Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.

Claims

10 · 1 independent · depth 3

10 granted claims

›1.independentA recombinant chimeric antibody molecule comprising TNF-R sequences substituted for the variable domains of either or both of the immunoglobulin molec…+9

›2.↳ 1The recombinant chimeric antibody molecule of claim 1, wherein said TNF-R sequences are substituted for the variable domains of the immunoglobulin mol…d2+1

›4.↳ 1multiple · 1, 2, 3The recombinant chimeric antibody molecule of claim 1, 2 or 3, wherein said extracellular ligand binding domain comprises amino acid 1-163 of FIG. 2A.d2+1

›5.↳ 1multiple · 1, 2, 3The recombinant chimeric antibody molecule of claim 1, 2 or 3, wherein said extracellular ligand binding domain comprises amino acids 1-185 of FIG. 2A…d2+1

›6.↳ 1multiple · 1, 2, 3The recombinant chimeric antibody molecule of claim 1, 2 or 3, wherein said extracellular ligand binding domain comprises amino acids 1-235 of FIG. 2A…d2+1

›7.↳ 1multiple · 1, 2, 3A pharmaceutical composition comprising the recombinant chimeric antibody molecule of claim 1, 2 or 3, and a pharmaceutically acceptable diluent or ca…d2

Classifications

6 codes

USPC · US Patent Classification

424/134.1530/333530/387.3435/69.7530/387.9530/350

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3.5 y

1,292 days filing → grant

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Examiner

Christine Saoud

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