A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipid moiety covalently attached thereto is provided. In particularly preferred embodiments, the biocompatible material has the following structure: ##STR1## wherein: R.sup.1 is a (C.sub.1 -C.sub.30)alkyl group; R.sup.2 is a (C.sub.1 -C.sub.30)alkylene group; m is 1-4; n is 1-4; and L is a divalent linking group covalently bonded to the substrate and to the phospholipid moiety.

Claims

19 · 3 independent · depth 6

19 granted claims

›1.independentA biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provid…+10

›2.↳ 1The biocompatible material of claim 1 wherein the phospholipid moiety contains a choline moiety and a phosphate polar group.d2+6

›8.↳ 1The biocompatible material of claim 1 wherein the substrate is an organic polymer.d2+1

›10.↳ 1A medical device comprising the biocompatible material of claim 1.d2

›12.independentA method for enhancing the biocompatibility of a substrate comprising: (a) covalently attaching a phospholipid compound to the substrate in an amount …+6

›13.↳ 12The method of claim 12 wherein the phospholipid compound has the following structure: ##STR9## wherein: (a) R.sup.3 is a (C.sub.1 -C.sub.30)alkyl grou…d2+2

›16.↳ 12The method of claim 12 wherein the substrate is an organic polymer.d2+2

›19.independentA biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provid…

Classifications

3 codes

USPC · US Patent Classification

424/423523/112.113,514/822

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1.5 y

550 days filing → grant

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Examiner

Carlos Azpuru

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