the crystals have a median particle size of 45-150 μm.d2

›18.↳ 1The tablet of claim 1, wherein the crystals have a median particle size of 50-100 μm.d2

Classifications

2 codes

USPC · US Patent Classification

514/469549/467

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File wrapper

Pendency

4.2 y

1,519 days filing → grant

Office actions

non-final + final

Responses

5 RCE

Examiner

Charanjit S. Aulakh

art unit 1625 · TC 1600

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Citations: 45 back · 0 forward

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Priority chain

1 priority documents

›Priority documents — 1

Type	Document	Date
related publication	US 20030109577 A1	12 Jun 2003

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