A compound of formula (I) R.sup.1 R.sup.2 NCOCH.sub.2 N(R.sup.3)COR.sup.4 (I) and physiologically acceptable salts thereof wherein R.sup.1 is C.sub.3-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 alkenyl, phenyl, --(CH.sub.2).sub.p CN or --(CH.sub.2).sub.p COO(C.sub.1-4 alkyl) and R.sup.2 is C.sub.3-6 cycloalkyl, C.sub.3-6 alkenyl, benzyl, phenyl, or phenyl mono- or disubstituted independently with C.sub.1-3 alkyl, cyano, hydroxy, dimethylamino, --O(C.sub.1-4 alkyl), --O(CII.sub.2 C.sub.6 II.sub.5), --NH(C.sub.1-4 alkyl), --COOC(C.sub.1-4 alkyl), --N(C.sub.1-4 alkyl).sub.2 pyrrolidino, morpholino, halogen, or C.sub.1-3 alkyl substituted by one or more fluorine atoms, or R.sup.1 is C.sub.1-2 alkyl and R.sup.2 is phenyl substituted at the 2- or 4-position with chloro, methyl, methoxy, or methoxycarbonyl; R.sup.4 is a group of formula (III) ##STR13## where n is 0, 1, 2 or 3; p is the integer 0 or 1; q is the integer 0 or 1; r is the integer 0 or 1, provided that when q is 0 then r is 0; R.sup.9 is hydrogen or C.sub.1-6 alkyl; R.sup.5 is C.sub.1-6 alkyl,C.sub.3-6 cycloalkyl, phenyl, phenyl mono-, di or trisubstituted independently with C.sub.1-4 alkyl, hydroxy, C.sub.1-6 alkoxy, halogen, amino, mono- or di(C.sub.1-6 alkyl)amino, nitro, carboxy, --COO(C.sub.1-4 alkyl), carboxyC.sub.1-6 alkoxy, carboxyC.sub.1-4 alkyl, carboxymethylthio, heteroaryl, mono- or di(C.sub.1-6 alkyl)aminoalkyl, or trifluoromethyl, trifluoromethoxy, C.sub.1-4 alkylthio, --SO.sub.v (C.sub.1-4 alkyl), --SO.sub.V NH(C.sub.1-4 alkyl), --SO.sub.v CF.sub.3 or --SO.sub.v C.sub.6 H.sub.5, --(CH.sub.2).sub.v,NO.sub.2, --(CH.sub.2).sub.v CN, --(CH.sub.2).sub.v COOH, --(CH.sub.2).sub.v COO(C.sub.1-4 alkyl), --(CH.sub.2).sub.v SCH.sub.3, --(CH.sub.2).sub.v SOCH.sub.3, --(CH.sub.2).sub.v SO.sub.3 H, CH(C.sub.1-3 alkyl)SO.sub.3 H, CH(C.sub.1-3 alkyl)CO.sub.2 H, (CH.sub.2).sub.v SO.sub.2 CH.sub.3, --(CH.sub.2).sub.v CONH.sub.2, --SCH.sub.2 COOH, --CONH(SO.sub.2 CH.sub.3), --CONH(SO.sub.2 CF.sub.3)--(CH.sub.2).sub.v N(C.sub.1-4 alkyl.sub.2, --(CH.sub.2).sub.v NH(SO.sub.2 CF.sub.3) --CH.sub.2).sub.v N(SO.sub.2 CF.sub.3)C.sub.1-4 alkyl), --(CH.sub.2).sub.v SO.sub.2 N(HCOC.sub.1-4 alkyl)-(CH.sub.2).sub.v SO.sub.2 N(C.sub.1-4 alkyl),CO(C.sub.1-4 alkyl), --(CH.sub.2).sub.v CONHSO.sub.2 (C.sub.1-4 alkyl), --(CH.sub.2).sub.v CON(C.sub.1-4 alkyl)SO.sub.2 (C.sub.1-4 alkyl), --(CH.sub.2).sub.v NHR.sup.10 or (CH.sub.2).sub.v OR.sup.11 substituents; heteroaryl (provided when R.sup.5 is oxadiazole then R.sup.9 is not hydrogen), heteroaryl substituted with halogen, C.sub.1-6 alkyl, hydroxy, nitro, cyano, carboxy, C.sub.1-6 alkoxy, benzoxy, --COO(C.sub.1-4 alkyl), amino, mono- or di(C.sub.1-6 alkyl)amino, phenyl or benzyl substituents; naphthyl; bicycloheteroaryl or bicycloheteroaryl N-substituted independently with hydroxy, carboxyalkyl, phenyl, heteroaryl, C.sub.1-4 alkoxy or cyano substituents, further provided when n is 1, p is 0, q is 0 and r is 0 then heteroaryl, substituted heteroaryl, bicycloheteroaryl and substituted bicycloheteroaryl are bound at the 3 position, still further provided that when n is 0, p is 1, q is 1 and r is 0 then heteraryl, substituted heteroaryl, bicycloheteroaryl and substituted bicycloheteroaryl are bound at the 2 position; R.sup.10 is hydrogen acetyl, C.sub.1-4 alkyl, SO.sub.3 H, --SO.sub.2 CH.sub.3, --SO.sub.2 CF.sub.3, --SO.sub.2 C.sub.6 H.sub.5, C.sub.1-4 alkoxycarbonyl R.sup.11 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 COOH, --CH.sub.2 CONH.sub.2, --CH.sub.2 CONH(C.sub.1-4 alkyl), --CH.sub.2 CON(C.sub.1-4 alkyl).sub.2 or ##STR14## v 0, 1 or 2; c is zero or 1 R.sup.3 and R.sup.6 together form a linking chain ##STR15## wherein the group Z is linked to the rest of the molecule at the carbon atom substituted by the group R.sup.9 and wherein Z is CH.sub.2, C(CH.sub.3).sub.2, --C(CH.sub.3) or CO, Y is a group selected from S, SO, SO.sub.2, CO or CH.sub.2, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 each represent hydrogen, or R.sup.13 and R.sup.14 together form a double bond and R.sup.12 and R.sup.15 are both hydrogen.
