The present invention is directed to compositions, and methods for the delivery of drugs. Devices for the transdermal delivery of drugs are also provided. Specifically, the present invention relates to hydrogel compositions comprising water and a base mixture, in which the base mixture comprises: (i) a gelling agent consisting of methycellulose or at least one natural gum, or a mixture thereof; (ii) at least one natural gum: (iii) glucose; (iv) propylparaben; (v) methyl paraben; and (vi) sodium chloride. The compositions may further comprise pectin, glycolic, alcoholic or oil-based additives, a coloring, fragrance, or other pharmaceutically acceptable additive. The compositions may further comprise substituted ureas of the formula R--NH--CO--NH.sub.2 such as butylurea. The compositions may further comprise drugs such as hormones selected from progesterone, progestin, estrogen and testosterone. Methods for the treatment of disorders responsive to hormone therapy are also provided.

Claims

17 · 4 independent · depth 4

17 granted claims

›1.independentA composition consisting essentially of: (a) 3-12% of a base mixture consisting essentially of: 50-80% (by weight) methyl cellulose, 15-25% of a natur…+13

›5.↳ 1multiple · 1, 2A method of treating or preventing a condition responsive to hormone replacement therapy comprising placing a composition of claim 1 or 2, said compos…d2+1

›7.↳ 1multiple · 1, 2A method of providing contraception to a male or female subject comprising placing a composition of claim 1 or 2, said composition comprising a therap…d2+5

›13.↳ 1multiple · 1, 2A method of delivering a therapeutically effective amount of a hormone or mixture of hormones to the bloodstream of a subject comprising contacting th…d2

›14.↳ 1multiple · 1, 2A method for treating vaginal yeast infection comprising placing a composition of claim 1 or 2 inside the vagina of a female subject suffering from ye…d2

›15.↳ 1multiple · 1, 2A method for providing contraception to a female subject comprising placing a composition of claim 1 or 2 inside the vagina of a female subject in nee…d2

›16.↳ 1multiple · 1, 2A method for treating vaginal dryness comprising placing a composition of claim 1 or 2 inside the vagina of a female subject suffering from vaginal dr…d2

›17.↳ 1multiple · 1, 2A method for vaginal delivery of a drug comprising placing a composition of claim 1 or 2 inside the vagina of a female subject.d2

›2.independentA composition consisting essentially of: (a) about 9% by weight of a base mixture consisting essentially of: about 63% (by weight) methyl cellulose, a…

›3.independentA composition consisting essentially of: (a) about 9% by weight of a base mixture consisting essentially of: about 63% (by weight) methyl cellulose, a…

›4.independentA composition consisting essentially of: (a) a base mixture consisting essentially of methyl cellulose, guar gum, glucose, propylparaben, methyl parab…

Classifications

5 codes

USPC · US Patent Classification

424/449424/430424/455424/443424/484

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S. Mark Clardy

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