Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Claims

28 · 3 independent · depth 5

28 granted claims

›1.independentAn implant device comprising a flexible body formed from a single wall, which defines an interior with a volume, the flexible body constructed to have…+23

›2.↳ 1An implant device as defined in claim 1 wherein the implant has at least one opening to the interior.d2+15

›3.↳ 2An implant as defined in claim 2 wherein an angiogenic substance is associated with the interior of the device.d3+2

›6.↳ 2An implant as defined in claim 2 wherein at least one of the openings comprises a check valve configured to permit inflow of blood.d3

›7.↳ 2An implant defined in claim 2 wherein the implant is configured to permit blood inflow into the interior while in the first configuration.d3+2

›10.↳ 2An implant as defined in claim 2 wherein the implant further comprises a flexible capsule.d3+2

›13.↳ 2An implant as defined in claim 2 wherein the implant further comprises a tube.d3+4

›18.↳ 1The implant defined in claim 1 wherein an angiogenic substance to promote angiogenesis is associated with the implant.d2+4

›23.↳ 1An implant as defined in claim 1 wherein the implant is configured to irritate the surrounding tissue as the implant moves between its first and secon…d2+1

›25.independentAn implant for implantation in the myocardium of a patient comprising; a flexible body formed from a single wall of flexible material defining an inte…

›26.independentA device for promoting angiogenesis in the myocardium comprising: a carrier having a single wall defining a pump with a chamber implantable in the myo…+2

Classifications

1 codes

USPC · US Patent Classification

623/1.1

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Gene Mancene

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