The present invention is related to new basically substituted ureas having the general Formula I ##STR1## and the pharmaceutically acceptable acid addition salts thereof which produce an improved antiviral activity against DNS- and RNS-viruses. The invention is further related to the treatment of humans or animals suffering from diseases caused by viruses by administering compositions containing such ureas or salts thereof as active agent.

Description

14 parts

›The present invention is related to new basically…

The present invention is related to new basically substituted urea compounds and salts thereof which have a high antiviral activity against DNS- and RNS-viruses. The present invention is further related to processes for producing the same and to compositions comprising the same as active agent such compositions being useful in the treatment of diseases caused by viruses both in humans and animals.

The development of compounds having antiviral activity up to now yielded only into very few products which are actually used in the treatment of diseases caused by viruses. Furthermore, the known products used in antiviral chemotherapy or still in development to a great extent only show activity against a very limited spectrum of viruses covering only certain subtypes of viruses. On the other hand, the nucleoside analoga acting as antimetabolites show a considerable cytotoxic activity and severe influence upon the metabolism of healthy cells which activity may yield into severe undesirable side effects such as teratogenicity, anemia, ataxia, stomatitis, loss of finger nails, thrombocytopenia and the like. Other known compounds only act as unspecific immunstimulators.

The basically substituted ureas accordng to the present invention with improved antiviral activity correspond to the general Formula I ##STR2## wherein

X is oxygen or the group R 4 --N<,

p is 2 or 3,

R 1 is an alkyl group having from 6 to 18, preferably from 6 to 14 carbon atoms, most preferred in a straight chain,

R 2 and R 3 , which may be the same or different, represent methyl or ethyl and

R 4 is methylsulfonyl, diethyl carbamoyl or the group ##STR3## wherein q is 1 or 2, preferably 2, and R 8 is methyl, methoxy, chlorine, bromine, and preferably methyl, methoxy or chlorine. The invention embraces also the pharmaceutically acceptable salts thereof.

In view of their particularly high activity most preferred are

(a) N,N'-dimethyl-N-tetradecyl-N'-[2-(1-diethyl carbamoyl-4-piperazinyl)-ethyl]-urea and the pharmaceutically acceptable salts thereof, in particular its hydrochloride (Formula I: X=>N--R 4 , p=2, R 1 =n--C 14 H 29 , R 2 and R 3 =CH 3 , R 4 =diethyl carbamoyl);

(b) N,N'-dimethyl-N-tetradecyl-N'-{2-[1-(2-p-toluylethyl)-4-piperazinyl]-ethyl}-urea and the pharmaceutically acceptable salts thereof, in particular its dihydrochloride (Formula I: X=>N--R 4 , p=2, R 1 =n--C 14 H 29 , R 2 and R 3 =CH 3 , R 4 = ##STR4##

(c) N,N'-dimethyl-N-hexyl-N'-(2-morpholino-ethyl)-urea and the pharmaceutically acceptable salts thereof, in particular its hydrochloride (Formula I: X=O, p=2, R 1 =n--C 6 H 13 , R 2 and R 3 =CH 3 ).

The compounds according to the present invention and the pharmaceutically acceptable salts thereof are characterized by a broad spectrum of antiviral activity covering both DNS- and RNS-viruses. The compounds have a low toxicity and a direct activity to the replication cyclus of the viruses.

The compounds according to the present invention and the salts thereof are useful in human medicine, in particular for the topical treatment of diseases caused by viruses, in particular diseases of the skin, of the cornea of the eyes and of mucous membrances. Examples for such diseases are herpes labialis, herpes genitalis, herpes corneae (herpes ceratitis), herpes zoster, exzema vaccinatum, vaccina progressiva gangrenosa, stomatitis aphthosa or condylomata acuminata. Furthermore, the compounds are useful for the systematical prophylaxes or therepeutic treatment of acute viral infections of the upper respiratory tract such is influenca, bronchitis, rhinitis, rhinopharyngitis, as well as of acute viral infections of the central nervous system such as herpes encephalitis, and of virus hepatitis. Furthermore, the products are very useful in the treatment of many diseases of animals caused by viruses.

The compounds are applied for topical uses in a dose range from 0.005 to 0.3, preferably 0.01 to 0.1 percent by weight and for parenteral uses at a daily dose ranging from 5 to 250, preferably 10 to 200 mg per kg body weight depending upon the weight of the species to be treated, and for systemic oral uses in humans at a daily dose of about 300 mg.

The ureas according to the present invention and the pharmaceutically acceptable salts thereof may be produced by any of the processes given hereinafter and known as such:

(A) a compound of the general Formula II is subjected to reaction with a compound of the general Formula III ##STR5## wherein X, p, R 1 , R 2 and R 3 have the same meaning as given for Formula I and Q is a halogen atom or an alkyl sulfonyloxy group, in particular a lower alkyl sulfonyloxy group wherein the alkyl group has 1 to 6 carbon atoms;

(B) a compound of the general Formula IV is subjected to reaction with a compound of general Formula V ##STR6## wherein X, p, R 1 , R 2 and R 3 have the same meaning as given for Formula I and Q has the same meaning as given for Formula III;

(C) a compound of the general Formula VI is subjected to reaction with a compound of the general Formula VII ##STR7## wherein X, p, R 1 , R 2 and R 3 have the same meaning as given for Formula I and Z is a groupment such as a halogen atom, an alkoxy group, a phenoxy group or an imidazolyl group, or forms a double bond as ##STR8##

The compounds according to Formula I may be furthermore produced by subjecting a compound of Formula I, wherein R 2 and/or R 3 represent hydrogen, to reaction with a suitable alkylating agent such is an alkyl halogenide or an alkyl ester of a sulfuric acid or of a sulfonic acid which reaction is known as such.

All of the above methods for producing the compounds according to the present invention are carried out in suitable organic solvents. Preferably equimolar amounts of the reaction components are used. If Q and/or Z is a halogen atom, an acid binding agent may be used in an appropriate amount in order to neutralize the hydrohalogen acid H--Q or H--Z formed.

In the alkylating reaction B suitable solvents are benzene, toluene, dioxane and tetrahydrofurane and, above all, the dipolar aprotic solvents such as dimethylsulfoxide, dimethylformamide, acetonitril and the like. Suitable condensation agents (acid binding agents) are in particular alkali metal hydrides, amides, alcoholates or hydroxides. The reaction is carried out at temperatures between 0° C. and 110° C. depending upon the solvent and condensation agent actually used. The reaction A is carried out in a solvent as above enumerated or in a lower alcohol. Useful acid binding agents for this reaction are for instance potassium carbonate and in particular triethylamine. If no acid binding agent is used the corresponding salts of the claimed compounds are obtained directly. The addition of amines VI to isocyanates VII and the carbamoylation of amines VI (process C) is carried out in inert solvents, preferably in aromatic hydrocarbons such as benzene and toluene or in ethers such as dioxane and tetrahydrofurane. The reaction may be carried out in the presence of an acid binding agent such as triethylamine or pyridine. The reaction C is carried out at temperatures ranging from 0° C. and 110° C.

›The starting products used in all of the…

The starting products used in all of the processes above described are produced by standard methods. The carbamoyl compounds of general Formula VII, if not available as trade product, may be produced from the corresponding amines as described in Houben-Weyl Vol. 8, p. 119 to 128, or Vol. 8, p. 115 to 117. The ureas of the general Formula III and V are produced for instance as described in Houben-Weyl Vol. 8, p. 149 to 162.

The compounds of the general Formula I may be converted into acid addition salts. Useful acids for producing pharmaceutically acceptable acid addition salts are for instance hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methane sulfonic acid, acetic acid, lactic acid, fumaric acid, maleic acid, tataric acid, citric acid, salicic acid or embonic acid and the like.

The following examples serve to further illustrate the preparation of the compounds according to the present invention without however limiting the same thereto.

›Examples5

›EXAMPLE 1

N,N'-Dimethyl-N-(n-tetradecyl)-N'-[2-(1-diethylcarbamoyl-4-piperazinyl)-ethyl]-urea ##STR9##

14.5 g (0.05 mole) of methyl-(n-tetradecyl)-carbamic acid chloride are dissolved in 20 cc. of toluene. This solution is added at room temperature with stirring dropwise to a solution of 12.1 g (0.05 mole) of 1-diethylcarbamoyl-4-(2-methylamino ethyl)-piperazine and 5.1 g (0.05 mole) of triethylamine in 40 cc. of toluene. After completion of the addition, the resulting mixture is stirred at about 100° for another hour. The precipitated triethylamine hydrochloride is filtered off from the cooled reaction mixture and the filtrate is evaporated. The residue is taken up in 150 cc. of ether, the ethereal solution is washed three times with 150 cc. of water each time and is dried over anhydrous Na 2 SO 4 . Upon evaporation of the ether, 23.5 g (94.8% of the theoretical) of the oily crude urea are obtained.

For preparing the hydrochloride, the crude urea is dissolved in anhydrous ether and the equivalent amount of an ethereal solution of HCl is added dropwise with stirring and cooling.

M.p.: 167° to 170° C. (recrystallized from acetic acid ethyl ester admixed with a small amount of methanol).

›EXAMPLE 2

N,N,N'-Trimethyl-N'-[2-(1-diethylcarbamoyl-4-piperazinyl)-ethyl]-urea ##STR10##

5.4 g (0.05 mole) of dimethyl carbamic acid chloride dissolved in 20 cc. of toluene are added dropwise with stirring at room temperature to a solution of 12.1 g (0.05 mole) of 1-diethylcarbamoyl-4-(2-methylamino ethyl)-piperazine and 5.1 g (0.05 mole) of triethylamine in 40 cc. of toluene. Thereafter, the reaction mixture is stirred for another hour at about 100° C. The reaction mixture is cooled and the precipitated triethylamine hydrochloride is filtered off with suction and the filtrate is evaporated. The residue is dissolved in 150 cc. of ether, the ethereal solution is washed twice with 150 cc. of 5 n NaOH each time and the resulting solution is dried over anhydrous Na 2 SO 4 . Upon evaporation of the ether, 15.3 g (97.6% of the theoretical) of the oily crude urea are obtained.

Hydrochloride: M.p.: 193° to 196° C. (recrystallized from aceton admixed with a small amount of methanol).

›EXAMPLE 3

N,N'-Dimethyl-N-(n-decyl)-N'-[3-(1-diethylcarbamoyl-4-piperazinyl)-propyl]-urea ##STR11##

4.7 g (0.02 mole) of methyl-n-decylcarbamic acid chloride are added dropwise to 5.1 g (0.02 mole) of N-diethylcarbamoyl-N'-γ-methylamino-propyl-piperazine and 2 g (0.02 mole) of triethylamine in 50 cc. of dioxane. After completion of the addition, the resulting reaction mixture is stirred for another hour at room temperature, the precipitated triethylamine hydrochloride is filtered off with suction and the filtrate is evaporated in a vacuum.

For producing the hydrochloride, the obtained crude base is dissolved in anhydrous ether and an ethereal solution of HCl is added thereto. The hydrochloride is filtered off with suction and is further purified by recrystallization from acetic acid ethyl ester.

Yield: 4.3 g (43.9% of the theoretical).

M.p.: 112° to 114° C.

›EXAMPLE 4

N,N'-Dimethyl-N-(n-tetradecyl)-N'-[2-(1-methanesulfonyl-4-piperazinyl)-ethyl]-urea ##STR12##

14.5 g (0.05 mole) of methyl-(n-tetradecyl)-carbamic acid chloride dissolved in 20 cc. of dioxane are added dropwise with stirring at room temperature to a solution of 11.1 g (0.05 mole) of 1-methanesulfonyl-4-(2-methylamino-ethyl)-piperazine and 5.1 g (0.05 mole) of triethylamine in 40 cc. of dioxane. The reaction mixture thereafter is stirred for one hour at about 100° C. After cooling, the precipitated triethylamine hydrochloride is filtered off with suction and the filtrate is evaporated. The residue is dissolved in 150 cc. of methylene chloride, the resulting solution is washed three times with 150 cc. of water each time and finally is dried over anhydrous Na 2 SO 4 . After removal the methylene chloride, the resulting urea base is recrystallized from acetic acid ethyl ester.

Yield: 18.5 g (77.9% of theoretical).

M.p.: 73° to 75° C.

The hydrochloride is obtained by dissolving the urea base with heating in acetone and adding dropwise with stirring at room temperature the equivalent amount of an ethereal solution of HCl.

M.p.: 153° to 157° C. (from acetic acid ethyl ester and little methanol).

›EXAMPLE 5

N,N-Diethyl-N'-methyl-N'-3-morpholinopropyl-urea hydrochloride ##STR13##

13 g (0.1 mole) of N,N-diethyl-N'methyl urea are dissolved in 100 cc. of anhydrous dioxane. 3.9 g (0.1 mole) of NaNH 2 are added thereto and the reaction mixture is heated one hour at reflux. After cooling, 16.4 g (0.1 mole) of N-(3-chloropropyl)morpholine dissolved in 50 cc. of anhydrous dioxane are added thereto dropwise and the reaction mixture is refluxed for 6 hours. After cooling, the precipitated NaCl is filtered off with suction, the filtrate is evaporated and the remaining residue is subjected to fractionated distillation.

Yield: 12.5 g (48.6% of the theoretical)

B.p. 0.5 mm: 145° to 150° C.

For further purification, the crude base is dissolved in 50 cc. of methanol and is passed through a column of silicagel. A mixture of chloroform, methanol and benzene in a ratio of 2:1:1 is used as solvent. The thus purified base is dissolved in anhydrous ether and the equivalent amount of an ethereal solution of HCl is added thereto. The precipitated hydrochloride is filtered off and recrystallized from ethyl acetate.

M.p.: 130° to 132° C.

The compounds given hereinafter in Table 1 have been prepared by the processes described in the above examples using the appropriate starting materials.

__________________________________________________________________________

##STR14##

›Example

B (CH.sub.2).sub.p

R.sub.1

R.sub.2

R.sub.3

M.p. °C.

__________________________________________________________________________

6 CH.sub.2 CH.sub.2

C.sub.6 H.sub.13

CH.sub.3

173-176

7 CH.sub.2 CH.sub.2

C.sub.8 H.sub.17

CH.sub.3

175-178

##STR15## CH.sub.2 CH.sub.2

C.sub.10 H.sub.21

CH.sub.3

170-173

9 CH.sub.2 CH.sub.2

C.sub.12 H.sub.25

CH.sub.3

171-173

10 CH.sub.2 CH.sub.

C.sub.13 H.sub.27

CH.sub.3

167-169

11 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

161-164

12 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

118-120

13 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

C.sub.2 H.sub.5

99-102

14 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

C.sub.2 H.sub.5

78-84

15 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

C.sub.2 H.sub.5

CH.sub.3

128-131

16 CH.sub.2 CH.sub.2

C.sub.15 H.sub.31

CH.sub.3

167-169

17 CH.sub.2 CH.sub.2

C.sub.16 H.sub.33

CH.sub.3

165-168

18 CH.sub.2 CH.sub.2

C.sub.18 H.sub.37

CH.sub.3

163-166

19 CH.sub.2 CH.sub.2

C.sub.6 H.sub.13

CH.sub.3

117-120

20 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.8 H.sub.17

CH.sub.3

95-97

21 CH.sub.2 CH.sub.2

C.sub.8 H.sub.17

CH.sub.3

123-126

22 CH.sub.2 CH.sub.2

C.sub.10 H.sub.21

CH.sub.3

128-135

23 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.10 H.sub.21

CH.sub.3

100-101

##STR16## CH.sub.2 CH.sub.2

C.sub.12 H.sub.25

CH.sub.3

133-137

25 CH.sub.2 CH.sub.2

C.sub.13 H.sub.27

CH.sub.3

134-138

26 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

102

27 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

139-143

28 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

105-106

29 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

C.sub.2 H.sub.5

116-119

30 CH.sub.2 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

C.sub.2 H.sub.5

109-113

31 CH.sub.2 CH.sub.2

C.sub.15 H.sub.31

CH.sub. 3

CH.sub.3

135-140

32 CH.sub.2 CH.sub.2

C.sub.8 H.sub.17

CH.sub.3

158-161

##STR17## CH.sub.2 CH.sub.2

C.sub.10 H.sub.21

CH.sub.3

159-162

34 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

153-157

35 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

159-162

##STR18## CH.sub.2CH.sub.2

C.sub.9 H.sub.19

CH.sub.3

179-180.sup.(1)

37 CH.sub.2CH.sub.2

C.sub.12 H.sub.25

CH.sub.3

180-181.sup.(1)

38 CH.sub.2CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

169-171.sup.(1)

##STR19## CH.sub.2 CH.sub.2

C.sub.9 H.sub.19

CH.sub.3

172-174.sup.(1)

##STR20## CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

177-179.sup.(1)

41 CH.sub.2 CH.sub.2

C.sub.9 H.sub.19

CH.sub.3

180-182.sup.(1)

##STR21## CH.sub.2 CH.sub.2

C.sub.12 H.sub.25

CH.sub.3

206-208.sup.(1)

43 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

202-204.sup.(1)

##STR22## CH.sub.2 CH.sub.2

C.sub.12 H.sub.

CH.sub.3

199-201.sup.(1)

45 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

204-206.sup.(1)

##STR23## CH.sub.2 CH.sub.2

C.sub.9 H.sub.19

CH.sub.3

197-198.sup.(1)

47 CH.sub.2 CH.sub.2

C.sub.12 H.sub.25

CH.sub.3

195-197.sup.(1)

48 CH.sub.2 CH.sub.2

C.sub.14 H.sub.29

CH.sub.3

212-213.sup.(1)

__________________________________________________________________________

.sup.(1) Fp. als Dihydrochlorid

Pharmaceutical preparation have been prepared from the compound of Example 19 as described in the following examples:

›Examples6

›EXAMPLE 49

______________________________________

Coated tablets, 50 mg. of urea base

______________________________________

1 tablet contains:

N,N'-dimethyl-N-hexyl-N'-(2-morphilinoethyl)-

urea hydrochloride 56.4 mg.

Calciumhydrogenphosphate DAB 7

24.6 mg.

Talcum Eu.A.B. III 5.0 mg.

Avicel PH 101 19.0 mg.

Corn starch Eu.A.B. I 20.0 mg.

Aerosil 200 1.5 mg.

Polyplasdone XL 7.5 mg.

Magnesium stearate USP XIX

1.0 mg.

135.0 mg.

______________________________________

N,N'-Dimethyl-N-hexyl-N'-(2-morpholinoethyl)-urea hydrochloride, calcium hydrogenphosphate and talcum are passed through a sieve having a mesh width of 1 mm, are mixed in a vortex granulator and are granulated by spraying with water. The relative humidity of the granulate should be 45%. Thereafter, the granulate together with Avicel, corn starch, Aerosil, Polyplasdone XL and magnesium stearate is passed through a sieve having a mesh width of 0.8 mm, and all components are mixed until a homogenous product is obtained. The resulting mixture is pressed to kernels having a diameter of 7 mm, a curvature radius of 5 mm and weighing each 135 mg.

The resulting kernels are film coated with 4 mg. each of a film consisting of lacquer, softening agent and color pigments in usual manners in a vortex coating machine.

›EXAMPLE 50

______________________________________

Injection solution, containing 0.1% of urea base per ml.

______________________________________

Ampoules of 5 cc. (containing 5 mg.

of active agent)

Ampoules of 10 cc. (containing 10 mg.

of active agent)

1 ml. contains:

N,N'-dimethyl-N-hexyl-N'

(2-morpholinoethyl)-urea

hydrochloride 1.13 mg.

Sodium chloride 4.30 mg.

Sodium dihydrogenphosphate DAB 7

1.97 mg.

Sodium monohydrogenphosphate DAB 7

19.30 mg.

Water for injection filled up to

1.0 ml.

______________________________________

The active agent and the other components are dissolved in part of the water for injection and the solution is filled up to the final volume.

The solution is subjected to sterile filtration through a membrane filter under nitrogen and is filled into the ampoules under aseptic conditions to give

(a) clear glass ampoules containing 5.3 ml. of the solution and

(b) clear glass ampoules containing 10.5 ml. of the solution.

›EXAMPLE 51

______________________________________

Skin gel containing 0.03% of urea base

______________________________________

1 g of gel contains:

N,N'-dimethyl-N-hexyl-N'

(2-morpholinoethyl)-urea

hydrochloride 0.34 mg.

Sodium dihydrogenphosphate DAB 7

10.25 mg.

Sodium monohydrogenphosphate DAB 7

0.36 mg.

Phenethanol DAC 5.00 mg.

Natrosol 250 HHR 18.00 mg.

Purified water Eu.A.B. I, filled up to

1000.00 mg.

______________________________________

The active agent, the phosphates and Phenethanol are dissolved in water whereafter the Natrosol is admixed in a high speed dispersion machine. The mixture is heated to 40° C. with stirring resulting into a clear homogenous gel.

›EXAMPLE 52

______________________________________

Creme o/w containing 0.03% of the urea base

______________________________________

1 g of the creme contains:

N,N'-dimethyl-N-hexyl-N'

(2-morpholinoethyl)-urea

hydrochloride 0.34 mg.

Arlatone 983 (Atlas) 60.00 mg.

Cetostearyl alcohol DAB 7 20.00 mg.

Stearic acid 40.00 mg.

Paraffin. perliqu. DAB 7 100.00 mg.

Oleum neutrale DAC 55.00 mg.

Phenethanol DAC 10.00 mg.

Glycerin DAB 7 30.00 mg.

Purified water EU.A.B. I, filled up to

1000.00 mg.

______________________________________

The Arlatone, Cetostearyl alcohol, stearic acid, paraffine, neutral oil and half of the Phenethanol are molten with heating to 60° C. in a container with a suitable stirrer of a high speed disperging machine. The active agent, glycerine and the remaining amount of Phenethanol are dissolved in the necessary amount of water and are also heated to 60° C. The aqueous phase is admixed homogenously into the fatty phase by means of the dispersing machine and the mixture is cooled to 30° C. with running stirrer.

›EXAMPLE 53

______________________________________

Eye ointment, 0.03% of urea base

______________________________________

1 g of the ointment contains:

N,N'-dimethyl-N-hexyl-N' 0.3 mg.

(2-morpholinoethyl)-urea

Benzyl alcohol 5.0 mg.

Eucerin, anhydricum 200.0 mg.

High viscosity paraffine 299.7 mg.

White vaseline 500.0 mg.

______________________________________

Eucerin, anhyricum, paraffine and vaseline are molten and mixed and sterilized for 3 hours at 140° C. Thereafter, the active agent and the benzyl alcohol are dissolved under aseptic conditions in the still liquid base and the mixture thereafter is cooled.

›EXAMPLE 54

______________________________________

Eye drops, 0.03% of urea base

______________________________________

1 cc. of the eye drops contains:

N,N'-dimethyl-N-hexyl-N' 0.34 mg.

(2-morpholinoethyl)-urea

Polyvinyl alcohol 10.00 mg.

Phenethanol DAC 5.00 mg.

Sodium chloride p.a. 7.10 mg.

Injection water, filled up to

1.00 cc.

______________________________________

The polyvinyl alcohol is dissolved with strong heating in water, the remaining components and the active agent are dissolved after cooling to about 30° C. The pH of the solution is brought to 7.4 by adding 0.1 N NaOH. After sterile filtration through a membrane filter the solution is filled into sterile eye drop containers under aseptic conditions.

2 of 14 part labels are ours — the grant heads the rest

Claims

5 · 3 independent · depth 2

5 granted claims

›1.independentBasically substituted ureas of the general Formula I ##STR24## wherein X is the group R.sub.4 --N<, p is 2 or 3, R.sub.1 is an alkyl group having from…+2

›2.independentN,N'-Dimethyl-N-n-tetradecyl-N'-[2-(1-diethylcarb amoyl-4-piperazinyl)-ethyl]-urea and its pharmaceutically acceptable acid addition salts.

›3.independentN,N'-Dimethyl -N-n-tetradecyl-N'-{2-[1-(2-p-toluyl-ethyl)-4-piperazinyl]-ethyl}-urea and its pharmaceutically acceptable acid addition salts.

Classifications

17 codes

IPC · International Patent Classification

Section A — Human necessities

A61P11/00
A61P1/00
A61K31/5375
A61K31/495
A61P25/00
A61P31/12
A61K31/535

Section C — Chemistry; metallurgy

C07D295/13
C07D295/20
C07D295/215
C07D295/26
C07D295/12
C07D295/22

USPC · US Patent Classification

424/250544/390544/399544/383

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›IP5 & PCT — 4 members

Office	Publication	Kind	Published	Filed	Status	Title
USthis patent	US-4239761-A	A	16 Dec 1980	23 Aug 1979	granted	Basically substituted ureas and processes for the treatment of virus diseases
EP	EP-0008696-A1	A1	19 Mar 1980	9 Aug 1979	published	Basisch substituierte Harnstoff-Verbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungende
EP	EP-0008696-B1	B1	15 Dec 1982	9 Aug 1979	granted	Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same
JP	JP-S5562078-A	A	10 May 1980	30 Aug 1979	published	Basic substituted urea compound

›Other offices — 18 members

Office	Publication	Kind	Published	Filed	Status	Title
AU	AU-4995279-A	A	6 Mar 1980	15 Aug 1979	published	Basically substituted urea derivatives
AU	AU-522184-B2	B2	20 May 1982	15 Aug 1979	granted	Basically substituted urea derivatives
CA	CA-1135695-A	A	16 Nov 1982	22 Aug 1979	granted	Procede d'obtention de composes ureiques a substitution basique et composes a proprietes pharmacologiques ainsi obtenusfr
DE	DE-2837794-A1	A1	13 Mar 1980	30 Aug 1978	published	Basisch substituierte harnstoffe und thioharnstoffe, verfahren zu ihrer herstellung und diese enthaltende arzneimittelde
DK	DK-361379-A	A	1 Mar 1980	29 Aug 1979	published	Basisk substituerede urinstoffer og fremgangsmaade til fremstilling derafda
ES	ES-483712-A0	A0	1 Dec 1980	29 Aug 1979	published	Procedimiento para la preparacion de nuevas ureas sustitui- das con radicales basicos.es
ES	ES-495003-A0	A0	16 Jun 1981	12 Sep 1980	published	Procedimiento para la preparacion de nuevas ureas sustitui- das con radicales basicoses
ES	ES-495008-A0	A0	16 Jun 1981	12 Sep 1980	published	Procedimiento para la preparacion de nuevas ureas sustitui- das con radicales basicoses
ES	ES-8105724-A1	A1	16 Jun 1981	12 Sep 1980	published	Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same.
ES	ES-8105725-A1	A1	16 Jun 1981	12 Sep 1980	published	Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same.
ES	ES-8101062-A1	A1	16 Apr 1982	29 Aug 1979	published	Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same.
FI	FI-792650-A7	A7	1 Jan 1981	24 Aug 1979	published	Emäksisesti substituoidut virtsa-aineet ja niiden valmistusmenetelmä.fi
GR	GR-66394-B	B	20 Mar 1981	13 Aug 1979	published	no title held
IE	IE-791648-L	L	29 Feb 1980	29 Aug 1979	published	Basically substituted urea compounds
IE	IE-48816-B1	B1	29 May 1985	29 Aug 1979	published	Basically substituted urea compounds,process for producing the same and pharmaceutical compositions containing the same
MC	MC-1276-A1	A1	23 May 1980	22 Aug 1979	published	Derives d'uree basiques substitues et procede pour leur preparationfr
NO	NO-792790-L	L	3 Mar 1980	28 Aug 1979	published	Basisk substituerte urinstoffer og fremgangsmaate for fremstilling derav.no
ZA	ZA-794173-B	B	27 Aug 1980	10 Aug 1979	published	Basically substituted urea compounds,process for producing the same and pharmaceutical compositions containing the same

Validity challenges

See the validity challenges on record — reexaminations, IPRs and PGRs, with their institution decisions and outcomes.

Citations

See every patent this one cites and every patent that cites it back — publication, assignee, and how each one was found.