A compound of the formula ##STR133## wherein, X is --O--, --S--, --NH--, or --N(R.sub.2)--; R.sub.2 is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, alkoxycarbonyl, and phenysulfonyl groups; aryl is as defined hereinafter; p is 1 or 2; Y is hydrogen, lower alkyl, hydroxy, chlorine, fluorine, bromine, iodine, lower alkoxy, trifluoromethyl, nitro, or amino; R.sub.1 is --CR.sub.24 R.sub.27 --(CR.sub.23 R.sub.24).sub.n --CR.sub.24 R.sub.27 -- where n is 0, 1, 2, or 3; or --CHR.sub.24 --CH.dbd.CH--CHR.sub.24 --, --CHR.sub.24 --C.ident.C--CHR.sub.24 --, --CHR.sub.24 --CH.dbd.CH--CR.sub.23 R.sub.24 --CHR.sub.24 --, --CHR.sub.24 --CR.sub.23 R.sub.24 --CH.dbd.CH--CHR.sub.24 --, --CHR.sub.24 --C.ident.C--CR.sub.23 R.sub.24 --CHR.sub.24 --, or --CHR.sub.24 --CR.sub.23 R.sub.24 --C.ident.C--CHR.sub.24 --, the --CH.dbd.CH-- bond being cis or trans; R.sub.23 is hydrogen, (C.sub.1 -C.sub.18)linear alkyl, phenyl, hydroxy, (C.sub.1 -C.sub.18) alkoxy, aryloxy, aryl (C.sub.1 -C.sub.18) alkyloxy, (C.sub.1 -C.sub.18) alkanoyloxy, hydroxy (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.18) alkoxy (C.sub.1 -C.sub.6) alkyl, phenyl (C.sub.1 -C.sub.6) alkoxy, aryl (C.sub.1 -C.sub.18) alkyloxy (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.18) alkanoyloxy (C.sub.1 -C.sub.6) alkyl, or ##STR134## where Z.sub.1 is lower alkyl, --OH, lower alkoxy, --CF.sub.3, --NO.sub.2, --NH.sub.2, or halogen, and p is as previously defined; and R.sub.24 is hydrogen, (C.sub.1 -C.sub.18)linear alkyl, phenyl, hydroxy (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.18) alkoxy (C.sub.1 -C.sub.6) alkyl, phenyl (C.sub.1 -C.sub.6) alkyloxy, aryl (C.sub.1 -C.sub.18) alkyloxy (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.18) alkanoyloxy (C.sub.1 -C.sub.6) alkyl, or ##STR135## where Z.sub.1 is as previously defined, and p is as previously defined; R.sub.27 is hydrogen or R.sub.24 and R.sub.27 taken together with the carbon to which they are attached form C.dbd.O or C.dbd.S; R.sub.12 is selected from the group consisting of: hydrogen, alkyl, --C (.dbd.O)--(C.sub.1 -C.sub.18) straight chain or branched ) alkyl, --C (.dbd.O)--NR.sub.13 R.sub.14, --C (.dbd.O)--NR.sub.15 R.sub.16, and --S (.dbd.O).sub.2 --R.sub.17 ; where R.sub.13 is selected from the group consisting of hydrogen and (C.sub.1 -C.sub.18) alkyl groups; where R.sub.14 is selected from the group consisting of hydrogen and (C.sub.1 -C.sub.18) alkyl groups; where NR.sub.15 R.sub.16 taken together form a ring structure selected from the group consisting of piperidinyl, morpholinyl, and piperazinyl; where R.sub.17 is selected from the group consisting of (C.sub.1 -C.sub.18) alkyl and aryl groups; in which aryl is phenyl or ##STR136## where R.sub.5 is hydrogen, lower alkoxy, hydroxy, chlorine, fluorine, bromine, iodine, lower monoalkylamino, lower dialkylamino, nitro, cyano, trifluoromethyl, or trifluoromethoxy; all geometric, optical, and stereoisomers thereof; or a pharmaceutically acceptable acid addition salt thereof.
›2.↳ 1The compound of claim 1, wherein X is --N(R.sub.2)--.d2+1
The compound of claim 1, wherein X is --N(R.sub.2)--.
›3.↳ 2The compound of claim 2, wherein R.sub.2 is (C.sub.1 -C.sub.18) alkanoyl or (C.sub.1 -C.sub.18)alkoxycarbonyl.d3
The compound of claim 2, wherein R.sub.2 is (C.sub.1 -C.sub.18) alkanoyl or (C.sub.1 -C.sub.18)alkoxycarbonyl.
›4.↳ 1An antipsychotic composition, which comprises the compound of claim 1 in an amount sufficient to produce an antipsychotic effect and a pharmaceuticall…d2
An antipsychotic composition, which comprises the compound of claim 1 in an amount sufficient to produce an antipsychotic effect and a pharmaceutically acceptable carrier.
›5.↳ 1A method of treating psychoses, which comprises administering to a mammal a psychoses-treating amount of the compound of claim 1.d2
A method of treating psychoses, which comprises administering to a mammal a psychoses-treating amount of the compound of claim 1.
›6.↳ 1An analgesic composition, which comprises the compound of claim 1 in an amount sufficient to produce a pain-relieving effect and a pharmaceutically ac…d2
An analgesic composition, which comprises the compound of claim 1 in an amount sufficient to produce a pain-relieving effect and a pharmaceutically acceptable carrier.
›7.↳ 1A method of alleviating pain, which comprises administering to a mammal a pain-relieving effective amount of the compound of claim 1.d2
A method of alleviating pain, which comprises administering to a mammal a pain-relieving effective amount of the compound of claim 1.
›8.↳ 1A depot pharmaceutical composition, which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of cl…d2+8
A depot pharmaceutical composition, which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of claim 1, wherein the compound contains a hydroxy group, an amino group, or a nitrogen at the 1-position of an indazole ring, which has been acylated.
›9.↳ 8The depot pharmaceutical composition of claim 8, wherein the hydroxy group or amino group is acylated with a (C.sub.4 -C.sub.18)alkanoyl group or a (C…d3+3
The depot pharmaceutical composition of claim 8, wherein the hydroxy group or amino group is acylated with a (C.sub.4 -C.sub.18)alkanoyl group or a (C.sub.4 -C.sub.18)alkoxycarbonyl group.
›12.↳ 9The composition of claim 9, which contains a pharmaceutically acceptable oil.d4
The composition of claim 9, which contains a pharmaceutically acceptable oil.
›13.↳ 9The composition of claim 9, wherein the oil is selected from the group consisting of coconut oil, peanut oil, sesame oil, cotton seed oil, corn oil, s…d4
The composition of claim 9, wherein the oil is selected from the group consisting of coconut oil, peanut oil, sesame oil, cotton seed oil, corn oil, soybean oil, olive oil, and synthetic esters of fatty acids and polyfunctional alcohols.
›15.↳ 9A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 9 sufficient …d4
A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 9 sufficient to produce a long acting antipsychotic effect.
›10.↳ 8The composition of claim 8, which contains a pharmaceutically acceptable oil.d3+1
The composition of claim 8, which contains a pharmaceutically acceptable oil.
›11.↳ 10The composition of claim 10, wherein the oil is selected from the group consisting of coconut oil, peanut oil, sesame oil, cotton seed oil, corn oil, …d4
The composition of claim 10, wherein the oil is selected from the group consisting of coconut oil, peanut oil, sesame oil, cotton seed oil, corn oil, soybean oil, olive oil, and synthetic esters of fatty acids and polyfunctional alcohols.
›14.↳ 8A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 8 sufficient …d3+1
A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 8 sufficient to produce a long acting antipsychotic effect.
›16.↳ 14A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 14 sufficient…d4
A method for providing a long acting antipsychotic effect, which comprises injecting into a mammal an amount of the composition of claim 14 sufficient to produce a long acting antipsychotic effect.
